| Year |
Citation |
Score |
| 2023 |
Nomura M, Murad NF, Madhavan SS, Eap B, Garcia TY, Aguirre CG, Verdin E, Ellerby L, Furman D, Newman JC. A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging. Biorxiv : the Preprint Server For Biology. PMID 38106160 DOI: 10.1101/2023.12.01.569598 |
0.747 |
|
| 2022 |
Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, ... ... Verdin E, et al. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell. e13724. PMID 36179270 DOI: 10.1111/acel.13724 |
0.565 |
|
| 2021 |
Chen O, Blonquist TM, Mah E, Sanoshy K, Beckman D, Nieman KM, Winters BL, Anthony JC, Verdin E, Newman JC, Stubbs BJ. Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults. Nutrients. 13. PMID 34208742 DOI: 10.3390/nu13062066 |
0.538 |
|
| 2021 |
Stubbs BJ, Nikiforov AI, Rihner MO, Weston SL, Higley N, Stump DG, Krane GA, Gadupudi G, Verdin E, Newman JC. Toxicological Evaluation of the ketogenic ester Bis Hexanoyl (R)-1,3-Butanediol: Subchronic Toxicity in Sprague Dawley Rats. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112084. PMID 33621607 DOI: 10.1016/j.fct.2021.112084 |
0.534 |
|
| 2021 |
Stubbs BJ, Nikiforov AI, Rihner MO, Weston S, Higley N, Roy S, Dakoulas E, Verdin E, Newman JC. Genetic Toxicity Studies of the Ketogenic Ester Bis Hexanoyl (R)-1,3-Butanediol. International Journal of Toxicology. 1091581821991772. PMID 33611970 DOI: 10.1177/1091581821991772 |
0.565 |
|
| 2020 |
Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD. Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure. Circulation. Heart Failure. CIRCHEARTFAILURE1200. PMID 33356362 DOI: 10.1161/CIRCHEARTFAILURE.120.007684 |
0.546 |
|
| 2020 |
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, ... ... Verdin E, et al. Author Correction: Senescent cells promote tissue NAD decline during ageing via the activation of CD38 macrophages. Nature Metabolism. PMID 33303985 DOI: 10.1038/s42255-020-00328-w |
0.584 |
|
| 2020 |
Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, ... ... Verdin E, et al. SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nature Communications. 11: 5927. PMID 33230181 DOI: 10.1038/s41467-020-19743-4 |
0.616 |
|
| 2020 |
Stubbs BJ, Blade T, Mills S, Thomas J, Yufei X, Nelson F, Higley N, Nikiforov AI, Rhiner MO, Verdin E, Newman JC. In Vitro Stability and In Vivo Pharmacokinetics of the Novel Ketogenic Ester, Bis Hexanoyl (R)-1,3-Butanediol. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 111859. PMID 33212214 DOI: 10.1016/j.fct.2020.111859 |
0.566 |
|
| 2020 |
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, ... ... Verdin E, et al. Senescent cells promote tissue NAD decline during ageing via the activation of CD38 macrophages. Nature Metabolism. 2: 1265-1283. PMID 33199924 DOI: 10.1038/s42255-020-00305-3 |
0.59 |
|
| 2020 |
Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (New York, N.Y.). PMID 32838361 DOI: 10.1016/j.medj.2020.06.008 |
0.576 |
|
| 2020 |
Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Sialyl-Lewis Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Cell Reports. 32: 107991. PMID 32755584 DOI: 10.1016/J.Celrep.2020.107991 |
0.354 |
|
| 2020 |
Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, ... Verdin E, et al. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nature Microbiology. PMID 32541947 DOI: 10.1038/S41564-020-0742-9 |
0.368 |
|
| 2020 |
Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells. Cell. PMID 32437658 DOI: 10.1016/J.Cell.2020.04.027 |
0.617 |
|
| 2019 |
Read DF, Atindaana E, Pyaram K, Yang F, Emery S, Cheong A, Nakama KR, Burnett C, Larragoite ET, Battivelli E, Verdin E, Planelles V, Chang CH, Telesnitsky A, Kidd JM. Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis. Plos Pathogens. 15: e1007903. PMID 31584995 DOI: 10.1371/Journal.Ppat.1007903 |
0.36 |
|
| 2019 |
Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 571: 183-192. PMID 31292558 DOI: 10.1038/S41586-019-1365-2 |
0.594 |
|
| 2019 |
Schilling B, Meyer JG, Wei L, Ott M, Verdin E. High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Methods in Molecular Biology (Clifton, N.J.). 1983: 3-16. PMID 31087289 DOI: 10.1007/978-1-4939-9434-2_1 |
0.315 |
|
| 2019 |
Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Molecular Cell. PMID 31000437 DOI: 10.1016/J.Molcel.2019.03.021 |
0.641 |
|
| 2019 |
Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, et al. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metabolism. PMID 30930169 DOI: 10.1016/J.Cmet.2019.03.001 |
0.332 |
|
| 2018 |
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. Plos One. 13: e0208973. PMID 30586434 DOI: 10.1371/Journal.Pone.0208973 |
0.474 |
|
| 2018 |
Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, et al. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells. Immunity. PMID 29802019 DOI: 10.1016/J.Immuni.2018.04.004 |
0.344 |
|
| 2018 |
Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Tojal Da Silva I, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4 T Cells. Elife. 7. PMID 29714165 DOI: 10.7554/Elife.34655 |
0.348 |
|
| 2018 |
Kasler HG, Lee IS, Lim HW, Verdin E. Histone deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T-Cells. Elife. 7. PMID 29664401 DOI: 10.7554/Elife.32109 |
0.36 |
|
| 2018 |
Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. NAD-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism. American Journal of Physiology. Endocrinology and Metabolism. PMID 29634313 DOI: 10.1152/Ajpendo.00057.2018 |
0.326 |
|
| 2018 |
Carrico C, Meyer JG, He W, Gibson BW, Verdin E. The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications. Cell Metabolism. 27: 497-512. PMID 29514063 DOI: 10.1016/J.Cmet.2018.01.016 |
0.385 |
|
| 2018 |
Ali I, Conrad RJ, Verdin E, Ott M. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chemical Reviews. PMID 29405707 DOI: 10.1021/Acs.Chemrev.7B00181 |
0.41 |
|
| 2018 |
Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378963 DOI: 10.1093/Geroni/Igy023.345 |
0.613 |
|
| 2018 |
Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Silva ITD, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. Author response: Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells Elife. DOI: 10.7554/Elife.34655.028 |
0.322 |
|
| 2018 |
Kasler HG, Lee IS, Lim HW, Verdin E. Author response: Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells Elife. DOI: 10.7554/Elife.32109.037 |
0.31 |
|
| 2018 |
Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Da Silva IT, Cohn LB, Gramatica A, Deeks S, Greene W, Pillai SK, Verdin E. D-106 Chromatin Functional States Correlate with the Reversal of Latently HIV-1 Infected Primary CD4+ T cells Jaids Journal of Acquired Immune Deficiency Syndromes. 77: 40. DOI: 10.1097/01.Qai.0000532598.61340.64 |
0.31 |
|
| 2017 |
Shrimp JH, Garlick J, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL. Defining metabolic and non-metabolic regulation of histone acetylation by a NSAID chemotype. Molecular Pharmaceutics. PMID 29240439 DOI: 10.1021/Acs.Molpharmaceut.7B00943 |
0.386 |
|
| 2017 |
Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 158: 2741-2753. PMID 28911171 DOI: 10.1210/En.2016-1739 |
0.632 |
|
| 2017 |
Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metabolism. 26: 547-557.e8. PMID 28877458 DOI: 10.1016/J.Cmet.2017.08.004 |
0.615 |
|
| 2017 |
Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metabolism. 26: 523-538.e5. PMID 28877456 DOI: 10.1016/J.Cmet.2017.08.015 |
0.628 |
|
| 2017 |
Newman JC, Verdin E. β-Hydroxybutyrate: A Signaling Metabolite. Annual Review of Nutrition. 37: 51-76. PMID 28826372 DOI: 10.1146/Annurev-Nutr-071816-064916 |
0.626 |
|
| 2016 |
Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, ... ... Verdin E, et al. The mTOR Complex Controls HIV Latency. Cell Host & Microbe. 20: 785-797. PMID 27978436 DOI: 10.1016/J.Chom.2016.11.001 |
0.332 |
|
| 2016 |
Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. Ebiomedicine. 8: 248-64. PMID 27428435 DOI: 10.1016/J.Ebiom.2016.04.039 |
0.32 |
|
| 2016 |
Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 5. PMID 27244239 DOI: 10.7554/Elife.11156 |
0.649 |
|
| 2015 |
Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science (New York, N.Y.). 350: 1208-13. PMID 26785480 DOI: 10.1126/Science.Aac4854 |
0.314 |
|
| 2015 |
Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metabolism. PMID 26686024 DOI: 10.1016/J.Cmet.2015.11.011 |
0.34 |
|
| 2015 |
Nishida Y, Rardin MJ, Carrico C, He W, Sahu AK, Gut P, Najjar R, Fitch M, Hellerstein M, Gibson BW, Verdin E. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Molecular Cell. PMID 26073543 DOI: 10.1016/J.Molcel.2015.05.022 |
0.393 |
|
| 2015 |
Chavez L, Calvanese V, Verdin E. HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. Plos Pathogens. 11: e1004955. PMID 26067822 DOI: 10.1371/Journal.Ppat.1004955 |
0.676 |
|
| 2015 |
Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, ... ... Verdin E, et al. SIRT1 deacetylates RORγt and enhances Th17 cell generation. The Journal of Experimental Medicine. 212: 607-17. PMID 25918343 DOI: 10.1084/Jem.20132378 |
0.341 |
|
| 2015 |
Ruelas DS, Chan JK, Oh E, Heidersbach AJ, Hebbeler AM, Chavez L, Verdin E, Rape M, Greene WC. MicroRNA-155 Reinforces HIV Latency. The Journal of Biological Chemistry. 290: 13736-48. PMID 25873391 DOI: 10.1074/Jbc.M115.641837 |
0.685 |
|
| 2015 |
Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. Plos One. 10: e0122297. PMID 25811481 DOI: 10.1371/Journal.Pone.0122297 |
0.311 |
|
| 2015 |
Dahabieh MS, Battivelli E, Verdin E. Understanding HIV latency: the road to an HIV cure. Annual Review of Medicine. 66: 407-21. PMID 25587657 DOI: 10.1146/Annurev-Med-092112-152941 |
0.315 |
|
| 2015 |
Verdin E, Ott M. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nature Reviews. Molecular Cell Biology. 16: 258-64. PMID 25549891 DOI: 10.1038/Nrm3931 |
0.388 |
|
| 2015 |
Chavez L, Calvanese V, Verdin E. HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells Plos Pathogens. 11. DOI: 10.1371/journal.ppat.1004955 |
0.637 |
|
| 2014 |
Newman JC, Verdin E. β-hydroxybutyrate: much more than a metabolite. Diabetes Research and Clinical Practice. 106: 173-81. PMID 25193333 DOI: 10.1016/J.Diabres.2014.08.009 |
0.65 |
|
| 2014 |
Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nature Reviews. Molecular Cell Biology. 15: 536-50. PMID 25053359 DOI: 10.1038/Nrm3841 |
0.396 |
|
| 2014 |
Colin L, Verdin E, Van Lint C. HIV-1 chromatin, transcription, and the regulatory protein Tat. Methods in Molecular Biology (Clifton, N.J.). 1087: 85-101. PMID 24158816 DOI: 10.1007/978-1-62703-670-2_8 |
0.395 |
|
| 2014 |
Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends in Endocrinology and Metabolism: Tem. 25: 42-52. PMID 24140022 DOI: 10.1016/J.Tem.2013.09.002 |
0.639 |
|
| 2013 |
Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, ... ... Verdin E, et al. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. Plos Pathogens. 9: e1003834. PMID 24385908 DOI: 10.1371/Journal.Ppat.1003834 |
0.333 |
|
| 2013 |
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, ... ... Verdin E, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metabolism. 18: 920-33. PMID 24315375 DOI: 10.1016/J.Cmet.2013.11.013 |
0.676 |
|
| 2013 |
Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging. 5: 835-49. PMID 24296486 |
0.655 |
|
| 2013 |
Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 502: 489-98. PMID 24153302 DOI: 10.1038/Nature12752 |
0.393 |
|
| 2013 |
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. The Journal of Biological Chemistry. 288: 33837-47. PMID 24121500 DOI: 10.1074/Jbc.M113.510354 |
0.361 |
|
| 2013 |
Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 446: 283-92. PMID 24074592 DOI: 10.1016/J.Virol.2013.07.037 |
0.672 |
|
| 2013 |
Verdin E, Ott M. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Molecular Cell. 51: 132-4. PMID 23870140 DOI: 10.1016/J.Molcel.2013.07.006 |
0.31 |
|
| 2013 |
Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 62: 3404-17. PMID 23835326 DOI: 10.2337/Db12-1650 |
0.413 |
|
| 2013 |
Ott M, Verdin E. Three rules for HIV latency: location, location, and location. Cell Host & Microbe. 13: 625-6. PMID 23768485 DOI: 10.1016/J.Chom.2013.05.016 |
0.325 |
|
| 2013 |
Gut P, Verdin E. Rejuvenating SIRT1 activators. Cell Metabolism. 17: 635-7. PMID 23663735 DOI: 10.1016/J.Cmet.2013.04.016 |
0.342 |
|
| 2013 |
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 6601-6. PMID 23576753 DOI: 10.1073/Pnas.1302961110 |
0.7 |
|
| 2013 |
Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. Reactivation of latent HIV by histone deacetylase inhibitors. Trends in Microbiology. 21: 277-85. PMID 23517573 DOI: 10.1016/J.Tim.2013.02.005 |
0.703 |
|
| 2013 |
Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 13: 705-20. PMID 23438705 DOI: 10.1016/J.Mito.2013.02.002 |
0.693 |
|
| 2013 |
Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 452-62. PMID 23255218 DOI: 10.4161/Cc.23309 |
0.378 |
|
| 2013 |
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, ... Verdin E, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.). 339: 211-4. PMID 23223453 DOI: 10.1126/Science.1227166 |
0.664 |
|
| 2013 |
Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chemical Biology. 9: 97-104. PMID 23201900 DOI: 10.1038/Nchembio.1136 |
0.323 |
|
| 2013 |
Calvanese V, Chavez L, Verdin E. C103 Identification, purification and characterization of latently-infected cells using novel fluorescent HIV viruses Jaids Journal of Acquired Immune Deficiency Syndromes. 62: S43. DOI: 10.1097/01.Qai.0000429222.46512.48 |
0.662 |
|
| 2012 |
Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. Acs Medicinal Chemistry Letters. 3: 1050-3. PMID 24900427 DOI: 10.1021/Ml3002709 |
0.379 |
|
| 2012 |
Kasler HG, Lim HW, Mottet D, Collins AM, Lee IS, Verdin E. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance. The Embo Journal. 31: 4453-65. PMID 23103766 DOI: 10.1038/Emboj.2012.295 |
0.332 |
|
| 2012 |
Newman JC, He W, Verdin E. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. The Journal of Biological Chemistry. 287: 42436-43. PMID 23086951 DOI: 10.1074/Jbc.R112.404863 |
0.675 |
|
| 2012 |
Bonezzi K, Belotti D, North BJ, Ghilardi C, Borsotti P, Resovi A, Ubezio P, Riva A, Giavazzi R, Verdin E, Taraboletti G. Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. Neoplasia (New York, N.Y.). 14: 846-54. PMID 23019416 DOI: 10.1593/Neo.12728 |
0.679 |
|
| 2012 |
Pan Y, Nishida Y, Wang M, Verdin E. Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology. 58: 524-30. PMID 22947849 DOI: 10.1159/000342204 |
0.336 |
|
| 2012 |
He W, Newman JC, Wang MZ, Ho L, Verdin E. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends in Endocrinology and Metabolism: Tem. 23: 467-76. PMID 22902903 DOI: 10.1016/J.Tem.2012.07.004 |
0.777 |
|
| 2012 |
Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 118: 5800-10. PMID 22674009 DOI: 10.1002/Cncr.27655 |
0.319 |
|
| 2012 |
Schilling B, Rardin MJ, MacLean BX, Zawadzka AM, Frewen BE, Cusack MP, Sorensen DJ, Bereman MS, Jing E, Wu CC, Verdin E, Kahn CR, Maccoss MJ, Gibson BW. Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Molecular & Cellular Proteomics : McP. 11: 202-14. PMID 22454539 DOI: 10.1074/Mcp.M112.017707 |
0.388 |
|
| 2012 |
Hakre S, Chavez L, Shirakawa K, Verdin E. HIV latency: experimental systems and molecular models. Fems Microbiology Reviews. 36: 706-16. PMID 22372374 DOI: 10.1111/J.1574-6976.2012.00335.X |
0.689 |
|
| 2012 |
Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 2712-21. PMID 22312127 DOI: 10.4049/Jimmunol.1100903 |
0.366 |
|
| 2012 |
Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. Journal of Proteome Research. 11: 1633-43. PMID 22309199 DOI: 10.1016/J.Freeradbiomed.2011.10.044 |
0.355 |
|
| 2012 |
Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, Boxus M, Verdin E, Thiry M, Dequiedt F, Mottet D. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells Cell Death and Differentiation. 19: 1239-1252. PMID 22301920 DOI: 10.1038/Cdd.2012.3 |
0.34 |
|
| 2012 |
Gallastegui E, Marshall B, Vidal D, Sanchez-Duffhues G, Collado JA, Alvarez-Fernández C, Luque N, Terme JM, Gatell JM, Sánchez-Palomino S, Muñoz E, Mestres J, Verdin E, Jordan A. Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1. Journal of Virology. 86: 3795-808. PMID 22258251 DOI: 10.1128/Jvi.05972-11 |
0.344 |
|
| 2012 |
Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. The Journal of Biological Chemistry. 287: 1090-9. PMID 22084242 DOI: 10.1074/Jbc.M111.282855 |
0.321 |
|
| 2012 |
Rafati H, Moshkin Y, Mahmoudi T, Parra M, Hakre S, Verdin E. New transcription regulatory mechanisms of latent HIV LTR Retrovirology. 9: O3. DOI: 10.1186/1742-4690-9-S1-O3 |
0.369 |
|
| 2011 |
Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. Plos Biology. 9: e1001206. PMID 22140357 DOI: 10.1371/Journal.Pbio.1001206 |
0.375 |
|
| 2011 |
Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 267-77. PMID 22114326 DOI: 10.1101/Sqb.2011.76.010850 |
0.639 |
|
| 2011 |
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, ... ... Verdin E, et al. The first identification of lysine malonylation substrates and its regulatory enzyme. Molecular & Cellular Proteomics : McP. 10: M111.012658. PMID 21908771 DOI: 10.1074/Mcp.M111.012658 |
0.686 |
|
| 2011 |
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proceedings of the National Academy of Sciences of the United States of America. 108: 14608-13. PMID 21873205 DOI: 10.1073/Pnas.1111308108 |
0.368 |
|
| 2011 |
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, StanÄáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Verdin E, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019 |
0.708 |
|
| 2011 |
Kasler HG, Young BD, Mottet D, Lim HW, Collins AM, Olson EN, Verdin E. Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 186: 4782-93. PMID 21398603 DOI: 10.4049/Jimmunol.1001179 |
0.372 |
|
| 2011 |
Hakre S, Chavez L, Shirakawa K, Verdin E. Epigenetic regulation of HIV latency. Current Opinion in Hiv and Aids. 6: 19-24. PMID 21242889 DOI: 10.1097/Coh.0B013E3283412384 |
0.681 |
|
| 2011 |
Chávez L, Kauder S, Verdin E. In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods (San Diego, Calif.). 53: 47-53. PMID 20670606 DOI: 10.1016/J.Ymeth.2010.05.009 |
0.677 |
|
| 2011 |
Kamarajan P, Alhazzazi T, D'Silva N, Verdin E, Kapila Y. Abstract 4768: Receptor interacting protein (RIP) and Sirtuin-3 (SIRT3) on opposite sides of anoikis resistance and promotes tumorigenesis Cancer Research. 71: 4768-4768. DOI: 10.1158/1538-7445.Am2011-4768 |
0.35 |
|
| 2010 |
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003 |
0.693 |
|
| 2010 |
Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends in Biochemical Sciences. 35: 669-75. PMID 20863707 DOI: 10.1016/J.Tibs.2010.07.003 |
0.354 |
|
| 2010 |
Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, ... ... Verdin E, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012 |
0.304 |
|
| 2010 |
Yan W, Si Y, Slaymaker S, Li J, Zheng H, Young DL, Aslanian A, Saunders L, Verdin E, Charo IF. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. The Journal of Biological Chemistry. 285: 31418-26. PMID 20675388 DOI: 10.1074/Jbc.M110.116418 |
0.336 |
|
| 2010 |
Trono D, Van Lint C, Rouzioux C, Verdin E, Barré-Sinoussi F, Chun TW, Chomont N. HIV persistence and the prospect of long-term drug-free remissions for hiv-infected individuals Science. 329: 174-180. PMID 20616270 DOI: 10.1126/Science.1191047 |
0.303 |
|
| 2010 |
Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. Acetate metabolism and aging: An emerging connection. Mechanisms of Ageing and Development. 131: 511-6. PMID 20478325 DOI: 10.1016/J.Mad.2010.05.001 |
0.692 |
|
| 2010 |
Parra M, Verdin E. Regulatory signal transduction pathways for class IIa histone deacetylases. Current Opinion in Pharmacology. 10: 454-60. PMID 20447866 DOI: 10.1016/J.Coph.2010.04.004 |
0.337 |
|
| 2010 |
Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host & Microbe. 7: 234-44. PMID 20227666 DOI: 10.1016/J.Chom.2010.02.005 |
0.355 |
|
| 2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... ... Verdin E, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.709 |
|
| 2010 |
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochimica Et Biophysica Acta. 1804: 1645-51. PMID 20060508 DOI: 10.1016/j.bbapap.2009.12.021 |
0.662 |
|
| 2010 |
Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O'Malley BW, Zhang M, Belaguli NS, Oesterreich S. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Molecular and Cellular Biology. 30: 399-412. PMID 19917725 DOI: 10.1128/Mcb.00907-09 |
0.359 |
|
| 2009 |
Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiguen A, Verdin E, Olive D, Van Lint C, Hejnar J, Hirsch I. CpG methylation controls reactivation of HIV from latency. Plos Pathogens. 5: e1000554. PMID 19696893 DOI: 10.1371/Journal.Ppat.1000554 |
0.346 |
|
| 2009 |
Kauder SE, Bosque A, Lindqvist A, Planelles V, Verdin E. Epigenetic regulation of HIV-1 latency by cytosine methylation. Plos Pathogens. 5: e1000495. PMID 19557157 DOI: 10.1371/Journal.Ppat.1000495 |
0.371 |
|
| 2009 |
Hirschey MD, Shimazu T, Huang JY, Verdin E. Acetylation of mitochondrial proteins. Methods in Enzymology. 457: 137-47. PMID 19426866 DOI: 10.1016/S0076-6879(09)05008-3 |
0.398 |
|
| 2009 |
Cooper HM, Huang JY, Verdin E, Spelbrink JN. A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. Plos One. 4: e4986. PMID 19333382 DOI: 10.1371/Journal.Pone.0004986 |
0.367 |
|
| 2009 |
Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1525-37. PMID 19193899 DOI: 10.1523/Jneurosci.5575-08.2009 |
0.763 |
|
| 2009 |
Schäfer S, Saunders L, Schlimme S, Valkov V, Wagner JM, Kratz F, Sippl W, Verdin E, Jung M. Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors Chemmedchem. 4: 283-290. PMID 19090524 DOI: 10.1002/Cmdc.200800196 |
0.31 |
|
| 2009 |
Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcène A, Verdin E, Castronovo V. HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene. 28: 243-56. PMID 18850004 DOI: 10.1038/Onc.2008.371 |
0.31 |
|
| 2008 |
Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, Sippl W. Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. Chemmedchem. 3: 1965-76. PMID 18985648 DOI: 10.1002/Cmdc.200800104 |
0.307 |
|
| 2008 |
Scott GK, Marx C, Berger CE, Saunders LR, Verdin E, Schäfer S, Jung M, Benz CC. Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Molecular Cancer Research : McR. 6: 1250-8. PMID 18644987 DOI: 10.1158/1541-7786.Mcr-07-2110 |
0.347 |
|
| 2008 |
Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, Verdin E, Sippl W, Jung M. Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. Journal of Medicinal Chemistry. 51: 1203-13. PMID 18269226 DOI: 10.1021/Jm700972E |
0.328 |
|
| 2008 |
Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metabolism. 7: 104-12. PMID 18249170 DOI: 10.1016/J.Cmet.2007.11.006 |
0.621 |
|
| 2008 |
Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorganic & Medicinal Chemistry. 16: 2011-33. PMID 18054239 DOI: 10.1016/J.Bmc.2007.10.092 |
0.321 |
|
| 2008 |
Bonezzi K, North B, Manzotti C, Riva A, Verdin E, Giavazzi R, Taraboletti G. 452 POSTER Tubulin acetylation and the antimotility effects of tubulin-targeting agents European Journal of Cancer Supplements. 6: 142. DOI: 10.1016/S1359-6349(08)72386-3 |
0.604 |
|
| 2007 |
Verdin E. AROuSing SIRT1: identification of a novel endogenous SIRT1 activator. Molecular Cell. 28: 354-6. PMID 17996699 DOI: 10.1016/J.Molcel.2007.10.013 |
0.337 |
|
| 2007 |
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, ... ... Verdin E, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07 |
0.684 |
|
| 2007 |
North BJ, Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. Plos One. 2: e784. PMID 17726514 DOI: 10.1371/Journal.Pone.0000784 |
0.691 |
|
| 2007 |
Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. The Journal of Biological Chemistry. 282: 33583-92. PMID 17715127 DOI: 10.1074/Jbc.M705488200 |
0.756 |
|
| 2007 |
Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 26: 5489-504. PMID 17694089 DOI: 10.1038/Sj.Onc.1210616 |
0.317 |
|
| 2007 |
Bisgrove DA, Mahmoudi T, Henklein P, Verdin E. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 13690-5. PMID 17690245 DOI: 10.1073/Pnas.0705053104 |
0.313 |
|
| 2007 |
North BJ, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. The Journal of Biological Chemistry. 282: 19546-55. PMID 17488717 DOI: 10.1074/Jbc.M702990200 |
0.677 |
|
| 2007 |
Kasler HG, Verdin E. Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes. Molecular and Cellular Biology. 27: 5184-200. PMID 17470548 DOI: 10.1128/Mcb.02091-06 |
0.339 |
|
| 2007 |
Barrett A, Santangelo S, Tan K, Catchpole S, Roberts K, Spencer-Dene B, Hall D, Scibetta A, Burchell J, Verdin E, Freemont P, Taylor-Papadimitriou J. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. International Journal of Cancer. Journal International Du Cancer. 121: 265-75. PMID 17373667 DOI: 10.1002/Ijc.22673 |
0.33 |
|
| 2007 |
Parra M, Mahmoudi T, Verdin E. Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes & Development. 21: 638-43. PMID 17369396 DOI: 10.1101/Gad.1513107 |
0.355 |
|
| 2007 |
Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S. Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Research. 67: 1019-29. PMID 17283134 DOI: 10.1158/0008-5472.Can-06-1638 |
0.336 |
|
| 2006 |
Trapp J, Jochum A, Meier R, Saunders L, Marshall B, Kunick C, Verdin E, Goekjian P, Sippl W, Jung M. Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. Journal of Medicinal Chemistry. 49: 7307-16. PMID 17149860 DOI: 10.1021/Jm060118B |
0.307 |
|
| 2006 |
Saunders LR, Verdin E. Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. Molecular Cancer Therapeutics. 5: 2777-85. PMID 17121924 DOI: 10.1158/1535-7163.Mct-06-0298 |
0.327 |
|
| 2006 |
Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proceedings of the National Academy of Sciences of the United States of America. 103: 10224-9. PMID 16788062 DOI: 10.1073/Pnas.0603968103 |
0.64 |
|
| 2006 |
Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. The Journal of Biological Chemistry. 281: 19960-8. PMID 16687403 DOI: 10.1074/Jbc.M603336200 |
0.378 |
|
| 2006 |
Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. The Embo Journal. 25: 139-49. PMID 16319923 DOI: 10.1038/Sj.Emboj.7600900 |
0.368 |
|
| 2005 |
Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, Smith MT. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases Plos Genetics. 1: e77. PMID 16362078 DOI: 10.1371/Journal.Pgen.0010077 |
0.333 |
|
| 2005 |
Bisgrove D, Lewinski M, Bushman F, Verdin E. Molecular mechanisms of HIV-1 proviral latency. Expert Review of Anti-Infective Therapy. 3: 805-14. PMID 16207172 DOI: 10.1586/14787210.3.5.805 |
0.352 |
|
| 2005 |
North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. Preparation of enzymatically active recombinant class III protein deacetylases. Methods (San Diego, Calif.). 36: 338-45. PMID 16091304 DOI: 10.1016/J.Ymeth.2005.03.004 |
0.763 |
|
| 2005 |
Wittich S, Scherf H, Xie C, Heltweg B, Dequiedt F, Verdin E, Gerhäuser C, Jung M. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines Anti-Cancer Drugs. 16: 635-643. PMID 15930892 DOI: 10.1097/00001813-200507000-00008 |
0.34 |
|
| 2005 |
Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, Verdin E, Berry CC, Ecker JR, Bushman FD. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. Journal of Virology. 79: 6610-9. PMID 15890899 DOI: 10.1128/Jvi.79.11.6610-6619.2005 |
0.372 |
|
| 2005 |
Jayakumar P, Berger I, Autschbach F, Weinstein M, Funke B, Verdin E, Goldsmith MA, Keppler OT. Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. Journal of Virology. 79: 5220-6. PMID 15795306 DOI: 10.1128/Jvi.79.8.5220-5226.2005 |
0.569 |
|
| 2005 |
Waltregny D, Glénisson W, Tran SL, North BJ, Verdin E, Colige A, Castronovo V. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 966-8. PMID 15772115 DOI: 10.1096/Fj.04-2303Fje |
0.668 |
|
| 2005 |
Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. SIRT1 regulates HIV transcription via Tat deacetylation. Plos Biology. 3: e41. PMID 15719057 DOI: 10.1371/Journal.Pbio.0030041 |
0.71 |
|
| 2005 |
Parra M, Kasler H, McKinsey TA, Olson EN, Verdin E. Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation Journal of Biological Chemistry. 280: 13762-13770. PMID 15623513 DOI: 10.1074/Jbc.M413396200 |
0.362 |
|
| 2004 |
Waltregny D, North B, Van Mellaert F, De Leval J, Verdin E, Castronovo V. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells European Journal of Histochemistry. 48: 273-290. PMID 15590418 DOI: 10.4081/897 |
0.677 |
|
| 2004 |
Heltweg B, Dequiedt F, Marshall BL, Brauch C, Yoshida M, Nishino N, Verdin E, Jung M. Subtype selective substrates for histone deacetylases Journal of Medicinal Chemistry. 47: 5235-5243. PMID 15456267 DOI: 10.1021/Jm0497592 |
0.311 |
|
| 2004 |
Williams SA, Chen LF, Kwon H, Fenard D, Bisgrove D, Verdin E, Greene WC. Prostratin antagonizes HIV latency by activating NF-kappaB. The Journal of Biological Chemistry. 279: 42008-17. PMID 15284245 DOI: 10.1074/Jbc.M402124200 |
0.38 |
|
| 2004 |
Waltregny D, De Leval L, Glénisson W, Ly Tran S, North BJ, Bellahcène A, Weidle U, Verdin E, Castronovo V. Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. The American Journal of Pathology. 165: 553-64. PMID 15277229 DOI: 10.1016/S0002-9440(10)63320-2 |
0.688 |
|
| 2004 |
Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Foundation Symposium. 259: 182-93; discussion 1. PMID 15171254 DOI: 10.1002/0470862637.Ch13 |
0.34 |
|
| 2004 |
Verdin E, Dequiedt F, Kasler H, Olson, Mabadevan, Marks, Berger. HDAC7 regulates apoptosis in developing thymocytes Novartis Foundation Symposium. 259: 115-131. PMID 15171250 DOI: 10.1002/0470862637.Ch8 |
0.318 |
|
| 2004 |
North BJ, Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biology. 5: 224. PMID 15128440 DOI: 10.1186/Gb-2004-5-5-224 |
0.691 |
|
| 2004 |
Verdin E, Dequiedt F, Fischle W, Frye R, Marshall B, North B. Measurement of Mammalian Histone Deacetylase Activity Methods in Enzymology. 377: 180-196. PMID 14979025 DOI: 10.1016/S0076-6879(03)77010-4 |
0.673 |
|
| 2003 |
Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Molecular Cell. 12: 167-76. PMID 12887902 DOI: 10.1016/S1097-2765(03)00245-4 |
0.322 |
|
| 2003 |
Heltweg B, Dequiedt F, Verdin E, Jung M. Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases Analytical Biochemistry. 319: 42-48. PMID 12842105 DOI: 10.1016/S0003-2697(03)00276-8 |
0.326 |
|
| 2003 |
Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, Verdin E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 18: 687-98. PMID 12753745 DOI: 10.1016/S1074-7613(03)00109-2 |
0.364 |
|
| 2003 |
Verdin E, Dequiedt F, Kasler HG. Class II histone deacetylases: versatile regulators. Trends in Genetics : Tig. 19: 286-93. PMID 12711221 DOI: 10.1016/S0168-9525(03)00073-8 |
0.354 |
|
| 2003 |
Jordan A, Bisgrove D, Verdin E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro Embo Journal. 22: 1868-1877. PMID 12682019 DOI: 10.1093/Emboj/Cdg188 |
0.332 |
|
| 2003 |
Pion M, Jordan A, Biancotto A, Dequiedt F, Gondois-Rey F, Rondeau S, Vigne R, Hejnar J, Verdin E, Hirsch I. Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. Journal of Virology. 77: 4025-32. PMID 12634362 DOI: 10.1128/Jvi.77.7.4025-4032.2003 |
0.353 |
|
| 2003 |
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Molecular Cell. 11: 437-44. PMID 12620231 DOI: 10.1016/S1097-2765(03)00038-8 |
0.697 |
|
| 2002 |
Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. The Journal of Cell Biology. 158: 647-57. PMID 12186850 DOI: 10.1083/Jcb.200205057 |
0.77 |
|
| 2002 |
Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. The Embo Journal. 21: 2715-23. PMID 12032084 DOI: 10.1093/Emboj/21.11.2715 |
0.39 |
|
| 2002 |
Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Molecular Cell. 9: 575-86. PMID 11931765 DOI: 10.1016/S1097-2765(02)00483-5 |
0.377 |
|
| 2002 |
Murphy JC, Fischle W, Verdin E, Sinclair JH. Control of cytomegalovirus lytic gene expression by histone acetylation Embo Journal. 21: 1112-1120. PMID 11867539 DOI: 10.1093/Emboj/21.5.1112 |
0.399 |
|
| 2002 |
Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR, Denu JM. Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. The Journal of Biological Chemistry. 277: 12632-41. PMID 11812793 DOI: 10.1074/Jbc.M111830200 |
0.346 |
|
| 2002 |
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molecular Cell. 9: 45-57. PMID 11804585 DOI: 10.1016/S1097-2765(01)00429-4 |
0.344 |
|
| 2001 |
Chen LF, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-κB action regulated by reversible acetylation Science. 293: 1653-1657. PMID 11533489 DOI: 10.1126/Science.1062374 |
0.323 |
|
| 2001 |
Kruhlak MJ, Hendzel MJ, Fischle W, Bertos NR, Hameed S, Yang XJ, Verdin E, Bazett-Jones DP. Regulation of Global Acetylation in Mitosis through Loss of Histone Acetyltransferases and Deacetylases from Chromatin Journal of Biological Chemistry. 276: 38307-38319. PMID 11479283 DOI: 10.1074/Jbc.M100290200 |
0.356 |
|
| 2001 |
Fischle W, Kiermer V, Dequiedt F, Verdin E. The emerging role of class II histone deacetylases Biochemistry and Cell Biology. 79: 337-348. PMID 11467747 DOI: 10.1139/O01-116 |
0.341 |
|
| 2001 |
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E. Human HDAC7 Histone Deacetylase Activity is Associated with HDAC3 in Vivo Journal of Biological Chemistry. 276: 35826-35835. PMID 11466315 DOI: 10.1074/Jbc.M104935200 |
0.343 |
|
| 2001 |
Jordan A, Defechereux P, Verdin E. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation Embo Journal. 20: 1726-1738. PMID 11285236 DOI: 10.1093/Emboj/20.7.1726 |
0.387 |
|
| 2000 |
Wang JK, Kiyokawa E, Verdin E, Trono D. The Nef protein of HIV-1 associates with rafts and primes T cells for activation Proceedings of the National Academy of Sciences of the United States of America. 97: 394-399. PMID 10618429 DOI: 10.1073/Pnas.97.1.394 |
0.332 |
|
| 2000 |
Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-1057. DOI: 10.1101/Gad.14.9.1048 |
0.345 |
|
| 2000 |
Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression Genes & Development. 14: 1810-1823. DOI: 10.1101/Gad.14.14.1810 |
0.309 |
|
| 1999 |
Ott M, Schnölzer M, Garnica J, Fischle W, Emiliani S, Rackwitz HR, Verdin E. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Current Biology : Cb. 9: 1489-92. PMID 10607594 DOI: 10.1016/S0960-9822(00)80120-7 |
0.389 |
|
| 1999 |
Mahlknecht U, Bucala R, Hoelzer D, Verdin E. High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region Cytogenetic and Genome Research. 86: 237-239. PMID 10575214 DOI: 10.1159/000015347 |
0.31 |
|
| 1999 |
Critchfield JW, Ho O, Roberts BD, Van Lint C, Verdin E, Butera ST. Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency. Antiviral Chemistry & Chemotherapy. 10: 275-84. PMID 10574182 DOI: 10.1177/095632029901000506 |
0.369 |
|
| 1999 |
Mahlknecht U, Hoelzer D, Bucala R, Verdin E. Cloning and characterization of the murine histone deacetylase (HDAC3). Biochemical and Biophysical Research Communications. 263: 482-490. PMID 10491319 DOI: 10.1006/Bbrc.1999.1389 |
0.351 |
|
| 1999 |
Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. The Journal of Biological Chemistry. 274: 11713-20. PMID 10206986 DOI: 10.1074/Jbc.274.17.11713 |
0.343 |
|
| 1999 |
Mahlknecht U, Emiliani S, Najfeld V, Young S, Verdin E. Genomic Organization and Chromosomal Localization of the Human Histone Deacetylase 3 Gene Genomics. 56: 197-202. PMID 10051405 DOI: 10.1006/Geno.1998.5645 |
0.34 |
|
| 1999 |
Kruhlak MJ, Hendzel MJ, Fischle W, Verdin E, Bazett-Jones DP. Reduction of histone acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin Biochemistry and Cell Biology. 77: 400. DOI: 10.1139/O99-903T |
0.304 |
|
| 1998 |
Herbein G, Mahlknecht U, Batliwalla F, Gregersen P, Pappas T, Butler J, O'Brien WA, Verdin E. Apoptosis of CD8 + T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 Nature. 395: 189-194. PMID 9744279 DOI: 10.1038/26026 |
0.331 |
|
| 1998 |
Kiermer V, Lint CV, Briclet D, Vanhulle C, Kettmann R, Verdin E, Burny A, Droogmans L. An Interferon Regulatory Factor Binding Site in the U5 Region of the Bovine Leukemia Virus Long Terminal Repeat Stimulates Tax-Independent Gene Expression Journal of Virology. 72: 5526-5534. PMID 9621009 DOI: 10.1128/Jvi.72.7.5526-5534.1998 |
0.302 |
|
| 1998 |
Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, Marks PA. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America. 95: 3003-7. PMID 9501205 DOI: 10.1073/Pnas.95.6.3003 |
0.326 |
|
| 1998 |
Emiliani S, Fischle W, Lint CV, Al-Abed Y, Verdin E. Characterization of a human RPD3 ortholog, HDAC3 Proceedings of the National Academy of Sciences of the United States of America. 95: 2795-2800. PMID 9501169 DOI: 10.1073/Pnas.95.6.2795 |
0.373 |
|
| 1998 |
Emiliani S, Fischle W, Ott M, Van Lint C, Amella CA, Verdin E. Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line. Journal of Virology. 72: 1666-70. PMID 9445075 DOI: 10.1128/Jvi.72.2.1666-1670.1998 |
0.342 |
|
| 1998 |
Herbein G, Lint CV, Lovett JL, Verdin E. Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes Journal of Virology. 72: 660-670. PMID 9420271 DOI: 10.1128/Jvi.72.1.660-670.1998 |
0.318 |
|
| 1997 |
Sheridan PL, Mayall TP, Verdin E, Jones KA. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes & Development. 11: 3327-40. PMID 9407026 DOI: 10.1101/Gad.11.24.3327 |
0.404 |
|
| 1997 |
Lint CV, Amella CA, Emiliani S, John M, Jie T, Verdin E. Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity. Journal of Virology. 71: 6113-6127. PMID 9223506 DOI: 10.1128/Jvi.71.8.6113-6127.1997 |
0.301 |
|
| 1997 |
Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science (New York, N.Y.). 275: 1481-5. PMID 9045614 DOI: 10.1126/Science.275.5305.1481 |
0.308 |
|
| 1996 |
Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E. A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency. Proceedings of the National Academy of Sciences of the United States of America. 93: 6377-81. PMID 8692823 DOI: 10.1073/Pnas.93.13.6377 |
0.313 |
|
| 1996 |
Van Lint C, Emiliani S, Ott M, Verdin E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. The Embo Journal. 15: 1112-1120. DOI: 10.1002/J.1460-2075.1996.Tb00449.X |
0.389 |
|
| 1995 |
Verdin E, Van Lint C, Ott M, Emiliani S. Role of chromatin in the transcriptional regulation of HIV-1 Journal of Cancer Research and Clinical Oncology. 121: S36-S36. DOI: 10.1007/Bf02559898 |
0.367 |
|
| 1994 |
Lint CV, Ghysdael J, Paras P, Burny A, Verdin E. A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1. Journal of Virology. 68: 2632-2648. PMID 8139041 DOI: 10.1128/Jvi.68.4.2632-2648.1994 |
0.334 |
|
| 1993 |
Verdin E, Paras P, Lint CV. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation The Embo Journal. 12: 3249-3259. DOI: 10.1002/J.1460-2075.1993.Tb05994.X |
0.381 |
|
| 1992 |
Sharpless NE, O'Brien WA, Verdin E, Kufta CV, Chen ISY, Dubois-Dalcq M. Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism Journal of Virology. 66: 2588-2593. PMID 1548785 DOI: 10.1128/Jvi.66.4.2588-2593.1992 |
0.32 |
|
| 1992 |
Sharpless N, Gilbert D, Vandercam B, Zhou JM, Verdin E, Ronnett G, Friedman E, Dubois-Dalcq M. The restricted nature of HIV-1 tropism for cultured neural cells Virology. 191: 813-825. PMID 1448925 DOI: 10.1016/0042-6822(92)90257-P |
0.321 |
|
| 1991 |
Lint CV, Burny A, Verdin E. The intragenic enhancer of human immunodeficiency virus type 1 contains functional AP-1 binding sites Journal of Virology. 65: 7066-7072. PMID 1942259 DOI: 10.1128/Jvi.65.12.7066-7072.1991 |
0.321 |
|
| 1991 |
Verdin E. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1. Journal of Virology. 65: 6790-6799. DOI: 10.1128/Jvi.65.12.6790-6799.1991 |
0.354 |
|
| 1990 |
Verdin E, Becker N, Bex F, Droogmans L, Burny A. Identification and characterization of an enhancer in the coding region of the genome of human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America. 87: 4874-8. PMID 2352955 DOI: 10.1073/Pnas.87.12.4874 |
0.369 |
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