| Year |
Citation |
Score |
| 2018 |
Liang L, Wang H, Shi H, Li Z, Yao H, Bu Z, Song N, Li C, Xiang D, Zhang Y, Wang J, Hu Y, Xu Q, Ma Y, Cheng Z, et al. A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. Cell Chemical Biology. PMID 29681526 DOI: 10.1016/J.Chembiol.2018.03.010 |
0.306 |
|
| 2016 |
Hu Y, Stumpfe D, Bajorath J. Recent Advances in Scaffold Hopping. Journal of Medicinal Chemistry. PMID 28001064 DOI: 10.1021/Acs.Jmedchem.6B01437 |
0.327 |
|
| 2016 |
Hu Y, Stumpfe D, Bajorath J. Computational Exploration of Molecular Scaffolds in Medicinal Chemistry. Journal of Medicinal Chemistry. PMID 26840095 DOI: 10.1021/Acs.Jmedchem.5B01746 |
0.326 |
|
| 2016 |
Jasial S, Hu Y, Bajorath J. Assessing the Growth of Bioactive Compounds and Scaffolds over Time: Implications for Lead Discovery and Scaffold Hopping. Journal of Chemical Information and Modeling. PMID 26838127 DOI: 10.1021/Acs.Jcim.5B00713 |
0.339 |
|
| 2015 |
Hu Y, Zhang B, Bajorath J. Method for Systematic Assessment of Chemical Changes in Molecular Scaffolds with Conserved Topology and Application to the Analysis of Scaffold-Activity Relationships. Molecular Informatics. 34: 531-549. PMID 27490499 DOI: 10.1002/Minf.201500034 |
0.321 |
|
| 2015 |
Furtmann N, Hu Y, Gütschow M, Bajorath J. Identification of Interaction Hotspots in Structures of Drug Targets on the Basis of Three-Dimensional Activity Cliff Information. Chemical Biology & Drug Design. PMID 26094578 DOI: 10.1111/Cbdd.12605 |
0.321 |
|
| 2015 |
Hu Y, Jasial S, Bajorath J. Promiscuity progression of bioactive compounds over time. F1000research. 4: 118. PMID 26064479 DOI: 10.12688/F1000Research.6473.1 |
0.324 |
|
| 2015 |
Hu Y, Bajorath J. Exploring the scaffold universe of kinase inhibitors. Journal of Medicinal Chemistry. 58: 315-32. PMID 25192260 DOI: 10.1021/Jm501237K |
0.308 |
|
| 2015 |
Fan J, Meng QH, Bone C, Igo S, Hu Y. Abstract 598: Circulating peptides for predicting subsequent cardiotoxicity in cancer patients with chemotherapies Cancer Research. 75: 598-598. DOI: 10.1158/1538-7445.Am2015-598 |
0.3 |
|
| 2015 |
Hu Y, Furtmann N, Bajorath J. Extension of three-dimensional activity cliff information through systematic mapping of active analogs Rsc Advances. 5: 43006-43015. DOI: 10.1039/C5Ra01732G |
0.317 |
|
| 2014 |
de la Vega de León A, Hu Y, Bajorath J. Systematic Identification of Matching Molecular Series and Mapping of Screening Hits. Molecular Informatics. 33: 257-63. PMID 27485771 DOI: 10.1002/Minf.201400017 |
0.304 |
|
| 2014 |
Huang H, Zhao P, Chen PY, Ren Y, Liu X, Ferrari M, Hu Y, Akinwande D. RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring. Ieee Journal of Translational Engineering in Health and Medicine. 2: 1700108. PMID 27170865 DOI: 10.1109/Jtehm.2014.2309335 |
0.387 |
|
| 2014 |
Hu Y, Bajorath J. Influence of search parameters and criteria on compound selection, promiscuity, and pan assay interference characteristics. Journal of Chemical Information and Modeling. 54: 3056-66. PMID 25329977 DOI: 10.1021/Ci5005509 |
0.303 |
|
| 2014 |
Hu Y, Gupta-Ostermann D, Bajorath J. Exploring compound promiscuity patterns and multi-target activity spaces. Computational and Structural Biotechnology Journal. 9: e201401003. PMID 24688751 DOI: 10.5936/Csbj.201401003 |
0.333 |
|
| 2014 |
Fan J, Niu S, Dong A, Shi J, Wu HJ, Fine DH, Tian Y, Zhou C, Liu X, Sun T, Anderson GJ, Ferrari M, Nie G, Hu Y, Zhao Y. Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 879-88. PMID 24566273 DOI: 10.1016/J.Nano.2014.02.005 |
0.437 |
|
| 2014 |
Wu HJ, Li Y, Fan J, Deng Z, Hu Z, Liu X, Graviss EA, Ferrari M, Ma X, Hu Y. Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps. Analytical Chemistry. 86: 1988-96. PMID 24446580 DOI: 10.1021/Ac4027669 |
0.425 |
|
| 2014 |
Li Y, Li Y, Chen T, Kuklina AS, Bernard P, Esteva FJ, Shen H, Ferrari M, Hu Y. Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer. Clinical Chemistry. 60: 233-42. PMID 24146311 DOI: 10.1373/Clinchem.2013.211953 |
0.432 |
|
| 2014 |
Stumpfe D, Hu Y, Dimova D, Bajorath J. Recent progress in understanding activity cliffs and their utility in medicinal chemistry. Journal of Medicinal Chemistry. 57: 18-28. PMID 23981118 DOI: 10.1021/Jm401120G |
0.304 |
|
| 2013 |
Gupta-Ostermann D, Hu Y, Bajorath J. Systematic mining of analog series with related core structures in multi-target activity space. Journal of Computer-Aided Molecular Design. 27: 665-74. PMID 23975272 DOI: 10.1007/S10822-013-9671-5 |
0.332 |
|
| 2013 |
Namasivayam V, Hu Y, Balfer J, Bajorath J. Classification of compounds with distinct or overlapping multi-target activities and diverse molecular mechanisms using emerging chemical patterns. Journal of Chemical Information and Modeling. 53: 1272-81. PMID 23692475 DOI: 10.1021/Ci400186N |
0.326 |
|
| 2013 |
Fine D, Grattoni A, Goodall R, Bansal SS, Chiappini C, Hosali S, van de Ven AL, Srinivasan S, Liu X, Godin B, Brousseau L, Yazdi IK, Fernandez-Moure J, Tasciotti E, Wu HJ, ... Hu Y, et al. Silicon micro- and nanofabrication for medicine. Advanced Healthcare Materials. 2: 632-66. PMID 23584841 DOI: 10.1002/Adhm.201200214 |
0.35 |
|
| 2013 |
Hu Y, Bajorath J. Compound promiscuity: what can we learn from current data? Drug Discovery Today. 18: 644-50. PMID 23524195 DOI: 10.1016/J.Drudis.2013.03.002 |
0.337 |
|
| 2013 |
Hu Y, Bajorath J. Introduction of target cliffs as a concept to identify and describe complex molecular selectivity patterns. Journal of Chemical Information and Modeling. 53: 545-52. PMID 23379346 DOI: 10.1021/Ci300602M |
0.321 |
|
| 2013 |
Hu Y, Bajorath J. Systematic identification of scaffolds representing compounds active against individual targets and single or multiple target families. Journal of Chemical Information and Modeling. 53: 312-26. PMID 23339619 DOI: 10.1021/Ci300616S |
0.312 |
|
| 2013 |
Hu Y, Maggiora GM, Bajorath J. Activity cliffs in PubChem confirmatory bioassays taking inactive compounds into account. Journal of Computer-Aided Molecular Design. 27: 115-24. PMID 23296990 DOI: 10.1007/S10822-012-9632-4 |
0.317 |
|
| 2013 |
Fan J, Huang Y, Finoulst I, Wu HJ, Deng Z, Xu R, Xia X, Ferrari M, Shen H, Hu Y. Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer Letters. 334: 202-10. PMID 23200677 DOI: 10.1016/J.Canlet.2012.11.011 |
0.451 |
|
| 2013 |
Hu Y, Bajorath J. How promiscuous are pharmaceutically relevant compounds? A data-driven assessment. The Aaps Journal. 15: 104-11. PMID 23090085 DOI: 10.1208/S12248-012-9421-Y |
0.329 |
|
| 2013 |
Fine D, Grattoni A, Goodall R, Bansal SS, Chiappini C, Hosali S, van de Ven AL, Srinivasan S, Liu X, Godin B, Brousseau L, Yazdi IK, Fernandez-Moure J, Tasciotti E, Wu H, ... Hu Y, et al. Biocomposites: Silicon Micro- and Nanofabrication for Medicine (Adv. Healthcare Mater. 5/2013) Advanced Healthcare Materials. 2: 625-625. DOI: 10.1002/Adhm.201370024 |
0.375 |
|
| 2012 |
Grattoni A, Tasciotti E, Fine D, Fernandez-Moure JS, Sakamoto J, Hu Y, Weiner B, Ferrari M, Parazynski S. Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. Aviation, Space, and Environmental Medicine. 83: 1025-36. PMID 23156089 DOI: 10.3357/Asem.3307.2012 |
0.342 |
|
| 2012 |
Dimova D, Hu Y, Bajorath J. Matched molecular pair analysis of small molecule microarray data identifies promiscuity cliffs and reveals molecular origins of extreme compound promiscuity. Journal of Medicinal Chemistry. 55: 10220-8. PMID 23050678 DOI: 10.1021/Jm301292A |
0.338 |
|
| 2012 |
Hu Y, Bajorath J. Growth of ligand-target interaction data in ChEMBL is associated with increasing and activity measurement-dependent compound promiscuity. Journal of Chemical Information and Modeling. 52: 2550-8. PMID 22978710 DOI: 10.1021/Ci3003304 |
0.32 |
|
| 2012 |
Hu Y, Bajorath J. Extending the activity cliff concept: structural categorization of activity cliffs and systematic identification of different types of cliffs in the ChEMBL database. Journal of Chemical Information and Modeling. 52: 1806-11. PMID 22758389 DOI: 10.1021/Ci300274C |
0.305 |
|
| 2012 |
Fan J, Gallagher JW, Wu HJ, Landry MG, Sakamoto J, Ferrari M, Hu Y. Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery. Journal of Visualized Experiments : Jove. PMID 22546927 DOI: 10.3791/3876 |
0.481 |
|
| 2012 |
Fan J, Deng X, Gallagher JW, Huang H, Huang Y, Wen J, Ferrari M, Shen H, Hu Y. Monitoring the progression of metastatic breast cancer on nanoporous silica chips. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 370: 2433-47. PMID 22509065 DOI: 10.1098/Rsta.2011.0444 |
0.445 |
|
| 2012 |
Hu X, Hu Y, Vogt M, Stumpfe D, Bajorath J. MMP-Cliffs: systematic identification of activity cliffs on the basis of matched molecular pairs. Journal of Chemical Information and Modeling. 52: 1138-45. PMID 22489665 DOI: 10.1021/Ci3001138 |
0.303 |
|
| 2012 |
Hu Y, Bajorath J. Exploration of 3D activity cliffs on the basis of compound binding modes and comparison of 2D and 3D cliffs. Journal of Chemical Information and Modeling. 52: 670-7. PMID 22394306 DOI: 10.1021/Ci300033E |
0.307 |
|
| 2012 |
Hu Y, Ferrari M. Abstract LB-413: Nanopore-based assay for discovery and enrichment of tumor progression biomarkers from human serum Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-413 |
0.412 |
|
| 2012 |
Fan J, Hu Y, Shen H, Deng X. Abstract 437: Exploring biomarkers of metastatic breast cancer based on nanoporous silica chip for early diagnosis and therapeutic evaluation Cancer Research. 72: 437-437. DOI: 10.1158/1538-7445.Am2012-437 |
0.303 |
|
| 2011 |
Hu Y, Bajorath J. Chemical transformations that yield compounds with distinct activity profiles. Acs Medicinal Chemistry Letters. 2: 523-7. PMID 24900343 DOI: 10.1021/Ml2000609 |
0.309 |
|
| 2011 |
Zhou M, Hu Y, Ferrari M, Xie Z. Self-assembled zinc/copper hydroxide carbonates with tunable hierarchical nanostructure. Journal of Nanoscience and Nanotechnology. 11: 7037-41. PMID 22103119 DOI: 10.1166/Jnn.2011.4234 |
0.394 |
|
| 2011 |
Hu Y, Bajorath J. Target family-directed exploration of scaffolds with different SAR profiles. Journal of Chemical Information and Modeling. 51: 3138-48. PMID 22091691 DOI: 10.1021/Ci200461W |
0.323 |
|
| 2011 |
Sharma T, Hu Y, Stoller M, Feldman M, Ruoff RS, Ferrari M, Zhang X. Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cells. Lab On a Chip. 11: 2460-5. PMID 21637881 DOI: 10.1039/C1Lc20119K |
0.307 |
|
| 2011 |
Hu Y, Gopal A, Lin K, Peng Y, Tasciotti E, Zhang XJ, Ferrari M. Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip. Biomicrofluidics. 5: 13410. PMID 21522500 DOI: 10.1063/1.3528237 |
0.374 |
|
| 2011 |
Iyer P, Hu Y, Bajorath J. SAR monitoring of evolving compound data sets using activity landscapes. Journal of Chemical Information and Modeling. 51: 532-40. PMID 21322535 DOI: 10.1021/Ci100505M |
0.323 |
|
| 2011 |
Hu Y, Peng Y, Lin K, Shen H, Brousseau LC, Sakamoto J, Sun T, Ferrari M. Surface engineering on mesoporous silica chips for enriching low molecular weight phosphorylated proteins. Nanoscale. 3: 421-8. PMID 21135976 DOI: 10.1039/C0Nr00720J |
0.387 |
|
| 2011 |
Fan J, Yin JJ, Ning B, Wu X, Hu Y, Ferrari M, Anderson GJ, Wei J, Zhao Y, Nie G. Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles. Biomaterials. 32: 1611-8. PMID 21112084 DOI: 10.1016/J.Biomaterials.2010.11.004 |
0.397 |
|
| 2011 |
Hu Y, Fine DH, Tasciotti E, Bouamrani A, Ferrari M. Nanodevices in diagnostics. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 3: 11-32. PMID 20229595 DOI: 10.1002/Wnan.82 |
0.439 |
|
| 2010 |
Hu Y, Bajorath J. Exploring target-selectivity patterns of molecular scaffolds. Acs Medicinal Chemistry Letters. 1: 54-8. PMID 24900176 DOI: 10.1021/Ml900024V |
0.331 |
|
| 2010 |
Hu Y, Peng Y, Brousseau L, Bouamrani A, Liu X, Ferrari M. Nanotexture Optimization by Oxygen Plasma of Mesoporous Silica Thin Film for Enrichment of Low Molecular Weight Peptides Captured from Human Serum. Science China. Chemistry. 53: 2257-2264. PMID 21179395 DOI: 10.1007/S11426-010-4121-X |
0.436 |
|
| 2010 |
Hu Y, Bajorath J. Polypharmacology directed compound data mining: identification of promiscuous chemotypes with different activity profiles and comparison to approved drugs. Journal of Chemical Information and Modeling. 50: 2112-8. PMID 21070069 DOI: 10.1021/Ci1003637 |
0.347 |
|
| 2010 |
Blinka E, Loeffler K, Hu Y, Gopal A, Hoshino K, Lin K, Liu X, Ferrari M, Zhang JX. Enhanced microcontact printing of proteins on nanoporous silica surface. Nanotechnology. 21: 415302. PMID 20834118 DOI: 10.1088/0957-4484/21/41/415302 |
0.341 |
|
| 2010 |
Hu Y, Bajorath J. Molecular scaffolds with high propensity to form multi-target activity cliffs. Journal of Chemical Information and Modeling. 50: 500-10. PMID 20361784 DOI: 10.1021/Ci100059Q |
0.348 |
|
| 2010 |
Hu Y, Bouamrani A, Tasciotti E, Li L, Liu X, Ferrari M. Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein. Acs Nano. 4: 439-51. PMID 20014864 DOI: 10.1021/Nn901322D |
0.451 |
|
| 2010 |
Bouamrani A, Hu Y, Tasciotti E, Li L, Chiappini C, Liu X, Ferrari M. Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome. Proteomics. 10: 496-505. PMID 20013801 DOI: 10.1002/Pmic.200900346 |
0.389 |
|
| 2010 |
Hu Y, Wassermann AM, Lounkine E, Bajorath J. Systematic analysis of public domain compound potency data identifies selective molecular scaffolds across druggable target families. Journal of Medicinal Chemistry. 53: 752-8. PMID 20000355 DOI: 10.1021/Jm9014229 |
0.317 |
|
| 2010 |
Hu Y, Bajorath J. Global assessment of scaffold hopping potential for current pharmaceutical targets Medchemcomm. 1: 339-344. DOI: 10.1039/C0Md00156B |
0.344 |
|
| 2009 |
Lounkine E, Hu Y, Batista J, Bajorath J. Relevance of feature combinations for similarity searching using general or activity class-directed molecular fingerprints. Journal of Chemical Information and Modeling. 49: 561-70. PMID 19434896 DOI: 10.1021/Ci800377N |
0.305 |
|
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