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Isaac P. Forquer, Ph.D. - Publications

Affiliations: 
2008 Washington State University, Pullman, WA, United States 
Area:
Biochemistry
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Frueh L, Li Y, Mather M, Li Q, Pou S, Nilsen A, Winter RW, Forquer I, Pershing A, Xie LH, Smilkstein MJ, Caridha D, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, et al. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. Acs Infectious Diseases. PMID 28927276 DOI: 10.1021/Acsinfecdis.7B00062  0.43
2016 Ortiz D, Forquer I, Boitz J, Soysa R, Elya C, Fulwiler A, Nilsen A, Polley T, Riscoe MK, Ullman B, Landfear SM. Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs. Antimicrobial Agents and Chemotherapy. PMID 27297476 DOI: 10.1128/Aac.00850-16  0.465
2016 Lawres LA, Garg A, Kumar V, Bruzual I, Forquer IP, Renard I, Virji AZ, Boulard P, Rodriguez EX, Allen AJ, Pou S, Wegmann KW, Winter RW, Nilsen A, Mao J, et al. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. The Journal of Experimental Medicine. PMID 27270894 DOI: 10.1084/Jem.20151519  0.41
2016 Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK. Atovaquone and ELQ-300 combination therapy: A novel dual-site cytochrome bc1 inhibition strategy for malaria. Antimicrobial Agents and Chemotherapy. PMID 27270285 DOI: 10.1128/Aac.00791-16  0.439
2015 Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, et al. ELQ-300 prodrugs for enhanced delivery and single dose cure of malaria. Antimicrobial Agents and Chemotherapy. PMID 26124159 DOI: 10.1128/Aac.01183-15  0.373
2015 Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, et al. Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy. The American Journal of Tropical Medicine and Hygiene. 92: 1195-201. PMID 25918204 DOI: 10.4269/Ajtmh.14-0553  0.425
2015 Stickles AM, de Almeida MJ, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 59: 1977-82. PMID 25605352 DOI: 10.1128/Aac.04149-14  0.401
2014 Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, et al. Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers. Journal of Medicinal Chemistry. 57: 3818-34. PMID 24720377 DOI: 10.1021/Jm500147K  0.378
2013 Soysa R, Wilson ZN, Elferich J, Forquer I, Shinde U, Riscoe MK, Yates PA, Ullman B. Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs. The Journal of Biological Chemistry. 288: 29954-64. PMID 23986453 DOI: 10.1074/Jbc.M113.478826  0.361
2013 Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Science Translational Medicine. 5: 177ra37. PMID 23515079 DOI: 10.1126/Scitranslmed.3005029  0.463
2012 Doggett JS, Nilsen A, Forquer I, Wegmann KW, Jones-Brando L, Yolken RH, Bordón C, Charman SA, Katneni K, Schultz T, Burrows JN, Hinrichs DJ, Meunier B, Carruthers VB, Riscoe MK. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 15936-41. PMID 23019377 DOI: 10.1073/Pnas.1208069109  0.369
2011 Lee DW, Selamoglu N, Lanciano P, Cooley JW, Forquer I, Kramer DM, Daldal F. Loss of a conserved tyrosine residue of cytochrome b induces reactive oxygen species production by cytochrome bc1. The Journal of Biological Chemistry. 286: 18139-48. PMID 21454570 DOI: 10.1074/Jbc.M110.214460  0.451
2010 Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, ... ... Forquer I, et al. Chemical genetics of Plasmodium falciparum. Nature. 465: 311-5. PMID 20485428 DOI: 10.1038/Nature09099  0.412
2008 Smilkstein MJ, Forquer I, Kanazawa A, Kelly JX, Winter RW, Hinrichs DJ, Kramer DM, Riscoe MK. A drug-selected Plasmodium falciparum lacking the need for conventional electron transport. Molecular and Biochemical Parasitology. 159: 64-8. PMID 18308406 DOI: 10.1016/J.Molbiopara.2008.01.002  0.498
2006 Forquer I, Covian R, Bowman MK, Trumpower BL, Kramer DM. Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex. The Journal of Biological Chemistry. 281: 38459-65. PMID 17008316 DOI: 10.1074/Jbc.M605119200  0.444
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