Erwin F. Wagner, PhD (Dr. rer. nat. ) - Publications

BBVA Foundation – CNIO Cancer Cell Biology Programme CNIO, Madrid, Comunidad de Madrid, Spain 

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Year Citation  Score
2016 Uluçkan Ö, Jimenez M, Karbach S, Jeschke A, Graña O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, ... Wagner EF, et al. Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts. Science Translational Medicine. 8: 330ra37. PMID 27089206 DOI: 10.1126/scitranslmed.aad8996  1
2016 Petruzzelli M, Wagner EF. Mechanisms of metabolic dysfunction in cancer-associated cachexia. Genes & Development. 30: 489-501. PMID 26944676 DOI: 10.1101/gad.276733.115  1
2016 Wagner EF. Cancer: Fibroblasts for all seasons. Nature. 530: 42-3. PMID 26842052 DOI: 10.1038/530042a  1
2015 Uluçkan Ö, Guinea-Viniegra J, Jimenez M, Wagner EF. Signalling in inflammatory skin disease by AP-1 (Fos/Jun). Clinical and Experimental Rheumatology. 33: 44-9. PMID 26458100  1
2015 Wagner EF, Petruzzelli M. Cancer metabolism: A waste of insulin interference. Nature. 521: 430-1. PMID 26017439 DOI: 10.1038/521430a  1
2015 Uluçkan Ö, Bakiri L, Wagner EF. Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo. Methods in Molecular Biology (Clifton, N.J.). 1267: 297-305. PMID 25636475 DOI: 10.1007/978-1-4939-2297-0_14  1
2015 Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes & Development. 29: 144-56. PMID 25547114 DOI: 10.1101/gad.249748.114  1
2014 Hefetz-Sela S, Stein I, Klieger Y, Porat R, Sade-Feldman M, Zreik F, Nagler A, Pappo O, Quagliata L, Dazert E, Eferl R, Terracciano L, Wagner EF, Ben-Neriah Y, Baniyash M, et al. Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17582-7. PMID 25422452 DOI: 10.1073/pnas.1409700111  1
2014 Grötsch B, Brachs S, Lang C, Luther J, Derer A, Schlötzer-Schrehardt U, Bozec A, Fillatreau S, Berberich I, Hobeika E, Reth M, Wagner EF, Schett G, Mielenz D, David JP. The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells. The Journal of Experimental Medicine. 211: 2199-212. PMID 25288397 DOI: 10.1084/jem.20130795  1
2014 Glitzner E, Korosec A, Brunner PM, Drobits B, Amberg N, Schonthaler HB, Kopp T, Wagner EF, Stingl G, Holcmann M, Sibilia M. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. Embo Molecular Medicine. 6: 1312-27. PMID 25216727 DOI: 10.15252/emmm.201404114  1
2014 Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF. A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metabolism. 20: 433-47. PMID 25043816 DOI: 10.1016/j.cmet.2014.06.011  1
2014 Schulze J, Lopez-Contreras AJ, Uluçkan Ö, Graña-Castro O, Fernandez-Capetillo O, Wagner EF. Fos-dependent induction of Chk1 protects osteoblasts from replication stress. Cell Cycle (Georgetown, Tex.). 13: 1980-6. PMID 24762558 DOI: 10.4161/cc.28923  1
2014 Bakiri L, Hasenfuss SC, Wagner EF. A FATal AP-1 dimer switch in hepatosteatosis. Cell Cycle (Georgetown, Tex.). 13: 1218-9. PMID 24621495 DOI: 10.4161/cc.28514  1
2014 Guinea-Viniegra J, Jiménez M, Schonthaler HB, Navarro R, Delgado Y, Concha-Garzón MJ, Tschachler E, Obad S, Daudén E, Wagner EF. Targeting miR-21 to treat psoriasis. Science Translational Medicine. 6: 225re1. PMID 24574341 DOI: 10.1126/scitranslmed.3008089  1
2014 Alias S, Redwan B, Panzenböck A, Winter MP, Schubert U, Voswinckel R, Frey MK, Jakowitsch J, Alimohammadi A, Hobohm L, Mangold A, Bergmeister H, Sibilia M, Wagner EF, Mayer E, et al. Defective angiogenesis delays thrombus resolution: a potential pathogenetic mechanism underlying chronic thromboembolic pulmonary hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 810-9. PMID 24526692 DOI: 10.1161/ATVBAHA.113.302991  1
2014 Luther J, Ubieta K, Hannemann N, Jimenez M, Garcia M, Zech C, Schett G, Wagner EF, Bozec A. Fra-2/AP-1 controls adipocyte differentiation and survival by regulating PPARγ and hypoxia. Cell Death and Differentiation. 21: 655-64. PMID 24464219 DOI: 10.1038/cdd.2013.198  1
2014 Hasenfuss SC, Bakiri L, Thomsen MK, Williams EG, Auwerx J, Wagner EF. Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers. Cell Metabolism. 19: 84-95. PMID 24411941 DOI: 10.1016/j.cmet.2013.11.018  1
2014 Schumacher M, Schuster C, Rogon ZM, Bauer T, Caushaj N, Baars S, Szabowski S, Bauer C, Schorpp-Kistner M, Hess J, Holland-Cunz S, Wagner EF, Eils R, Angel P, Hartenstein B. Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts. The Journal of Investigative Dermatology. 134: 1332-41. PMID 24335928 DOI: 10.1038/jid.2013.535  1
2014 Palla AR, Piazzolla D, Abad M, Li H, Dominguez O, Schonthaler HB, Wagner EF, Serrano M. Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer. Oncogene. 33: 2513-9. PMID 23752184 DOI: 10.1038/onc.2013.196  1
2014 Hasenfuss SC, Bakiri L, Thomsen MK, Hamacher R, Wagner EF. Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism. Hepatology (Baltimore, Md.). 59: 261-73. PMID 23703832 DOI: 10.1002/hep.26518  1
2013 Schonthaler HB, Guinea-Viniegra J, Wculek SK, Ruppen I, Ximénez-Embún P, Guío-Carrión A, Navarro R, Hogg N, Ashman K, Wagner EF. S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3. Immunity. 39: 1171-81. PMID 24332034 DOI: 10.1016/j.immuni.2013.11.011  1
2013 Thomsen MK, Bakiri L, Hasenfuss SC, Hamacher R, Martinez L, Wagner EF. JUNB/AP-1 controls IFN-γ during inflammatory liver disease. The Journal of Clinical Investigation. 123: 5258-68. PMID 24200694 DOI: 10.1172/JCI70405  1
2013 Bozec A, Bakiri L, Jimenez M, Rosen ED, Catalá-Lehnen P, Schinke T, Schett G, Amling M, Wagner EF. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. Journal of Cell Science. 126: 5432-40. PMID 24046454 DOI: 10.1242/jcs.134510  1
2013 Windak R, Müller J, Felley A, Akhmedov A, Wagner EF, Pedrazzini T, Sumara G, Ricci R. The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart. Plos One. 8: e73294. PMID 24039904 DOI: 10.1371/journal.pone.0073294  1
2013 Briso EM, Guinea-Viniegra J, Bakiri L, Rogon Z, Petzelbauer P, Eils R, Wolf R, Rincón M, Angel P, Wagner EF. Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos. Genes & Development. 27: 1959-73. PMID 24029918 DOI: 10.1101/gad.223339.113  1
2013 Lefort K, Brooks Y, Ostano P, Cario-André M, Calpini V, Guinea-Viniegra J, Albinger-Hegyi A, Hoetzenecker W, Kolfschoten I, Wagner EF, Werner S, Dotto GP. A miR-34a-SIRT6 axis in the squamous cell differentiation network. The Embo Journal. 32: 2248-63. PMID 23860128 DOI: 10.1038/emboj.2013.156  1
2013 Bakiri L, Wagner EF. Mouse models for liver cancer. Molecular Oncology. 7: 206-23. PMID 23428636 DOI: 10.1016/j.molonc.2013.01.005  1
2012 Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, Chen L, Scheuch H, Zheng H, Qin L, Zatloukal K, Hui L, Wagner EF. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nature Cell Biology. 14: 1203-11. PMID 23041974 DOI: 10.1038/ncb2590  1
2012 Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, ... ... Wagner EF, et al. A validated regulatory network for Th17 cell specification. Cell. 151: 289-303. PMID 23021777 DOI: 10.1016/j.cell.2012.09.016  1
2012 Guinea-Viniegra J, Zenz R, Scheuch H, Jiménez M, Bakiri L, Petzelbauer P, Wagner EF. Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. The Journal of Clinical Investigation. 122: 2898-910. PMID 22772468 DOI: 10.1172/JCI63103  1
2012 Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED. FOSL2 promotes leptin gene expression in human and mouse adipocytes. The Journal of Clinical Investigation. 122: 1010-21. PMID 22326952 DOI: 10.1172/JCI58431  1
2012 Schultze SM, Mairhofer A, Li D, Cen J, Beug H, Wagner EF, Hui L. p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis. Cell Research. 22: 539-50. PMID 21946500 DOI: 10.1038/cr.2011.159  1
2012 Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ørntoft TF, Bakiri L, Wagner EF, Eizirik DL. Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation. Oncogene. 31: 1723-32. PMID 21841823 DOI: 10.1038/onc.2011.353  1
2011 Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nature Medicine. 17: 1231-4. PMID 21909105 DOI: 10.1038/nm.2452  1
2011 Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David JP. Elevated Fra-1 expression causes severe lipodystrophy. Journal of Cell Science. 124: 1465-76. PMID 21486951 DOI: 10.1242/jcs.079855  1
2011 Takada Y, Gresh L, Bozec A, Ikeda E, Kamiya K, Watanabe M, Kobayashi K, Asano K, Toyama Y, Wagner EF, Matsuo K. Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1. Oncogene. 30: 3821-32. PMID 21460858 DOI: 10.1038/onc.2011.101  1
2011 Schonthaler HB, Guinea-Viniegra J, Wagner EF. Targeting inflammation by modulating the Jun/AP-1 pathway. Annals of the Rheumatic Diseases. 70: i109-12. PMID 21339212 DOI: 10.1136/ard.2010.140533  1
2011 Fischer H, Szabo S, Scherz J, Jaeger K, Rossiter H, Buchberger M, Ghannadan M, Hermann M, Theussl HC, Tobin DJ, Wagner EF, Tschachler E, Eckhart L. Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. The Journal of Investigative Dermatology. 131: 1208-15. PMID 21307874 DOI: 10.1038/jid.2011.13  1
2011 Bakiri L, Reschke MO, Gefroh HA, Idarraga MH, Polzer K, Zenz R, Schett G, Wagner EF. Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 30: 1506-17. PMID 21119595 DOI: 10.1038/onc.2010.542  1
2011 Kenner L, Hoebertz A, Beil FT, Keon N, Karreth F, Eferl R, Scheuch H, Szremska A, Amling M, Schorpp-Kistner M, Angel P, Wagner EF. Mice lacking junB are osteopenic due to cell-autonomous osteoblast and osteoclast defects Journal of Cell Biology. 195: 1063. DOI: 10.1083/jcb.2003081551956c  1
2011 Wagner EF. Notch1 and corneal cell fate Developmental Cell. 21: e2. DOI: 10.1016/j.devcel.2011.11.016  1
2010 Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, Tanaka H, Pestell RG. C-jun inhibits mammary apoptosis in vivo. Molecular Biology of the Cell. 21: 4264-74. PMID 20926681 DOI: 10.1091/mbc.E10-08-0705  1
2010 Wagner EF, Schonthaler HB, Guinea-Viniegra J, Tschachler E. Psoriasis: what we have learned from mouse models. Nature Reviews. Rheumatology. 6: 704-14. PMID 20877306 DOI: 10.1038/nrrheum.2010.157  1
2010 Bozec A, Bakiri L, Jimenez M, Schinke T, Amling M, Wagner EF. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. The Journal of Cell Biology. 190: 1093-106. PMID 20837772 DOI: 10.1083/jcb.201002111  1
2010 Singh S, Vinson C, Gurley CM, Nolen GT, Beggs ML, Nagarajan R, Wagner EF, Parham DM, Peterson CA. Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant mice. The American Journal of Pathology. 177: 2055-66. PMID 20829439 DOI: 10.2353/ajpath.2010.091195  1
2010 Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF. Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death and Differentiation. 17: 1409-19. PMID 20300111 DOI: 10.1038/cdd.2010.22  1
2010 Grigoriadis AE, Kennedy M, Bozec A, Brunton F, Stenbeck G, Park IH, Wagner EF, Keller GM. Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood. 115: 2769-76. PMID 20065292 DOI: 10.1182/blood-2009-07-234690  1
2010 Reschke M, Ferby I, Stepniak E, Seitzer N, Horst D, Wagner EF, Ullrich A. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology (Baltimore, Md.). 51: 1383-90. PMID 20044804 DOI: 10.1002/hep.23428  1
2010 Takada Y, Ray N, Ikeda E, Kawaguchi T, Kuwahara M, Wagner EF, Matsuo K. Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB. Journal of Immunology (Baltimore, Md. : 1950). 184: 1014-21. PMID 20018614 DOI: 10.4049/jimmunol.0901196  1
2010 Wagner EF. Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun). Annals of the Rheumatic Diseases. 69: i86-88. PMID 19995753 DOI: 10.1136/ard.2009.119396  1
2009 Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF. Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proceedings of the National Academy of Sciences of the United States of America. 106: 21264-9. PMID 19995970 DOI: 10.1073/pnas.0907550106  1
2009 Guinea-Viniegra J, Zenz R, Scheuch H, Hnisz D, Holcmann M, Bakiri L, Schonthaler HB, Sibilia M, Wagner EF. TNFalpha shedding and epidermal inflammation are controlled by Jun proteins. Genes & Development. 23: 2663-74. PMID 19933155 DOI: 10.1101/gad.543109  1
2009 Pflegerl P, Vesely P, Hantusch B, Schlederer M, Zenz R, Janig E, Steiner G, Meixner A, Petzelbauer P, Wolf P, Soleiman A, Egger G, Moriggl R, Kishimoto T, Wagner EF, et al. Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 20423-8. PMID 19918056 DOI: 10.1073/pnas.0910371106  1
2009 Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nature Reviews. Cancer. 9: 537-49. PMID 19629069 DOI: 10.1038/nrc2694  1
2009 Julien M, Khoshniat S, Lacreusette A, Gatius M, Bozec A, Wagner EF, Wittrant Y, Masson M, Weiss P, Beck L, Magne D, Guicheux J. Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1856-68. PMID 19419315 DOI: 10.1359/jbmr.090508  1
2008 Hui L, Zatloukal K, Scheuch H, Stepniak E, Wagner EF. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. The Journal of Clinical Investigation. 118: 3943-53. PMID 19033664 DOI: 10.1172/JCI37156  1
2008 Yotova IY, Vlatkovic IM, Pauler FM, Warczok KE, Ambros PF, Oshimura M, Theussl HC, Gessler M, Wagner EF, Barlow DP. Identification of the human homolog of the imprinted mouse Air non-coding RNA. Genomics. 92: 464-73. PMID 18789384 DOI: 10.1016/j.ygeno.2008.08.004  1
2008 Durchdewald M, Guinea-Viniegra J, Haag D, Riehl A, Lichter P, Hahn M, Wagner EF, Angel P, Hess J. Podoplanin is a novel fos target gene in skin carcinogenesis. Cancer Research. 68: 6877-83. PMID 18757399 DOI: 10.1158/0008-5472.CAN-08-0299  1
2008 Gurzov EN, Ortis F, Bakiri L, Wagner EF, Eizirik DL. JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. Plos One. 3: e3030. PMID 18716665 DOI: 10.1371/journal.pone.0003030  1
2008 Hasselblatt P, Gresh L, Kudo H, Guinea-Viniegra J, Wagner EF. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene. 27: 6102-9. PMID 18679426 DOI: 10.1038/onc.2008.211  1
2008 Meixner A, Zenz R, Schonthaler HB, Kenner L, Scheuch H, Penninger JM, Wagner EF. Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nature Cell Biology. 10: 1003-11. PMID 18641637 DOI: 10.1038/ncb1761  1
2008 Ruiz-Bonilla V, Perdiguero E, Gresh L, Serrano AL, Zamora M, Sousa-Victor P, Jardí M, Wagner EF, Muñoz-Cánoves P. Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases. Cell Cycle (Georgetown, Tex.). 7: 2208-14. PMID 18641461  1
2008 Eferl R, Hasselblatt P, Rath M, Popper H, Zenz R, Komnenovic V, Idarraga MH, Kenner L, Wagner EF. Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proceedings of the National Academy of Sciences of the United States of America. 105: 10525-30. PMID 18641127 DOI: 10.1073/pnas.0801414105  1
2008 Gerlitz O, Wagner EF, Moreno E. When flies and mice develop cancer. Meeting on development and cancer. Embo Reports. 9: 730-4. PMID 18636085 DOI: 10.1038/embor.2008.137  1
2008 Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature Cell Biology. 10: 902-11. PMID 18604200 DOI: 10.1038/ncb1750  1
2008 Bozec A, Bakiri L, Hoebertz A, Eferl R, Schilling AF, Komnenovic V, Scheuch H, Priemel M, Stewart CL, Amling M, Wagner EF. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature. 454: 221-5. PMID 18548006 DOI: 10.1038/nature07019  1
2008 Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M. c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Molecular and Cellular Biology. 28: 4407-23. PMID 18443042 DOI: 10.1128/MCB.00535-07  1
2008 Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. The Journal of Biological Chemistry. 283: 12120-8. PMID 18281687 DOI: 10.1074/jbc.M800583200  1
2008 Kawamata A, Izu Y, Yokoyama H, Amagasa T, Wagner EF, Nakashima K, Ezura Y, Hayata T, Noda M. JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion. Journal of Cellular Biochemistry. 103: 1037-45. PMID 18240141 DOI: 10.1002/jcb.21660  1
2008 Zenz R, Eferl R, Scheinecker C, Redlich K, Smolen J, Schonthaler HB, Kenner L, Tschachler E, Wagner EF. Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Research & Therapy. 10: 201. PMID 18226189 DOI: 10.1186/ar2338  1
2008 Jiao X, Katiyar S, Liu M, Mueller SC, Lisanti MP, Li A, Pestell TG, Wu K, Ju X, Li Z, Wagner EF, Takeya T, Wang C, Pestell RG. Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase. Molecular Biology of the Cell. 19: 1378-90. PMID 18216279 DOI: 10.1091/mbc.E07-08-0753  1
2008 Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death and Differentiation. 15: 89-93. PMID 17762881 DOI: 10.1038/sj.cdd.4402222  1
2008 Gurzov EN, Bakiri L, Alfaro JM, Wagner EF, Izquierdo M. Targeting c-Jun and JunB proteins as potential anticancer cell therapy. Oncogene. 27: 641-52. PMID 17667939 DOI: 10.1038/sj.onc.1210690  1
2007 Hui L, Bakiri L, Stepniak E, Wagner EF. p38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle (Georgetown, Tex.). 6: 2429-33. PMID 17957136  1
2007 Hasselblatt P, Rath M, Komnenovic V, Zatloukal K, Wagner EF. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 104: 17105-10. PMID 17940019 DOI: 10.1073/pnas.0706272104  1
2007 Hanahan D, Wagner EF, Palmiter RD. The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer. Genes & Development. 21: 2258-70. PMID 17875663 DOI: 10.1101/gad.1583307  1
2007 Eferl R, Zenz R, Theussl HC, Wagner EF. Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis (New York, N.Y. : 2000). 45: 447-51. PMID 17607691 DOI: 10.1002/dvg.20311  1
2007 Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. The Journal of Biological Chemistry. 282: 18245-53. PMID 17485464 DOI: 10.1074/jbc.M610701200  1
2007 Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, Komnenovic V, Scheuch H, Beug H, Wagner EF. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nature Genetics. 39: 741-9. PMID 17468757 DOI: 10.1038/ng2033  1
2007 Vogel J, Weigand MA, Behrens A, Wagner EF, Schorpp-Kistner M, Zimmermann M, Schenkel J. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Research. 1151: 12-9. PMID 17428453 DOI: 10.1016/j.brainres.2007.03.023  1
2007 Perdiguero E, Ruiz-Bonilla V, Gresh L, Hui L, Ballestar E, Sousa-Victor P, Baeza-Raja B, Jardí M, Bosch-Comas A, Esteller M, Caelles C, Serrano AL, Wagner EF, Muñoz-Cánoves P. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. The Embo Journal. 26: 1245-56. PMID 17304211 DOI: 10.1038/sj.emboj.7601587  1
2007 Ott RG, Simma O, Kollmann K, Weisz E, Zebedin EM, Schorpp-Kistner M, Heller G, Zöchbauer S, Wagner EF, Freissmuth M, Sexl V. JunB is a gatekeeper for B-lymphoid leukemia. Oncogene. 26: 4863-71. PMID 17297445 DOI: 10.1038/sj.onc.1210285  1
2007 Bakiri L, Takada Y, Radolf M, Eferl R, Yaniv M, Wagner EF, Matsuo K. Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation. Bone. 40: 867-75. PMID 17189721 DOI: 10.1016/j.bone.2006.11.005  1
2007 Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG. Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor Molecular and Cellular Biology. 27: 1356-1369. PMID 17145782 DOI: 10.1128/MCB.01061-06  1
2006 Stepniak E, Ricci R, Eferl R, Sumara G, Sumara I, Rath M, Hui L, Wagner EF. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes & Development. 20: 2306-14. PMID 16912279 DOI: 10.1101/gad.390506  1
2006 Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (New York, N.Y.). 312: 734-7. PMID 16675698 DOI: 10.1126/science.1123965  1
2006 Wagner B, Natarajan A, Grünaug S, Kroismayr R, Wagner EF, Sibilia M. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. The Embo Journal. 25: 752-62. PMID 16467848 DOI: 10.1038/sj.emboj.7600988  1
2006 Zenz R, Wagner EF. Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors. The International Journal of Biochemistry & Cell Biology. 38: 1043-9. PMID 16423552 DOI: 10.1016/j.biocel.2005.11.011  1
2005 Wagner EF, Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunological Reviews. 208: 126-40. PMID 16313345 DOI: 10.1111/j.0105-2896.2005.00332.x  1
2005 Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. The Journal of Experimental Medicine. 202: 1261-9. PMID 16275763 DOI: 10.1084/jem.20051150  1
2005 Zenz R, Eferl R, Kenner L, Florin L, Hummerich L, Mehic D, Scheuch H, Angel P, Tschachler E, Wagner EF. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature. 437: 369-75. PMID 16163348 DOI: 10.1038/nature03963  1
2005 Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell. 122: 803-15. PMID 16143109 DOI: 10.1016/j.cell.2005.06.028  1
2005 Besirli CG, Wagner EF, Johnson EM. The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. The Journal of Cell Biology. 170: 401-11. PMID 16061693 DOI: 10.1083/jcb.200501138  1
2005 Terme M, Borg C, Guilhot F, Masurier C, Flament C, Wagner EF, Caillat-Zucman S, Bernheim A, Turhan AG, Caignard A, Zitvogel L. BCR/ABL promotes dendritic cell-mediated natural killer cell activation. Cancer Research. 65: 6409-17. PMID 16024645 DOI: 10.1158/0008-5472.CAN-04-2675  1
2005 Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. The Journal of Experimental Medicine. 201: 1677-87. PMID 15897281 DOI: 10.1084/jem.20042081  1
2005 Hayer S, Steiner G, Görtz B, Reiter E, Tohidast-Akrad M, Amling M, Hoffmann O, Redlich K, Zwerina J, Skriner K, Hilberg F, Wagner EF, Smolen JS, Schett G. CD44 is a determinant of inflammatory bone loss. The Journal of Experimental Medicine. 201: 903-14. PMID 15781582 DOI: 10.1084/jem.20040852  1
2005 David JP, Mehic D, Bakiri L, Schilling AF, Mandic V, Priemel M, Idarraga MH, Reschke MO, Hoffmann O, Amling M, Wagner EF. Essential role of RSK2 in c-Fos-dependent osteosarcoma development. The Journal of Clinical Investigation. 115: 664-72. PMID 15719069 DOI: 10.1172/JCI22877  1
2005 Ameyar-Zazoua M, Wisniewska MB, Bakiri L, Wagner EF, Yaniv M, Weitzman JB. AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene. Oncogene. 24: 2298-306. PMID 15688012 DOI: 10.1038/sj.onc.1208424  1
2005 Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, ... ... Wagner EF, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/gad.327005  1
2005 Mehic D, Bakiri L, Ghannadan M, Wagner EF, Tschachler E. Fos and jun proteins are specifically expressed during differentiation of human keratinocytes. The Journal of Investigative Dermatology. 124: 212-20. PMID 15654976 DOI: 10.1111/j.0022-202X.2004.23558.x  1
2005 Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, Bunting KD, Wagner EF, Sonneck K, Valent P, Ihle JN, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell. 7: 87-99. PMID 15652752 DOI: 10.1016/j.ccr.2004.12.010  1
2005 Köller M, Hayer S, Redlich K, Ricci R, David JP, Steiner G, Smolen JS, Wagner EF, Schett G. JNK1 is not essential for TNF-mediated joint disease. Arthritis Research & Therapy. 7: R166-73. PMID 15642137 DOI: 10.1186/ar1473  1
2004 Gass P, Fleischmann A, Hvalby O, Jensen V, Zacher C, Strekalova T, Kvello A, Wagner EF, Sprengel R. Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP. Brain Research. Molecular Brain Research. 130: 16-22. PMID 15519672 DOI: 10.1016/j.molbrainres.2004.07.004  1
2004 Raivich G, Bohatschek M, Da Costa C, Iwata O, Galiano M, Hristova M, Nateri AS, Makwana M, Riera-Sans L, Wolfer DP, Lipp HP, Aguzzi A, Wagner EF, Behrens A. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron. 43: 57-67. PMID 15233917 DOI: 10.1016/j.neuron.2004.06.005  1
2004 Rossiter H, Barresi C, Pammer J, Rendl M, Haigh J, Wagner EF, Tschachler E. Loss of vascular endothelial growth factor a activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation. Cancer Research. 64: 3508-16. PMID 15150105 DOI: 10.1158/0008-5472.CAN-03-2581  1
1983 Wagner EF, Covarrubias L, Stewart TA, Mintz B. Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell. 35: 647-55. PMID 6580963 DOI: 10.1016/0092-8674(83)90097-1  1
1982 Steward TA, Wagner EF, Mintz B. Human beta-globin gene sequences injected into mouse eggs, retained in adults, and transmitted to progeny. Science (New York, N.Y.). 217: 1046-8. PMID 6287575  1
1982 Wagner EF, Mintz B. Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene. Molecular and Cellular Biology. 2: 190-8. PMID 6287228  1
1981 Wagner EF, Stewart TA, Mintz B. The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proceedings of the National Academy of Sciences of the United States of America. 78: 5016-20. PMID 6272287  1
1980 Pellicer A, Wagner EF, el-Kareh A, Dewey MJ, Reuser AJ, Silverstein S, Axel R, Mintz B. Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 77: 2098-102. PMID 6246522  1
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