| Year |
Citation |
Score |
| 2021 |
Veith H, Zaeh M, Luebbert C, Rodríguez-Hornedo N, Sadowski G. Stability of Pharmaceutical Co-Crystals at Humid Conditions Can Be Predicted. Pharmaceutics. 13. PMID 33806996 DOI: 10.3390/pharmaceutics13030433 |
0.338 |
|
| 2020 |
Cavanagh KL, Kuminek G, Rodríguez-Hornedo N. Cocrystal Solubility Advantage and Dose/Solubility Ratio Diagrams: A Mechanistic Approach to Selecting Additives and Controlling Dissolution - Supersaturation - Precipitation Behavior. Molecular Pharmaceutics. PMID 32815731 DOI: 10.1021/Acs.Molpharmaceut.0C00713 |
0.335 |
|
| 2020 |
Machado TC, Kuminek G, Cardoso SG, Rodríguez-Hornedo N. The role of pH and dose/solubility ratio on cocrystal dissolution, drug supersaturation and precipitation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105422. PMID 32531350 DOI: 10.1016/J.Ejps.2020.105422 |
0.413 |
|
| 2019 |
Huang Y, Kuminek G, Roy L, Cavanagh KL, Yin Q, Rodríguez-Hornedo N. Cocrystal solubility advantage diagrams as a means to control dissolution, drug supersaturation and precipitation. Molecular Pharmaceutics. PMID 31318567 DOI: 10.1021/Acs.Molpharmaceut.9B00501 |
0.374 |
|
| 2019 |
Bermejo M, Kuminek G, Al-Gousous J, Ruiz-Picazo A, Tsume Y, Garcia-Arieta A, González-Alvarez I, Hens B, Amidon GE, Rodriguez-Hornedo N, Amidon GL, Mudie D. Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses. Pharmaceutics. 11. PMID 30884755 DOI: 10.3390/Pharmaceutics11030122 |
0.409 |
|
| 2019 |
Kuminek G, Cavanagh KL, Piedade MFMd, Rodríguez-Hornedo N. Posaconazole cocrystal with superior solubility and dissolution behavior Crystal Growth & Design. 19: 6592-6602. DOI: 10.1021/Acs.Cgd.9B01026 |
0.403 |
|
| 2018 |
Chen YM, Rodríguez-Hornedo N. Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug. Crystal Growth & Design. 18: 1358-1366. PMID 30505243 DOI: 10.1021/Acs.Cgd.7B01206 |
0.393 |
|
| 2018 |
Rzeczycki P, Woldemichael T, Willmer A, Murashov MD, Baik J, Keswani R, Yoon GS, Stringer KA, Rodriguez-Hornedo N, Rosania GR. An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism. Pharmaceutical Research. 36: 12. PMID 30421091 DOI: 10.1007/S11095-018-2539-6 |
0.311 |
|
| 2018 |
Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden KA, Wen B, Wysocki J, Löbenberg R, Lee A, et al. Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State. Molecular Pharmaceutics. PMID 30372084 DOI: 10.1021/Acs.Molpharmaceut.8B00515 |
0.336 |
|
| 2018 |
Cao F, Rodriguez-Hornedo N, Amidon GE. Mechanistic Analysis Of Co-Crystal Dissolution, Surface Ph, And Dissolution Advantage As A Guide For Rational Selection. Journal of Pharmaceutical Sciences. PMID 30278187 DOI: 10.1016/J.Xphs.2018.09.028 |
0.424 |
|
| 2018 |
Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, Amidon GE, Cavanagh K, Kuminek G, Benninghoff G, Fan J, Rodríguez-Hornedo N, Amidon GL. Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29378253 DOI: 10.1016/J.Ejps.2018.01.039 |
0.309 |
|
| 2018 |
Shimpi MR, Alhayali A, Cavanagh KL, Rodríguez-Hornedo N, Velaga SP. Tadalafil–Malonic Acid Cocrystal: Physicochemical Characterization, pH-Solubility, and Supersaturation Studies Crystal Growth & Design. 18: 4378-4387. DOI: 10.1021/Acs.Cgd.8B00362 |
0.472 |
|
| 2017 |
Kaur R, Cavanagh KL, Rodríguez-Hornedo N, Matzger AJ. Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties. Crystal Growth & Design. 17: 5012-5016. PMID 31537980 DOI: 10.1021/Acs.Cgd.7B00741 |
0.375 |
|
| 2017 |
Cavanagh KL, Maheshwari C, Rodríguez-Hornedo N. Understanding the differences between cocrystal and salt aqueous solubilities. Journal of Pharmaceutical Sciences. PMID 29097226 DOI: 10.1016/J.Xphs.2017.10.033 |
0.774 |
|
| 2017 |
Cao F, Amidon GL, Rodríguez-Hornedo N, Amidon GE. Mechanistic basis of cocrystal dissolution advantage. Journal of Pharmaceutical Sciences. PMID 28989017 DOI: 10.1016/J.Xphs.2017.09.014 |
0.348 |
|
| 2016 |
Kuminek G, Cao F, de Oliveira da Rocha AB, Cardoso SG, Rodríguez-Hornedo N. Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5. Advanced Drug Delivery Reviews. PMID 27137109 DOI: 10.1016/J.Addr.2016.04.022 |
0.419 |
|
| 2016 |
Kuminek G, Rodríguez-Hornedo N, Siedler S, Rocha HVA, Cuffini SL, Cardoso SG. How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability Chemical Communications. 52: 5832-5835. PMID 27042997 DOI: 10.1039/C6Cc00898D |
0.427 |
|
| 2016 |
Cao F, Amidon GL, Rodriguez-Hornedo N, Amidon GE. Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization. Molecular Pharmaceutics. PMID 26877267 DOI: 10.1021/Acs.Molpharmaceut.5B00862 |
0.387 |
|
| 2016 |
Bacchi A, Capucci D, Giannetto M, Mattarozzi M, Pelagatti P, Rodriguez-Hornedo N, Rubini K, Sala A. Turning Liquid Propofol into Solid (without Freezing It): Thermodynamic Characterization of Pharmaceutical Cocrystals Built with a Liquid Drug Crystal Growth & Design. 16: 6547-6555. DOI: 10.1021/Acs.Cgd.6B01241 |
0.428 |
|
| 2015 |
Lipert MP, Roy L, Childs SL, RodrÍguez-Hornedo N. Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization. Journal of Pharmaceutical Sciences. 104: 4153-63. PMID 26390213 DOI: 10.1002/Jps.24640 |
0.329 |
|
| 2015 |
Lipert MP, Rodríguez-Hornedo N. Cocrystal Transition Points: Role of Cocrystal Solubility, Drug Solubility, and Solubilizing Agents. Molecular Pharmaceutics. 12: 3535-46. PMID 26207517 DOI: 10.1021/Acs.Molpharmaceut.5B00111 |
0.349 |
|
| 2015 |
Keswani RK, Baik J, Yeomans L, Hitzman C, Johnson AM, Pawate AS, Kenis PJ, Rodriguez-Hornedo N, Stringer KA, Rosania GR. Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition. Molecular Pharmaceutics. 12: 2528-36. PMID 25926092 DOI: 10.1021/Acs.Molpharmaceut.5B00032 |
0.407 |
|
| 2012 |
Alhalaweh A, Roy L, Rodríguez-Hornedo N, Velaga SP. pH-dependent solubility of indomethacin-saccharin and carbamazepine-saccharin cocrystals in aqueous media. Molecular Pharmaceutics. 9: 2605-12. PMID 22867056 DOI: 10.1021/Mp300189B |
0.425 |
|
| 2012 |
Maheshwari C, André V, Reddy S, Roy L, Duarte T, Rodríguez-Hornedo N. Tailoring aqueous solubility of a highly soluble compound via cocrystallization: Effect of coformer ionization, pH max and solute-solvent interactions Crystengcomm. 14: 4801-4811. DOI: 10.1039/C2Ce06615G |
0.751 |
|
| 2012 |
Aitipamula S, Banerjee R, Bansal AK, Biradha K, Cheney ML, Choudhury AR, Desiraju GR, Dikundwar AG, Dubey R, Duggirala N, Ghogale PP, Ghosh S, Goswami PK, Goud NR, Jetti RRKR, ... ... Rodriguez-Hornedo N, et al. Polymorphs, salts, and cocrystals: What's in a name? Crystal Growth and Design. 12: 2147-2152. DOI: 10.1021/Cg3002948 |
0.356 |
|
| 2011 |
Huang N, Rodríguez-Hornedo N. Engineering cocrystal solubility, stability, and pH(max) by micellar solubilization. Journal of Pharmaceutical Sciences. 100: 5219-34. PMID 21910122 DOI: 10.1002/Jps.22725 |
0.626 |
|
| 2011 |
Duarte MT, André V, Grepioni F, Rodriguez-Hornedo N, Maheshwari C. Synthon competition in new pharmaceutical forms: how crystal structure affects properties Acta Crystallographica Section a Foundations of Crystallography. 67: C365-C365. DOI: 10.1107/S0108767311090817 |
0.708 |
|
| 2011 |
Huang N, Rodríguez-Hornedo N. Engineering cocrystal thermodynamic stability and eutectic points by micellar solubilization and ionization Crystengcomm. 13: 5409-5422. DOI: 10.1039/C1Ce05381G |
0.667 |
|
| 2011 |
Good D, Miranda C, Rodríguez-Hornedo N. Dependence of cocrystal formation and thermodynamic stability on moisture sorption by amorphous polymer Crystengcomm. 13: 1181-1189. DOI: 10.1039/C0Ce00592D |
0.416 |
|
| 2011 |
Alhalaweh A, Sokolowski A, Rodríguez-Hornedo N, Velaga SP. Solubility Behavior and Solution Chemistry of Indomethacin Cocrystals in Organic Solvents Crystal Growth & Design. 11: 3923-3929. DOI: 10.1021/Cg200517R |
0.408 |
|
| 2010 |
Jayasankar A, Roy L, Rodríguez-Hornedo N. Transformation pathways of cocrystal hydrates when coformer modulates water activity. Journal of Pharmaceutical Sciences. 99: 3977-85. PMID 20623694 DOI: 10.1002/Jps.22245 |
0.777 |
|
| 2010 |
Good DJ, Rodríguez-Hornedo N. Cocrystal eutectic constants and prediction of solubility behavior Crystal Growth and Design. 10: 1028-1032. DOI: 10.1021/Cg901232H |
0.418 |
|
| 2010 |
Huang N, Rodríguez-Hornedo N. Effect of Micellar Solubilization on Cocrystal Solubility and Stability Crystal Growth & Design. 10: 2050-2053. DOI: 10.1021/Cg1002176 |
0.619 |
|
| 2009 |
Maheshwari C, Jayasankar A, Khan NA, Amidon GE, Rodríguez-Hornedo N. Factors that influence the spontaneous formation of pharmaceutical cocrystals by simply mixing solid reactants Crystengcomm. 11: 493-500. DOI: 10.1039/B812264D |
0.723 |
|
| 2009 |
Kelly RC, Rodríguez-Hornedo N. Solvent effects on the crystallization and preferential nucleation of carbamazepine anhydrous polymorphs: A molecular recognition perspective Organic Process Research and Development. 13: 1291-1300. DOI: 10.1021/Op900133Z |
0.648 |
|
| 2009 |
Bethune SJ, Huang N, Jayasankar A, Rodríguez-Hornedo N. Understanding and predicting the effect of cocrystal components and pH on cocrystal solubility Crystal Growth and Design. 9: 3976-3988. DOI: 10.1021/Cg9001187 |
0.764 |
|
| 2009 |
Childs SL, Wood PA, Rodríguez-Hornedo N, Reddy LS, Hardcastle KI. Analysis of 50 crystal structures containing carbamazepine using the Materials module of Mercury CSD Crystal Growth and Design. 9: 1869-1888. DOI: 10.1021/Cg801056C |
0.318 |
|
| 2009 |
Jayasankar A, Reddy LS, Bethune SJ, Rodríguez-Hornedo N. Role of Cocrystal and Solution Chemistry on the Formation and Stability of Cocrystals with Different Stoichiometry Crystal Growth & Design. 9: 889-897. DOI: 10.1021/Cg800632R |
0.788 |
|
| 2009 |
Sreenivas Reddy L, Bethune SJ, Kampf JW, Rodríguez-Hornedo N. Cocrystals and salts of gabapentin: pH dependent cocrystal stability and solubility Crystal Growth and Design. 9: 378-385. DOI: 10.1021/Cg800587Y |
0.486 |
|
| 2008 |
Rodríguez-Spong B, Acciacca A, Fleisher D, Rodríguez-Hornedo N. PH-induced nanosegregation of ritonavir to lyotropic liquid crystal of higher solubility than crystalline polymorphs. Molecular Pharmaceutics. 5: 956-67. PMID 19434919 DOI: 10.1021/Mp800114K |
0.448 |
|
| 2008 |
Childs SL, Rodríguez-Hornedo N, Reddy LS, Jayasankar A, Maheshwari C, McCausland L, Shipplett R, Stahly BC. Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine Crystengcomm. 10: 856-864. DOI: 10.1039/B715396A |
0.737 |
|
| 2007 |
Seefeldt K, Miller J, Alvarez-Núñez F, Rodríguez-Hornedo N. Crystallization pathways and kinetics of carbamazepine-nicotinamide cocrystals from the amorphous state by in situ thermomicroscopy, spectroscopy, and calorimetry studies. Journal of Pharmaceutical Sciences. 96: 1147-58. PMID 17455346 DOI: 10.1002/Jps.20945 |
0.413 |
|
| 2006 |
Jayasankar A, Somwangthanaroj A, Shao ZJ, Rodríguez-Hornedo N. Cocrystal formation during cogrinding and storage is mediated by amorphous phase. Pharmaceutical Research. 23: 2381-92. PMID 16988890 DOI: 10.1007/S11095-006-9110-6 |
0.769 |
|
| 2006 |
Rodríguez-Hornedo N, Nehm SJ, Seefeldt KF, Pagan-Torres Y, Falkiewicz CJ. Reaction crystallization of pharmaceutical molecular complexes. Molecular Pharmaceutics. 3: 362-7. PMID 16749868 DOI: 10.1021/Mp050099M |
0.403 |
|
| 2006 |
Nehm SJ, Rodríguez-Spong B, Rodríguez-Hornedo N. Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation Crystal Growth & Design. 6: 592-600. DOI: 10.1021/Cg0503346 |
0.424 |
|
| 2004 |
Islam MT, Rodríguez-Hornedo N, Ciotti S, Ackermann C. Rheological characterization of topical carbomer gels neutralized to different pH. Pharmaceutical Research. 21: 1192-9. PMID 15290859 DOI: 10.1023/B:Pham.0000033006.11619.07 |
0.356 |
|
| 2004 |
Rodríguez-Spong B, Price CP, Jayasankar A, Matzger AJ, Rodríguez-Hornedo N. General principles of pharmaceutical solid polymorphism: a supramolecular perspective. Advanced Drug Delivery Reviews. 56: 241-74. PMID 14962581 DOI: 10.1016/J.Addr.2003.10.005 |
0.762 |
|
| 2004 |
Rodriguez-Spong B, Price CP, Jayasankar A, Matzger AJ, Rodriguez-Hornedo N. General Principles of Pharmaceutical Solid Polymorphism. A Supramolecular Perspective Cheminform. 35. DOI: 10.1002/CHIN.200437276 |
0.731 |
|
| 2003 |
Heimbach T, Oh DM, Li LY, Rodríguez-Hornedo N, Garcia G, Fleisher D. Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs. International Journal of Pharmaceutics. 261: 81-92. PMID 12878397 DOI: 10.1016/S0378-5173(03)00287-4 |
0.3 |
|
| 2003 |
Li LY, Rodríguez-Hornedo N, Heimbach T, Fleisher D. In-vitro crystallization of indinavir in the presence of ritonavir and as a function of pH. The Journal of Pharmacy and Pharmacology. 55: 707-11. PMID 12831515 DOI: 10.1211/002235703765344630 |
0.405 |
|
| 2003 |
Walsh RD, Bradner MW, Fleischman aS, Morales LA, Moulton aB, Rodríguez-Hornedo N, Zaworotko MJ. Crystal engineering of the composition of pharmaceutical phases. Chemical Communications (Cambridge, England). 186-7. PMID 12585383 DOI: 10.1039/B208574G |
0.411 |
|
| 2003 |
Fleischman SG, Kuduva SS, McMahon JA, Moulton B, Bailey Walsh RD, Rodríguez-Hornedo N, Zaworotko MJ. Crystal Engineering of the Composition of Pharmaceutical Phases: Multiple-Component Crystalline Solids Involving Carbamazepine Crystal Growth and Design. 3: 909-919. DOI: 10.1021/Cg034035X |
0.365 |
|
| 2002 |
Murphy D, Rodríguez-Cintrón F, Langevin B, Kelly RC, Rodríguez-Hornedo N. Solution-mediated phase transformation of anhydrous to dihydrate carbamazepine and the effect of lattice disorder. International Journal of Pharmaceutics. 246: 121-34. PMID 12270615 DOI: 10.1016/S0378-5173(02)00358-7 |
0.638 |
|
| 2001 |
Pikal-Cleland KA, Rodríguez-Hornedo N, Amidon GL, Carpenter JF. Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase. Archives of Biochemistry and Biophysics. 384: 398-406. PMID 11368330 DOI: 10.1006/Abbi.2000.2088 |
0.336 |
|
| 2001 |
Gómez G, Pikal MJ, Rodríguez-Hornedo N. Effect of initial buffer composition on pH changes during far-from-equilibrium freezing of sodium phosphate buffer solutions. Pharmaceutical Research. 18: 90-7. PMID 11336359 DOI: 10.1023/A:1011082911917 |
0.373 |
|
| 1995 |
Lechuga-Ballesteros D, Rodríguez-Hornedo N. Effects of molecular structure and growth kinetics on the morphology of l-alanine crystals International Journal of Pharmaceutics. 115: 151-160. DOI: 10.1016/0378-5173(94)00217-S |
0.323 |
|
| 1995 |
Lechuga-Ballesteros D, Rodríguez-Hornedo N. The influence of additives on the growth kinetics and mechanism of l-alanine crystals International Journal of Pharmaceutics. 115: 139-149. DOI: 10.1016/0378-5173(94)00216-R |
0.319 |
|
| 1993 |
Lechuga-Ballesteros D, Rodriguez-Hornedo N. Growth and Morphology of L-Alanine Crystals: Influence of Additive Adsorption Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 1008-1014. PMID 8378242 DOI: 10.1023/A:1018962722691 |
0.32 |
|
| 1993 |
Zipp GL, Rodriguez-Hornedo N. Growth mechanism and morphology of phenytoin and their relationship with crystallographic structure Journal of Physics D. 26. DOI: 10.1088/0022-3727/26/8B/007 |
0.366 |
|
| 1993 |
Zipp GL, Rodríguez-Hornedo N. The mechanism of phenytoin crystal growth International Journal of Pharmaceutics. 98: 189-201. DOI: 10.1016/0378-5173(93)90056-L |
0.326 |
|
| 1992 |
Rodríguez-Hornedo N, Lechuga-Ballesteros D, Wu H. Phase transition and heterogeneous/epitaxial nucleation of hydrated and anhydrous theophylline crystals International Journal of Pharmaceutics. 85: 149-162. DOI: 10.1016/0378-5173(92)90144-Q |
0.415 |
|
| 1992 |
Zipp GL, Rodriguez-Hornedo N. Phenytoin crystal growth rates in the presence of phosphate and chloride ions Journal of Crystal Growth. 123: 247-254. DOI: 10.1016/0022-0248(92)90030-M |
0.361 |
|
| 1991 |
Rodríguez-Hornedo N, Wu HJ. Crystal growth kinetics of theophylline monohydrate. Pharmaceutical Research. 8: 643-648. PMID 1866380 DOI: 10.1023/A:1015817109932 |
0.327 |
|
| 1991 |
Zipp GL, Rodriguez-Hornedo N. pH effects on the crystallization kinetics of phenytoin, a monoprotic acid Aiche Symposium Series. 87: 197-203. |
0.324 |
|
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