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Year Citation  Score
2015 Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, ... Varmus HE, et al. Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Cancer Discovery. 5: 534-49. PMID 25735773 DOI: 10.1158/2159-8290.CD-14-0750  0.36
2015 Collins FS, Varmus H. A new initiative on precision medicine New England Journal of Medicine. 372: 793-795. PMID 25635347 DOI: 10.1056/NEJMp1500523  1
2015 Abrams J, Kramer B, Doroshow JH, Varmus H. National Cancer Institute-supported clinical trials networks. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 293. PMID 25452448 DOI: 10.1200/JCO.2014.59.5421  1
2015 Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma Elife. 4: 1-23. DOI: 10.7554/eLife.06907  1
2014 Alberts B, Kirschner MW, Tilghman S, Varmus H. Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences of the United States of America. 111: 5773-7. PMID 24733905 DOI: 10.1073/pnas.1404402111  1
2014 de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, ... Varmus H, et al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discovery. 4: 606-19. PMID 24535670 DOI: 10.1158/2159-8290.CD-13-0741  1
2013 Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP. DOK2 inhibits EGFR-mutated lung adenocarcinoma. Plos One. 8: e79526. PMID 24255704 DOI: 10.1371/journal.pone.0079526  1
2013 Varmus H, Kumar HS. Addressing the growing international challenge of cancer: A multinational perspective Science Translational Medicine. 5. PMID 23467558 DOI: 10.1126/scitranslmed.3005899  1
2013 Sacco RL, Smith SC, Holmes D, Shurin S, Brawley O, Cazap E, Glass R, Komajda M, Koroshetz W, Mayer-Davis E, Mbanya JC, Sledge G, Varmus H. Accelerating progress on non-communicable diseases The Lancet. 382: e4-e5. PMID 21933747 DOI: 10.1016/S0140-6736(11)61477-3  1
2012 Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins Proceedings of the National Academy of Sciences of the United States of America. 109: 19408-19413. PMID 23129625 DOI: 10.1073/pnas.1216363109  1
2012 Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed. The Embo Journal. 31: 2670-84. PMID 22617420 DOI: 10.1038/emboj.2012.146  1
2012 Varmus H, Harlow E. Science funding: Provocative questions in cancer research. Nature. 481: 436-7. PMID 22281578 DOI: 10.1038/481436a  1
2012 Beverly LJ, Lockwood WW, Shah PP, Erdjument-Bromage H, Varmus H. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1 Proceedings of the National Academy of Sciences of the United States of America. 109: E119-E126. PMID 22233804 DOI: 10.1073/pnas.1119167109  1
2012 Varmus H. Arlen Specter: A retrospective Proceedings of the National Academy of Sciences of the United States of America. 109: 21178-21179. DOI: 10.1073/pnas.1219606110  1
2012 Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, ... ... Varmus H, et al. Uncensored exchange of scientific results (Proceedings of the National Academy of Sciences (2003) 100, 4, (1464) DOI: 10.1073/pnas.0630491100) Proceedings of the National Academy of Sciences of the United States of America. 109: 8352. DOI: 10.1073/pnas.1206993109  1
2011 Cohen JI, Fauci AS, Varmus H, Nabel GJ. Epstein-Barr virus: an important vaccine target for cancer prevention. Science Translational Medicine. 3: 107fs7. PMID 22049067 DOI: 10.1126/scitranslmed.3002878  1
2011 Du YCN, Chou CK, Klimstra DS, Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis Proceedings of the National Academy of Sciences of the United States of America. 108: 16753-16758. PMID 21940500 DOI: 10.1073/pnas.1114022108  1
2011 Varmus H, Trimble EL. Integrating cancer control into global health Science Translational Medicine. 3. PMID 21937755 DOI: 10.1126/scitranslmed.3002321  1
2011 Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proceedings of the National Academy of Sciences of the United States of America. 108: 16375-80. PMID 21930909 DOI: 10.1073/pnas.1113554108  1
2011 Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, ... ... Varmus HE, et al. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 20: 289-99. PMID 21907921 DOI: 10.1016/j.ccr.2011.08.007  1
2011 Varmus H. Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser Science (New York, N.Y.). 333: 397. PMID 21778374 DOI: 10.1126/science.333.6041.397  1
2011 Varmus H. NIH cancer chief wants more with less: by Meredith Wadman Nature. 475: 18. PMID 21734681 DOI: 10.1038/475018a  1
2010 Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, ... ... Varmus HE, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature Genetics. 42: 715-21. PMID 20601955 DOI: 10.1038/ng.619  1
2010 Varmus H. Ten years on - The human genome and medicine New England Journal of Medicine. 362: 2028-2029. PMID 20505183 DOI: 10.1056/NEJMe0911933  1
2010 Politi K, Fan PD, Shen R, Zakowski M, Varmus H. Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Disease Models & Mechanisms. 3: 111-9. PMID 20007486 DOI: 10.1242/dmm.003681  1
2009 Somwar R, Shum D, Djaballah H, Varmus H. Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells Journal of Biomolecular Screening. 14: 1176-1184. PMID 19887599 DOI: 10.1177/1087057109350919  1
2009 Du YCN, Klimstra DS, Varmus H. Activation of PyMT in β cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors Plos One. 4. PMID 19812721 DOI: 10.1371/journal.pone.0006932  1
2009 Jechlinger M, Podsypanina K, Varmus H. Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction Genes and Development. 23: 1677-1688. PMID 19605689 DOI: 10.1101/gad.1801809  1
2009 Gottfried K, Varmus H. The enlightenment returns. Science (New York, N.Y.). 323: 1538. PMID 19299588 DOI: 10.1126/science.1173563  1
2009 Asimakopoulos F, Varmus HE. Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. Journal of Virology. 83: 4835-43. PMID 19279099 DOI: 10.1128/JVI.02254-08  1
2009 Beverly LJ, Varmus HE. MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene. 28: 1274-9. PMID 19137012 DOI: 10.1038/onc.2008.466  1
2009 Varmus H. Science publishing and science libraries in the internet age Proceedings of the American Philosophical Society. 153: 160-184.  1
2008 Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, ... ... Varmus HE, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 455: 1069-75. PMID 18948947 DOI: 10.1038/nature07423  1
2008 Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE. Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proceedings of the National Academy of Sciences of the United States of America. 105: 14112-7. PMID 18776048 DOI: 10.1073/pnas.0806158105  1
2008 Podsypanina K, Du YCN, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H. Seeding and propagation of untransformed mouse mammary cells in the lung Science. 321: 1841-1844. PMID 18755941 DOI: 10.1126/science.1161621  1
2008 Varmus HE, Vogt PK, Bishop JM. The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973. Clinical Orthopaedics and Related Research. 466: 2031-8. PMID 18597148 DOI: 10.1007/s11999-008-0355-8  1
2008 Varmus H. Harold Varmus. Interview by Errol C. Friedberg Nature Reviews. Molecular Cell Biology. 9: 502-503. PMID 18578058 DOI: 10.1038/nrm2435  1
2008 Varmus H. NIH funds support more than a researcher's own lab Nature. 452: 811. PMID 18421329 DOI: 10.1038/452811b  1
2008 Varmus H. Progress toward public access to science Plos Biology. 6: 657-658. PMID 18399723 DOI: 10.1371/journal.pbio.0060101  1
2008 Podsypanina K, Politi K, Beverly LJ, Varmus HE. Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proceedings of the National Academy of Sciences of the United States of America. 105: 5242-7. PMID 18356293 DOI: 10.1073/pnas.0801197105  1
2008 Bishop JM, Hanahan D, Tlsty T, Hunter T, Lowe S, Varmus H, Dornbush KT, Waring JF, Jacks T, Gilmer T, Sherman M, Gerritsen W, Curran T, Doroshow J, Barrett JC, et al. The 20th Aspen Cancer Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention, and Cancer Therapy 2005 Molecular Carcinogenesis. 47: 707-732. PMID 18286481 DOI: 10.1002/mc.20214  1
2007 Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, ... ... Varmus HE, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature. 450: 893-8. PMID 17982442 DOI: 10.1038/nature06358  1
2007 Du YC, Lewis BC, Hanahan D, Varmus H. Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. Plos Biology. 5: e276. PMID 17941720 DOI: 10.1371/journal.pbio.0050276  1
2007 Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, Mardis ER, Wilson RK, Kris MG, ... ... Varmus H, et al. Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. Plos One. 2: e426. PMID 17487277 DOI: 10.1371/journal.pone.0000426  1
2006 Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proceedings of the National Academy of Sciences of the United States of America. 103: 17396-401. PMID 17090666 DOI: 10.1073/pnas.0608607103  1
2006 Varmus H. The new era in cancer research Science. 312: 1162-1165. PMID 16728627 DOI: 10.1126/science.1126758  1
2006 Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes & Development. 20: 1496-510. PMID 16705038 DOI: 10.1101/gad.1417406  1
2006 Bishop JM, Varmus H. Re-aim blame for NIH's hard times. Science (New York, N.Y.). 312: 499. PMID 16645053 DOI: 10.1126/science.1128904  1
2006 Varmus H. Time for a global science corps Scientist. 20: 24.  1
2005 Varmus H, Pao W, Politi K, Podsypanina K, Du YCN. Oncogenes come of age Cold Spring Harbor Symposia On Quantitative Biology. 70: 1-9. PMID 16869733 DOI: 10.1101/sqb.2005.70.039  1
2005 Varmus H, Stillman B. Support for the human cancer genome project [1] Science. 310: 1615. PMID 16339428  1
2005 Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biology. 6: R84. PMID 16207355 DOI: 10.1186/gb-2005-6-10-r84  1
2005 Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH, Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, ... ... Varmus H, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 102: 11011-6. PMID 16046538 DOI: 10.1073/pnas.0504952102  1
2005 Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain Plos Medicine. 2: 0225-0235. PMID 15737014 DOI: 10.1371/journal.pmed.0020073  1
2005 Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, Zakowski MF, Heelan RT, Kris MG, Varmus HE. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. Plos Medicine. 2: e17. PMID 15696205 DOI: 10.1371/journal.pmed.0020017  1
2005 Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA, Varmus HE. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Molecular and Cellular Biology. 25: 1228-37. PMID 15684377 DOI: 10.1128/MCB.25.4.1228-1237.2005  1
2005 Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. The Embo Journal. 24: 73-84. PMID 15592430 DOI: 10.1038/sj.emboj.7600460  1
2004 Cong F, Schweizer L, Varmus H. Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP Development. 131: 5103-5115. PMID 15459103 DOI: 10.1242/dev.01318  1
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, ... ... Varmus H, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/ng0904-921  1
2004 Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proceedings of the National Academy of Sciences of the United States of America. 101: 13306-11. PMID 15329413 DOI: 10.1073/pnas.0405220101  1
2004 Podsypanina K, Li Y, Varmus HE. Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. Bmc Medicine. 2: 24. PMID 15198801 DOI: 10.1186/1741-7015-2-24  1
2004 Zinkernagel RM. The challenges of an HIV vaccine enterprise. Science (New York, N.Y.). 303: 1294-7; author reply. PMID 14988536 DOI: 10.1126/science.303.5662.1294  1
2004 Cong F, Varmus H. Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin Proceedings of the National Academy of Sciences of the United States of America. 101: 2882-2887. PMID 14981260 DOI: 10.1073/pnas.0307344101  1
2004 Cong F, Schweizer L, Varmus H. Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled Molecular and Cellular Biology. 24: 2000-2011. PMID 14966280 DOI: 10.1128/MCB.24.5.2000-2011.2004  1
2004 Eisen MB, Brown PO, Varmus HE. PLoS Medicine - A medical journal for the internet age Plos Medicine. 1: 002-003. DOI: 10.1371/journal.pmed.0010031  1
2003 Lewis BC, Klimstra DS, Varmus HE. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes & Development. 17: 3127-38. PMID 14681205 DOI: 10.1101/gad.1140403  1
2003 Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 15853-8. PMID 14668450 DOI: 10.1073/pnas.2136825100  1
2003 Cong F, Schweizer L, Chamorro M, Varmus H. Requirement for a Nuclear Function of β-Catenin in Wnt Signaling Molecular and Cellular Biology. 23: 8462-8470. PMID 14612392 DOI: 10.1128/MCB.23.23.8462-8470.2003  1
2003 Varmus H. Genomic empowerment: the importance of public databases Nature Genetics. 35: 3. PMID 14578889 DOI: 10.1038/ng963  1
2003 Varmus H, Klausner R, Zerhouni E, Acharya T, Daar AS, Singer PA. Public health. Grand Challenges in Global Health. Science (New York, N.Y.). 302: 398-9. PMID 14563993 DOI: 10.1126/science.1091769  1
2003 Brown PO, Eisen MB, Varmus HE. Why PLoS became a publisher. Plos Biology. 1: E36. PMID 14551926 DOI: 10.1371/journal.pbio.0000036  1
2003 Cong F, Zhang J, Pao W, Zhou P, Varmus H. A protein knockdown strategy to study the function of β-catenin in tumorigenesis Bmc Molecular Biology. 4. PMID 14516475 DOI: 10.1186/1471-2199-4-10  1
2003 Pao W, Klimstra DS, Fisher GH, Varmus HE. Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. Proceedings of the National Academy of Sciences of the United States of America. 100: 8764-9. PMID 12857957 DOI: 10.1073/pnas.1133333100  1
2003 Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, ... ... Varmus H, et al. Medicine. The need for a global HIV vaccine enterprise. Science (New York, N.Y.). 300: 2036-9. PMID 12829768 DOI: 10.1126/science.1086916  1
2003 Schweizer L, Varmus H. Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors Bmc Cell Biology. 4. PMID 12729465 DOI: 10.1186/1471-2121-4-4  1
2003 Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, ... ... Varmus H, et al. Statement on scientific publication and security. Science (New York, N.Y.). 299: 1149. PMID 12595658 DOI: 10.1126/science.299.5610.1149  1
2002 Varmus H. Building a global culture of science Lancet. 360: s1-s4. PMID 12504480 DOI: 10.1016/S0140-6736(02)11796-X  1
2002 Varmus H. Getting ready for gene-based medicine New England Journal of Medicine. 347: 1526-1527. PMID 12421898 DOI: 10.1056/NEJMe020119  1
2002 Eisen MB, Brown PO, Varmus HE. Public-access group supports PubMed Central. Nature. 419: 111. PMID 12226637 DOI: 10.1038/419111c  1
2002 Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 1: 53-62. PMID 12086888 DOI: 10.1016/S1535-6108(01)00002-2  1
2002 Varmus H. The weaknesses of science for profit Oncologist. 7: 4-5. PMID 11854541 DOI: 10.1634/theoncologist.7-1-4  1
2001 Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & Development. 15: 3249-62. PMID 11751631 DOI: 10.1101/gad.947701  1
2001 Varmus H. How popular TV shows shape public perceptions of medical scientists Mount Sinai Journal of Medicine. 68: 346-349. PMID 11687861  1
2001 Lewis BC, Chinnasamy N, Morgan RA, Varmus HE. Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector. Journal of Virology. 75: 9339-44. PMID 11533197 DOI: 10.1128/JVI.75.19.9339-9344.2001  1
2001 Varmus H, Schaal B. Forum for agricultural biotechnology debates [4] Science. 292: 2252. PMID 11424946  1
2001 Burr R, Randerath K, Goldhaber P, Varmus H. The growing family of NIH institutes [1] Science. 292: 1835-1836. PMID 11398826  1
2001 Varmus H. A mover in the biomedical community. An interview with Harold Varmus, President of Memorial Sloan-Kettering Cancer Center in New York City and former Director of HIH Embo Reports. 2: 360-362. PMID 11375922  1
2001 Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. Bmc Immunology. 2: 3. PMID 11353545 DOI: 10.1186/1471-2172-2-3  1
2001 Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B. Information access. Building a "GenBank" of the published literature. Science (New York, N.Y.). 291: 2318-9. PMID 11269300  1
2001 Varmus H. Proliferation of National Institutes of Health Science. 291: 1903-1905. PMID 11245194 DOI: 10.1126/science.1059063  1
2001 Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HE. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. Bmc Molecular Biology. 2: 2. PMID 11178110  0.8
2001 Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & Development. 15: 241-53. PMID 11157779 DOI: 10.1101/gad.840301  1
2001 Varmus H. Harold Varmus [interview by Karen Birmingham] Nature Medicine. 7: 10. PMID 11135598  1
2001 Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HE. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice Bmc Molecular Biology. 2. DOI: 10.1186/1471-2199-2-2  1
2000 Varmus HE. The challenge of making laws on the shifting terrain of science. The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics. 28: 46-53. PMID 11244844  1
2000 Williams BO, Barish GD, Klymkowsky MW, Varmus HE. A comparative evaluation of beta-catenin and plakoglobin signaling activity. Oncogene. 19: 5720-8. PMID 11126358 DOI: 10.1038/sj.onc.1203921  1
2000 Nathan DG, Varmus HE. The National Institutes of Health and clinical research: a progress report. Nature Medicine. 6: 1201-4. PMID 11062519 DOI: 10.1038/81282  1
2000 Li Y, Hively WP, Varmus HE. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene. 19: 1002-9. PMID 10713683 DOI: 10.1038/sj.onc.1203273  1
2000 Varmus H. Ushering in a new age of scientific publishing Bmc News and Views. 1.  1
1999 Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular Cell. 4: 487-98. PMID 10549281 DOI: 10.1016/S1097-2765(00)80200-2  1
1999 Klymkowsky MW, Williams BO, Barish GD, Varmus HE, Vourgourakis YE. Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Molecular Biology of the Cell. 10: 3151-69. PMID 10512857  1
1999 Fisher GH, Orsulic S, Holland E, Hively WP, Li Y, Lewis BC, Williams BO, Varmus HE. Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene. 18: 5253-60. PMID 10498877 DOI: 10.1038/sj.onc.1203087  1
1999 Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (New York, N.Y.). 284: 638-41. PMID 10213685 DOI: 10.1126/science.284.5414.638  1
1999 Bocchinfuso WP, Hively WP, Couse JF, Varmus HE, Korach KS. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Research. 59: 1869-76. PMID 10213494  1
1999 Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Molecular and Cellular Biology. 19: 1498-507. PMID 9891083  1
1998 Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & Development. 12: 3675-85. PMID 9851974  1
1998 Holland EC, Hively WP, Gallo V, Varmus HE. Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes & Development. 12: 3644-9. PMID 9851971  1
1998 Varmus HE. National Institutes of Health in the tropics. The American Journal of Tropical Medicine and Hygiene. 59: 24-8. PMID 9684621  1
1998 Bates P, Rong L, Varmus HE, Young JA, Crittenden LB. Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus. Journal of Virology. 72: 2505-8. PMID 9499114  1
1998 Holland EC, Varmus HE. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 1218-23. PMID 9448312 DOI: 10.1073/pnas.95.3.1218  1
1997 Saint-Jeannet JP, He X, Varmus HE, Dawid IB. Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proceedings of the National Academy of Sciences of the United States of America. 94: 13713-8. PMID 9391091 DOI: 10.1073/pnas.94.25.13713  1
1997 Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes & Development. 11: 2835-44. PMID 9353253  1
1997 Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE, Donehower LA. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 829-38. PMID 9269892  1
1997 Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proceedings of the National Academy of Sciences of the United States of America. 94: 6770-5. PMID 9192640 DOI: 10.1073/pnas.94.13.6770  1
1996 Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Progress in Clinical and Biological Research. 395: 1-11. PMID 8895979  1
1996 Godley LA, Kopp JB, Eckhaus M, Paglino JJ, Owens J, Varmus HE. Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes & Development. 10: 836-50. PMID 8846920  1
1996 Chen X, Kang H, Shen LX, Chamorro M, Varmus HE, Tinoco I. A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA. Journal of Molecular Biology. 260: 479-83. PMID 8759314 DOI: 10.1006/jmbi.1996.0415  1
1996 Broccoli D, Godley LA, Donehower LA, Varmus HE, de Lange T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Molecular and Cellular Biology. 16: 3765-72. PMID 8668193  1
1996 Lowell CA, Niwa M, Soriano P, Varmus HE. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 87: 1780-92. PMID 8634424  1
1996 Leavitt AD, Robles G, Alesandro N, Varmus HE. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. Journal of Virology. 70: 721-8. PMID 8551608  1
1996 Shinar RZ, Sikorski RS, Varmus HE. In Vivo gene targeting to the mouse mammary gland using cationic lipids Journal of Investigative Medicine. 44: 166A.  1
1995 Taylor IC, Roy S, Varmus HE. Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation. Oncogene. 11: 2619-26. PMID 8545119  1
1995 Taylor IC, Roy S, Yaswen P, Stampfer MR, Varmus HE. Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase. The Journal of Biological Chemistry. 270: 6872-80. PMID 7896835 DOI: 10.1074/jbc.270.12.6872  1
1995 Chen X, Chamorro M, Lee SI, Shen LX, Hines JV, Tinoco I, Varmus HE. Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting. The Embo Journal. 14: 842-52. PMID 7882986  1
1995 Varmus HE. An overview of the FY-1996 budget for the National Institutes of Health. Academic Medicine : Journal of the Association of American Medical Colleges. 70: 385-7. PMID 7748383  1
1995 He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 374: 617-22. PMID 7715701 DOI: 10.1038/374617a0  1
1995 Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & Development. 9: 882-95. PMID 7705663  1
1995 Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D, Dracopoli NC. Mutations associated with familial melanoma impair p16INK4 function. Nature Genetics. 10: 114-6. PMID 7647780 DOI: 10.1038/ng0595-114  1
1995 Varmus HE. Harold E. Varmus, MD. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 43: 220-6. PMID 7614067  1
1995 Lee SI, Umen JG, Varmus HE. A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. Proceedings of the National Academy of Sciences of the United States of America. 92: 6587-91. PMID 7604038 DOI: 10.1073/pnas.92.14.6587  1
1995 Kaplan KB, Swedlow JR, Morgan DO, Varmus HE. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes & Development. 9: 1505-17. PMID 7541382  1
1995 Boeuf H, Murphy J, Bibbins KB, Varmus HE. Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation. Oncogene. 10: 433-8. PMID 7531318  1
1994 Verderame MF, Varmus HE. Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles. Oncogene. 9: 175-82. PMID 8302576  1
1994 Varmus HE, Lowell CA. Cancer genes and hematopoiesis. Blood. 83: 5-9. PMID 8274752  1
1994 Lowell CA, Soriano P, Varmus HE. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes & Development. 8: 387-98. PMID 8125254  1
1994 Gilbert JM, Bates P, Varmus HE, White JM. The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. Journal of Virology. 68: 5623-8. PMID 8057442  1
1994 Federspiel MJ, Bates P, Young JA, Varmus HE, Hughes SH. A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 91: 11241-5. PMID 7972042 DOI: 10.1073/pnas.91.23.11241  1
1994 Müller HP, Varmus HE. DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. The Embo Journal. 13: 4704-14. PMID 7925312  1
1994 Varmus HE, Godley LA, Roy S, Taylor IC, Yuschenkoff L, Shi YP, Pinkel D, Gray J, Pyle R, Aldaz CM. Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harbor Symposia On Quantitative Biology. 59: 491-9. PMID 7587104  1
1994 Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. The Embo Journal. 13: 4745-56. PMID 7525268  1
1993 Shackleford GM, Shivakumar S, Shiue L, Mason J, Kenyon C, Varmus HE. Two wnt genes in Caenorhabditis elegans. Oncogene. 8: 1857-64. PMID 8510930  1
1993 Leavitt AD, Shiue L, Varmus HE. Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. The Journal of Biological Chemistry. 268: 2113-9. PMID 8420982  1
1993 Bates P, Young JA, Varmus HE. A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. Cell. 74: 1043-51. PMID 8402880 DOI: 10.1016/0092-8674(93)90726-7  1
1993 Young JA, Bates P, Varmus HE. Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses. Journal of Virology. 67: 1811-6. PMID 8383211  1
1993 Shackleford GM, MacArthur CA, Kwan HC, Varmus HE. Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Proceedings of the National Academy of Sciences of the United States of America. 90: 740-4. PMID 8380647  1
1993 Shackleford GM, Willert K, Wang J, Varmus HE. The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells. Neuron. 11: 865-75. PMID 8240810 DOI: 10.1016/0896-6273(93)90116-9  1
1993 Parkin NT, Kitajewski J, Varmus HE. Activity of Wnt-1 as a transmembrane protein. Genes & Development. 7: 2181-93. PMID 8224845  1
1993 Müller HP, Pryciak PM, Varmus HE. Retroviral integration machinery as a probe for DNA structure and associated proteins. Cold Spring Harbor Symposia On Quantitative Biology. 58: 533-41. PMID 7956067  1
1993 Bibbins KB, Boeuf H, Varmus HE. Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Molecular and Cellular Biology. 13: 7278-87. PMID 7504171  1
1992 Nusse R, Varmus HE. Wnt genes. Cell. 69: 1073-87. PMID 1617723 DOI: 10.1016/0092-8674(92)90630-U  1
1992 Leavitt AD, Rose RB, Varmus HE. Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. Journal of Virology. 66: 2359-68. PMID 1548767  1
1992 Mason JO, Kitajewski J, Varmus HE. Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Molecular Biology of the Cell. 3: 521-33. PMID 1535241  1
1992 Kitajewski J, Mason JO, Varmus HE. Interaction of Wnt-1 proteins with the binding protein BiP. Molecular and Cellular Biology. 12: 784-90. PMID 1531088  1
1992 Jue SF, Bradley RS, Rudnicki JA, Varmus HE, Brown AM. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Molecular and Cellular Biology. 12: 321-8. PMID 1530877  1
1992 Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin TP, Muller WJ, Lee FS, Leder P, Varmus HE. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Molecular and Cellular Biology. 12: 147-54. PMID 1530875  1
1992 Kaplan KB, Swedlow JR, Varmus HE, Morgan DO. Association of p60c-src with endosomal membranes in mammalian fibroblasts. The Journal of Cell Biology. 118: 321-33. PMID 1378446  1
1992 Pryciak PM, Müller HP, Varmus HE. Simian virus 40 minichromosomes as targets for retroviral integration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 89: 9237-41. PMID 1329090  1
1992 Pryciak PM, Varmus HE. Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro. Journal of Virology. 66: 5959-66. PMID 1326652  1
1992 Parkin NT, Chamorro M, Varmus HE. Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo. Journal of Virology. 66: 5147-51. PMID 1321294  1
1992 Pryciak PM, Varmus HE. Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell. 69: 769-80. PMID 1317268 DOI: 10.1016/0092-8674(92)90289-O  1
1992 Pryciak PM, Sil A, Varmus HE. Retroviral integration into minichromosomes in vitro. The Embo Journal. 11: 291-303. PMID 1310932  1
1992 Chamorro M, Parkin N, Varmus HE. An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proceedings of the National Academy of Sciences of the United States of America. 89: 713-7. PMID 1309954  1
1992 Bourne HR, Varmus HE. Oncogenes and cell proliferation Current Opinion in Genetics and Development. 2: 1-3.  1
1991 Seeger C, Baldwin B, Hornbuckle WE, Yeager AE, Tennant BC, Cote P, Ferrell L, Ganem D, Varmus HE. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. Journal of Virology. 65: 1673-9. PMID 2002538  1
1991 Basu S, Varmus HE. Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of Virology. 65: 7086. PMID 1942261  1
1991 Morgan DO, Kaplan JM, Bishop JM, Varmus HE. Production of p60c-src by baculovirus expression and immunoaffinity purification. Methods in Enzymology. 200: 645-60. PMID 1720191 DOI: 10.1016/0076-6879(91)00177-X  1
1990 de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE. Structure and variability of human chromosome ends. Molecular and Cellular Biology. 10: 518-27. PMID 2300052  1
1990 Basu S, Varmus HE. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of Virology. 64: 5617-25. PMID 2214028  1
1990 Young JA, Bates P, Willert K, Varmus HE. Efficient incorporation of human CD4 protein into avian leukosis virus particles. Science (New York, N.Y.). 250: 1421-3. PMID 2175047  1
1990 Hirai H, Varmus HE. Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Molecular and Cellular Biology. 10: 1307-18. PMID 2108315  1
1990 Varmus HE. Nobel lecture. Retroviruses and oncogenes. I. Bioscience Reports. 10: 413-30. PMID 1704261 DOI: 10.1007/BF01152288  1
1990 Hirai H, Varmus HE. SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. Genes & Development. 4: 2342-52. PMID 1703982  1
1990 Hirai H, Varmus HE. Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 8592-6. PMID 1700434  1
1990 Chang LJ, Hirsch RC, Ganem D, Varmus HE. Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. Journal of Virology. 64: 5553-8. PMID 1698997  1
1990 Chang LJ, Ganem D, Varmus HE. Mechanism of translation of the hepadnaviral polymerase (P) gene. Proceedings of the National Academy of Sciences of the United States of America. 87: 5158-62. PMID 1695011  1
1990 Hirsch RC, Lavine JE, Chang LJ, Varmus HE, Ganem D. Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature. 344: 552-5. PMID 1690862 DOI: 10.1038/344552a0  1
1990 Kaplan JM, Varmus HE, Bishop JM. The src protein contains multiple domains for specific attachment to membranes. Molecular and Cellular Biology. 10: 1000-9. PMID 1689455  1
1989 Bowerman B, Brown PO, Bishop JM, Varmus HE. A nucleoprotein complex mediates the integration of retroviral DNA. Genes & Development. 3: 469-78. PMID 2721960  1
1989 Brown PO, Bowerman B, Varmus HE, Bishop JM. Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proceedings of the National Academy of Sciences of the United States of America. 86: 2525-9. PMID 2539592  1
1989 Morgan DO, Kaplan JM, Bishop JM, Varmus HE. Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell. 57: 775-86. PMID 2470513 DOI: 10.1016/0092-8674(89)90792-7  1
1989 Varmus HE. Reverse transcription in bacteria Cell. 56: 721-724. PMID 2466572 DOI: 10.1016/0092-8674(89)90673-9  1
1989 Chang LJ, Pryciak P, Ganem D, Varmus HE. Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature. 337: 364-8. PMID 2463489 DOI: 10.1038/337364a0  1
1989 Verderame MF, Kaplan JM, Varmus HE. A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner. Journal of Virology. 63: 338-48. PMID 2462061  1
1989 Bishop JM, Varmus HE. Nobel Price of Physiology and Medicine Epitheorese Klinikes Farmakologias Kai Farmakokinetikes. 7: 182-186.  1
1988 Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice Cell. 55: 619-625. PMID 3180222 DOI: 10.1016/0092-8674(88)90220-6  1
1988 Shackleford GM, Varmus HE. Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector Proceedings of the National Academy of Sciences of the United States of America. 85: 9655-9659. PMID 2849114  1
1988 Jacks T, Madhani HD, Masiarz FR, Varmus HE. Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region Cell. 55: 447-458. PMID 2846182 DOI: 10.1016/0092-8674(88)90031-1  1
1988 Kaplan JM, Mardon G, Bishop JM, Varmus HE. The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Molecular and Cellular Biology. 8: 2435-41. PMID 2841581  1
1988 Jacks T, Power MD, Masiarz FR, Luciw PA, Barr PJ, Varmus HE. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression Nature. 331: 280-283. PMID 2447506  1
1987 Sprengel R, Varmus HE, Ganem D. Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity. Virology. 159: 454-6. PMID 3617505 DOI: 10.1016/0042-6822(87)90486-7  1
1987 Shackleford GM, Varmus HE. Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos Cell. 50: 89-95. PMID 3594566 DOI: 10.1016/0092-8674(87)90665-9  1
1987 Persing DH, Varmus HE, Ganem D. The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid Journal of Virology. 61: 1672-1677. PMID 3573147  1
1987 Papkoff J, Brown AM, Varmus HE. The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway Molecular and Cellular Biology. 7: 3978-3984. PMID 3323883  1
1987 Chang C, Enders G, Sprengel R, Peters N, Varmus HE, Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. Journal of Virology. 61: 3322-5. PMID 3041052  1
1987 Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses Annual Review of Biochemistry. 56: 651-693. PMID 3039907  1
1987 Jacks T, Townsley K, Varmus HE, Majors J. Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins Proceedings of the National Academy of Sciences of the United States of America. 84: 4298-4302. PMID 3035577  1
1987 Nottenburg C, Stubblefield E, Varmus HE. An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA Journal of Virology. 61: 1828-1833. PMID 3033315  1
1987 Brown PO, Bowerman B, Varmus HE, Bishop JM. Correct integration of retroviral DNA in vitro. Cell. 49: 347-56. PMID 3032450 DOI: 10.1016/0092-8674(87)90287-X  1
1987 Brown AM, Papkoff J, Fung YK, Shackleford GM, Varmus HE. Identification of protein products encoded by the proto-oncogene int-1 Molecular and Cellular Biology. 7: 3971-3977. PMID 2828922  1
1987 Varmus HE. Oncogenes and transcriptional control Science. 238: 1337-1339. PMID 2825348  1
1987 Hagino-Yamagishi K, Donehower LA, Varmus HE. Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric Journal of Virology. 61: 1964-1971. PMID 2437326  1
1987 Enders GH, Ganem D, Varmus HE. 5'-Terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles Journal of Virology. 61: 35-41. PMID 2431165  1
1986 Seeger C, Ganem D, Varmus HE. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science (New York, N.Y.). 232: 477-84. PMID 3961490  1
1986 Persing DH, Varmus HE, Ganem D. Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide Science. 234: 1388-1391. PMID 3787251  1
1986 Brown AMC, Wildin RS, Prendergast TJ, Varmus HE. A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line Cell. 46: 1001-1009. PMID 3019559 DOI: 10.1016/0092-8674(86)90699-9  1
1986 Westaway D, Papkoff J, Moscovici C, Varmus HE. Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript The Embo Journal. 5: 301-309. PMID 3011401  1
1986 Nottenburg C, Varmus HE. Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas Molecular and Cellular Biology. 6: 2800-2806. PMID 2431293  1
1986 Jakobovits A, Shackelford GM, Varmus HE, Martin GR. Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development Proceedings of the National Academy of Sciences of the United States of America. 83: 7806-7810. PMID 2429320  1
1986 Persing DH, Varmus HE, Ganem D. Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus Journal of Virology. 60: 177-184. PMID 2427746  1
1985 Schwab M, Varmus HE, Bishop JM. Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature. 316: 160-2. PMID 4040214 DOI: 10.1038/316160a0  1
1985 Lin CC, Alitalo K, Schwab M, George D, Varmus HE, Bishop JM. Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines. Chromosoma. 92: 11-5. PMID 4006596 DOI: 10.1007/BF00327240  1
1985 Trueba D, Phelan M, Nelson J, Beck F, Pecha BS, Brown RJ, Varmus HE, Ganem D. Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts Hepatology. 5: 435-439. PMID 3997073 DOI: 10.1002/hep.1840050316  1
1985 Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage. Progress in Clinical and Biological Research. 175: 105-13. PMID 3991726  1
1985 Schwab M, Ramsay G, Alitalo K, Varmus HE, Bishop JM, Martinsson T, Levan G, Levan A. Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells. Nature. 315: 345-7. PMID 3889656 DOI: 10.1038/315345a0  1
1985 Persing DH, Varmus HE, Ganem D. A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin Proceedings of the National Academy of Sciences of the United States of America. 82: 3440-3444. PMID 3858831  1
1985 Lee WMF, Schwab M, Westaway D, Varmus HE. Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene Molecular and Cellular Biology. 5: 3345-3356. PMID 3837844  1
1985 Fung YKT, Shackleford GM, Brown AMC, Sanders GS, Varmus HE. Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene Molecular and Cellular Biology. 5: 3337-3344. PMID 3018519  1
1985 Varmus HE. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia Cancer. 55: 2324-2328. PMID 2985231  1
1985 Mossie KG, Young MW, Varmus HE. Extrachromosomal DNA forms of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos. Journal of Molecular Biology. 182: 31-43. PMID 2582138 DOI: 10.1016/0022-2836(85)90025-7  1
1985 Varmus HE. Molecular biology: Reverse transcriptase rides again Nature. 314: 583-584. PMID 2581138 DOI: 10.1038/314583a0  1
1985 Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM. Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Molecular and Cellular Biology. 5: 831-8. PMID 2581127  1
1985 Jacks T, Varmus HE. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting Science. 230: 1237-1242. PMID 2416054  1
1984 Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (New York, N.Y.). 224: 1121-4. PMID 6719137  1
1984 Schwab M, Varmus HE, Bishop JM, Grzeschik KH, Naylor SL, Sakaguchi AY, Brodeur G, Trent J. Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature. 308: 288-91. PMID 6700732 DOI: 10.1038/308288a0  1
1984 Schwab M, Ellison J, Busch M, Rosenau W, Varmus HE, Bishop JM. Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America. 81: 4940-4. PMID 6589638  0.92
1984 Parker RC, Varmus HE, Bishop JM. Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell. 37: 131-9. PMID 6426802 DOI: 10.1016/0092-8674(84)90308-8  1
1984 Varmus HE. The molecular genetics of cellular oncogenes Annual Review of Genetics. 18: 553-612. PMID 6397126  1
1984 Westaway D, Payne G, Varmus HE. Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors Proceedings of the National Academy of Sciences of the United States of America. 81: 843-847. PMID 6322173  1
1984 Donehower LA, Varmus HE. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration Proceedings of the National Academy of Sciences of the United States of America. 81: 6461-6465. PMID 6208550  1
1984 Standring DN, Rutter WJ, Varmus HE, Ganem D. Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region Journal of Virology. 50: 563-571. PMID 6200609  1
1984 Luciw PA, Oppermann H, Bishop JM, Varmus HE. Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells. Molecular and Cellular Biology. 4: 1260-9. PMID 6095056  1
1984 Jakobovits EB, Majors JE, Varmus HE. Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation Cell. 38: 757-765. PMID 6091899 DOI: 10.1016/0092-8674(84)90271-X  1
1984 Seeger C, Ganem D, Varmus HE. The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proceedings of the National Academy of Sciences of the United States of America. 81: 5849-52. PMID 6091114  1
1984 Seeger C, Ganem D, Varmus HE. Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. Journal of Virology. 51: 367-75. PMID 6086950  1
1983 Schwab M, Alitalo K, Klempnauer KH, Varmus HE, Bishop JM, Gilbert F, Brodeur G, Goldstein M, Trent J. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature. 305: 245-8. PMID 6888561  0.92
1983 Weiser B, Ganem D, Seeger C, Varmus HE. Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. Journal of Virology. 48: 1-9. PMID 6887347  1
1983 Varmus HE. Using retroviruses as insertional mutagens to identify cellular oncogenes Progress in Clinical and Biological Research. 119: 23-35. PMID 6867028  1
1983 Majors JE, Varmus HE. Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene Journal of Virology. 47: 495-504. PMID 6312081  1
1983 Majors J, Varmus HE. A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene Proceedings of the National Academy of Sciences of the United States of America. 80: 5866-5870. PMID 6310597  1
1983 Luciw PA, Bishop JM, Varmus HE, Capecchi MR. Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell. 33: 705-16. PMID 6307525 DOI: 10.1016/0092-8674(83)90013-2  1
1983 Schwab M, Alitalo K, Varmus HE, Bishop JM, George D. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature. 303: 497-501. PMID 6304530 DOI: 10.1038/303497a0  1
1983 Swanstrom R, Parker RC, Varmus HE, Bishop JM. Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 80: 2519-23. PMID 6302692  1
1983 Alitalo K, Schwab M, Lin CC, Varmus HE, Bishop JM. Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 80: 1707-11. PMID 6300869  1
1983 Mardon G, Varmus HE. Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins. Cell. 32: 871-9. PMID 6299579 DOI: 10.1016/0092-8674(83)90072-7  1
1983 Czernilofsky AP, Levinson AD, Varmus HE, Bishop JM, Tischer E, Goodman H. Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. Nature. 301: 736-8. PMID 6298633 DOI: 10.1038/301736b0  1
1982 Ganem D, Weiser B, Barchuk A, Brown RJ, Varmus HE. Biological characterization of acute infection with ground squirrel hepatitis virus Journal of Virology. 44: 366-373. PMID 7143570  1
1982 Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome Cell. 31: 99-109. PMID 6297757 DOI: 10.1016/0092-8674(82)90409-3  1
1982 Ganem D, Greenbaum L, Varmus HE. Virion DNA of ground squirrel hepatitis virus: Structural analysis and molecular cloning Journal of Virology. 44: 374-383. PMID 6292498  1
1982 Swanstrom R, Bishop JM, Varmus HE. Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo. Journal of Virology. 42: 337-41. PMID 6283154  1
1982 Swanstrom R, Varmus HE, Bishop JM. Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus. Journal of Virology. 41: 535-41. PMID 6281465  1
1982 Hackett PB, Swanstrom R, Varmus HE, Bishop JM. The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides. Journal of Virology. 41: 527-34. PMID 6281464  1
1982 Payne GS, Bishop JM, Varmus HE. Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature. 295: 209-14. PMID 6276760  1
1982 Varmus HE. A growing role for reverse transcription Nature. 299: 204-205. PMID 6180324 DOI: 10.1038/299204a0  1
1982 Varmus HE. Form and function of retroviral proviruses Science. 216: 812-820. PMID 6177038  1
1981 Coffin JM, Varmus HE, Bishop JM, Essex M, Hardy WD, Martin GS, Rosenberg NE, Scolnick EM, Weinberg RA, Vogt PK. Proposal for naming host cell-derived inserts in retrovirus genomes. Journal of Virology. 40: 953-7. PMID 7321107  1
1981 Robertson DL, Varmus HE. Dexamethasone induction of the intracellular RNAs of mouse mammary tumor virus Journal of Virology. 40: 673-682. PMID 6275112  1
1981 Ross NL, DeLorbe W, Varmus HE, Bishop JM, Brahic M, Haase A. Persistence and expression of Marek's disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization. The Journal of General Virology. 57: 285-96. PMID 6275026 DOI: 10.1099/0022-1317-57-2-285  1
1981 Parker RC, Varmus HE, Bishop JM. Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. Proceedings of the National Academy of Sciences of the United States of America. 78: 5842-6. PMID 6272320  1
1981 Hughes SH, Mutschler A, Bishop JM, Varmus HE. A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration. Proceedings of the National Academy of Sciences of the United States of America. 78: 4299-303. PMID 6270669  1
1981 Baker B, Robison H, Varmus HE, Bishop JM. Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression. Virology. 114: 8-22. PMID 6269293 DOI: 10.1016/0042-6822(81)90248-8  1
1981 Majors JE, Swanstrom R, DeLorbe WJ, Payne GS, Hughes SH, Ortiz S, Quintrell N, Bishop JM, Varmus HE. DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements. Cold Spring Harbor Symposia On Quantitative Biology. 45: 731-8. PMID 6266765  1
1971 Pastan I, Perlman RL, Emmer M, Varmus HE, DeCrombrugghe B, Chen BP, Parks J. Regulation of gene expression in Escherichia coli by cyclic AMP. Recent Progress in Hormone Research. 27: 421-32. PMID 4336400  1
1971 Miller Z, Varmus HE, Parks JS, Perlman RL, Pastan I. Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. The Journal of Biological Chemistry. 246: 2898-903. PMID 4324343  1
1971 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in antibiotic-treated E. coli. Nature: New Biology. 230: 41-4. PMID 4324113  1
1971 De Crombrugghe B, Chen B, Gottesman M, Pastan I, Varmus HE, Emmer M, Perlman RL. Regulation of lac mRNA synthesis in a soluble cell-free system. Nature: New Biology. 230: 37-40. PMID 4324112  1
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. The Journal of Biological Chemistry. 245: 6366-72. PMID 4320837  1
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. The Journal of Biological Chemistry. 245: 2259-67. PMID 4315149  1
1970 de Crombrugghe B, Varmus HE, Perlman RL, Pastan IH. Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochemical and Biophysical Research Communications. 38: 894-901. PMID 4314384 DOI: 10.1016/0006-291X(70)90805-3  1
1969 De Crombrugghe B, Perlman RL, Varmus HE, Pastan I. Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. The Journal of Biological Chemistry. 244: 5828-35. PMID 4310825  1
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