| Year |
Citation |
Score |
| 2024 |
Son MY, Belan O, Spirek M, Cibulka J, Nikulenkov F, Kim YY, Hwang S, Myung K, Montagna C, Kim TM, Krejci L, Hasty P. RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair. Iscience. 27: 109524. PMID 38577109 DOI: 10.1016/j.isci.2024.109524 |
0.347 |
|
| 2024 |
Marple T, Son MY, Cheng X, Ko JH, Sung P, Hasty P. TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis. Cell Reports. 43: 113637. PMID 38175749 DOI: 10.1016/j.celrep.2023.113637 |
0.411 |
|
| 2021 |
Hasty P. Trex2 responds to damaged replication forks in diverse ways. Molecular & Cellular Oncology. 8: 1881394. PMID 33860084 DOI: 10.1080/23723556.2021.1881394 |
0.302 |
|
| 2021 |
Baroni M, Yi C, Choudhary S, Lei X, Kosti A, Grieshober D, Velasco M, Qiao M, Burns SS, Araujo PR, DeLambre T, Son MY, Plateroti M, Ferreira MAR, Hasty P, et al. Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes. Cancers. 13. PMID 33804958 DOI: 10.3390/cancers13071494 |
0.322 |
|
| 2020 |
Ko JH, Son MY, Zhou Q, Molnarova L, Song L, Mlcouskova J, Jekabsons A, Montagna C, Krejci L, Hasty P. TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51. Cell Reports. 33: 108543. PMID 33357432 DOI: 10.1016/j.celrep.2020.108543 |
0.351 |
|
| 2020 |
Parihar M, Dodds SG, Hubbard G, Javors MA, Strong R, Hasty P, Sharp ZD. Rapamycin Extends Life Span in Apc Colon Cancer FAP Model. Clinical Colorectal Cancer. PMID 33132009 DOI: 10.1016/J.Clcc.2020.08.006 |
0.321 |
|
| 2020 |
Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P. Acarbose improved survival for Apc mice. Aging Cell. e13088. PMID 31903726 DOI: 10.1111/Acel.13088 |
0.343 |
|
| 2019 |
Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Aging Cell. e13072. PMID 31737985 DOI: 10.1111/Acel.13072 |
0.491 |
|
| 2018 |
Son MY, Hasty P. Homologous recombination defects and how they affect replication fork maintenance. Aims Genetics. 5: 192-211. PMID 31435521 DOI: 10.3934/genet.2018.4.192 |
0.324 |
|
| 2018 |
Seol JH, Holland C, Li X, Kim C, Li F, Medina-Rivera M, Eichmiller R, Gallardo IF, Finkelstein IJ, Hasty P, Shim EY, Surtees JA, Lee SE. Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair. Nature Communications. 9: 2025. PMID 29795289 DOI: 10.1038/S41467-018-04327-0 |
0.445 |
|
| 2016 |
Hasty P, Campisi J, Sharp ZD. Do p53 stress responses impact organismal aging? Translational Cancer Research. 5: 685-691. PMID 30984573 DOI: 10.21037/Tcr.2016.12.02 |
0.354 |
|
| 2016 |
Young Son M, Deng CX, Hoeijmarkers JH, Rebel VI, Hasty P. A mechanism for 1,4-Benzoquinone-induced genotoxicity. Oncotarget. PMID 27340773 DOI: 10.18632/Oncotarget.10184 |
0.49 |
|
| 2015 |
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell. PMID 26315673 DOI: 10.1111/Acel.12380 |
0.357 |
|
| 2015 |
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. p53 and rapamycin are additive. Oncotarget. PMID 26158292 DOI: 10.18632/Oncotarget.4602 |
0.363 |
|
| 2015 |
Ngo J, Matsuyama M, Kim C, Poventud-Fuentes I, Bates A, Siedlak SL, Lee HG, Doughman YQ, Watanabe M, Liner A, Hoit B, Voelkel N, Gerson S, Hasty P, Matsuyama S. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death & Disease. 6: e1706. PMID 25811803 DOI: 10.1038/Cddis.2015.11 |
0.424 |
|
| 2015 |
Dao V, Pandeswara S, Liu Y, Hurez V, Dodds S, Callaway D, Liu A, Hasty P, Sharp ZD, Curiel TJ. Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage. Cancer Prevention Research (Philadelphia, Pa.). 8: 400-9. PMID 25736275 DOI: 10.1158/1940-6207.Capr-14-0313-T |
0.421 |
|
| 2015 |
Zhou T, Chen P, Gu J, Bishop AJ, Scott LM, Hasty P, Rebel VI. Potential relationship between inadequate response to DNA damage and development of myelodysplastic syndrome. International Journal of Molecular Sciences. 16: 966-89. PMID 25569081 DOI: 10.3390/Ijms16010966 |
0.433 |
|
| 2015 |
Kim TM, Son MY, Dodds S, Hu L, Luo G, Hasty P. RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. Nucleic Acids Research. 43: 893-903. PMID 25520194 DOI: 10.1093/Nar/Gku1334 |
0.473 |
|
| 2014 |
Hasty P, Montagna C. Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms. Molecular & Cellular Oncology. 1. PMID 26203462 DOI: 10.4161/Mco.29904 |
0.403 |
|
| 2014 |
Kim TM, Son MY, Dodds S, Hu L, Hasty P. Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks. Mutation Research. 766: 66-72. PMID 25847274 DOI: 10.1016/J.Mrfmmm.2014.06.003 |
0.478 |
|
| 2014 |
Kim TM, Son MY, Dodds S, Hu L, Hasty P. Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks. Mutation Research. 766: 66-72. PMID 25773776 DOI: 10.1016/j.mrfmmm.2014.06.003 |
0.379 |
|
| 2014 |
Nair BC, Krishnan SR, Sareddy GR, Mann M, Xu B, Natarajan M, Hasty P, Brann D, Tekmal RR, Vadlamudi RK. Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell Death and Differentiation. 21: 1409-18. PMID 24786831 DOI: 10.1038/Cdd.2014.55 |
0.411 |
|
| 2014 |
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P. The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency. Plos One. 9: e93568. PMID 24740260 DOI: 10.1371/Journal.Pone.0093568 |
0.498 |
|
| 2014 |
Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair. Plos One. 9: e86358. PMID 24466051 DOI: 10.1371/Journal.Pone.0086358 |
0.513 |
|
| 2014 |
Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. eRapa restores a normal life span in a FAP mouse model. Cancer Prevention Research (Philadelphia, Pa.). 7: 169-78. PMID 24282255 DOI: 10.1158/1940-6207.Capr-13-0299 |
0.415 |
|
| 2014 |
Dao V, Pandeswara SL, Cardenas K, Hurez V, Dodds S, Liu Y, Liu A, Dave Sharp Z, Hasty P, Curiel TJ. 35 Cytokine. 70: 36. DOI: 10.1016/J.Cyto.2014.07.042 |
0.363 |
|
| 2013 |
Ozer Z, Qazi S, Ishkhanian R, Hasty P, Ma H, Uckun FM. KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION. International Journal of Molecular Medical Science. 3: 50-64. PMID 24478815 DOI: 10.5376/Ijmms.2013.03.0007 |
0.384 |
|
| 2013 |
Gravina S, Dollé ME, Wang T, van Steeg H, Hasty P, Hoeijmakers J, Vijg J. High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice. Plos One. 8: e73496. PMID 24039963 DOI: 10.1371/Journal.Pone.0073496 |
0.411 |
|
| 2013 |
Hu L, Kim TM, Son MY, Kim SA, Holland CL, Tateishi S, Kim DH, Yew PR, Montagna C, Dumitrache LC, Hasty P. Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes. Nature. 501: 569-72. PMID 24013173 DOI: 10.1038/Nature12500 |
0.483 |
|
| 2013 |
Zhou T, Hasty P, Walter CA, Bishop AJ, Scott LM, Rebel VI. Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA? Experimental Hematology. 41: 665-74. PMID 23643835 DOI: 10.1016/J.Exphem.2013.04.008 |
0.442 |
|
| 2013 |
Kim TM, Rebel VI, Hasty P. Defining a genotoxic profile with mouse embryonic stem cells. Experimental Biology and Medicine (Maywood, N.J.). 238: 285-93. PMID 23598974 DOI: 10.1177/1535370213480700 |
0.476 |
|
| 2013 |
Li H, Marple T, Hasty P. Ku80-deleted cells are defective at base excision repair. Mutation Research. 745: 16-25. PMID 23567907 DOI: 10.1016/J.Mrfmmm.2013.03.010 |
0.449 |
|
| 2013 |
Maslov AY, Ganapathi S, Westerhof M, Quispe-Tintaya W, White RR, Van Houten B, Reiling E, Dollé ME, van Steeg H, Hasty P, Hoeijmakers JH, Vijg J. DNA damage in normally and prematurely aged mice. Aging Cell. 12: 467-77. PMID 23496256 DOI: 10.1111/Acel.12071 |
0.48 |
|
| 2013 |
Hasty P, Sharp ZD, Curiel TJ, Campisi J. mTORC1 and p53: clash of the gods? Cell Cycle (Georgetown, Tex.). 12: 20-5. PMID 23255104 DOI: 10.4161/Cc.22912 |
0.395 |
|
| 2013 |
Dao V, Hurez V, Pandeswara SL, Sun L, Liu A, Hasty P, Sharp D, Curiel TJ. 60 Cytokine. 63: 257. DOI: 10.1016/J.Cyto.2013.06.063 |
0.362 |
|
| 2012 |
Kim TM, Ko JH, Hu L, Kim SA, Bishop AJ, Vijg J, Montagna C, Hasty P. RAD51 mutants cause replication defects and chromosomal instability. Molecular and Cellular Biology. 32: 3663-80. PMID 22778135 DOI: 10.1128/Mcb.00406-12 |
0.426 |
|
| 2012 |
Dollé M, Kuiper R, Roodbergen M, Robinson J, de Vlugt S, Wijnhoven S, Beems D, de la Fonteyne L, de With P, Niedernhofer L, Hasty P, Vijg J, Hoeijmakers J, van Steeg H. Ercc1 Deficient Mice Show Segmental Progeria Journal of Comparative Pathology. 146: 51. DOI: 10.1016/J.Jcpa.2011.11.025 |
0.333 |
|
| 2011 |
Dollé ME, Kuiper RV, Roodbergen M, Robinson J, de Vlugt S, Wijnhoven SW, Beems RB, de la Fonteyne L, de With P, van der Pluijm I, Niedernhofer LJ, Hasty P, Vijg J, Hoeijmakers JH, van Steeg H. Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiology of Aging & Age Related Diseases. 1. PMID 22953029 DOI: 10.3402/pba.v1i0.7219 |
0.312 |
|
| 2011 |
Dumitrache LC, Hu L, Son MY, Li H, Wesevich A, Scully R, Stark J, Hasty P. Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics. 188: 787-97. PMID 21546543 DOI: 10.1534/Genetics.111.129833 |
0.47 |
|
| 2011 |
Kim TM, Ko JH, Choi YJ, Hu L, Hasty P. The phenotype of FancB-mutant mouse embryonic stem cells. Mutation Research. 712: 20-7. PMID 21458466 DOI: 10.1016/J.Mrfmmm.2011.03.010 |
0.489 |
|
| 2011 |
Choi YJ, Son MY, Hasty P. One-step knockin for inducible expression in mouse embryonic stem cells. Genesis (New York, N.Y. : 2000). 49: 92-7. PMID 21344611 DOI: 10.1002/Dvg.20699 |
0.399 |
|
| 2010 |
Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA. Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 464: 1214-7. PMID 20383123 DOI: 10.1038/Nature08926 |
0.431 |
|
| 2010 |
Hasty P. Rapamycin: the cure for all that ails. Journal of Molecular Cell Biology. 2: 17-9. PMID 19805415 DOI: 10.1093/Jmcb/Mjp033 |
0.324 |
|
| 2009 |
Bennardo N, Gunn A, Cheng A, Hasty P, Stark JM. Limiting the persistence of a chromosome break diminishes its mutagenic potential. Plos Genetics. 5: e1000683. PMID 19834534 DOI: 10.1371/Journal.Pgen.1000683 |
0.423 |
|
| 2009 |
Holcomb VB, Vogel H, Hasty P. Unlike p53, p27 failed to exhibit an anti-tumor genetic interaction with Ku80. Cell Cycle (Georgetown, Tex.). 8: 2463-6. PMID 19597334 DOI: 10.4161/Cc.8.15.9249 |
0.773 |
|
| 2009 |
Li H, Choi YJ, Hanes MA, Marple T, Vogel H, Hasty P. Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells. Oncogene. 28: 1875-8. PMID 19330025 DOI: 10.1038/Onc.2009.57 |
0.52 |
|
| 2009 |
Dumitrache LC, Hu L, Hasty P. TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations. Mutation Research. 662: 84-7. PMID 19094998 DOI: 10.1016/J.Mrfmmm.2008.11.012 |
0.451 |
|
| 2009 |
Gurley KE, Moser R, Gu Y, Hasty P, Kemp CJ. DNA-PK suppresses a p53-independent apoptotic response to DNA damage. Embo Reports. 10: 87-93. PMID 19057578 DOI: 10.1038/Embor.2008.214 |
0.458 |
|
| 2008 |
Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P. Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Research. 68: 9497-502. PMID 19010925 DOI: 10.1158/0008-5472.Can-08-2085 |
0.768 |
|
| 2008 |
Busuttil RA, Muñoz DP, Garcia AM, Rodier F, Kim WH, Suh Y, Hasty P, Campisi J, Vijg J. Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. Plos One. 3: e3458. PMID 18941635 DOI: 10.1371/Journal.Pone.0003458 |
0.479 |
|
| 2008 |
Kim TM, Choi YJ, Ko JH, Hasty P. High-throughput knock-in coupling gene targeting with the HPRT minigene and Cre-mediated recombination. Genesis (New York, N.Y. : 2000). 46: 732-7. PMID 18932256 DOI: 10.1002/Dvg.20439 |
0.403 |
|
| 2008 |
Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, Hasty P, Hoeijmakers JH, Niedernhofer LJ. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Molecular and Cellular Biology. 28: 5082-92. PMID 18541667 DOI: 10.1128/Mcb.00293-08 |
0.502 |
|
| 2008 |
Hasty P. Is NHEJ a tumor suppressor or an aging suppressor? Cell Cycle (Georgetown, Tex.). 7: 1139-45. PMID 18418036 DOI: 10.4161/Cc.7.9.5807 |
0.5 |
|
| 2008 |
Li H, Mitchell JR, Hasty P. DNA double-strand breaks: a potential causative factor for mammalian aging? Mechanisms of Ageing and Development. 129: 416-24. PMID 18346777 DOI: 10.1016/J.Mad.2008.02.002 |
0.464 |
|
| 2008 |
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage Oncogene. 27: 3977-3985. PMID 18317453 DOI: 10.1038/Onc.2008.17 |
0.32 |
|
| 2008 |
van de Ven M, Andressoo J, Holcomb VB, von Lindern M, Jong WMC, Zeeuw CID, Suh Y, Hasty P, Hoeijmakers JHJ, van der Horst GTJ, Mitchell JR. Correction: Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice Plos Genetics. 4. DOI: 10.1371/annotation/31502636-9bdf-4cb1-b995-4a30a607e316 |
0.708 |
|
| 2007 |
Holcomb VB, Vogel H, Hasty P. Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs. Mechanisms of Ageing and Development. 128: 601-8. PMID 17928034 DOI: 10.1016/J.Mad.2007.08.006 |
0.781 |
|
| 2007 |
Chen MJ, Dumitrache LC, Wangsa D, Ma SM, Padilla-Nash H, Ried T, Hasty P. Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells. Cancer Research. 67: 9077-83. PMID 17909011 DOI: 10.1158/0008-5472.Can-07-1146 |
0.766 |
|
| 2007 |
Li H, Vogel H, Holcomb VB, Gu Y, Hasty P. Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Molecular and Cellular Biology. 27: 8205-14. PMID 17875923 DOI: 10.1128/Mcb.00785-07 |
0.773 |
|
| 2007 |
Holcomb VB, Kim TM, Dumitrache LC, Ma SM, Chen MJ, Hasty P. HPRT minigene generates chimeric transcripts as a by-product of gene targeting. Genesis (New York, N.Y. : 2000). 45: 275-81. PMID 17457929 DOI: 10.1002/Dvg.20300 |
0.691 |
|
| 2007 |
Chen MJ, Ma SM, Dumitrache LC, Hasty P. Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2. Nucleic Acids Research. 35: 2682-94. PMID 17426129 DOI: 10.1093/Nar/Gkm151 |
0.758 |
|
| 2007 |
van de Ven M, Andressoo JO, Holcomb VB, Hasty P, Suh Y, van Steeg H, Garinis GA, Hoeijmakers JH, Mitchell JR. Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mechanisms of Ageing and Development. 128: 58-63. PMID 17126380 DOI: 10.1016/J.Mad.2006.11.011 |
0.737 |
|
| 2006 |
van de Ven M, Andressoo JO, Holcomb VB, von Lindern M, Jong WM, De Zeeuw CI, Suh Y, Hasty P, Hoeijmakers JH, van der Horst GT, Mitchell JR. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. Plos Genetics. 2: e192. PMID 17173483 DOI: 10.1371/Journal.Pgen.0020192 |
0.757 |
|
| 2006 |
Marple T, Kim TM, Hasty P. Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination. Mutation Research. 602: 110-20. PMID 16997331 DOI: 10.1016/J.Mrfmmm.2006.08.005 |
0.428 |
|
| 2006 |
Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene. 25: 7159-65. PMID 16751807 DOI: 10.1038/Sj.Onc.1209704 |
0.783 |
|
| 2005 |
Vijg J, Hasty P. Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam. Aging Cell. 4: 331-3. PMID 16300486 DOI: 10.1111/J.1474-9726.2005.00179.X |
0.438 |
|
| 2005 |
Yaneva M, Li H, Marple T, Hasty P. Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. Nucleic Acids Research. 33: 5320-30. PMID 16177181 DOI: 10.1093/Nar/Gki821 |
0.462 |
|
| 2005 |
Ohbayashi F, Balamotis MA, Kishimoto A, Aizawa E, Diaz A, Hasty P, Graham FL, Caskey CT, Mitani K. Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 102: 13628-33. PMID 16174752 DOI: 10.1073/Pnas.0506598102 |
0.427 |
|
| 2005 |
Hasty P. The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice. Mechanisms of Ageing and Development. 126: 71-7. PMID 15610764 DOI: 10.1016/J.Mad.2004.09.036 |
0.493 |
|
| 2004 |
Marple T, Li H, Hasty P. A genotoxic screen: rapid analysis of cellular dose-response to a wide range of agents that either damage DNA or alter genome maintenance pathways. Mutation Research. 554: 253-66. PMID 15450423 DOI: 10.1016/J.Mrfmmm.2004.05.004 |
0.422 |
|
| 2004 |
Hasty P, Vijg J. Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'. Aging Cell. 3: 67-9. PMID 15038820 DOI: 10.1111/J.1474-9728.2004.00087.X |
0.346 |
|
| 2004 |
Hasty P, Vijg J. Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell. 3: 55-65. PMID 15038819 DOI: 10.1111/J.1474-9728.2004.00082.X |
0.4 |
|
| 2003 |
Donoho G, Hasty P. High-throughput inducible expression of transgenes at the Hprt gene in mouse embryonic stem cells. Biotechniques. 34: 462-4, 466, 468. PMID 12661151 DOI: 10.2144/03343Bm02 |
0.351 |
|
| 2003 |
Donoho G, Brenneman MA, Cui TX, Donoviel D, Vogel H, Goodwin EH, Chen DJ, Hasty P. Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes, Chromosomes & Cancer. 36: 317-31. PMID 12619154 DOI: 10.1002/Gcc.10148 |
0.483 |
|
| 2003 |
Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. Aging and genome maintenance: lessons from the mouse? Science (New York, N.Y.). 299: 1355-9. PMID 12610296 DOI: 10.1126/Science.1079161 |
0.374 |
|
| 2002 |
Hasty P, Vijg J. Aging. Genomic priorities in aging. Science (New York, N.Y.). 296: 1250-1. PMID 11951000 DOI: 10.1126/Science.1071808 |
0.398 |
|
| 2001 |
Hasty P. The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals. Mechanisms of Ageing and Development. 122: 1651-62. PMID 11557271 DOI: 10.1016/S0047-6374(01)00294-9 |
0.447 |
|
| 2000 |
Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Molecular and Cellular Biology. 20: 3772-80. PMID 10805721 DOI: 10.1128/Mcb.20.11.3772-3780.2000 |
0.47 |
|
| 2000 |
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 2668-73. PMID 10716994 DOI: 10.1073/Pnas.97.6.2668 |
0.459 |
|
| 1999 |
Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P. Deletion of Ku86 causes early onset of senescence in mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 10770-5. PMID 10485901 DOI: 10.1073/Pnas.96.19.10770 |
0.486 |
|
| 1999 |
Osipovich O, Duhe RJ, Hasty P, Durum SK, Muegge K. Defining functional domains of Ku80: DNA end binding and survival after radiation. Biochemical and Biophysical Research Communications. 261: 802-7. PMID 10441505 DOI: 10.1006/Bbrc.1999.1118 |
0.435 |
|
| 1999 |
Vivian JL, Klein WH, Hasty P. Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. Biotechniques. 27: 154-62. PMID 10407678 DOI: 10.2144/99271Rr04 |
0.343 |
|
| 1997 |
Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C, Sands A, Eichele G, Hasty P, Bradley A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature. 386: 804-10. PMID 9126738 DOI: 10.1038/386804A0 |
0.453 |
|
| 1997 |
Lu Q, Hasty P, Shur BD. Targeted mutation in β1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality Developmental Biology. 181: 257-267. PMID 9013935 DOI: 10.1006/Dbio.1996.8444 |
0.373 |
|
| 1997 |
Lim DS, Hasty P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Molecular and Cellular Biology. 16: 7133-43. PMID 8943369 DOI: 10.1128/Mcb.16.12.7133 |
0.432 |
|
| 1996 |
Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 86: 379-89. PMID 8756720 DOI: 10.1016/S0092-8674(00)80111-7 |
0.406 |
|
| 1995 |
Mitani K, Wakamiya M, Hasty P, Graham FL, Bradley A, Caskey CT. Gene targeting in mouse embryonic stem cells with an adenoviral vector. Somatic Cell and Molecular Genetics. 21: 221-31. PMID 8525428 DOI: 10.1007/Bf02255777 |
0.376 |
|
| 1995 |
Hasty P, Rivera-Pérez J, Bradley A. Gene conversion during vector insertion in embryonic stem cells. Nucleic Acids Research. 23: 2058-64. PMID 7596837 DOI: 10.1093/Nar/23.11.2058 |
0.373 |
|
| 1995 |
Hasty P, O'Neal WK, Liu KQ, Morris AP, Bebok Z, Shumyatsky GB, Jilling T, Sorscher EJ, Bradley A, Beaudet AL. Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene. Somatic Cell and Molecular Genetics. 21: 177-87. PMID 7482032 DOI: 10.1007/Bf02254769 |
0.419 |
|
| 1994 |
Zhang H, Hasty P, Bradley A. Targeting frequency for deletion vectors in embryonic stem cells. Molecular and Cellular Biology. 14: 2404-10. PMID 8139544 DOI: 10.1128/Mcb.14.4.2404 |
0.366 |
|
| 1994 |
Hasty P, Crist M, Grompe M, Bradley A. Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci. Molecular and Cellular Biology. 14: 8385-90. PMID 7969173 DOI: 10.1128/Mcb.14.12.8385 |
0.306 |
|
| 1993 |
Rudolph U, Brabet P, Kaplan J, Hasty P, Bradley A, Birnbaumer L. Targeting of the Gi2 alpha gene in ES cells with replacement and insertion vectors. Journal of Receptor Research. 13: 619-37. PMID 8450507 DOI: 10.3109/10799899309073683 |
0.321 |
|
| 1993 |
Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 364: 501-6. PMID 8393145 DOI: 10.1038/364501A0 |
0.378 |
|
| 1993 |
Rudolph U, Brabet P, Hasty P, Bradley A, Birnbaumer L. Disruption of the G(i2) alpha locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair. Transgenic Research. 2: 345-55. PMID 8268981 DOI: 10.1007/Bf01976176 |
0.384 |
|
| 1993 |
O'Neal WK, Hasty P, McCray PB, Casey B, Rivera-Pérez J, Welsh MJ, Beaudet AL, Bradley A. A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Human Molecular Genetics. 2: 1561-9. PMID 7505691 DOI: 10.1093/Hmg/2.10.1561 |
0.405 |
|
| 1992 |
Hasty P, Rivera-Pérez J, Bradley A. The role and fate of DNA ends for homologous recombination in embryonic stem cells. Molecular and Cellular Biology. 12: 2464-74. PMID 1588950 DOI: 10.1128/Mcb.12.6.2464 |
0.425 |
|
| 1992 |
Bradley A, Hasty P, Davis A, Ramirez-Solis R. Modifying the mouse: design and desire. Bio/Technology (Nature Publishing Company). 10: 534-9. PMID 1368233 DOI: 10.1038/Nbt0592-534 |
0.4 |
|
| 1991 |
Zheng H, Hasty P, Brenneman MA, Grompe M, Gibbs RA, Wilson JH, Bradley A. Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 8067-71. PMID 1896453 DOI: 10.1073/Pnas.88.18.8067 |
0.407 |
|
| 1991 |
Hasty P, Rivera-Pérez J, Chang C, Bradley A. Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Molecular and Cellular Biology. 11: 4509-17. PMID 1875936 DOI: 10.1128/Mcb.11.9.4509 |
0.377 |
|
| 1991 |
Hasty P, Ramírez-Solis R, Krumlauf R, Bradley A. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells Nature. 350: 243-246. PMID 1672446 DOI: 10.1038/350243A0 |
0.389 |
|
| 1991 |
Hasty P, Rivera-Pérez J, Bradley A. The length of homology required for gene targeting in embryonic stem cells. Molecular and Cellular Biology. 11: 5586-91. PMID 1656234 DOI: 10.1128/Mcb.11.11.5586 |
0.355 |
|
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