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Zena Werb - Publications

Affiliations: 
Anatomy University of California, San Francisco, San Francisco, CA 
Area:
role of the cellular microenvironment and intercellular communication in breast development and cancer
Website:
http://werblab.ucsf.edu/node/3179
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330 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Winkler J, Tan W, Diadhiou CM, McGinnis CS, Abbasi A, Hasnain S, Durney S, Atamaniuc E, Superville D, Awni L, Lee JV, Hinrichs JH, Wagner PS, Singh N, Hein MY, ... ... Werb Z, et al. Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes. The Journal of Clinical Investigation. 134. PMID 39225101 DOI: 10.1172/JCI164227  0.314
2021 Metcalf KJ, Alazzeh A, Werb Z, Weaver VM. Leveraging microenvironmental synthetic lethalities to treat cancer. The Journal of Clinical Investigation. 131. PMID 33720045 DOI: 10.1172/JCI143765  0.535
2020 Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, ... ... Werb Z, et al. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. Nature Materials. PMID 33257795 DOI: 10.1038/s41563-020-00849-5  0.691
2020 Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. Bmc Cancer. 20: 542. PMID 32522170 DOI: 10.1186/S12885-020-06986-Z  0.347
2020 Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, ... ... Werb Z, et al. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nature Cell Biology. 22: 310-320. PMID 32144411 DOI: 10.1038/S41556-020-0477-0  0.377
2020 Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Developmental Cell. PMID 32084360 DOI: 10.1016/J.Devcel.2020.01.025  0.423
2020 Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, ... ... Werb Z, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews. Cancer. PMID 31980749 DOI: 10.1038/S41568-019-0238-1  0.789
2020 Werb Z, Gonzalez H, Winkler J, Berens E. Abstract IA06: The tissue-specific microenvironment in primary tumors and metastases Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Ia06  0.457
2020 Winkler J, Tan W, McGinnis C, Gartner Z, Darmanis S, Werb Z. Abstract 351: Alterations in immune cell signatures during breast cancer metastasis at single cell resolution Cancer Research. 80: 351-351. DOI: 10.1158/1538-7445.Am2020-351  0.425
2019 Owyong M, Chou J, van den Bijgaart RJ, Kong N, Efe G, Maynard C, Talmi-Frank D, Solomonov I, Koopman C, Hadler-Olsen E, Headley M, Lin C, Wang CY, Sagi I, Werb Z, et al. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. Life Science Alliance. 2. PMID 31727800 DOI: 10.26508/lsa.201800226  0.588
2019 Hagerling C, Gonzalez H, Salari K, Wang CY, Lin C, Robles I, van Gogh M, Dejmek A, Jirström K, Werb Z. Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591235 DOI: 10.1073/Pnas.1907660116  0.375
2019 McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nature Methods. PMID 31209384 DOI: 10.1038/S41592-019-0433-8  0.345
2018 Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z. Tumour heterogeneity and metastasis at single-cell resolution. Nature Cell Biology. 20: 1349-1360. PMID 30482943 DOI: 10.1038/S41556-018-0236-7  0.345
2018 Medler TR, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin M, Margolin AA, Werb Z, Coussens LM. Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. Cancer Cell. 34: 561-578.e6. PMID 30300579 DOI: 10.1016/J.Ccell.2018.09.003  0.575
2018 Gonzalez H, Hagerling C, Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes & Development. 32: 1267-1284. PMID 30275043 DOI: 10.1101/Gad.314617.118  0.379
2018 Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, ... Werb Z, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nature Communications. 9: 2028. PMID 29795293 DOI: 10.1038/S41467-018-04334-1  0.379
2018 Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 9: 10945-10961. PMID 29541388 DOI: 10.18632/Oncotarget.23760  0.401
2018 Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & Development. PMID 29483153 DOI: 10.1101/Gad.301366.117  0.781
2018 Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29339479 DOI: 10.1073/Pnas.1718009115  0.599
2018 Drain AP, Takai K, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Abstract LB-055: Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-055  0.781
2018 Camarda R, Williams J, Malkov S, Zimmerman LJ, Manning S, Aran D, Beardsley A, Mark DVd, Haren Jv, Chen Y, Berdan C, Louie S, Mahieu C, Winkler J, Willey E, ... ... Werb Z, et al. Abstract 2398: Tumor cell-adipocyte gap junctions activate lipolysis in breast cancer Cancer Research. 78: 2398-2398. DOI: 10.1158/1538-7445.Am2018-2398  0.408
2017 Gonzalez H, Robles I, Werb Z. Innate and Acquired Immune Surveillance in the Post-Dissemination Phase of Metastasis. The Febs Journal. PMID 29131550 DOI: 10.1111/Febs.14325  0.39
2017 Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, et al. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Translational Stroke Research. PMID 28900857 DOI: 10.1007/S12975-017-0560-4  0.334
2017 Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Veloso H, Ruderisch A, Yu Y, Lai MD, Werb Z. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. PMID 28581515 DOI: 10.1038/Onc.2017.165  0.633
2017 Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270600 DOI: 10.1073/Pnas.1701464114  0.365
2017 Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28258171 DOI: 10.1073/Pnas.1701690114  0.394
2017 Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. Molecular and Clinical Oncology. 6: 7-18. PMID 28123722 DOI: 10.3892/Mco.2016.1094  0.362
2016 Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, ... ... Werb Z, et al. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nature Medicine. PMID 27775705 DOI: 10.1038/Nm.4213  0.397
2016 Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. PMID 27756881 DOI: 10.18632/Oncotarget.12658  0.601
2016 Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K. Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. Nature Communications. 7: 13050. PMID 27725631 DOI: 10.1038/Ncomms13050  0.394
2016 Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621461 DOI: 10.1073/Pnas.1611532113  0.34
2016 Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Experimental Neurology. PMID 27468657 DOI: 10.1016/J.Expneurol.2016.07.018  0.351
2016 Chou J, Chan MF, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiology Spectrum. 4. PMID 27227311 DOI: 10.1128/Microbiolspec.Mchd-0002-2015  0.624
2016 Hagerling C, Werb Z. Neutrophils: Critical components in experimental animal models of cancer. Seminars in Immunology. PMID 26976824 DOI: 10.1016/J.Smim.2016.02.003  0.38
2016 Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903627 DOI: 10.1073/Pnas.1600645113  0.303
2016 Devignes C, Duchamp dLO, Gonon A, Devillers A, Yu Y, Werb Z, Provot S. Hif1alpha leads to chondrodysplasia in MMP-deficient mice Bone Abstracts. DOI: 10.1530/Boneabs.5.Op29  0.34
2016 Lawson D, Kessenbrock K, Werb Z. Abstract IA24: A stem cell program in early human metastatic breast cancer cells Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-Ia24  0.443
2016 Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Camarda R, Anderton BN, Bazarov AV, Eyob H, Rohrberg J, Yaswen P, McManus MT, Rugo HS, ... Werb Z, et al. Abstract B34: PIM kinase as a novel therapeutic target for triple-negative breast cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-B34  0.42
2016 Devignes C, Brenot A, Devillers A, Fabre S, Aslan Y, Schepers K, Chou J, Casbon A, Werb Z, Provot S. La signalisation HIF dans les ostéoprogéniteurs stimule la croissance et la dissémination des tumeurs mammaires Revue Du Rhumatisme. 83: A103-A104. DOI: 10.1016/S1169-8330(16)30363-5  0.461
2015 Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(✩). Biotechnology Reports (Amsterdam, Netherlands). 7: 157-165. PMID 26989654 DOI: 10.1016/J.Btre.2015.07.001  0.308
2015 Lawson DA, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harbor Protocols. 2015: pdb.prot078071. PMID 26631119 DOI: 10.1101/Pdb.Prot078071  0.368
2015 Kim M, Shewan A, Ewald AJ, Werb Z, Mostov KE. P114RhoGEF governs cell motility and lumen formation during tubulogenesis via ROCK-myosin II pathway. Journal of Cell Science. PMID 26483385 DOI: 10.1242/Jcs.172361  0.342
2015 Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. PMID 26416748 DOI: 10.1038/Nature15260  0.437
2015 Werb Z, Lu P. The Role of Stroma in Tumor Development. Cancer Journal (Sudbury, Mass.). 21: 250-3. PMID 26222075 DOI: 10.1097/Ppo.0000000000000127  0.411
2015 Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 4: e1008871. PMID 26155427 DOI: 10.1080/2162402X.2015.1008871  0.386
2015 Chambers AF, Werb Z. Invasion and metastasis--recent advances and future challenges. Journal of Molecular Medicine (Berlin, Germany). 93: 361-8. PMID 25772709 DOI: 10.1007/S00109-015-1269-Z  0.374
2015 Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 16: 225-38. PMID 25748930 DOI: 10.1016/J.Stem.2015.02.015  0.387
2015 Kessenbrock K, Wang CY, Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biology : Journal of the International Society For Matrix Biology. 44: 184-190. PMID 25661772 DOI: 10.1016/J.Matbio.2015.01.022  0.422
2015 Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 112: E566-75. PMID 25624500 DOI: 10.1073/Pnas.1424927112  0.44
2015 Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. The Journal of Biological Chemistry. 290: 3803-13. PMID 25538248 DOI: 10.1074/Jbc.M114.611202  0.645
2015 Hagerling C, Casbon AJ, Werb Z. Balancing the innate immune system in tumor development. Trends in Cell Biology. 25: 214-20. PMID 25444276 DOI: 10.1016/J.Tcb.2014.11.001  0.352
2015 Casbon A, Plaks V, Werb Z. Abstract IA09: Building the metastatic microenvironment Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-Ia09  0.441
2015 Plaks V, Chou J, Maynard C, Nguyen NH, Kong N, Solomonov I, Talmi-Frank D, Bonnans C, Sagi I, Werb Z. Abstract 4724: Targeting matrix metalloproteinases (MMP) for anti-metastatic therapy: Blocking active MMP9 abrogates metastatic niche formation and prevents metastatic seeding in a breast cancer model Cancer Research. 75: 4724-4724. DOI: 10.1158/1538-7445.Am2015-4724  0.645
2014 Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nature Reviews. Molecular Cell Biology. 15: 786-801. PMID 25415508 DOI: 10.1038/Nrm3904  0.609
2014 Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proceedings of the National Academy of Sciences of the United States of America. 111: E5086-95. PMID 25385645 DOI: 10.1073/Pnas.1419899111  0.423
2014 Bonnans C, Lohela M, Werb Z. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. Journal of Visualized Experiments : Jove. e51916. PMID 25350573 DOI: 10.3791/51916  0.362
2014 Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Developmental Cell. 31: 171-87. PMID 25307480 DOI: 10.1016/J.Devcel.2014.08.027  0.32
2014 Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 2078-92. PMID 25017248 DOI: 10.1158/1055-9965.Epi-14-0403  0.3
2014 Horiuchi D, Zhou AY, Corella AN, Yau C, Lawson DA, Bazarov AV, Yaswen P, McManus MT, Werb Z, Welm AL, Goga A. Abstract LB-122: PIM1 kinase inhibition halts the growth of MYC-overexpressing triple-negative breast tumors Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-122  0.43
2014 Shahi P, Slorach EM, Chou J, Lawson D, Yu Y, Werb Z. Abstract 2475: Zpo2 promotes aggressive breast cancer development through downregulation of GATA3 Cancer Research. 74: 2475-2475. DOI: 10.1158/1538-7445.Am2014-2475  0.63
2013 Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 155: 1639-51. PMID 24332913 DOI: 10.1016/J.Cell.2013.11.029  0.423
2013 Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle (Georgetown, Tex.). 12: 3262-71. PMID 24036551 DOI: 10.4161/Cc.26087  0.588
2013 Plaks V, Koopman CD, Werb Z. Cancer. Circulating tumor cells. Science (New York, N.Y.). 341: 1186-8. PMID 24031008 DOI: 10.1126/Science.1235226  0.396
2013 Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 13: 300-13. PMID 23871604 DOI: 10.1016/J.Stem.2013.06.005  0.713
2013 Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. Journal of Cell Science. 126: 3948-60. PMID 23813962 DOI: 10.1242/Jcs.128033  0.399
2013 Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proceedings of the National Academy of Sciences of the United States of America. 110: 11109-14. PMID 23776237 DOI: 10.1073/Pnas.1309561110  0.35
2013 Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nature Cell Biology. 15: 201-13. PMID 23354167 DOI: 10.1038/Ncb2672  0.576
2013 Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Reports. 3: 70-8. PMID 23352663 DOI: 10.1016/J.Celrep.2012.12.017  0.384
2013 Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 52: 111-9. PMID 23010105 DOI: 10.1016/J.Bone.2012.09.018  0.4
2013 Casbon AJ, Lohela M, Plaks V, Werb Z. Abstract IA24: How tumors regulate their microenvironment in primary sites and metastasis Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-Ia24  0.403
2013 Provot S, Brenot A, Casbon A, Yu Y, Werb Z. Abstract IA2: Microenvironmental control of bone metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-Ia2  0.367
2013 Werb Z. Abstract IA26: Regulation of metastasis in breast cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia26  0.414
2013 Horiuchi D, Zhou AY, Corella AN, Yau C, Lawson DA, Bazarov AV, Yaswen P, McManus MT, Welm AL, Werb Z, Goga A. Abstract B232: PIM1 kinase is essential for the growth of MYC-overexpressing triple-negative breast tumors and is an efficacious therapeutic target. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B232  0.393
2012 Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discovery. 2: 1078-80. PMID 23230184 DOI: 10.1158/2159-8290.Cd-12-0465  0.554
2012 Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proceedings of the National Academy of Sciences of the United States of America. 109: E2595-604. PMID 22923691 DOI: 10.1073/Pnas.1212834109  0.47
2012 Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, ... ... Werb Z, et al. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discovery. 2: 638-51. PMID 22728437 DOI: 10.1158/2159-8290.Cd-12-0093  0.794
2012 Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, et al. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 21: 488-503. PMID 22516258 DOI: 10.1016/J.Ccr.2012.02.017  0.67
2012 Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 21: 402-17. PMID 22439936 DOI: 10.1016/J.Ccr.2012.01.008  0.672
2012 Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. The Journal of Cell Biology. 196: 395-406. PMID 22351925 DOI: 10.1083/Jcb.201102147  0.624
2012 Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. Journal of Cell Science. 125: 2638-54. PMID 22344263 DOI: 10.1242/jcs.096875  0.38
2012 Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proceedings of the National Academy of Sciences of the United States of America. 109: E388-97. PMID 22308451 DOI: 10.1073/Pnas.1120421109  0.388
2012 Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. The Journal of Clinical Investigation. 122: 911-22. PMID 22293178 DOI: 10.1172/Jci58215  0.377
2012 Park J, Rasch MG, Qiu J, Lund IK, Werb Z, Egeblad M. Abstract 2465: Matrix metalloproteinase 9 promotes breast cancer through regulation of insulin-like growth factor-binding proteins Cancer Research. 72: 2465-2465. DOI: 10.1158/1538-7445.Am2012-2465  0.441
2011 Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15894-903. PMID 22049432 DOI: 10.1523/Jneurosci.3943-11.2011  0.37
2011 Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21917992 DOI: 10.1101/Cshperspect.A005058  0.611
2011 Lin L, Bankaitis E, Heimbach L, Li N, Abrink M, Pejler G, An L, Diaz LA, Werb Z, Liu Z. Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. The Journal of Biological Chemistry. 286: 37358-67. PMID 21880713 DOI: 10.1074/Jbc.M111.272401  0.41
2011 Hong JS, Greenlee KJ, Pitchumani R, Lee SH, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. Journal of Immunology (Baltimore, Md. : 1950). 186: 6427-36. PMID 21508260 DOI: 10.4049/Jimmunol.1003449  0.34
2011 Kessenbrock K, Brown M, Werb Z. Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit14.24. PMID 21462166 DOI: 10.1002/0471142735.Im1424S93  0.405
2011 Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes & Development. 25: 471-84. PMID 21317240 DOI: 10.1101/Gad.1998111  0.632
2011 Ewald AJ, Werb Z, Egeblad M. Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harbor Protocols. 2011: pdb.top97. PMID 21285277 DOI: 10.1101/Pdb.Top97  0.656
2011 Ewald AJ, Werb Z, Egeblad M. Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harbor Protocols. 2011: pdb.prot5563. PMID 21285263 DOI: 10.1101/Pdb.Prot5563  0.592
2011 Ewald AJ, Werb Z, Egeblad M. Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harbor Protocols. 2011: pdb.prot5562. PMID 21285262 DOI: 10.1101/Pdb.Prot5562  0.601
2011 Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Disease Models & Mechanisms. 4: 203-11. PMID 21135056 DOI: 10.1242/Dmm.006304  0.362
2011 Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harbor Perspectives in Biology. 3. PMID 21106646 DOI: 10.1101/Cshperspect.A004333  0.349
2011 Werb Z. Abstract IA11: New insights into the microenvironment and metastasis Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Ia11  0.436
2011 Werb Z. A sticky wicket: Opposing functions of p120-catenin in development and cancer Developmental Cell. 20: e3. DOI: 10.1016/J.Devcel.2011.05.006  0.349
2010 Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 21795-800. PMID 21098272 DOI: 10.1073/Pnas.1016485107  0.344
2010 Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Developmental Cell. 18: 884-901. PMID 20627072 DOI: 10.1016/J.Devcel.2010.05.012  0.688
2010 Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 16: 156-70. PMID 20400713 DOI: 10.1177/1073858409355830  0.354
2010 Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 141: 52-67. PMID 20371345 DOI: 10.1016/J.Cell.2010.03.015  0.458
2010 Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, et al. Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease Models & Mechanisms. 3: 317-32. PMID 20223936 DOI: 10.1242/Dmm.003863  0.749
2010 Littlepage LE, Sternlicht MD, Rougier N, Phillips J, Gallo E, Yu Y, Williams K, Brenot A, Gordon JI, Werb Z. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Research. 70: 2224-34. PMID 20215503 DOI: 10.1158/0008-5472.Can-09-3515  0.717
2010 Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Disease Models & Mechanisms. 3: 224-35. PMID 20142327 DOI: 10.1242/Dmm.004226  0.358
2010 Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, ... Werb Z, et al. Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood. 115: 4302-12. PMID 20110420 DOI: 10.1182/Blood-2009-08-236851  0.385
2010 Lohela M, Werb Z. Intravital imaging of stromal cell dynamics in tumors. Current Opinion in Genetics & Development. 20: 72-8. PMID 19942428 DOI: 10.1016/J.Gde.2009.10.011  0.402
2010 Lederle W, Hartenstein B, Meides A, Kunzelmann H, Werb Z, Angel P, Mueller MM. MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis. 31: 1175-84. PMID 19892798 DOI: 10.1093/Carcin/Bgp248  0.395
2010 Lilla JN, Werb Z. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Developmental Biology. 337: 124-33. PMID 19850030 DOI: 10.1016/J.Ydbio.2009.10.021  0.808
2010 Chou J, Provot S, Werb Z. GATA3 in development and cancer differentiation: cells GATA have it! Journal of Cellular Physiology. 222: 42-9. PMID 19798694 DOI: 10.1002/Jcp.21943  0.63
2009 Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Mapping mammary gland architecture using multi-scale in situ analysis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 80-9. PMID 20023794 DOI: 10.1039/B816933K  0.363
2009 Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis and Rheumatism. 60: 3723-33. PMID 19950295 DOI: 10.1002/Art.25002  0.345
2009 Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. The Journal of Clinical Investigation. 119: 3713-22. PMID 19884654 DOI: 10.1172/Jci40053  0.359
2009 Bengatta S, Arnould C, Letavernier E, Monge M, de Préneuf HM, Werb Z, Ronco P, Lelongt B. MMP9 and SCF protect from apoptosis in acute kidney injury. Journal of the American Society of Nephrology : Jasn. 20: 787-97. PMID 19329763 DOI: 10.1681/Asn.2008050515  0.372
2009 Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. The Journal of Biological Chemistry. 284: 13792-803. PMID 19297327 DOI: 10.1074/Jbc.M900508200  0.794
2008 Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13467-77. PMID 19074020 DOI: 10.1523/Jneurosci.2287-08.2008  0.365
2008 Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Disease Models & Mechanisms. 1: 155-67; discussion 1. PMID 19048079 DOI: 10.1242/Dmm.000596  0.688
2008 Nielsen BS, Egeblad M, Rank F, Askautrud HA, Pennington CJ, Pedersen TX, Christensen IJ, Edwards DR, Werb Z, Lund LR. Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression. Plos One. 3: e2959. PMID 18698413 DOI: 10.1371/Journal.Pone.0002959  0.697
2008 Lu P, Ewald AJ, Martin GR, Werb Z. Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Developmental Biology. 321: 77-87. PMID 18585375 DOI: 10.1016/J.Ydbio.2008.06.005  0.415
2008 Ewald AJ, Brenot A, Duong M, Chan BS, Werb Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental Cell. 14: 570-81. PMID 18410732 DOI: 10.1016/J.Devcel.2008.03.003  0.374
2008 Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2: 90-102. PMID 18371425 DOI: 10.1016/J.Stem.2007.10.002  0.383
2008 Lu P, Yu Y, Perdue Y, Werb Z. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development (Cambridge, England). 135: 1395-405. PMID 18359901 DOI: 10.1242/Dev.018945  0.325
2008 Kouros-Mehr H, Kim JW, Bechis SK, Werb Z. GATA-3 and the regulation of the mammary luminal cell fate. Current Opinion in Cell Biology. 20: 164-70. PMID 18358709 DOI: 10.1016/J.Ceb.2008.02.003  0.773
2008 Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 13: 206-20. PMID 18328425 DOI: 10.1016/J.Ccr.2008.01.034  0.399
2008 Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 13: 141-52. PMID 18242514 DOI: 10.1016/J.Ccr.2008.01.011  0.794
2008 Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY. CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Research. 68: 506-15. PMID 18199546 DOI: 10.1158/0008-5472.Can-07-3060  0.691
2008 Ewald AJ, Brenot A, Werb Z. Molecular regulation of collective epithelial migration during mammary branching morphogenesis Developmental Biology. 319: 478. DOI: 10.1016/J.Ydbio.2008.05.046  0.322
2008 Littlepage LE, Egeblad M, Werb Z. The Tumor Microenvironment in Cancer Progression The Molecular Basis of Cancer. 229-239. DOI: 10.1016/B978-141603703-3.10017-2  0.663
2007 Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K. The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell Stem Cell. 1: 658-70. PMID 18371407 DOI: 10.1016/J.Stem.2007.10.012  0.373
2007 Sneddon JB, Werb Z. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 1: 607-11. PMID 18371402 DOI: 10.1016/J.Stem.2007.11.009  0.364
2007 Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. A model of intussusceptive angiogenesis. Novartis Foundation Symposium. 283: 37-42; discussion 42. PMID 18300412 DOI: 10.1002/9780470319413.Ch4  0.308
2007 Melani C, Sangaletti S, Barazzetta FM, Werb Z, Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Research. 67: 11438-46. PMID 18056472 DOI: 10.1158/0008-5472.Can-07-1882  0.429
2007 Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. Plos One. 2: e1150. PMID 17987127 DOI: 10.1371/Journal.Pone.0001150  0.349
2007 Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Developmental Cell. 13: 462-3. PMID 17925222 DOI: 10.1016/J.Devcel.2007.09.013  0.604
2007 Fata JE, Mori H, Ewald AJ, Zhang H, Yao E, Werb Z, Bissell MJ. The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Developmental Biology. 306: 193-207. PMID 17448457 DOI: 10.1016/J.Ydbio.2007.03.013  0.357
2007 Egeblad M, Shen HC, Behonick DJ, Wilmes L, Eichten A, Korets LV, Kheradmand F, Werb Z, Coussens LM. Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 1683-93. PMID 17440987 DOI: 10.1002/Dvdy.21159  0.726
2007 Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2580-91. PMID 17392479 DOI: 10.1096/Fj.06-7860Com  0.385
2007 Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Molecular Biology of the Cell. 18: 1693-700. PMID 17332496 DOI: 10.1091/Mbc.E06-11-1052  0.362
2007 Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nature Reviews. Molecular Cell Biology. 8: 221-33. PMID 17318226 DOI: 10.1038/Nrm2125  0.406
2007 Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. Journal of Mammary Gland Biology and Neoplasia. 12: 37-45. PMID 17286210 DOI: 10.1007/S10911-007-9036-6  0.346
2007 Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiological Reviews. 87: 69-98. PMID 17237343 DOI: 10.1152/Physrev.00022.2006  0.381
2007 Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Molecular and Cellular Biology. 27: 678-88. PMID 17116694 DOI: 10.1128/Mcb.01279-06  0.33
2007 Hattori K, Akiyama H, Lund LR, Werb Z, Heissig B. Novel Functions for a Fibrinolytic Pathway in Controlling Hematopoiesis. Blood. 110: 86-86. DOI: 10.1182/Blood.V110.11.86.86  0.454
2006 Yeh MW, Rougier JP, Park JW, Duh QY, Wong M, Werb Z, Clark OH. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocrine-Related Cancer. 13: 1173-83. PMID 17158762 DOI: 10.1677/Erc.1.01226  0.414
2006 Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 127: 1041-55. PMID 17129787 DOI: 10.1016/J.Cell.2006.09.048  0.764
2006 Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 2107-14. PMID 17119035 DOI: 10.1158/1055-9965.Epi-06-0351  0.374
2006 Greenlee KJ, Corry DB, Engler DA, Matsunami RK, Tessier P, Cook RG, Werb Z, Kheradmand F. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. Journal of Immunology (Baltimore, Md. : 1950). 177: 7312-21. PMID 17082650 DOI: 10.4049/Jimmunol.177.10.7312  0.379
2006 Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 235: 3404-12. PMID 17039550 DOI: 10.1002/Dvdy.20978  0.721
2006 Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9841-50. PMID 17005848 DOI: 10.1523/Jneurosci.1993-06.2006  0.322
2006 Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z. Hormonal and local control of mammary branching morphogenesis. Differentiation; Research in Biological Diversity. 74: 365-81. PMID 16916375 DOI: 10.1111/J.1432-0436.2006.00105.X  0.713
2006 Chaillan FA, Rivera S, Marchetti E, Jourquin J, Werb Z, Soloway PD, Khrestchatisky M, Roman FS. Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behavioural Brain Research. 173: 191-8. PMID 16860884 DOI: 10.1016/J.Bbr.2006.06.020  0.333
2006 Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. The Embo Journal. 25: 2686-97. PMID 16763560 DOI: 10.1038/Sj.Emboj.7601173  0.778
2006 Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, ... ... Werb Z, et al. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nature Medicine. 12: 557-67. PMID 16648859 DOI: 10.1038/Nm1400  0.355
2006 Zeisberg M, Khurana M, Rao VH, Cosgrove D, Rougier JP, Werner MC, Shield CF, Werb Z, Kalluri R. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. Plos Medicine. 3: e100. PMID 16509766 DOI: 10.1371/Journal.Pmed.0030100  0.359
2006 Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. Bmc Biochemistry. 7: 2. PMID 16417632 DOI: 10.1186/1471-2091-7-2  0.331
2006 Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. The Journal of Investigative Dermatology. 126: 486-96. PMID 16374453 DOI: 10.1038/Sj.Jid.5700084  0.367
2006 Akiyama H, Lund LR, Morita Y, Nakauchi H, Ogawa H, Okumura K, Dano K, Werb Z, Heissig B, Hattori K. Novel Functions for a Fibrinolytic Pathway in Controlling the Stem Cell Niche. Blood. 108: 1394-1394. DOI: 10.1182/Blood.V108.11.1394.1394  0.42
2005 Egeblad M, Littlepage LE, Werb Z. The fibroblastic coconspirator in cancer progression. Cold Spring Harbor Symposia On Quantitative Biology. 70: 383-8. PMID 16869775 DOI: 10.1101/Sqb.2005.70.007  0.732
2005 Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia (New York, N.Y.). 7: 1001-10. PMID 16331886 DOI: 10.1593/Neo.05496  0.684
2005 Stickens D, Zak BM, Rougler N, Esko JD, Werb Z. Mice deficient in Ext2 lack heparan sulfate and develop exostoses Development. 132: 5055-5068. PMID 16236767 DOI: 10.1242/Dev.02088  0.322
2005 Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Molecular Biology of the Cell. 16: 5528-37. PMID 16195353 DOI: 10.1091/Mbc.E05-02-0128  0.401
2005 Wall SJ, Werner E, Werb Z, DeClerck YA. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen Journal of Biological Chemistry. 280: 40187-40194. PMID 16186104 DOI: 10.1074/Jbc.M508226200  0.41
2005 Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K. Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization Journal of Experimental Medicine. 202: 739-750. PMID 16157686 DOI: 10.1084/Jem.20050959  0.404
2005 Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival Nature Cell Biology. 7: 870-879. PMID 16113679 DOI: 10.1038/Ncb1288  0.332
2005 Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, Werb Z. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (Cambridge, England). 132: 3923-33. PMID 16079154 DOI: 10.1242/Dev.01966  0.744
2005 Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K. A role for niches in hematopoietic cell development Hematology. 10: 247-253. PMID 16019473 DOI: 10.1080/10245330500067249  0.324
2005 Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436: 123-7. PMID 16001073 DOI: 10.1038/Nature03688  0.727
2005 Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 9884-9. PMID 15994223 DOI: 10.1073/Pnas.0504391102  0.306
2005 Littlepage LE, Egeblad M, Werb Z. Coevolution of cancer and stromal cellular responses. Cancer Cell. 7: 499-500. PMID 15950897 DOI: 10.1016/J.Ccr.2005.05.019  0.783
2005 Liu Z, Li N, Diaz LA, Shipley M, Senior RM, Werb Z. Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. The Journal of Clinical Investigation. 115: 879-87. PMID 15841177 DOI: 10.1172/Jci23977  0.375
2005 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z. Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Molecular Biology of the Cell. 16: 3028-39. PMID 15800063 DOI: 10.1091/Mbc.E04-12-1119  0.387
2005 Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 54: 694-701. PMID 15734845 DOI: 10.2337/Diabetes.54.3.694  0.41
2005 Lee MM, Yoon BJ, Osiewicz K, Preston M, Bundy B, Van Heeckeren AM, Werb Z, Soloway PD. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection Infection and Immunity. 73: 661-665. PMID 15618213 DOI: 10.1128/Iai.73.1.661-665.2005  0.347
2005 Masson V, de la Ballina LR, Munaut C, Wielockx B, Jost M, Maillard C, Blacher S, Bajou K, Itoh T, Itohara S, Werb Z, Libert C, Foidart JM, Noël A. Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 234-6. PMID 15550552 DOI: 10.1096/Fj.04-2140Fje  0.389
2004 Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice Development. 131: 5883-5895. PMID 15539485 DOI: 10.1242/Dev.01461  0.367
2004 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. The Journal of Biological Chemistry. 279: 53848-56. PMID 15456762 DOI: 10.1074/Jbc.M403114200  0.341
2004 Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases Current Opinion in Cell Biology. 16: 558-564. PMID 15363807 DOI: 10.1016/J.Ceb.2004.07.010  0.369
2004 Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues Development. 131: 3047-3055. PMID 15163627 DOI: 10.1242/Dev.01158  0.359
2004 Ortega N, Behonick DJ, Werb Z. Matrix remodeling during endochondral ossification Trends in Cell Biology. 14: 86-93. PMID 15102440 DOI: 10.1016/J.Tcb.2003.12.003  0.38
2004 Corry DB, Kiss A, Song LZ, Song L, Xu J, Lee SH, Werb Z, Kheradmand F. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines Faseb Journal. 18: 995-997. PMID 15059974 DOI: 10.1096/Fj.03-1412Fje  0.381
2004 Chantrain CF, Shimada H, Jodele S, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment Cancer Research. 64: 1675-1686. PMID 14996727 DOI: 10.1158/0008-5472.Can-03-0160  0.637
2004 Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes Breast Cancer Research. 6: 1-11. PMID 14680479 DOI: 10.1186/Bcr634  0.448
2004 Hattori K, Ohki Y, Sato Y, Rafii S, Werb Z, Heissig B. Low-Dose Irradiation Promotes Tissue Revascularization through Matrix Metalloproteinase-9 Mediated VEGF Release from Mast Cells. Blood. 104: 648-648. DOI: 10.1182/Blood.V104.11.648.648  0.419
2004 Werb Z, Evan G. Oncogenes and cell proliferation: Maintenance of genome integrity, tumor stem cells, and the somatic microenvironment Current Opinion in Genetics and Development. 14: 1-3. DOI: 10.1016/J.Gde.2003.12.004  0.356
2003 Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 15853-8. PMID 14668450 DOI: 10.1073/Pnas.2136825100  0.703
2003 Behonick DJ, Werb Z. A bit of give and take: The relationship between the extracellular matrix and the developing chondrocyte Mechanisms of Development. 120: 1327-1336. PMID 14623441 DOI: 10.1016/J.Mod.2003.05.002  0.389
2003 Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG. Ets2-dependent stromal regulation of mouse mammary tumors. Molecular and Cellular Biology. 23: 8614-25. PMID 14612405 DOI: 10.1128/Mcb.23.23.8614-8625.2003  0.665
2003 Lambert V, Wielockx B, Munaut C, Galopin C, Jost M, Itoh T, Werb Z, Baker A, Libert C, Krell HW, Foidart JM, Noël A, Rakic JM. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization Faseb Journal. 17: 2290-2292. PMID 14563686 DOI: 10.1096/Fj.03-0113Fje  0.362
2003 Heissig B, Werb Z, Rafii S, Hattori K. Role of c-kit/Kit ligand signaling in regulating vasculogenesis Thrombosis and Haemostasis. 90: 570-576. PMID 14515175 DOI: 10.1160/Th03-03-0188  0.397
2003 Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S, Werb Z. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. The Journal of Cell Biology. 162: 1123-33. PMID 12975354 DOI: 10.1083/Jcb.200302090  0.39
2003 Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. The Embo Journal. 22: 4794-803. PMID 12970191 DOI: 10.1093/Emboj/Cdg482  0.346
2003 Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. Journal of Neurosurgery. 99: 188-97. PMID 12956462 DOI: 10.3171/Spi.2003.99.2.0188  0.341
2003 Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. Journal of Neuroscience Research. 73: 644-58. PMID 12929132 DOI: 10.1002/Jnr.10701  0.729
2003 Solberg H, Rinkenberger J, Danø K, Werb Z, Lund LR. A functional overlap of plasminogen and MMPs regulates vascularization during placental development Development. 130: 4439-4450. PMID 12900459 DOI: 10.1242/Dev.00642  0.368
2003 Colnot C, Thompson Z, Miclau T, Werb Z, Helms JA. Altered fracture repair in the abscence of MMP9 Development. 130: 4123-4133. PMID 12874132 DOI: 10.1242/Dev.00559  0.375
2003 Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 3: 589-601. PMID 12842087 DOI: 10.1016/S1535-6108(03)00133-8  0.416
2003 Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R. Role of collagen type II and perlecan in skeletal development. Annals of the New York Academy of Sciences. 995: 140-50. PMID 12814946 DOI: 10.1111/J.1749-6632.2003.Tb03217.X  0.357
2003 Ortega N, Behonick D, Stickens D, Werb Z. How proteases regulate bone morphogenesis Annals of the New York Academy of Sciences. 995: 109-116. PMID 12814943 DOI: 10.1111/J.1749-6632.2003.Tb03214.X  0.41
2003 Heissig B, Hattori K, Friedrich M, Rafii S, Werb Z. Angiogenesis: Vascular remodeling of the extracellular matrix involves metalloproteinases Current Opinion in Hematology. 10: 136-141. PMID 12579040 DOI: 10.1097/00062752-200303000-00007  0.422
2003 Rosen J, Welm B, Tepera S, Behbod F, Grimm S, Venezia T, Goodell M, Graubert T, Werb Z, Li Y, Varmus H. Functional characterization of mammary stem cells in development and breast cancer Breast Cancer Research. 5. DOI: 10.1186/Bcr710  0.445
2002 Coussens LM, Werb Z. Inflammation and cancer Nature. 420: 860-867. PMID 12490959 DOI: 10.1038/Nature01322  0.586
2002 Ortega N, Werb Z. New functional roles for non-collagenous domains of basement membrane collagens Journal of Cell Science. 115: 4201-4214. PMID 12376553 DOI: 10.1242/Jcs.00106  0.34
2002 Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. The American Journal of Pathology. 161: 1429-37. PMID 12368215 DOI: 10.1016/S0002-9440(10)64418-5  0.355
2002 Lambert V, Munaut C, Jost M, Noël A, Werb Z, Foidart JM, Rakic JM. Matrix metalloproteinase-9 contributes to choroidal neovascularization American Journal of Pathology. 161: 1247-1253. PMID 12368198 DOI: 10.1016/S0002-9440(10)64401-X  0.377
2002 Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z, Bissell MJ. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell. 2: 205-216. PMID 12242153 DOI: 10.1016/S1535-6108(02)00125-3  0.551
2002 Werner E, Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases Journal of Cell Biology. 158: 357-368. PMID 12119354 DOI: 10.1083/Jcb.200111028  0.313
2002 Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MAS, Werb Z, et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment Nature Medicine. 8: 841-849. PMID 12091880 DOI: 10.1038/Nm740  0.352
2002 Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MAS, Werb Z, Rafii S. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand Cell. 109: 625-637. PMID 12062105 DOI: 10.1016/S0092-8674(02)00754-7  0.38
2002 Wiseman BS, Werb Z. Development: Stromal effects on mammary gland development and breast cancer Science. 296: 1046-1049. PMID 12004111 DOI: 10.1126/Science.1067431  0.379
2002 Lilla J, Stickens D, Werb Z. Metalloproteases and adipogenesis: A weighty subject American Journal of Pathology. 160: 1551-1554. PMID 12000705 DOI: 10.1016/S0002-9440(10)61100-5  0.769
2002 Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nature Reviews. Cancer. 2: 161-74. PMID 11990853 DOI: 10.1038/nrc745  0.643
2002 Welm B, Mott J, Werb Z. Developmental biology: vasculogenesis is a wreck without RECK Current Biology : Cb. 12: R209-211. PMID 11909548 DOI: 10.1016/S0960-9822(02)00752-2  0.313
2002 Corry DB, Rishi K, Kanellis J, Kiss A, Song Lz LZ, Xu J, Feng L, Werb Z, Kheradmand F. Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nature Immunology. 3: 347-53. PMID 11887181 DOI: 10.1038/Ni773  0.394
2002 Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression Nature Reviews Cancer. 2: 161-174. DOI: 10.1038/Nrc745  0.386
2002 Kheradmand F, Werb Z. Shedding light on sheddases: Role in growth and development Bioessays. 24: 8-12. DOI: 10.1002/Bies.10037  0.346
2001 Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior Annual Review of Cell and Developmental Biology. 17: 463-516. PMID 11687497 DOI: 10.1146/Annurev.Cellbio.17.1.463  0.407
2001 Chang C, Werb Z. The many faces of metalloproteases: Cell growth, invasion, angiogenesis and metastasis Trends in Cell Biology. 11: S37-S43. PMID 11684441 DOI: 10.1016/S0962-8924(01)02122-5  0.469
2001 Chen R, Ning G, Zhao ML, Fleming MG, Diaz LA, Werb Z, Liu Z. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. The Journal of Clinical Investigation. 108: 1151-8. PMID 11602622 DOI: 10.1172/Jci11494  0.323
2001 Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia (New York, N.Y.). 3: 339-50. PMID 11571634 DOI: 10.1038/Sj.Neo.7900170  0.339
2001 Lelongt B, Bengatta S, Delauche M, Lund LR, Werb Z, Ronco PM. Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. The Journal of Experimental Medicine. 193: 793-802. PMID 11283152 DOI: 10.1084/Jem.193.7.793  0.36
2001 Coussens LM, Werb Z. Inflammatory cells and cancer: think different! The Journal of Experimental Medicine. 193: F23-6. PMID 11257144 DOI: 10.1084/Jem.193.6.F23  0.605
2001 Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation Nature Cell Biology. 3: 267-275. PMID 11231576 DOI: 10.1038/35060059  0.344
2001 Coussens LM, Shapiro SD, Soloway PD, Werb Z. Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice. Methods in Molecular Biology (Clifton, N.J.). 151: 149-79. PMID 11217297 DOI: 10.1385/1-59259-046-2:149  0.554
2001 Yamada E, Tobe T, Yamada H, Okamoto N, Zack DJ, Werb Z, Soloway PD, Campochiaro PA. TIMP-1 promotes VEGF-induced neovascularization in the retina. Histology and Histopathology. 16: 87-97. PMID 11193216 DOI: 10.14670/Hh-16.87  0.377
2000 Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell. 103: 481-90. PMID 11081634 DOI: 10.1016/S0092-8674(00)00139-2  0.72
2000 Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaissé JM. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. The Journal of Cell Biology. 151: 879-89. PMID 11076971 DOI: 10.1083/Jcb.151.4.879  0.372
2000 Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biology. 2: 737-44. PMID 11025665 DOI: 10.1038/35036374  0.569
2000 Liu Z, Zhou X, Shapiro SD, Shipley JM, Twining SS, Diaz LA, Senior RM, Werb Z. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo Cell. 102: 647-655. PMID 11007483 DOI: 10.1016/S0092-8674(00)00087-8  0.328
2000 Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes & Development. 14: 2123-33. PMID 10970876 DOI: 10.1101/Gad.815400  0.395
2000 Cunha GR, Wiesen JF, Werb Z, Young P, Hom YK, Cooke PS, Lubahn DB. Paracrine mechanisms of mouse mammary ductal growth Advances in Experimental Medicine and Biology. 480: 93-97. PMID 10959414 DOI: 10.1007/0-306-46832-8_11  0.34
2000 Wiesen J, Werb Z. Proteinases, cell cycle regulation, and apoptosis during mammary gland involution (minireview). Molecular Reproduction and Development. 56: 534-40. PMID 10911404 DOI: 10.1002/1098-2795(200008)56:4<534::Aid-Mrd12>3.0.Co;2-O  0.314
2000 Rinkenberger J, Werb Z. The labyrinthine placenta. Nature Genetics. 25: 248-50. PMID 10888863 DOI: 10.1038/76985  0.301
2000 Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. The Journal of Clinical Investigation. 106: 55-62. PMID 10880048 DOI: 10.1172/Jci8768  0.353
2000 Sternlicht MD, Bissell MJ, Werb Z. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter Oncogene. 19: 1102-1113. PMID 10713697 DOI: 10.1038/Sj.Onc.1203347  0.463
2000 Heyer BS, MacAuley A, Behrendtsen O, Werb Z. Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. Genes & Development. 14: 2072-2084. DOI: 10.1101/Gad.14.16.2072  0.323
1999 Lochter A, Werb Z, Bissell MJ. Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant Matrix Biology. 18: 455-467. PMID 10601733 DOI: 10.1016/S0945-053X(99)00036-0  0.439
1999 Sternlicht MD, Lochtest A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis Cell. 98: 137-146. PMID 10428026 DOI: 10.1016/S0092-8674(00)81009-0  0.461
1999 Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nature Medicine. 5: 623-8. PMID 10371499 DOI: 10.1038/9467  0.325
1999 Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey GH, Hanahan D. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes & Development. 13: 1382-97. PMID 10364156 DOI: 10.1101/Gad.13.11.1382  0.729
1999 Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nature Genetics. 22: 69-73. PMID 10319864 DOI: 10.1038/8773  0.354
1999 Werb Z, Vu TH, Rinkenberger JL, Coussens LM. Matrix-degrading proteases and angiogenesis during development and tumor formation. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 107: 11-8. PMID 10190275 DOI: 10.1111/J.1699-0463.1999.Tb01521.X  0.617
1999 Lochter A, Sternlicht MD, Werb Z, Bissell MJ. The significance of matrix metalloproteinases during early stages of tumor progression. Annals of the New York Academy of Sciences. 857: 180-93. PMID 9917841 DOI: 10.1111/J.1749-6632.1998.Tb10116.X  0.458
1999 Werb Z, Chin JR. Extracellular matrix remodeling during morphogenesis. Annals of the New York Academy of Sciences. 857: 110-8. PMID 9917836 DOI: 10.1111/J.1749-6632.1998.Tb10111.X  0.389
1999 Cross JC, Lam S, Yagel S, Werb Z. Defective induction of the transcription factor interferon-stimulated gene factor-3 and interferon alpha insensitivity in human trophoblast cells. Biology of Reproduction. 60: 312-21. PMID 9915996 DOI: 10.1095/Biolreprod60.2.312  0.302
1999 Lukashev ME, Werb Z. ECM signalling: orchestrating cell behaviour and misbehaviour. Trends in Cell Biology. 8: 437-41. PMID 9854310 DOI: 10.1016/S0962-8924(98)01362-2  0.398
1999 Oh LYS, Larsen PH, Krekoski CA, Edwards DR, Donovan F, Werb Z, Yong VW. Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes The Journal of Neuroscience. 19: 8464-8475. DOI: 10.1523/Jneurosci.19-19-08464.1999  0.36
1998 Werb Z, Yan Y. A cellular striptease act. Science (New York, N.Y.). 282: 1279-80. PMID 9867633 DOI: 10.1126/Science.282.5392.1279  0.308
1998 Uria JA, Werb Z. Matrix metalloproteinases and their expression in mammary gland. Cell Research. 8: 187-94. PMID 9791732 DOI: 10.1038/Cr.1998.19  0.425
1998 Thomasset N, Lochter A, Sympson CJ, Lund LR, Williams DR, Behrendtsen O, Werb Z, Bissell MJ. Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. The American Journal of Pathology. 153: 457-67. PMID 9708806 DOI: 10.1016/S0002-9440(10)65589-7  0.436
1998 Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 93: 411-22. PMID 9590175 DOI: 10.1016/S0092-8674(00)81169-1  0.559
1998 Yamamoto H, Flannery ML, Kupriyanov S, Pearce J, McKercher SR, Henkel GW, Maki RA, Werb Z, Oshima RG. Defective trophoblast function in mice with a targeted mutation of Ets2. Genes & Development. 12: 1315-26. PMID 9573048 DOI: 10.1101/Gad.12.9.1315  0.418
1998 Kheradmand F, Werner E, Tremble P, Symons M, Werb Z. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science (New York, N.Y.). 280: 898-902. PMID 9572733 DOI: 10.1126/Science.280.5365.898  0.387
1998 MacAuley A, Cross JC, Werb Z. Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells. Molecular Biology of the Cell. 9: 795-807. PMID 9529378 DOI: 10.1091/Mbc.9.4.795  0.34
1998 Hom YK, Young P, Wiesen JF, Miettinen PJ, Derynck R, Werb Z, Cunha GR. Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology. 139: 913-21. PMID 9492020 DOI: 10.1210/Endo.139.3.5817  0.314
1998 Horwitz AR, Werb Z. Cell adhesion and the extracellular matrix: Recent progress and emerging themes Current Opinion in Cell Biology. 10: 563-565. DOI: 10.1016/S0955-0674(98)80029-X  0.382
1997 Lochter A, Galosy S, Muschler J, Freedman N, Werb Z, Bissell MJ. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells Journal of Cell Biology. 139: 1861-1872. PMID 9412478 DOI: 10.1083/Jcb.139.7.1861  0.46
1997 Werb Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell. 91: 439-42. PMID 9390552 DOI: 10.1016/S0092-8674(00)80429-8  0.324
1997 Padgett LC, Lui GM, Werb Z, LaVail MM. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation. Experimental Eye Research. 64: 927-38. PMID 9301473 DOI: 10.1006/Exer.1997.0287  0.382
1997 Newman-Smith E, Werb Z. Functional analysis of trophoblast giant cells in parthenogenetic mouse embryos. Developmental Genetics. 20: 1-10. PMID 9094206 DOI: 10.1002/(Sici)1520-6408(1997)20:1<1::Aid-Dvg1>3.0.Co;2-B  0.395
1997 Lochter A, Srebrow A, Sympson CJ, Terracio N, Werb Z, Bissell MJ. Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. The Journal of Biological Chemistry. 272: 5007-15. PMID 9030563 DOI: 10.1074/Jbc.272.8.5007  0.456
1997 Behrendtsen O, Werb Z. Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 208: 255-65. PMID 9022062 DOI: 10.1002/(Sici)1097-0177(199702)208:2<255::Aid-Aja12>3.0.Co;2-2  0.407
1997 La Fleur M, Underwood JL, Rappolee DA, Werb Z. Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. The Journal of Experimental Medicine. 184: 2311-26. PMID 8976186 DOI: 10.1084/Jem.184.6.2311  0.334
1997 Coussens LM, Werb Z. Matrix metalloproteinases and the development of cancer. Chemistry & Biology. 3: 895-904. PMID 8939708 DOI: 10.1016/S1074-5521(96)90178-7  0.633
1997 Basbaum CB, Werb Z. Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. Current Opinion in Cell Biology. 8: 731-8. PMID 8939664 DOI: 10.1016/S0955-0674(96)80116-5  0.398
1997 Lochter A, Werb Z, Bissell M. Matrix metaloproteases as proto-oncogenes Matrix Biology. 16: 75. DOI: 10.1016/S0945-053X(97)90093-7  0.318
1996 Alexander CM, Howard EW, Bissell MJ, Werb Z. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene Journal of Cell Biology. 135: 1669-1677. PMID 8978831 DOI: 10.1083/Jcb.135.6.1669  0.425
1996 Huttenlocher A, Werb Z, Tremble P, Huhtala P, Rosenberg L, Damsky CH. Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin Matrix Biology. 15: 239-250. PMID 8892224 DOI: 10.1016/S0945-053X(96)90115-8  0.431
1996 Logan SK, Hansell EJ, Damsky CH, Werb Z. T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40. Matrix Biology : Journal of the International Society For Matrix Biology. 15: 81-9. PMID 8837009 DOI: 10.1016/S0945-053X(96)90149-3  0.377
1996 Wiesen JF, Werb Z. The role of stromelysin-1 in stromal-epithelial interactions and cancer. Enzyme & Protein. 49: 174-81. PMID 8797005 DOI: 10.1159/000468624  0.317
1996 Hansell EJ, Frisch SM, Tremble P, Murnane JP, Werb Z. Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 73: 373-89. PMID 8703410 DOI: 10.1139/O95-045  0.364
1996 Boudreau N, Werb Z, Bissell MJ. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 93: 3509-13. PMID 8622967 DOI: 10.1073/Pnas.93.8.3509  0.362
1996 Sympson CJ, Bissell MJ, Werb Z. Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. Seminars in Cancer Biology. 6: 159-63. PMID 7495984 DOI: 10.1006/Scbi.1995.0022  0.423
1995 Tremble P, Damsky CH, Werb Z. Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. The Journal of Cell Biology. 129: 1707-20. PMID 7790365 DOI: 10.1083/Jcb.129.6.1707  0.347
1995 Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 376: 337-41. PMID 7630400 DOI: 10.1038/376337A0  0.301
1995 Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. The Journal of Cell Biology. 129: 867-79. PMID 7537277 DOI: 10.1083/Jcb.129.3.867  0.352
1995 Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (New York, N.Y.). 267: 891-3. PMID 7531366 DOI: 10.1126/Science.7531366  0.365
1995 Sympson CJ, Talhouk RS, Bissell MJ, Werb Z. The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo Perspectives in Drug Discovery and Design. 2: 401-411. DOI: 10.1007/Bf02172033  0.441
1994 Sympson CJ, Talhouk RS, Alexander CM, Chin JR, Clift SM, Bissell MJ, Werb Z. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. The Journal of Cell Biology. 125: 681-93. PMID 8175886 DOI: 10.1083/Jcb.125.3.681  0.401
1994 Tremble P, Chiquet-Ehrismann R, Werb Z. The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts. Molecular Biology of the Cell. 5: 439-53. PMID 7519905 DOI: 10.1091/Mbc.5.4.439  0.378
1993 Tremble PM, Lane TF, Sage EH, Werb Z. SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. The Journal of Cell Biology. 121: 1433-44. PMID 8509459 DOI: 10.1083/Jcb.121.6.1433  0.409
1992 Alexander CM, Werb Z. Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro Journal of Cell Biology. 118: 727-739. PMID 1639854 DOI: 10.1083/Jcb.118.3.727  0.42
1992 Talhouk RS, Bissell MJ, Werb Z. Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. The Journal of Cell Biology. 118: 1271-82. PMID 1512297 DOI: 10.1083/Jcb.118.5.1271  0.385
1992 Damsky CH, Werb Z. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Current Opinion in Cell Biology. 4: 772-81. PMID 1329869 DOI: 10.1016/0960-9822(92)90186-E  0.329
1992 Hu C, Sakakura Y, Sasano Y, Shum L, Bringas P, Werb Z, Slavkin HC. Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis. The International Journal of Developmental Biology. 36: 505-516. DOI: 10.1387/Ijdb.1295561  0.303
1991 Werb Z, Tremble P, Damsky CH. Regulation of extracellular matrix degradation by cell-extracellular matrix interactions. Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists. 32: 299-306. PMID 2151566 DOI: 10.1016/0922-3371(90)90043-V  0.355
1991 Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky CH, Fisher SJ. 92-kD type IV collagenase mediates invasion of human cytotrophoblasts. The Journal of Cell Biology. 113: 437-49. PMID 1849141 DOI: 10.1083/Jcb.113.2.437  0.394
1990 Rappolee DA, Werb Z. mRNA phenotyping for studying gene expression in small numbers of cells: platelet-derived growth factor and other growth factors in wound-derived macrophages. American Journal of Respiratory Cell and Molecular Biology. 2: 3-10. PMID 2407272 DOI: 10.1165/Ajrcmb/2.1.3  0.34
1990 Crocker P, Werb Z, Gordon S, Bainton D. Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters Blood. 76: 1131-1138. DOI: 10.1182/Blood.V76.6.1131.1131  0.492
1990 Crocker P, Werb Z, Gordon S, Bainton D. Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters Blood. 76: 1131-1138. DOI: 10.1182/blood.v76.6.1131.1131  0.425
1989 Brenner CA, Adler RR, Rappolee DA, Pedersen RA, Werb Z. Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. Genes & Development. 3: 848-59. PMID 2744464 DOI: 10.1101/Gad.3.6.848  0.395
1989 Alexander CM, Werb Z. Proteinases and extracellular remodeling Current Opinion in Cell Biology. 1: 974-982. PMID 2697298 DOI: 10.1016/0955-0674(89)90068-9  0.329
1989 Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. The Journal of Cell Biology. 109: 877-89. PMID 2547805 DOI: 10.1083/Jcb.109.2.877  0.348
1988 Rappolee DA, Mark D, Banda MJ, Werb Z. Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping Science. 241: 708-712. PMID 3041594 DOI: 10.1126/Science.3041594  0.324
1987 Frisch SM, Clark EJ, Werb Z. Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes. Proceedings of the National Academy of Sciences of the United States of America. 84: 2600-4. PMID 3033652 DOI: 10.1073/Pnas.84.9.2600  0.338
1987 Chan LM, Hatier C, Parry G, Werb Z, Bissell MJ. Collagen-fibronectin interactions in normal and Rous sarcoma virus-transformed avian tendon cells: possible mechanisms for increased extracellular matrix turnover after transformation. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 23: 308-14. PMID 3032890 DOI: 10.1007/Bf02623715  0.358
1986 Unemori EN, Werb Z. Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels. The Journal of Cell Biology. 103: 1021-31. PMID 3017994 DOI: 10.1083/Jcb.103.3.1021  0.389
1986 Werb Z, Hembry RM, Murphy G, Aggeler J. Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture. The Journal of Cell Biology. 102: 697-702. PMID 3005336 DOI: 10.1083/Jcb.102.3.697  0.316
1985 Murphy G, Werb Z. Tissue inhibitor of metalloproteinases. Identification of precursor forms synthesized by human fibroblasts in culture. Biochimica Et Biophysica Acta. 839: 214-8. PMID 3886013 DOI: 10.1016/0304-4165(85)90039-X  0.342
1984 Takemura R, Werb Z. Secretory products of macrophages and their physiological functions. The American Journal of Physiology. 246: C1-9. PMID 6364825 DOI: 10.1152/Ajpcell.1984.246.1.C1  0.31
1984 Aggeler J, Frisch SM, Werb Z. Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts. The Journal of Cell Biology. 98: 1662-71. PMID 6327718 DOI: 10.1083/Jcb.98.5.1662  0.366
1984 Aggeler J, Frisch SM, Werb Z. Collagenase is a major gene product of induced rabbit synovial fibroblasts Journal of Cell Biology. 98: 1656-1661. PMID 6327717 DOI: 10.1083/Jcb.98.5.1656  0.327
1983 Werb Z, Chin JR. Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages. The Journal of Experimental Medicine. 158: 1272-93. PMID 6619735 DOI: 10.1084/Jem.158.4.1272  0.312
1983 Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ. Oxygen tension regulates the expression of angiogenesis factor by macrophages Science. 221: 1283-1285. PMID 6612342 DOI: 10.1126/Science.6612342  0.326
1983 Werb Z, Chin JR. Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes. The Journal of Cell Biology. 97: 1113-8. PMID 6604729 DOI: 10.1083/Jcb.97.4.1113  0.334
1983 Glass RH, Aggeler J, Spindle A, Pedersen RA, Werb Z. Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation. The Journal of Cell Biology. 96: 1108-16. PMID 6339525 DOI: 10.1083/Jcb.96.4.1108  0.361
1982 Aggeler J, Kapp LN, Tseng SC, Werb Z. Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density. Plasminogen activator, procollagen fibronectin. Experimental Cell Research. 139: 275-83. PMID 7200903 DOI: 10.1016/0014-4827(82)90252-X  0.378
1982 Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes. Requirement for reactive metabolites of oxygen Journal of Clinical Investigation. 69: 876-888. PMID 7076851 DOI: 10.1172/Jci110527  0.302
1982 Banda MJ, Knighton DR, Hunt TK, Werb Z. Isolation of a nonmitogenic angiogenesis factor from wound fluid Proceedings of the National Academy of Sciences of the United States of America. 79: 7773-7777. PMID 6961449 DOI: 10.1073/Pnas.79.24.7773  0.328
1982 Werb Z, Banda MJ, Mckerrow JH, Sandhaus RA. Elastases and Elastin Degradation Journal of Investigative Dermatology. 79: 154-159. DOI: 10.1038/Jid.1982.28  0.303
1981 Banda MJ, Werb Z. Mouse macrophage elastase. Purification and characterization as a metalloproteinase Biochemical Journal. 193: 589-605. PMID 7030312 DOI: 10.1042/Bj1930589  0.327
1981 Werb Z, Bainton DF, Jones PA. Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. The Journal of Experimental Medicine. 152: 1537-53. PMID 7005386 DOI: 10.1084/Jem.152.6.1537  0.356
1981 Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters Journal of Clinical Investigation. 67: 1324-1333. PMID 6939690 DOI: 10.1172/Jci110161  0.394
1981 Aggeler J, Risch J, Werb Z. Expression of the catalytic activity of plasminogen activator under physiologic conditions Bba - General Subjects. 675: 62-68. PMID 6455162 DOI: 10.1016/0304-4165(81)90069-6  0.351
1981 Jones PA, Werb Z. Degradation of connective tissue matrices by macrophages. II. Influence of matrix composition on proteolysis of glycoproteins, elastin, and collagen by macrophages in culture. The Journal of Experimental Medicine. 152: 1527-36. PMID 6450258 DOI: 10.1084/Jem.152.6.1527  0.368
1980 Werb Z, Banda MJ, Jones PA. Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages Journal of Experimental Medicine. 152: 1340-1357. PMID 7000966 DOI: 10.1084/Jem.152.5.1340  0.354
1978 Werb Z. Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions. The Journal of Experimental Medicine. 147: 1695-1712. PMID 210248 DOI: 10.1084/Jem.147.6.1695  0.312
1978 Werb Z, Aggeler J. Proteases induce secretion of collagenase and plasminogen activator by fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 75: 1839-43. PMID 205872 DOI: 10.1073/Pnas.75.4.1839  0.382
1978 Werb Z, Dingle JT, Reynolds JJ, Barrett AJ. Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. The Biochemical Journal. 173: 949-58. PMID 30451 DOI: 10.1042/Bj1730949  0.543
1977 Werb Z, Mainardi CL, Vater CA, Harris ED. Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. The New England Journal of Medicine. 296: 1017-23. PMID 66627 DOI: 10.1056/Nejm197705052961801  0.313
1976 Werb Z, Dingle JT. Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. Frontiers of Biology. 45: 127-56. PMID 185097  0.466
1976 Gordon S, Werb Z. Secretion of macrophage neutral proteinase is enhanced by colchicine. Proceedings of the National Academy of Sciences of the United States of America. 73: 872-6. PMID 176659 DOI: 10.1073/Pnas.73.3.872  0.487
1976 Werb Z, Reynolds JJ. Rabbit collagenase. Immunological identity of the enzymes released from cells and tissues in normal and pathological conditions. The Biochemical Journal. 151: 665-69. PMID 56176 DOI: 10.1042/Bj1510665  0.32
1975 Harris ED, Reynolds JJ, Werb Z. Cytochalasin B increases collagenase production by cells in vitro. Nature. 257: 243-4. PMID 169478 DOI: 10.1038/257243A0  0.336
1975 Werb Z, Gordon S. Elastase secretion by stimulated macrophages. Characterization and regulation. The Journal of Experimental Medicine. 142: 361-77. PMID 167096 DOI: 10.1084/Jem.142.2.361  0.507
1975 Werb Z, Gordon S. Secretion of a specific collagenase by stimulated macrophages. The Journal of Experimental Medicine. 142: 346-60. PMID 167095 DOI: 10.1084/Jem.142.2.346  0.501
1974 Werb Z, Cohn ZA. The preparation of macrophage lysosomes and phagolysosomes. Methods in Enzymology. 31: 339-45. PMID 4608929 DOI: 10.1016/0076-6879(74)31036-1  0.489
1974 Werb Z, Burleigh MC. A specific collagenase from rabbit fibroblasts in monolayer culture. The Biochemical Journal. 137: 373-85. PMID 4363113 DOI: 10.1042/Bj1370373  0.316
1973 WERB Z, BURLEIGH MC, REYNOLDS JJ. Production of a Specific Collagenase by Rabbit Synovial Cells in Continuous Cell Culture Biochemical Society Transactions. 1: 379-379. DOI: 10.1042/Bst0010379  0.318
1972 Werb Z, Cohn ZA. Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. The Journal of Biological Chemistry. 247: 2439-46. PMID 5019957  0.405
1972 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. 3. Ingestion and intracellular fate of cholesterol and cholesterol esters. The Journal of Experimental Medicine. 135: 21-44. PMID 4550608 DOI: 10.1084/Jem.135.1.21  0.475
1971 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. The Journal of Experimental Medicine. 134: 1545-69. PMID 5126640 DOI: 10.1084/Jem.134.6.1545  0.489
1971 Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. II. Alteration of subcellular exchangeable cholesterol compartments and exchange in other cell types. The Journal of Experimental Medicine. 134: 1570-90. PMID 4942408 DOI: 10.1084/Jem.134.6.1570  0.5
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