Wouter de Laat - Publications

Affiliations: 
Erasmus Medical Center Rotterdam, Rotterdam, Netherlands 

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Vermeulen C, Allahyar A, Bouwman BAM, Krijger PHL, Verstegen MJAM, Geeven G, Valdes-Quezada C, Renkens I, Straver R, Kloosterman WP, de Ridder J, de Laat W. Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies. Nature Protocols. PMID 31932773 DOI: 10.1038/s41596-019-0242-7  0.32
2019 van den Boogaard M, van Weerd JH, Bawazeer AC, Hooijkaas IB, van de Werken HJG, Tessadori F, de Laat W, Barnett P, Bakkers J, Christoffels VM. Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation. Cell Reports. 28: 2704-2714.e5. PMID 31484079 DOI: 10.1016/j.celrep.2019.08.007  0.32
2018 Geeven G, Teunissen H, de Laat W, de Wit E. peakC: a flexible, non-parametric peak calling package for 4C and Capture-C data. Nucleic Acids Research. PMID 29800273 DOI: 10.1093/nar/gky443  0.32
2017 Vermeulen C, Geeven G, de Wit E, Verstegen MJAM, Jansen RPM, van Kranenburg M, de Bruijn E, Pulit SL, Kruisselbrink E, Shahsavari Z, Omrani D, Zeinali F, Najmabadi H, Katsila T, Vrettou C, ... ... de Laat W, et al. Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping. American Journal of Human Genetics. PMID 28844486 DOI: 10.1016/j.ajhg.2017.07.012  0.72
2016 Wang X, Tucker NR, Rizki G, Mills R, Krijger PH, de Wit E, Subramanian V, Bartell E, Nguyen XX, Ye J, Leyton-Mange J, Dolmatova EV, van der Harst P, de Laat W, Ellinor PT, et al. Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures. Elife. 5. PMID 27162171 DOI: 10.7554/eLife.10557  0.32
2016 Krijger PH, Di Stefano B, de Wit E, Limone F, van Oevelen C, de Laat W, Graf T. Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming. Cell Stem Cell. PMID 26971819 DOI: 10.1016/j.stem.2016.01.007  0.96
2016 Wijchers PJ, Krijger PH, Geeven G, Zhu Y, Denker A, Verstegen MJ, Valdes-Quezada C, Vermeulen C, Janssen M, Teunissen H, Anink-Groenen LC, Verschure PJ, de Laat W. Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments. Molecular Cell. PMID 26833089 DOI: 10.1016/j.molcel.2016.01.001  0.96
2016 Vermunt MW, Tan SC, Castelijns B, Geeven G, Reinink P, de Bruijn E, Kondova I, Persengiev S, Bontrop R, Cuppen E, de Laat W, Creyghton MP. Epigenomic annotation of gene regulatory alterations during evolution of the primate brain. Nature Neuroscience. PMID 26807951 DOI: 10.1038/nn.4229  0.96
2016 Melo CA, Léveillé N, Rooijers K, Wijchers PJ, Geeven G, Tal A, Melo SA, de Laat W, Agami R. A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response Oncogene. DOI: 10.1038/onc.2015.502  0.32
2015 Geeven G, Zhu Y, Kim BJ, Bartholdy BA, Yang SM, Macfarlan TS, Gifford WD, Pfaff SL, Verstegen MJ, Pinto H, Vermunt MW, Creyghton MP, Wijchers PJ, Stamatoyannopoulos JA, Skoultchi AI, ... de Laat W, et al. Local compartment changes and regulatory landscape alterations in histone H1-depleted cells. Genome Biology. 16: 289. PMID 26700097 DOI: 10.1186/s13059-015-0857-0  0.96
2015 Austenaa LM, Barozzi I, Simonatto M, Masella S, Della Chiara G, Ghisletti S, Curina A, de Wit E, Bouwman BA, de Pretis S, Piccolo V, Termanini A, Prosperini E, Pelizzola M, de Laat W, et al. Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination. Molecular Cell. 60: 460-74. PMID 26593720 DOI: 10.1016/j.molcel.2015.09.018  0.96
2015 Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL. Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. Bmc Genomics. 16: 982. PMID 26589460 DOI: 10.1186/s12864-015-2137-5  0.96
2015 de Wit E, Vos ES, Holwerda SJ, Valdes-Quezada C, Verstegen MJ, Teunissen H, Splinter E, Wijchers PJ, Krijger PH, de Laat W. CTCF Binding Polarity Determines Chromatin Looping. Molecular Cell. PMID 26527277 DOI: 10.1016/j.molcel.2015.09.023  0.96
2015 Galli GG, Carrara M, Yuan WC, Valdes-Quezada C, Gurung B, Pepe-Mooney B, Zhang T, Geeven G, Gray NS, de Laat W, Calogero RA, Camargo FD. YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers. Molecular Cell. PMID 26439301 DOI: 10.1016/j.molcel.2015.09.001  0.96
2015 Ramírez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A. High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell. 60: 146-62. PMID 26431028 DOI: 10.1016/j.molcel.2015.08.024  0.96
2015 Denker A, de Laat W. A Long-Distance Chromatin Affair. Cell. 162: 942-3. PMID 26317462 DOI: 10.1016/j.cell.2015.08.022  0.96
2015 Bouwman BA, de Laat W. Getting the genome in shape: the formation of loops, domains and compartments. Genome Biology. 16: 154. PMID 26257189 DOI: 10.1186/s13059-015-0730-1  0.96
2015 Marks H, Kerstens HH, Barakat TS, Splinter E, Dirks RA, van Mierlo G, Joshi O, Wang SY, Babak T, Albers CA, Kalkan T, Smith A, Jouneau A, de Laat W, Gribnau J, et al. Dynamics of gene silencing during X inactivation using allele-specific RNA-seq. Genome Biology. 16: 149. PMID 26235224 DOI: 10.1186/s13059-015-0698-x  0.96
2015 Wijchers PJ, Geeven G, Eyres M, Bergsma AJ, Janssen M, Verstegen M, Zhu Y, Schell Y, Vermeulen C, de Wit E, de Laat W. Characterization and dynamics of pericentromere-associated domains in mice. Genome Research. 25: 958-69. PMID 25883320 DOI: 10.1101/gr.186643.114  0.96
2015 Léveillé N, Melo CA, Rooijers K, Díaz-Lagares A, Melo SA, Korkmaz G, Lopes R, Akbari Moqadam F, Maia AR, Wijchers PJ, Geeven G, den Boer ML, Kalluri R, de Laat W, Esteller M, et al. Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. Nature Communications. 6: 6520. PMID 25813522 DOI: 10.1038/ncomms7520  0.96
2015 Bouwman BAM, De Laat W. Architectural hallmarks of the pluripotent genome Febs Letters. DOI: 10.1016/j.febslet.2015.04.055  0.96
2014 Vermunt MW, Reinink P, Korving J, de Bruijn E, Creyghton PM, Basak O, Geeven G, Toonen PW, Lansu N, Meunier C, van Heesch S, Clevers H, de Laat W, Cuppen E, Creyghton MP. Large-scale identification of coregulated enhancer networks in the adult human brain Cell Reports. 9: 767-779. PMID 25373911 DOI: 10.1016/j.celrep.2014.09.023  0.96
2014 de Vree PJ, de Wit E, Yilmaz M, van de Heijning M, Klous P, Verstegen MJ, Wan Y, Teunissen H, Krijger PH, Geeven G, Eijk PP, Sie D, Ylstra B, Hulsman LO, van Dooren MF, ... ... de Laat W, et al. Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping. Nature Biotechnology. 32: 1019-25. PMID 25129690 DOI: 10.1038/nbt.2959  0.96
2014 Gröschel S, Sanders MA, Hoogenboezem R, De Wit E, Bouwman BAM, Erpelinck C, Van Der Velden VHJ, Havermans M, Avellino R, Van Lom K, Rombouts EJ, Van Duin M, Döhner K, Beverloo HB, Bradner JE, ... ... De Laat W, et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in Leukemia Cell. 157: 369-381. PMID 24703711 DOI: 10.1016/j.cell.2014.02.019  0.96
2014 van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression. The Journal of Clinical Investigation. 124: 1844-52. PMID 24642470 DOI: 10.1172/JCI73140  0.96
2014 Van Weerd JH, Badi I, Van Den Boogaard M, Stefanovic S, Van De Werken HJG, Gomez-Velazquez M, Badia-Careaga C, Manzanares M, De Laat W, Barnett P, Christoffels VM. A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system Circulation Research. 115: 432-441. DOI: 10.1161/CIRCRESAHA.115.303591  0.96
2013 de Laat W, Duboule D. Topology of mammalian developmental enhancers and their regulatory landscapes. Nature. 502: 499-506. PMID 24153303 DOI: 10.1038/nature12753  0.96
2013 Wijchers PJ, De Laat W. XFor genomes to stay in shape, insulators must be up to PAR Cell. 155: X15-16. PMID 24074855 DOI: 10.1016/j.cell.2013.09.012  0.96
2013 Denholtz M, Bonora G, Chronis C, Splinter E, de Laat W, Ernst J, Pellegrini M, Plath K. Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell. 13: 602-16. PMID 24035354 DOI: 10.1016/j.stem.2013.08.013  0.96
2013 De Wit E, Bouwman BAM, Zhu Y, Klous P, Splinter E, Verstegen MJAM, Krijger PHL, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, De Laat W. The pluripotent genome in three dimensions is shaped around pluripotency factors Nature. 501: 227-231. PMID 23883933 DOI: 10.1038/nature12420  0.96
2013 Holwerda SJB, Van De Werken HJG, Ribeiro De Almeida C, Bergen IM, De Bruijn MJW, Verstegen MJAM, Simonis M, Splinter E, Wijchers PJ, Hendriks RW, De Laat W. Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells Nucleic Acids Research. 41: 6905-6916. PMID 23748562 DOI: 10.1093/nar/gkt491  0.96
2013 Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, van Es JH, Schuijers J, de Wit E, de Laat W, Hannon GJ, Clevers HC, Smith AD, Ketting RF. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biology. 14: R50. PMID 23714178 DOI: 10.1186/gb-2013-14-5-r50  0.32
2013 Holwerda SJB, de Laat W. CTCF: the protein, the binding partners, the binding sites and their chromatin loops. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20120369. PMID 23650640 DOI: 10.1098/rstb.2012.0369  0.96
2013 Krijger PHL, De Laat W. Identical cells with different 3D genomes; cause and consequences? Current Opinion in Genetics and Development. 23: 191-196. PMID 23415810 DOI: 10.1016/j.gde.2012.12.010  0.96
2013 Eijkelenboom A, Mokry M, De Wit E, Smits LM, Polderman PE, Van Triest MH, Van Boxtel R, Schulze A, De Laat W, Cuppen E, Burgering BMT. Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling Molecular Systems Biology. 9. PMID 23340844 DOI: 10.1038/msb.2012.74  0.96
2013 Melo CA, Drost J, Wijchers PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Léveillé N, Kalluri R, de Laat W, Agami R. eRNAs are required for p53-dependent enhancer activity and gene transcription. Molecular Cell. 49: 524-35. PMID 23273978 DOI: 10.1016/j.molcel.2012.11.021  0.96
2012 de Laat W, Dekker J. 3C-based technologies to study the shape of the genome Methods. 58: 189-191. PMID 23199640 DOI: 10.1016/j.ymeth.2012.11.005  0.96
2012 Van De Werken HJG, Landan G, Holwerda SJB, Hoichman M, Klous P, Chachik R, Splinter E, Valdes-Quezada C, Öz Y, Bouwman BAM, Verstegen MJAM, De Wit E, Tanay A, De Laat W. Robust 4C-seq data analysis to screen for regulatory DNA interactions Nature Methods. 9: 969-972. PMID 22961246 DOI: 10.1038/nmeth.2173  0.96
2012 Van De Werken HJG, De Vree PJP, Splinter E, Holwerda SJB, Klous P, De Wit E, De Laat W. 4C technology: Protocols and data analysis Methods in Enzymology. 513: 89-112. PMID 22929766 DOI: 10.1016/B978-0-12-391938-0.00004-5  0.96
2012 Moindrot B, Audit B, Klous P, Baker A, Thermes C, De Laat W, Bouvet P, Mongelard F, Arneodo A. 3D chromatin conformation correlates with replication timing and is conserved in resting cells Nucleic Acids Research. 40: 9470-9481. PMID 22879376 DOI: 10.1093/nar/gks736  0.96
2012 Splinter E, de Wit E, van de Werken HJG, Klous P, de Laat W. Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation Methods. 58: 221-230. PMID 22609568 DOI: 10.1016/j.ymeth.2012.04.009  0.96
2012 de Wit E, de Laat W. A decade of 3C technologies: Insights into nuclear organization Genes and Development. 26: 11-24. PMID 22215806 DOI: 10.1101/gad.179804.111  0.96
2012 Holwerda S, de Laat W. Chromatin loops, gene positioning, and gene expression Frontiers in Genetics. 3. DOI: 10.3389/fgene.2012.00217  0.96
2011 Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, de Laat W, Spitz F, Duboule D. A regulatory archipelago controls Hox genes transcription in digits. Cell. 147: 1132-45. PMID 22118467 DOI: 10.1016/j.cell.2011.10.023  0.96
2011 Noordermeer D, Leleu M, Splinter E, Rougemont J, De Laat W, Duboule D. The dynamic architecture of Hox gene clusters. Science (New York, N.Y.). 334: 222-5. PMID 21998387 DOI: 10.1126/science.1207194  0.96
2011 Splinter E, De Laat W. The complex transcription regulatory landscape of our genome: Control in three dimensions Embo Journal. 30: 4345-4355. PMID 21952046 DOI: 10.1038/emboj.2011.344  0.96
2011 Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W. Variegated gene expression caused by cell-specific long-range DNA interactions. Nature Cell Biology. 13: 944-51. PMID 21706023 DOI: 10.1038/ncb2278  0.96
2011 Splinter E, de Wit E, Nora EP, Klous P, van de Werken HJG, Zhu Y, Kaaij LJT, van Ijcken W, Gribnau J, Heard E, de Laat W. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA Genes and Development. 25: 1371-1383. PMID 21690198 DOI: 10.1101/gad.633311  0.96
2011 Tena JJ, Alonso ME, De La Calle-Mustienes E, Splinter E, De Laat W, Manzanares M, Gómez-Skarmeta JL. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation Nature Communications. 2. PMID 21556064 DOI: 10.1038/ncomms1301  0.96
2011 Homminga I, Pieters R, Langerak AW, de Rooi JJ, Stubbs A, Verstegen M, Vuerhard M, Buijs-Gladdines J, Kooi C, Klous P, van Vlierberghe P, Ferrando AA, Cayuela JM, Verhaaf B, Beverloo HB, ... ... de Laat W, et al. Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia Cancer Cell. 19: 484-497. PMID 21481790 DOI: 10.1016/j.ccr.2011.02.008  0.96
2011 Hakim O, Sung MH, Voss TC, Splinter E, John S, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, de Laat W, Hager GL. Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements. Genome Research. 21: 697-706. PMID 21471403 DOI: 10.1101/gr.111153.110  0.96
2011 Tolhuis B, Blom M, Kerkhoven RM, Pagie L, Teunissen H, Nieuwland M, Simonis M, de Laat W, van Lohuizen M, van Steensel B. Interactions among polycomb domains are guided by chromosome architecture Plos Genetics. 7. PMID 21455484 DOI: 10.1371/journal.pgen.1001343  0.96
2011 Wijchers PJ, de Laat W. Genome organization influences partner selection for chromosomal rearrangements Trends in Genetics. 27: 63-71. PMID 21144612 DOI: 10.1016/j.tig.2010.11.001  0.96
2009 Simonis M, Klous P, Homminga I, Galjaard RJ, Rijkers EJ, Grosveld F, Meijerink JP, de Laat W. High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology. Nature Methods. 6: 837-42. PMID 19820713 DOI: 10.1038/nmeth.1391  0.96
2009 Louwers M, Splinter E, van Driel R, de Laat W, Stam M. Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C) Nature Protocols. 4: 1216-1229. PMID 19644461 DOI: 10.1038/nprot.2009.113  0.96
2009 Louwers M, Bader R, Haring M, Van Driel R, De Laat W, Stam M. Tissue- and expression level-specific chromatin looping at maize b1 epialleles Plant Cell. 21: 832-842. PMID 19336692 DOI: 10.1105/tpc.108.064329  0.96
2008 Noordermeer D, De Laat W. Joining the loops: β-globin gene regulation Iubmb Life. 60: 824-833. PMID 18767169 DOI: 10.1002/iub.129  0.96
2008 Simonis M, de Laat W. FISH-eyed and genome-wide views on the spatial organisation of gene expression Biochimica Et Biophysica Acta - Molecular Cell Research. 1783: 2052-2060. PMID 18721832 DOI: 10.1016/j.bbamcr.2008.07.020  0.96
2008 Guelen L, Pagie L, Brasset E, Meuleman W, Faza MB, Talhout W, Eussen BH, De Klein A, Wessels L, De Laat W, Van Steensel B. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions Nature. 453: 948-951. PMID 18463634 DOI: 10.1038/nature06947  0.96
2008 Noordermeer D, Branco MR, Splinter E, Klous P, Van Ijcken W, Swagemakers S, Koutsourakis M, Van Der Spek P, Pombo A, De Laat W. Transcription and chromatin organization of a housekeeping gene cluster containing an integrated β-globin locus control region Plos Genetics. 4. PMID 18369441 DOI: 10.1371/journal.pgen.1000016  0.96
2008 Palstra RJ, Simonis M, Klous P, Brasset E, Eijkelkamp B, de Laat W. Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. Plos One. 3: e1661. PMID 18286208 DOI: 10.1371/journal.pone.0001661  0.8
2008 de Laat W, Klous P, Kooren J, Noordermeer D, Palstra RJ, Simonis M, Splinter E, Grosveld F. Three-dimensional organization of gene expression in erythroid cells. Current Topics in Developmental Biology. 82: 117-39. PMID 18282519 DOI: 10.1016/S0070-2153(07)00005-1  0.96
2008 Palstra RJ, de Laat W, Grosveld F. Beta-globin regulation and long-range interactions. Advances in Genetics. 61: 107-42. PMID 18282504 DOI: 10.1016/S0065-2660(07)00004-1  0.96
2008 Palstra RJ, Simonis M, Klous P, Brasset E, Eijkelkamp B, de Laat W. Maintenane of long-ranage DNA interactions after inhibition of ongoing RNA polymerase II transcription Plos One. 3. DOI: 10.1371/journal.pone.0001661  0.96
2007 Simonis M, Kooren J, de Laat W. An evaluation of 3C-based methods to capture DNA interactions Nature Methods. 4: 895-901. PMID 17971780 DOI: 10.1038/nmeth1114  0.96
2007 de Laat W, Grosveld F. Inter-chromosomal gene regulation in the mammalian cell nucleus. Current Opinion in Genetics & Development. 17: 456-64. PMID 17884460 DOI: 10.1016/j.gde.2007.07.009  0.96
2007 Hagège H, Klous P, Braem C, Splinter E, Dekker J, Cathala G, de Laat W, Forné T. Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nature Protocols. 2: 1722-1733. PMID 17641637 DOI: 10.1038/nprot.2007.243  0.96
2007 de Laat W. Long-range DNA contacts: romance in the nucleus? Current Opinion in Cell Biology. 19: 317-320. PMID 17467258 DOI: 10.1016/j.ceb.2007.04.004  0.96
2007 Kooren J, Palstra RJ, Klous P, Splinter E, von Lindern M, Grosveld F, de Laat W. Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice. The Journal of Biological Chemistry. 282: 16544-52. PMID 17428799 DOI: 10.1074/jbc.M701159200  0.96
2007 Skok JA, Gisler R, Novatchkova M, Farmer D, de Laat W, Busslinger M. Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes Nature Immunology. 8: 378-387. PMID 17334367 DOI: 10.1038/ni1448  0.96
2006 Simonis M, Klous P, Splinter E, Moshkin Y, Willemsen R, De Wit E, Van Steensel B, De Laat W. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C) Nature Genetics. 38: 1348-1354. PMID 17033623 DOI: 10.1038/ng1896  0.96
2006 Splinter E, Heath H, Kooren J, Palstra RJ, Klous P, Grosveld F, Galjart N, de Laat W. CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes & Development. 20: 2349-54. PMID 16951251 DOI: 10.1101/gad.399506  0.96
2006 Augustin LM, van der Tol JJGM, Hanfoug R, de Laat W, van de Moosdijk M, Smit MK. A single etch-step polarization splitter on InP/InGaAsP with increased width tolerance Optics Infobase Conference Papers 0.01
2004 Drissen R, Palstra RJ, Gillemans N, Splinter E, Grosveld F, Philipsen S, de Laat W. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes & Development. 18: 2485-90. PMID 15489291 DOI: 10.1101/gad.317004  0.96
2004 Patrinos GP, de Krom M, de Boer E, Langeveld A, Imam AM, Strouboulis J, de Laat W, Grosveld FG. Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes & Development. 18: 1495-509. PMID 15198986 DOI: 10.1101/gad.289704  0.96
2004 Splinter E, Grosveld F, de Laat W. 3C technology: analyzing the spatial organization of genomic loci in vivo. Methods in Enzymology. 375: 493-507. PMID 14870685 DOI: 10.1016/S0076-6879(03)75030-7  0.96
2003 Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W. The beta-globin nuclear compartment in development and erythroid differentiation. Nature Genetics. 35: 190-4. PMID 14517543 DOI: 10.1038/ng1244  0.96
2003 de Laat W, Grosveld F. Spatial organization of gene expression: the active chromatin hub. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 11: 447-59. PMID 12971721 DOI: 10.1023/A:1024922626726  0.96
2002 Tolhuis B, Palstra RJ, Splinter E, Grosveld F, de Laat W. Looping and interaction between hypersensitive sites in the active beta-globin locus. Molecular Cell. 10: 1453-65. PMID 12504019 DOI: 10.1016/S1097-2765(02)00781-5  0.96
2001 Winkler GS, Sugasawa K, Eker AP, de Laat WL, Hoeijmakers JH. Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF. Biochemistry. 40: 160-5. PMID 11141066 DOI: 10.1021/bi002021b  0.96
1999 de Laat WL, Jaspers NG, Hoeijmakers JH. Molecular mechanism of nucleotide excision repair. Genes & Development. 13: 768-85. PMID 10197977  0.96
1998 de Laat WL, Sijbers AM, Odijk H, Jaspers NG, Hoeijmakers JH. Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucleic Acids Research. 26: 4146-52. PMID 9722633 DOI: 10.1093/nar/26.18.4146  0.96
1998 de Laat WL, Appeldoorn E, Sugasawa K, Weterings E, Jaspers NG, Hoeijmakers JH. DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes & Development. 12: 2598-609. PMID 9716411  0.96
1998 de Laat WL, Appeldoorn E, Jaspers NG, Hoeijmakers JH. DNA structural elements required for ERCC1-XPF endonuclease activity. The Journal of Biological Chemistry. 273: 7835-42. PMID 9525876 DOI: 10.1074/jbc.273.14.7835  0.96
1997 van Leeuwen HC, Strating MJ, Rensen M, de Laat W, van der Vliet PC. Linker length and composition influence the flexibility of Oct-1 DNA binding. The Embo Journal. 16: 2043-53. PMID 9155030 DOI: 10.1093/emboj/16.8.2043  0.96
1997 Vermeulen W, De Boer J, Citterio E, Van Gool AJ, Van Der Horst GTJ, Jaspers NGJ, De Laat WL, Sijbers AM, Van Der Spek PJ, Sugasawa K, Weeda G, Winkler GS, Bootsma D, Eglyt JM, Hoeijmakers JHJ. Mammalian nucleotide excision repair and syndromes Biochemical Society Transactions. 25: 309-315. PMID 9056889  0.96
1996 Sijbers AM, de Laat WL, Ariza RR, Biggerstaff M, Wei YF, Moggs JG, Carter KC, Shell BK, Evans E, de Jong MC, Rademakers S, de Rooij J, Jaspers NG, Hoeijmakers JH, Wood RD. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell. 86: 811-22. PMID 8797827 DOI: 10.1016/S0092-8674(00)80155-5  0.96
1995 Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC, Kaptein R. Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics. Journal of Biomolecular Nmr. 6: 23-32. PMID 7663141 DOI: 10.1007/BF00417488  0.96
1992 Medema RH, de Laat WL, Martin GA, McCormick F, Bos JL. GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Molecular and Cellular Biology. 12: 3425-30. PMID 1321335 DOI: 10.1128/MCB.12.8.3425  0.96
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