Valentin K. Gribkoff - Publications

Affiliations: 
Knopp Neurosciences Inc., Pittsburgh, PA, United States 

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2011 Sacchetti S, Dworetzky SI, Alavian KN, Zhang P, Bonanni L, Signore A, Mangold J, DeMarco U, Smith PJ, Gribkoff VK, Jonas EA. Decrease in a Leak Conductance Associated with Mitochondrial Complex V and Improved Bioenergetic Efficiency may Underlie Cytoprotection of at-Risk Neurons by Dexpramipexole Biophysical Journal. 100: 459a. DOI: 10.1016/J.Bpj.2010.12.2701  0.319
2007 Romine JL, Martin SW, Meanwell NA, Gribkoff VK, Boissard CG, Dworetzky SI, Natale J, Moon S, Ortiz A, Yeleswaram S, Pajor L, Gao Q, Starrett JE. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. Journal of Medicinal Chemistry. 50: 528-42. PMID 17266205 DOI: 10.1021/Jm061006N  0.305
2006 Lindner MD, Hogan JB, Hodges DB, Orie AF, Chen P, Corsa JA, Leet JE, Gillman KW, Rose GM, Jones KM, Gribkoff VK. Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping. Psychopharmacology. 188: 629-40. PMID 17004085 DOI: 10.1007/s00213-006-0556-3  0.687
2006 Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK. Pharmacological activation and inhibition of Slack (Slo2.2) channels. Neuropharmacology. 51: 896-906. PMID 16876206 DOI: 10.1016/J.Neuropharm.2006.06.003  0.327
2006 Lindner MD, Hogan JB, Krause RG, Machet F, Bourin C, Hodges DB, Corsa JA, Barten DM, Toyn JH, Stock DA, Rose GM, Gribkoff VK. Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice. Behavioural Brain Research. 173: 62-75. PMID 16828889 DOI: 10.1016/j.bbr.2006.06.003  0.671
2005 Vrudhula VM, Dasgupta B, Boissard CG, Gribkoff VK, Santone KS, Dalterio RA, Lodge NJ, Starrett JE. Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes. Bioorganic & Medicinal Chemistry Letters. 15: 4286-90. PMID 16061379 DOI: 10.1016/j.bmcl.2005.06.056  0.306
2005 Gribkoff VK, Winquist RJ. Voltage-gated cation channel modulators for the treatment of stroke. Expert Opinion On Investigational Drugs. 14: 579-92. PMID 15926865 DOI: 10.1517/13543784.14.5.579  0.314
2004 Boy KM, Guernon JM, Sit SY, Xie K, Hewawasam P, Boissard CG, Dworetzky SI, Natale J, Gribkoff VK, Lodge N, Starrett JE. 3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction. Bioorganic & Medicinal Chemistry Letters. 14: 5089-93. PMID 15380205 DOI: 10.1016/J.Bmcl.2004.07.080  0.302
2004 Wu YJ, He H, Sun LQ, L'Heureux A, Chen J, Dextraze P, Starrett JE, Boissard CG, Gribkoff VK, Natale J, Dworetzky SI. Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers. Journal of Medicinal Chemistry. 47: 2887-96. PMID 15139767 DOI: 10.1021/Jm0305826  0.305
2004 Wu YJ, Boissard CG, Chen J, Fitzpatrick W, Gao Q, Gribkoff VK, Harden DG, He H, Knox RJ, Natale J, Pieschl RL, Starrett JE, Sun LQ, Thompson M, Weaver D, et al. (S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons. Bioorganic & Medicinal Chemistry Letters. 14: 1991-5. PMID 15050644 DOI: 10.1016/J.Bmcl.2004.01.069  0.342
2003 Lindner MD, Gribkoff VK, Donlan NA, Jones TA. Long-lasting functional disabilities in middle-aged rats with small cerebral infarcts. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10913-22. PMID 14645487  0.609
2003 Gribkoff VK. The therapeutic potential of neuronal KCNQ channel modulators. Expert Opinion On Therapeutic Targets. 7: 737-48. PMID 14640909 DOI: 10.1517/14728222.7.6.737  0.322
2003 Lindner MD, Hodges DB, Hogan JB, Orie AF, Corsa JA, Barten DM, Polson C, Robertson BJ, Guss VL, Gillman KW, Starrett JE, Gribkoff VK. An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. The Journal of Pharmacology and Experimental Therapeutics. 307: 682-91. PMID 12975483 DOI: 10.1124/jpet.103.056002  0.635
2003 Wu YJ, Boissard CG, Greco C, Gribkoff VK, Harden DG, He H, L'Heureux A, Kang SH, Kinney GG, Knox RJ, Natale J, Newton AE, Lehtinen-Oboma S, Sinz MW, Sivarao DV, et al. (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. Journal of Medicinal Chemistry. 46: 3197-200. PMID 12852750 DOI: 10.1021/Jm034073F  0.306
2003 Gribkoff VK, Pieschl RL, Dudek FE. GABA receptor-mediated inhibition of neuronal activity in rat SCN in vitro: pharmacology and influence of circadian phase. Journal of Neurophysiology. 90: 1438-48. PMID 12750413 DOI: 10.1152/jn.01082.2002  0.545
2002 Hewawasam P, Fan W, Knipe J, Moon SL, Boissard CG, Gribkoff VK, Starrett JE. The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection. Bioorganic & Medicinal Chemistry Letters. 12: 1779-83. PMID 12067560 DOI: 10.1016/S0960-894X(02)00240-8  0.303
2002 Hewawasam P, Erway M, Thalody G, Weiner H, Boissard CG, Gribkoff VK, Meanwell NA, Lodge N, Starrett JE. The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence. Bioorganic & Medicinal Chemistry Letters. 12: 1117-20. PMID 11909730 DOI: 10.1016/S0960-894X(02)00099-9  0.316
2002 Hewawasam P, Gribkoff VK, Pendri Y, Dworetzky SI, Meanwell NA, Martinez E, Boissard CG, Post-Munson DJ, Trojnacki JT, Yeleswaram K, Pajor LM, Knipe J, Gao Q, Perrone R, Starrett JE. The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels. Bioorganic & Medicinal Chemistry Letters. 12: 1023-6. PMID 11909708 DOI: 10.1016/S0960-894X(02)00101-4  0.303
2002 Hewawasam P, Erway M, Moon SL, Knipe J, Weiner H, Boissard CG, Post-Munson DJ, Gao Q, Huang S, Gribkoff VK, Meanwell NA. Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties. Journal of Medicinal Chemistry. 45: 1487-99. PMID 11906290 DOI: 10.1021/Jm0101850  0.335
2002 Kiesewetter DO, Jagoda EM, Starrett JE, Gribkoff VK, Hewawasam P, Srinivas N, Salazar D, Eckelman WC. Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener. Nuclear Medicine and Biology. 29: 55-9. PMID 11786276 DOI: 10.1016/S0969-8051(01)00281-5  0.337
2001 Gribkoff VK, Starrett JE, Dworetzky SI. Maxi-K potassium channels: form, function, and modulation of a class of endogenous regulators of intracellular calcium. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 7: 166-77. PMID 11496927 DOI: 10.1177/107385840100700211  0.323
2001 Cheney JA, Weisser JD, Bareyre FM, Laurer HL, Saatman KE, Raghupathi R, Gribkoff V, Starrett JE, McIntosh TK. The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 21: 396-403. PMID 11323525 DOI: 10.1097/00004647-200104000-00008  0.34
2001 Gribkoff VK, Starrett JE, Dworetzky SI, Hewawasam P, Boissard CG, Cook DA, Frantz SW, Heman K, Hibbard JR, Huston K, Johnson G, Krishnan BS, Kinney GG, Lombardo LA, Meanwell NA, et al. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nature Medicine. 7: 471-7. PMID 11283675 DOI: 10.1038/86546  0.315
2000 Kinney GG, Taber MT, Gribkoff VK. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency? Molecular Neurobiology. 21: 137-52. PMID 11379796 DOI: 10.1385/MN:21:3:137  0.319
2000 Taber MT, Kinney GG, Pieschl RL, Yocca FD, Gribkoff VK. Differential effects of coadministration of fluoxetine and WAY-100635 on serotonergic neurotransmission in vivo: sensitivity to sequence of injections. Synapse (New York, N.Y.). 38: 17-26. PMID 10941137 DOI: 10.1002/1098-2396(200010)38:1<17::AID-SYN3>3.0.CO;2-5  0.332
1999 Gribkoff VK, Pieschl RL, Wisialowski TA, Park WK, Strecker GJ, de Jeu MT, Pennartz CM, Dudek FE. A reexamination of the role of GABA in the mammalian suprachiasmatic nucleus. Journal of Biological Rhythms. 14: 126-30. PMID 10194649 DOI: 10.1177/074873099129000515  0.511
1998 Gribkoff VK, Pieschl RL, Wisialowski TA, van den Pol AN, Yocca FD. Phase shifting of circadian rhythms and depression of neuronal activity in the rat suprachiasmatic nucleus by neuropeptide Y: mediation by different receptor subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3014-22. PMID 9526018 DOI: 10.1523/Jneurosci.18-08-03014.1998  0.319
1997 Gribkoff VK, Starrett JE, Dworetzky SI. The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels. Advances in Pharmacology (San Diego, Calif.). 37: 319-48. PMID 8891106 DOI: 10.1016/S1054-3589(08)60954-0  0.303
1996 Dworetzky SI, Boissard CG, Lum-Ragan JT, McKay MC, Post-Munson DJ, Trojnacki JT, Chang CP, Gribkoff VK. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4543-50. PMID 8764643 DOI: 10.1523/Jneurosci.16-15-04543.1996  0.301
1996 Meanwell NA, Sit SY, Gao J, Boissard CG, Lum-Ragan J, Dworetzky SI, Gribkoff VK. N-Benzylated benzimidazol-2-one derivatives: Activators of large-conductance Ca2+-dependent K+ channels Bioorganic and Medicinal Chemistry Letters. 6: 1641-1646. DOI: 10.1016/0960-894X(96)00296-X  0.3
1994 McKay MC, Dworetzky SI, Meanwell NA, Olesen SP, Reinhart PH, Levitan IB, Adelman JP, Gribkoff VK. Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004. Journal of Neurophysiology. 71: 1873-82. PMID 8064354 DOI: 10.1152/Jn.1994.71.5.1873  0.324
1994 Dworetzky SI, Trojnacki JT, Gribkoff VK. Cloning and expression of a human large-conductance calcium-activated potassium channel. Brain Research. Molecular Brain Research. 27: 189-93. PMID 7877450 DOI: 10.1016/0169-328X(94)90203-8  0.302
1994 Post-Munson DJ, Lum-Ragan JT, Mahle CD, Gribkoff VK. Reduced bicuculline response and GABAA agonist binding in aged rat hippocampus. Neurobiology of Aging. 15: 629-33. PMID 7824055 DOI: 10.1016/0197-4580(94)00057-3  0.349
1993 Boissard CG, Gribkoff VK. The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro. Neuropharmacology. 32: 149-55. PMID 8383814 DOI: 10.1016/0028-3908(93)90095-K  0.385
1992 Boissard CG, Lindner MD, Gribkoff VK. Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist: an anatomical and behavioral study. Neuroscience. 48: 807-12. PMID 1630626 DOI: 10.1016/0306-4522(92)90268-7  0.671
1992 Lindner MD, Gribkoff VK. Effects of oral BMY 21502 on Morris water task performance in 16-18 month old F-344 rats. Psychopharmacology. 107: 485-8. PMID 1603891 DOI: 10.1007/BF02245260  0.641
1992 Gribkoff VK, Bauman LA. Endogenous adenosine contributes to hypoxic synaptic depression in hippocampus from young and aged rats. Journal of Neurophysiology. 68: 620-8. PMID 1527579 DOI: 10.1152/Jn.1992.68.2.620  0.344
1992 Bauman LA, Mahle CD, Boissard CG, Gribkoff VK. Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices. Journal of Neurophysiology. 68: 629-38. PMID 1388201 DOI: 10.1152/Jn.1992.68.2.629  0.368
1991 Lindner MD, Gribkoff VK. Relationship between performance in the Morris water task, visual acuity, and thermoregulatory function in aged F-344 rats. Behavioural Brain Research. 45: 45-55. PMID 1764204 DOI: 10.1016/S0166-4328(05)80179-2  0.625
1991 Gribkoff VK. Electrophysiological evidence for N-methyl-D-aspartate excitatory amino acid receptors in the rat supraoptic nucleus in vitro. Neuroscience Letters. 131: 260-2. PMID 1684841 DOI: 10.1016/0304-3940(91)90628-7  0.336
1990 Gribkoff VK, Bauman LA, VanderMaelen CP. The adenosine antagonist 8-cyclopentyltheophylline reduces the depression of hippocampal neuronal responses during hypoxia. Brain Research. 512: 353-7. PMID 2354368 DOI: 10.1016/0006-8993(90)90648-U  0.335
1990 Gribkoff VK, Dudek FE. Effects of excitatory amino acid antagonists on synaptic responses of supraoptic neurons in slices of rat hypothalamus. Journal of Neurophysiology. 63: 60-71. PMID 2299386 DOI: 10.1152/Jn.1990.63.1.60  0.565
1990 Gribkoff VK, Bauman LA, VanderMaelen CP. A 1-heteroaryl-4-piperidinyl-methyl pyrrolidinone, BMY 21502, delays the decay of hippocampal synaptic potentiation in vitro. Neuropharmacology. 29: 1001-9. PMID 2087253 DOI: 10.1016/0028-3908(90)90105-Z  0.354
1988 Gribkoff VK, Christian EP, Robinson JH, Deadwyler SA, Dudek FE. Cholinergic excitation of supraoptic neurons in hypothalamic slices of rat. Neuropharmacology. 27: 721-7. PMID 3419551 DOI: 10.1016/0028-3908(88)90081-0  0.637
1988 Gribkoff VK, Dudek FE. The effects of the excitatory amino acid antagonist kynurenic acid on synaptic transmission to supraoptic neuroendocrine cells. Brain Research. 442: 152-6. PMID 2834012 DOI: 10.1016/0006-8993(88)91443-6  0.536
1988 Dudek FE, Gribkoff VK, Olson JE, Hertzberg EL. Reduction of dye coupling in glial cultures by microinjection of antibodies against the liver gap junction polypeptide. Brain Research. 439: 275-80. PMID 2833985 DOI: 10.1016/0006-8993(88)91484-9  0.473
1987 Dudek FE, Gribkoff VK. Synaptic activation of slow depolarization in rat supraoptic nucleus neurones in vitro. The Journal of Physiology. 387: 273-96. PMID 3656173  0.487
1982 Lee K, Schubert P, Gribkoff V, Sherman B, Lynch G. A combined in vivo/in vitro study of the presynaptic release of adenosine derivatives in the hippocampus Journal of Neurochemistry. 38: 80-83. PMID 7108536 DOI: 10.1111/j.1471-4159.1982.tb10856.x  0.419
1977 Lynch GS, Dunwiddie T, Gribkoff V. Heterosynaptic depression: a postsynaptic correlate of long term potentiation Nature. 266: 737-739. PMID 195211  0.471
1976 Deadwyler SA, Gribkoff V, Cotman C, Lynch G. Long lasting changes in the spontaneous activity of hippocampal neurons following stimulation of the entorhinal cortex. Brain Research Bulletin. 1: 1-7. PMID 974790 DOI: 10.1016/0361-9230(76)90043-5  0.591
1976 Lynch GS, Gribkoff VK, Deadwyler SA. Long term potentiation is accompanied by a reduction in dendritic responsiveness to glutamic acid. Nature. 263: 151-3. PMID 967251 DOI: 10.1038/263151a0  0.453
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