| Year |
Citation |
Score |
| 2023 |
Abeyawardhane DL, Adipietro KA, Godoy-Ruiz R, Varney KM, Sevdalis SE, Nawaz IF, Spittel AX, Rustandi RR, Silin VI, des Georges A, Pozharski E, Weber DJ. Endosomal activation of the binary toxin is Ca -dependent. Biorxiv : the Preprint Server For Biology. PMID 37645845 DOI: 10.1101/2023.08.18.553786 |
0.828 |
|
| 2023 |
Pidugu LS, Servius HW, Sevdalis SE, Cook ME, Varney KM, Pozharski E, Drohat AC. Characterizing inhibitors of human AP endonuclease 1. Plos One. 18: e0280526. PMID 36652434 DOI: 10.1371/journal.pone.0280526 |
0.664 |
|
| 2022 |
Coburn KM, Roth B, Varney KM, Carrier F, Weber DJ. H, C, and N assignments of the mRNA binding protein hnRNP A18. Biomolecular Nmr Assignments. PMID 36539586 DOI: 10.1007/s12104-022-10117-z |
0.764 |
|
| 2022 |
Young BD, Cook ME, Costabile BK, Samanta R, Zhuang X, Sevdalis SE, Varney KM, Mancia F, Matysiak S, Lattman E, Weber DJ. Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery. Journal of Molecular Biology. 167872. PMID 36354074 DOI: 10.1016/j.jmb.2022.167872 |
0.609 |
|
| 2021 |
Young BD, Varney KM, Wilder PT, Costabile BK, Pozharski E, Cook ME, Godoy-Ruiz R, Clarke OB, Mancia F, Weber DJ. Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6. Journal of Molecular Biology. 433: 167272. PMID 34592217 DOI: 10.1016/j.jmb.2021.167272 |
0.752 |
|
| 2021 |
Roth BM, DePalma RM, Cook ME, Varney KM, Weber DJ, Ogretmen B. H, C, and N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23-225). Biomolecular Nmr Assignments. PMID 34156643 DOI: 10.1007/s12104-021-10034-7 |
0.776 |
|
| 2021 |
Abeyawardhane DL, Godoy-Ruiz R, Adipietro KA, Varney KM, Rustandi RR, Pozharski E, Weber DJ. The Importance of Therapeutically Targeting the Binary Toxin from . International Journal of Molecular Sciences. 22. PMID 33805767 DOI: 10.3390/ijms22062926 |
0.767 |
|
| 2021 |
Young BD, Yu W, Rodríguez DJV, Varney KM, MacKerell AD, Weber DJ. Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS). Molecules (Basel, Switzerland). 26. PMID 33450915 DOI: 10.3390/molecules26020381 |
0.57 |
|
| 2020 |
Cook ME, Varney KM, Godoy-Ruiz R, Weber DJ. H, C, and N resonance assignments of the Clostridioides difficile receptor binding domain 2 (CDTb, residues 757-876). Biomolecular Nmr Assignments. PMID 33034833 DOI: 10.1007/s12104-020-09979-y |
0.507 |
|
| 2020 |
Varney KM, Wilder PT, Godoy-Ruiz R, Mancia F, Weber DJ. Correction to: H, C, and N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2). Biomolecular Nmr Assignments. PMID 32248334 DOI: 10.1007/s12104-020-09942-x |
0.634 |
|
| 2020 |
Xu X, Godoy-Ruiz R, Adipietro KA, Peralta C, Ben-Hail D, Varney KM, Cook ME, Roth BM, Wilder PT, Cleveland T, Grishaev A, Neu HM, Michel SLJ, Yu W, Beckett D, et al. Structure of the cell-binding component of the binary toxin reveals a di-heptamer macromolecular assembly. Proceedings of the National Academy of Sciences of the United States of America. PMID 31896582 DOI: 10.1073/Pnas.1919490117 |
0.812 |
|
| 2020 |
Coburn K, Solano-Gonzalez E, Roth B, Wilder PT, Varney K, Carrier F, Weber DJ. Investigation of the Impact of Post-Translational Modifications of HNRNP A18 on Small Molecule Inhibitors Biophysical Journal. 118: 49a. DOI: 10.1016/J.Bpj.2019.11.450 |
0.759 |
|
| 2019 |
Varney KM, Cook ME, Weber DJ. An asymmetry that leads to activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31427532 DOI: 10.1073/Pnas.1912729116 |
0.431 |
|
| 2019 |
Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder. Proceedings of the National Academy of Sciences of the United States of America. PMID 31399543 DOI: 10.1073/Pnas.1905516116 |
0.715 |
|
| 2019 |
Roth BM, Varney KM, Yang H, Weber DJ, Tomkinson AE. H, C, and N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (residues 257-477). Biomolecular Nmr Assignments. PMID 31093909 DOI: 10.1007/S12104-019-09896-9 |
0.76 |
|
| 2019 |
Varney KM, Wilder PT, Godoy-Ruiz R, Mancia F, Weber DJ. HC, and N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2). Biomolecular Nmr Assignments. PMID 30875027 DOI: 10.1007/S12104-019-09890-1 |
0.743 |
|
| 2019 |
Wilder PT, Varney KM, Weber DJ. Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 1929: 291-310. PMID 30710281 DOI: 10.1007/978-1-4939-9030-6_19 |
0.708 |
|
| 2019 |
Cook M, Varney K, Godoy-Ruiz R, Weber D. 1H 15N 13C Resonance Assignments of Receptor Binding Domain 1 of CDTb Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr28050 |
0.502 |
|
| 2019 |
Yu W, Pozharskiy E, Varney K, Weber DJ, MacKerell AD. Development of Small Molecule Inhibitors Targeting Clostridium Difficile Binary Toxin using the Site-Identification by Ligand Competitive Saturation (SILCS) Method Biophysical Journal. 116: 482a. DOI: 10.1016/J.Bpj.2018.11.2604 |
0.488 |
|
| 2018 |
He W, Mazzuca P, Yuan W, Varney K, Bugatti A, Cagnotto A, Giagulli C, Rusnati M, Marsico S, Diomede L, Salmona M, Caruso A, Lu W, Caccuri F. Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants. Biochimica Et Biophysica Acta. General Subjects. PMID 30248376 DOI: 10.1016/J.Bbagen.2018.09.016 |
0.305 |
|
| 2018 |
Hernández-Ochoa EO, Melville Z, Vanegas C, Varney KM, Wilder PT, Melzer W, Weber DJ, Schneider MF. Loss of S100A1 expression leads to Ca release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1. Physiological Reports. 6: e13822. PMID 30101473 DOI: 10.14814/Phy2.13822 |
0.834 |
|
| 2018 |
Conlon IL, Van Eker D, Abdelmalak S, Murphy WA, Bashir H, Sun M, Chauhan J, Varney KM, Godoy-Ruiz R, Wilder PT, Fletcher S. Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29705141 DOI: 10.1016/J.Bmcl.2018.03.050 |
0.622 |
|
| 2017 |
Giagulli C, D'Ursi P, He W, Zorzan S, Caccuri F, Varney K, Orro A, Marsico S, Otjacques B, Laudanna C, Milanesi L, Dolcetti R, Fiorentini S, Lu W, Caruso A. A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17. Scientific Reports. 7: 6555. PMID 28747658 DOI: 10.1038/S41598-017-06848-Y |
0.306 |
|
| 2017 |
Melville Z, Hernandez-Ochoa EO, Pratt SJ, Liu Y, Pierce AD, Wilder PT, Adipietro KA, Breysse DH, Varney K, Schneider MF, Weber DJ. The activation of PKA by the calcium-binding protein S100A1 is independent of cyclic AMP. Biochemistry. PMID 28409622 DOI: 10.1021/Acs.Biochem.7B00117 |
0.824 |
|
| 2017 |
Coburn K, Melville Z, Aligholizadeh E, Roth BM, Varney KM, Carrier F, Pozharski E, Weber DJ. Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif. Acta Crystallographica. Section F, Structural Biology Communications. 73: 209-214. PMID 28368279 DOI: 10.1107/S2053230X17003454 |
0.777 |
|
| 2016 |
Coey CT, Malik SS, Pidugu LS, Varney KM, Pozharski E, Drohat AC. Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Research. PMID 27580719 DOI: 10.1093/Nar/Gkw768 |
0.659 |
|
| 2016 |
Roth BM, Varney KM, Rustandi RR, Weber DJ. (1)H(N), (13)C, and (15)N resonance assignments of the CDTb-interacting domain (CDTaBID) from the Clostridium difficile binary toxin catalytic component (CDTa, residues 1-221). Biomolecular Nmr Assignments. PMID 27351891 DOI: 10.1007/S12104-016-9695-6 |
0.791 |
|
| 2016 |
Roth BM, Godoy-Ruiz R, Varney KM, Rustandi RR, Weber DJ. (1)H, (13)C, and (15)N resonance assignments of an enzymatically active domain from the catalytic component (CDTa, residues 216-420) of a binary toxin from Clostridium difficile. Biomolecular Nmr Assignments. PMID 26886352 DOI: 10.1007/S12104-016-9669-8 |
0.792 |
|
| 2016 |
Cavalier MC, Ansari MI, Pierce AD, Wilder PT, McKnight LE, Raman EP, Neau DB, Bezawada P, Alasady MJ, Charpentier TH, Varney K, Toth EA, MacKerell AD, Coop A, Weber DJ. Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. Journal of Medicinal Chemistry. PMID 26727270 DOI: 10.1021/Acs.Jmedchem.5B01369 |
0.793 |
|
| 2015 |
Malik SS, Coey CT, Varney KM, Pozharski E, Drohat AC. Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Research. 43: 9541-52. PMID 26358812 DOI: 10.1093/Nar/Gkv890 |
0.669 |
|
| 2015 |
Malik SS, Varney KM, Pozharski E, Drohat AC. Characterizing the enzyme-product complexes of thymine DNA glycosylase using crystallography and NMR Nucleic Acids Research. DOI: 10.2210/Pdb5Cys/Pdb |
0.63 |
|
| 2015 |
Melville Z, Varney K, Cavalier M, Stowe S, Weber D, Toth E, Weber D. Characterizing a New Metal Binding Site in S100B Biophysical Journal. 108: 48a. DOI: 10.1016/J.Bpj.2014.11.293 |
0.817 |
|
| 2015 |
Stowe SD, Cavalier MC, Godoy-Ruiz R, Varney KM, Wilder PT, Gartenhaus RB, Weber DJ. Characterizing the MCT-1:DenR Complex, a Translational Enhancer for Lymphoma Survival Biophysical Journal. 108: 219a. DOI: 10.1016/J.Bpj.2014.11.1212 |
0.777 |
|
| 2014 |
Tucker AT, Bobay BG, Banse AV, Olson AL, Soderblom EJ, Moseley MA, Thompson RJ, Varney KM, Losick R, Cavanagh J. A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. Journal of Molecular Biology. 426: 1911-24. PMID 24534728 DOI: 10.1016/J.Jmb.2014.02.010 |
0.398 |
|
| 2013 |
Ramagopal UA, Dulyaninova NG, Varney KM, Wilder PT, Nallamsetty S, Brenowitz M, Weber DJ, Almo SC, Bresnick AR. Structure of the S100A4/myosin-IIA complex. Bmc Structural Biology. 13: 31. PMID 24252706 DOI: 10.1186/1472-6807-13-31 |
0.751 |
|
| 2013 |
Varney KM, Bonvin AM, Pazgier M, Malin J, Yu W, Ateh E, Oashi T, Lu W, Huang J, Diepeveen-de Buin M, Bryant J, Breukink E, Mackerell AD, de Leeuw EP. Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II. Plos Pathogens. 9: e1003732. PMID 24244161 DOI: 10.1371/Journal.Ppat.1003732 |
0.303 |
|
| 2012 |
Bobay BG, Stewart AL, Tucker AT, Thompson RJ, Varney KM, Cavanagh J. Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3. Febs Letters. 586: 3582-9. PMID 22982862 DOI: 10.1016/J.Febslet.2012.08.032 |
0.477 |
|
| 2012 |
Liriano MA, Varney KM, Wright NT, Hoffman CL, Toth EA, Ishima R, Weber DJ. Target binding to S100B reduces dynamic properties and increases Ca(2+)-binding affinity for wild type and EF-hand mutant proteins. Journal of Molecular Biology. 423: 365-85. PMID 22824086 DOI: 10.1016/J.Jmb.2012.07.011 |
0.815 |
|
| 2012 |
Zhan C, Varney K, Yuan W, Zhao L, Lu W. Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined. Journal of the American Chemical Society. 134: 6855-64. PMID 22444248 DOI: 10.1021/Ja301255N |
0.375 |
|
| 2011 |
Yang Y, Berry AA, Lee WC, Garnett JA, Marchant J, Levine JA, Simpson PJ, Fogel SA, Varney KM, Matthews SJ, Nataro JP, Inman KG. Complete 1H, 13C and 15N NMR assignments for donor-strand complemented AafA, the major pilin of aggregative adherence fimbriae (AAF/II) from enteroaggregative E. coli. Biomolecular Nmr Assignments. 5: 1-5. PMID 20814767 DOI: 10.1007/S12104-010-9252-7 |
0.751 |
|
| 2011 |
Liriano M, Varney KM, Ishima R, Weber DJ. Abstract 2328: 15N-backbone and side-chain dynamics of the mutant calcium-binding protein S100B D63N Cancer Research. 71: 2328-2328. DOI: 10.1158/1538-7445.Am2011-2328 |
0.585 |
|
| 2011 |
Cannon B, Hernández-Ochoa E, Varney K, Schneider M, Weber D. The Interaction of S100a1 with Type-2b Regulatory Subunit of Protein Kinase A Biophysical Journal. 100: 86a. DOI: 10.1016/J.Bpj.2010.12.675 |
0.733 |
|
| 2010 |
Wilder PT, Charpentier TH, Liriano MA, Gianni K, Varney KM, Pozharski E, Coop A, Toth EA, Mackerell AD, Weber DJ. In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction. International Journal of High Throughput Screening. 2010: 109-126. PMID 21132089 DOI: 10.2147/IJHTS.S8210 |
0.789 |
|
| 2010 |
Malashkevich VN, Dulyaninova NG, Ramagopal UA, Liriano MA, Varney KM, Knight D, Brenowitz M, Weber DJ, Almo SC, Bresnick AR. Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 107: 8605-10. PMID 20421509 DOI: 10.1073/Pnas.0913660107 |
0.85 |
|
| 2010 |
Charpentier TH, Thompson LE, Liriano MA, Varney KM, Wilder PT, Pozharski E, Toth EA, Weber DJ. The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. Journal of Molecular Biology. 396: 1227-43. PMID 20053360 DOI: 10.1016/J.Jmb.2009.12.057 |
0.835 |
|
| 2010 |
Manvilla BA, Varney KM, Drohat AC. Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1. Biomolecular Nmr Assignments. 4: 5-8. PMID 19888678 DOI: 10.1007/S12104-009-9196-Y |
0.653 |
|
| 2009 |
Bai G, Feng B, Wang JB, Varney KM, Shapiro M. Backbone assignment of HINT1 protein, a mouse histidine triad nucleotide binding protein. Biomolecular Nmr Assignments. 3: 57-9. PMID 19636947 DOI: 10.1007/S12104-008-9141-5 |
0.406 |
|
| 2009 |
Charpentier TH, Wilder PT, Liriano MA, Varney KM, Zhong S, Coop A, Pozharski E, MacKerell AD, Toth EA, Weber DJ. Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography. Biochemistry. 48: 6202-12. PMID 19469484 DOI: 10.1021/Bi9005754 |
0.832 |
|
| 2009 |
Wright NT, Cannon BR, Wilder PT, Morgan MT, Varney KM, Zimmer DB, Weber DJ. Solution structure of S100A1 bound to the CapZ peptide (TRTK12). Journal of Molecular Biology. 386: 1265-77. PMID 19452629 DOI: 10.1016/J.Jmb.2009.01.022 |
0.84 |
|
| 2009 |
Wright NT, Varney KM, Cannon BR, Morgan M, Weber DJ. Ca-S100A1 interacting with TRTK12 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kbm/Pdb |
0.706 |
|
| 2008 |
Wright NT, Inman KG, Levine JA, Cannon BR, Varney KM, Weber DJ. Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B. Journal of Biomolecular Nmr. 42: 279-86. PMID 18949447 DOI: 10.1007/S10858-008-9282-Y |
0.822 |
|
| 2008 |
Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. The Journal of Biological Chemistry. 283: 26676-83. PMID 18650434 DOI: 10.1074/Jbc.M804432200 |
0.762 |
|
| 2008 |
Charpentier TH, Wilder PT, Liriano MA, Varney KM, Pozharski E, MacKerell AD, Coop A, Toth EA, Weber DJ. Divalent metal ion complexes of S100B in the absence and presence of pentamidine. Journal of Molecular Biology. 382: 56-73. PMID 18602402 DOI: 10.1016/J.Jmb.2008.06.047 |
0.817 |
|
| 2008 |
Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR. Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry. 47: 5111-26. PMID 18410126 DOI: 10.1021/Bi702537S |
0.852 |
|
| 2008 |
Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF. S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling. The Journal of Biological Chemistry. 283: 5046-57. PMID 18089560 DOI: 10.1074/Jbc.M709231200 |
0.728 |
|
| 2008 |
Rifat D, Wright NT, Varney KM, Weber DJ, Black LW. Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target. Journal of Molecular Biology. 375: 720-34. PMID 18037438 DOI: 10.1016/J.Jmb.2007.10.064 |
0.663 |
|
| 2007 |
Velarde JJ, Varney KM, Inman KG, Farfan M, Dudley E, Fletcher J, Weber DJ, Nataro JP. Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli. Molecular Microbiology. 66: 1123-35. PMID 17986189 DOI: 10.1111/J.1365-2958.2007.05985.X |
0.757 |
|
| 2007 |
Charpentier TH, Wilder PT, Varney KM, Toth EA, Weber DJ. The 3D structures of Ca 2+ ‐S100B in Zn 2+ ‐ and pentamidine‐bound complexes as determined by X‐ray crystallography The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A630-A |
0.807 |
|
| 2006 |
Wilder PT, Lin J, Bair CL, Charpentier TH, Yang D, Liriano M, Varney KM, Lee A, Oppenheim AB, Adhya S, Carrier F, Weber DJ. Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Biochimica Et Biophysica Acta. 1763: 1284-97. PMID 17010455 DOI: 10.1016/J.Bbamcr.2006.08.024 |
0.79 |
|
| 2006 |
Garrett SC, Varney KM, Weber DJ, Bresnick AR. S100A4, a mediator of metastasis. The Journal of Biological Chemistry. 281: 677-80. PMID 16243835 DOI: 10.1074/Jbc.R500017200 |
0.398 |
|
| 2005 |
Wright NT, Varney KM, Ellis KC, Markowitz J, Gitti RK, Zimmer DB, Weber DJ. The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy. Journal of Molecular Biology. 353: 410-26. PMID 16169012 DOI: 10.1016/J.Jmb.2005.08.027 |
0.832 |
|
| 2005 |
Gitti RK, Wright NT, Margolis JW, Varney KM, Weber DJ, Margolis FL. Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements. Biochemistry. 44: 9673-9. PMID 16008352 DOI: 10.1021/Bi050149T |
0.641 |
|
| 2005 |
Markowitz J, Rustandi RR, Varney KM, Wilder PT, Udan R, Wu SL, Horrocks WD, Weber DJ. Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53. Biochemistry. 44: 7305-14. PMID 15882069 DOI: 10.1021/Bi050321T |
0.829 |
|
| 2005 |
Wilder PT, Varney KM, Weiss MB, Gitti RK, Weber DJ. Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy. Biochemistry. 44: 5690-702. PMID 15823027 DOI: 10.1021/Bi0475830 |
0.832 |
|
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