Tulin H. Dadali, Ph.D.

Affiliations: 
2014 School of Medicine and Dentistry University of Rochester, Rochester, NY 
Area:
Cell Biology, Biochemistry, Pathology
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Frances Lund grad student 2014 Rochester
 (The Role of CD38 in Regulating NAD Metabolism, Oxidative Stress Responses, and Activity of NAD-Consuming Enzymes.)
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Publications

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Dadali T, Diers AR, Kazerounian S, et al. (2021) Elevated levels of mitochondrial CoQ induce ROS-mediated apoptosis in pancreatic cancer. Scientific Reports. 11: 5749
Schultz MD, Dadali T, Jacques SA, et al. (2020) Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival. Plos Pathogens. 16: e1008539
Dadali T, Kulkarni S, Ng R, et al. (2018) Abstract 873: BPM 31510, a clinical stage metabolic modulator, demonstrates therapeutic efficacy in glioblastoma models of temozolomide chemo-sensitive and resistance by targeting mitochondrial function Cancer Research. 78: 873-873
Awate P, Dadali T, Ng R, et al. (2018) Abstract 3530: Coenzyme Q10 (BPM31510-IV in clinical trials) increases mitochondrial Q-pool and modulates electron transport chain function to elicit cell death in pancreatic cancer cells Cancer Research. 78: 3530-3530
Nagpal S, Dadali T, Jang T, et al. (2017) Effect of BPM31510 on radiosensitivity of temozolomide-resistant glioblastoma cell model and survival in in vivo C6 glioma rat model supporting phase I clinical investigation in GBM. Journal of Clinical Oncology. 35: e13509-e13509
Kazerounian S, Sarma A, Gaur N, et al. (2017) Abstract 5576: BPM 31510, a clinical stage candidate demonstrates potent anti-tumor effect in an immune-competent syngeneic pancreatic cancer model Cancer Research. 77: 5576-5576
Gesta S, Nagpal S, Dadali T, et al. (2017) Abstract 4067: BPM31510, a clinical stage metabolic modulator demonstrates therapeutic efficacy in anin vivoC6 rat glioma model and synergizes with temozolomide Cancer Research. 77: 4067-4067
Dadali T, Krumova K, Diers AR, et al. (2017) Abstract 1497: BPM31510 modulates mitochondrial complex activity to influence oxidative stress in effectuating cell death in multiple cancers Cancer Research. 77: 1497-1497
Botta D, Dadali T, Mousseau BJ, et al. (2016) Abstract LB-055: High-throughput screening efforts for the identification of selective and potent inhibitors of CD38 for the treatment of hematological cancers Cancer Research. 76
Dadali T, Diers AR, Ouro-Djobo R, et al. (2016) Abstract 212: BPM 31510 synergizes gemcitabine efficacy in pancreatic adenocarcinoma via mechanism independent of its anti-Warburg influence on metabolism Cancer Research. 76: 212-212
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