Jonathan A. Deane, Ph.D.
Affiliations: | 2005 | University of California, Irvine, Irvine, CA |
Area:
ImmunologyGoogle:
"Jonathan Deane"Parents
Sign in to add mentor| David A. Fruman | grad student | 2005 | UC Irvine | |
| (Genetic analysis of phosphoinositide 3 -kinase regulatory isoforms in immune function.) | ||||
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Publications
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| Alper PB, Deane J, Betschart C, et al. (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic & Medicinal Chemistry Letters. 30: 127366 |
| Annable T, Tomassian T, Jain S, et al. (2015) Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus. Autoimmunity. 48: 29-39 |
| Walsh ER, Pisitkun P, Voynova E, et al. (2012) Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 109: 16276-81 |
| Crampton SP, Deane JA, Feigenbaum L, et al. (2012) Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 188: 1451-9 |
| Oak JS, Chen J, Peralta RQ, et al. (2009) The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity. 42: 447-58 |
| Oak JS, Deane JA, Kharas MG, et al. (2009) Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) Proceedings of the National Academy of Sciences of the United States of America. 106: 10871 |
| Deane JA, Pisitkun P, Barrett RS, et al. (2007) Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity. 27: 801-10 |
| Matheu MP, Deane JA, Parker I, et al. (2007) Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. Journal of Immunology (Baltimore, Md. : 1950). 179: 2261-9 |
| Deane JA, Kharas MG, Oak JS, et al. (2007) T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 109: 2894-902 |
| Oak JS, Deane JA, Kharas MG, et al. (2006) Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16882-7 |