| Year |
Citation |
Score |
| 2024 |
Manning BD, Dibble CC. Growth Signaling Networks Orchestrate Cancer Metabolic Networks. Cold Spring Harbor Perspectives in Medicine. PMID 38438221 DOI: 10.1101/cshperspect.a041543 |
0.428 |
|
| 2022 |
Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nature Metabolism. 4: 1792-1811. PMID 36536136 DOI: 10.1038/s42255-022-00706-6 |
0.323 |
|
| 2022 |
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, ... ... Manning BD, et al. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 13: 2698. PMID 35577785 DOI: 10.1038/s41467-022-30362-z |
0.7 |
|
| 2021 |
Hosios AM, Manning BD. Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect. Cancer Research. 81: 4896-4898. PMID 34598998 DOI: 10.1158/0008-5472.CAN-21-2647 |
0.337 |
|
| 2021 |
Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Molecular Metabolism. 101309. PMID 34303878 DOI: 10.1016/j.molmet.2021.101309 |
0.686 |
|
| 2021 |
Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 10. PMID 33646118 DOI: 10.7554/eLife.63326 |
0.431 |
|
| 2020 |
Valvezan AJ, McNamara MC, Miller SK, Torrence ME, Asara JM, Henske EP, Manning BD. IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. Jci Insight. 5. PMID 32271165 DOI: 10.1172/Jci.Insight.135071 |
0.371 |
|
| 2019 |
Valvezan AJ, Manning BD. Molecular logic of mTORC1 signalling as a metabolic rheostat. Nature Metabolism. 1: 321-333. PMID 32694720 DOI: 10.1038/s42255-019-0038-7 |
0.409 |
|
| 2019 |
Hoxhaj G, Manning BD. The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nature Reviews. Cancer. PMID 31686003 DOI: 10.1038/S41568-019-0216-7 |
0.518 |
|
| 2019 |
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, ... Manning BD, et al. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nature Immunology. PMID 31636464 DOI: 10.1038/S41590-019-0515-X |
0.313 |
|
| 2019 |
Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP synthesis through Akt-mediated phosphorylation of NAD kinase. Science (New York, N.Y.). 363: 1088-1092. PMID 30846598 DOI: 10.1126/Science.Aau3903 |
0.708 |
|
| 2019 |
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Manning BD, et al. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. PMID 30783264 DOI: 10.1038/S41556-019-0280-Y |
0.419 |
|
| 2019 |
Manning BD. Signalling protein protects the heart muscle from pressure-related stress. Nature. 566: 187-188. PMID 30737501 DOI: 10.1038/D41586-019-00245-3 |
0.3 |
|
| 2019 |
Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nature Protocols. PMID 30683937 DOI: 10.1038/S41596-018-0102-X |
0.639 |
|
| 2018 |
Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, ... ... Manning BD, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and HS Production. Cell. 173: 117-129.e14. PMID 29570992 DOI: 10.1016/J.Cell.2018.03.001 |
0.64 |
|
| 2018 |
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, ... ... Manning BD, et al. Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. PMID 29342137 DOI: 10.1038/Nature25470 |
0.326 |
|
| 2017 |
Kelsey I, Zbinden M, Byles V, Torrence M, Manning BD. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci. Scientific Reports. 7: 16112. PMID 29170467 DOI: 10.1038/S41598-017-16398-Y |
0.476 |
|
| 2017 |
Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Reports. 21: 1331-1346. PMID 29091770 DOI: 10.1016/J.Celrep.2017.10.029 |
0.71 |
|
| 2017 |
Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. PMID 29056426 DOI: 10.1016/J.Ccell.2017.09.013 |
0.447 |
|
| 2017 |
Manning BD. Game of TOR - The Target of Rapamycin Rules Four Kingdoms. The New England Journal of Medicine. PMID 28874074 DOI: 10.1056/Nejmcibr1709384 |
0.355 |
|
| 2017 |
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, ... ... Manning BD, et al. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. PMID 28658205 DOI: 10.1038/Nature22964 |
0.454 |
|
| 2017 |
Manning BD, Toker A. AKT/PKB Signaling: Navigating the Network. Cell. 169: 381-405. PMID 28431241 DOI: 10.1016/J.Cell.2017.04.001 |
0.413 |
|
| 2017 |
Ben-Sahra I, Manning BD. mTORC1 signaling and the metabolic control of cell growth. Current Opinion in Cell Biology. 45: 72-82. PMID 28411448 DOI: 10.1016/J.Ceb.2017.02.012 |
0.741 |
|
| 2017 |
Belaid A, Filippakis H, Lam H, Valvezan A, Huang R, Xia M, Wen T, Baglini C, Sakamuru S, Asara J, Sinh NT, Heard JJ, Tamanoi F, Austin C, Manning B, et al. Abstract A09: Therapeutic targeting of TSC2-deficient cells with Methotrexate: Results of a drug repurposing screen Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A09 |
0.375 |
|
| 2016 |
Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metabolism. PMID 28089566 DOI: 10.1016/J.Cmet.2016.12.009 |
0.458 |
|
| 2016 |
Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. PMID 27919065 DOI: 10.1038/Nature20789 |
0.314 |
|
| 2016 |
Ilagan E, Manning BD. Emerging role of mTOR in the response to cancer therapeutics. Trends in Cancer. 2: 241-251. PMID 27668290 DOI: 10.1016/J.Trecan.2016.03.008 |
0.375 |
|
| 2016 |
Ricoult SJ, Dibble CC, Asara JM, Manning BD. SREBP regulates the expression and metabolic functions of wild-type and oncogenic IDH1. Molecular and Cellular Biology. PMID 27354064 DOI: 10.1128/Mcb.00163-16 |
0.419 |
|
| 2016 |
Hallett JE, Manning BD. CASTORing New Light on Amino Acid Sensing. Cell. 165: 15-7. PMID 27015302 DOI: 10.1016/J.Cell.2016.03.002 |
0.351 |
|
| 2016 |
Ben-Sahra I, Hoxhaj G, Ricoult SJ, Asara JM, Manning BD. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science (New York, N.Y.). 351: 728-33. PMID 26912861 DOI: 10.1126/Science.Aad0489 |
0.731 |
|
| 2016 |
Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 5. PMID 26894960 DOI: 10.7554/Elife.11612 |
0.708 |
|
| 2016 |
Zhang Y, Manning BD. Zhang & Manning reply. Nature. 529: E2-3. PMID 26791732 DOI: 10.1038/Nature16473 |
0.428 |
|
| 2016 |
Priolo C, Ricoult SJH, Khabibullin D, Filippakis H, Yu J, Manning B, Clish C, Henske EP. Abstract B06: TSC2 loss induces aberrant choline lysoglycerophospholipid metabolism Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B06 |
0.446 |
|
| 2015 |
Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Science Signaling. 8: rs9. PMID 26350902 DOI: 10.1126/Scisignal.Aab3729 |
0.422 |
|
| 2015 |
Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. PMID 26028026 DOI: 10.1038/Onc.2015.179 |
0.718 |
|
| 2015 |
Zhang Y, Manning BD. mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle (Georgetown, Tex.). 14: 2011-7. PMID 26017155 DOI: 10.1080/15384101.2015.1044188 |
0.476 |
|
| 2015 |
Priolo C, Ricoult SJ, Khabibullin D, Filippakis H, Yu J, Manning BD, Clish C, Henske EP. Tuberous Sclerosis Complex 2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology. 53: 33-41. PMID 25780943 DOI: 10.1165/Rcmb.2014-0379Rc |
0.438 |
|
| 2015 |
Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Author response: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation Elife. DOI: 10.7554/Elife.11612.024 |
0.697 |
|
| 2015 |
Manning BD. Abstract IA07: The TSC complex links PI3K to mTOR and cancer metabolism Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Ia07 |
0.571 |
|
| 2014 |
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, ... ... Manning BD, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nature Cell Biology. 16: 1069-79. PMID 25327288 DOI: 10.1038/Ncb3053 |
0.318 |
|
| 2014 |
Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes & Development. 28: 1917-28. PMID 25184678 DOI: 10.1101/Gad.245910.114 |
0.667 |
|
| 2014 |
Kwiatkowski DJ, Manning BD. Molecular basis of giant cells in tuberous sclerosis complex. The New England Journal of Medicine. 371: 778-80. PMID 25140966 DOI: 10.1056/Nejmcibr1406613 |
0.374 |
|
| 2014 |
Harputlugil E, Hine C, Vargas D, Robertson L, Manning BD, Mitchell JR. The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Reports. 8: 1160-70. PMID 25131199 DOI: 10.1016/J.Celrep.2014.07.018 |
0.332 |
|
| 2014 |
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 513: 440-3. PMID 25043031 DOI: 10.1038/Nature13492 |
0.452 |
|
| 2014 |
Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death and Differentiation. 21: 836-44. PMID 24583639 DOI: 10.1038/Cdd.2014.24 |
0.64 |
|
| 2014 |
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 156: 771-85. PMID 24529379 DOI: 10.1016/J.Cell.2013.11.049 |
0.453 |
|
| 2014 |
Ricoult S, Yecies J, Manning B. Oncogenic signaling upstream of mTORC1 drives lipogenesis and proliferation through SREBP Cancer and Metabolism. 2: 62. DOI: 10.1186/2049-3002-2-S1-P62 |
0.554 |
|
| 2014 |
Ben-Sahra I, Ricoult S, Howell J, Asara J, Manning B. mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms. Cancer and Metabolism. 2: 6. DOI: 10.1186/2049-3002-2-S1-P6 |
0.715 |
|
| 2014 |
Howell JJ, Hellberg K, Shaw RJ, Manning BD. Mechanisms and consequences of hepatic regulation of mTORC1 by metformin Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P28 |
0.504 |
|
| 2013 |
Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR pathway regulates macrophage polarization. Nature Communications. 4: 2834. PMID 24280772 DOI: 10.1038/Ncomms3834 |
0.688 |
|
| 2013 |
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Manning BD, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. 15: 1340-50. PMID 24161930 DOI: 10.1038/Ncb2860 |
0.491 |
|
| 2013 |
Kelsey I, Manning BD. mTORC1 status dictates tumor response to targeted therapeutics. Science Signaling. 6: pe31. PMID 24065143 DOI: 10.1126/Scisignal.2004632 |
0.452 |
|
| 2013 |
Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Science Signaling. 6: ra64. PMID 23901139 DOI: 10.1126/Scisignal.2004111 |
0.365 |
|
| 2013 |
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochemical Society Transactions. 41: 906-12. PMID 23863154 DOI: 10.1042/Bst20130041 |
0.737 |
|
| 2013 |
Menon S, Manning BD. Cell signalling: nutrient sensing lost in cancer. Nature. 498: 444-5. PMID 23803840 DOI: 10.1038/498444A |
0.379 |
|
| 2013 |
Manning BD. Adaptation to starvation: translating a matter of life or death. Cancer Cell. 23: 713-5. PMID 23763997 DOI: 10.1016/J.Ccr.2013.05.012 |
0.351 |
|
| 2013 |
Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nature Cell Biology. 15: 555-64. PMID 23728461 DOI: 10.1038/Ncb2763 |
0.516 |
|
| 2013 |
Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Manning BD, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.Cd-13-0015 |
0.47 |
|
| 2013 |
Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science (New York, N.Y.). 339: 1323-8. PMID 23429703 DOI: 10.1126/Science.1228792 |
0.733 |
|
| 2013 |
Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. Embo Reports. 14: 242-51. PMID 23399656 DOI: 10.1038/Embor.2013.5 |
0.487 |
|
| 2012 |
Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Molecular Cell. 47: 535-46. PMID 22795129 DOI: 10.1016/J.Molcel.2012.06.009 |
0.433 |
|
| 2012 |
Manning BD. Comment on "A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation": building a model of the mTOR signaling network with a potentially faulty tool. Science Signaling. 5: lc3; author reply lc. PMID 22786721 DOI: 10.1126/Scisignal.2003250 |
0.419 |
|
| 2012 |
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Science Signaling. 5: ra24. PMID 22457330 DOI: 10.1126/Scisignal.2002739 |
0.394 |
|
| 2012 |
Manning BD. Abstract PL03-01: The nutrient-sensing mTOR pathway in cancer initiation and progression Cancer Prevention Research. 5. DOI: 10.1158/1940-6207.Prev-12-Pl03-01 |
0.51 |
|
| 2012 |
Manning BD. Abstract SY29-02: The TSC-mTOR pathway and control of anabolic tumor cell metabolism Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy29-02 |
0.546 |
|
| 2011 |
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, ... ... Manning BD, et al. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discovery. 1: 524-38. PMID 22145100 DOI: 10.1158/2159-8290.Cd-11-0124 |
0.439 |
|
| 2011 |
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 20: 400-13. PMID 21907929 DOI: 10.1016/J.Ccr.2011.08.014 |
0.307 |
|
| 2011 |
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metabolism. 14: 21-32. PMID 21723501 DOI: 10.1016/J.Cmet.2011.06.002 |
0.419 |
|
| 2011 |
Yecies JL, Manning BD. Transcriptional control of cellular metabolism by mTOR signaling. Cancer Research. 71: 2815-20. PMID 21487041 DOI: 10.1158/0008-5472.Can-10-4158 |
0.522 |
|
| 2011 |
Yecies JL, Manning BD. mTOR links oncogenic signaling to tumor cell metabolism. Journal of Molecular Medicine (Berlin, Germany). 89: 221-8. PMID 21301797 DOI: 10.1007/S00109-011-0726-6 |
0.526 |
|
| 2011 |
Howell JJ, Manning BD. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends in Endocrinology and Metabolism: Tem. 22: 94-102. PMID 21269838 DOI: 10.1016/J.Tem.2010.12.003 |
0.435 |
|
| 2010 |
Manning BD. Insulin signaling: inositol phosphates get into the Akt. Cell. 143: 861-3. PMID 21145450 DOI: 10.1016/J.Cell.2010.11.040 |
0.321 |
|
| 2010 |
Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, ... Manning BD, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell. 39: 171-83. PMID 20670887 DOI: 10.1016/J.Molcel.2010.06.022 |
0.491 |
|
| 2010 |
Yecies JL, Manning BD. Chewing the fat on tumor cell metabolism. Cell. 140: 28-30. PMID 20085702 DOI: 10.1016/J.Cell.2009.12.037 |
0.397 |
|
| 2010 |
Dibble CC, Manning BD. The TSC1-TSC2 complex. A key signal-integrating node upstream of TOR Enzymes. 28: 21-48. DOI: 10.1016/S1874-6047(10)28002-2 |
0.489 |
|
| 2009 |
Dibble CC, Manning BD. A molecular link between AKT regulation and chemotherapeutic response. Cancer Cell. 16: 178-80. PMID 19732717 DOI: 10.1016/J.Ccr.2009.08.011 |
0.393 |
|
| 2009 |
Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Molecular and Cellular Biology. 29: 5657-70. PMID 19720745 DOI: 10.1128/Mcb.00735-09 |
0.434 |
|
| 2009 |
Huang J, Wu S, Wu CL, Manning BD. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Research. 69: 6107-14. PMID 19602587 DOI: 10.1158/0008-5472.Can-09-0975 |
0.475 |
|
| 2009 |
Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. Plos One. 4: e6189. PMID 19593385 DOI: 10.1371/Journal.Pone.0006189 |
0.486 |
|
| 2009 |
James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V. NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. Molecular and Cellular Biology. 29: 4250-61. PMID 19451225 DOI: 10.1128/Mcb.01581-08 |
0.456 |
|
| 2009 |
Manning BD. Challenges and opportunities in defining the essential cancer kinome. Science Signaling. 2: pe15. PMID 19318621 DOI: 10.1126/Scisignal.263Pe15 |
0.384 |
|
| 2009 |
Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochemical Society Transactions. 37: 217-22. PMID 19143635 DOI: 10.1042/Bst0370217 |
0.451 |
|
| 2009 |
Manning BD, VanHook AM. Science signaling podcast: 07 April 2009 Science Signaling. 2: pc7. DOI: 10.1126/Scisignal.265Pc7 |
0.379 |
|
| 2008 |
Menon S, Manning BD. Common corruption of the mTOR signaling network in human tumors. Oncogene. 27: S43-51. PMID 19956179 DOI: 10.1038/Onc.2009.352 |
0.474 |
|
| 2008 |
Chakrabarti P, Anno T, Manning BD, Luo Z, Kandror KV. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. Molecular Endocrinology (Baltimore, Md.). 22: 2260-7. PMID 18653778 DOI: 10.1210/Me.2008-0148 |
0.395 |
|
| 2008 |
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. The Biochemical Journal. 412: 179-90. PMID 18466115 DOI: 10.1042/Bj20080281 |
0.472 |
|
| 2008 |
Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Molecular and Cellular Biology. 28: 4104-15. PMID 18411301 DOI: 10.1128/Mcb.00289-08 |
0.454 |
|
| 2008 |
Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell. 29: 541-51. PMID 18342602 DOI: 10.1016/J.Molcel.2007.12.023 |
0.449 |
|
| 2007 |
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 129: 1261-74. PMID 17604717 DOI: 10.1016/J.Cell.2007.06.009 |
0.504 |
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| 2006 |
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Molecular Cell. 24: 185-97. PMID 17052453 DOI: 10.1016/J.Molcel.2006.09.019 |
0.488 |
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| 2006 |
Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 10: 133-43. PMID 16904612 DOI: 10.1016/J.Ccr.2006.05.026 |
0.4 |
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| 2005 |
Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Human Molecular Genetics. 14: R251-8. PMID 16244323 DOI: 10.1093/Hmg/Ddi260 |
0.525 |
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| 2005 |
Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes & Development. 19: 1773-8. PMID 16027169 DOI: 10.1101/Gad.1314605 |
0.394 |
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| 2004 |
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes & Development. 18: 2893-904. PMID 15545625 DOI: 10.1101/Gad.1256804 |
0.472 |
|
| 2004 |
Manning BD. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. The Journal of Cell Biology. 167: 399-403. PMID 15533996 DOI: 10.1083/Jcb.200408161 |
0.436 |
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| 2004 |
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/J.Ccr.2004.06.007 |
0.449 |
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| 2004 |
Manning BD. Correction: Balancing Akt with S6K Journal of Cell Biology. 167: 1255-1255. DOI: 10.1083/Jcb200408161113004C |
0.314 |
|
| 2003 |
Manning BD, Cantley LC. Rheb fills a GAP between TSC and TOR. Trends in Biochemical Sciences. 28: 573-6. PMID 14607085 DOI: 10.1016/J.Tibs.2003.09.003 |
0.402 |
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| 2003 |
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology : Cb. 13: 1259-68. PMID 12906785 DOI: 10.1016/S0960-9822(03)00506-2 |
0.425 |
|
| 2003 |
Manning BD, Cantley LC. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochemical Society Transactions. 31: 573-8. PMID 12773158 DOI: 10.1042/Bst0310573 |
0.489 |
|
| 2002 |
Manning BD, Cantley LC. Hitting the target: emerging technologies in the search for kinase substrates. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe49. PMID 12475999 DOI: 10.1126/Stke.2002.162.Pe49 |
0.34 |
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| 2002 |
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America. 99: 13571-6. PMID 12271141 DOI: 10.1073/Pnas.202476899 |
0.46 |
|
| 2002 |
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell. 10: 151-62. PMID 12150915 DOI: 10.1016/S1097-2765(02)00568-3 |
0.406 |
|
| 2000 |
Barrett JG, Manning BD, Snyder M. The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Molecular Biology of the Cell. 11: 2373-85. PMID 10888675 DOI: 10.1091/Mbc.11.7.2373 |
0.44 |
|
| 2000 |
Manning BD, Snyder M. Drivers and passengers wanted! the role of kinesin-associated proteins. Trends in Cell Biology. 10: 281-9. PMID 10856931 DOI: 10.1016/S0962-8924(00)01774-8 |
0.404 |
|
| 1999 |
Manning BD, Barrett JG, Wallace JA, Granok H, Snyder M. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. The Journal of Cell Biology. 144: 1219-33. PMID 10087265 DOI: 10.1083/Jcb.144.6.1219 |
0.489 |
|
| 1997 |
Manning BD, Padmanabha R, Snyder M. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Molecular Biology of the Cell. 8: 1829-44. PMID 9348527 DOI: 10.1091/Mbc.8.10.1829 |
0.449 |
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