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Gregory S. Ducker, Ph.D. - Publications

Affiliations: 
2013 Chemistry University of California, Berkeley, Berkeley, CA, United States 
Area:
signal transduction pathways in cells and whole organisms
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. Glycine homeostasis requires reverse SHMT flux. Cell Metabolism. 36: 103-115.e4. PMID 38171330 DOI: 10.1016/j.cmet.2023.12.001  0.472
2023 Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, et al. Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy. Molecular Cancer Therapeutics. OF1. PMID 36602953 DOI: 10.1158/1535-7163.MCT-22-0766  0.508
2020 Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, et al. Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. Elife. 9. PMID 32795388 DOI: 10.7554/Elife.52558  0.341
2020 García-Cañaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. PMID 32382081 DOI: 10.1038/S41375-020-0845-6  0.571
2020 Li AM, Ducker GS, Li Y, Seoane JA, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves EE, Rankin EB, Curtis C, Massague J, Rabinowitz JD, Thompson CB, et al. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular Cancer Research : McR. PMID 31941752 DOI: 10.1158/1541-7786.Mcr-19-0606  0.601
2020 Li AM, Ducker GS, Li Y, Seoane JA, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves EE, Rankin EB, Curtis C, Massague J, Rabinowitz JD, Thompson CB, et al. Abstract 5713: Reprogramming of serine metabolism during breast cancer progression Cancer Research. 80: 5713-5713. DOI: 10.1158/1538-7445.Am2020-5713  0.594
2020 Kuramoto J, Smith R, Kalasekar SM, Fulbright A, Ducker GS, Evason KJ. Abstract 3740: Role of phosphatidylcholine in β-catenin-driven hepatocellular carcinoma Cancer Research. 80: 3740-3740. DOI: 10.1158/1538-7445.Am2020-3740  0.308
2019 Bensard CL, Wisidigama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, ... ... Ducker GS, et al. Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell Metabolism. PMID 31813825 DOI: 10.1016/J.Cmet.2019.11.002  0.425
2019 Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, et al. Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Molecular Cancer Therapeutics. PMID 31289137 DOI: 10.1158/1535-7163.Mct-19-0037  0.62
2019 Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Serine Metabolism Supports Macrophage IL-1β Production. Cell Metabolism. PMID 30773464 DOI: 10.1016/J.Cmet.2019.01.014  0.503
2019 Dekhne A, Shah K, Ducker GS, Nayeen MJ, Katinas JM, Wong J, Doshi A, Bao X, Kalpage H, Liu J, Kim S, Wallace-Povirk A, Ning C, O'Connor C, Hou Z, et al. Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2992  0.563
2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, et al. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors. Molecular Cancer Therapeutics. PMID 30254185 DOI: 10.1158/1535-7163.Mct-17-1204  0.527
2018 Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT. 5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Molecular Genetics and Metabolism. PMID 30031689 DOI: 10.1016/J.Ymgme.2018.06.006  0.529
2018 Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. Plos One. 13: e0193849. PMID 29799846 DOI: 10.1371/Journal.Pone.0193849  0.551
2018 Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. PMID 29364879 DOI: 10.1038/Nature25460  0.567
2018 Dekhne AS, Ducker GS, Frühauf J, Shah K, Nayeen MJ, Wallace-Povirk A, O'Connor C, Hou Z, Polin L, Gangjee A, Rabinowitz JD, Matherly LH. Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates Cancer Research. 78: 3980-3980. DOI: 10.1158/1538-7445.Am2018-3980  0.626
2017 Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 114: 11404-11409. PMID 29073064 DOI: 10.1073/Pnas.1706617114  0.625
2017 Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD. An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate. Analytical and Bioanalytical Chemistry. PMID 28799108 DOI: 10.1007/S00216-017-0514-4  0.478
2016 Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metabolism. 24: 640-641. PMID 27732838 DOI: 10.1016/J.Cmet.2016.09.011  0.543
2016 Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metabolism. PMID 27641100 DOI: 10.1016/J.Cmet.2016.08.009  0.575
2016 Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metabolism. PMID 27211901 DOI: 10.1016/J.Cmet.2016.04.016  0.592
2016 Ducker GS, Esposito MB, Kang Y, Rabinowitz JD. Abstract A14: Role of mitochondrial folate metabolism in cancer cell growth and proliferation Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A14  0.617
2015 Ducker GS, Rabinowitz JD. ZMP: a master regulator of one-carbon metabolism. Molecular Cell. 57: 203-4. PMID 25616065 DOI: 10.1016/J.Molcel.2015.01.012  0.511
2015 Ducker GS, Chen L, Teng X, Rabinowitz JD. Abstract 4709: Compartmental flexibility in mammalian folate metabolism Cancer Research. 75: 4709-4709. DOI: 10.1158/1538-7445.Am2015-4709  0.516
2014 Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. Journal of Neurosurgery. 120: 331-6. PMID 24286145 DOI: 10.3171/2013.10.Jns13598  0.452
2014 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 33: 1590-600. PMID 23542178 DOI: 10.1038/Onc.2013.92  0.715
2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proceedings of the National Academy of Sciences of the United States of America. 110: 11988-93. PMID 23803853 DOI: 10.1073/Pnas.1310230110  0.585
2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A46  0.587
2013 Amin DN, Ahuja D, Ducker GS, Yaswen P, Shokat K, Moasser M. Abstract 3043: Akt-mTorc2 signaling underlies cellular addiction to HER3 signaling in HER2-amplified cancers. Cancer Research. 73: 3043-3043. DOI: 10.1158/1538-7445.Am2013-3043  0.545
2012 Ducker GS, Atreya CE, Simko J, Nakakura EK, Bergsland EK, Donner DB, Shokat KM, Warren RS. Effect of PIK3CA and KRAS mutations on sensitivity to ATP-competitive mTOR inhibitors in a primary xenograft model of colorectal carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 483. PMID 27982970 DOI: 10.1200/Jco.2012.30.4_Suppl.483  0.707
2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Investigational New Drugs. 30: 2219-25. PMID 22270257 DOI: 10.1007/S10637-012-9793-Y  0.735
2012 Ducker GS, Atreya CE, Shokat KM, Warren RS. Abstract PR4: Incomplete inhibition of phosphorylation of 4EBP1 is a mechanism for KRAS driven resistance to the ATP-competitive mTOR inhibitor PP242 in colorectal cancer Clinical Cancer Research. 18: PR4-PR4. DOI: 10.1158/1078-0432.Mechres-Pr4  0.713
2011 Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proceedings of the National Academy of Sciences of the United States of America. 108: 15201-6. PMID 21876130 DOI: 10.1073/Pnas.1103746108  0.695
2010 McCormick SR, McCormick MJ, Grutkoski PS, Ducker GS, Banerji N, Higgins RR, Mendiola JR, Reinartz JJ. FLT3 mutations at diagnosis and relapse in acute myeloid leukemia: cytogenetic and pathologic correlations, including cuplike blast morphology. Archives of Pathology & Laboratory Medicine. 134: 1143-51. PMID 20670134 DOI: 10.1043/2009-0292-Oa.1  0.32
2010 Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Molecular Biosystems. 6: 1389-402. PMID 20582381 DOI: 10.1039/C003917A  0.593
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