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Vicki L. McGovern, Ph.D. - Publications

Affiliations: 
2003 Ohio State University, Columbus, Columbus, OH 
Area:
Drosophila midline axon guidance
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Foust KD, Wang X, McGovern VL, Braun L, Bevan AK, Haidet AM, Le TT, Morales PR, Rich MM, Burghes AHM, Kaspar BK. Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN. Nature Biotechnology. PMID 36203015 DOI: 10.1038/s41587-022-01497-7  0.315
2021 Thomsen G, Burghes AHM, Hsieh C, Do J, Chu BTT, Perry S, Barkho B, Kaufmann P, Sproule DM, Feltner DE, Chung WK, McGovern VL, Hevner RF, Conces M, Pierson CR, et al. Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue. Nature Medicine. PMID 34608334 DOI: 10.1038/s41591-021-01483-7  0.394
2021 Blatnik AJ, McGovern VL, Burghes AHM. What Genetics Has Told Us and How It Can Inform Future Experiments for Spinal Muscular Atrophy, a Perspective. International Journal of Molecular Sciences. 22. PMID 34445199 DOI: 10.3390/ijms22168494  0.433
2021 Kray KM, McGovern VL, Chugh D, Arnold WD, Burghes AHM. Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice. Neurobiology of Disease. 159: 105488. PMID 34425216 DOI: 10.1016/j.nbd.2021.105488  0.471
2020 McGovern VL, Kray KM, Arnold WD, Duque SI, Iyer CC, Massoni-Laporte A, Workman E, Patel A, Battle DJ, Burghes AHM. Intragenic complementation of amino and carboxy terminal SMN missense mutations can rescue Smn null mice. Human Molecular Genetics. PMID 33084884 DOI: 10.1093/hmg/ddaa235  0.396
2019 Ruhno C, McGovern VL, Avenarius MR, Snyder PJ, Prior TW, Nery FC, Muhtaseb A, Roggenbuck JS, Kissel JT, Sansone VA, Siranosian JJ, Johnstone AJ, Nwe PH, Zhang RZ, Swoboda KJ, et al. Complete sequencing of the SMN2 gene in SMA patients detects SMN gene deletion junctions and variants in SMN2 that modify the SMA phenotype. Human Genetics. PMID 30788592 DOI: 10.1007/S00439-019-01983-0  0.456
2018 Iyer CC, Corlett KM, Massoni-Laporte A, Duque SI, Madabusi N, Tisdale S, McGovern VL, Le TT, Zaworski PG, David Arnold W, Pellizzoni L, Burghes AHM. Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. Human Molecular Genetics. PMID 29982416 DOI: 10.1093/Hmg/Ddy251  0.434
2017 Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Parsons J, Connolly AM, ... ... McGovern VL, et al. Natural History of Infantile-Onset Spinal Muscular Atrophy. Annals of Neurology. PMID 29149772 DOI: 10.1002/Ana.25101  0.345
2017 Wang X, Renusch SR, Duque SI, Wehr AM, Mo XM, McGovern VL, Arnold WD, Burghes AH, Kolb SJ. SMN Blood Levels in a Porcine Model of Spinal Muscular Atrophy. Journal of Neuromuscular Diseases. 4: 59-66. PMID 28269795 DOI: 10.3233/Jnd-170209  0.537
2017 Burghes A, McGovern V, Ruhno C, Prior T, Snyder P, Roggenbuck J, Sansone V, Kissel J. P.133 - Identification of variants that affect severity of the spinal muscular atrophy phenotype within and outside of the SMN2 gene Neuromuscular Disorders. 27. DOI: 10.1016/J.Nmd.2017.06.163  0.417
2016 Arnold WD, Duque S, Iyer CC, Zaworski P, McGovern VL, Taylor SJ, von Herrmann KM, Kobayashi DT, Chen KS, Kolb SJ, Paushkin SV, Burghes AH. Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration. Plos One. 11: e0167077. PMID 27907033 DOI: 10.1371/Journal.Pone.0167077  0.51
2016 Iyadurai S, Arnold WD, Kissel JT, Ruhno C, McGovern VL, Snyder PJ, Prior TW, Roggenbuck J, Burghes AH, Kolb SJ. Variable phenotypic expression and onset in MYH14 distal HMN phenotype in a large, multigenerational North American family. Muscle & Nerve. PMID 27875632 DOI: 10.1002/Mus.25491  0.321
2016 Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, ... ... McGovern VL, et al. Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study. Annals of Clinical and Translational Neurology. 3: 132-45. PMID 26900585 DOI: 10.1002/Acn3.283  0.319
2015 David Arnold W, McGovern VL, Sanchez B, Li J, Corlett KM, Kolb SJ, Rutkove SB, Burghes AH. The neuromuscular impact of symptomatic SMN restoration in a mouse model of spinal muscular atrophy. Neurobiology of Disease. PMID 26733414 DOI: 10.1016/J.Nbd.2015.12.014  0.427
2015 Iyer CC, McGovern VL, Murray JD, Gombash SE, Zaworski PG, Foust KD, Janssen PM, Burghes AH. Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA. Human Molecular Genetics. PMID 26276812 DOI: 10.1093/Hmg/Ddv332  0.459
2015 Gombash SE, Cowley CJ, Fitzgerald JA, Iyer CC, Fried D, McGovern VL, Williams KC, Burghes AH, Christofi FL, Gulbransen BD, Foust KD. SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice. Human Molecular Genetics. PMID 26223459 DOI: 10.1093/Hmg/Ddv292  0.346
2015 McGovern VL, Iyer CC, Arnold WD, Gombash SE, Zaworski PG, Blatnik AJ, Foust KD, Burghes AH. SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA. Human Molecular Genetics. 24: 5524-41. PMID 26206889 DOI: 10.1093/Hmg/Ddv283  0.541
2015 McGovern VL, Massoni-Laporte A, Wang X, Le TT, Le HT, Beattie CE, Rich MM, Burghes AH. Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse. Plos One. 10: e0132364. PMID 26134627 DOI: 10.1371/Journal.Pone.0132364  0.521
2015 Gombash SE, Cowley CJ, Fitzgerald JA, Iyer CC, Fried D, McGovern VL, Williams KC, Burghes AH, Christofi FL, Gulbransen BD, Foust KD. SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice. Human Molecular Genetics. 24: 3847-60. PMID 25859009 DOI: 10.1093/Hmg/Ddv127  0.433
2015 Meyer K, Ferraiuolo L, Schmelzer L, Braun L, McGovern V, Likhite S, Michels O, Govoni A, Fitzgerald J, Morales P, Foust KD, Mendell JR, Burghes AH, Kaspar BK. Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 477-87. PMID 25358252 DOI: 10.1038/Mt.2014.210  0.525
2015 Burghes A, Arnold W, McGovern V, Duque S, Li J, Iyer C, Corlett K, von Herrmann K, Zaworski P, Chen K, Kolb S, Paushkin S, Kobayashi D, Rutkove S. Response of biomarkers to treatment in mouse models of spinal muscular atrophy and response of SMA mice to later treatment Neuromuscular Disorders. 25: S193. DOI: 10.1016/J.Nmd.2015.06.036  0.322
2014 Iyer CC, McGovern VL, Wise DO, Glass DJ, Burghes AH. Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy. Neuromuscular Disorders : Nmd. 24: 436-44. PMID 24656734 DOI: 10.1016/J.Nmd.2014.02.007  0.397
2014 Arnold WD, Porensky PN, McGovern VL, Iyer CC, Duque S, Li X, Meyer K, Schmelzer L, Kaspar BK, Kolb SJ, Kissel JT, Burghes AH. Electrophysiological Biomarkers in Spinal Muscular Atrophy: Preclinical Proof of Concept. Annals of Clinical and Translational Neurology. 1: 34-44. PMID 24511555 DOI: 10.1002/Acn3.23  0.478
2014 Burghes A, McGovern V, Porensky P, Arnold W, Mitrpant C, Price L, Fletcher S, Wilton S. O10 Development of PMO antisense oligonucleotides for treatment of Spinal muscular atrophy Neuromuscular Disorders. 24: S3. DOI: 10.1016/S0960-8966(14)70011-2  0.333
2014 Burghes A, Arnold D, Duque S, McGovern V, Ruhno C, Iyer C, Meyer K, Kaspar B. G.O.15 Neuromuscular Disorders. 24: 919. DOI: 10.1016/J.Nmd.2014.06.414  0.531
2013 Burghes A, McGovern V, Porensky P, Arnold D, Laporte A, Foust K, Mitrpant C, Le T, Wilton S, Kaspar B. O.7 Spinal muscular atrophy: How it works and therapeutic targets Neuromuscular Disorders. 23: 797. DOI: 10.1016/J.Nmd.2013.06.557  0.553
2012 Porensky PN, Mitrpant C, McGovern VL, Bevan AK, Foust KD, Kaspar BK, Wilton SD, Burghes AH. A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse. Human Molecular Genetics. 21: 1625-38. PMID 22186025 DOI: 10.1093/Hmg/Ddr600  0.534
2012 Ruggiu M, McGovern VL, Lotti F, Saieva L, Li DK, Kariya S, Monani UR, Burghes AH, Pellizzoni L. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Molecular and Cellular Biology. 32: 126-38. PMID 22037760 DOI: 10.1128/Mcb.06077-11  0.526
2012 Burghes A, McGovern V, Porensky P, Duque S, Bevan A, Foust K, Odermatt P, Nlend R, Massoni-Laporte A, Mitrpant C, Wilton S, Schümperli D, Kaspar B. T.O.5 Spinal muscular atrophy SMA: SMNs spatial requirement and therapies Neuromuscular Disorders. 22: 907-908. DOI: 10.1016/J.Nmd.2012.06.342  0.525
2011 Le TT, McGovern VL, Alwine IE, Wang X, Massoni-Laporte A, Rich MM, Burghes AH. Temporal requirement for high SMN expression in SMA mice. Human Molecular Genetics. 20: 3578-91. PMID 21672919 DOI: 10.1093/Hmg/Ddr275  0.494
2011 Burghes A, Foust K, McGovern V, Poresnsky P, Bevan A, Duque S, Le T, Iyer C, Laporte A, Alwin I, Mitrpant C, Wilton S, Kaspar B. S.I.1 Development and preclinical evaluation of therapies for spinal muscular atrophy Neuromuscular Disorders. 21: 680. DOI: 10.1016/J.Nmd.2011.06.887  0.331
2010 Burghes AH, McGovern VL. Antisense oligonucleotides and spinal muscular atrophy: skipping along. Genes & Development. 24: 1574-9. PMID 20679391 DOI: 10.1101/Gad.1961710  0.504
2010 Bevan AK, Hutchinson KR, Foust KD, Braun L, McGovern VL, Schmelzer L, Ward JG, Petruska JC, Lucchesi PA, Burghes AH, Kaspar BK. Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Human Molecular Genetics. 19: 3895-905. PMID 20639395 DOI: 10.1093/Hmg/Ddq300  0.486
2010 Foust KD, Wang X, McGovern VL, Braun L, Bevan AK, Haidet AM, Le TT, Morales PR, Rich MM, Burghes AH, Kaspar BK. Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN. Nature Biotechnology. 28: 271-4. PMID 20190738 DOI: 10.1038/Nbt.1610  0.528
2008 McGovern VL, Gavrilina TO, Beattie CE, Burghes AH. Embryonic motor axon development in the severe SMA mouse. Human Molecular Genetics. 17: 2900-9. PMID 18603534 DOI: 10.1093/Hmg/Ddn189  0.475
2008 Gavrilina TO, McGovern VL, Workman E, Crawford TO, Gogliotti RG, DiDonato CJ, Monani UR, Morris GE, Burghes AH. Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. Human Molecular Genetics. 17: 1063-75. PMID 18178576 DOI: 10.1093/Hmg/Ddm379  0.529
2003 McGovern VL, Pacak CA, Sewell ST, Turski ML, Seeger MA. A targeted gain of function screen in the embryonic CNS of Drosophila. Mechanisms of Development. 120: 1193-207. PMID 14568107 DOI: 10.1016/S0925-4773(03)00159-X  0.493
2003 McGovern VL, Seeger MA. Mosaic analysis reveals a cell-autonomous, neuronal requirement for Commissureless in the Drosophila CNS. Development Genes and Evolution. 213: 500-4. PMID 12928898 DOI: 10.1007/S00427-003-0349-1  0.532
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