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Chunyu Wang, Ph.D. - Publications

Affiliations: 
2000 Cornell University, Ithaca, NY, United States 
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chiarolanzio KC, Pusztay JM, Chavez A, Zhao J, Xie J, Wang C, Mills KV. Allosteric influence of extremophile hairpin motif mutations on the protein splicing activity of a hyperthermophilic intein. Biochemistry. PMID 32559373 DOI: 10.1021/Acs.Biochem.0C00348  0.35
2020 Liu X, Zhao J, Zhang Y, Ubarretxena-Belandia I, Forth S, Lieberman RL, Wang C. Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype. Frontiers in Molecular Neuroscience. 13: 65. PMID 32508589 DOI: 10.3389/Fnmol.2020.00065  0.333
2020 Zhao J, Du Z, Wang C, Mills KV. Methods to Study the Structure and Catalytic Activity of cis-Splicing Inteins. Methods in Molecular Biology (Clifton, N.J.). 2133: 55-73. PMID 32144663 DOI: 10.1007/978-1-0716-0434-2_4  0.343
2020 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Substrate interaction inhibits γ-secretase production of amyloid-β peptides. Chemical Communications (Cambridge, England). PMID 32016207 DOI: 10.1039/C9Cc09170J  0.329
2020 Smith CJ, Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Giner JL, Xie J, Covey DF, Wang C, Callahan BP. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis. Biochemistry. PMID 32013401 DOI: 10.1021/Acs.Biochem.0C00013  0.318
2019 Zhao J, Ciulla DA, Xie J, Castillo DA, Wagner A, Zwarycz AS, Lin Z, Beadle S, Giner JL, Li Z, Li H, Banavali N, Callahan BP, Wang C. General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. Journal of the American Chemical Society. PMID 31682419 DOI: 10.1021/Jacs.9B08914  0.342
2019 Zhang X, Xu Z, Moumin DS, Ciulla DA, Owen TS, Mancusi RA, Giner JL, Wang C, Callahan BP. Protein-Nucleic Acid Conjugation with Sterol Linkers Using Hedgehog Autoprocessing. Bioconjugate Chemistry. PMID 31600061 DOI: 10.1021/Acs.Bioconjchem.9B00550  0.335
2019 Ciulla DA, Wagner AG, Liu X, Cooper CL, Jorgensen MT, Wang C, Goyal P, Banavali NK, Pezzullo JL, Giner JL, Callahan BP. Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism. Chemical Communications (Cambridge, England). PMID 30672911 DOI: 10.1039/C8Cc09729A  0.318
2019 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052  0.322
2018 Clemente N, Abdine A, Ubarretxena-Belandia I, Wang C. Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein. Scientific Reports. 8: 12411. PMID 30120254 DOI: 10.1038/S41598-018-30015-6  0.381
2017 Ramsoomair CK, Yakely AE, Urbanski LM, Karanja K, Giaccone ZT, Siegart NM, Wang C, Gomez AV, Reitter JN, Mills KV. Coordination of the third step of protein splicing in two cyanobacterial inteins. Febs Letters. PMID 28649707 DOI: 10.1002/1873-3468.12730  0.31
2017 Zwarycz AS, Fossat MJ, Akanyeti O, Lin Z, Rosenman DJ, Garcia AE, Royer CA, Mills KV, Wang C. V67L Mutation Fills Internal Cavity to Stabilize RecA Mtu Intein. Biochemistry. PMID 28488863 DOI: 10.1021/Acs.Biochem.6B01264  0.307
2017 Minteer CJ, Siegart NM, Colelli KM, Liu X, Linhardt RJ, Wang C, Gomez AV, Reitter JN, Mills KV. Intein-promoted cyclization of aspartic acid flanking the intein leads to atypical N-terminal cleavage. Biochemistry. PMID 28165720 DOI: 10.1021/Acs.Biochem.6B00894  0.352
2016 Xie J, Owen T, Xia K, Callahan B, Wang C. A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing. Journal of the American Chemical Society. PMID 27529645 DOI: 10.1021/Jacs.6B06928  0.302
2015 Rosenman DJ, Wang C, Garcia AE. Characterization of Aβ Monomers Through the Convergence of Ensemble Properties Among Simulations with Multiple Force Fields. The Journal of Physical Chemistry. B. PMID 26562747 DOI: 10.1021/Acs.Jpcb.5B09379  0.312
2015 Xie J, Owen T, Xia K, Singh AV, Tou E, Li L, Arduini B, Li H, Wan LQ, Callahan B, Wang C. Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activation. The Journal of Biological Chemistry. 290: 11591-600. PMID 25787080 DOI: 10.1016/J.Bpj.2014.11.2911  0.313
2015 Owen TS, Xie XJ, Laraway B, Ngoje G, Wang C, Callahan BP. Active site targeting of hedgehog precursor protein with phenylarsine oxide. Chembiochem : a European Journal of Chemical Biology. 16: 55-8. PMID 25418613 DOI: 10.1002/Cbic.201402421  0.315
2014 Chen W, Gamache E, Rosenman DJ, Xie J, Lopez MM, Li YM, Wang C. Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site. Nature Communications. 5: 3037. PMID 24390130 DOI: 10.1038/Ncomms4037  0.332
2014 Xie J, Du Z, Callahan B, Belfort M, Wang C. ¹H, ¹³C and ¹⁵N NMR assignments of a Drosophila Hedgehog autoprocessing domain. Biomolecular Nmr Assignments. 8: 279-81. PMID 23765287 DOI: 10.1007/S12104-013-9500-8  0.342
2014 Xie J, Du Z, Callahan B, Wang C. 1H, 13C, and 15N NMR Assignments of a Hedgehog Autoprocessing Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr19156  0.365
2014 Rosenman DJ, Clemente N, Wang C, García AE. Systematic Characterization of Wild Type and Familial Alzheimer's Disease Mutant Aβ Monomers Through the Convergence of Ensembles Simulated with Different Force Fields Biophysical Journal. 106: 269a. DOI: 10.1016/J.Bpj.2013.11.1578  0.31
2013 Nicastri MC, Xega K, Li L, Xie J, Wang C, Linhardt RJ, Reitter JN, Mills KV. Internal disulfide bond acts as a switch for intein activity. Biochemistry. 52: 5920-7. PMID 23906287 DOI: 10.1021/Bi400736C  0.31
2013 Rosenman DJ, Connors CR, Chen W, Wang C, García AE. Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach. Journal of Molecular Biology. 425: 3338-59. PMID 23811057 DOI: 10.1016/J.Bpj.2012.11.347  0.331
2013 Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Tranilast binds to aβ monomers and promotes aβ fibrillation. Biochemistry. 52: 3995-4002. PMID 23679559 DOI: 10.1021/Bi400426T  0.365
2012 Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. Acs Chemical Neuroscience. 3: 451-8. PMID 22860214 DOI: 10.1021/Cn200133X  0.347
2012 Zheng Y, Wu Q, Wang C, Xu MQ, Liu Y. Mutual synergistic protein folding in split intein. Bioscience Reports. 32: 433-42. PMID 22681309 DOI: 10.1042/Bsr20120049  0.314
2012 Chen W, Gamache E, Richardson D, Du Z, Wang C. Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies. Protein Expression and Purification. 81: 11-7. PMID 21907289 DOI: 10.1016/J.Pep.2011.08.006  0.345
2012 Rosenman DJ, Connors C, Chen W, Wang C, García AE. Characterization of the Structural Ensembles of Aβ Monomers using a Combined MD/NMR Approach Biophysical Journal. 102: 631a-632a. DOI: 10.1016/J.Bpj.2011.11.3439  0.339
2011 Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. Journal of Medicinal Chemistry. 54: 8451-60. PMID 22087474 DOI: 10.1021/Jm200982P  0.402
2011 Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, ... ... Wang C, et al. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society. 133: 16958-69. PMID 21916458 DOI: 10.1021/Ja206279B  0.362
2011 Du Z, Liu J, Albracht CD, Hsu A, Chen W, Marieni MD, Colelli KM, Williams JE, Reitter JN, Mills KV, Wang C. Structural and mutational studies of a hyperthermophilic intein from DNA polymerase II of Pyrococcus abyssi. The Journal of Biological Chemistry. 286: 38638-48. PMID 21914805 DOI: 10.1074/Jbc.M111.290569  0.391
2011 Du Z, Zheng Y, Patterson M, Liu Y, Wang C. pK(a) coupling at the intein active site: implications for the coordination mechanism of protein splicing with a conserved aspartate. Journal of the American Chemical Society. 133: 10275-82. PMID 21604815 DOI: 10.1021/Ja203209F  0.351
2011 Liu J, Du Z, Albracht CD, Naidu RO, Mills KV, Wang C. 1H, 13C, and 15N NMR assignments of the Pyrococcus abyssi DNA polymerase II intein. Biomolecular Nmr Assignments. 5: 233-5. PMID 21519863 DOI: 10.1007/S12104-011-9307-4  0.384
2011 Sgourakis NG, Merced-Serrano M, Boutsidis C, Drineas P, Du Z, Wang C, Garcia AE. Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms. Journal of Molecular Biology. 405: 570-83. PMID 21056574 DOI: 10.1016/J.Jmb.2010.10.015  0.365
2010 Du Z, Liu Y, Ban D, Lopez MM, Belfort M, Wang C. Backbone dynamics and global effects of an activating mutation in minimized Mtu RecA inteins. Journal of Molecular Biology. 400: 755-67. PMID 20562025 DOI: 10.1016/J.Jmb.2010.05.044  0.337
2009 Hiraga K, Soga I, Dansereau JT, Pereira B, Derbyshire V, Du Z, Wang C, Van Roey P, Belfort G, Belfort M. Selection and Structure of Hyperactive Inteins: Peripheral Changes Relayed to the Catalytic Center Journal of Molecular Biology. 393: 1106-1117. PMID 19744499 DOI: 10.1016/J.Jmb.2009.08.074  0.303
2009 Du Z, Shemella PT, Liu Y, McCallum SA, Pereira B, Nayak SK, Belfort G, Belfort M, Wang C. Highly conserved histidine plays a dual catalytic role in protein splicing: A pKa shift mechanism Journal of the American Chemical Society. 131: 11581-11589. PMID 19630416 DOI: 10.1021/Ja904318W  0.328
2008 Du Z, Liu Y, Zheng Y, McCallum S, Dansereau J, Derbyshire V, Belfort M, Belfort G, Roey PV, Wang C. 1H, 13C, and 15N NMR assignments of an engineered intein based on Mycobacterium tuberculosis RecA Biomolecular Nmr Assignments. 2: 111-113. PMID 19636882 DOI: 10.1007/S12104-008-9098-4  0.325
2008 Shinde AV, Bystroff C, Wang C, Vogelezang MG, Vincent PA, Hynes RO, Van De Water L. Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities. The Journal of Biological Chemistry. 283: 2858-70. PMID 17967897 DOI: 10.1074/Jbc.M708306200  0.331
2007 Sgourakis NG, Yan Y, McCallum SA, Wang C, Garcia AE. The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study. Journal of Molecular Biology. 368: 1448-57. PMID 17397862 DOI: 10.1016/J.Jmb.2007.02.093  0.311
2007 Yan Y, Liu Y, Sorci M, Belfort G, Lustbader JW, Yan SS, Wang C. Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Aβ interaction Biochemistry. 46: 1724-1731. PMID 17253767 DOI: 10.1021/Bi061314N  0.319
2006 Massi F, Wang C, Palmer AG. Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase. Biochemistry. 45: 10787-94. PMID 16953564 DOI: 10.1021/Bi060764C  0.366
2006 Loria J, Wang C, Massi F, Rance M, Palmer A. Backbone 1H, 13C, and 15N Chemical Shift Assignments for yeast triosephosphate isomerase, TIM Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7216  0.362
2006 Yan Y, Wang C. Aβ42 is More Rigid than Aβ40 at the C Terminus: Implications for Aβ Aggregation and Toxicity Journal of Molecular Biology. 364: 853-862. DOI: 10.1016/J.Jmb.2006.09.046  0.317
2005 Palmer AG, Grey MJ, Wang C. Solution NMR spin relaxation methods for characterizing chemical exchange in high-molecular-weight systems. Methods in Enzymology. 394: 430-65. PMID 15808232 DOI: 10.1016/S0076-6879(05)94018-4  0.324
2004 Wang C, Karpowich N, Hunt JF, Rance M, Palmer AG. Dynamics of ATP-binding cassette contribute to allosteric control, nucleotide binding and energy transduction in ABC transporters. Journal of Molecular Biology. 342: 525-37. PMID 15327952 DOI: 10.1016/J.Jmb.2004.07.001  0.344
2003 Wang C, Rance M, Palmer AG. Mapping chemical exchange in proteins with MW > 50 kD. Journal of the American Chemical Society. 125: 8968-9. PMID 15369325 DOI: 10.1021/Ja035139Z  0.36
2003 Grey MJ, Wang C, Palmer AG. Disulfide bond isomerization in basic pancreatic trypsin inhibitor: multisite chemical exchange quantified by CPMG relaxation dispersion and chemical shift modeling. Journal of the American Chemical Society. 125: 14324-35. PMID 14624581 DOI: 10.1021/Ja0367389  0.349
2003 Wang C, Palmer AG. Solution NMR methods for quantitative identification of chemical exchange in 15N-labeled proteins Magnetic Resonance in Chemistry. 41: 866-876. DOI: 10.1002/Mrc.1262  0.401
2002 Wang C, Hunt JF, Rance M, Palmer AG. 1H, 15N and 13C backbone assignment of MJ1267, an ATP-binding cassette. Journal of Biomolecular Nmr. 24: 167-8. PMID 12495036 DOI: 10.1023/A:1020959907518  0.366
2002 Wang C, Pawley N, Nicholson L. Backbone 1H and 15N Chemical Shift Assignment of c-Src SH3 complexed with RLP2 ligand in high salt solution Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr4889  0.741
2002 Wang C, Pawley N, Nicholson L. Backbone 1H and 15N Chemical Shift Assignment of c-Src SH3 in high salt solution Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr4888  0.737
2001 Wang C, Grey MJ, Palmer AG. CPMG sequences with enhanced sensitivity to chemical exchange. Journal of Biomolecular Nmr. 21: 361-6. PMID 11824755 DOI: 10.1023/A:1013328206498  0.319
2001 Wang C, Pawley NH, Nicholson LK. The role of backbone motions in ligand binding to the c-Src SH3 domain. Journal of Molecular Biology. 313: 873-87. PMID 11697910 DOI: 10.1006/Jmbi.2001.5083  0.74
2001 Pawley NH, Wang C, Koide S, Nicholson LK. An improved method for distinguishing between anisotropic tumbling and chemical exchange in analysis of 15N relaxation parameters. Journal of Biomolecular Nmr. 20: 149-65. PMID 11495246 DOI: 10.1023/A:1011249816560  0.732
2001 Wang C, Xi J, Begley TP, Nicholson LK. Solution structure of ThiS and implications for the evolutionary roots of ubiquitin. Nature Structural Biology. 8: 47-51. PMID 11135670 DOI: 10.1038/83041  0.613
2000 Cordier F, Wang C, Grzesiek S, Nicholson LK. Ligand-induced strain in hydrogen bonds of the c-Src SH3 domain detected by NMR. Journal of Molecular Biology. 304: 497-505. PMID 11099375 DOI: 10.1006/Jmbi.2000.4274  0.622
1992 Wang C, Teng Q, Cross TA. Solid-state C NMR spectroscopy of a C carbonyl-labeled polypeptide. Biophysical Journal. 61: 1550-6. PMID 19431834 DOI: 10.1016/S0006-3495(92)81959-8  0.552
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