Year |
Citation |
Score |
2023 |
Guengerich FP, McCarty KD, Tateishi Y, Liu L. Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1). Methods in Enzymology. 689: 39-63. PMID 37802581 DOI: 10.1016/bs.mie.2023.04.001 |
0.302 |
|
2023 |
Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T. Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical Research in Toxicology. PMID 37783573 DOI: 10.1021/acs.chemrestox.3c00229 |
0.537 |
|
2023 |
Lee SG, Kim V, Lee GH, Kim C, Jeong E, Guengerich FP, Kim D. Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1). Journal of Inorganic Biochemistry. 240: 112085. PMID 36640554 DOI: 10.1016/j.jinorgbio.2022.112085 |
0.497 |
|
2022 |
Chakraborty S, Mallick D, Goswami M, Guengerich FP, Chakrabarty A, Chowdhury G. The Natural Products Withaferin A and Withanone from the Medicinal Herb Are Covalent Inhibitors of the SARS-CoV-2 Main Protease. Journal of Natural Products. PMID 36098617 DOI: 10.1021/acs.jnatprod.2c00521 |
0.54 |
|
2022 |
Ghodke PP, Matse JH, Dawson S, Guengerich FP. Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA. Chemical Research in Toxicology. PMID 35482010 DOI: 10.1021/acs.chemrestox.2c00068 |
0.771 |
|
2022 |
Shimada T, Nagayoshi H, Murayama N, Sawai A, Kim V, Kim D, Yamazaki H, Guengerich FP, Takenaka S. Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 52: 134-145. PMID 35387543 DOI: 10.1080/00498254.2022.2062486 |
0.518 |
|
2021 |
Ghodke PP, Guengerich FP. DNA polymerases η and κ bypass N-guanine-O-alkylguanine DNA alkyltransferase crosslinked DNA-peptides. The Journal of Biological Chemistry. 101124. PMID 34461101 DOI: 10.1016/j.jbc.2021.101124 |
0.764 |
|
2021 |
Kim D, Kim V, Tateishi Y, Guengerich FP. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 34330716 DOI: 10.1124/dmd.121.000475 |
0.524 |
|
2021 |
Nagayoshi H, Murayama N, Takenaka S, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-47. PMID 34224301 DOI: 10.1080/00498254.2021.1950866 |
0.53 |
|
2021 |
Guengerich FP, Ghodke PP. Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society. 43: 24. PMID 34130743 DOI: 10.1186/s41021-021-00199-x |
0.776 |
|
2021 |
Ghodke PP, Mali JR, Patra A, Rizzo CJ, Guengerich FP, Egli M. Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N-ethenodeoxyguanosine by human DNA translesion polymerase η. The Journal of Biological Chemistry. 100642. PMID 33839151 DOI: 10.1016/j.jbc.2021.100642 |
0.761 |
|
2021 |
Kim D, Kim V, McCarty KD, Guengerich FP. Tight binding of cytochrome b to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. The Journal of Biological Chemistry. 100571. PMID 33753170 DOI: 10.1016/j.jbc.2021.100571 |
0.501 |
|
2021 |
Ghodke PP, Gonzalez-Vasquez G, Wang H, Johnson KM, Sedgeman CA, Guengerich FP. Enzymatic bypass of an N-deoxyadenosine DNA-ethylene dibromide-peptide crosslink by translesion DNA polymerases. The Journal of Biological Chemistry. 100444. PMID 33617883 DOI: 10.1016/j.jbc.2021.100444 |
0.761 |
|
2021 |
Rendic SP, Guengerich FP. Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology. 95: 395-472. PMID 33459808 DOI: 10.1007/s00204-020-02971-4 |
0.3 |
|
2020 |
Shimada T, Nagayoshi H, Murayama N, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP. Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-55. PMID 33047997 DOI: 10.1080/00498254.2020.1836433 |
0.505 |
|
2020 |
Child SA, Reddish MJ, Glass SM, Goldfarb MH, Barckhausen IR, Guengerich FP. Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes. Archives of Biochemistry and Biophysics. 694: 108596. PMID 32980349 DOI: 10.1016/j.abb.2020.108596 |
0.304 |
|
2020 |
Ahmed N, Chakrabarty A, Guengerich FP, Chowdhury G. Protective Role of Glutathione Against Peroxynitrite-Mediated DNA Damage During Acute Inflammation. Chemical Research in Toxicology. PMID 32894672 DOI: 10.1021/Acs.Chemrestox.0C00299 |
0.606 |
|
2020 |
Guengerich FP. A history of the roles of cytochrome P450 enzymes in the toxicity of drugs. Toxicological Research. 1-23. PMID 32837681 DOI: 10.1007/S43188-020-00056-Z |
0.308 |
|
2020 |
Yeom M, Hong JK, Kim JK, Guengerich FP, Choi JY. Three Human Pol Variants with Impaired Polymerase Activity Fail to Rescue HO Sensitivity in -Deficient Cells. Chemical Research in Toxicology. PMID 32635723 DOI: 10.1021/Acs.Chemrestox.0C00127 |
0.354 |
|
2020 |
Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI. A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis. The Journal of Biological Chemistry. PMID 32493730 DOI: 10.1074/Jbc.Ra120.014064 |
0.341 |
|
2020 |
Nagayoshi H, Murayama N, Tsujino M, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. Preference for -demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-42. PMID 32312164 DOI: 10.1080/00498254.2020.1759157 |
0.571 |
|
2020 |
Child SA, Guengerich FP. Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. Journal of Medicinal Chemistry. 63: 6513-6522. PMID 32223238 DOI: 10.1021/Acs.Jmedchem.9B01849 |
0.388 |
|
2020 |
Ghodke PP, Guengerich FP. Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair. Journal of Biological Chemistry. 295: 6092-6107. PMID 32213600 DOI: 10.1074/Jbc.Ra120.012829 |
0.772 |
|
2020 |
Guengerich FP. Cytochrome P450 2E1 and its roles in disease. Chemico-Biological Interactions. 322: 109056. PMID 32198084 DOI: 10.1016/J.Cbi.2020.109056 |
0.396 |
|
2020 |
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA. In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. Journal of Medicinal Chemistry. 63: 6477-6488. PMID 31617715 DOI: 10.1021/Acs.Jmedchem.9B01383 |
0.39 |
|
2020 |
Guengerich FP, Fekry MI. Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition Acs Catalysis. 10: 5008-5022. DOI: 10.1021/Acscatal.0C00677 |
0.317 |
|
2019 |
Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W. Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. The Journal of Biological Chemistry. PMID 31811088 DOI: 10.1074/Jbc.Rev119.008758 |
0.373 |
|
2019 |
Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI. Validation of human sterol 14α-demethylase (CYP51) druggability: structure-guided design, synthesis and evaluation of stoichiometric, functionally irreversible inhibitors. Journal of Medicinal Chemistry. PMID 31663733 DOI: 10.1021/Acs.Jmedchem.9B01485 |
0.328 |
|
2019 |
Fekry MI, Xiao Y, Berg JZ, Guengerich FP. A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31511258 DOI: 10.1124/Dmd.119.089086 |
0.417 |
|
2019 |
Reddish MJ, Guengerich FP. Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone. Journal of Biological Chemistry. 294: 12975-12991. PMID 31296661 DOI: 10.1074/Jbc.Ra119.009830 |
0.407 |
|
2019 |
Guengerich FP, Wilkey CJ, Phan TTN. Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. The Journal of Biological Chemistry. PMID 31147443 DOI: 10.1074/Jbc.Ra119.009305 |
0.399 |
|
2019 |
Chattopadhyay M, Roy Chowdhury A, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani N. Mitochondria-targeted cytochrome P450 CYP2D6 is involved in monomethylamine-induced neuronal damage in mouse models. The Journal of Biological Chemistry. PMID 31113867 DOI: 10.1074/Jbc.Ra119.008848 |
0.305 |
|
2019 |
Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ. Conformational selection dominates binding of steroids to human cytochrome P450 17A1. The Journal of Biological Chemistry. PMID 31072872 DOI: 10.1074/Jbc.Ra119.008860 |
0.401 |
|
2019 |
Nagayoshi H, Murayama N, Kakimoto K, Tsujino M, Takenaka S, Katahira J, Lim YR, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology. PMID 30964977 DOI: 10.1021/Acs.Chemrestox.9B00078 |
0.59 |
|
2019 |
Albertolle ME, Glass SM, Trefts E, Guengerich FP. Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells. The Journal of Biological Chemistry. PMID 30850396 DOI: 10.1074/Jbc.Ac118.007225 |
0.308 |
|
2019 |
Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP. Human DNA polymerase has reverse transcriptase activity in cellular environments. The Journal of Biological Chemistry. PMID 30842261 DOI: 10.1074/Jbc.Ra119.007925 |
0.776 |
|
2019 |
Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP. Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1. Chemical Research in Toxicology. PMID 30701961 DOI: 10.1021/Acs.Chemrestox.8B00353 |
0.421 |
|
2019 |
Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP. Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks. Current Protocols in Nucleic Acid Chemistry. e74. PMID 30657645 DOI: 10.1002/Cpnc.74 |
0.783 |
|
2019 |
Guengerich FP. Cytochrome P450 research and The Journal of Biological Chemistry. Journal of Biological Chemistry. 294: 1671-1680. PMID 29871932 DOI: 10.1074/Jbc.Tm118.004144 |
0.37 |
|
2019 |
Murayama N, Guengerich FP, Yamazaki H. Cytochrome P450 3A enzyme-dependent thalidomide toxicity and inducibility in cultured human placental cells Drug Metabolism and Pharmacokinetics. 34. DOI: 10.1016/J.Dmpk.2018.09.107 |
0.383 |
|
2018 |
Guengerich FP. Mechanisms of Cytochrome P450-Catalyzed Oxidations Acs Catalysis. 8: 10964-10976. PMID 31105987 DOI: 10.1021/Acscatal.8B03401 |
0.425 |
|
2018 |
Rendic SP, Guengerich FP. Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits. Drug Metabolism Reviews. 50: 256-342. PMID 30717606 DOI: 10.1080/03602532.2018.1483401 |
0.392 |
|
2018 |
Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Bastaki M, Davidsen JM, Harman CL, McGowen M, Taylor SV. FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30481573 DOI: 10.1016/J.Fct.2018.11.052 |
0.385 |
|
2018 |
Friggeri L, Hargrove TY, Rachakonda G, Blobaum AL, Fisher P, de Oliveira GM, da Silva CF, Soeiro MNC, Nes WD, Lindsley CW, Villalta F, Guengerich FP, Lepesheva GI. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. Journal of Medicinal Chemistry. PMID 30451500 DOI: 10.1021/Acs.Jmedchem.8B01671 |
0.309 |
|
2018 |
Guengerich FP, Avadhani NG. Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens. Advances in Experimental Medicine and Biology. 1032: 15-35. PMID 30362088 DOI: 10.1007/978-3-319-98788-0_2 |
0.382 |
|
2018 |
Hargrove TY, Wawrzak Z, Fisher PM, Child SA, Nes WD, Guengerich FP, Waterman MR, Lepesheva GI. Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. The Journal of Biological Chemistry. PMID 30327430 DOI: 10.1074/Jbc.Ra118.005850 |
0.37 |
|
2018 |
Smith RL, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Guengerich FP, Rietjens IMCM, Bastaki M, Harman CL, McGowen MM, Taylor SV. The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research. 7: 618-646. PMID 30090611 DOI: 10.1039/C7Tx00254H |
0.429 |
|
2018 |
Nagayoshi H, Murayama N, Kakimoto K, Takenaka S, Katahira J, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-51. PMID 30048196 DOI: 10.1080/00498254.2018.1505064 |
0.558 |
|
2018 |
Sausville LN, Gangadhariah M, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. The cytochrome P450 slow metabolizers CYP2C9*2 and CYP2C9*3 directly regulate tumorigenesis via reduced epoxyeicosatrienoic acid production. Cancer Research. PMID 30012669 DOI: 10.1158/0008-5472.Can-17-3977 |
0.344 |
|
2018 |
Albertolle ME, Guengerich FP. The relationships between cytochromes P450 and H2O2: Production, reaction, and inhibition. Journal of Inorganic Biochemistry. 186: 228-234. PMID 29990746 DOI: 10.1016/J.Jinorgbio.2018.05.014 |
0.41 |
|
2018 |
Guengerich FP, Yoshimoto FK. Formation and Cleavage of C-C Bonds by Enzymatic Oxidation-Reduction Reactions. Chemical Reviews. 118: 6573-6655. PMID 29932643 DOI: 10.1021/Acs.Chemrev.8B00031 |
0.36 |
|
2018 |
Albertolle M, Phan TTN, Pozzi A, Guengerich FP. Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metabolizing Enzymes as a Response to Redox Alteration. Molecular & Cellular Proteomics : McP. PMID 29374135 DOI: 10.1074/Mcp.Ra117.000382 |
0.441 |
|
2018 |
Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Davidsen JM, Harman CL, Taylor SV. Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 29355624 DOI: 10.1016/J.Fct.2018.01.021 |
0.363 |
|
2018 |
Kakimoto K, Murayama N, Takenaka S, Nagayoshi H, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Cytochrome P450 2A6 and Other Human P450 Enzymes in the Oxidation of Flavone and Flavanone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-49. PMID 29310511 DOI: 10.1080/00498254.2018.1426133 |
0.602 |
|
2018 |
Yamazaki H, Murayama N, Shimizu M, Guengerich FP. Induction of human cytochrome P450 3A enzymes in hepatic and placental cells by thalidomide and relevance to bioactivation Drug Metabolism and Pharmacokinetics. 33. DOI: 10.1016/J.Dmpk.2017.11.114 |
0.398 |
|
2017 |
Gonzalez E, Johnson KM, Pallan PS, Phan TTN, Zhang W, Lei LI, Wawrzak Z, Yoshimoto FK, Egli M, Guengerich FP. Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes. The Journal of Biological Chemistry. PMID 29212707 DOI: 10.1074/Jbc.Ra117.000504 |
0.4 |
|
2017 |
Su Y, Egli M, Guengerich FP. Human DNA polymerase η accommodates RNA for strand extension. The Journal of Biological Chemistry. PMID 28972162 DOI: 10.1074/Jbc.M117.809723 |
0.34 |
|
2017 |
Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G. The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. Chemical Research in Toxicology. PMID 28745489 DOI: 10.1021/Acs.Chemrestox.7B00127 |
0.639 |
|
2017 |
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP. Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol. The Journal of Biological Chemistry. PMID 28701464 DOI: 10.1074/Jbc.M116.773937 |
0.385 |
|
2017 |
Gonzalez E, Guengerich FP. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. The Journal of Biological Chemistry. PMID 28684414 DOI: 10.1074/Jbc.M117.794917 |
0.406 |
|
2017 |
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M. Oxidation of 1-Chloropyrene by Human CYP1 Family and CYP2A Subfamily Cytochrome P450 Enzymes: Catalytic Roles of Two CYP1B1 and Five CYP2A13 Allelic Variants. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-42. PMID 28648140 DOI: 10.1080/00498254.2017.1347306 |
0.58 |
|
2017 |
Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA. In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. The Journal of Biological Chemistry. PMID 28642370 DOI: 10.1074/Jbc.M117.794909 |
0.338 |
|
2017 |
Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP. Functional Analysis of Human Cytochrome P450 21A2 Variants Involved in Congenital Adrenal Hyperplasia. The Journal of Biological Chemistry. PMID 28539365 DOI: 10.1074/Jbc.M117.792465 |
0.421 |
|
2017 |
Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas U, Johnson EF, Guengerich FP. Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. The Journal of Biological Chemistry. PMID 28533430 DOI: 10.1074/Jbc.M117.792200 |
0.585 |
|
2017 |
Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H. Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. The Journal of Toxicological Sciences. 42: 343-348. PMID 28496040 DOI: 10.2131/Jts.42.343 |
0.416 |
|
2017 |
Sedgeman CA, Su Y, Guengerich FP. Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases. Chemical Research in Toxicology. PMID 28395138 DOI: 10.1021/Acs.Chemrestox.7B00022 |
0.378 |
|
2017 |
Marsch GA, Carlson BT, Guengerich FP. 7,8-Benzoflavone Binding to Human Cytochrome P450 3A4 Reveals Complex Fluorescence Quenching, Suggesting Binding at Multiple Protein Sites. Journal of Biomolecular Structure & Dynamics. 1-74. PMID 28278026 DOI: 10.1080/07391102.2017.1301270 |
0.375 |
|
2016 |
Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV. Safety evaluation of substituted thiophenes used as flavoring ingredients. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27836750 DOI: 10.1016/J.Fct.2016.10.023 |
0.408 |
|
2016 |
Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Taylor SV. FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27773699 DOI: 10.1016/J.Fct.2016.10.020 |
0.466 |
|
2016 |
Patra A, Zhang Q, Guengerich FP, Egli M. Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η. The Journal of Biological Chemistry. 291: 24304-24313. PMID 27694439 DOI: 10.1074/Jbc.M116.755462 |
0.353 |
|
2016 |
Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M. Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27625140 DOI: 10.1124/Dmd.116.072991 |
0.59 |
|
2016 |
Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Scharer OD, Sham YY, Tretyakova N. Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases. The Journal of Biological Chemistry. PMID 27621316 DOI: 10.1074/Jbc.M116.745257 |
0.368 |
|
2016 |
Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY. Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. Chemical Research in Toxicology. PMID 27603496 DOI: 10.1021/Acs.Chemrestox.6B00244 |
0.356 |
|
2016 |
Yoshimoto FK, Jung IJ, Goyal S, Guengerich FP, Gonzalez E. Isotope-Labeling Studies Support an Electrophilic Compound I Iron Active Species (FeO3+) for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side Chain Cleavage Enzyme, Cytochrome P450 11A1 (P450SCC). Journal of the American Chemical Society. PMID 27571509 DOI: 10.1021/Jacs.6B04437 |
0.353 |
|
2016 |
Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong HL, Guengerich FP, Liebler DC. Specificity of protein covalent modification by the electrophilic proteasome inhibitor carfilzomib in human cells. Molecular & Cellular Proteomics : McP. PMID 27503896 DOI: 10.1074/Mcp.M116.059709 |
0.324 |
|
2016 |
Guengerich FP. Intersection of Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates. Relevance to Toxicity and Drug Interactions. Chemical Research in Toxicology. PMID 27472660 DOI: 10.1021/Acs.Chemrestox.6B00226 |
0.413 |
|
2016 |
Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP. Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-chromosome or Hepatocytes by Two-dimensional Electrophoresis/Accelerator Mass Spectrometry. Chemical Research in Toxicology. PMID 27464947 DOI: 10.1021/Acs.Chemrestox.6B00210 |
0.388 |
|
2016 |
Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP. Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1. 18O-Labeling and Oxygen Surrogate Evidence for a Role of a Perferryl Oxygen. The Journal of Biological Chemistry. PMID 27339894 DOI: 10.1074/Jbc.M116.732966 |
0.364 |
|
2016 |
Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP. Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, And Physiologically-Based Pharmacokinetic Modeling in Toxicology. Chemical Research in Toxicology. PMID 27337115 DOI: 10.1021/Acs.Chemrestox.6B00136 |
0.347 |
|
2016 |
Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D. Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. Scientific Reports. 6: 28462. PMID 27334049 DOI: 10.1038/Srep28462 |
0.323 |
|
2016 |
Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI. Human sterol 14α-demethylase (CYP51) as a target for anticancer chemotherapy: Towards structure-aided drug design. Journal of Lipid Research. PMID 27313059 DOI: 10.1194/Jlr.M069229 |
0.316 |
|
2016 |
Savas U, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. 20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor. The Journal of Biological Chemistry. PMID 27298316 DOI: 10.1074/Jbc.M116.732297 |
0.321 |
|
2016 |
Guengerich FP, Waterman MR, Egli M. Recent Structural Insights into Cytochrome P450 Function. Trends in Pharmacological Sciences. PMID 27267697 DOI: 10.1016/J.Tips.2016.05.006 |
0.363 |
|
2016 |
Liu B, Xue Q, Tang Y, Cao J, Guengerich FP, Zhang H. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Mutation Research. Reviews in Mutation Research. 768: 53-67. PMID 27234563 DOI: 10.1016/J.Mrrev.2016.03.006 |
0.348 |
|
2016 |
Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M. Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. The Journal of Biological Chemistry. PMID 27226627 DOI: 10.1074/Jbc.M116.732487 |
0.365 |
|
2016 |
Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and their Alkynyl Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. PMID 27137136 DOI: 10.1021/Acs.Chemrestox.6B00083 |
0.55 |
|
2016 |
Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chemical Research in Toxicology. PMID 26914252 DOI: 10.1021/Acs.Chemrestox.5B00513 |
0.351 |
|
2016 |
Su Y, Egli M, Guengerich FP. Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. The Journal of Biological Chemistry. PMID 26740629 DOI: 10.1074/Jbc.M115.706226 |
0.354 |
|
2015 |
Xue Q, Zhong M, Liu B, Tang Y, Wei Z, Guengerich FP, Zhang H. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. Biochimie. PMID 26700143 DOI: 10.1016/J.Biochi.2015.12.009 |
0.381 |
|
2015 |
O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ. Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. Biochemistry. 54: 7449-56. PMID 26624500 DOI: 10.1021/Acs.Biochem.5B01078 |
0.376 |
|
2015 |
Hargrove TY, Wawrzak Z, Lamb DC, Guengerich FP, Lepesheva GI. Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs. The Journal of Biological Chemistry. 290: 23916-34. PMID 26269599 DOI: 10.1074/Jbc.M115.677310 |
0.355 |
|
2015 |
Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-14. PMID 26247835 DOI: 10.3109/00498254.2015.1069419 |
0.591 |
|
2015 |
Pallan PS, Lei L, Wang C, Waterman MR, Guengerich FP, Egli M. Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia. Molecular Endocrinology (Baltimore, Md.). 29: 1375-84. PMID 26172259 DOI: 10.1210/Me.2015-1127 |
0.365 |
|
2015 |
Kramlinger VM, Alvarado Rojas M, Kanamori T, Guengerich FP. Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis. The Journal of Biological Chemistry. 290: 20200-10. PMID 26157146 DOI: 10.1074/Jbc.M115.665331 |
0.367 |
|
2015 |
Guengerich FP. Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases. The Journal of Biological Chemistry. 290: 20700-1. PMID 26152720 DOI: 10.1074/Jbc.R115.675652 |
0.336 |
|
2015 |
Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY. Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Chemical Research in Toxicology. 28: 1496-507. PMID 26098310 DOI: 10.1021/Acs.Chemrestox.5B00166 |
0.314 |
|
2015 |
Su Y, Patra A, Harp JM, Egli M, Guengerich FP. Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. The Journal of Biological Chemistry. 290: 15921-33. PMID 25947374 DOI: 10.1074/Jbc.M115.653691 |
0.349 |
|
2015 |
Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. The Journal of Biological Chemistry. 290: 13128-43. PMID 25855791 DOI: 10.1074/Jbc.M115.646307 |
0.417 |
|
2015 |
Boji? M, Sedgeman CA, Nagy LD, Guengerich FP. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 73: 49-56. PMID 25840124 DOI: 10.1016/J.Ejps.2015.03.015 |
0.385 |
|
2015 |
Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, et al. Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo. Nucleic Acids Research. 43: 5489-500. PMID 25837992 DOI: 10.1093/Nar/Gkv243 |
0.305 |
|
2015 |
Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B. Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Dna Repair. 30: 1-10. PMID 25797601 DOI: 10.1016/J.Dnarep.2015.02.021 |
0.387 |
|
2015 |
Chowdhury G, Guengerich FP. Characterization of thioether-linked protein adducts of DNA using a raney-ni-mediated desulfurization method and liquid chromatography-electrospray-tandem mass spectrometry. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 60: 10.15.1-10.15.14. PMID 25754888 DOI: 10.1002/0471142700.Nc1015S60 |
0.613 |
|
2015 |
Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP. Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. The Journal of Biological Chemistry. 290: 8028-38. PMID 25666608 DOI: 10.1074/Jbc.M115.637561 |
0.347 |
|
2015 |
Shimada T, Takenaka S, Murayama N, Yamazaki H, Kim JH, Kim D, Yoshimoto FK, Guengerich FP, Komori M. Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology. PMID 25642975 DOI: 10.1021/Tx500505Y |
0.568 |
|
2015 |
Lajovic A, Nagy LD, Guengerich FP, Bren U. Carcinogenesis of urethane: simulation versus experiment. Chemical Research in Toxicology. 28: 691-701. PMID 25642734 DOI: 10.1021/Tx500459T |
0.327 |
|
2015 |
Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. The Journal of Biological Chemistry. 290: 3248-68. PMID 25533464 DOI: 10.1074/Jbc.M114.627265 |
0.407 |
|
2015 |
Rendic S, Guengerich FP. Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. Chemical Research in Toxicology. 28: 38-42. PMID 25485457 DOI: 10.1021/Tx500444E |
0.43 |
|
2015 |
Guengerich FP, Zhao L, Pence MG, Egli M. Structure and function of the translesion DNA polymerases and interactions with damaged DNA Perspectives in Science. 4: 24-31. DOI: 10.1016/J.Pisc.2014.12.005 |
0.363 |
|
2015 |
Guengerich FP. Human cytochrome P450 enzymes Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition. 523-785. DOI: 10.1007/978-3-319-12108-6_9 |
0.304 |
|
2014 |
O'Flaherty DK, Guengerich FP. Steady-state kinetic analysis of DNA polymerase single-nucleotide incorporation products. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 59: 7.21.1-7.21.13. PMID 25501593 DOI: 10.1002/0471142700.Nc0721S59 |
0.35 |
|
2014 |
Yoshimoto FK, Guengerich FP. Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Journal of the American Chemical Society. 136: 15016-25. PMID 25252141 DOI: 10.1021/Ja508185D |
0.365 |
|
2014 |
Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 53: 6161-72. PMID 25203493 DOI: 10.1021/Bi500710E |
0.58 |
|
2014 |
Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chemical Research in Toxicology. 27: 1837-52. PMID 25162224 DOI: 10.1021/Tx5002755 |
0.365 |
|
2014 |
Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. The Journal of Biological Chemistry. 289: 29614-30. PMID 25160618 DOI: 10.1074/Jbc.M114.583062 |
0.321 |
|
2014 |
Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. The Febs Journal. 281: 4394-410. PMID 25065501 DOI: 10.1111/Febs.12947 |
0.34 |
|
2014 |
Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. Journal of Lipid Research. 55: 1933-43. PMID 25017465 DOI: 10.1194/Jlr.M051508 |
0.406 |
|
2014 |
Bojić M, Barbero L, Dolgos H, Freisleben A, Gallemann D, Riva S, Guengerich FP. Time- and NADPH-dependent inhibition of cytochrome P450 3A4 by the cyclopentapeptide cilengitide: significance of the guanidine group and accompanying spectral changes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1438-46. PMID 24985702 DOI: 10.1124/Dmd.114.059295 |
0.412 |
|
2014 |
Song I, Kim EJ, Kim IH, Park EM, Lee KE, Shin JH, Guengerich FP, Choi JY. Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. Chemical Research in Toxicology. 27: 919-30. PMID 24725253 DOI: 10.1021/Tx500072M |
0.369 |
|
2014 |
Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S, Guengerich FP. Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. The Journal of Biological Chemistry. 289: 10476-87. PMID 24563460 DOI: 10.1074/Jbc.M114.550004 |
0.396 |
|
2014 |
Murayama N, van Beuningen R, Suemizu H, Guguen-Guillouzo C, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H. Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chemical Research in Toxicology. 27: 304-8. PMID 24460184 DOI: 10.1021/Tx4004374 |
0.387 |
|
2014 |
Chowdhury G, Shibata N, Yamazaki H, Guengerich FP. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. Chemical Research in Toxicology. 27: 147-56. PMID 24350712 DOI: 10.1021/Tx4004215 |
0.672 |
|
2014 |
Guengerich FP. Cytochrome P450 Enzymes Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.01960-7 |
0.314 |
|
2013 |
Guengerich FP. Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions. Journal of Labelled Compounds & Radiopharmaceuticals. 56: 428-31. PMID 24285515 DOI: 10.1002/Jlcr.3031 |
0.402 |
|
2013 |
Cho SH, Guengerich FP. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. Chemical Research in Toxicology. 26: 1765-74. PMID 24191644 DOI: 10.1021/Tx4003534 |
0.358 |
|
2013 |
Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Biochemistry. 52: 8766-76. PMID 24171480 DOI: 10.1021/Bi401103K |
0.379 |
|
2013 |
Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE. Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. Biochemistry. 52: 8276-85. PMID 24138531 DOI: 10.1021/Bi401208M |
0.343 |
|
2013 |
Chowdhury G, Cho SH, Pegg AE, Guengerich FP. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Angewandte Chemie (International Ed. in English). 52: 12879-82. PMID 24130045 DOI: 10.1002/Anie.201307580 |
0.633 |
|
2013 |
Stornetta A, Angelov T, Guengerich FP, Sturla SJ. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Chembiochem : a European Journal of Chemical Biology. 14: 1634-9. PMID 23959784 DOI: 10.1002/Cbic.201300296 |
0.349 |
|
2013 |
Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochemical Pharmacology. 86: 548-60. PMID 23792120 DOI: 10.1016/J.Bcp.2013.06.006 |
0.35 |
|
2013 |
Cho SH, Guengerich FP. Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases. Chemical Research in Toxicology. 26: 1005-13. PMID 23701509 DOI: 10.1021/Tx400145E |
0.378 |
|
2013 |
Wang K, Guengerich FP. Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1. Chemical Research in Toxicology. 26: 993-1004. PMID 23682735 DOI: 10.1021/Tx400139P |
0.428 |
|
2013 |
Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. The Journal of Toxicological Sciences. 38: 349-54. PMID 23665933 DOI: 10.2131/Jts.38.349 |
0.342 |
|
2013 |
Guengerich FP, Munro AW. Unusual cytochrome p450 enzymes and reactions. The Journal of Biological Chemistry. 288: 17065-73. PMID 23632016 DOI: 10.1074/Jbc.R113.462275 |
0.402 |
|
2013 |
Guengerich FP. New trends in cytochrome p450 research at the half-century mark. The Journal of Biological Chemistry. 288: 17063-4. PMID 23632015 DOI: 10.1074/Jbc.R113.466821 |
0.387 |
|
2013 |
Akiyoshi T, Ito M, Murase S, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. Drug Metabolism and Pharmacokinetics. 28: 411-5. PMID 23514827 DOI: 10.2133/Dmpk.Dmpk-12-Rg-134 |
0.354 |
|
2013 |
Cheng Q, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Methods in Molecular Biology (Clifton, N.J.). 987: 157-62. PMID 23475676 DOI: 10.1007/978-1-62703-321-3_14 |
0.381 |
|
2013 |
Cheng Q, Guengerich FP. Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches. Methods in Molecular Biology (Clifton, N.J.). 987: 71-7. PMID 23475668 DOI: 10.1007/978-1-62703-321-3_6 |
0.352 |
|
2013 |
Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP. Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. 26: 529-37. PMID 23432465 DOI: 10.1021/Tx3004906 |
0.586 |
|
2013 |
Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Chemical Research in Toxicology. 26: 517-28. PMID 23432429 DOI: 10.1021/Tx300492J |
0.568 |
|
2013 |
Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. Chemical Research in Toxicology. 26: 486-9. PMID 23419139 DOI: 10.1021/Tx400008G |
0.378 |
|
2013 |
Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP. Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. Archives of Biochemistry and Biophysics. 530: 101-7. PMID 23357279 DOI: 10.1016/J.Abb.2013.01.001 |
0.403 |
|
2013 |
Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. The Journal of Biological Chemistry. 288: 4436-51. PMID 23258538 DOI: 10.1074/Jbc.M112.402123 |
0.595 |
|
2012 |
Chowdhury G, Calcutt MW, Nagy LD, Guengerich FP. Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Biochemistry. 51: 9995-10007. PMID 23186213 DOI: 10.1021/Bi301092C |
0.658 |
|
2012 |
Kotapati S, Maddukuri L, Wickramaratne S, Seneviratne U, Goggin M, Pence MG, Villalta P, Guengerich FP, Marnett L, Tretyakova N. Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. The Journal of Biological Chemistry. 287: 38800-11. PMID 22977231 DOI: 10.1074/Jbc.M112.396788 |
0.346 |
|
2012 |
Zhao L, Pence MG, Christov PP, Wawrzak Z, Choi JY, Rizzo CJ, Egli M, Guengerich FP. Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases. The Journal of Biological Chemistry. 287: 35516-26. PMID 22910910 DOI: 10.1074/Jbc.M112.403253 |
0.334 |
|
2012 |
Lim S, Song I, Guengerich FP, Choi JY. Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). Chemical Research in Toxicology. 25: 1699-707. PMID 22793782 DOI: 10.1021/Tx300168P |
0.34 |
|
2012 |
Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP. Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. The Journal of Biological Chemistry. 287: 29554-67. PMID 22773874 DOI: 10.1074/Jbc.M112.390047 |
0.744 |
|
2012 |
Wang K, Guengerich FP. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. Chemical Research in Toxicology. 25: 1740-51. PMID 22734839 DOI: 10.1021/Tx3001994 |
0.411 |
|
2012 |
Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chemical Research in Toxicology. 25: 1652-61. PMID 22721435 DOI: 10.1021/Tx300113E |
0.341 |
|
2012 |
Cho SH, Guengerich FP. Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. Chemical Research in Toxicology. 25: 1522-30. PMID 22670845 DOI: 10.1021/Tx3002109 |
0.4 |
|
2012 |
Xiao Y, Guengerich FP. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. Journal of Lipid Research. 53: 1610-7. PMID 22591743 DOI: 10.1194/Jlr.M027185 |
0.413 |
|
2012 |
Rendic S, Guengerich FP. Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. Current Drug Metabolism. 13: 787-814. PMID 22571481 DOI: 10.2174/138920012800840356 |
0.347 |
|
2012 |
Rendic S, Guengerich FP. Contributions of human enzymes in carcinogen metabolism. Chemical Research in Toxicology. 25: 1316-83. PMID 22531028 DOI: 10.1021/Tx300132K |
0.417 |
|
2012 |
Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP. Replication of N2,3-ethenoguanine by DNA polymerases. Angewandte Chemie (International Ed. in English). 51: 5466-9. PMID 22488769 DOI: 10.1002/Anie.201109004 |
0.368 |
|
2012 |
Guengerich FP. Introduction: use of radioactive compounds in drug discovery and development. Chemical Research in Toxicology. 25: 511-2. PMID 22324508 DOI: 10.1021/Tx3000522 |
0.321 |
|
2012 |
Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Chemical Research in Toxicology. 25: 274-6. PMID 22268628 DOI: 10.1021/Tx300009J |
0.594 |
|
2012 |
Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR. Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. The Journal of Biological Chemistry. 287: 10613-22. PMID 22262854 DOI: 10.1074/Jbc.M111.323501 |
0.358 |
|
2012 |
Cho SH, Guengerich FP. Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. Chemical Research in Toxicology. 25: 706-12. PMID 22181695 DOI: 10.1021/Tx200471X |
0.395 |
|
2012 |
Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 34: 66-74. PMID 21638641 DOI: 10.1002/bmb.2006.49403402066 |
0.718 |
|
2011 |
Chowdhury G, Guengerich FP. Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 7.16.1-11. PMID 22147421 DOI: 10.1002/0471142700.Nc0716S47 |
0.613 |
|
2011 |
Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. The Journal of Biological Chemistry. 286: 33021-8. PMID 21813643 DOI: 10.1074/Jbc.M111.282434 |
0.428 |
|
2011 |
Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. The Journal of Biological Chemistry. 286: 31180-93. PMID 21784862 DOI: 10.1074/Jbc.M111.258038 |
0.375 |
|
2011 |
Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA. Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. Chemical Research in Toxicology. 24: 1223-30. PMID 21766881 DOI: 10.1021/Tx200080B |
0.464 |
|
2011 |
Guengerich FP, Cheng Q. Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology. Pharmacological Reviews. 63: 684-99. PMID 21737533 DOI: 10.1124/Pr.110.003525 |
0.408 |
|
2011 |
Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M. Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. Chemical Research in Toxicology. 24: 1327-37. PMID 21732699 DOI: 10.1021/Tx200218U |
0.383 |
|
2011 |
Salamanca-Pinzón SG, Guengerich FP. A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli. Protein Expression and Purification. 79: 231-6. PMID 21621619 DOI: 10.1016/J.Pep.2011.05.008 |
0.389 |
|
2011 |
Shinkyo R, Guengerich FP. Inhibition of human cytochrome P450 3A4 by cholesterol. The Journal of Biological Chemistry. 286: 18426-33. PMID 21471209 DOI: 10.1074/Jbc.M111.240457 |
0.386 |
|
2011 |
Xiao Y, Shinkyo R, Guengerich FP. Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 944-6. PMID 21430234 DOI: 10.1124/Dmd.111.039321 |
0.395 |
|
2011 |
Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chemical Research in Toxicology. 24: 287-9. PMID 21299192 DOI: 10.1021/Tx200005G |
0.588 |
|
2011 |
Akiyoshi T, Saito T, Murase S, Miyazaki M, Murayama N, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 724-8. PMID 21212239 DOI: 10.1124/Dmd.110.036780 |
0.302 |
|
2011 |
Shinkyo R, Guengerich FP. Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction. The Journal of Biological Chemistry. 286: 4632-43. PMID 21147774 DOI: 10.1074/Jbc.M110.193409 |
0.397 |
|
2011 |
Guengerich FP, Sohl CD, Chowdhury G. Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Archives of Biochemistry and Biophysics. 507: 126-34. PMID 20804723 DOI: 10.1016/J.Abb.2010.08.017 |
0.804 |
|
2011 |
Guengerich FP, Tang Z, Cheng Q, Salamanca-Pinzón SG. Approaches to deorphanization of human and microbial cytochrome P450 enzymes Biochimica Et Biophysica Acta. 1814: 139-145. PMID 20493973 DOI: 10.1016/J.Bbapap.2010.05.005 |
0.39 |
|
2011 |
Zhang H, Bren U, Kozekov ID, Rizzo CJ, Stec DF, Guengerich FP. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases F1000research. 2. DOI: 10.7490/F1000Research.864.1 |
0.331 |
|
2010 |
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chemical Research in Toxicology. 23: 1921-35. PMID 21053930 DOI: 10.1021/Tx100286D |
0.394 |
|
2010 |
Cheng Q, Lamb DC, Kelly SL, Lei L, Guengerich FP. Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction. Journal of the American Chemical Society. 132: 15173-5. PMID 20979426 DOI: 10.1021/Ja107801V |
0.403 |
|
2010 |
Eoff RL, Choi JY, Guengerich FP. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Journal of Nucleic Acids. 2010. PMID 20936119 DOI: 10.4061/2010/830473 |
0.349 |
|
2010 |
Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. Journal of Molecular Biology. 404: 34-44. PMID 20888339 DOI: 10.1016/J.Jmb.2010.09.015 |
0.301 |
|
2010 |
Cho SH, Loecken EM, Guengerich FP. Mutagenicity of a glutathione conjugate of butadiene diepoxide. Chemical Research in Toxicology. 23: 1544-6. PMID 20879737 DOI: 10.1021/Tx100304F |
0.768 |
|
2010 |
Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1013-8. PMID 20823515 DOI: 10.1107/S1744309110029374 |
0.337 |
|
2010 |
Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angewandte Chemie (International Ed. in English). 49: 7481-5. PMID 20814997 DOI: 10.1002/Anie.201003168 |
0.367 |
|
2010 |
Tang Z, Guengerich FP. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Analytical Chemistry. 82: 7706-12. PMID 20795636 DOI: 10.1021/Ac1015497 |
0.303 |
|
2010 |
Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 49: 8415-24. PMID 20726503 DOI: 10.1021/Bi1009024 |
0.325 |
|
2010 |
Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ. Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chemical Research in Toxicology. 23: 1330-41. PMID 20578729 DOI: 10.1021/Tx100082E |
0.331 |
|
2010 |
Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, et al. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research. 20: 1020-36. PMID 20538623 DOI: 10.1101/Gr.103341.109 |
0.392 |
|
2010 |
Chowdhury G, Murayama N, Okada Y, Uno Y, Shimizu M, Shibata N, Guengerich FP, Yamazaki H. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. Chemical Research in Toxicology. 23: 1018-24. PMID 20443640 DOI: 10.1021/Tx900367P |
0.654 |
|
2010 |
Sohl CD, Guengerich FP. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. The Journal of Biological Chemistry. 285: 17734-43. PMID 20385561 DOI: 10.1074/Jbc.M110.123711 |
0.735 |
|
2010 |
Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Chemical Research in Toxicology. 23: 1076-88. PMID 20377178 DOI: 10.1021/Tx100053N |
0.65 |
|
2010 |
Robert C, Wilson CS, Guengerich FP, Arreto CD. Evolution of the scientific literature of cytochrome P450 from 1977 to 2008. Current Drug Metabolism. 11: 162-70. PMID 20359288 DOI: 10.2174/138920010791110845 |
0.313 |
|
2010 |
Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion. Biochemistry. 49: 2615-26. PMID 20201499 DOI: 10.1021/Bi901516D |
0.312 |
|
2010 |
Chowdhury G, Calcutt MW, Guengerich FP. Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps. The Journal of Biological Chemistry. 285: 8031-44. PMID 20061389 DOI: 10.1074/Jbc.M109.088039 |
0.663 |
|
2010 |
Zhang H, Guengerich FP. Effect of N2-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W Journal of Molecular Biology. 395: 1007-1018. PMID 19969000 DOI: 10.1016/J.Jmb.2009.11.071 |
0.38 |
|
2010 |
Sangar MC, Anandatheerthavarada HK, Martin MV, Guengerich FP, Avadhani NG. Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting. Molecular Genetics and Metabolism. 99: 90-7. PMID 19781968 DOI: 10.1016/J.Ymgme.2009.08.009 |
0.32 |
|
2009 |
Guengerich FP. Cataloging the Repertoire of Nature's Blowtorch, P450 Chemistry and Biology. 16: 1215-1216. PMID 20064429 DOI: 10.1016/J.Chembiol.2009.12.002 |
0.349 |
|
2009 |
Tang Z, Salamanca-Pinzón SG, Wu ZL, Xiao Y, Guengerich FP. Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. Archives of Biochemistry and Biophysics. 494: 86-93. PMID 19932081 DOI: 10.1016/J.Abb.2009.11.017 |
0.385 |
|
2009 |
Nguyen LP, Hsu EL, Chowdhury G, Dostalek M, Guengerich FP, Bradfield CA. D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Chemical Research in Toxicology. 22: 1897-904. PMID 19860415 DOI: 10.1021/Tx900043S |
0.601 |
|
2009 |
Chowdhury G, Dostalek M, Hsu EL, Nguyen LP, Stec DF, Bradfield CA, Guengerich FP. Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. Chemical Research in Toxicology. 22: 1905-12. PMID 19860413 DOI: 10.1021/Tx9000418 |
0.598 |
|
2009 |
Zhang H, Beckman JW, Guengerich FP. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation Journal of Biological Chemistry. 284: 35144-35153. PMID 19837980 DOI: 10.1074/Jbc.M109.067397 |
0.378 |
|
2009 |
Deweese JE, Guengerich FP, Burgin AB, Osheroff N. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry. 48: 8940-7. PMID 19697956 DOI: 10.1021/Bi900875C |
0.305 |
|
2009 |
Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nature Protocols. 4: 1258-61. PMID 19661996 DOI: 10.1038/Nprot.2009.123 |
0.739 |
|
2009 |
Sohl CD, Cheng Q, Guengerich FP. Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Nature Protocols. 4: 1252-7. PMID 19661995 DOI: 10.1038/Nprot.2009.122 |
0.741 |
|
2009 |
Guengerich FP, Martin MV, Sohl CD, Cheng Q. Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Nature Protocols. 4: 1245-51. PMID 19661994 DOI: 10.1038/Nprot.2009.121 |
0.733 |
|
2009 |
Zhang H, Bren U, Kozekov ID, Rizzo CJ, Stec DF, Guengerich FP. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Journal of Molecular Biology. 392: 251-69. PMID 19607842 DOI: 10.1016/J.Jmb.2009.07.019 |
0.361 |
|
2009 |
Nagashima S, Shimizu M, Yano H, Murayama N, Kumai T, Kobayashi S, Guengerich FP, Yamazaki H. Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors Drug Metabolism and Pharmacokinetics. 24: 218-225. PMID 19571433 DOI: 10.2133/Dmpk.24.218 |
0.314 |
|
2009 |
Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chemical Research in Toxicology. 22: 1325-1333. PMID 19563207 DOI: 10.1021/Tx900127S |
0.372 |
|
2009 |
Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP. Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis Journal of Biological Chemistry. 284: 24425-24431. PMID 19561069 DOI: 10.1074/Jbc.M109.011320 |
0.404 |
|
2009 |
Wu ZL, Qiao J, Zhang ZG, Guengerich FP, Liu Y, Pei XQ. Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression. Biotechnology Letters. 31: 1589-93. PMID 19557307 DOI: 10.1007/S10529-009-0059-5 |
0.364 |
|
2009 |
Irimia A, Eoff RL, Guengerich FP, Egli M. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. The Journal of Biological Chemistry. 284: 22467-80. PMID 19542228 DOI: 10.1074/Jbc.M109.003905 |
0.363 |
|
2009 |
Eoff RL, Sanchez-Ponce R, Guengerich FP. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 284: 21090-9. PMID 19515847 DOI: 10.1074/Jbc.M109.009506 |
0.309 |
|
2009 |
Chowdhury G, Guengerich FP. Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. Chemical Research in Toxicology. 22: 1310-9. PMID 19496605 DOI: 10.1021/Tx900115Z |
0.622 |
|
2009 |
Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 48: 7079-88. PMID 19492857 DOI: 10.1021/Bi9003588 |
0.385 |
|
2009 |
Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek M, Guengerich FP, Avadhani NG. Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism. The Febs Journal. 276: 3440-53. PMID 19438707 DOI: 10.1111/J.1742-4658.2009.07067.X |
0.331 |
|
2009 |
Christov PP, Angel KC, Guengerich FP, Rizzo CJ. Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Chemical Research in Toxicology. 22: 1086-95. PMID 19397282 DOI: 10.1021/Tx900047C |
0.334 |
|
2009 |
Choi JY, Lim S, Eoff RL, Guengerich FP. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Journal of Molecular Biology. 389: 264-74. PMID 19376129 DOI: 10.1016/J.Jmb.2009.04.023 |
0.352 |
|
2009 |
Loecken EM, Dasari S, Hill S, Tabb DL, Guengerich FP. The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. Chemical Research in Toxicology. 22: 1069-76. PMID 19364102 DOI: 10.1021/Tx900037U |
0.785 |
|
2009 |
Tang Z, Martin MV, Guengerich FP. Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. Analytical Chemistry. 81: 3071-8. PMID 19301915 DOI: 10.1021/Ac900021A |
0.422 |
|
2009 |
Brown KL, Bren U, Stone MP, Guengerich FP. Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis. Chemical Research in Toxicology. 22: 913-7. PMID 19301826 DOI: 10.1021/Tx900002G |
0.36 |
|
2009 |
Knutson CG, Rubinson EH, Akingbade D, Anderson CS, Stec DF, Petrova KV, Kozekov ID, Guengerich FP, Rizzo CJ, Marnett LJ. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Biochemistry. 48: 800-9. PMID 19132922 DOI: 10.1021/Bi801654J |
0.366 |
|
2009 |
Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Biochemistry. 48: 471-80. PMID 19108641 DOI: 10.1021/Bi801591A |
0.338 |
|
2009 |
Zhang Z, Liu Y, Guengerich FP, Matse JH, Chen J, Wu Z. Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries Journal of Biotechnology. 139: 12-18. PMID 18984015 DOI: 10.1016/J.Jbiotec.2008.09.010 |
0.394 |
|
2009 |
Okada Y, Murayama N, Yanagida C, Shimizu M, Guengerich FP, Yamazaki H. Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5. Drug Metabolism and Disposition. 37: 18-23. PMID 18948377 DOI: 10.1124/Dmd.108.024679 |
0.436 |
|
2008 |
Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Chemical Research in Toxicology. 21: 2313-23. PMID 19548353 DOI: 10.1021/Tx8002998 |
0.386 |
|
2008 |
Beckman JW, Wang Q, Guengerich FP. Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. The Journal of Biological Chemistry. 283: 36711-23. PMID 18984592 DOI: 10.1074/Jbc.M806785200 |
0.334 |
|
2008 |
Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 47: 10892-903. PMID 18803403 DOI: 10.1021/Bi8008664 |
0.639 |
|
2008 |
Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2. Chemical Research in Toxicology. 21: 1795-805. PMID 18693701 DOI: 10.1021/Tx8001466 |
0.326 |
|
2008 |
Miyazaki M, Nakamura K, Fujita Y, Guengerich FP, Horiuchi R, Yamamoto K. Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone Drug Metabolism and Disposition. 36: 2287-2291. PMID 18669585 DOI: 10.1124/Dmd.108.021816 |
0.375 |
|
2008 |
Isin EM, Guengerich FP. Substrate binding to cytochromes P450 Analytical and Bioanalytical Chemistry. 392: 1019-1030. PMID 18622598 DOI: 10.1007/S00216-008-2244-0 |
0.382 |
|
2008 |
Choi JY, Guengerich FP. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1 Journal of Biological Chemistry. 283: 23645-23655. PMID 18591245 DOI: 10.1074/Jbc.M801686200 |
0.373 |
|
2008 |
Stark K, Wu Z, Bartleson CJ, Guengerich FP. mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1 Drug Metabolism and Disposition. 36: 1930-1937. PMID 18541694 DOI: 10.1124/Dmd.108.022020 |
0.387 |
|
2008 |
Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. The Journal of Biological Chemistry. 283: 17147-57. PMID 18442974 DOI: 10.1074/Jbc.M802447200 |
0.365 |
|
2008 |
Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical Research in Toxicology. 21: 1134-42. PMID 18416522 DOI: 10.1021/Tx7004458 |
0.339 |
|
2008 |
Isin EM, Sohl CD, Eoff RL, Guengerich FP. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Archives of Biochemistry and Biophysics. 473: 69-75. PMID 18328798 DOI: 10.1016/J.Abb.2008.02.033 |
0.722 |
|
2008 |
Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. The Journal of Biological Chemistry. 283: 7293-308. PMID 18187423 DOI: 10.1074/Jbc.M709783200 |
0.744 |
|
2008 |
Loecken EM, Guengerich FP. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Chemical Research in Toxicology. 21: 453-8. PMID 18163542 DOI: 10.1021/Tx7003618 |
0.799 |
|
2008 |
Guengerich FP. Cytochrome P450 and chemical toxicology Chemical Research in Toxicology. 21: 70-83. PMID 18052394 DOI: 10.1021/Tx700079Z |
0.387 |
|
2008 |
Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH. Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. Protein Expression and Purification. 57: 188-200. PMID 18032064 DOI: 10.1016/J.Pep.2007.10.010 |
0.529 |
|
2008 |
Chowdhury G, Guengerich FP. Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry Angewandte Chemie - International Edition. 47: 381-384. PMID 18022988 DOI: 10.1002/Anie.200703942 |
0.601 |
|
2008 |
Dimitri A, Goodenough AK, Guengerich FP, Broyde S, Scicchitano DA. Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. Journal of Molecular Biology. 375: 353-66. PMID 18022639 DOI: 10.1016/J.Jmb.2007.10.057 |
0.327 |
|
2007 |
Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 18: 504-12. PMID 18006294 DOI: 10.1016/J.Copbio.2007.09.010 |
0.304 |
|
2007 |
Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M. Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. The Journal of Biological Chemistry. 282: 36421-33. PMID 17951245 DOI: 10.1074/Jbc.M707267200 |
0.355 |
|
2007 |
Shanmugam G, Goodenough AK, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6. Chemical Research in Toxicology. 20: 1601-11. PMID 17941687 DOI: 10.1021/Tx7001788 |
0.324 |
|
2007 |
Guengerich FP. Mechanisms of cytochrome P450 substrate oxidation: MiniReview Journal of Biochemical and Molecular Toxicology. 21: 163-168. PMID 17936929 DOI: 10.1002/Jbt.20174 |
0.387 |
|
2007 |
Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Chemical Research in Toxicology. 20: 1594-600. PMID 17907789 DOI: 10.1021/Tx700125P |
0.376 |
|
2007 |
Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Molecular Pharmacology. 72: 1419-24. PMID 17898314 DOI: 10.1124/Mol.107.040238 |
0.421 |
|
2007 |
Stark K, Guengerich FP. Characterization of orphan human cytochromes P450 Drug Metabolism Reviews. 39: 627-637. PMID 17786643 DOI: 10.1080/03602530701467708 |
0.409 |
|
2007 |
Amunom I, Stephens LJ, Tamasi V, Cai J, Pierce WM, Conklin DJ, Bhatnagar A, Srivastava S, Martin MV, Guengerich FP, Prough RA. Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Archives of Biochemistry and Biophysics. 464: 187-96. PMID 17599801 DOI: 10.1016/J.Abb.2007.05.019 |
0.398 |
|
2007 |
Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP. Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 282: 19831-43. PMID 17468100 DOI: 10.1074/Jbc.M702290200 |
0.306 |
|
2007 |
Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP. Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). The Journal of Biological Chemistry. 282: 17486-500. PMID 17446171 DOI: 10.1074/Jbc.M700863200 |
0.395 |
|
2007 |
Sanchez-Ponce R, Guengerich FP. Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes. Analytical Chemistry. 79: 3355-62. PMID 17408243 DOI: 10.1021/Ac0622781 |
0.317 |
|
2007 |
Eoff RL, Angel KC, Egli M, Guengerich FP. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. The Journal of Biological Chemistry. 282: 13573-84. PMID 17337730 DOI: 10.1074/Jbc.M700656200 |
0.337 |
|
2007 |
Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP. Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors. Chemical Research in Toxicology. 20: 489-496. PMID 17291012 DOI: 10.1021/Tx600299P |
0.395 |
|
2007 |
Isin EM, Guengerich FP. Complex reactions catalyzed by cytochrome P450 enzymes Biochimica Et Biophysica Acta - General Subjects. 1770: 314-329. PMID 17239540 DOI: 10.1016/J.Bbagen.2006.07.003 |
0.394 |
|
2007 |
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Chemical Research in Toxicology. 20: 155-63. PMID 17226938 DOI: 10.1021/Tx600257G |
0.378 |
|
2007 |
Isin EM, Guengerich FP. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 Journal of Biological Chemistry. 282: 6863-6874. PMID 17200113 DOI: 10.1074/Jbc.M610346200 |
0.378 |
|
2007 |
Butler BF, Palamanda J, Nomeir AA, Guengerich FP, Furge LL. Inhibition of Human Cytochrome P450 2D6 by Schering 66712 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A670-A |
0.716 |
|
2006 |
Stover JS, Chowdhury G, Zang H, Guengerich FP, Rizzo CJ. Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Chemical Research in Toxicology. 19: 1506-17. PMID 17112239 DOI: 10.1021/Tx0601455 |
0.624 |
|
2006 |
Oda Y, Totsuka Y, Wakabayashi K, Guengerich FP, Shimada T. Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. Mutagenesis. 21: 411-416. PMID 17067997 DOI: 10.1093/Mutage/Gel047 |
0.363 |
|
2006 |
Choi JY, Chowdhury G, Zang H, Angel KC, Vu CC, Peterson LA, Guengerich FP. Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. The Journal of Biological Chemistry. 281: 38244-56. PMID 17050527 DOI: 10.1074/Jbc.M608369200 |
0.609 |
|
2006 |
Guengerich FP. A malleable catalyst dominates the metabolism of drugs Proceedings of the National Academy of Sciences of the United States of America. 103: 13565-13566. PMID 16954196 DOI: 10.1073/Pnas.0606333103 |
0.353 |
|
2006 |
Watanabe K, Guengerich FP. Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Chemical Research in Toxicology. 19: 1091-1096. PMID 16918250 DOI: 10.1021/Tx060087N |
0.338 |
|
2006 |
Lamb DC, Guengerich FP, Kelly SL, Waterman MR. Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery. Expert Opinion On Drug Metabolism & Toxicology. 2: 27-40. PMID 16863466 DOI: 10.1517/17425255.2.1.27 |
0.316 |
|
2006 |
Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP. Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. The Journal of Biological Chemistry. 281: 25297-306. PMID 16835218 DOI: 10.1074/Jbc.M605699200 |
0.618 |
|
2006 |
Choi JY, Zang H, Angel KC, Kozekov ID, Goodenough AK, Rizzo CJ, Guengerich FP. Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chemical Research in Toxicology. 19: 879-86. PMID 16780368 DOI: 10.1021/Tx060051V |
0.34 |
|
2006 |
Zang H, Chowdhury G, Angel KC, Harris TM, Guengerich FP. Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. Chemical Research in Toxicology. 19: 859-67. PMID 16780366 DOI: 10.1021/Tx060056S |
0.639 |
|
2006 |
Choi J, Angel KC, Guengerich FP. Translesion Synthesis across Bulky N2-Alkyl Guanine DNA Adducts by Human DNA Polymerase κ Journal of Biological Chemistry. 281: 21062-21072. PMID 16751196 DOI: 10.1074/Jbc.M602246200 |
0.391 |
|
2006 |
Bren U, Zupan M, Guengerich FP, Mavri J. Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine. Journal of Organic Chemistry. 71: 4078-4084. PMID 16709046 DOI: 10.1021/Jo060098L |
0.304 |
|
2006 |
Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. The Febs Journal. 273: 2223-31. PMID 16649998 DOI: 10.1111/j.1742-4658.2006.05235.x |
0.537 |
|
2006 |
Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity Aaps Journal. 8. PMID 16584116 DOI: 10.1208/Aapsj080112 |
0.351 |
|
2006 |
Wu ZL, Sohl CD, Shimada T, Guengerich FP. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Molecular Pharmacology. 69: 2007-14. PMID 16551781 DOI: 10.1124/Mol.106.023648 |
0.748 |
|
2006 |
Choi J, Guengerich FP. Kinetic Evidence for Inefficient and Error-prone Bypass across Bulky N2-Guanine DNA Adducts by Human DNA Polymerase ι Journal of Biological Chemistry. 281: 12315-12324. PMID 16527824 DOI: 10.1074/Jbc.M600112200 |
0.305 |
|
2006 |
Shimada T, Guengerich FP. Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons Chemical Research in Toxicology. 19: 288-294. PMID 16485905 DOI: 10.1021/Tx050291V |
0.387 |
|
2006 |
Isin EM, Guengerich FP. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 Journal of Biological Chemistry. 281: 9127-9136. PMID 16467307 DOI: 10.1074/Jbc.M511375200 |
0.365 |
|
2006 |
Guengerich FP. Interactions of carcinogen-bound DNA with individual DNA polymerases Chemical Reviews. 106: 420-452. PMID 16464013 DOI: 10.1021/Cr0404693 |
0.343 |
|
2006 |
Wu Z, Bartleson CJ, Ham AL, Guengerich FP. Heterologous expression, purification, and properties of human cytochrome P450 27C1. Archives of Biochemistry and Biophysics. 445: 138-146. PMID 16360114 DOI: 10.1016/J.Abb.2005.11.002 |
0.383 |
|
2006 |
Zang H, Irimia A, Choi JY, Angel KC, Loukachevitch LV, Egli M, Guengerich FP. Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 281: 2358-72. PMID 16306039 DOI: 10.1074/Jbc.M510889200 |
0.338 |
|
2006 |
Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction Biochemistry and Molecular Biology Education. 34: 66-74. DOI: 10.1002/Bmb.2006.49403402066 |
0.737 |
|
2005 |
Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Chemistry & Biodiversity. 2: 51-65. PMID 17191919 DOI: 10.1002/Cbdv.200490166 |
0.303 |
|
2005 |
Guengerich FP. Activation of alkyl halides by glutathione transferases Methods in Enzymology. 401: 342-353. PMID 16399396 DOI: 10.1016/S0076-6879(05)01021-9 |
0.372 |
|
2005 |
Josephy PD, Guengerich FP, Miners JO. "Phase I" and "Phase II" drug metabolism: Terminology that we should phase out? Drug Metabolism Reviews. 37: 575-580. PMID 16393885 DOI: 10.1080/03602530500251220 |
0.306 |
|
2005 |
Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ. Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. Chemical Research in Toxicology. 18: 1701-14. PMID 16300379 DOI: 10.1021/Tx050141K |
0.382 |
|
2005 |
Zhao B, Guengerich FP, Voehler M, Waterman MR. Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. The Journal of Biological Chemistry. 280: 42188-97. PMID 16239228 DOI: 10.1074/Jbc.M509220200 |
0.344 |
|
2005 |
Wu ZL, Podust LM, Guengerich FP. Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis. The Journal of Biological Chemistry. 280: 41090-100. PMID 16215230 DOI: 10.1074/Jbc.M508182200 |
0.412 |
|
2005 |
Kim D, Wu ZL, Guengerich FP. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. The Journal of Biological Chemistry. 280: 40319-27. PMID 16207711 DOI: 10.1074/Jbc.M508171200 |
0.586 |
|
2005 |
Guengerich FP, Wu Z, Bartleson CJ. Function of human cytochrome P450s: characterization of the orphans. Biochemical and Biophysical Research Communications. 338: 465-469. PMID 16126164 DOI: 10.1016/J.Bbrc.2005.08.079 |
0.395 |
|
2005 |
Choi JY, Guengerich FP. Adduct size limits efficient and error-free bypass across bulky N 2-guanine DNA lesions by human DNA polymerase η Journal of Molecular Biology. 352: 72-90. PMID 16061253 DOI: 10.1016/J.Jmb.2005.06.079 |
0.321 |
|
2005 |
Guengerich FP. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase Archives of Biochemistry and Biophysics. 440: 204-211. PMID 16055078 DOI: 10.1016/J.Abb.2005.06.019 |
0.304 |
|
2005 |
Zang H, Fang Q, Pegg AE, Guengerich FP. Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 280: 30873-81. PMID 16000301 DOI: 10.1074/Jbc.M505283200 |
0.344 |
|
2005 |
Zang H, Goodenough AK, Choi JY, Irimia A, Loukachevitch LV, Kozekov ID, Angel KC, Rizzo CJ, Egli M, Guengerich FP. DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. The Journal of Biological Chemistry. 280: 29750-64. PMID 15965231 DOI: 10.1074/Jbc.M504756200 |
0.347 |
|
2005 |
Dueckershoff K, Unger M, Frank A, Gillam EMJ, Guengerich FP, Warzecha H. Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA. Febs Letters. 579: 2480-2484. PMID 15848192 DOI: 10.1016/J.Febslet.2005.02.082 |
0.34 |
|
2005 |
Kim D, Guengerich FP. Cytochrome P450 activation of arylamines and heterocyclic amines. Annual Review of Pharmacology and Toxicology. 45: 27-49. PMID 15822170 DOI: 10.1146/Annurev.Pharmtox.45.120403.100010 |
0.584 |
|
2005 |
VanderVeen LA, Druckova A, Riggins JN, Sorrells JL, Guengerich FP, Marnett LJ. Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct Biochemistry. 44: 5024-5033. PMID 15794640 DOI: 10.1021/Bi0472898 |
0.379 |
|
2005 |
Krauser JA, Guengerich FP. Cytochrome P450 3A4-catalyzed testosterone 6β-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps Journal of Biological Chemistry. 280: 19496-19506. PMID 15772082 DOI: 10.1074/Jbc.M501854200 |
0.352 |
|
2005 |
Vélez-Cruz R, Riggins JN, Daniels JS, Cai H, Guengerich FP, Marnett LJ, Osheroff N. Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells Biochemistry. 44: 3972-3981. PMID 15751973 DOI: 10.1021/Bi0478289 |
0.37 |
|
2005 |
Zang H, Harris TM, Guengerich FP. Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. Chemical Research in Toxicology. 18: 389-400. PMID 15720147 DOI: 10.1021/Tx049683C |
0.361 |
|
2005 |
Shimada T, Mernaugh RL, Guengerich FP. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5 enzymes Archives of Biochemistry and Biophysics. 435: 207-216. PMID 15680923 DOI: 10.1016/J.Abb.2004.12.008 |
0.431 |
|
2005 |
Yun CH, Kim KH, Calcutt MW, Guengerich FP. Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. The Journal of Biological Chemistry. 280: 12279-91. PMID 15665333 DOI: 10.1074/Jbc.M411019200 |
0.434 |
|
2005 |
Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, et al. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. The Journal of Biological Chemistry. 280: 11599-607. PMID 15659395 DOI: 10.1074/Jbc.M410933200 |
0.387 |
|
2005 |
Guengerich FP. Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation Archives of Biochemistry and Biophysics. 433: 369-378. PMID 15581593 DOI: 10.1016/J.Abb.2004.07.035 |
0.387 |
|
2005 |
Zang H, Harris TM, Guengerich FP. Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 280: 1165-78. PMID 15533946 DOI: 10.1074/Jbc.M405996200 |
0.379 |
|
2004 |
Kim D, Guengerich FP. Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. Archives of Biochemistry and Biophysics. 432: 102-8. PMID 15519301 DOI: 10.1016/J.Abb.2004.09.001 |
0.587 |
|
2004 |
Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH. Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Toxicology Letters. 153: 239-46. PMID 15451555 DOI: 10.1016/J.Toxlet.2004.04.017 |
0.437 |
|
2004 |
Krauser JA, Voehler M, Tseng L, Schefer AB, Godejohann M, Guengerich FP. Testosterone 1β‐hydroxylation by human cytochrome P450 3A4 Febs Journal. 271: 3962-3969. PMID 15373842 DOI: 10.1111/J.1432-1033.2004.04339.X |
0.349 |
|
2004 |
Guengerich FP, Krauser JA, Johnson WW. Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry. 43: 10775-10788. PMID 15311939 DOI: 10.1021/Bi0491393 |
0.408 |
|
2004 |
Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K. Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Chemical Research in Toxicology. 17: 1077-85. PMID 15310239 DOI: 10.1021/Tx049889D |
0.333 |
|
2004 |
Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 17: 972-82. PMID 15257623 DOI: 10.1021/Tx049897U |
0.368 |
|
2004 |
Guengerich FP. Cytochrome P450: What have we learned and what are the future issues? Drug Metabolism Reviews. 36: 159-197. PMID 15237850 DOI: 10.1081/Dmr-120033996 |
0.396 |
|
2004 |
Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L. Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry. 47: 3236-41. PMID 15163202 DOI: 10.1021/Jm030561B |
0.361 |
|
2004 |
Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I. Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metabolism and Disposition. 32: 666-674. PMID 15155559 DOI: 10.1124/Dmd.32.6.666 |
0.385 |
|
2004 |
Kim D, Kadlubar FF, Teitel CH, Guengerich FP. Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines. Chemical Research in Toxicology. 17: 529-36. PMID 15089095 DOI: 10.1021/Tx034267Y |
0.557 |
|
2004 |
Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A. Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes Molecular Pharmacology. 65: 934-943. PMID 15044623 DOI: 10.1124/Mol.65.4.934 |
0.366 |
|
2004 |
Choi JY, Guengerich FP. Analysis of the Effect of Bulk at N2-Alkylguanine DNA Adducts on Catalytic Efficiency and Fidelity of the Processive DNA Polymerases Bacteriophage T7 Exonuclease- and HIV-1 Reverse Transcriptase Journal of Biological Chemistry. 279: 19217-19229. PMID 14985330 DOI: 10.1074/Jbc.M313759200 |
0.328 |
|
2004 |
Kim D, Guengerich FP. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. Biochemistry. 43: 981-8. PMID 14744142 DOI: 10.1021/Bi035593F |
0.582 |
|
2004 |
Marsch GA, Botta S, Martin MV, McCormick WA, Guengerich FP. Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes. Chemical Research in Toxicology. 17: 45-54. PMID 14727918 DOI: 10.1021/Tx034156Z |
0.376 |
|
2004 |
Zhou H, Josephy PD, Kim D, Guengerich FP. Functional characterization of four allelic variants of human cytochrome P450 1A2. Archives of Biochemistry and Biophysics. 422: 23-30. PMID 14725854 DOI: 10.1016/J.Abb.2003.11.019 |
0.583 |
|
2004 |
Valadez JG, Guengerich FP. S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage Journal of Biological Chemistry. 279: 13435-13446. PMID 14715658 DOI: 10.1074/Jbc.M312358200 |
0.347 |
|
2004 |
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 279: 4250-9. PMID 14645247 DOI: 10.1074/Jbc.M311105200 |
0.404 |
|
2003 |
Guengerich FP. Cytochromes P450, drugs, and diseases Mol Interv. 3: 194-204. PMID 14993447 DOI: 10.1124/Mi.3.4.194 |
0.309 |
|
2003 |
Guengerich FP, McCormick WA, Wheeler JB. Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Chemical Research in Toxicology. 16: 1493-9. PMID 14615977 DOI: 10.1021/Tx034157R |
0.301 |
|
2003 |
Kiyotani K, Yamazaki H, Fujieda M, Iwano S, Matsumura K, Satarug S, Ujjin P, Shimada T, Guengerich FP, Parkinson A, Honda G, Nakagawa K, Ishizaki T, Kamataki T. Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). Pharmacogenetics. 13: 689-695. PMID 14583682 DOI: 10.1097/00008571-200311000-00005 |
0.317 |
|
2003 |
Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE. O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry. 42: 10965-70. PMID 12974631 DOI: 10.1021/Bi034937Z |
0.381 |
|
2003 |
Guengerich FP, Hanna IH, Martin MV, Gillam EM. Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. Biochemistry. 42: 1245-53. PMID 12564927 DOI: 10.1021/Bi027085W |
0.375 |
|
2003 |
Guengerich FP. Activation of dihaloalkanes by thiol-dependent mechanisms Journal of Biochemistry and Molecular Biology. 36: 20-27. PMID 12542971 DOI: 10.5483/Bmbrep.2003.36.1.020 |
0.348 |
|
2003 |
Yun CH, Lee HS, Lee HY, Yim SK, Kim KH, Kim E, Yea SS, Guengerich FP. Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin Toxicology Letters. 137: 143-150. PMID 12523956 DOI: 10.1016/S0378-4274(02)00397-1 |
0.412 |
|
2003 |
Guengerich FP. Cytochrome P450 oxidations in the generation of reactive electrophiles: Epoxidation and related reactions Archives of Biochemistry and Biophysics. 409: 59-71. PMID 12464245 DOI: 10.1016/S0003-9861(02)00415-0 |
0.378 |
|
2002 |
Bell-Parikh LC, Hosea NA, Martin MV, Guengerich FP. Purification of cytochrome P-450 enzymes. Current Protocols in Toxicology. Unit4.2. PMID 23045082 DOI: 10.1002/0471140856.tx0402s12 |
0.323 |
|
2002 |
Guengerich FP, Wheeler JB, Chun YJ, Kim D, Shimada T, Aryal P, Oda Y, Gillam EM. Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. Toxicology. 181: 261-4. PMID 12505322 DOI: 10.1016/S0300-483X(02)00293-7 |
0.578 |
|
2002 |
Kim D, Guengerich FP. Random mutagenesis by whole-plasmid PCR amplification. Methods in Molecular Biology (Clifton, N.J.). 192: 241-5. PMID 12494656 DOI: 10.1385/1-59259-177-9:241 |
0.474 |
|
2002 |
Guengerich FP. Rate-limiting steps in cytochorme P450 catalysis Biological Chemistry. 383: 1553-1564. PMID 12452431 DOI: 10.1515/BC.2002.175 |
0.312 |
|
2002 |
Turesky RJ, Guengerich FP, Guillouzo A, Langouët S. Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. Mutation Research. 506: 187-195. PMID 12351158 DOI: 10.1016/S0027-5107(02)00165-3 |
0.343 |
|
2002 |
Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Biochemistry. 41: 11025-34. PMID 12206675 DOI: 10.1021/Bi020341K |
0.369 |
|
2002 |
Liu L, Pegg AE, Williams KM, Guengerich FP. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 277: 37920-8. PMID 12151404 DOI: 10.1074/Jbc.M205548200 |
0.405 |
|
2002 |
Guengerich FP. Cytochrome P450 enzymes in the generation of commercial products Nature Reviews Drug Discovery. 1: 359-366. PMID 12120411 DOI: 10.1038/Nrd792 |
0.37 |
|
2002 |
Guengerich FP, Miller GP, Hanna IH, Sato H, Martin MV. Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps. The Journal of Biological Chemistry. 277: 33711-9. PMID 12093814 DOI: 10.1074/Jbc.M205146200 |
0.357 |
|
2002 |
Guengerich FP, Voehler M, Williams KM, Deng Z, Harris TM. Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine. Chemical Research in Toxicology. 15: 793-8. PMID 12067246 DOI: 10.1021/Tx0200055 |
0.339 |
|
2002 |
Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM. Reaction of aflatoxin B(1) oxidation products with lysine. Chemical Research in Toxicology. 15: 780-92. PMID 12067245 DOI: 10.1021/Tx010156S |
0.354 |
|
2002 |
Saparbaev M, Langouët S, Privezentzev CV, Guengerich FP, Cai H, Elder RH, Laval J. 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. The Journal of Biological Chemistry. 277: 26987-93. PMID 12016206 DOI: 10.1074/Jbc.M111100200 |
0.357 |
|
2002 |
Guengerich FP. Update information on human P450s Drug Metabolism Reviews. 34: 7-15. PMID 11996014 DOI: 10.1081/Dmr-120001386 |
0.316 |
|
2002 |
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expression and Purification. 24: 329-337. PMID 11922748 DOI: 10.1006/Prep.2001.1578 |
0.379 |
|
2002 |
Gillam EMJ, Guengerich FP. Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology Iubmb Life. 52: 271-277. PMID 11895075 DOI: 10.1080/152165401317291110 |
0.398 |
|
2002 |
Ueng YF, Jan WC, Lin LC, Chen T, Guengerich FP, Chen CF. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metabolism and Disposition. 30: 349-353. PMID 11854157 DOI: 10.1124/Dmd.30.3.349 |
0.377 |
|
2002 |
Woodside AM, Guengerich FP. Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Biochemistry. 41: 1039-50. PMID 11790128 DOI: 10.1021/Bi011496F |
0.794 |
|
2002 |
Woodside AM, Guengerich FP. Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Biochemistry. 41: 1027-38. PMID 11790127 DOI: 10.1021/Bi011495N |
0.772 |
|
2002 |
Anzenbacher P, Anzenbacherová E, Zuber R, Soucek P, Guengerich FP, Myers MJ, Farkell DE, Howard KD, Kawalek JC. Pig and minipig cytochromes P450 (multiple letters) Drug Metabolism and Disposition. 30: 100-102. PMID 11776951 DOI: 10.1124/Dmd.30.1.100 |
0.397 |
|
2001 |
Langouët S, Welti DH, Kerriguy N, Fay LB, Guengerich FP, Guillouzo A, Turesky RJ. Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes. Advances in Experimental Medicine and Biology. 500: 459-462. PMID 11764981 DOI: 10.1007/978-1-4615-0667-6_69 |
0.353 |
|
2001 |
Soucek P, Zuber R, Anzenbacherová E, Anzenbacher P, Guengerich FP. Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs Bmc Pharmacology. 1: 11-11. PMID 11737866 DOI: 10.1186/1471-2210-1-11 |
0.401 |
|
2001 |
Chun YJ, Kim S, Kim D, Lee SK, Guengerich FP. A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Research. 61: 8164-70. PMID 11719446 |
0.519 |
|
2001 |
Nakamura K, Martin MV, Guengerich FP. Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. Archives of Biochemistry and Biophysics. 395: 25-31. PMID 11673862 DOI: 10.1006/Abbi.2001.2569 |
0.387 |
|
2001 |
Hanna IH, Kim M, Guengerich FP. Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Archives of Biochemistry and Biophysics. 393: 255-261. PMID 11556812 DOI: 10.1006/Abbi.2001.2510 |
0.399 |
|
2001 |
Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T. Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 497: 223-233. PMID 11525925 DOI: 10.1016/S1383-5718(01)00254-6 |
0.383 |
|
2001 |
Hanna IH, Krauser JA, Cai H, Kim MS, Guengerich FP. Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. The Journal of Biological Chemistry. 276: 39553-61. PMID 11509577 DOI: 10.1074/Jbc.M106841200 |
0.416 |
|
2001 |
Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1176-82. PMID 11502724 |
0.324 |
|
2001 |
Yamazaki H, Shimada T, Martin MV, Guengerich FP. Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. The Journal of Biological Chemistry. 276: 30885-91. PMID 11413149 DOI: 10.1074/Jbc.M105011200 |
0.358 |
|
2001 |
Guengerich FP. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Chemical Research in Toxicology. 14: 611-650. PMID 11409933 DOI: 10.1021/Tx0002583 |
0.38 |
|
2001 |
Guengerich FP. Forging the links between metabolism and carcinogenesis Mutation Research - Reviews in Mutation Research. 488: 195-209. PMID 11397649 DOI: 10.1016/S1383-5742(01)00059-X |
0.381 |
|
2001 |
Oda Y, Aryal P, Terashita T, Gillam EM, Guengerich FP, Shimada T. Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutation Research. 492: 81-90. PMID 11377247 DOI: 10.1016/S1383-5718(01)00154-1 |
0.369 |
|
2001 |
Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis. 22: 943-50. PMID 11375903 DOI: 10.1093/Carcin/22.6.943 |
0.386 |
|
2001 |
Nakamura K, Hanna IH, Cai H, Nishimura Y, Williams KM, Guengerich FP. Coumarin substrates for cytochrome P450 2D6 fluorescence assays. Analytical Biochemistry. 292: 280-286. PMID 11355862 DOI: 10.1006/Abio.2001.5098 |
0.388 |
|
2001 |
Cai H, Guengerich FP. Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: Inactivation and sites of modification Chemical Research in Toxicology. 14: 451-458. PMID 11304134 DOI: 10.1021/tx0002280 |
0.31 |
|
2001 |
Yun CH, Miller GP, Guengerich FP. Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: Structure - Activity relationships and simulation of rate constants of individual steps in catalysis Biochemistry. 40: 4521-4530. PMID 11284709 DOI: 10.1021/bi002906n |
0.309 |
|
2001 |
and HC, Guengerich FP. Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions. Chemical Research in Toxicology. 14: 54-61. PMID 11170508 DOI: 10.1021/Tx000185N |
0.369 |
|
2001 |
Gautier J, Richoz J, Welti DH, Markovic J, Gremaud E, Guengerich FP, Turesky RJ. Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Chemical Research in Toxicology. 14: 34-45. PMID 11170506 DOI: 10.1021/tx000070j |
0.366 |
|
2000 |
Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM. What makes P450s work? Searches for answers with known and new P450s. Drug Metabolism Reviews. 32: 267-81. PMID 11139129 DOI: 10.1081/Dmr-100102334 |
0.594 |
|
2000 |
Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T. Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 472: 129-138. PMID 11113705 DOI: 10.1016/S1383-5718(00)00138-8 |
0.391 |
|
2000 |
Einolf HJ, Guengerich FP. Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis. The Journal of Biological Chemistry. 276: 3764-71. PMID 11110788 DOI: 10.1074/Jbc.M006696200 |
0.323 |
|
2000 |
Gillam EM, Notley LM, Cai H, De Voss JJ, Guengerich FP. Oxidation of indole by cytochrome P450 enzymes. Biochemistry. 39: 13817-24. PMID 11076521 DOI: 10.1021/bi001229u |
0.321 |
|
2000 |
Shimada T, Tsumura F, Gillam EMJ, Guengerich FP, Inoue K. Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Protein Expression and Purification. 20: 73-80. PMID 11035953 DOI: 10.1006/Prep.2000.1302 |
0.389 |
|
2000 |
Aryal P, Terashita T, Guengerich FP, Shimada T, Oda Y. Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. Environmental and Molecular Mutagenesis. 36: 121-6. PMID 11013410 DOI: 10.1002/1098-2280(2000)36:2<121::Aid-Em6>3.0.Co;2-P |
0.348 |
|
2000 |
Yun CH, Miller GP, Guengerich FP. Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants Biochemistry. 39: 11319-11329. PMID 10985777 DOI: 10.1021/Bi000869U |
0.424 |
|
2000 |
Hosea NA, Miller GP, Guengerich FP. Elucidation of distinct ligand binding sites for cytochrome P450 3A4 Biochemistry. 39: 5929-5939. PMID 10821664 DOI: 10.1021/Bi992765T |
0.38 |
|
2000 |
Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chemical Research in Toxicology. 13: 245-52. PMID 10775323 DOI: 10.1021/TX990189W |
0.725 |
|
2000 |
Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ. Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. The Journal of Biological Chemistry. 275: 11784-90. PMID 10766802 DOI: 10.1074/Jbc.275.16.11784 |
0.449 |
|
2000 |
Einolf HJ, Guengerich FP. Kinetic analysis of nucleotide incorporation by mammalian DNA polymerase delta. The Journal of Biological Chemistry. 275: 16316-22. PMID 10748013 DOI: 10.1074/Jbc.M001291200 |
0.353 |
|
2000 |
Hanna IH, Reed JR, Guengerich FP, Hollenberg PF. Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver. Archives of Biochemistry and Biophysics. 376: 206-16. PMID 10729207 DOI: 10.1006/Abbi.2000.1708 |
0.622 |
|
2000 |
Guengerich FP. Metabolism of chemical carcinogens Carcinogenesis. 21: 345-351. PMID 10688854 DOI: 10.1093/Carcin/21.3.345 |
0.347 |
|
2000 |
Shimada T, Tsumura F, Yamazaki H, Guengerich FP, Inoue K. Relationships Between Genetic Polymorphisms In Cyp2D6 And Cyp2E1 Genes And Liver Microsomal Drug Oxidation Activities Drug Metabolism and Pharmacokinetics. 15: 84-85. DOI: 10.2133/Dmpk.15.Supplement_84 |
0.357 |
|
2000 |
Upadhyaya P, Carmella SG, Guengerich F, Hecht SS. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues Carcinogenesis. 21: 1233-1238. DOI: 10.1093/Carcin/21.6.1233 |
0.329 |
|
2000 |
Sato H, Guengerich FP. Oxidation of 1,2,4,5-tetramethoxybenzene to a cation radical by cytochrome P450 [15] Journal of the American Chemical Society. 122: 8099-8100. DOI: 10.1021/Ja000838M |
0.348 |
|
2000 |
Guengerich FP. Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics Drug Development Research. 49: 4-16. DOI: 10.1002/(Sici)1098-2299(200001)49:1<4::Aid-Ddr2>3.0.Co;2-R |
0.302 |
|
1999 |
Lewis DFV, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP. Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Toxicology. 139: 53-79. PMID 10614688 DOI: 10.1016/S0300-483X(99)00098-0 |
0.377 |
|
1999 |
Gillam EM, Aguinaldo AM, Notley LM, Kim D, Mundkowski RG, Volkov AA, Arnold FH, Soucek P, DeVoss JJ, Guengerich FP. Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications. 265: 469-72. PMID 10558891 DOI: 10.1006/Bbrc.1999.1702 |
0.586 |
|
1999 |
Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 27: 1260-6. PMID 10534310 |
0.315 |
|
1999 |
Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP. Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. Mutation Research. 429: 199-208. PMID 10526205 DOI: 10.1016/S0027-5107(99)00120-7 |
0.358 |
|
1999 |
Guengerich FP, Parikh A, Turesky RJ, Josephy PD. Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. Mutation Research. 428: 115-24. PMID 10517985 DOI: 10.1016/S1383-5742(99)00039-3 |
0.439 |
|
1999 |
Turesky RJ, Constable A, Fay LB, Guengerich FP. Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2. Cancer Letters. 143: 109-12. PMID 10503887 DOI: 10.1016/S0304-3835(99)00137-8 |
0.448 |
|
1999 |
Chun YJ, Kim MY, Guengerich FP. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochemical and Biophysical Research Communications. 262: 20-4. PMID 10448061 DOI: 10.1006/Bbrc.1999.1152 |
0.405 |
|
1999 |
Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 20: 1607-13. PMID 10426814 DOI: 10.1093/Carcin/20.8.1607 |
0.4 |
|
1999 |
Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chemical Research in Toxicology. 12: 623-9. PMID 10409402 DOI: 10.1021/Tx990028S |
0.356 |
|
1999 |
Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y. Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. Mutation Research. 442: 113-20. PMID 10393280 DOI: 10.1016/S1383-5718(99)00070-4 |
0.408 |
|
1999 |
Yun C, Ahn T, Guengerich FP, Yamazaki H, Shimada T. Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. Archives of Biochemistry and Biophysics. 367: 81-88. PMID 10375402 DOI: 10.1006/Abbi.1999.1254 |
0.407 |
|
1999 |
Parikh A, Josephy PD, Guengerich FP. Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry. 38: 5283-9. PMID 10220313 DOI: 10.1021/bi990142+ |
0.308 |
|
1999 |
Nedelcheva V, Gut I, Souček P, Tichavská B, Týnkova L, Mráz J, Guengerich FP, Ingelman-Sundberg M. Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. Archives of Toxicology. 73: 33-40. PMID 10207612 DOI: 10.1007/S002040050583 |
0.366 |
|
1999 |
Furge LL, Guengerich FP. Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. Biochemistry. 38: 4818-25. PMID 10200170 DOI: 10.1021/BI982163U |
0.701 |
|
1999 |
Cai Y, Marcus C, Guengerich FP, Gelboin HV, Baird WM. Roles of cytochrome P450 1a1 and 1b1 in metabolic activation of dibenzo[a,l]pyrene by microsomes from the human mammary carcinoma cell line MCF-7 Polycyclic Aromatic Compounds. 16: 109-118. DOI: 10.1080/10406639908020578 |
0.396 |
|
1998 |
Guengerich FP, Hosea NA, Martin MV. Purification of cytochromes P450: products of bacterial recombinant expression systems. Methods in Molecular Biology (Clifton, N.J.). 107: 77-83. PMID 14577214 DOI: 10.1385/0-89603-519-0:77 |
0.399 |
|
1998 |
Guengerich FP, Martin MV. Purification of cytochromes P450. Rat and human hepatic forms Methods in Molecular Biology (Clifton, N.J.). 107: 35-53. PMID 14577211 DOI: 10.1385/0-89603-519-0:35 |
0.351 |
|
1998 |
Nunes MG, Desai D, Koehl W, Spratt TE, Guengerich FP, Amin S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study. Cancer Letters. 129: 131-8. PMID 9719453 DOI: 10.1016/S0304-3835(98)00049-4 |
0.373 |
|
1998 |
Turesky RJ, Constable A, Richoz J, Varga N, Markovic J, Martin MV, Guengerich FP. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chemical Research in Toxicology. 11: 925-36. PMID 9705755 DOI: 10.1021/tx980022n |
0.306 |
|
1998 |
Yun C, Ahn T, Guengerich FP. Conformational Change and Activation of Cytochrome P450 2B1 Induced by Salt and Phospholipid Archives of Biochemistry and Biophysics. 356: 229-238. PMID 9705213 DOI: 10.1006/Abbi.1998.0759 |
0.372 |
|
1998 |
Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Biochemical Pharmacology. 56: 243-51. PMID 9698079 DOI: 10.1016/S0006-2952(98)00133-6 |
0.383 |
|
1998 |
Guengerich FP, Shimada T. Activation of procarcinogens by human cytochrome P450 enzymes Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 400: 201-213. PMID 9685642 DOI: 10.1016/S0027-5107(98)00037-2 |
0.423 |
|
1998 |
Guengerich FP, Johnson WW, Shimada T, Ueng Y, Yamazaki H, Langouët S. Activation and detoxication of aflatoxin B1 Mutation Research. 402: 121-128. PMID 9675258 DOI: 10.1016/S0027-5107(97)00289-3 |
0.486 |
|
1998 |
Shen J, Moy JA, Green MD, Guengerich FP, Baron J. Immunohistochemical demonstration of beta-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells. Hepatology (Baltimore, Md.). 27: 1483-91. PMID 9620317 DOI: 10.1002/Hep.510270604 |
0.327 |
|
1998 |
Hosea NA, Guengerich FP. Oxidation of nonionic detergents by cytochrome P450 enzymes. Archives of Biochemistry and Biophysics. 353: 365-73. PMID 9606971 DOI: 10.1006/abbi.1998.0659 |
0.319 |
|
1998 |
Furge LL, Guengerich FP. Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. Biochemistry. 37: 3567-74. PMID 9521678 DOI: 10.1021/bi9722094 |
0.682 |
|
1998 |
Josephy PD, Evans DH, Parikh A, Guengerich FP. Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli. Chemical Research in Toxicology. 11: 70-4. PMID 9477228 DOI: 10.1021/tx970171q |
0.326 |
|
1998 |
Hosea NA, Guengerich FP. Oxidation of nonionic detergents by cytochrome P450 enzymes Faseb Journal. 12. DOI: 10.1006/Abbi.1998.0659 |
0.435 |
|
1998 |
Guengerich FP, Hosea NA. Cytochrome P450 3A4: Diversity of reactions, cooperativity, and component interactions Proceedings of the Western Pharmacology Society. 41: 267. |
0.318 |
|
1997 |
Guengerich FP. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species Chemico-Biological Interactions. 106: 161-182. PMID 9413544 DOI: 10.1016/S0009-2797(97)00068-9 |
0.439 |
|
1997 |
Shaw PM, Hosea NA, Thompson DV, Lenius JM, Guengerich FP. Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5. Archives of Biochemistry and Biophysics. 348: 107-15. PMID 9390180 DOI: 10.1006/Abbi.1997.0378 |
0.454 |
|
1997 |
Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H. Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Cancer Research. 57: 4757-64. PMID 9354437 |
0.322 |
|
1997 |
Guengerich FP, Parikh A. Expression of drug-metabolizing enzymes Current Opinion in Biotechnology. 8: 623-628. PMID 9353222 DOI: 10.1016/S0958-1669(97)80039-0 |
0.337 |
|
1997 |
Parikh A, Gillam EM, Guengerich FP. Drug metabolism by Escherichia coli expressing human cytochromes P450. Nature Biotechnology. 15: 784-8. PMID 9255795 DOI: 10.1038/nbt0897-784 |
0.312 |
|
1997 |
Yamazaki H, Gillam EMJ, Dong M, Johnson WW, Guengerich FP, Shimada T. Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Archives of Biochemistry and Biophysics. 342: 329-337. PMID 9186495 DOI: 10.1006/Abbi.1997.0125 |
0.409 |
|
1997 |
Furge LL, Guengerich FP. Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Biochemistry. 36: 6475-87. PMID 9174365 DOI: 10.1021/bi9627267 |
0.683 |
|
1997 |
Kelly JD, Eaton DL, Guengerich FP, Coulombe RA. Aflatoxin B1 Activation in Human Lung Toxicology and Applied Pharmacology. 144: 88-95. PMID 9169073 DOI: 10.1006/Taap.1997.8117 |
0.339 |
|
1997 |
Anderson KE, Hammons GJ, Kadlubar FF, Potter JD, Kaderlik KR, Ilett KF, Minchin RF, Teitel CH, Chou HC, Martin MV, Guengerich FP, Barone GW, Lang NP, Peterson LA. Metabolic activation of aromatic amines by human pancreas. Carcinogenesis. 18: 1085-92. PMID 9163700 DOI: 10.1093/Carcin/18.5.1085 |
0.361 |
|
1997 |
Shimada T, Gillam EMJ, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1 Drug Metabolism and Disposition. 25: 617-622. PMID 9152602 |
0.354 |
|
1997 |
Parikh A, Guengerich FP. Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:Rat NADPH-cytochrome P450 reductase fusion protein Protein Expression and Purification. 9: 346-354. PMID 9126606 DOI: 10.1006/Prep.1997.0721 |
0.44 |
|
1997 |
Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 18: 851-4. PMID 9111224 DOI: 10.1093/Carcin/18.4.851 |
0.326 |
|
1997 |
Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP. Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes. Chemical Research in Toxicology. 10: 91-102. PMID 9074808 DOI: 10.1021/tx960064g |
0.33 |
|
1997 |
Guengerich FP, Vaz AD, Raner GN, Pernecky SJ, Coon MJ. Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. Molecular Pharmacology. 51: 147-51. PMID 9016357 DOI: 10.1124/Mol.51.1.147 |
0.595 |
|
1997 |
Ueng YF, Kuwabara T, Chun YJ, Guengerich FP. Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry. 36: 370-81. PMID 9003190 DOI: 10.1021/Bi962359Z |
0.406 |
|
1997 |
Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochemical Pharmacology. 53: 111-6. PMID 8960070 DOI: 10.1016/S0006-2952(96)00693-4 |
0.371 |
|
1997 |
Guengerich FP, Humphreys WG, Yun CH, Hammons GJ, Kadlubar FF, Seto Y, Okazaki O, Martin MV. Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues. Princess Takamatsu Symposia. 23: 78-84. PMID 8844798 |
0.351 |
|
1997 |
Shimada T, Inoue K, Shaw PM, Guengerich FP, Yamazaki H. Omeprazole Hydroxylation By Cyp2C19 And Cyp3A4: Prediction Towards Human Liver Activities Using The Data Of Recombinant P450 Enzymes Drug Metabolism and Pharmacokinetics. 12: 120-121. DOI: 10.2133/Dmpk.12.Supplement_120 |
0.389 |
|
1997 |
Guengerich FP, Johnson WW, Kim M, Müller M, Langouët S. O I.1 Chemistry of DNA-carcinogen adducts: Formation and biological effects Mutation Research. 379. DOI: 10.1016/S0027-5107(97)82613-9 |
0.339 |
|
1996 |
Mancy A, Dijol S, Poli S, Guengerich FP, Mansuy D. Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9 Biochemistry. 35: 16205-16212. PMID 8973193 DOI: 10.1021/Bi961950T |
0.351 |
|
1996 |
Yamazaki H, Johnson WW, Ueng Y, Shimada T, Guengerich FP. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. Journal of Biological Chemistry. 271: 27438-27444. PMID 8910324 DOI: 10.1074/Jbc.271.44.27438 |
0.405 |
|
1996 |
Guengerich FP, Yun CH, Macdonald TL. Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates. The Journal of Biological Chemistry. 271: 27321-9. PMID 8910308 DOI: 10.1074/Jbc.271.44.27321 |
0.34 |
|
1996 |
Müller M, Belas F, Ueno H, Guengerich FP. Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-a]Purine in DNA Modified by 2-Chloro-Oxirane Advances in Experimental Medicine and Biology. 387: 31-36. PMID 8794191 DOI: 10.1007/978-1-4757-9480-9_5 |
0.383 |
|
1996 |
Guengerich FP, Martin MV, Guo Z, Chun Y. Purification Of Functional Recombinant P450S From Bacteria Methods in Enzymology. 272: 35-44. PMID 8791760 DOI: 10.1016/S0076-6879(96)72006-2 |
0.371 |
|
1996 |
Guengerich FP, Johnson WW, Ueng YF, Yamazaki H, Shimada T. Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Environmental Health Perspectives. 104: 557-562. PMID 8781383 DOI: 10.1289/Ehp.96104S3557 |
0.327 |
|
1996 |
Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesthesia and Analgesia. 82: 167-72. PMID 8712396 DOI: 10.1097/00000539-199601000-00031 |
0.301 |
|
1996 |
Yamazaki H, Nakano M, Gillam EM, Bell LC, Guengerich FP, Shimada T. Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical Pharmacology. 52: 301-9. PMID 8694855 DOI: 10.1016/0006-2952(96)00208-0 |
0.306 |
|
1996 |
Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, Sutter TR. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1 Cancer Research. 56: 2979-2984. PMID 8674051 |
0.308 |
|
1996 |
Nakhgevany R, Bonsu O, Barber J, Mabrouk PA, Ueng YF, Bell LC, Guengerich FP. Preparation, purification, and spectrophotometric characterization of cytochrome P450 1A2 conjugated with polyethylene glycol monomethyl ether. Biochemical and Biophysical Research Communications. 222: 406-9. PMID 8670218 DOI: 10.1006/Bbrc.1996.0757 |
0.41 |
|
1996 |
Chun Y, Shimada T, Guengerich FP. Construction of a Human Cytochrome P450 1A1:Rat NADPH–Cytochrome P450 Reductase Fusion Protein cDNA and Expression inEscherichia coli,Purification, and Catalytic Properties of the Enzyme in Bacterial Cells and after Purification Archives of Biochemistry and Biophysics. 330: 48-58. PMID 8651703 DOI: 10.1006/Abbi.1996.0224 |
0.414 |
|
1996 |
Smith TJ, Guo Z, Guengerich FP, Yang CS. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. Carcinogenesis. 17: 809-13. PMID 8625495 DOI: 10.1093/Carcin/17.4.809 |
0.402 |
|
1996 |
Ingelman-Sundberg M, Hagbjörk AL, Ueng YF, Yamazaki H, Guengerich FP. High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge. Biochemical and Biophysical Research Communications. 221: 318-22. PMID 8619853 DOI: 10.1006/Bbrc.1996.0593 |
0.322 |
|
1996 |
Tateishi T, Wood AJ, Guengerich FP, Wood M. Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. Biochemical Pharmacology. 50: 1921-4. PMID 8615873 DOI: 10.1016/0006-2952(95)02088-8 |
0.332 |
|
1996 |
Dong M, Yamazaki H, Guo Z, Guengerich FP. Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics. 327: 11-19. PMID 8615680 DOI: 10.1006/Abbi.1996.0086 |
0.338 |
|
1996 |
Yamazaki H, Inoue K, Mimura M, Oda Y, Guengerich FP, Shimada T. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. Biochemical Pharmacology. 51: 313-9. PMID 8573198 DOI: 10.1016/0006-2952(95)02178-7 |
0.33 |
|
1996 |
Yamazaki H, Nakano M, Imai Y, Ueng Y, Guengerich FP, Shimada T. Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes Archives of Biochemistry and Biophysics. 325: 174-182. PMID 8561495 DOI: 10.1006/Abbi.1996.0022 |
0.316 |
|
1996 |
Werner M, Guo Z, Birner G, Dekant W, Guengerich FP. The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes. Chemical Research in Toxicology. 8: 917-23. PMID 8555406 DOI: 10.1021/tx00049a004 |
0.319 |
|
1996 |
Koehl W, Amin S, Staretz ME, Ueng YF, Yamazaki H, Tateishi T, Guengerich FP, Hecht SS. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes. Cancer Research. 56: 316-24. PMID 8542586 |
0.301 |
|
1996 |
Miller MS, Juchau MR, Guengerich FP, Nebert DW, Raucy JL. Drug Metabolic Enzymes in Developmental Toxicology Toxicological Sciences. 34: 165-175. DOI: 10.1093/Toxsci/34.2.165 |
0.325 |
|
1996 |
Koehl W, Amin S, Yamazaki H, Ueng Y, Tateishi T, Guengerich FP, Hecht SS. Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes Polycyclic Aromatic Compounds. 10: 59-66. DOI: 10.1080/10406639608034680 |
0.382 |
|
1996 |
Johnson WW, Harris aTM, Guengerich FP. Kinetics And Mechanism Of Hydrolysis Of Aflatoxin B1 Exo-8,9-Epoxide And Rearrangement Of The Dihydrodiol Journal of the American Chemical Society. 118: 8213-8220. DOI: 10.1021/Ja960525K |
0.378 |
|
1995 |
Pichard L, Curi-Pedrosa R, Bonfils C, Jacqz-Aigrain E, Domergue J, Joyeux H, Cosme J, Guengerich FP, Maurel P. Oxidative metabolism of lansoprazole by human liver cytochromes P450. Molecular Pharmacology. 47: 410-8. PMID 7870052 |
0.321 |
|
1995 |
Yun CH, Jeong HG, Jhoun JW, Guengerich FP. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis. 16: 1437-40. PMID 7788866 DOI: 10.1093/carcin/16.6.1437 |
0.316 |
|
1995 |
Ueng Y, Shimada T, Yamazaki H, Guengerich FP. Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology. 8: 218-225. PMID 7766804 DOI: 10.1021/Tx00044A006 |
0.321 |
|
1995 |
Bauer E, Guo Z, Ueng YF, Bell LC, Zeldin D, Guengerich FP. Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology. 8: 136-42. PMID 7703357 |
0.325 |
|
1995 |
Yamazaki H, Ueng Y, Shimada T, Guengerich FP. Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen Surrogates Biochemistry. 34: 8380-8389. PMID 7599128 DOI: 10.1021/Bi00026A020 |
0.305 |
|
1995 |
Guengerich FP, Thier R, Persmark M, Taylor JB, Pemble SE, Ketterer B. Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics. 5: S103-7. PMID 7581478 DOI: 10.1097/00008571-199512001-00010 |
0.33 |
|
1995 |
Thier R, Müller M, Taylor JB, Pemble SE, Ketterer B, Guengerich FP. Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. Chemical Research in Toxicology. 8: 465-72. PMID 7578934 DOI: 10.1021/Tx00045A019 |
0.336 |
|
1995 |
Shimada T, Yamazaki H, Guengerich FP. Metabolic Activation of Procarcinogens by Human Cytochrome P450 Enzymes in Microsomes of Adult and Fetal Livers and of Adult Lungs Drug Metabolism and Pharmacokinetics. 10: 126-129. DOI: 10.2133/Dmpk.10.Supplement_126 |
0.4 |
|
1994 |
Yamazaki H, Mimura M, Oda Y, Gonzalez FJ, el-Bayoumy K, Chae YH, Guengerich FP, Shimada T. Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. Carcinogenesis. 15: 465-70. PMID 8118930 DOI: 10.1093/Carcin/15.3.465 |
0.372 |
|
1994 |
Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. Archives of Biochemistry and Biophysics. 309: 168-77. PMID 8117105 DOI: 10.1006/Abbi.1994.1099 |
0.316 |
|
1994 |
Degawa M, Stern SJ, Martin MV, Guengerich FP, Fu PP, Ilett KF, Kaderlik RK, Kadlubar FF. Metabolic activation and carcinogen-DNA adduct detection in human larynx. Cancer Research. 54: 4915-9. PMID 8069857 |
0.341 |
|
1994 |
Guo Z, Gillam EM, Ohmori S, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. Archives of Biochemistry and Biophysics. 312: 436-46. PMID 8037457 DOI: 10.1006/Abbi.1994.1330 |
0.318 |
|
1994 |
Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. The Journal of Pharmacology and Experimental Therapeutics. 270: 414-23. PMID 8035341 |
0.307 |
|
1994 |
Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP. Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis. 15: 2523-9. PMID 7955101 DOI: 10.1093/Carcin/15.11.2523 |
0.306 |
|
1994 |
Kazakoff K, Iversen P, Lawson T, Baron J, Guengerich FP, Pour PM. Involvement of cytochrome P450 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa European Journal of Cancer. Part B: Oral Oncology. 30: 179-185. PMID 7920164 DOI: 10.1016/0964-1955(94)90088-4 |
0.391 |
|
1994 |
Mimura M, Baba T, Yamazaki H, Ohmori S, Inui Y, Gonzalez FJ, Guengerich FP, Shimada T. Characterization of cytochrome P-450 2B6 in human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 21: 1048-56. PMID 7905383 |
0.323 |
|
1994 |
Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 Journal of Human Genetics. 39: 337-343. PMID 7841444 DOI: 10.1007/Bf01874052 |
0.311 |
|
1994 |
Seto Y, Okazaki O, Guengerich FP. Mechanism Of N -Oxidation Reaction Catalyzed By Cytochrome P-450 Drug Metabolism and Pharmacokinetics. 9: 172-175. DOI: 10.2133/Dmpk.9.Supplement_172 |
0.369 |
|
1994 |
Iyer RS, Coles BF, Raney KD, Thier R, Guengerich FP, Harris TM. DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies Journal of the American Chemical Society. 116: 1603-1609. DOI: 10.1021/Ja00084A001 |
0.408 |
|
1993 |
Lopez Garcia MP, Dansette PM, Valadon P, Amar C, Beaune PH, Guengerich FP, Mansuy D. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. European Journal of Biochemistry. 213: 223-32. PMID 8477697 DOI: 10.1111/J.1432-1033.1993.Tb17752.X |
0.409 |
|
1993 |
Stern SJ, Degawa M, Martin MV, Guengerich FP, Kaderlik RK, Ilett KF, Breau R, McGhee M, Montague D, Lyn-Cook B. Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue. Journal of Cellular Biochemistry. Supplement. 17: 129-37. PMID 8412184 DOI: 10.1002/Jcb.240531018 |
0.392 |
|
1993 |
Ohmori S, Horie T, Guengerich FP, Kiuchi M, Kitada M. Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys. Archives of Biochemistry and Biophysics. 305: 405-13. PMID 8373178 DOI: 10.1006/abbi.1993.1439 |
0.31 |
|
1993 |
Gillam EM, Baba T, Kim BR, Ohmori S, Guengerich FP. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. Archives of Biochemistry and Biophysics. 305: 123-31. PMID 8342945 DOI: 10.1006/abbi.1993.1401 |
0.336 |
|
1993 |
Yamazaki H, Mimura M, Oda Y, Inui Y, Shiraga T, Iwasaki K, Guengerich FP, Shimada T. Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. Carcinogenesis. 14: 1271-8. PMID 8330339 DOI: 10.1093/Carcin/14.7.1271 |
0.386 |
|
1993 |
Meyer DJ, Coles B, Harris J, Gilmore KS, Raney K, Harris TM, Guengerich FP, Kensler TW, Ketterer B. Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties. Basic Life Sciences. 61: 171-9. PMID 8304929 DOI: 10.1007/978-1-4615-2984-2_16 |
0.325 |
|
1993 |
Guengerich FP, Gillam EM, Ohmori S, Sandhu P, Brian WR, Sari MA, Iwasaki M. Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity. Toxicology. 82: 21-37. PMID 8236276 DOI: 10.1016/0300-483x(93)90057-y |
0.307 |
|
1993 |
Yun CH, Okerholm RA, Guengerich FP. Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 21: 403-9. PMID 8100494 |
0.33 |
|
1993 |
Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Dna and Cell Biology. 12: 1-51. PMID 7678494 DOI: 10.1089/Dna.1993.12.1 |
0.559 |
|
1993 |
Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Ballet F, Feldmann G, Guengerich FP, Pessayre D. Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology. 104: 203-16. PMID 7678237 DOI: 10.1016/0016-5085(93)90853-5 |
0.334 |
|
1992 |
Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FP. Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. Chemical Research in Toxicology. 2: 114-2. PMID 2519710 DOI: 10.1021/Tx00008A008 |
0.391 |
|
1992 |
Knodell RG, Browne DG, Gwozdz GP, Brian WR, Guengerich FP. Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology. 101: 1680-91. PMID 1955133 DOI: 10.1016/0016-5085(91)90408-D |
0.426 |
|
1992 |
Yun CH, Shimada T, Guengerich FP. Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). Carcinogenesis. 13: 217-22. PMID 1740010 DOI: 10.1093/carcin/13.2.217 |
0.335 |
|
1992 |
Raney KD, Shimada T, Kim DH, Groopman JD, Harris TM, Guengerich FP. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chemical Research in Toxicology. 5: 202-10. PMID 1643250 DOI: 10.1021/Tx00026A009 |
0.564 |
|
1992 |
Csanády GA, Guengerich FP, Bond JA. Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis. 13: 1143-53. PMID 1638680 DOI: 10.1093/Carcin/13.7.1143 |
0.358 |
|
1992 |
Guengerich FP, Raney KD, Kim DH, Shimada T, Meyer DJ, Ketterer B, Harris TM. Oxidation and conjugation of aflatoxins by humans and experimental animals. Progress in Clinical and Biological Research. 374: 157-65. PMID 1620701 |
0.403 |
|
1992 |
Yamazaki H, Oda Y, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada T. Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). Carcinogenesis. 13: 979-85. PMID 1600620 DOI: 10.1093/Carcin/13.6.979 |
0.421 |
|
1992 |
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP. Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4. Molecular Pharmacology. 41: 975-80. PMID 1588928 |
0.349 |
|
1992 |
Guengerich FP. Human cytochrome P-450 enzymes. Life Sciences. 50: 1471-1478. PMID 1579042 DOI: 10.1016/0024-3205(92)90136-D |
0.419 |
|
1992 |
Guengerich FP. Metabolic activation of carcinogens. Pharmacology & Therapeutics. 54: 17-61. PMID 1528954 DOI: 10.1016/0163-7258(92)90050-A |
0.352 |
|
1992 |
Yun CH, Wood M, Wood AJ, Guengerich FP. Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Anesthesiology. 77: 467-74. PMID 1519785 DOI: 10.1097/00000542-199209000-00011 |
0.349 |
|
1992 |
Yamazaki H, Inui Y, Yun C, Guengerich FP, Shimada T. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes Carcinogenesis. 13: 1789-1794. PMID 1423839 DOI: 10.1093/Carcin/13.10.1789 |
0.446 |
|
1992 |
Shimada T, Yamazaki H, Mimura M, Guengerich FP. Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. Mutation Research. 284: 233-241. PMID 1281274 DOI: 10.1016/0027-5107(92)90007-O |
0.4 |
|
1992 |
Guengerich FP, Raney VM. Formation of etheno adducts of adenosine and cytidine from 1-halooxiranes. Evidence for a mechanism involving initial reaction with the endocyclic nitrogen atoms Journal of the American Chemical Society. 114: 1074-1080. DOI: 10.1021/Ja00029A041 |
0.32 |
|
1992 |
Kadlubar FF, Guengerich FP. Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens Chemosphere. 25: 201-204. DOI: 10.1016/0045-6535(92)90513-Q |
0.379 |
|
1991 |
Brian WR, Sari MA, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FP. Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry. 29: 11280-92. PMID 2271712 DOI: 10.1021/bi00503a018 |
0.331 |
|
1991 |
Guengerich FP, Shimada T, Bondon A, Macdonald TL. Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. Advances in Experimental Medicine and Biology. 283: 1-11. PMID 2068975 DOI: 10.1007/978-1-4684-5877-0_1 |
0.399 |
|
1991 |
Guengerich FP, Brian WR, Iwasaki M, Sari MA, Baeaernhielm C, Berntsson P. Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. Journal of Medicinal Chemistry. 34: 1838-1844. PMID 2061924 DOI: 10.1021/Jm00110A012 |
0.435 |
|
1991 |
Miranda CL, Reed RL, Guengerich FP, Buhler DR. Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver Carcinogenesis. 12: 515-519. PMID 2009596 DOI: 10.1093/Carcin/12.3.515 |
0.374 |
|
1991 |
Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. Dna and Cell Biology. 10: 1-14. PMID 1991046 DOI: 10.1089/Dna.1991.10.1 |
0.542 |
|
1991 |
Yamazaki H, Degawa M, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada T. Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes. Carcinogenesis. 12: 133-9. PMID 1988174 DOI: 10.1093/Carcin/12.1.133 |
0.393 |
|
1991 |
Guengerich FP. Molecular advances for the cytochrome P-450 superfamily Trends in Pharmacological Sciences. 12: 281-283. PMID 1949194 DOI: 10.1016/0165-6147(91)90574-C |
0.346 |
|
1991 |
Yun CH, Shimada T, Guengerich FP. Purification and characterization of human liver microsomal cytochrome P-450 2A6. Molecular Pharmacology. 40: 679-85. PMID 1944238 |
0.33 |
|
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