| Year |
Citation |
Score |
| 2023 |
Costanzi S, Stahr LG, Trivellin G, Stratakis CA. GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism. Journal of Molecular Graphics & Modelling. 127: 108676. PMID 38006624 DOI: 10.1016/j.jmgm.2023.108676 |
0.404 |
|
| 2018 |
Sagratini G, Buccioni M, Marucci G, Poggesi E, Skorski M, Costanzi S, Giardinà D. Chiral analogues of (+)-cyclazosin as potent α-adrenoceptor selective antagonist. Bioorganic & Medicinal Chemistry. PMID 29784274 DOI: 10.1016/J.Bmc.2018.05.023 |
0.337 |
|
| 2017 |
Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, ... ... Costanzi S, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/Pnas.1620645114 |
0.572 |
|
| 2016 |
Costanzi S, Skorski M, Deplano A, Habermehl B, Mendoza M, Wang K, Biederman M, Dawson J, Gao J. Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy. Journal of Molecular Graphics & Modelling. 70: 140-152. PMID 27723562 DOI: 10.1016/J.Jmgm.2016.10.004 |
0.41 |
|
| 2016 |
Costanzi S. Topological Analyses of Protein-Ligand Binding: a Network Approach. Current Protein & Peptide Science. 17: 37-40. PMID 26412793 DOI: 10.2174/1389203716666150923103934 |
0.308 |
|
| 2014 |
Jacobson KA, Costanzi S, Paoletta S. Computational studies to predict or explain G protein coupled receptor polypharmacology. Trends in Pharmacological Sciences. 35: 658-63. PMID 25458540 DOI: 10.1016/J.Tips.2014.10.009 |
0.708 |
|
| 2014 |
Costanzi S. Modeling G protein-coupled receptors in complex with biased agonists. Trends in Pharmacological Sciences. 35: 277-83. PMID 24793542 DOI: 10.1016/J.Tips.2014.04.004 |
0.498 |
|
| 2014 |
Micozzi D, Carpi FM, Pucciarelli S, Polzonetti V, Polidori P, Vilar S, Williams B, Costanzi S, Vincenzetti S. Human cytidine deaminase: a biochemical characterization of its naturally occurring variants. International Journal of Biological Macromolecules. 63: 64-74. PMID 24183806 DOI: 10.1016/J.Ijbiomac.2013.10.029 |
0.326 |
|
| 2014 |
Costanzi S, Wang K. The GPCR crystallography boom: providing an invaluable source of structural information and expanding the scope of homology modeling. Advances in Experimental Medicine and Biology. 796: 3-13. PMID 24158798 DOI: 10.1007/978-94-007-7423-0_1 |
0.457 |
|
| 2013 |
Jayasekara PS, Barrett MO, Ball CB, Brown KA, Kozma E, Costanzi S, Squarcialupi L, Balasubramanian R, Maruoka H, Jacobson KA. 4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor. Medchemcomm. 4: 1156-1165. PMID 26161252 DOI: 10.1039/C3Md00132F |
0.65 |
|
| 2013 |
Costanzi S. G protein-coupled receptors: computer-aided ligand discovery and computational structural analyses in the 2010s. In Silico Pharmacology. 1: 20. PMID 25505664 DOI: 10.1186/2193-9616-1-20 |
0.404 |
|
| 2013 |
Hu J, Hu K, Liu T, Stern MK, Mistry R, Challiss RA, Costanzi S, Wess J. Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation. The Journal of Biological Chemistry. 288: 34777-90. PMID 24133207 DOI: 10.1074/Jbc.M113.503714 |
0.433 |
|
| 2013 |
Costanzi S. Modeling G protein-coupled receptors and their interactions with ligands. Current Opinion in Structural Biology. 23: 185-90. PMID 23415855 DOI: 10.1016/J.Sbi.2013.01.008 |
0.515 |
|
| 2013 |
Vilar S, Costanzi S. Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands. Methods in Enzymology. 522: 263-78. PMID 23374190 DOI: 10.1016/B978-0-12-407865-9.00014-5 |
0.535 |
|
| 2013 |
Jacobson KA, Costanzi S, Deflorian F. Probing GPCR structure: adenosine and P2Y nucleotide receptors. Methods in Enzymology. 520: 199-217. PMID 23332701 DOI: 10.1016/B978-0-12-391861-1.00009-5 |
0.685 |
|
| 2013 |
Wei Q, Costanzi S, Balasubramanian R, Gao ZG, Jacobson KA. A2B adenosine receptor blockade inhibits growth of prostate cancer cells. Purinergic Signalling. 9: 271-80. PMID 23315335 DOI: 10.1007/S11302-012-9350-3 |
0.516 |
|
| 2013 |
Jayasekara PS, Barrett MO, Ball CB, Brown KA, Kozma E, Costanzi S, Squarcialupi L, Balasubramanian R, Maruoka H, Jacobson KA. 4-Alkyloxyimino-cytosine nucleotides: Tethering approaches to molecular probes for the P2Y6 receptor Medchemcomm. 4: 1156-1165. DOI: 10.1039/c3md00132f |
0.593 |
|
| 2012 |
Jacobson KA, Jayasekara MP, Costanzi S. Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes. Wiley Interdisciplinary Reviews. Membrane Transport and Signaling. 1. PMID 23336097 DOI: 10.1002/wmts.68 |
0.672 |
|
| 2012 |
Vilar S, Costanzi S. Predicting the biological activities through QSAR analysis and docking-based scoring. Methods in Molecular Biology (Clifton, N.J.). 914: 271-84. PMID 22976034 DOI: 10.1007/978-1-62703-023-6_16 |
0.394 |
|
| 2012 |
Costanzi S, Santhosh Kumar T, Balasubramanian R, Kendall Harden T, Jacobson KA. Virtual screening leads to the discovery of novel non-nucleotide P2Yâ‚ receptor antagonists. Bioorganic & Medicinal Chemistry. 20: 5254-61. PMID 22831801 DOI: 10.1016/J.Bmc.2012.06.044 |
0.682 |
|
| 2012 |
Jacobson KA, Costanzi S. New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors. Molecular Pharmacology. 82: 361-71. PMID 22695719 DOI: 10.1124/Mol.112.079335 |
0.667 |
|
| 2012 |
Costanzi S. Homology modeling of class a G protein-coupled receptors. Methods in Molecular Biology (Clifton, N.J.). 857: 259-79. PMID 22323225 DOI: 10.1007/978-1-61779-588-6_11 |
0.558 |
|
| 2012 |
Costanzi S, Vilar S. In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures. Journal of Computational Chemistry. 33: 561-72. PMID 22170280 DOI: 10.1002/Jcc.22893 |
0.531 |
|
| 2012 |
Hu J, Thor D, Zhou Y, Liu T, Wang Y, McMillin SM, Mistry R, Challiss RAJ, Costanzi S, Wess J. Structural aspects of M3 muscarinic acetylcholine receptor dimer formation and activation Faseb Journal. 26: 604-616. PMID 22031716 DOI: 10.1096/fj.11-191510 |
0.37 |
|
| 2011 |
Fatakia SN, Costanzi S, Chow CC. Molecular evolution of the transmembrane domains of G protein-coupled receptors. Plos One. 6: e27813. PMID 22132149 DOI: 10.1371/Journal.Pone.0027813 |
0.564 |
|
| 2011 |
McMillin SM, Heusel M, Liu T, Costanzi S, Wess J. Structural basis of M 3 muscarinic receptor dimer/oligomer formation Journal of Biological Chemistry. 286: 28584-28598. PMID 21685385 DOI: 10.1074/Jbc.M111.259788 |
0.57 |
|
| 2011 |
Wei Q, Costanzi S, Liu QZ, Gao ZG, Jacobson KA. Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells. Biochemical Pharmacology. 82: 418-25. PMID 21632028 DOI: 10.1016/J.Bcp.2011.05.013 |
0.622 |
|
| 2011 |
Costanzi S, Vilar S, Micozzi D, Carpi FM, Ferino G, Vita A, Vincenzetti S. Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening. Chemmedchem. 6: 1452-8. PMID 21598398 DOI: 10.1002/Cmdc.201100139 |
0.352 |
|
| 2011 |
Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA. Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor. Journal of Medicinal Chemistry. 54: 4018-33. PMID 21528910 DOI: 10.1021/Jm101591J |
0.731 |
|
| 2011 |
Jacobson KA, Deflorian F, Mishra S, Costanzi S. Pharmacochemistry of the platelet purinergic receptors. Purinergic Signalling. 7: 305-24. PMID 21484092 DOI: 10.1007/S11302-011-9216-0 |
0.737 |
|
| 2011 |
Vilar S, Karpiak J, Berk B, Costanzi S. In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor. Journal of Molecular Graphics & Modelling. 29: 809-17. PMID 21334234 DOI: 10.1016/J.Jmgm.2011.01.005 |
0.591 |
|
| 2011 |
Vilar S, Ferino G, Phatak SS, Berk B, Cavasotto CN, Costanzi S. Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models. Journal of Molecular Graphics & Modelling. 29: 614-23. PMID 21146435 DOI: 10.1016/J.Jmgm.2010.11.005 |
0.572 |
|
| 2010 |
Costanzi S. Modeling G Protein-Coupled Receptors: a Concrete Possibility. Chimica Oggi. 28: 26-31. PMID 21253444 |
0.38 |
|
| 2010 |
Micozzi D, Pucciarelli S, Carpi FM, Costanzi S, De Sanctis G, Polzonetti V, Natalini P, Santarelli IF, Vita A, Vincenzetti S. Role of tyrosine 33 residue for the stabilization of the tetrameric structure of human cytidine deaminase. International Journal of Biological Macromolecules. 47: 471-82. PMID 20637228 DOI: 10.1016/J.Ijbiomac.2010.07.001 |
0.342 |
|
| 2010 |
de Castro S, Maruoka H, Hong K, Kilbey SM, Costanzi S, Hechler B, Brown GG, Gachet C, Harden TK, Jacobson KA. Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. Bioconjugate Chemistry. 21: 1190-205. PMID 20565071 DOI: 10.1021/Bc900569U |
0.719 |
|
| 2010 |
Hu J, Wang Y, Zhang X, Lloyd JR, Li JH, Karpiak J, Costanzi S, Wess J. Structural basis of G protein-coupled receptor-G protein interactions. Nature Chemical Biology. 6: 541-8. PMID 20512139 DOI: 10.1038/Nchembio.385 |
0.526 |
|
| 2010 |
Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. Journal of Medicinal Chemistry. 53: 4488-501. PMID 20446735 DOI: 10.1021/Jm100287T |
0.836 |
|
| 2010 |
Vilar S, Karpiak J, Costanzi S. Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptor. Journal of Computational Chemistry. 31: 707-20. PMID 19569204 DOI: 10.1002/Jcc.21346 |
0.507 |
|
| 2010 |
Lambertucci C, Costanzi S, Vittori S, Volpini R, Cristalli G. ChemInform Abstract: Synthesis and Adenosine Receptor Affinity and Potency of 8-Alkynyl Derivatives of Adenosine Cheminform. 32: no-no. DOI: 10.1002/CHIN.200149218 |
0.544 |
|
| 2010 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Cristalli G. ChemInform Abstract: Synthetic Procedure for the Preparation of Novel Potent and Selective A3 Adenosine Receptor Radioligands Cheminform. 32: no-no. DOI: 10.1002/CHIN.200148181 |
0.432 |
|
| 2010 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Klotz K, Lorenzen A, Cristalli G. ChemInform Abstract: Introduction of Alkynyl Chains on C-8 of Adenosine Led to Very Selective Antagonists of the A3 Adenosine Receptor. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200146238 |
0.433 |
|
| 2010 |
Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E. ChemInform Abstract: Adenosine Deaminase: Functional Implications and Different Classes of Inhibitors Cheminform. 32: no-no. DOI: 10.1002/CHIN.200122256 |
0.549 |
|
| 2010 |
Vittori S, Lorenzen A, Stannek C, Costanzi S, Volpini R, IJzerman AP, Von Frijtag Drabbe Kunzel JK, Cristalli G. ChemInform Abstract: N-Cycloalkyl Derivatives of Adenosine and 1-Deazaadenosine as Agonists and Partial Agonists of the A1 Adenosine Receptor. Cheminform. 31: no-no. DOI: 10.1002/chin.200016239 |
0.473 |
|
| 2010 |
Volpini R, Camaioni E, Costanzi S, Vittori S, Klotz K, Cristalli G. ChemInform Abstract: Synthesis of Di- and Trisubstituted Adenosine Derivatives (V) and (VIII) and Their Affinities at Human Adenosine Receptor Subtypes. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200016235 |
0.731 |
|
| 2010 |
Vittori S, Camaioni E, Costanzi S, Volpini R, Cristalli G. ChemInform Abstract: Coupling of 2,6-Dichloropurine and 2,6-Dichlorodeazapurines with Ribose and Ribose Modified Sugars Cheminform. 30: no-no. DOI: 10.1002/CHIN.199941217 |
0.543 |
|
| 2010 |
Volpini R, Camaioni E, Costanzi S, Vittori S, Cristalli G. ChemInform Abstract: Synthesis of New 3′-Deoxyribonucleosides Employing the Acid-Catalyzed Fusion Method. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199916238 |
0.521 |
|
| 2009 |
Tikhonova IG, Costanzi S. Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy. Current Pharmaceutical Design. 15: 4003-16. PMID 20028318 DOI: 10.2174/138161209789824803 |
0.488 |
|
| 2009 |
Costanzi S, Siegel J, Tikhonova IG, Jacobson KA. Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors. Current Pharmaceutical Design. 15: 3994-4002. PMID 20028316 DOI: 10.2174/138161209789824795 |
0.674 |
|
| 2009 |
Pooput C, Rosemond E, Karpiak J, Deflorian F, Vilar S, Costanzi S, Wess J, Kirk KL. Structural basis of the selectivity of the β2-adrenergic receptor for fluorinated catecholamines Bioorganic and Medicinal Chemistry. 17: 7987-7992. PMID 19857969 DOI: 10.1016/J.Bmc.2009.10.015 |
0.651 |
|
| 2009 |
Fatakia SN, Costanzi S, Chow CC. Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors. Plos One. 4: e4681. PMID 19262747 DOI: 10.1371/Journal.Pone.0004681 |
0.453 |
|
| 2009 |
Sum CS, Tikhonova IG, Costanzi S, Gershengorn MC. Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. The Journal of Biological Chemistry. 284: 3529-36. PMID 19068482 DOI: 10.1074/Jbc.M806987200 |
0.57 |
|
| 2009 |
Costanzi S, Tikhonova IG, Harden TK, Jacobson KA. Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands. Journal of Computer-Aided Molecular Design. 23: 747-54. PMID 18483766 DOI: 10.1007/S10822-008-9218-3 |
0.617 |
|
| 2009 |
Fatakia SN, Costanzi S, Chow CC, Periwal V. From Abstract Graphs To (biophysical) Reality - Graphs In Mutual Information Space Help Identify Highly Correlated Positions In G Protein-coupled Receptors Biophysical Journal. 96: 650a. DOI: 10.1016/J.Bpj.2008.12.3434 |
0.327 |
|
| 2008 |
Jiang JK, Ghoreschi K, Deflorian F, Chen Z, Perreira M, Pesu M, Smith J, Nguyen DT, Liu EH, Leister W, Costanzi S, O'Shea JJ, Thomas CJ. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). Journal of Medicinal Chemistry. 51: 8012-8. PMID 19053756 DOI: 10.1021/Jm801142B |
0.311 |
|
| 2008 |
Houston D, Costanzi S, Jacobson KA, Harden TK. Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor. Combinatorial Chemistry & High Throughput Screening. 11: 410-9. PMID 18673269 DOI: 10.2174/138620708784911474 |
0.758 |
|
| 2008 |
Neumann S, Kleinau G, Costanzi S, Moore S, Jiang JK, Raaka BM, Thomas CJ, Krause G, Gershengorn MC. A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology. 149: 5945-50. PMID 18669595 DOI: 10.1210/En.2008-0836 |
0.55 |
|
| 2008 |
Tikhonova IG, Best RB, Engel S, Gershengorn MC, Hummer G, Costanzi S. Atomistic insights into rhodopsin activation from a dynamic model. Journal of the American Chemical Society. 130: 10141-9. PMID 18620390 DOI: 10.1021/Ja0765520 |
0.419 |
|
| 2008 |
Costanzi S. On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. Journal of Medicinal Chemistry. 51: 2907-14. PMID 18442228 DOI: 10.1021/Jm800044K |
0.532 |
|
| 2008 |
Costanzi S, Neumann S, Gershengorn MC. Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects. The Journal of Biological Chemistry. 283: 16269-73. PMID 18385136 DOI: 10.1074/Jbc.R800014200 |
0.396 |
|
| 2008 |
Engel S, Skoumbourdis AP, Childress J, Neumann S, Deschamps JR, Thomas CJ, Colson AO, Costanzi S, Gershengorn MC. A virtual screen for diverse ligands: Discovery of selective G protein-coupled receptor antagonists Journal of the American Chemical Society. 130: 5115-5123. PMID 18357984 DOI: 10.1021/Ja077620L |
0.576 |
|
| 2008 |
Tikhonova IG, Sum CS, Neumann S, Engel S, Raaka BM, Costanzi S, Gershengorn MC. Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening. Journal of Medicinal Chemistry. 51: 625-33. PMID 18193825 DOI: 10.1021/Jm7012425 |
0.596 |
|
| 2008 |
Deflorian F, Engel S, Colson AO, Raaka BM, Gershengorn MC, Costanzi S. Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2 Proteins: Structure, Function and Genetics. 71: 783-794. PMID 17979196 DOI: 10.1002/Prot.21763 |
0.475 |
|
| 2008 |
Hu J, Li J, Costanzi S, Zhang X, Wess J. Mapping of Contact Sites Between the M3 Muscarinic Acetylcholine Receptor and Gq by Cross‐linking Approaches The Faseb Journal. 22: 293-293. DOI: 10.1096/Fasebj.22.2_Supplement.293 |
0.423 |
|
| 2007 |
Sum CS, Tikhonova IG, Neumann S, Engel S, Raaka BM, Costanzi S, Gershengorn MC. Identification of residues important for agonist recognition and activation in GPR40. The Journal of Biological Chemistry. 282: 29248-55. PMID 17699519 DOI: 10.1074/Jbc.M705077200 |
0.531 |
|
| 2007 |
Costanzi S, Tikhonova IG, Ohno M, Roh EJ, Joshi BV, Colson AO, Houston D, Maddileti S, Harden TK, Jacobson KA. P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. Journal of Medicinal Chemistry. 50: 3229-41. PMID 17564423 DOI: 10.1021/Jm0700971 |
0.756 |
|
| 2007 |
Tikhonova IG, Sum CS, Neumann S, Thomas CJ, Raaka BM, Costanzi S, Gershengorn MC. Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition. Journal of Medicinal Chemistry. 50: 2981-9. PMID 17552505 DOI: 10.1021/Jm0614782 |
0.535 |
|
| 2007 |
Ivanov AA, Ko H, Cosyn L, Maddileti S, Besada P, Fricks I, Costanzi S, Harden TK, Calenbergh SV, Jacobson KA. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. Journal of Medicinal Chemistry. 50: 1166-76. PMID 17302398 DOI: 10.1021/Jm060903O |
0.842 |
|
| 2006 |
Jacobson KA, Costanzi S, Kim SK, Roh E, Joshi BV, Tchilibon S, Duong HT, Gao ZG. Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors. Nucleosides, Nucleotides & Nucleic Acids. 25: 1425-36. PMID 17067963 DOI: 10.1080/15257770600919027 |
0.855 |
|
| 2006 |
Ivanov AA, Costanzi S, Jacobson KA. Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling. Journal of Computer-Aided Molecular Design. 20: 417-26. PMID 17016747 DOI: 10.1007/S10822-006-9054-2 |
0.816 |
|
| 2006 |
Besada P, Shin DH, Costanzi S, Ko H, Mathé C, Gagneron J, Gosselin G, Maddileti S, Harden TK, Jacobson KA. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. Journal of Medicinal Chemistry. 49: 5532-43. PMID 16942026 DOI: 10.1021/Jm060485N |
0.852 |
|
| 2006 |
Jacobson KA, Costanzi S, Joshi BV, Besada P, Shin DH, Ko H, Ivanov AA, Mamedova L. Agonists and antagonists for P2 receptors. Novartis Foundation Symposium. 276: 58-68; discussion 68. PMID 16805423 DOI: 10.1002/9780470032244.Ch6 |
0.831 |
|
| 2006 |
Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patterns Journal of Medicinal Chemistry. 49: 3888-3896. PMID 16789744 DOI: 10.1021/Jm060247S |
0.55 |
|
| 2006 |
Hu J, Jiang J, Costanzi S, Thomas C, Yang W, Feyen JH, Jacobson KA, Spiegel AM. A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator. The Journal of Biological Chemistry. 281: 21558-65. PMID 16735501 DOI: 10.1074/Jbc.M603682200 |
0.648 |
|
| 2006 |
Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR) Journal of Biological Chemistry. 281: 9841-9844. PMID 16488885 DOI: 10.1074/Jbc.C600014200 |
0.585 |
|
| 2006 |
Jacobson KA, Costanzi S, Ivanov AA, Tchilibon S, Besada P, Gao ZG, Maddileti S, Harden TK. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochemical Pharmacology. 71: 540-9. PMID 16359641 DOI: 10.1016/J.Bcp.2005.11.010 |
0.87 |
|
| 2005 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Martini C, Trincavelli ML, Klotz KN, Cristalli G. 2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors. Purinergic Signalling. 1: 173-81. PMID 18404502 DOI: 10.1007/S11302-005-6216-Y |
0.575 |
|
| 2005 |
Costanzi S, Joshi BV, Maddileti S, Mamedova L, Gonzalez-Moa MJ, Marquez VE, Harden TK, Jacobson KA. Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference. Journal of Medicinal Chemistry. 48: 8108-11. PMID 16366591 DOI: 10.1021/Jm050911P |
0.84 |
|
| 2005 |
Costanzi S, Lambertucci C, Portino F, Volpini R, Vittori S, Cristalli G. Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents. Nucleosides, Nucleotides & Nucleic Acids. 24: 415-418. PMID 16247961 DOI: 10.1081/Ncn-200059860 |
0.366 |
|
| 2005 |
Besada P, Mamedova L, Thomas CJ, Costanzi S, Jacobson KA. Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality. Organic & Biomolecular Chemistry. 3: 2016-25. PMID 15889186 DOI: 10.1039/B416349D |
0.842 |
|
| 2005 |
Jacobson KA, Mamedova L, Joshi BV, Besada P, Costanzi S. Molecular recognition at adenine nucleotide (P2) receptors in platelets. Seminars in Thrombosis and Hemostasis. 31: 205-16. PMID 15852224 DOI: 10.1055/S-2005-869526 |
0.856 |
|
| 2005 |
Cristalli G, Podda GM, Costanzi S, Lambertucci C, Lecchi A, Vittori S, Volpini R, Zighetti ML, Cattaneo M. Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. Journal of Medicinal Chemistry. 48: 2763-6. PMID 15828813 DOI: 10.1021/Jm0493562 |
0.383 |
|
| 2004 |
Jacobson KA, Kim SK, Costanzi S, Gao ZG. Purine receptors: GPCR structure and agonist design. Molecular Interventions. 4: 337-47. PMID 15616163 DOI: 10.1124/Mi.4.6.7 |
0.8 |
|
| 2004 |
Costanzi S, Mamedova L, Gao ZG, Jacobson KA. Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. Journal of Medicinal Chemistry. 47: 5393-404. PMID 15481977 DOI: 10.1021/Jm049914C |
0.836 |
|
| 2004 |
Ohno M, Costanzi S, Kim HS, Kempeneers V, Vastmans K, Herdewijn P, Maddileti S, Gao ZG, Harden TK, Jacobson KA. Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors. Bioorganic & Medicinal Chemistry. 12: 5619-30. PMID 15465340 DOI: 10.1016/J.Bmc.2004.07.067 |
0.781 |
|
| 2004 |
Jacobson KA, Costanzi S, Ohno M, Joshi BV, Besada P, Xu B, Tchilibon S. Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Current Topics in Medicinal Chemistry. 4: 805-19. PMID 15078212 DOI: 10.2174/1568026043450961 |
0.853 |
|
| 2004 |
D'Ambrosi N, Costanzi S, Angelini DF, Volpini R, Sancesario G, Cristalli G, Volonté C. 2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines. Biochemical Pharmacology. 67: 621-30. PMID 14757162 DOI: 10.1016/J.Bcp.2003.09.015 |
0.462 |
|
| 2004 |
Volpini R, Costanzi S, Lambertucci C, Portino FR, Taffi S, Vittori S, Klotz K, Cristalli G. Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl)alkylthioadenosine derivatives Arkivoc. 2004: 301-311. DOI: 10.3998/Ark.5550190.0005.526 |
0.55 |
|
| 2004 |
Vittori S, Costanzi S, Lambertucci C, Portino FR, Taffi S, Volpini R, Klotz K, Cristalli G. A2B Adenosine Receptor Agonists: Synthesis and Biological Evaluation of 2-Phenylhydroxypropynyl Adenosine and NECA Derivatives. Cheminform. 35. DOI: 10.1081/Ncn-120028340 |
0.623 |
|
| 2004 |
Costanzi S, Vincenzetti S, Vita A, Lambertucci C, Taffi S, Volpini R, Vittori S, Cristalli G. Human Cytidine Deaminase: Understanding the Catalytic Mechanism Cheminform. 35. DOI: 10.1081/Ncn-120023029 |
0.309 |
|
| 2004 |
Lambertucci C, Volpini R, Costanzi S, Taffi S, Vittori S, Cristalli G. 2-Phenylhydroxypropynyladenosine Derivatives as High Potent Agonists at A2B Adenosine Receptor Subtype Cheminform. 35. DOI: 10.1081/Ncn-120022640 |
0.569 |
|
| 2003 |
Cristalli G, Costanzi S, Lambertucci C, Taffi S, Vittori S, Volpini R. Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity. Farmaco (Società Chimica Italiana : 1989). 58: 193-204. PMID 12620415 DOI: 10.1016/S0014-827X(03)00019-3 |
0.585 |
|
| 2003 |
Volpini R, Costanzi S, Vittori S, Cristalli G, Klotz KN. Medicinal chemistry and pharmacology of A2B adenosine receptors. Current Topics in Medicinal Chemistry. 3: 427-43. PMID 12570760 DOI: 10.2174/1568026033392264 |
0.644 |
|
| 2003 |
Costanzi S, Lambertucci C, Vittori S, Volpini R, Cristalli G. 2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior. Journal of Molecular Graphics & Modelling. 21: 253-62. PMID 12479925 DOI: 10.1016/S1093-3263(02)00161-4 |
0.596 |
|
| 2002 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Cristalli G. Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists. Current Pharmaceutical Design. 8: 2285-98. PMID 12369946 DOI: 10.2174/1381612023392856 |
0.53 |
|
| 2002 |
Salvatori D, Volpini R, Vincenzetti S, Vita A, Costanzi S, Lambertucci C, Cristalli G, Vittori S. Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1. Bioorganic & Medicinal Chemistry. 10: 2973-80. PMID 12110319 DOI: 10.1016/S0968-0896(02)00131-1 |
0.325 |
|
| 2002 |
Volpini R, Costanzi S, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. Journal of Medicinal Chemistry. 45: 3271-9. PMID 12109910 DOI: 10.1021/Jm0109762 |
0.493 |
|
| 2001 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Cristalli G. Synthetic procedure for the preparation of novel potent and selective A3 adenosine receptor radioligands. Nucleosides, Nucleotides & Nucleic Acids. 20: 775-779. PMID 11563114 DOI: 10.1081/Ncn-100002428 |
0.536 |
|
| 2001 |
Lambertucci C, Costanzi S, Vittori S, Volpini R, Cristalli G. Synthesis And Adenosine Receptor Affinity And Potency Of 8-Alkynyl Derivatives Of Adenosine Nucleosides, Nucleotides & Nucleic Acids. 20: 1153-1157. PMID 11562976 DOI: 10.1081/Ncn-100002509 |
0.591 |
|
| 2001 |
Costanzi S, Lambertucci C, Volpini R, Vittori S, Lupidi G, Cristalli G. 3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors. Nucleosides, Nucleotides & Nucleic Acids. 20: 1037-1041. PMID 11562953 DOI: 10.1081/Ncn-100002486 |
0.322 |
|
| 2001 |
Volpini R, Costanzi S, Lambertucci C, Vittori S, Klotz K-, Lorenzen A, Cristalli G. Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorganic & Medicinal Chemistry Letters. 11: 1931-1934. PMID 11459663 DOI: 10.1016/S0960-894X(01)00347-X |
0.64 |
|
| 2001 |
Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E. Adenosine deaminase: functional implications and different classes of inhibitors. Medicinal Research Reviews. 21: 105-28. PMID 11223861 DOI: 10.1002/1098-1128(200103)21:2<105::Aid-Med1002>3.0.Co;2-U |
0.587 |
|
| 2000 |
Vittori S, Lorenzen A, Stannek C, Costanzi S, Volpini R, IJzerman AP, Kunzel JK, Cristalli G. N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor. Journal of Medicinal Chemistry. 43: 250-60. PMID 10649980 DOI: 10.1021/Jm9911231 |
0.646 |
|
| 2000 |
Volpini R, Camaioni E, Costanzi S, Vittori S, Klotz KN, Cristalli G. Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes. Nucleosides & Nucleotides. 18: 2511-20. PMID 10639752 DOI: 10.1080/07328319908044623 |
0.758 |
|
| 1999 |
Vittori S, Camaioni E, Costanzi S, Volpini R, Klotz KN, Cristalli G. Synthesis and receptor affinity of polysubstituted adenosines. Nucleosides & Nucleotides. 18: 739-40. PMID 10432676 DOI: 10.1080/15257779908041560 |
0.76 |
|
| 1999 |
Barbieri D, Franceschi C, Camaioni E, Costanzi S, Vittori S, Volpini R, Cristalli G. Modulation of apoptosis in human lymphocytes by adenosine analogues. Bioorganic & Medicinal Chemistry Letters. 8: 2533-8. PMID 9873575 DOI: 10.1016/S0960-894X(98)00452-1 |
0.598 |
|
| 1999 |
Vittori S, Camaioni E, Costanzi S, Volpini R, Lupidi G, Cristalli G. Structure-Activity Relationships of Adenosine Deaminase Inhibitors Nucleosides and Nucleotides. 18: 741-742. DOI: 10.1080/15257779908041561 |
0.649 |
|
| 1999 |
Vittori S, Camaioni E, Costanzi S, Volpini R, Cristalli G. Coupling of 2,6-Dichloropurine and 2,6-Dichlorodeazapurines with Ribose and Ribose Modified Sugars Nucleosides and Nucleotides. 18: 587-590. DOI: 10.1080/15257779908041503 |
0.623 |
|
| 1999 |
Volpini R, Costanzi S, Vittori S, Cristalli G, Lupidi G. Synthesis and Adenosine Deaminase Inhibitory Activity of 3′-Deoxy-1-deazaadenosines Helvetica Chimica Acta. 82: 2112-2118. DOI: 10.1002/(Sici)1522-2675(19991215)82:12<2112::Aid-Hlca2112>3.0.Co;2-2 |
0.361 |
|
| 1998 |
Baraldi PG, Cacciari B, Pineda de Las Infantas MJ, Romagnoli R, Spalluto G, Volpini R, Costanzi S, Vittori S, Cristalli G, Melman N, Park KS, Ji XD, Jacobson KA. Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists. Journal of Medicinal Chemistry. 41: 3174-85. PMID 9703463 DOI: 10.1021/Jm980147P |
0.636 |
|
| 1998 |
Camaioni E, Costanzi S, Vittori S, Volpini R, Klotz KN, Cristalli G. New substituted 9-alkylpurines as adenosine receptor ligands. Bioorganic & Medicinal Chemistry. 6: 523-33. PMID 9629466 DOI: 10.1016/S0968-0896(98)00007-8 |
0.753 |
|
| 1998 |
Volpini R, Camaioni E, Costanzi S, Vittori S, Cristalli G. Synthesis of New 3′-Deoxyribonucleosides Employing the Acid-Catalyzed Fusion Method Helvetica Chimica Acta. 81: 2326-2331. DOI: 10.1002/(Sici)1522-2675(19981216)81:12<2326::Aid-Hlca2326>3.0.Co;2-4 |
0.583 |
|
| 1998 |
Cristalli G, Camaioni E, Costanzi S, Vittori S, Volpini R, Klotz K. Characterization of potent ligands at human recombinant adenosine receptors Drug Development Research. 45: 176-181. DOI: 10.1002/(Sici)1098-2299(199811/12)45:3/4<176::Aid-Ddr14>3.0.Co;2-G |
0.713 |
|
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