Chris Whitfield - Publications

Affiliations: 
University of Guelph (Canada), Guelph, Ontario, Canada 
Area:
Microbiology Biology

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ovchinnikova OG, Treat LP, Teelucksingh T, Clarke BR, Miner TA, Whitfield C, Walker KA, Miller VL. Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length. Mbio. e0080023. PMID 37140436 DOI: 10.1128/mbio.00800-23  0.301
2021 Sande C, Whitfield C. Capsules and Extracellular Polysaccharides in Escherichia coli and Salmonella. Ecosal Plus. 9: eESP00332020. PMID 34910576 DOI: 10.1128/ecosalplus.ESP-0033-2020  0.359
2021 Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH. The molecular basis of regulation of bacterial capsule assembly by Wzc. Nature Communications. 12: 4349. PMID 34272394 DOI: 10.1038/s41467-021-24652-1  0.309
2020 Whitfield C, Wear SS, Sande C. Assembly of Bacterial Capsular Polysaccharides and Exopolysaccharides. Annual Review of Microbiology. PMID 32680453 DOI: 10.1146/Annurev-Micro-011420-075607  0.369
2020 Clarke BR, Ovchinnikova OG, Sweeney RP, Kamski-Hennekam ER, Gitalis R, Mallette E, Kelly SD, Lowary TL, Kimber MS, Whitfield C. A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family. Nature Chemical Biology. PMID 32152541 DOI: 10.1038/S41589-020-0494-0  0.328
2019 Wear SS, Hunt BA, Clarke BR, Whitfield C. Analysis of the topology and active site residues of WbbF, a putative O-polysaccharide synthase from Serovar Borreze. Journal of Bacteriology. PMID 31792013 DOI: 10.1128/JB.00625-19  0.319
2019 Mann E, Kimber MS, Whitfield C. Bioinformatics analysis of diversity in bacterial glycan chain-termination chemistry and organization of carbohydrate binding modules linked to ABC transporters. Glycobiology. PMID 31504498 DOI: 10.1093/Glycob/Cwz066  0.38
2019 Sande C, Bouwman C, Kell E, Nickerson NN, Kapadia SB, Whitfield C. Structural and functional variation in outer membrane polysaccharide export (OPX) proteins from the two major capsule assembly pathways present in . Journal of Bacteriology. PMID 31036729 DOI: 10.1128/Jb.00213-19  0.383
2019 Williams DM, Ovchinnikova OG, Whitfield C. In Vitro Characterization of a Multidomain Glycosyltransferase Using Fluorescently Tagged Synthetic Acceptors. Methods in Molecular Biology (Clifton, N.J.). 1954: 245-253. PMID 30864137 DOI: 10.1007/978-1-4939-9154-9_19  0.336
2019 Doyle L, Ovchinnikova OG, Whitfield C. Utilization of Fluorescently Tagged Synthetic Acceptor Molecules for In Vitro Characterization of a Dual-Domain Glycosyltransferase Enzyme, KpsC, from Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 1954: 151-159. PMID 30864130 DOI: 10.1007/978-1-4939-9154-9_12  0.324
2018 Liston SD, McMahon SA, Le Bas A, Suits MDL, Naismith JH, Whitfield C. Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735649 DOI: 10.1073/Pnas.1801336115  0.766
2018 Clarke BR, Ovchinnikova OG, Kelly SD, Williamson ML, Butler JE, Liu B, Wang L, Gou X, Follador R, Lowary TL, Whitfield C. Molecular basis for the structural diversity in serogroup O2-antigen polysaccharides in. The Journal of Biological Chemistry. 293: 4666-4679. PMID 29602878 DOI: 10.1074/Jbc.Ra117.000646  0.389
2018 Bi Y, Mann E, Whitfield C, Zimmer J. Architecture of a channel-forming O-antigen polysaccharide ABC transporter. Nature. PMID 29320481 DOI: 10.1038/Nature25190  0.407
2017 Diao J, Bouwman C, Yan D, Kang J, Katakam AK, Liu P, Pantua H, Abbas AR, Nickerson NN, Austin C, Reichelt M, Sandoval W, Xu M, Whitfield C, Kapadia SB. Peptidoglycan Association of Murein Lipoprotein Is Required for KpsD-Dependent Group 2 Capsular Polysaccharide Expression and Serum Resistance in a Uropathogenic Escherichia coli Isolate. Mbio. 8. PMID 28536290 DOI: 10.1128/Mbio.00603-17  0.434
2017 Collins RF, Kargas V, Clarke BR, Siebert CA, Clare DK, Bond PJ, Whitfield C, Ford RC. Full-length, Oligomeric Structure of Wzz Determined by Cryoelectron Microscopy Reveals Insights into Membrane-Bound States. Structure (London, England : 1993). PMID 28434914 DOI: 10.1016/J.Str.2017.03.017  0.401
2017 Williams DM, Ovchinnikova OG, Koizumi A, Mainprize IL, Kimber MS, Lowary TL, Whitfield C. Single polysaccharide assembly protein that integrates polymerization, termination, and chain-length quality control. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137848 DOI: 10.1073/Pnas.1613609114  0.305
2016 Liston SD, Mann E, Whitfield C. Glycolipid substrates for ABC transporters required for the assembly of bacterial cell-envelope and cell-surface glycoconjugates. Biochimica Et Biophysica Acta. PMID 27793707 DOI: 10.1016/j.bbalip.2016.10.008  0.763
2016 Ovchinnikova OG, Doyle L, Huang BS, Kimber MS, Lowary TL, Whitfield C. Biochemical characterization of bifunctional 3-deoxy-β-D-manno-oct-2-ulosonic acid (β‑Kdo) transferase KpsC from Escherichia coli involved in capsule biosynthesis. The Journal of Biological Chemistry. PMID 27535220 DOI: 10.1074/Jbc.M116.751115  0.369
2016 Liston SD, Ovchinnikova OG, Whitfield C. Unique lipid anchor attaches Vi antigen capsule to the surface of Salmonella enterica serovar Typhi. Proceedings of the National Academy of Sciences of the United States of America. PMID 27226298 DOI: 10.1073/pnas.1524665113  0.742
2016 Filloux A, Whitfield C. Editorial: The many wonders of the bacterial cell surface. Fems Microbiology Reviews. 40: 161-3. PMID 26684539 DOI: 10.1093/Femsre/Fuv047  0.364
2015 Mann E, Ovchinnikova OG, King JD, Whitfield C. Bacteriophage-mediated glucosylation can modify lipopolysaccharide O antigens synthesized by an ABC transporter-dependent assembly mechanism. The Journal of Biological Chemistry. PMID 26330553 DOI: 10.1074/Jbc.M115.660803  0.43
2015 Hagelueken G, Clarke BR, Huang H, Tuukkanen A, Danciu I, Svergun DI, Hussain R, Liu H, Whitfield C, Naismith JH. A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide. Nature Structural & Molecular Biology. 22: 50-6. PMID 25504321 DOI: 10.1038/Nsmb.2935  0.355
2015 Liston SD, Clarke BR, Greenfield LK, Richards MR, Lowary TL, Whitfield C. Domain interactions control complex formation and polymerase specificity in the biosynthesis of the Escherichia coli O9a antigen. The Journal of Biological Chemistry. 290: 1075-85. PMID 25422321 DOI: 10.1074/Jbc.M114.622480  0.769
2014 Nickerson NN, Mainprize IL, Hampton L, Jones ML, Naismith JH, Whitfield C. Trapped translocation intermediates establish the route for export of capsular polysaccharides across Escherichia coli outer membranes. Proceedings of the National Academy of Sciences of the United States of America. 111: 8203-8. PMID 24843147 DOI: 10.1073/Pnas.1400341111  0.418
2014 King JD, Berry S, Clarke BR, Morris RJ, Whitfield C. Lipopolysaccharide O antigen size distribution is determined by a chain extension complex of variable stoichiometry in Escherichia coli O9a Proceedings of the National Academy of Sciences of the United States of America. 111: 6407-6412. PMID 24733938 DOI: 10.1073/Pnas.1400814111  0.341
2014 Whitfield C, Trent MS. Biosynthesis and export of bacterial lipopolysaccharides. Annual Review of Biochemistry. 83: 99-128. PMID 24580642 DOI: 10.1146/Annurev-Biochem-060713-035600  0.405
2013 Willis LM, Whitfield C. KpsC and KpsS are retaining 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferases involved in synthesis of bacterial capsules. Proceedings of the National Academy of Sciences of the United States of America. 110: 20753-8. PMID 24302764 DOI: 10.1073/Pnas.1312637110  0.45
2013 Mainprize IL, Bean JD, Bouwman C, Kimber MS, Whitfield C. The UDP-glucose dehydrogenase of Escherichia coli K-12 displays substrate inhibition by NAD that is relieved by nucleotide triphosphates. The Journal of Biological Chemistry. 288: 23064-74. PMID 23792965 DOI: 10.1074/Jbc.M113.486613  0.441
2013 Willis LM, Whitfield C. Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways. Carbohydrate Research. 378: 35-44. PMID 23746650 DOI: 10.1016/j.carres.2013.05.007  0.359
2013 Bushell SR, Mainprize IL, Wear MA, Lou H, Whitfield C, Naismith JH. Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli. Structure (London, England : 1993). 21: 844-53. PMID 23623732 DOI: 10.1016/J.Str.2013.03.010  0.45
2013 Willis LM, Stupak J, Richards MR, Lowary TL, Li J, Whitfield C. Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens. Proceedings of the National Academy of Sciences of the United States of America. 110: 7868-73. PMID 23610430 DOI: 10.1073/Pnas.1222317110  0.482
2012 Greenfield LK, Richards MR, Vinogradov E, Wakarchuk WW, Lowary TL, Whitfield C. Domain organization of the polymerizing mannosyltransferases involved in synthesis of the Escherichia coli O8 and O9a lipopolysaccharide O-antigens. The Journal of Biological Chemistry. 287: 38135-49. PMID 22989876 DOI: 10.1074/Jbc.M112.412577  0.387
2012 Hagelueken G, Huang H, Clarke BR, Lebl T, Whitfield C, Naismith JH. Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a. Molecular Microbiology. 86: 730-42. PMID 22970759 DOI: 10.1111/Mmi.12014  0.397
2012 Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C. Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases. The Journal of Biological Chemistry. 287: 35078-91. PMID 22875852 DOI: 10.1074/Jbc.M112.401000  0.409
2012 Greenfield LK, Whitfield C. Synthesis of lipopolysaccharide O-antigens by ABC transporter-dependent pathways. Carbohydrate Research. 356: 12-24. PMID 22475157 DOI: 10.1016/J.Carres.2012.02.027  0.388
2012 Kubler-Kielb J, Whitfield C, Katzenellenbogen E, Vinogradov E. Identification of the methyl phosphate substituent at the non-reducing terminal mannose residue of the O-specific polysaccharides of Klebsiella pneumoniae O3, Hafnia alvei PCM 1223 and Escherichia coli O9/O9a LPS. Carbohydrate Research. 347: 186-8. PMID 22169179 DOI: 10.1016/J.Carres.2011.11.019  0.374
2011 Clarke BR, Richards MR, Greenfield LK, Hou D, Lowary TL, Whitfield C. In vitro reconstruction of the chain termination reaction in biosynthesis of the Escherichia coli O9a O-polysaccharide: the chain-length regulator, WbdD, catalyzes the addition of methyl phosphate to the non-reducing terminus of the growing glycan. The Journal of Biological Chemistry. 286: 41391-401. PMID 21990359 DOI: 10.1074/Jbc.M111.295857  0.381
2011 Leipold MD, Ornatsky O, Baranov V, Whitfield C, Nitz M. Development of mass cytometry methods for bacterial discrimination. Analytical Biochemistry. 419: 1-8. PMID 21871432 DOI: 10.1016/J.Ab.2011.07.035  0.361
2011 Larue K, Ford RC, Willis LM, Whitfield C. Functional and structural characterization of polysaccharide co-polymerase proteins required for polymer export in ATP-binding cassette transporter-dependent capsule biosynthesis pathways. The Journal of Biological Chemistry. 286: 16658-68. PMID 21454677 DOI: 10.1074/Jbc.M111.228221  0.441
2010 Cuthbertson L, Kos V, Whitfield C. ABC transporters involved in export of cell surface glycoconjugates. Microbiology and Molecular Biology Reviews : Mmbr. 74: 341-62. PMID 20805402 DOI: 10.1128/Mmbr.00009-10  0.401
2010 Tran AX, Dong C, Whitfield C. Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. The Journal of Biological Chemistry. 285: 33529-39. PMID 20720015 DOI: 10.1074/Jbc.M110.144709  0.395
2010 Whitfield C. Glycan chain-length control. Nature Chemical Biology. 6: 403-4. PMID 20479750 DOI: 10.1038/Nchembio.376  0.337
2010 Kos V, Whitfield C. A membrane-located glycosyltransferase complex required for biosynthesis of the D-galactan I lipopolysaccharide O antigen in Klebsiella pneumoniae. The Journal of Biological Chemistry. 285: 19668-87. PMID 20410291 DOI: 10.1074/Jbc.M110.122598  0.38
2010 Whitfield C, Mainprize IL. TPR motifs: hallmarks of a new polysaccharide export scaffold. Structure (London, England : 1993). 18: 151-3. PMID 20159460 DOI: 10.1016/J.Str.2010.01.006  0.344
2009 Whitfield C. Structure and Assembly of Escherichia coli Capsules. Ecosal Plus. 3. PMID 26443756 DOI: 10.1128/ecosalplus.4.7.3  0.382
2009 Clarke BR, Greenfield LK, Bouwman C, Whitfield C. Coordination of polymerization, chain termination, and export in assembly of the Escherichia coli lipopolysaccharide O9a antigen in an ATP-binding cassette transporter-dependent pathway. The Journal of Biological Chemistry. 284: 30662-72. PMID 19734145 DOI: 10.1074/Jbc.M109.052878  0.431
2009 Huang H, Hagelueken G, Whitfield C, Naismith JH. Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 770-2. PMID 19652335 DOI: 10.1107/S1744309109023914  0.366
2009 Hagelueken G, Huang H, Mainprize IL, Whitfield C, Naismith JH. Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly. Journal of Molecular Biology. 392: 678-88. PMID 19616007 DOI: 10.1016/J.Jmb.2009.07.026  0.44
2009 Morley TJ, Willis LM, Whitfield C, Wakarchuk WW, Withers SG. A new sialidase mechanism: bacteriophage K1F endo-sialidase is an inverting glycosidase. The Journal of Biological Chemistry. 284: 17404-10. PMID 19411257 DOI: 10.1074/Jbc.M109.003970  0.371
2009 Hagelueken G, Ingledew WJ, Huang H, Petrovic-Stojanovska B, Whitfield C, ElMkami H, Schiemann O, Naismith JH. PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli. Angewandte Chemie (International Ed. in English). 48: 2904-6. PMID 19294709 DOI: 10.1002/Anie.200805758  0.349
2009 Ford RC, Brunkan-LaMontagne AL, Collins RF, Clarke BR, Harris R, Naismith JH, Whitfield C. Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis. Journal of Structural Biology. 166: 172-82. PMID 19236919 DOI: 10.1016/J.Jsb.2009.02.005  0.424
2009 Larue K, Kimber MS, Ford R, Whitfield C. Biochemical and structural analysis of bacterial O-antigen chain length regulator proteins reveals a conserved quaternary structure. The Journal of Biological Chemistry. 284: 7395-403. PMID 19129185 DOI: 10.1074/Jbc.M809068200  0.425
2009 Kos V, Cuthbertson L, Whitfield C. The Klebsiella pneumoniae O2a antigen defines a second mechanism for O antigen ATP-binding cassette transporters. The Journal of Biological Chemistry. 284: 2947-56. PMID 19036729 DOI: 10.1074/Jbc.M807213200  0.363
2008 Whitfield C, Naismith JH. Periplasmic export machines for outer membrane assembly. Current Opinion in Structural Biology. 18: 466-74. PMID 18495473 DOI: 10.1016/J.Sbi.2008.04.001  0.351
2008 Tran AX, Trent MS, Whitfield C. The LptA protein of Escherichia coli is a periplasmic lipid A-binding protein involved in the lipopolysaccharide export pathway. The Journal of Biological Chemistry. 283: 20342-9. PMID 18480051 DOI: 10.1074/Jbc.M802503200  0.394
2008 Whitfield C, Larue K. Stop and go: regulation of chain length in the biosynthesis of bacterial polysaccharides. Nature Structural & Molecular Biology. 15: 121-3. PMID 18250628 DOI: 10.1038/Nsmb0208-121  0.325
2007 Cuthbertson L, Kimber MS, Whitfield C. Substrate binding by a bacterial ABC transporter involved in polysaccharide export. Proceedings of the National Academy of Sciences of the United States of America. 104: 19529-34. PMID 18032609 DOI: 10.1073/Pnas.0705709104  0.38
2007 Leipold MD, Vinogradov E, Whitfield C. Glycosyltransferases involved in biosynthesis of the outer core region of Escherichia coli lipopolysaccharides exhibit broader substrate specificities than is predicted from lipopolysaccharide structures. The Journal of Biological Chemistry. 282: 26786-92. PMID 17631498 DOI: 10.1074/Jbc.M704131200  0.385
2007 Collins RF, Beis K, Dong C, Botting CH, McDonnell C, Ford RC, Clarke BR, Whitfield C, Naismith JH. The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 104: 2390-5. PMID 17283336 DOI: 10.1073/Pnas.0607763104  0.417
2007 Steiner K, Novotny R, Patel K, Vinogradov E, Whitfield C, Valvano MA, Messner P, Schäffer C. Functional characterization of the initiation enzyme of S-layer glycoprotein glycan biosynthesis in Geobacillus stearothermophilus NRS 2004/3a. Journal of Bacteriology. 189: 2590-8. PMID 17237178 DOI: 10.1128/Jb.01592-06  0.335
2007 Leipold MD, Kaniuk NA, Whitfield C. The C-terminal Domain of the Escherichia coli WaaJ glycosyltransferase is important for catalytic activity and membrane association. The Journal of Biological Chemistry. 282: 1257-64. PMID 17090541 DOI: 10.1074/Jbc.M608164200  0.39
2007 Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH. RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. Journal of Molecular Biology. 365: 146-59. PMID 17046787 DOI: 10.1016/J.Jmb.2006.09.063  0.34
2006 Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL, Clarke BR, Whitfield C, Naismith JH. Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein. Nature. 444: 226-9. PMID 17086202 DOI: 10.1038/Nature05267  0.44
2006 Whitfield C. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Annual Review of Biochemistry. 75: 39-68. PMID 16756484 DOI: 10.1146/Annurev.Biochem.75.103004.142545  0.443
2006 Wacker M, Feldman MF, Callewaert N, Kowarik M, Clarke BR, Pohl NL, Hernandez M, Vines ED, Valvano MA, Whitfield C, Aebi M. Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems. Proceedings of the National Academy of Sciences of the United States of America. 103: 7088-93. PMID 16641107 DOI: 10.1073/Pnas.0509207103  0.369
2006 Beis K, Whitfield C, Booth I, Naismith JH. Two-step purification of outer membrane proteins. International Journal of Biological Macromolecules. 39: 10-4. PMID 16423387 DOI: 10.1016/J.Ijbiomac.2005.12.008  0.301
2006 Collins RF, Beis K, Clarke BR, Ford RC, Hulley M, Naismith JH, Whitfield C. Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. The Journal of Biological Chemistry. 281: 2144-50. PMID 16172129 DOI: 10.1074/Jbc.M508078200  0.445
2005 Reid AN, Whitfield C. functional analysis of conserved gene products involved in assembly of Escherichia coli capsules and exopolysaccharides: evidence for molecular recognition between Wza and Wzc for colanic acid biosynthesis. Journal of Bacteriology. 187: 5470-81. PMID 16030241 DOI: 10.1128/Jb.187.15.5470-5481.2005  0.445
2005 Cuthbertson L, Powers J, Whitfield C. The C-terminal domain of the nucleotide-binding domain protein Wzt determines substrate specificity in the ATP-binding cassette transporter for the lipopolysaccharide O-antigens in Escherichia coli serotypes O8 and O9a. The Journal of Biological Chemistry. 280: 30310-9. PMID 15980069 DOI: 10.1074/Jbc.M504371200  0.428
2005 Frirdich E, Whitfield C. Characterization of Gla(KP), a UDP-galacturonic acid C4-epimerase from Klebsiella pneumoniae with extended substrate specificity. Journal of Bacteriology. 187: 4104-15. PMID 15937173 DOI: 10.1128/Jb.187.12.4104-4115.2005  0.404
2005 Frirdich E, Bouwman C, Vinogradov E, Whitfield C. The role of galacturonic acid in outer membrane stability in Klebsiella pneumoniae. The Journal of Biological Chemistry. 280: 27604-12. PMID 15929980 DOI: 10.1074/jbc.M504987200  0.305
2005 Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH. Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. Journal of Molecular Biology. 348: 971-82. PMID 15843027 DOI: 10.1016/J.Jmb.2005.02.057  0.342
2005 Frirdich E, Whitfield C. Review: Lipopolysaccharide inner core oligosaccharide structure and outer membrane stability in human pathogens belonging to the Enterobacteriaceae: Journal of Endotoxin Research. 11: 133-144. DOI: 10.1177/09680519050110030201  0.397
2004 Kaniuk NA, Vinogradov E, Whitfield C. Investigation of the structural requirements in the lipopolysaccharide core acceptor for ligation of O antigens in the genus Salmonella: WaaL "ligase" is not the sole determinant of acceptor specificity. The Journal of Biological Chemistry. 279: 36470-80. PMID 15215252 DOI: 10.1074/Jbc.M401366200  0.448
2004 Clarke BR, Cuthbertson L, Whitfield C. Nonreducing terminal modifications determine the chain length of polymannose O antigens of Escherichia coli and couple chain termination to polymer export via an ATP-binding cassette transporter. The Journal of Biological Chemistry. 279: 35709-18. PMID 15184370 DOI: 10.1074/Jbc.M404738200  0.404
2004 Kaniuk NA, Vinogradov E, Li J, Monteiro MA, Whitfield C. Chromosomal and plasmid-encoded enzymes are required for assembly of the R3-type core oligosaccharide in the lipopolysaccharide of Escherichia coli O157:H7. The Journal of Biological Chemistry. 279: 31237-50. PMID 15155763 DOI: 10.1074/Jbc.M401879200  0.413
2004 Frirdich E, Vinogradov E, Whitfield C. Biosynthesis of a novel 3-deoxy-D-manno-oct-2-ulosonic acid-containing outer core oligosaccharide in the lipopolysaccharide of Klebsiella pneumoniae. The Journal of Biological Chemistry. 279: 27928-40. PMID 15090547 DOI: 10.1074/jbc.M402549200  0.313
2004 Beis K, Nesper J, Whitfield C, Naismith JH. Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30. Acta Crystallographica. Section D, Biological Crystallography. 60: 558-60. PMID 14993692 DOI: 10.1107/S0907444903029494  0.39
2004 Shankar-Sinha S, Valencia GA, Janes BK, Rosenberg JK, Whitfield C, Bender RA, Standiford TJ, Younger JG. The Klebsiella pneumoniae O antigen contributes to bacteremia and lethality during murine pneumonia. Infection and Immunity. 72: 1423-30. PMID 14977947 DOI: 10.1128/Iai.72.3.1423-1430.2004  0.393
2003 Whitfield C, Paiment A. Biosynthesis and assembly of Group 1 capsular polysaccharides in Escherichia coli and related extracellular polysaccharides in other bacteria. Carbohydrate Research. 338: 2491-502. PMID 14670711 DOI: 10.1016/J.Carres.2003.08.010  0.41
2003 Nesper J, Hill CM, Paiment A, Harauz G, Beis K, Naismith JH, Whitfield C. Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. The Journal of Biological Chemistry. 278: 49763-72. PMID 14522970 DOI: 10.1074/Jbc.M308775200  0.461
2003 Rahn A, Beis K, Naismith JH, Whitfield C. A novel outer membrane protein, Wzi, is involved in surface assembly of the Escherichia coli K30 group 1 capsule. Journal of Bacteriology. 185: 5882-90. PMID 13129961 DOI: 10.1128/Jb.185.19.5882-5890.2003  0.799
2003 Whitfield C, Kaniuk N, Frirdich E. Molecular insights into the assembly and diversity of the outer core oligosaccharide in lipopolysaccharides from Escherichia coli and Salmonella. Journal of Endotoxin Research. 9: 244-9. PMID 12935355 DOI: 10.1177/09680519030090040501  0.425
2003 Dong C, Beis K, Giraud MF, Blankenfeldt W, Allard S, Major LL, Kerr ID, Whitfield C, Naismith JH. A structural perspective on the enzymes that convert dTDP-D-glucose into dTDP-L-rhamnose Biochemical Society Transactions. 31: 532-536. PMID 12773151 DOI: 10.1042/Bst0310532  0.337
2003 Frirdich E, Lindner B, Holst O, Whitfield C. Overexpression of the waaZ gene leads to modification of the structure of the inner core region of Escherichia coli lipopolysaccharide, truncation of the outer core, and reduction of the amount of O polysaccharide on the cell surface. Journal of Bacteriology. 185: 1659-71. PMID 12591884 DOI: 10.1128/Jb.185.5.1659-1671.2003  0.481
2003 Rahn A, Whitfield C. Transcriptional organization and regulation of the Escherichia coli K30 group 1 capsule biosynthesis (cps) gene cluster. Molecular Microbiology. 47: 1045-60. PMID 12581358 DOI: 10.1046/J.1365-2958.2003.03354.X  0.777
2002 Kaniuk NA, Monteiro MA, Parker CT, Whitfield C. Molecular diversity of the genetic loci responsible for lipopolysaccharide core oligosaccharide assembly within the genus Salmonella. Molecular Microbiology. 46: 1305-18. PMID 12453217 DOI: 10.1046/J.1365-2958.2002.03243.X  0.409
2002 Paiment A, Hocking J, Whitfield C. Impact of phosphorylation of specific residues in the tyrosine autokinase, Wzc, on its activity in assembly of group 1 capsules in Escherichia coli. Journal of Bacteriology. 184: 6437-47. PMID 12426330 DOI: 10.1128/Jb.184.23.6437-6447.2002  0.395
2002 Schäffer C, Wugeditsch T, Messner P, Whitfield C. Functional expression of enterobacterial O-polysaccharide biosynthesis enzymes in Bacillus subtilis. Applied and Environmental Microbiology. 68: 4722-30. PMID 12324313 DOI: 10.1128/Aem.68.10.4722-4730.2002  0.418
2002 Blankenfeldt W, Kerr ID, Giraud MF, McMiken HJ, Leonard G, Whitfield C, Messner P, Graninger M, Naismith JH. Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure (London, England : 1993). 10: 773-86. PMID 12057193 DOI: 10.1016/S0969-2126(02)00770-0  0.303
2002 Hill C, Nesper J, Whitfield C, Harauz G. Electron Crystallography of the E. coli Outer Membrane Protein WzaK30 Microscopy and Microanalysis. 8: 836-837. DOI: 10.1017/S1431927602102534  0.33
2001 Yethon JA, Whitfield C. Lipopolysaccharide as a target for the development of novel therapeutics in gram-negative bacteria. Current Drug Targets. Infectious Disorders. 1: 91-106. PMID 12455407  0.733
2001 Sanders DAR, Staines AG, McMahon SA, McNeil MR, Whitfield C, Naismith JH. UDP-galactopyranose mutase has a novel structure and mechanism Nature Structural Biology. 8: 858-863. PMID 11573090 DOI: 10.1038/Nsb1001-858  0.341
2001 Guan S, Clarke AJ, Whitfield C. Functional analysis of the galactosyltransferases required for biosynthesis of D-galactan I, a component of the lipopolysaccharide O1 antigen of Klebsiella pneumoniae. Journal of Bacteriology. 183: 3318-27. PMID 11344139 DOI: 10.1128/Jb.183.11.3318-3327.2001  0.417
2001 Allard STM, Giraud MF, Whitfield C, Graninger M, Messner P, Naismith JH. The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-L-rhamnose pathway Journal of Molecular Biology. 307: 283-295. PMID 11243820 DOI: 10.1006/Jmbi.2000.4470  0.344
2001 Keenleyside WJ, Clarke AJ, Whitfield C. Identification of residues involved in catalytic activity of the inverting glycosyl transferase WbbE from Salmonella enterica serovar borreze Journal of Bacteriology. 183: 77-85. PMID 11114903 DOI: 10.1128/Jb.183.1.77-85.2001  0.368
2001 Yethon JA, Whitfield C. Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability. The Journal of Biological Chemistry. 276: 5498-504. PMID 11069912 DOI: 10.1074/Jbc.M008255200  0.779
2000 Wugeditsch T, Paiment A, Hocking J, Drummelsmith J, Forrester C, Whitfield C. Phosphorylation of Wzc, a tyrosine autokinase, is essential for assembly of group 1 capsular polysaccharides in Escherichia coli. The Journal of Biological Chemistry. 276: 2361-71. PMID 11053445 DOI: 10.1074/Jbc.M009092200  0.792
2000 Yethon JA, Vinogradov E, Perry MB, Whitfield C. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Journal of Bacteriology. 182: 5620-3. PMID 10986272 DOI: 10.1128/Jb.182.19.5620-5623.2000  0.756
2000 Yethon JA, Gunn JS, Ernst RK, Miller SI, Laroche L, Malo D, Whitfield C. Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence In vivo. Infection and Immunity. 68: 4485-91. PMID 10899846 DOI: 10.1128/Iai.68.8.4485-4491.2000  0.783
2000 Amor K, Heinrichs DE, Frirdich E, Ziebell K, Johnson RP, Whitfield C. Distribution of core oligosaccharide types in lipopolysaccharides from Escherichia coli Infection and Immunity. 68: 1116-1124. PMID 10678915 DOI: 10.1128/Iai.68.3.1116-1124.2000  0.372
2000 Drummelsmith J, Whitfield C. Translocation of group 1 capsular polysaccharide to the surface of Escherichia coli requires a multimeric complex in the outer membrane Embo Journal. 19: 57-66. PMID 10619844 DOI: 10.1093/Emboj/19.1.57  0.782
1999 Giraud MF, McMiken HJ, Leonard GA, Messner P, Whitfield C, Naismith JH. Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium. Acta Crystallographica. Section D, Biological Crystallography. 55: 2043-6. PMID 10666586 DOI: 10.1107/S0907444999012251  0.323
1999 Graninger M, Nidetzky B, Heinrichs DE, Whitfield C, Messner P. Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4- dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar typhimurium LT2 Journal of Biological Chemistry. 274: 25069-25077. PMID 10455186 DOI: 10.1074/Jbc.274.35.25069  0.335
1999 Drummelsmith J, Whitfield C. Gene products required for surface expression of the capsular form of the group 1 K antigen in Escherichia coli (O9a:K30) Molecular Microbiology. 31: 1321-1332. PMID 10200954 DOI: 10.1046/J.1365-2958.1999.01277.X  0.795
1999 Whitfield C, Roberts IS. Structure, assembly and regulation of expression of capsules in Escherichia coli Molecular Microbiology. 31: 1307-1319. PMID 10200953 DOI: 10.1046/J.1365-2958.1999.01276.X  0.508
1999 Giraud MF, Gordon FM, Whitfield C, Messner P, McMahon SA, Naismith JH. Purification, crystallization and preliminary structural studies of dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC), the third enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium Acta Crystallographica Section D: Biological Crystallography. 55: 706-708. PMID 10089454 DOI: 10.1107/S0907444998015042  0.31
1999 Amor PA, Yethon JA, Monteiro MA, Whitfield C. Assembly of the K40 antigen in Escherichia coli: identification of a novel enzyme responsible for addition of L-serine residues to the glycan backbone and its requirement for K40 polymerization. Journal of Bacteriology. 181: 772-80. PMID 9922239 DOI: 10.1128/Jb.181.3.772-780.1999  0.786
1999 Whitfield C, Heinrichs DE, Yethon JA, Amor KL, Monteiro MA, Perry MB. Assembly of the R1-type core oligosaccharide of Escherichia coli lipopolysaccharide Journal of Endotoxin Research. 5: 151-156. DOI: 10.1177/09680519990050030901  0.773
1999 Rahn A, Drummelsmith J, Whitfield C. Conserved Organization in the cps Gene Clusters for Expression of Escherichia coli Group 1 K Antigens: Relationship to the Colanic Acid Biosynthesis Locus and the cps Genes from Klebsiella pneumoniae Journal of Bacteriology. 181: 2307-2313. DOI: 10.1128/Jb.181.7.2307-2313.1999  0.757
1998 Heinrichs DE, Yethon JA, Amor PA, Whitfield C. The assembly system for the outer core portion of R1- and R4-type lipopolysaccharides of Escherichia coli. The R1 core-specific beta-glucosyltransferase provides a novel attachment site for O-polysaccharides. The Journal of Biological Chemistry. 273: 29497-505. PMID 9792656 DOI: 10.1074/Jbc.273.45.29497  0.742
1998 Heinrichs DE, Yethon JA, Whitfield C. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Molecular Microbiology. 30: 221-32. PMID 9791168 DOI: 10.1046/J.1365-2958.1998.01063.X  0.8
1998 Yethon JA, Heinrichs DE, Monteiro MA, Perry MB, Whitfield C. Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane. The Journal of Biological Chemistry. 273: 26310-6. PMID 9756860 DOI: 10.1074/Jbc.273.41.26310  0.76
1998 Heinrichs DE, Monteiro MA, Perry MB, Whitfield C. The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of the R2 WaaK and WaaL homologs Journal of Biological Chemistry. 273: 8849-8859. PMID 9535865 DOI: 10.1074/jbc.273.15.8849  0.361
1998 Perry MB, Whitfield C. 6.8 Structural Analysis of Cell Surface Polysaccharides from Gram-Negative Bacteria Methods in Microbiology. 27: 259-275. DOI: 10.1016/S0580-9517(08)70289-7  0.355
1998 Whitfield C, Perry MB. 6.7 Isolation and Purification of Cell Surface Polysaccharides from Gram-Negative Bacteria Methods in Microbiology. 27: 249-258. DOI: 10.1016/S0580-9517(08)70288-5  0.395
1997 Amor PA, Whitfield C. Molecular and functional analysis of genes required for expression of group IB K antigens in Escherichia coli: Characterization of the his-region containing gene clusters for multiple cell-surface polysaccharides Molecular Microbiology. 26: 145-161. PMID 9383197 DOI: 10.1046/J.1365-2958.1997.5631930.X  0.48
1997 Whitfield C, Amor PA, Köplin R. Modulation of the surface architecture of gram-negative bacteria by the action of surface polymer:lipid A-core ligase and by determinants of polymer chain length. Molecular Microbiology. 23: 629-38. PMID 9157235 DOI: 10.1046/J.1365-2958.1997.2571614.X  0.358
1997 Drummelsmith J, Amor PA, Whitfield C. Polymorphism, duplication, and IS1-mediated rearrangement in the chromosomal his-rfb-gnd region of Escherichia coli strains with group IA and capsular K antigens. Journal of Bacteriology. 179: 3232-8. PMID 9150218 DOI: 10.1128/Jb.179.10.3232-3238.1997  0.792
1997 Köplin R, Brisson JR, Whitfield C. UDP-galactofuranose precursor required for formation of the lipopolysaccharide O antigen of Klebsiella pneumoniae serotype O1 is synthesized by the product of the rfbDKPO1 gene. The Journal of Biological Chemistry. 272: 4121-8. PMID 9020123 DOI: 10.1074/Jbc.272.7.4121  0.411
1996 Keenleyside WJ, Whitfield C. A novel pathway for O-polysaccharide biosynthesis in Salmonella enterica serovar Borreze Journal of Biological Chemistry. 271: 28581-28592. PMID 8910488 DOI: 10.1074/Jbc.271.45.28581  0.389
1996 Kelly RF, Whitfield C. Clonally diverse rfb gene clusters are involved in expression of a family of related D-galactan O antigens in Klebsiella species Journal of Bacteriology. 178: 5205-5214. PMID 8752339 DOI: 10.1128/Jb.178.17.5205-5214.1996  0.403
1996 Severn WB, Kelly RF, Richards JC, Whitfield C. Structure of the core oligosaccharide in the serotype O8 lipopolysaccharide from Klebsiella pneumoniae Journal of Bacteriology. 178: 1731-1741. PMID 8626303 DOI: 10.1128/Jb.178.6.1731-1741.1996  0.429
1996 Dodgson C, Amor P, Whitfield C. Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens. Journal of Bacteriology. 178: 1895-902. PMID 8606162 DOI: 10.1128/Jb.178.7.1895-1902.1996  0.452
1995 Clarke BR, Bronner D, Keenleyside WJ, Severn WB, Richards JC, Whitfield C. Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1. Journal of Bacteriology. 177: 5411-8. PMID 7559323 DOI: 10.1128/Jb.177.19.5411-5418.1995  0.406
1995 Keenleyside WJ, Whitfield C. Lateral transfer of rfb genes: A mobilizable ColE1-type plasmid carries the rfb(O:54) (O:54 antigen biosynthesis) gene cluster from Salmonella enterica serovar borreze Journal of Bacteriology. 177: 5247-5253. PMID 7545154 DOI: 10.1128/Jb.177.18.5247-5253.1995  0.409
1995 Bronner D, Clarke BR, Whitfield C. Identification of an ATP-binding cassette transport system required for translocation of lipopolysaccharide O-antigen side-chains across the cytoplasmic membrane of Klebsiella pneumoniae serotype O1. Molecular Microbiology. 14: 505-19. PMID 7533882 DOI: 10.1111/J.1365-2958.1994.Tb02185.X  0.457
1995 Szabo M, Bronner D, Whitfield C. Relationships between rfb gene clusters required for biosynthesis of identical D-galactose-containing O antigens in Klebsiella pneumoniae serotype O1 and Serratia marcescens serotype O16 Journal of Bacteriology. 177: 1544-1553. PMID 7533758 DOI: 10.1128/Jb.177.6.1544-1553.1995  0.406
1994 MacLachlan PR, Keenleyside WJ, Dodgson C, Whitfield C. Formation of the K30 (group I) capsule in Escherichia coli O9:K30 does not require attachment to lipopolysaccharide lipid A-core. Journal of Bacteriology. 175: 7515-22. PMID 8244920 DOI: 10.1128/Jb.175.23.7515-7522.1993  0.44
1994 Jayaratne P, Bronner D, MacLachlan PR, Dodgson C, Kido N, Whitfield C. Cloning and analysis of duplicated rfbM and rfbK genes involved in the formation of GDP-mannose in Escherichia coli O9:K30 and participation of rfb genes in the synthesis of the group I K30 capsular polysaccharide. Journal of Bacteriology. 176: 3126-39. PMID 7515042 DOI: 10.1128/Jb.176.11.3126-3139.1994  0.494
1994 Keenleyside WJ, Perry M, Maclean L, Poppe C, Whitfield C. A plasmid-encoded rfbO:54 gene cluster is required for biosynthesis of the O:54 antigen in Salmonella enterica serovar Borreze. Molecular Microbiology. 11: 437-48. PMID 7512186 DOI: 10.1111/J.1365-2958.1994.Tb00325.X  0.413
1993 Keenleyside WJ, Bronner D, Jann K, Jann B, Whitfield C. Coexpression of colanic acid and serotype-specific capsular polysaccharides in Escherichia coli strains with group II K antigens. Journal of Bacteriology. 175: 6725-30. PMID 8407850 DOI: 10.1128/Jb.175.20.6725-6730.1993  0.412
1993 Jayaratne P, Keenleyside WJ, MacLachlan PR, Dodgson C, Whitfield C. Characterization of rcsB and rcsC from Escherichia coli O9:K30:H12 and examination of the role of the rcs regulatory system in expression of group I capsular polysaccharides. Journal of Bacteriology. 175: 5384-94. PMID 8366025 DOI: 10.1128/Jb.175.17.5384-5394.1993  0.459
1993 MacLean LL, Whitfield C, Perry MB. Characterization of the polysaccharide antigen of Klebsiella pneumoniae O:9 lipopolysaccharide Carbohydrate Research. 239: 325-328. PMID 7681358 DOI: 10.1016/0008-6215(93)84231-T  0.333
1993 Kelly RF, Severn WB, Richards JC, Perry MB, MacLean LL, Tomás JM, Merino S, Whitfield C. Structural variation in the O-specific polysaccharides of Klebsiella pneumoniae serotype O1 and O8 lipopolysaccharide: Evidence for clonal diversity in rfb genes Molecular Microbiology. 10: 615-625. PMID 7526122 DOI: 10.1111/J.1365-2958.1993.Tb00933.X  0.39
1992 Clarke AJ, Sarabia V, Keenleyside W, MacLachlan PR, Whitfield C. The compositional analysis of bacterial extracellular polysaccharides by high-performance anion-exchange chromatography. Analytical Biochemistry. 199: 68-74. PMID 1807163 DOI: 10.1016/0003-2697(91)90270-4  0.331
1992 Keenleyside WJ, Jayaratne P, MacLachlan PR, Whitfield C. The rcsA gene of Escherichia coli O9:K30:H12 is involved in the expression of the serotype-specific group I K (capsular) antigen. Journal of Bacteriology. 174: 8-16. PMID 1729226 DOI: 10.1128/Jb.174.1.8-16.1992  0.444
1992 Whitfield C, Perry MB, MacLean LL, Yu SH. Structural analysis of the O-antigen side chain polysaccharides in the lipopolysaccharides of Klebsiella serotypes O2(2a), O2(2a,2b), and O2(2a,2c). Journal of Bacteriology. 174: 4913-9. PMID 1378428 DOI: 10.1128/Jb.174.15.4913-4919.1992  0.338
1992 Clarke BR, Whitfield C. Molecular cloning of the rfb region of Klebsiella pneumoniae serotype O1:K20: The rfb gene cluster is responsible for synthesis of the D-galactan I O polysaccharide Journal of Bacteriology. 174: 4614-4621. PMID 1378055 DOI: 10.1128/Jb.174.14.4614-4621.1992  0.415
1991 McCallum KL, Whitfield C. The rcsA gene of Klebsiella pneumoniae O1:K20 is involved in expression of the serotype-specific K (capsular) antigen Infection and Immunity. 59: 494-502. PMID 1987069  0.312
1991 Whitfield C, Richards JC, Perry MB, Clarke BR, MacLean LL. Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1. Journal of Bacteriology. 173: 1420-31. PMID 1704883 DOI: 10.1128/Jb.173.4.1420-1431.1991  0.376
1989 Whitfield C, Schoenhals G, Graham L. Mutants of Escherichia coli O9:K30 with altered synthesis and expression of the capsular K30 antigen Journal of General Microbiology. 135: 2589-2599. PMID 2698913  0.335
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