| Year |
Citation |
Score |
| 2023 |
Orris B, Sung MW, Bhat S, Xu Y, Huynh KW, Han S, Johnson DC, Bosbach B, Shields DJ, Stivers JT. Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Research. PMID 37930833 DOI: 10.1093/nar/gkad971 |
0.483 |
|
| 2023 |
Orris B, Sung MW, Bhat S, Xu Y, Huynh KW, Han S, Johnson DC, Bosbach B, Shields DJ, Stivers JT. Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies. Biorxiv : the Preprint Server For Biology. PMID 37398126 DOI: 10.1101/2023.06.15.544806 |
0.492 |
|
| 2023 |
Egleston M, Dong L, Howlader AH, Bhat S, Orris B, Bianchet MA, Greenberg MM, Stivers JT. Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Acs Chemical Biology. PMID 37233733 DOI: 10.1021/acschembio.3c00118 |
0.323 |
|
| 2022 |
Orris B, Huynh KW, Ammirati M, Han S, Bolaños B, Carmody J, Petroski MD, Bosbach B, Shields DJ, Stivers JT. Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Research. PMID 35801923 DOI: 10.1093/nar/gkac573 |
0.347 |
|
| 2021 |
Christenson ES, Gizzi A, Cui J, Egleston M, Seamon KJ, DePasquale M, Orris B, Park BH, Stivers JT. . Molecular Pharmacology. PMID 33795350 DOI: 10.1124/molpharm.120.000191 |
0.5 |
|
| 2020 |
Meshesha M, Esadze A, Cui J, Churgulia N, Sahu SK, Stivers JT. Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages. Plos One. 15: e0235012. PMID 32663205 DOI: 10.1371/Journal.Pone.0235012 |
0.432 |
|
| 2019 |
Rodriguez G, Orris B, Majumdar A, Bhat S, Stivers JT. Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2. Dna Repair. 86: 102764. PMID 31855846 DOI: 10.1016/J.Dnarep.2019.102764 |
0.573 |
|
| 2019 |
Cui J, Gizzi A, Stivers JT. Deoxyuridine in DNA has an inhibitory and promutagenic effect on RNA transcription by diverse RNA polymerases. Nucleic Acids Research. PMID 30892639 DOI: 10.1093/Nar/Gkz183 |
0.458 |
|
| 2018 |
Esadze A, Stivers JT. Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation. Chemical Reviews. PMID 30379068 DOI: 10.1021/Acs.Chemrev.8B00513 |
0.572 |
|
| 2018 |
Weiser BP, Rodriguez G, Cole PA, Stivers JT. N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Research. PMID 29917162 DOI: 10.1093/Nar/Gky525 |
0.584 |
|
| 2018 |
Weiser BP, Rodriguez G, Esadze A, Cole PA, Stivers JT. Function of the Intrinsically Disordered N-Terminus of Uracil DNA Glycosylase Biophysical Journal. 114: 82a. DOI: 10.1016/J.Bpj.2017.11.494 |
0.461 |
|
| 2017 |
Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT. Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. Nucleic Acids Research. PMID 29036472 DOI: 10.1093/Nar/Gkx848 |
0.645 |
|
| 2017 |
Rodriguez G, Esadze A, Weiser BP, Schonhoft J, Cole PA, Stivers JT. Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation. Acs Chemical Biology. PMID 28787572 DOI: 10.1021/Acschembio.7B00521 |
0.577 |
|
| 2017 |
Weiser BP, Stivers JT, Cole PA. Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis. Biophysical Journal. 113: 393-401. PMID 28746850 DOI: 10.1016/J.Bpj.2017.06.016 |
0.538 |
|
| 2017 |
Esadze A, Rodriguez G, Cravens SL, Stivers JT. APE1 Accelerates Turnover of hOGG1 by Preventing Retrograde Binding to the Abasic Site Product. Biochemistry. PMID 28345889 DOI: 10.1021/Acs.Biochem.7B00017 |
0.592 |
|
| 2016 |
Seamon KJ, Bumpus NN, Stivers JT. Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer. Biochemistry. PMID 27775344 DOI: 10.1021/Acs.Biochem.6B00986 |
0.443 |
|
| 2016 |
Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Capoferri AA, Bruner KM, Pollack RA, Zhang H, Drummond MB, Siliciano JM, Siliciano R, Stivers JT. Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells. Elife. 5. PMID 27644592 DOI: 10.7554/Elife.18447 |
0.506 |
|
| 2016 |
Cravens SL, Stivers JT. Comparative Effects of Ions, Molecular Crowding, and Bulk DNA on the Damage Search Mechanisms of hOGG1 and hUNG. Biochemistry. PMID 27571472 DOI: 10.1021/Acs.Biochem.6B00482 |
0.659 |
|
| 2016 |
Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Capoferri AA, Bruner KM, Pollack RA, Zhang H, Drummond MB, Siliciano JM, Siliciano R, Stivers JT. Author response: Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells Elife. DOI: 10.7554/Elife.18447.030 |
0.421 |
|
| 2016 |
Cravens SL, Stivers JT. Differential Effects of Ions, Molecular Crowding, and Solution DNA Density on the Damage Search Mechanisms of hOGG1 and hUNG Biophysical Journal. 110: 64a. DOI: 10.1016/J.Bpj.2015.11.412 |
0.67 |
|
| 2015 |
Seamon KJ, Sun Z, Shlyakhtenko LS, Lyubchenko YL, Stivers JT. SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity. Nucleic Acids Research. PMID 26101257 DOI: 10.1093/Nar/Gkv633 |
0.437 |
|
| 2015 |
Cravens SL, Schonhoft JD, Rowland MM, Rodriguez AA, Anderson BG, Stivers JT. Molecular crowding enhances facilitated diffusion of two human DNA glycosylases. Nucleic Acids Research. 43: 4087-97. PMID 25845592 DOI: 10.1016/J.Bpj.2014.11.450 |
0.643 |
|
| 2015 |
Seamon KJ, Stivers JT. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. Journal of Biomolecular Screening. 20: 801-9. PMID 25755265 DOI: 10.1177/1087057115575150 |
0.461 |
|
| 2014 |
Cravens SL, Hobson M, Stivers JT. Electrostatic properties of complexes along a DNA glycosylase damage search pathway. Biochemistry. 53: 7680-92. PMID 25408964 DOI: 10.1021/Bi501011M |
0.648 |
|
| 2014 |
Gajula KS, Huwe PJ, Mo CY, Crawford DJ, Stivers JT, Radhakrishnan R, Kohli RM. High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase. Nucleic Acids Research. 42: 9964-75. PMID 25064858 DOI: 10.1093/Nar/Gku689 |
0.539 |
|
| 2014 |
Rowland MM, Schonhoft JD, McKibbin PL, David SS, Stivers JT. Microscopic mechanism of DNA damage searching by hOGG1. Nucleic Acids Research. 42: 9295-303. PMID 25016526 DOI: 10.1093/Nar/Gku621 |
0.647 |
|
| 2014 |
Seamon KJ, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT. Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. Journal of the American Chemical Society. 136: 9822-5. PMID 24983818 DOI: 10.1021/Ja5035717 |
0.326 |
|
| 2014 |
Anderson BG, Stivers JT. Variola type IB DNA topoisomerase: DNA binding and supercoil unwinding using engineered DNA minicircles. Biochemistry. 53: 4302-15. PMID 24945825 DOI: 10.1021/Bi500571Q |
0.669 |
|
| 2014 |
Hansen EC, Seamon KJ, Cravens SL, Stivers JT. GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state. Proceedings of the National Academy of Sciences of the United States of America. 111: E1843-51. PMID 24753578 DOI: 10.1073/Pnas.1401706111 |
0.337 |
|
| 2013 |
Schonhoft JD, Kosowicz JG, Stivers JT. Correction to DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge. Biochemistry. 52: 8599. PMID 24228628 DOI: 10.1021/Bi401512A |
0.615 |
|
| 2013 |
Schonhoft JD, Kosowicz JG, Stivers JT. DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge. Biochemistry. 52: 2526-35. PMID 23506309 DOI: 10.1021/Bi301561D |
0.663 |
|
| 2013 |
Schonhoft JD, Stivers JT. DNA translocation by human uracil DNA glycosylase: the case of single-stranded DNA and clustered uracils. Biochemistry. 52: 2536-44. PMID 23506270 DOI: 10.1021/Bi301562N |
0.632 |
|
| 2013 |
Weil AF, Ghosh D, Zhou Y, Seiple L, McMahon MA, Spivak AM, Siliciano RF, Stivers JT. Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration. Proceedings of the National Academy of Sciences of the United States of America. 110: E448-57. PMID 23341616 DOI: 10.1073/Pnas.1219702110 |
0.771 |
|
| 2012 |
Ye Y, Stahley MR, Xu J, Friedman JI, Sun Y, McKnight JN, Gray JJ, Bowman GD, Stivers JT. Enzymatic excision of uracil residues in nucleosomes depends on the local DNA structure and dynamics. Biochemistry. 51: 6028-38. PMID 22784353 DOI: 10.1021/Bi3006412 |
0.63 |
|
| 2012 |
Nabel CS, Jia H, Ye Y, Shen L, Goldschmidt HL, Stivers JT, Zhang Y, Kohli RM. AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. Nature Chemical Biology. 8: 751-8. PMID 22772155 DOI: 10.1038/Nchembio.1042 |
0.576 |
|
| 2012 |
Jun H, Stivers JT. Diverse energetic effects of charge reversal mutations of poxvirus topoisomerase IB. Biochemistry. 51: 2940-9. PMID 22417571 DOI: 10.1021/Bi3001903 |
0.565 |
|
| 2012 |
Schonhoft JD, Stivers JT. Timing facilitated site transfer of an enzyme on DNA. Nature Chemical Biology. 8: 205-10. PMID 22231272 DOI: 10.1038/Nchembio.764 |
0.674 |
|
| 2011 |
Sun Y, Friedman JI, Stivers JT. Cosolute paramagnetic relaxation enhancements detect transient conformations of human uracil DNA glycosylase (hUNG). Biochemistry. 50: 10724-31. PMID 22077282 DOI: 10.1021/Bi201572G |
0.657 |
|
| 2011 |
Lauzon CB, van Zijl P, Stivers JT. Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease. Journal of Biomolecular Nmr. 50: 299-314. PMID 21809183 DOI: 10.1007/S10858-011-9527-Z |
0.315 |
|
| 2011 |
Feng Y, Xie N, Jin M, Stahley MR, Stivers JT, Zheng YG. A transient kinetic analysis of PRMT1 catalysis. Biochemistry. 50: 7033-44. PMID 21736313 DOI: 10.1021/Bi200456U |
0.318 |
|
| 2011 |
Grogan BC, Parker JB, Guminski AF, Stivers JT. Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. Biochemistry. 50: 618-27. PMID 21222484 DOI: 10.1021/Bi102046H |
0.599 |
|
| 2011 |
Parker JB, Stivers JT. Dynamics of uracil and 5-fluorouracil in DNA. Biochemistry. 50: 612-7. PMID 21190322 DOI: 10.1021/Bi101536K |
0.571 |
|
| 2011 |
Friedman JI, Jiang YL, Miller PS, Stivers JT. Unique dynamic properties of DNA duplexes containing interstrand cross-links. Biochemistry. 50: 882-90. PMID 21174443 DOI: 10.1021/Bi101813H |
0.605 |
|
| 2011 |
Schonhoft JD, Stivers JT. A kinetic Trapping Method for Evaluating One and Three Dimensional Target Site Location Mechanisms of Human Uracil DNA Glycosylase (UNG) Biophysical Journal. 100: 72a. DOI: 10.1016/J.Bpj.2010.12.593 |
0.663 |
|
| 2010 |
Kohli RM, Maul RW, Guminski AF, McClure RL, Gajula KS, Saribasak H, McMahon MA, Siliciano RF, Gearhart PJ, Stivers JT. Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. The Journal of Biological Chemistry. 285: 40956-64. PMID 20929867 DOI: 10.1074/Jbc.M110.177402 |
0.387 |
|
| 2010 |
Friedman JI, Stivers JT. Detection of damaged DNA bases by DNA glycosylase enzymes. Biochemistry. 49: 4957-67. PMID 20469926 DOI: 10.1021/Bi100593A |
0.624 |
|
| 2010 |
Ye Y, Stivers JT. Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1. Analytical Biochemistry. 401: 168-72. PMID 20197058 DOI: 10.1016/J.Ab.2010.02.032 |
0.591 |
|
| 2010 |
Stahley MR, Stivers JT. Mechanism and specificity of DNA strand exchange catalyzed by vaccinia DNA topoisomerase type I. Biochemistry. 49: 2786-95. PMID 20187656 DOI: 10.1021/Bi902204V |
0.676 |
|
| 2009 |
Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. The Journal of Biological Chemistry. 284: 22898-904. PMID 19561087 DOI: 10.1074/Jbc.M109.025536 |
0.418 |
|
| 2009 |
Chung S, Parker JB, Bianchet M, Amzel LM, Stivers JT. Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nature Chemical Biology. 5: 407-13. PMID 19396178 DOI: 10.1038/Nchembio.163 |
0.426 |
|
| 2009 |
Friedman JI, Majumdar A, Stivers JT. Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage. Nucleic Acids Research. 37: 3493-500. PMID 19339520 DOI: 10.1093/Nar/Gkp161 |
0.632 |
|
| 2009 |
Huang H, Stivers JT, Greenberg MM. Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase. Journal of the American Chemical Society. 131: 1344-5. PMID 19173657 DOI: 10.1021/Ja807705Z |
0.662 |
|
| 2009 |
Stivers JT. Erratum: Corrigendum: Small molecule versus DNA repair nanomachine Nature Chemical Biology. 5: 191-191. DOI: 10.1038/Nchembio0309-191B |
0.58 |
|
| 2008 |
Porecha RH, Stivers JT. Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils. Proceedings of the National Academy of Sciences of the United States of America. 105: 10791-6. PMID 18669665 DOI: 10.1073/Pnas.0801612105 |
0.849 |
|
| 2008 |
Parker JB, Stivers JT. Uracil DNA glycosylase: revisiting substrate-assisted catalysis by DNA phosphate anions. Biochemistry. 47: 8614-22. PMID 18652484 DOI: 10.1021/Bi800854G |
0.649 |
|
| 2008 |
Kim H, Cardellina JH, Akee R, Champoux JJ, Stivers JT. Arylstibonic acids: novel inhibitors and activators of human topoisomerase IB. Bioorganic Chemistry. 36: 190-7. PMID 18508107 DOI: 10.1016/J.Bioorg.2008.04.001 |
0.606 |
|
| 2008 |
Stivers JT. Small molecule versus DNA repair nanomachine. Nature Chemical Biology. 4: 86-8. PMID 18202674 DOI: 10.1038/Nchembio0208-86 |
0.588 |
|
| 2008 |
Seiple LA, Cardellina JH, Akee R, Stivers JT. Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids. Molecular Pharmacology. 73: 669-77. PMID 18042731 DOI: 10.1124/Mol.107.042622 |
0.783 |
|
| 2008 |
Stivers JT. Extrahelical damaged base recognition by DNA glycosylase enzymes. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 786-93. PMID 18000994 DOI: 10.1002/Chem.200701501 |
0.627 |
|
| 2007 |
Parker JB, Bianchet MA, Krosky DJ, Friedman JI, Amzel LM, Stivers JT. Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature. 449: 433-7. PMID 17704764 DOI: 10.1038/Nature06131 |
0.818 |
|
| 2007 |
Nagarajan R, Stivers JT. Unmasking Anticooperative DNA-binding interactions of vaccinia DNA topoisomerase I. Biochemistry. 46: 192-9. PMID 17198389 DOI: 10.1021/Bi061706U |
0.616 |
|
| 2007 |
Porecha RH, Stivers JT. Damage site location by uracil DNA glycosylase involves short‐range sliding and efficient DNA hopping The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A657 |
0.845 |
|
| 2006 |
Krosky DJ, Bianchet MA, Seiple L, Chung S, Amzel LM, Stivers JT. Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Research. 34: 5872-9. PMID 17062624 DOI: 10.1093/Nar/Gkl747 |
0.821 |
|
| 2006 |
Cao C, Jiang YL, Krosky DJ, Stivers JT. The catalytic power of uracil DNA glycosylase in the opening of thymine base pairs. Journal of the American Chemical Society. 128: 13034-5. PMID 17017766 DOI: 10.1021/Ja062978N |
0.834 |
|
| 2006 |
Stivers JT, Nagarajan R. Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens. Chemical Reviews. 106: 3443-67. PMID 16895336 DOI: 10.1021/Cr050317N |
0.378 |
|
| 2006 |
Jiang YL, Chung S, Krosky DJ, Stivers JT. Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2. Bioorganic & Medicinal Chemistry. 14: 5666-72. PMID 16678429 DOI: 10.1016/J.Bmc.2006.04.022 |
0.824 |
|
| 2006 |
Nagarajan R, Stivers JT. Major groove interactions of vaccinia Topo I provide specificity by optimally positioning the covalent phosphotyrosine linkage. Biochemistry. 45: 5775-82. PMID 16669621 DOI: 10.1021/Bi060133I |
0.587 |
|
| 2006 |
Seiple L, Jaruga P, Dizdaroglu M, Stivers JT. Linking uracil base excision repair and 5-fluorouracil toxicity in yeast. Nucleic Acids Research. 34: 140-51. PMID 16407331 DOI: 10.1093/Nar/Gkj430 |
0.814 |
|
| 2006 |
Bond A, Reichert Z, Stivers JT. Novel and specific inhibitors of a poxvirus type I topoisomerase. Molecular Pharmacology. 69: 547-57. PMID 16267207 DOI: 10.1124/Mol.105.019067 |
0.468 |
|
| 2006 |
Stivers JT, Kuchta RD. Introduction: DNA damage and repair Chemical Reviews. 106: 213-214. DOI: 10.1021/Cr0404949 |
0.593 |
|
| 2005 |
Jiang YL, Krosky DJ, Seiple L, Stivers JT. Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development. Journal of the American Chemical Society. 127: 17412-20. PMID 16332091 DOI: 10.1021/Ja055846N |
0.814 |
|
| 2005 |
Nagarajan R, Kwon K, Nawrot B, Stec WJ, Stivers JT. Catalytic phosphoryl interactions of topoisomerase IB. Biochemistry. 44: 11476-85. PMID 16114884 DOI: 10.1021/Bi050796K |
0.334 |
|
| 2005 |
Krosky DJ, Song F, Stivers JT. The origins of high-affinity enzyme binding to an extrahelical DNA base. Biochemistry. 44: 5949-59. PMID 15835884 DOI: 10.1021/Bi050084U |
0.848 |
|
| 2004 |
Stivers JT. Comment on "Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch". Science (New York, N.Y.). 306: 2042; author reply 2. PMID 15604391 DOI: 10.1126/Science.1104396 |
0.413 |
|
| 2004 |
Jiang YL, McDowell LM, Poliks B, Studelska DR, Cao C, Potter GS, Schaefer J, Song F, Stivers JT. Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase. Biochemistry. 43: 15429-38. PMID 15581354 DOI: 10.1021/Bi0483864 |
0.49 |
|
| 2004 |
Cao C, Jiang YL, Stivers JT, Song F. Dynamic opening of DNA during the enzymatic search for a damaged base. Nature Structural & Molecular Biology. 11: 1230-6. PMID 15558051 DOI: 10.1038/Nsmb864 |
0.635 |
|
| 2004 |
Kwon K, Nagarajan R, Stivers JT. Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay. Biochemistry. 43: 14994-5004. PMID 15554707 DOI: 10.1021/Bi048801S |
0.573 |
|
| 2004 |
Jiang YL, Cao C, Stivers JT, Song F, Ichikawa Y. The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase. Bioorganic Chemistry. 32: 244-62. PMID 15210339 DOI: 10.1016/J.Bioorg.2004.03.001 |
0.528 |
|
| 2004 |
Stivers JT. Site-specific DNA damage recognition by enzyme-induced base flipping. Progress in Nucleic Acid Research and Molecular Biology. 77: 37-65. PMID 15196890 DOI: 10.1016/S0079-6603(04)77002-6 |
0.668 |
|
| 2004 |
Krosky DJ, Schwarz FP, Stivers JT. Linear free energy correlations for enzymatic base flipping: how do damaged base pairs facilitate specific recognition? Biochemistry. 43: 4188-95. PMID 15065862 DOI: 10.1021/Bi036303Y |
0.831 |
|
| 2003 |
Bianchet MA, Seiple LA, Jiang YL, Ichikawa Y, Amzel LM, Stivers JT. Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase. Biochemistry. 42: 12455-60. PMID 14580190 DOI: 10.1021/Bi035372+ |
0.81 |
|
| 2003 |
Cao C, Kwon K, Jiang YL, Drohat AC, Stivers JT. Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I. The Journal of Biological Chemistry. 278: 48012-20. PMID 13129925 DOI: 10.1074/Jbc.M307500200 |
0.6 |
|
| 2003 |
Stivers JT, Jiang YL. A mechanistic perspective on the chemistry of DNA repair glycosylases. Chemical Reviews. 103: 2729-59. PMID 12848584 DOI: 10.1021/Cr010219B |
0.62 |
|
| 2003 |
Kwon K, Jiang YL, Stivers JT. Rational engineering of a DNA glycosylase specific for an unnatural cytosine:pyrene base pair. Chemistry & Biology. 10: 351-9. PMID 12725863 DOI: 10.1016/S1074-5521(03)00077-2 |
0.652 |
|
| 2003 |
Kwon K, Cao C, Stivers JT. A novel zinc snap motif conveys structural stability to 3-methyladenine DNA glycosylase I. The Journal of Biological Chemistry. 278: 19442-6. PMID 12654914 DOI: 10.1074/Jbc.M300934200 |
0.579 |
|
| 2003 |
Jiang YL, Ichikawa Y, Song F, Stivers JT. Powering DNA repair through substrate electrostatic interactions. Biochemistry. 42: 1922-9. PMID 12590578 DOI: 10.1021/Bi027014X |
0.538 |
|
| 2003 |
Jiang YL, Stivers JT. Novel Epimerization of Aromatic C-Nucleosides with Electron-Withdrawing Substituents with Trifluoroacetic Acid-Benzenesulfonic Acid Using Mild Conditions. Cheminform. 34. DOI: 10.1016/S0040-4039(03)00848-7 |
0.317 |
|
| 2002 |
Jiang YL, Stivers JT, Song F. Base-flipping mutations of uracil DNA glycosylase: substrate rescue using a pyrene nucleotide wedge. Biochemistry. 41: 11248-54. PMID 12220190 DOI: 10.1021/Bi026227J |
0.52 |
|
| 2002 |
Jiang YL, Stivers JT. Mutational analysis of the base-flipping mechanism of uracil DNA glycosylase. Biochemistry. 41: 11236-47. PMID 12220189 DOI: 10.1021/Bi026226R |
0.634 |
|
| 2002 |
Drohat AC, Kwon K, Krosky DJ, Stivers JT. 3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member. Nature Structural Biology. 9: 659-64. PMID 12161745 DOI: 10.1038/Nsb829 |
0.834 |
|
| 2002 |
Jiang YL, Ichikawa Y, Stivers JT. Inhibition of uracil DNA glycosylase by an oxacarbenium ion mimic. Biochemistry. 41: 7116-24. PMID 12033946 DOI: 10.1021/Bi025694Y |
0.478 |
|
| 2002 |
Jiang YL, Drohat AC, Ichikawa Y, Stivers JT. Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis. The Journal of Biological Chemistry. 277: 15385-92. PMID 11859082 DOI: 10.1074/Jbc.M200634200 |
0.594 |
|
| 2002 |
Kwon K, Jiang YL, Song F, Stivers JT. 19F NMR studies of vaccinia type IB topoisomerase. Conformational dynamics of the bound DNA substrate. The Journal of Biological Chemistry. 277: 353-8. PMID 11689573 DOI: 10.1074/Jbc.M109450200 |
0.531 |
|
| 2002 |
Kwon K, Stivers JT. Fluorescence spectroscopy studies of vaccinia type IB DNA topoisomerase. Closing of the enzyme clamp is faster than DNA cleavage. The Journal of Biological Chemistry. 277: 345-52. PMID 11689572 DOI: 10.1074/Jbc.M109449200 |
0.653 |
|
| 2001 |
Stivers JT, Drohat AC. Uracil DNA glycosylase: insights from a master catalyst. Archives of Biochemistry and Biophysics. 396: 1-9. PMID 11716455 DOI: 10.1006/Abbi.2001.2605 |
0.628 |
|
| 2001 |
Jiang YL, Kwon K, Stivers JT. Turning On uracil-DNA glycosylase using a pyrene nucleotide switch. The Journal of Biological Chemistry. 276: 42347-54. PMID 11551943 DOI: 10.1074/Jbc.M106594200 |
0.674 |
|
| 2001 |
Jiang YL, Stivers JT. Reconstructing the substrate for uracil DNA glycosylase: tracking the transmission of binding energy in catalysis. Biochemistry. 40: 7710-9. PMID 11412125 DOI: 10.1021/Bi010622C |
0.437 |
|
| 2001 |
Rachofsky EL, Seibert E, Stivers JT, Osman R, Ross JB. Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine. Biochemistry. 40: 957-67. PMID 11170417 DOI: 10.1021/Bi001665G |
0.527 |
|
| 2000 |
Werner RM, Stivers JT. Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: Evidence for an oxocarbenium ion - Uracil anion intermediate Biochemistry. 39: 14054-14064. PMID 11087352 DOI: 10.1021/Bi0018178 |
0.449 |
|
| 2000 |
Dong J, Drohat AC, Stivers JT, Pankiewicz KW, Carey PR. Raman spectroscopy of uracil DNA glycosylase-DNA complexes: Insights into DNA damage recognition and catalysis Biochemistry. 39: 13241-13250. PMID 11052677 DOI: 10.1021/Bi001437M |
0.652 |
|
| 2000 |
Werner RM, Jiang YL, Gordley RG, Jagadeesh GJ, Ladner JE, Xiao G, Tordova M, Gilliland GL, Stivers JT. Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase Biochemistry. 39: 12585-12594. PMID 11027138 DOI: 10.1021/bi001532v |
0.524 |
|
| 2000 |
Drohat AC, Stivers JT. Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2. Biochemistry. 39: 11865-75. PMID 11009598 DOI: 10.1021/Bi000922E |
0.368 |
|
| 2000 |
Stivers JT, Jagadeesh GJ, Nawrot B, Stec WJ, Shuman S. Stereochemical outcome and kinetic effects of Rp- and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase. Biochemistry. 39: 5561-72. PMID 10820030 DOI: 10.1021/Bi992429C |
0.485 |
|
| 2000 |
Lacourciere KA, Stivers JT, Marino JP. Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy. Biochemistry. 39: 5630-41. PMID 10801313 DOI: 10.1021/Bi992932P |
0.339 |
|
| 2000 |
Drohat AC, Stivers JT. NMR evidence for an unusually low N1 pK(a) for uracil bound to uracil DNA glycosylase: Implications for catalysis [20] Journal of the American Chemical Society. 122: 1840-1841. DOI: 10.1021/Ja993254X |
0.536 |
|
| 1999 |
Drohat AC, Xiao G, Tordova M, Jagadeesh J, Pankiewicz KW, Watanabe KA, Gilliland GL, Stivers JT. Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187. Biochemistry. 38: 11876-86. PMID 10508390 DOI: 10.1021/Bi9910880 |
0.434 |
|
| 1999 |
Drohat AC, Jagadeesh J, Ferguson E, Stivers JT. Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase. Biochemistry. 38: 11866-75. PMID 10508389 DOI: 10.1021/Bi9910878 |
0.493 |
|
| 1999 |
Czerwinski RM, Harris TK, Johnson WH, Legler PM, Stivers JT, Mildvan AS, Whitman CP. Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis. Biochemistry. 38: 12358-66. PMID 10493803 DOI: 10.1021/Bi9911177 |
0.308 |
|
| 1999 |
Harris TK, Czerwinski RM, Johnson WH, Legler PM, Abeygunawardana C, Massiah MA, Stivers JT, Whitman CP, Mildvan AS. Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase. Biochemistry. 38: 12343-57. PMID 10493802 DOI: 10.1021/Bi991116E |
0.322 |
|
| 1999 |
Xiao G, Tordova M, Jagadeesh J, Drohat AC, Stivers JT, Gilliland GL. Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited. Proteins. 35: 13-24. PMID 10090282 DOI: 10.1002/(Sici)1097-0134(19990401)35:1<13::Aid-Prot2>3.0.Co;2-2 |
0.567 |
|
| 1999 |
Stivers JT, Pankiewicz KW, Watanabe KA. Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase. Biochemistry. 38: 952-63. PMID 9893991 DOI: 10.1021/Bi9818669 |
0.659 |
|
| 1998 |
Stivers JT. 2-Aminopurine fluorescence studies of base stacking interactions at abasic sites in DNA: metal-ion and base sequence effects. Nucleic Acids Research. 26: 3837-44. PMID 9685503 DOI: 10.1093/Nar/26.16.3837 |
0.456 |
|
| 1997 |
Stivers JT, Harris TK, Mildvan AS. Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation. Biochemistry. 36: 5212-22. PMID 9136883 DOI: 10.1021/Bi962880T |
0.6 |
|
| 1996 |
Stivers JT, Abeygunawardana C, Mildvan AS. 15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: backbone dynamics and entropy changes of an enzyme upon inhibitor binding. Biochemistry. 35: 16036-47. PMID 8973173 DOI: 10.1021/Bi961834Q |
0.332 |
|
| 1996 |
Stivers JT, Abeygunawardana C, Whitman CP, Mildvan AS. 4-Oxalocrotonate tautomerase, a 41-kDa homohexamer: backbone and side-chain resonance assignments, solution secondary structure, and location of active site residues by heteronuclear NMR spectroscopy. Protein Science : a Publication of the Protein Society. 5: 729-41. PMID 8845763 DOI: 10.1002/Pro.5560050418 |
0.3 |
|
| 1996 |
Sekiguchi J, Stivers JT, Mildvan AS, Shuman S. Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin. The Journal of Biological Chemistry. 271: 2313-22. PMID 8567695 DOI: 10.1074/Jbc.271.4.2313 |
0.598 |
|
| 1996 |
Stivers JT, Abeygunawardana C, Mildvan AS, Hajipour G, Whitman CP. 4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues. Biochemistry. 35: 814-23. PMID 8547261 DOI: 10.1021/Bi9510789 |
0.304 |
|
| 1996 |
Stivers JT, Abeygunawardana C, Mildvan AS, Hajipour G, Whitman CP, Chen LH. Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies. Biochemistry. 35: 803-13. PMID 8547260 DOI: 10.1021/Bi951077G |
0.311 |
|
| 1994 |
Stivers JT, Shuman S, Mildvan AS. Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions. Biochemistry. 33: 327-39. PMID 8286354 DOI: 10.1021/Bi00167A043 |
0.614 |
|
| 1994 |
Stivers JT, Shuman S, Mildvan AS. Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step. Biochemistry. 33: 15449-58. PMID 7803409 DOI: 10.1021/Bi00255A027 |
0.437 |
|
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