Sanjay Awasthi - Publications

Affiliations: 
2016- Internal Medicine, Division of Heme/Onc Texas Tech University Health Sciences Center, Lubbock, TX 
Area:
Biochemistry; Glutathione; Ralbp1; TP53; Antioxidants; Cacinogenesis

203 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ramisetty SK, Garg P, Mohanty A, Mirzapoiazova T, Yue E, Wang E, Horne D, Awasthi S, Kulkarni P, Salgia R, Singhal SS. Regression of ovarian cancer xenografts by depleting or inhibiting RLIP. Biochemical Pharmacology. 217: 115847. PMID 37804871 DOI: 10.1016/j.bcp.2023.115847  0.763
2023 Garg P, Awasthi S, Horne D, Salgia R, Singhal SS. The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action. Biochimica Et Biophysica Acta. Reviews On Cancer. 188929. PMID 37286146 DOI: 10.1016/j.bbcan.2023.188929  0.736
2023 Garg P, Garg R, Horne D, Awasthi S, Salgia R, Singhal SS. Prognostic significance of natural products against multidrug tumor resistance. Cancer Letters. 557: 216079. PMID 36736532 DOI: 10.1016/j.canlet.2023.216079  0.728
2022 Singhal SS, Garg R, Horne D, Singhal S, Awasthi S, Salgia R. RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling. Biochimica Et Biophysica Acta. Reviews On Cancer. 188803. PMID 36150564 DOI: 10.1016/j.bbcan.2022.188803  0.76
2022 Nagaprashantha LD, Singhal J, Li H, Warden C, Liu X, Horne D, Awasthi S, Salgia R, Singhal SS. Correction: 2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer. Oncotarget. 13: 331. PMID 35261722 DOI: 10.18632/oncotarget.28199  0.737
2021 Bose C, Hindle A, Lee J, Kopel J, Tonk S, Palade PT, Singhal SS, Awasthi S, Singh SP. Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells. Cancers. 13. PMID 34944997 DOI: 10.3390/cancers13246377  0.757
2021 Singh SP, Lee J, Bose C, Li H, Yuan YC, Hindle A, Singhal SS, Kopel J, Palade PT, Jones C, Rahman RL, Awasthi S. Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis. Cancers. 13. PMID 34283045 DOI: 10.3390/cancers13133329  0.746
2021 Singhal SS, Srivastava S, Mirzapoiazova T, Horne D, Awasthi S, Salgia R. Targeting the mercapturic acid pathway for the treatment of melanoma. Cancer Letters. PMID 34126193 DOI: 10.1016/j.canlet.2021.06.004  0.756
2021 Singhal SS, Mohanty A, Kulkarni P, Horne D, Awasthi S, Salgia R. RLIP Depletion Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells. Carcinogenesis. PMID 33623991 DOI: 10.1093/carcin/bgab016  0.792
2021 Singhal J, Kulkarni P, Horne D, Awasthi S, Salgia R, Singhal SS. Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP. Molecular Carcinogenesis. PMID 33544936 DOI: 10.1002/mc.23285  0.75
2021 Singhal SS, Horne D, Singhal J, Awasthi S, Salgia R. Activating p53 function by targeting RLIP. Biochimica Et Biophysica Acta. Reviews On Cancer. 188512. PMID 33460725 DOI: 10.1016/j.bbcan.2021.188512  0.765
2020 Bose C, Yadav S, Singhal SS, Singhal J, Hindle A, Lee J, Cheedella NKS, Rehman S, Rahman RL, Jones C, Darden M, Palade PT, Berz D, Singh SP, Awasthi S. Rlip Depletion Suppresses Growth of Breast Cancer. Cancers. 12. PMID 32498332 DOI: 10.3390/Cancers12061446  0.765
2020 Singhal J, Chikara S, Horne D, Awasthi S, Salgia R, Singhal SS. Targeting RLIP with CRISPR/Cas9 controls tumor growth. Carcinogenesis. PMID 32426802 DOI: 10.1093/Carcin/Bgaa048  0.757
2020 Jana S, Krishna M, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. Therapeutic targeting of miRNA-216b in cancer. Cancer Letters. 484: 16-28. PMID 32387443 DOI: 10.1016/J.Canlet.2020.04.020  0.724
2020 Krishna BM, Jana S, Panda AK, Horne D, Awasthi S, Salgia R, Singhal SS. Association of Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case-Control Studies †. Cancers. 12. PMID 32085560 DOI: 10.3390/Cancers12020471  0.695
2020 Jana S, Krishna BM, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. SOX9: The Master Regulator of Cell Fate in Breast Cancer. Biochemical Pharmacology. 113789. PMID 31911091 DOI: 10.1016/J.Bcp.2019.113789  0.748
2020 Singhal SS, Salgia R, Verma N, Horne D, Awasthi S. RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis. Biochimica Et Biophysica Acta. Reviews On Cancer. 1873: 188337. PMID 31904398 DOI: 10.1016/J.Bbcan.2020.188337  0.749
2019 Bose C, Singh SP, Igid H, Green WC, Singhal SS, Lee J, Palade PT, Rajan A, Ball S, Tonk V, Hindle A, Tarbox M, Awasthi S. Topical 2'-Hydroxyflavanone for Cutaneous Melanoma. Cancers. 11. PMID 31615091 DOI: 10.3390/Cancers11101556  0.742
2019 Krishna BM, Jana S, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. Notch signaling in breast cancer: From pathway analysis to therapy. Cancer Letters. 461: 123-131. PMID 31326555 DOI: 10.1016/J.Canlet.2019.07.012  0.753
2019 Singhal SS, Horne D, Singhal J, Vonderfecht S, Salgia R, Awasthi S. Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice. Molecular Carcinogenesis. PMID 31006917 DOI: 10.1002/Mc.23026  0.738
2019 Singhal SS, Salgia R, Singhal S, Horne D, Awasthi S. RLIP: An existential requirement for breast carcinogenesis. Biochimica Et Biophysica Acta. Reviews On Cancer. 1871: 281-288. PMID 30771458 DOI: 10.1016/J.Bbcan.2019.02.001  0.788
2019 Singhal J, Chikara S, Horne D, Salgia R, Awasthi S, Singhal SS. RLIP inhibition suppresses breast-to-lung metastasis. Cancer Letters. 447: 24-32. PMID 30684594 DOI: 10.1016/J.Canlet.2019.01.023  0.742
2018 Awasthi S, Singhal SS, Singhal J, Nagaprashantha L, Li H, Yuan YC, Liu Z, Berz D, Igid H, Green WC, Tijani L, Tonk V, Rajan A, Awasthi Y, Singh SP. Anticancer activity of 2'-hydroxyflavanone towards lung cancer. Oncotarget. 9: 36202-36219. PMID 30546837 DOI: 10.18632/Oncotarget.26329  0.825
2018 Nagaprashantha LD, Singhal J, Chikara S, Gugiu G, Horne D, Awasthi S, Salgia R, Singhal SS. 2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells. Journal of Proteomics. PMID 30248461 DOI: 10.1016/J.Jprot.2018.09.005  0.764
2018 Singhal J, Singhal P, Horne D, Salgia R, Awasthi S, Singhal SS. Metastasis of Breast Tumor Cells to Brain is suppressed by Targeting RLIP alone and in combination with 2'-Hydroxyflavanone. Cancer Letters. PMID 30223070 DOI: 10.1016/J.Canlet.2018.09.015  0.748
2018 Singhal J, Chikara S, Horne D, Salgia R, Awasthi S, Singhal SS. 2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76. Molecular Carcinogenesis. PMID 30136444 DOI: 10.1002/Mc.22894  0.778
2018 Nagaprashantha LD, Singhal J, Li H, Warden C, Liu X, Horne D, Awasthi S, Salgia R, Singhal SS. 2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer. Oncotarget. 9: 18053-18068. PMID 29719590 DOI: 10.18632/Oncotarget.24720  0.779
2018 Awasthi S, Tompkins J, Singhal J, Riggs AD, Yadav S, Wu X, Singh S, Warden C, Liu Z, Wang J, Slavin TP, Weitzel JN, Yuan YC, Awasthi M, Srivastava SK, et al. Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29572430 DOI: 10.1073/Pnas.1719586115  0.814
2018 Thein KZ, Sultan A, Swarup S, Hardwicke FL, Jones C, Tijani LA, Awasthi S, D'Cunha NC. Incidence of pneumonitis in patients with solid tumors treated with everolimus: A systematic review and meta- analysis of randomized controlled trials. Journal of Clinical Oncology. 36. DOI: 10.1200/Jco.2018.36.15_Suppl.E22220  0.301
2018 Swarup S, Thein KZ, Sultan A, Khan S, Jones C, Hardwicke FL, Awasthi S. Risk of gastrointestinal and hepatic toxicities in patients with advanced breast cancer treated with everolimus: A meta- analysis of phase 3 randomized controlled trials. Journal of Clinical Oncology. 36. DOI: 10.1200/Jco.2018.36.15_Suppl.E22215  0.305
2018 Awasthi S. Effective prevention of cancer in p53 null mice by depleting Rlip. Journal of Clinical Oncology. 36. DOI: 10.1200/Jco.2018.36.15_Suppl.E13540  0.352
2017 Chikara S, Nagaprashantha LD, Singhal J, Horne D, Awasthi S, Singhal SS. Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment. Cancer Letters. PMID 29113871 DOI: 10.1016/J.Canlet.2017.11.002  0.76
2017 Singhal J, Nagaprashantha L, Chikara S, Awasthi S, Horne D, Singhal SS. 2'-Hydroxyflavanone: A novel strategy for targeting breast cancer. Oncotarget. 8: 75025-75037. PMID 29088842 DOI: 10.18632/Oncotarget.20499  0.765
2017 Nagaprashantha LD, Adhikari R, Singhal J, Chikara S, Awasthi S, Horne D, Singhal S. Translational Opportunities for Broad-Spectrum Natural Phytochemicals and Targeted Agent Combinations in Breast Cancer. International Journal of Cancer. PMID 28975625 DOI: 10.1002/Ijc.31085  0.754
2017 Sonowal H, Pal PB, Wen JJ, Awasthi S, Ramana KV, Srivastava SK. Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity. Scientific Reports. 7: 3182. PMID 28600556 DOI: 10.1038/s41598-017-03284-w  0.673
2017 Singhal SS, Nagaprashantha L, Singhal P, Singhal S, Singhal J, Awasthi S, Horne D. RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharmaceutical Research. PMID 28386633 DOI: 10.1007/S11095-017-2154-Y  0.778
2017 Singhal SS, Jain D, Singhal P, Awasthi S, Singhal J, Horne D. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. Biochimica Et Biophysica Acta. PMID 28359741 DOI: 10.1016/J.Bbcan.2017.03.009  0.755
2017 Singhal SS, Singhal S, Singhal P, Singhal J, Horne D, Awasthi S. Didymin: an orally active citrus flavonoid for targeting neuroblastoma. Oncotarget. PMID 28187004 DOI: 10.18632/Oncotarget.15204  0.763
2017 Yendala R, Tijani L, Thein KZ, Igid HP, Shanshal M, Awasthi S, Hardwicke FL. A novel function of SMC1 as a transporter of xenobiotics. Journal of Clinical Oncology. 35: e14107-e14107. DOI: 10.1200/Jco.2017.35.15_Suppl.E14107  0.449
2017 Khan MS, Hardwicke FL, Igid HP, Kaleem H, Awasthi S, Armstrong D. Screening for antineoplastic ionic liquids by targeting RLIP76. Journal of Clinical Oncology. 35: e13033-e13033. DOI: 10.1200/Jco.2017.35.15_Suppl.E13033  0.315
2016 Awasthi YC, Ramana KV, Chaudhary P, Srivastava SK, Awasthi S. Regulatory Roles of Glutathione-S-Transferases and 4-hydroxynonenal in Stress-mediated Signaling and Toxicity. Free Radical Biology & Medicine. PMID 27794453 DOI: 10.1016/J.Freeradbiomed.2016.10.493  0.768
2015 Figarola JL, Singhal J, Tompkins JD, Rogers GW, Warden C, Horne D, Riggs AD, Awasthi S, Singhal SS. SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMPK-mTOR Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells. The Journal of Biological Chemistry. PMID 26534958 DOI: 10.1074/Jbc.M115.686352  0.748
2015 Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochemical and Biophysical Research Communications. 467: 785-91. PMID 26498519 DOI: 10.1016/J.Bbrc.2015.10.064  0.707
2015 Singhal SS, Singh SP, Singhal P, Horne D, Singhal J, Awasthi S. Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling. Toxicology and Applied Pharmacology. PMID 26476300 DOI: 10.1016/J.Taap.2015.10.006  0.775
2015 Singhal SS, Singhal J, Figarola J, Horne D, Awasthi S. RLIP76 Targeted Therapy for Kidney Cancer. Pharmaceutical Research. 32: 3123-36. PMID 26021465 DOI: 10.1007/S11095-015-1723-1  0.783
2015 Singhal SS, Singhal J, Figarola JL, Riggs A, Horne D, Awasthi S. 2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention. Biochemical Pharmacology. 96: 151-8. PMID 25957660 DOI: 10.1016/J.Bcp.2015.04.022  0.761
2014 Figarola JL, Singhal J, Rahbar S, Awasthi S, Singhal SS. LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells. Apoptosis : An International Journal On Programmed Cell Death. 19: 776-88. PMID 24615331 DOI: 10.1007/S10495-014-0974-3  0.745
2014 Sahu M, Sharma R, Yadav S, Wakamiya M, Chaudhary P, Awasthi S, Awasthi YC. Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Experimental Eye Research. 118: 125-34. PMID 24188744 DOI: 10.1016/J.Exer.2013.10.018  0.629
2013 Figarola JL, Singhal P, Rahbar S, Gugiu BG, Awasthi S, Singhal SS. COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. Plos One. 8: e83801. PMID 24376752 DOI: 10.1371/Journal.Pone.0083801  0.723
2013 Singhal SS, Figarola J, Singhal J, Nagaprashantha L, Berz D, Rahbar S, Awasthi S. Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression. Biochemical Pharmacology. 86: 1664-72. PMID 24099794 DOI: 10.1016/J.Bcp.2013.09.022  0.787
2013 Nagaprashantha LD, Talamantes T, Singhal J, Guo J, Vatsyayan R, Rauniyar N, Awasthi S, Singhal SS, Prokai L. Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression. Plos One. 8: e71654. PMID 23940778 DOI: 10.1371/Journal.Pone.0071654  0.8
2013 Singhal SS, Figarola J, Singhal J, Reddy MA, Liu X, Berz D, Natarajan R, Awasthi S. RLIP76 protein knockdown attenuates obesity due to a high-fat diet. The Journal of Biological Chemistry. 288: 23394-406. PMID 23821548 DOI: 10.1074/Jbc.M113.480194  0.717
2013 Chaudhary P, Sharma R, Sahu M, Vishwanatha JK, Awasthi S, Awasthi YC. 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. The Journal of Biological Chemistry. 288: 20532-46. PMID 23733185 DOI: 10.1074/Jbc.M113.467662  0.644
2013 Yadav S, Sehrawat A, Eroglu Z, Somlo G, Hickey R, Yadav S, Liu X, Awasthi YC, Awasthi S. Role of SMC1 in overcoming drug resistance in triple negative breast cancer. Plos One. 8: e64338. PMID 23717600 DOI: 10.1371/Journal.Pone.0064338  0.657
2013 Yadav A, Janaratne T, Krishnan A, Singhal SS, Yadav S, Dayoub AS, Hawkins DL, Awasthi S, MacDonnell FM. Regression of lung cancer by hypoxia-sensitizing ruthenium polypyridyl complexes. Molecular Cancer Therapeutics. 12: 643-53. PMID 23443803 DOI: 10.1158/1535-7163.Mct-12-1130  0.755
2013 Sehrawat A, Yadav S, Awasthi YC, Basu A, Warden C, Awasthi S. P300 regulates the human RLIP76 promoter activity and gene expression. Biochemical Pharmacology. 85: 1203-11. PMID 23419874 DOI: 10.1016/J.Bcp.2013.02.012  0.63
2013 Vatsyayan R, Singhal J, Nagaprashantha LD, Awasthi S, Singhal SS. Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma. Molecular Carcinogenesis. 52: 39-48. PMID 22006587 DOI: 10.1002/Mc.20875  0.759
2012 Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, Lincoln C, Gabriel Gugiu B, Horne D, Jove R, Awasthi S, Rahbar S. 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. Biochemical Pharmacology. 84: 1419-27. PMID 22959823 DOI: 10.1016/J.Bcp.2012.08.020  0.764
2012 Lee S, Wurtzel JG, Singhal SS, Awasthi S, Goldfinger LE. RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Research. 72: 5165-73. PMID 22902412 DOI: 10.1158/0008-5472.Can-12-0468  0.723
2012 Sharma R, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC. Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. Free Radical Biology & Medicine. 52: 2177-85. PMID 22579574 DOI: 10.1016/J.Freeradbiomed.2012.04.012  0.675
2012 Leake K, Singhal J, Nagaprashantha LD, Awasthi S, Singhal SS. RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer. Plos One. 7: e34582. PMID 22509328 DOI: 10.1371/Journal.Pone.0034582  0.774
2012 Nagaprashantha L, Vartak N, Awasthi S, Awasthi S, Singhal SS. Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors. Pharmaceutical Research. 29: 621-36. PMID 22203324 DOI: 10.1007/S11095-011-0645-9  0.774
2012 Singhal J, Nagaprashantha LD, Vatsyayan R, Ashutosh, Awasthi S, Singhal SS. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prevention Research (Philadelphia, Pa.). 5: 473-83. PMID 22174364 DOI: 10.1158/1940-6207.Capr-11-0318  0.762
2012 Vatsyayan R, Lelsani PC, Chaudhary P, Kumar S, Awasthi S, Awasthi YC. The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4. Biochemical and Biophysical Research Communications. 417: 346-51. PMID 22155253 DOI: 10.1016/J.Bbrc.2011.11.113  0.634
2012 Dalasanur Nagaprashantha LPG, Talamantes T, Singhal J, Awasthi S, Singhal SS, Prokai L. The impact of novel compound 2'-hydroxyflavanone on proteomic networks of VHL-mutant renal cell carcinoma. Journal of Clinical Oncology. 30: e13557-e13557. DOI: 10.1200/Jco.2012.30.15_Suppl.E13557  0.779
2012 Nagaprashantha L, Singhal J, Awasthi S, Singhal SS. Abstract 3700: Anticancer effects and mechanisms of action of novel flavonoid didymin in neuroblastomas Cancer Research. 72: 3700-3700. DOI: 10.1158/1538-7445.Am2012-3700  0.776
2012 Singhal SS, Nagaprashantha L, Singhal J, Awasthi S. Abstract 2697: Role of a novel flavonoid enriched in ocimum sanctum linn for prostate cancer chemoprevention and therapy Cancer Research. 72: 2697-2697. DOI: 10.1158/1538-7445.Am2012-2697  0.766
2011 Dalasanur Nagaprashantha LP, Singhal J, Vatsyayan R, Awasthi S, Singhal SS. The impact of a novel vicenin-2 and oral docetaxel combinatorial regimen in androgen-independent prostate cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: e13534. PMID 28022720 DOI: 10.1200/jco.2011.29.15_suppl.e13534  0.751
2011 Kumar S, Kokate RA, Sahu M, Chaudhary P, Sharma R, Awasthi S, Awasthi YC. Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice. Indian Journal of Experimental Biology. 49: 817-25. PMID 22126012  0.665
2011 Singhal J, Nagaprashantha L, Vatsyayan R, Awasthi S, Singhal SS. RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. Plos One. 6: e24688. PMID 21931813 DOI: 10.1371/Journal.Pone.0024688  0.738
2011 Nagaprashantha LD, Vatsyayan R, Singhal J, Fast S, Roby R, Awasthi S, Singhal SS. Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Biochemical Pharmacology. 82: 1100-9. PMID 21803027 DOI: 10.1016/J.Bcp.2011.07.078  0.763
2011 Tammali R, Reddy AB, Saxena A, Rychahou PG, Evers BM, Qiu S, Awasthi S, Ramana KV, Srivastava SK. Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis. 32: 1259-67. PMID 21642355 DOI: 10.1093/carcin/bgr102  0.653
2011 Singhal J, Yadav S, Nagaprashantha LD, Vatsyayan R, Singhal SS, Awasthi S. Targeting p53-null neuroblastomas through RLIP76. Cancer Prevention Research (Philadelphia, Pa.). 4: 879-89. PMID 21411502 DOI: 10.1158/1940-6207.Capr-11-0025  0.765
2011 Nagaprashantha LD, Vatsyayan R, Singhal J, Lelsani P, Prokai L, Awasthi S, Singhal SS. 2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma. Carcinogenesis. 32: 568-75. PMID 21304051 DOI: 10.1093/Carcin/Bgr021  0.796
2011 Singhal SS, Wickramarachchi D, Yadav S, Singhal J, Leake K, Vatsyayan R, Chaudhary P, Lelsani P, Suzuki S, Yang S, Awasthi YC, Awasthi S. Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Molecular Cancer Therapeutics. 10: 16-28. PMID 21220488 DOI: 10.1158/1535-7163.Mct-10-0699  0.817
2011 Vatsyayan R, Chaudhary P, Sharma A, Sharma R, Rao Lelsani PC, Awasthi S, Awasthi YC. Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells. Experimental Eye Research. 92: 147-54. PMID 21134369 DOI: 10.1016/J.Exer.2010.11.010  0.65
2011 Nagaprashantha LD, Vatsyayan R, Lelsani PC, Awasthi S, Singhal SS. The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors. International Journal of Cancer. 128: 743-52. PMID 20949625 DOI: 10.1002/Ijc.25725  0.759
2010 Chaudhary P, Sharma R, Sharma A, Vatsyayan R, Yadav S, Singhal SS, Rauniyar N, Prokai L, Awasthi S, Awasthi YC. Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry. 49: 6263-75. PMID 20565132 DOI: 10.1021/Bi100517X  0.808
2010 Sharma R, Sharma A, Chaudhary P, Pearce V, Vatsyayan R, Singh SV, Awasthi S, Awasthi YC. Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry. 49: 3191-202. PMID 20205397 DOI: 10.1021/Bi100104E  0.691
2010 Vatsyayan R, Lelsani PC, Awasthi S, Singhal SS. RLIP76: a versatile transporter and an emerging target for cancer therapy. Biochemical Pharmacology. 79: 1699-705. PMID 20097178 DOI: 10.1016/J.Bcp.2010.01.016  0.792
2010 Awasthi S, Singhal SS, Yadav S, Singhal J, Vatsyayan R, Zajac E, Luchowski R, Borvak J, Gryczynski K, Awasthi YC. A central role of RLIP76 in regulation of glycemic control. Diabetes. 59: 714-25. PMID 20007934 DOI: 10.2337/Db09-0911  0.786
2010 Singhal SS, Sehrawat A, Sahu M, Singhal P, Vatsyayan R, Rao Lelsani PC, Yadav S, Awasthi S. Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. International Journal of Cancer. 126: 1327-38. PMID 19626587 DOI: 10.1002/Ijc.24767  0.782
2010 Dalasanur Nagaprashantha L, Singhal J, Vatsyayan R, Lelsani P, Singhal SS, Prokai L, Awasthi S. Proteomic analysis of drug metabolizing networks in renal cell carcinomas with differential drug sensitivity and VHL expression. Journal of Clinical Oncology. 28: e13137-e13137. DOI: 10.1200/Jco.2010.28.15_Suppl.E13137  0.78
2009 Awasthi YC, Chaudhary P, Vatsyayan R, Sharma A, Awasthi S, Sharma R. Physiological and pharmacological significance of glutathione-conjugate transport. Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 12: 540-51. PMID 20183533 DOI: 10.1080/10937400903358975  0.664
2009 Yadav S, Singhal J, Singhal SS, Awasthi S. hSET1: a novel approach for colon cancer therapy. Biochemical Pharmacology. 77: 1635-41. PMID 19426701 DOI: 10.1016/J.Bcp.2009.02.019  0.754
2009 Vatsyayan R, Chaudhary P, Lelsani PC, Singhal P, Awasthi YC, Awasthi S, Singhal SS. Role of RLIP76 in doxorubicin resistance in lung cancer. International Journal of Oncology. 34: 1505-11. PMID 19424567 DOI: 10.3892/Ijo_00000279  0.798
2009 Singhal SS, Singhal J, Yadav S, Sahu M, Awasthi YC, Awasthi S. RLIP76: a target for kidney cancer therapy. Cancer Research. 69: 4244-51. PMID 19417134 DOI: 10.1158/0008-5472.Can-08-3521  0.822
2009 Singhal SS, Yadav S, Vatsyayan R, Chaudhary P, Borvak J, Singhal J, Awasthi S. Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis. Cancer Letters. 283: 152-8. PMID 19375851 DOI: 10.1016/J.Canlet.2009.03.033  0.784
2009 Singhal SS, Sehrawat A, Mehta A, Sahu M, Awasthi S. Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. International Journal of Oncology. 34: 191-9. PMID 19082490 DOI: 10.3892/Ijo_00000141  0.772
2009 Singhal SS, Roth C, Leake K, Singhal J, Yadav S, Awasthi S. Regression of prostate cancer xenografts by RLIP76 depletion. Biochemical Pharmacology. 77: 1074-83. PMID 19073149 DOI: 10.1016/J.Bcp.2008.11.013  0.784
2008 Sharma A, Sharma R, Chaudhary P, Vatsyayan R, Pearce V, Jeyabal PV, Zimniak P, Awasthi S, Awasthi YC. 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Archives of Biochemistry and Biophysics. 480: 85-94. PMID 18930016 DOI: 10.1016/J.Abb.2008.09.016  0.643
2008 Warnke MM, Wanigasekara E, Singhal SS, Singhal J, Awasthi S, Armstrong DW. The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS. Analytical and Bioanalytical Chemistry. 392: 1325-33. PMID 18815773 DOI: 10.1007/S00216-008-2383-3  0.719
2008 Singhal J, Singhal SS, Yadav S, Suzuki S, Warnke MM, Yacoub A, Dent P, Bae S, Sharma R, Awasthi YC, Armstrong DW, Awasthi S. RLIP76 in defense of radiation poisoning. International Journal of Radiation Oncology, Biology, Physics. 72: 553-61. PMID 18793957 DOI: 10.1016/J.Ijrobp.2008.06.1497  0.799
2008 Singhal SS, Yadav S, Singhal J, Sahu M, Sehrawat A, Awasthi S. Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. Febs Letters. 582: 3408-14. PMID 18789326 DOI: 10.1016/J.Febslet.2008.09.001  0.749
2008 Awasthi S, Singhal SS, Awasthi YC, Martin B, Woo JH, Cunningham CC, Frankel AE. RLIP76 and Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4372-7. PMID 18628450 DOI: 10.1158/1078-0432.Ccr-08-0145  0.812
2008 Singhal SS, Yadav S, Drake K, Singhal J, Awasthi S. Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. The Journal of Biological Chemistry. 283: 19714-29. PMID 18474607 DOI: 10.1074/Jbc.M708703200  0.817
2008 Awasthi YC, Sharma R, Sharma A, Yadav S, Singhal SS, Chaudhary P, Awasthi S. Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radical Biology & Medicine. 45: 111-8. PMID 18456001 DOI: 10.1016/J.Freeradbiomed.2008.04.007  0.799
2008 Sharma R, Sharma A, Dwivedi S, Zimniak P, Awasthi S, Awasthi YC. 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry. 47: 143-56. PMID 18069800 DOI: 10.1021/Bi701559F  0.633
2007 Janigro D, Awasthi S, Awasthi YC, Sharma R, Yadav S, Singhal SS, Hallene K. RLIP76 in AED drug resistance. Epilepsia. 48: 1218-9; author reply. PMID 17553125 DOI: 10.1111/J.1528-1167.2007.01155_4.X  0.77
2007 Awasthi YC, Sharma R, Yadav S, Dwivedi S, Sharma A, Awasthi S. The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance. Current Drug Metabolism. 8: 315-23. PMID 17504221 DOI: 10.2174/138920007780655414  0.699
2007 Singhal SS, Singhal J, Yadav S, Dwivedi S, Boor PJ, Awasthi YC, Awasthi S. Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Research. 67: 4382-9. PMID 17483352 DOI: 10.1158/0008-5472.Can-06-4124  0.835
2007 Singhal SS, Singhal J, Nair MP, Lacko AG, Awasthi YC, Awasthi S. Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. International Journal of Oncology. 30: 717-25. PMID 17273774 DOI: 10.3892/Ijo.30.3.717  0.815
2007 Yadav S, Zajac E, Singhal SS, Awasthi S. Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Reviews. 26: 59-69. PMID 17260165 DOI: 10.1007/S10555-007-9043-5  0.82
2007 Drake KJ, Singhal J, Yadav S, Nadkar A, Pungaliya C, Singhal SS, Awasthi S. RALBP1/RLIP76 mediates multidrug resistance. International Journal of Oncology. 30: 139-44. PMID 17143522 DOI: 10.3892/Ijo.30.1.139  0.802
2006 Tammali R, Ramana KV, Singhal SS, Awasthi S, Srivastava SK. Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Research. 66: 9705-13. PMID 17018629 DOI: 10.1158/0008-5472.Can-06-2105  0.816
2006 Nadkar A, Pungaliya C, Drake K, Zajac E, Singhal SS, Awasthi S. Therapeutic resistance in lung cancer. Expert Opinion On Drug Metabolism & Toxicology. 2: 753-77. PMID 17014393 DOI: 10.1517/17425255.2.5.753  0.799
2006 Li J, Sharma R, Patrick B, Sharma A, Jeyabal PV, Reddy PM, Saini MK, Dwivedi S, Dhanani S, Ansari NH, Zimniak P, Awasthi S, Awasthi YC. Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry. 45: 12253-64. PMID 17014078 DOI: 10.1021/Bi060780+  0.671
2006 Singhal SS, Yadav S, Singhal J, Awasthi YC, Awasthi S. Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76. Biochemical and Biophysical Research Communications. 348: 722-7. PMID 16890208 DOI: 10.1016/J.Bbrc.2006.07.118  0.806
2006 Sharma A, Patrick B, Li J, Sharma R, Jeyabal PV, Reddy PM, Awasthi S, Awasthi YC. Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis. Archives of Biochemistry and Biophysics. 452: 165-73. PMID 16890185 DOI: 10.1016/J.Abb.2006.04.006  0.715
2006 Ramana KV, Bhatnagar A, Srivastava S, Yadav UC, Awasthi S, Awasthi YC, Srivastava SK. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. The Journal of Biological Chemistry. 281: 17652-60. PMID 16648138 DOI: 10.1074/Jbc.M600270200  0.785
2006 Singhal SS, Wickramarachchi D, Singhal J, Yadav S, Awasthi YC, Awasthi S. Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. Febs Letters. 580: 2258-64. PMID 16579994 DOI: 10.1016/J.Febslet.2006.03.038  0.814
2006 Singhal SS, Awasthi YC, Awasthi S. Regression of melanoma in a murine model by RLIP76 depletion. Cancer Research. 66: 2354-60. PMID 16489041 DOI: 10.1158/0008-5472.Can-05-3534  0.827
2005 Awasthi YC, Ansari GA, Awasthi S. Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods in Enzymology. 401: 379-407. PMID 16399399 DOI: 10.1016/S0076-6879(05)01024-4  0.645
2005 Awasthi S, Hallene KL, Fazio V, Singhal SS, Cucullo L, Awasthi YC, Dini G, Janigro D. RLIP76, a non-ABC transporter, and drug resistance in epilepsy. Bmc Neuroscience. 6: 61. PMID 16188027 DOI: 10.1186/1471-2202-6-61  0.799
2005 Singhal SS, Yadav S, Singhal J, Drake K, Awasthi YC, Awasthi S. The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. Febs Letters. 579: 4635-41. PMID 16087181 DOI: 10.1016/J.Febslet.2005.07.032  0.811
2005 Awasthi S, Singhal SS, Yadav S, Singhal J, Drake K, Nadkar A, Zajac E, Wickramarachchi D, Rowe N, Yacoub A, Boor P, Dwivedi S, Dent P, Jarman WE, John B, et al. RLIP76 is a major determinant of radiation sensitivity. Cancer Research. 65: 6022-8. PMID 16024601 DOI: 10.1158/0008-5472.Can-05-0968  0.784
2005 Patrick B, Li J, Jeyabal PV, Reddy PM, Yang Y, Sharma R, Sinha M, Luxon B, Zimniak P, Awasthi S, Awasthi YC. Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. Biochemical and Biophysical Research Communications. 334: 425-32. PMID 16005854 DOI: 10.1016/J.Bbrc.2005.06.099  0.671
2005 Singhal SS, Yadav S, Singhal J, Zajac E, Awasthi YC, Awasthi S. Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochemical Pharmacology. 70: 481-8. PMID 15950949 DOI: 10.1016/J.Bcp.2005.05.005  0.823
2005 Yadav S, Zajac E, Singhal SS, Singhal J, Drake K, Awasthi YC, Awasthi S. POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochemical and Biophysical Research Communications. 328: 1003-9. PMID 15707977 DOI: 10.1016/J.Bbrc.2005.01.055  0.825
2005 Stuckler D, Singhal J, Singhal SS, Yadav S, Awasthi YC, Awasthi S. RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Research. 65: 991-8. PMID 15705900  0.824
2004 Yadav S, Singhal SS, Singhal J, Wickramarachchi D, Knutson E, Albrecht TB, Awasthi YC, Awasthi S. Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses. Biochemistry. 43: 16243-53. PMID 15610018 DOI: 10.1021/Bi0482811  0.791
2004 Sharma R, Singhal SS, Wickramarachchi D, Awasthi YC, Awasthi S. RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. International Journal of Cancer. Journal International Du Cancer. 112: 934-42. PMID 15386349 DOI: 10.1002/Ijc.20516  0.817
2004 Awasthi YC, Yang Y, Tiwari NK, Patrick B, Sharma A, Li J, Awasthi S. Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radical Biology & Medicine. 37: 607-19. PMID 15288119 DOI: 10.1016/J.Freeradbiomed.2004.05.033  0.688
2004 Sharma R, Brown D, Awasthi S, Yang Y, Sharma A, Patrick B, Saini MK, Singh SP, Zimniak P, Singh SV, Awasthi YC. Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. European Journal of Biochemistry / Febs. 271: 1690-701. PMID 15096208 DOI: 10.1111/J.1432-1033.2004.04067.X  0.676
2004 Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi YC. Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxidants & Redox Signaling. 6: 289-300. PMID 15025930 DOI: 10.1089/152308604322899350  0.659
2004 Engle MR, Singh SP, Czernik PJ, Gaddy D, Montague DC, Ceci JD, Yang Y, Awasthi S, Awasthi YC, Zimniak P. Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicology and Applied Pharmacology. 194: 296-308. PMID 14761685 DOI: 10.1016/J.Taap.2003.10.001  0.662
2003 Awasthi YC, Sharma R, Cheng JZ, Yang Y, Sharma A, Singhal SS, Awasthi S. Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Molecular Aspects of Medicine. 24: 219-30. PMID 12893000 DOI: 10.1016/S0098-2997(03)00017-7  0.813
2003 Yang Y, Sharma A, Sharma R, Patrick B, Singhal SS, Zimniak P, Awasthi S, Awasthi YC. Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. The Journal of Biological Chemistry. 278: 41380-8. PMID 12888579 DOI: 10.1074/Jbc.M305766200  0.821
2003 Sharma R, Yang Y, Sharma A, Dwivedi S, Popov VL, Boor PJ, Singhal SS, Awasthi S, Awasthi YC. Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells. Investigative Ophthalmology & Visual Science. 44: 3438-49. PMID 12882793 DOI: 10.1167/Iovs.03-0051  0.819
2003 Awasthi S, Singhal SS, Sharma R, Zimniak P, Awasthi YC. Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. International Journal of Cancer. Journal International Du Cancer. 106: 635-46. PMID 12866021 DOI: 10.1002/Ijc.11260  0.815
2003 Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochimica Polonica. 50: 319-36. PMID 12833161 DOI: 10.18388/Abp.2003_3689  0.688
2003 Sharma R, Awasthi YC, Yang Y, Sharma A, Singhal SS, Awasthi S. Energy dependent transport of xenobiotics and its relevance to multidrug resistance. Current Cancer Drug Targets. 3: 89-107. PMID 12678713 DOI: 10.2174/1568009033482047  0.823
2003 Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. International Journal of Oncology. 22: 721-32. PMID 12632061 DOI: 10.3892/Ijo.22.4.721  0.809
2003 Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. International Journal of Oncology. 22: 713-20. PMID 12632060 DOI: 10.3892/Ijo.22.4.713  0.814
2003 Singhal SS, Singhal J, Sharma R, Singh SV, Zimniak P, Awasthi YC, Awasthi S. Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. International Journal of Oncology. 22: 365-75. PMID 12527936 DOI: 10.3892/Ijo.22.2.365  0.826
2002 Awasthi S, Sharma R, Yang Y, Singhal SS, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC. Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76). Acta Biochimica Polonica. 49: 855-67. PMID 12545192 DOI: 10.18388/Abp.2002_3745  0.822
2002 Awasthi S, Sharma R, Singhal SS, Zimniak P, Awasthi YC. RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1300-10. PMID 12433796 DOI: 10.1124/Dmd.30.12.1300  0.826
2002 Sharma R, Sharma A, Yang Y, Awasthi S, Singhal SS, Zimniak P, Awasthi YC. Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal. Acta Biochimica Polonica. 49: 693-701. PMID 12422239 DOI: 10.18388/Abp.2002_3778  0.805
2002 Yang Y, Sharma R, Cheng JZ, Saini MK, Ansari NH, Andley UP, Awasthi S, Awasthi YC. Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Investigative Ophthalmology & Visual Science. 43: 434-45. PMID 11818388  0.647
2002 Singh SP, Janecki AJ, Srivastava SK, Awasthi S, Awasthi YC, Xia SJ, Zimniak P. Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. The Journal of Biological Chemistry. 277: 4232-9. PMID 11714719 DOI: 10.1074/Jbc.M109678200  0.63
2001 Cheng JZ, Sharma R, Yang Y, Singhal SS, Sharma A, Saini MK, Singh SV, Zimniak P, Awasthi S, Awasthi YC. Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. The Journal of Biological Chemistry. 276: 41213-23. PMID 11522795 DOI: 10.1074/Jbc.M106838200  0.814
2001 Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zimniak P, Awasthi YC. Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling. Archives of Biochemistry and Biophysics. 392: 197-207. PMID 11488593 DOI: 10.1006/Abbi.2001.2452  0.809
2001 Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC. RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Archives of Biochemistry and Biophysics. 391: 171-9. PMID 11437348 DOI: 10.1006/Abbi.2001.2395  0.81
2001 Cheng JZ, Yang Y, Singh SP, Singhal SS, Awasthi S, Pan SS, Singh SV, Zimniak P, Awasthi YC. Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues. Biochemical and Biophysical Research Communications. 282: 1268-74. PMID 11302754 DOI: 10.1006/Bbrc.2001.4707  0.785
2001 Awasthi S, Cheng JZ, Singhal SS, Pandya U, Sharma R, Singh SV, Zimniak P, Awasthi YC. Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences. Biochemistry. 40: 4159-68. PMID 11300797 DOI: 10.1021/Bi002182F  0.792
2001 Yang Y, Cheng JZ, Singhal SS, Saini M, Pandya U, Awasthi S, Awasthi YC. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. The Journal of Biological Chemistry. 276: 19220-30. PMID 11279091 DOI: 10.1074/Jbc.M100551200  0.808
2001 Pandya U, Srivastava SK, Singhal SS, Pal A, Awasthi S, Zimniak P, Awasthi YC, Singh SV. Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil. Biochemical and Biophysical Research Communications. 278: 258-62. PMID 11071881 DOI: 10.1006/Bbrc.2000.3787  0.804
2001 Singhal SS, Singhal J, Cheng J, Pikuła S, Sharma R, Zimniak P, Awasthi YC, Awasthi S. Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes. Acta Biochimica Polonica. 48: 551-562. DOI: 10.18388/Abp.2001_3938  0.811
2000 Sharma R, Awasthi S, Zimniak P, Awasthi YC. Transport of glutathione-conjugates in human erythrocytes Acta Biochimica Polonica. 47: 751-762. PMID 11310974 DOI: 10.18388/Abp.2000_3993  0.7
2000 Awasthi S, Pandya U, Singhal SS, Lin JT, Thiviyanathan V, Seifert WE, Awasthi YC, Ansari GA. Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chemico-Biological Interactions. 128: 19-38. PMID 10996298 DOI: 10.1016/S0009-2797(00)00185-X  0.792
2000 Awasthi S, Cheng J, Singhal SS, Saini MK, Pandya U, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry. 39: 9327-34. PMID 10924126 DOI: 10.1021/Bi992964C  0.822
2000 Pandya U, Saini MK, Jin GF, Awasthi S, Godley BF, Awasthi YC. Dietary curcumin prevents ocular toxicity of naphthalene in rats Toxicology Letters. 115: 195-204. PMID 10814889 DOI: 10.1016/S0378-4274(00)00191-0  0.657
2000 Pandya U, Chandra A, Awasthi S, Jin G, Piper JT, Godley BF, Awasthi YC. Attenuation of galactose cataract by low levels of dietary curcumin Nutrition Research. 20: 515-526. DOI: 10.1016/S0271-5317(00)00143-3  0.624
1999 Cheng JZ, Singhal SS, Saini M, Singhal J, Piper JT, Van Kuijk FJ, Zimniak P, Awasthi YC, Awasthi S. Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells. Archives of Biochemistry and Biophysics. 372: 29-36. PMID 10562413 DOI: 10.1006/Abbi.1999.1479  0.797
1999 Srivastava SK, Hu X, Xia H, Awasthi S, Amin S, Singh SV. Metabolic fate of glutathione conjugate of benzo[a]pyrene-(7R,8S)-diol (9S,10R)-epoxide in human liver. Archives of Biochemistry and Biophysics. 371: 340-4. PMID 10545223 DOI: 10.1006/Abbi.1999.1475  0.355
1999 Singhal SS, Awasthi S, Pandya U, Piper JT, Saini MK, Cheng JZ, Awasthi YC. The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells. Toxicology Letters. 109: 87-95. PMID 10514034 DOI: 10.1016/S0378-4274(99)00124-1  0.814
1999 He N, Singhal SS, Awasthi S, Zhao T, Boor PJ. Role of glutathione S-transferase 8-8 in allylamine resistance of vascular smooth muscle cells in vitro. Toxicology and Applied Pharmacology. 158: 177-85. PMID 10406932 DOI: 10.1006/Taap.1999.8700  0.755
1999 Zhao T, Singhal SS, Piper JT, Cheng J, Pandya U, Clark-Wronski J, Awasthi S, Awasthi YC. The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress. Archives of Biochemistry and Biophysics. 367: 216-24. PMID 10395737 DOI: 10.1006/Abbi.1999.1277  0.797
1999 Awasthi S, Singhal SS, Pandya U, Gopal S, Zimniak P, Singh SV, Awasthi YC. ATP-dependent colchicine transport by human erythrocyte glutathione conjugate transporter Toxicology and Applied Pharmacology. 155: 215-226. PMID 10079207 DOI: 10.1006/Taap.1998.8617  0.808
1998 He NG, Awasthi S, Singhal SS, Trent MB, Boor PJ. The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall. Toxicology and Applied Pharmacology. 152: 83-9. PMID 9772203 DOI: 10.1006/Taap.1998.8511  0.758
1998 Singh SV, Benson PJ, Hu X, Pal A, Xia H, Srivastava SK, Awasthi S, Zaren HA, Orchard JL, Awasthi YC. Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis. Cancer Letters. 128: 197-204. PMID 9683283 DOI: 10.1016/S0304-3835(98)00072-X  0.642
1998 Piper JT, Singhal SS, Salameh MS, Torman RT, Awasthi YC, Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. The International Journal of Biochemistry & Cell Biology. 30: 445-56. PMID 9675878 DOI: 10.1016/S1357-2725(98)00015-6  0.797
1998 Srivastava SK, Hu X, Xia H, Bleicher RJ, Zaren HA, Orchard JL, Awasthi S, Singh SV. ATP-dependent transport of glutathione conjugate of 7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene in murine hepatic canalicular plasma membrane vesicles Biochemical Journal. 332: 799-805. PMID 9620885 DOI: 10.1042/Bj3320799  0.357
1998 Awasthi S, Singhal SS, Pikula S, Piper JT, Srivastava SK, Torman RT, Bandorowicz-Pikula J, Lin JT, Singh SV, Zimniak P, Awasthi YC. ATP-Dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity. Biochemistry. 37: 5239-48. PMID 9548755 DOI: 10.1021/Bi972131R  0.8
1998 Awasthi S, Singhal SS, Srivastava SK, Torman RT, Zimniak P, Bandorowicz-Pikula J, Singh SV, Piper JT, Awasthi YC, Pikula S. ATP-Dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity. Biochemistry. 37: 5231-8. PMID 9548754 DOI: 10.1021/Bi972130Z  0.786
1998 Morrison RJ, Singhal SS, Bidani A, Heming TA, Awasthi S. Glutathione S-transferases of rabbit lung macrophages. Toxicology and Applied Pharmacology. 148: 229-36. PMID 9473530 DOI: 10.1006/Taap.1997.8339  0.755
1997 Awasthi YC, Awasthi S, Zimniak P. Multiple transport proteins involved in the detoxification of endo- and xenobiotics. Frontiers in Bioscience : a Journal and Virtual Library. 2: d427-437. PMID 28481204 DOI: 10.2741/A202  0.685
1997 Hu X, Benson PJ, Srivastava SK, Xia H, Bleicher RJ, Zaren HA, Awasthi S, Awasthi YC, Singh SV. Induction of glutathione S-transferase pi as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model. International Journal of Cancer. Journal International Du Cancer. 73: 897-902. PMID 9399673 DOI: 10.1002/(Sici)1097-0215(19971210)73:6<897::Aid-Ijc23>3.0.Co;2-0  0.666
1997 Hu X, Ji X, Srivastava SK, Xia H, Awasthi S, Nanduri B, Awasthi YC, Zimniak P, Singh SV. Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene. Archives of Biochemistry and Biophysics. 345: 32-8. PMID 9281308 DOI: 10.1006/Abbi.1997.0269  0.764
1997 Sharma R, Haque AK, Awasthi S, Singh SV, Piper JT, Awasthi YC. Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung Journal of Toxicology and Environmental Health. 52: 45-62. PMID 9269322 DOI: 10.1080/00984109708984052  0.621
1997 Awasthi S, Singhal SS, Srivastava SK, Chaubey M, Piper JT, Zimniak P, Yallampalli C, Rajaraman S, Awasthi YC. Rat GST 8-8 is expressed predominantly in myeloid origin cells infiltrating the gravid uterus. The International Journal of Biochemistry & Cell Biology. 29: 807-13. PMID 9251248 DOI: 10.1016/S1357-2725(96)00173-2  0.798
1997 Hu X, O'Donnell R, Srivastava SK, Xia H, Zimniak P, Nanduri B, Bleicher RJ, Awasthi S, Awasthi YC, Ji X, Singh SV. Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene. Biochemical and Biophysical Research Communications. 235: 424-8. PMID 9199210 DOI: 10.1006/Bbrc.1997.6777  0.65
1997 Zimniak L, Awasthi S, Srivastava SK, Zimniak P. Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4-4. Toxicology and Applied Pharmacology. 143: 221-9. PMID 9073611 DOI: 10.1006/Taap.1996.8070  0.667
1997 He NG, Singhal SS, Chaubey M, Awasthi S, Zimniak P, Partridge CA, Awasthi YC. Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells. Biochimica Et Biophysica Acta. 1291: 182-8. PMID 8980630 DOI: 10.1016/S0304-4165(96)00064-5  0.807
1997 Singhal SS, Piper JT, Srivastava SK, Chaubey M, Bandorowicz-Pikula J, Awasthi S, Awasthi YC. Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin. Toxicology and Applied Pharmacology. 140: 378-86. PMID 8887455 DOI: 10.1006/Taap.1996.0234  0.795
1996 Singhal SS, Yallampalli C, Singhal J, Piper JT, Awasthi S. Purification and characterization of glutathione S-transferases of rat uterus International Journal of Biochemistry and Cell Biology. 28: 1271-1283. PMID 9022286 DOI: 10.1016/S1357-2725(96)00060-X  0.745
1996 Srivastava SK, Singhal SS, Awasthi S, Pikula S, Ansari NH, Awasthi YC. A glutathione S-transferases isozyme (bGST 5.8) involved in the metabolism of 4-hydroxy-2-trans-nonenal is localized in bovine lens epithelium Experimental Eye Research. 63: 329-337. PMID 8943706 DOI: 10.1006/Exer.1996.0122  0.787
1996 Awasthi S, Singhal SS, He N, Chaubey M, Zimniak P, Srivastava SK, Singh SV, Awasthi YC. Modulation of doxorubicin cytotoxicity by ethacrynic acid. International Journal of Cancer. 68: 333-9. PMID 8903475 DOI: 10.1002/(Sici)1097-0215(19961104)68:3<333::Aid-Ijc11>3.0.Co;2-9  0.825
1996 Awasthi S, Srivatava SK, Piper JT, Singhal SS, Chaubey M, Awasthi YC. Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses American Journal of Clinical Nutrition. 64: 761-766. PMID 8901798 DOI: 10.1093/Ajcn/64.5.761  0.79
1996 He NG, Singhal SS, Srivastava SK, Zimniak P, Awasthi YC, Awasthi S. Transfection of a 4-hydroxynonenal metabolizing glutathione S- transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells Archives of Biochemistry and Biophysics. 333: 214-220. PMID 8806773 DOI: 10.1006/Abbi.1996.0383  0.801
1996 Srivastava SK, Awasthi S, Wang L, Bhatnagar A, Awasthi YC, Ansari NH. Attenuation of 4-hydroxynonenal-induced cataractogenesis in rat lens by butylated hydroxytoluene Current Eye Research. 15: 749-754. PMID 8670783 DOI: 10.3109/02713689609003458  0.627
1995 Khan MF, Srivastava SK, Singhal SS, Chaubey M, Awasthi S, Petersen DR, Ansari GA, Awasthi YC. Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme. Toxicology and Applied Pharmacology. 131: 63-72. PMID 7878679 DOI: 10.1006/taap.1995.1047  0.779
1995 Gupta V, Jani JP, Jacobs S, Levitt M, Fields L, Awasthi S, Xu BH, Sreevardhan M, Awasthi YC, Singh SV. Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine. Cancer Chemotherapy and Pharmacology. 36: 13-9. PMID 7720170 DOI: 10.1007/Bf00685726  0.679
1995 Misra P, Srivastava SK, Singhal SS, Awasthi S, Awasthi YC, Boor PJ. Glutathione S-Transferase 8-8 Is Localized in Smooth Muscle Cells of Rat Aorta and Is Induced in an Experimental Model of Atherosclerosis Toxicology and Applied Pharmacology. 133: 27-33. PMID 7597707 DOI: 10.1006/Taap.1995.1123  0.789
1994 Sharma R, Singhal SS, Srivastava SK, Bajpai KK, Frenkel EP, Awasthi S. Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines. Cancer Letters. 75: 111-9. PMID 8293421 DOI: 10.1016/0304-3835(93)90195-F  0.815
1994 Singhal SS, Zimniak P, Awasthi S, Piper JT, He NG, Teng JI, Petersen DR, Awasthi YC. Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues. Archives of Biochemistry and Biophysics. 311: 242-50. PMID 8203886 DOI: 10.1006/Abbi.1994.1233  0.794
1994 Singhal SS, Zimniak P, Sharma R, Srivastava SK, Awasthi S, Awasthi YC. A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 1204: 279-286. PMID 8142470 DOI: 10.1016/0167-4838(94)90019-1  0.793
1994 Zimniak P, Nanduri B, Pikuła S, Bandorowicz-Pikuła J, Singhal SS, Srivastava SK, Awasthi S, Awasthi YC. Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. European Journal of Biochemistry. 224: 893-9. PMID 7925413 DOI: 10.1111/J.1432-1033.1994.00893.X  0.789
1994 Awasthi S, Sharma R, Singhal SS, Herzog NK, Chaubey M, Awasthi YC. Modulation of cisplatin cytotoxicity by sulphasalazine British Journal of Cancer. 70: 190-194. PMID 7914420 DOI: 10.1038/Bjc.1994.278  0.804
1994 Awasthi S, Singhal SS, Srivastava SK, Zimniak P, Bajpai KK, Saxena M, Sharma R, Ziller SA, Frenkel EP, Singh SV. Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. The Journal of Clinical Investigation. 93: 958-65. PMID 7907606 DOI: 10.1172/Jci117102  0.808
1994 Awasthi S, Singhal SS, Srivastava SK, Awasthi YC. Doxorubicin, daunorubicin and vinblastine are transported by a glutathione conjugate transporter Anti-Cancer Drugs. 5: 6. DOI: 10.1097/00001813-199409001-00009  0.789
1994 Chaubey M, Singhal SS, Awasthi S, Saxena M, Dyer RB, Awasthi YC, Herzog NK. Gender-related differences in expression of murine glutathione S-transferases and their induction by butylated hydroxyanisole Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 108: 311-319. DOI: 10.1016/0742-8413(94)00025-6  0.775
1993 Singhal SS, Saxena M, Awasthi S, Mukhtar H, Zaidi SI, Ahmad H, Awasthi YC. Glutathione S-transferases of human skin: qualitative and quantitative differences in men and women. Biochimica Et Biophysica Acta. 1163: 266-72. PMID 8507665 DOI: 10.1016/0167-4838(93)90161-J  0.771
1993 Awasthi S, Singhal SS, Srivastava SK, Awasthi YC. Purification and Characterization of Glutathione S-Transferase of Murine Ovary and Testis Archives of Biochemistry and Biophysics. 301: 143-150. PMID 8442656 DOI: 10.1006/Abbi.1993.1126  0.786
1993 Awasthi S, Boor PJ. Semicarbazide protection from in vivo oxidant injury of vascular tissue by allylamine. Toxicology Letters. 66: 157-63. PMID 8430435 DOI: 10.1016/0378-4274(93)90090-K  0.309
1993 Awasthi S, Srivastava SK, Ahmad F, Ahmad H, Ansari GA. Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate. Biochimica Et Biophysica Acta. 1164: 173-8. PMID 8329448 DOI: 10.1016/0167-4838(93)90245-M  0.658
1993 Zimniak P, Awasthi S, Awasthi YC. Phase III detoxification system Trends in Biochemical Sciences. 18: 164-165. PMID 8101022 DOI: 10.1016/0968-0004(93)90106-W  0.58
1993 Awasthi S, Ahmad F, Sharma R, Ahmad H. Reversed-phase chromatographic method for specific determination of glutathione in cultured malignant cells. Journal of Chromatography. 584: 167-73. PMID 1484101 DOI: 10.1016/0378-4347(92)80572-8  0.326
1992 Awasthi S, Sharma R, Awasthi YC, Belli JA, Frenkel EP. The relationship of doxorubicin binding to membrane lipids with drug resistance Cancer Letters. 63: 109-116. PMID 1562987 DOI: 10.1016/0304-3835(92)90060-9  0.708
1992 Singhal SS, Saxena M, Ahmad H, Awasthi S, Haque AK, Awasthi YC. Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the α-class isozymes against lipid peroxidation Archives of Biochemistry and Biophysics. 299: 232-241. PMID 1444461 DOI: 10.1016/0003-9861(92)90269-3  0.782
1992 Singhal SS, Saxena M, Awasthi S, Ahmad H, Sharma R, Awasthi YC. Gender related differences in the expression and characteristics of glutathione S-transferases of human colon Bba - Gene Structure and Expression. 1171: 19-26. PMID 1420361 DOI: 10.1016/0167-4781(92)90135-M  0.769
1992 Saxena M, Singhal SS, Awasthi S, Singh SV, Labelle EF, Zimniak P, Awasthi YC. Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes. Archives of Biochemistry and Biophysics. 298: 231-7. PMID 1388012 DOI: 10.1016/0003-9861(92)90117-F  0.784
1986 Srivastava SK, Ansari NH, Hair GA, Awasthi S, Das B. Activation of human erythrocyte, brain, aorta, muscle, and ocular tissue aldose reductase. Metabolism: Clinical and Experimental. 35: 114-8. PMID 3083202 DOI: 10.1016/0026-0495(86)90199-X  0.632
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