| Year |
Citation |
Score |
| 2023 |
Yu BY, Ngo HH, Choi WJ, Keum YS. Dimethyl Itaconate Inhibits Melanogenesis in B16F10 Cells. Antioxidants (Basel, Switzerland). 12. PMID 36978940 DOI: 10.3390/antiox12030692 |
0.31 |
|
| 2020 |
Kang JS, Nam LB, Yoo OK, Keum YS. Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer. Biochemical Pharmacology. 177: 114002. PMID 32360363 DOI: 10.1016/j.bcp.2020.114002 |
0.353 |
|
| 2018 |
Lee J, Kang JS, Ba Nam L, Yoo OK, Keum YS. Suppression of NRF2/ARE by convallatoxin sensitizes A549 cells to 5-FU-mediated apoptosis. Free Radical Research. 1-141. PMID 29902094 DOI: 10.1080/10715762.2018.1489132 |
0.33 |
|
| 2018 |
Jeong J, Wahyudi LD, Keum YS, Yang H, Kim JH. E-p-Methoxycinnamoyl-α-l-rhamnopyranosyl Ester, a Phenylpropanoid Isolated from Scrophularia buergeriana, Increases Nuclear Factor Erythroid-Derived 2-Related Factor 2 Stability by Inhibiting Ubiquitination in Human Keratinocytes. Molecules (Basel, Switzerland). 23. PMID 29584671 DOI: 10.3390/molecules23040768 |
0.356 |
|
| 2016 |
Kim J, Keum YS. NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer. Oxidative Medicine and Cellular Longevity. 2016: 2746457. PMID 27340506 DOI: 10.1155/2016/2746457 |
0.302 |
|
| 2016 |
Lee MH, Hong SH, Park C, Kim GY, Leem SH, Choi SH, Keum YS, Hyun JW, Kwon TK, Hong SH, Choi YH. Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. Oncology Reports. PMID 27221553 DOI: 10.3892/or.2016.4812 |
0.323 |
|
| 2014 |
Kim S, Lee HG, Park SA, Kundu JK, Keum YS, Cha YN, Na HK, Surh YJ. Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. Plos One. 9: e85984. PMID 24489685 DOI: 10.1371/Journal.Pone.0085984 |
0.346 |
|
| 2013 |
Yun DK, Lee J, Keum YS. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomolecules & Therapeutics. 21: 49-53. PMID 24009858 DOI: 10.4062/biomolther.2012.080 |
0.327 |
|
| 2013 |
Das BN, Kim YW, Keum YS. Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates. Oxidative Medicine and Cellular Longevity. 2013: 839409. PMID 23781297 DOI: 10.1155/2013/839409 |
0.324 |
|
| 2012 |
Keum YS. Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes. Biomolecules & Therapeutics. 20: 144-51. PMID 24116287 DOI: 10.4062/biomolther.2012.20.2.144 |
0.307 |
|
| 2011 |
Keum YS. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. Annals of the New York Academy of Sciences. 1229: 184-9. PMID 21793854 DOI: 10.1111/j.1749-6632.2011.06092.x |
0.326 |
|
| 2009 |
Keum YS, Khor TO, Lin W, Shen G, Kwon KH, Barve A, Li W, Kong AN. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharmaceutical Research. 26: 2324-31. PMID 19669099 DOI: 10.1007/S11095-009-9948-5 |
0.597 |
|
| 2009 |
Prawan A, Saw CL, Khor TO, Keum YS, Yu S, Hu L, Kong AN. Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling. Chemico-Biological Interactions. 179: 202-11. PMID 19159619 DOI: 10.1016/J.Cbi.2008.12.014 |
0.371 |
|
| 2008 |
Barve A, Khor TO, Hao X, Keum YS, Yang CS, Reddy B, Kong AN. Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate. Pharmaceutical Research. 25: 2181-9. PMID 18437538 DOI: 10.1007/S11095-008-9574-7 |
0.4 |
|
| 2008 |
Keum YS, Chang PP, Kwon KH, Yuan X, Li W, Hu L, Kong AN. 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis. 29: 594-9. PMID 17916901 DOI: 10.1093/Carcin/Bgm208 |
0.41 |
|
| 2006 |
Keum YS, Han YH, Liew C, Kim JH, Xu C, Yuan X, Shakarjian MP, Chong S, Kong AN. Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharmaceutical Research. 23: 2586-94. PMID 17048120 DOI: 10.1007/S11095-006-9094-2 |
0.309 |
|
| 2006 |
Nair S, Xu C, Shen G, Hebbar V, Gopalakrishnan A, Hu R, Jain MR, Lin W, Keum YS, Liew C, Chan JY, Kong AN. Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Pharmaceutical Research. 23: 2621-37. PMID 16969697 DOI: 10.1007/S11095-006-9099-X |
0.575 |
|
| 2006 |
Keum YS, Yu S, Chang PP, Yuan X, Kim JH, Xu C, Han J, Agarwal A, Kong AN. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. Cancer Research. 66: 8804-13. PMID 16951197 DOI: 10.1158/0008-5472.Can-05-3513 |
0.443 |
|
| 2006 |
Yuan X, Xu C, Pan Z, Keum YS, Kim JH, Shen G, Yu S, Oo KT, Ma J, Kong AN. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Molecular Carcinogenesis. 45: 841-50. PMID 16739127 DOI: 10.1002/Mc.20234 |
0.628 |
|
| 2006 |
Khor TO, Keum YS, Lin W, Kim JH, Hu R, Shen G, Xu C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Research. 66: 613-21. PMID 16423986 DOI: 10.1158/0008-5472.Can-05-2708 |
0.601 |
|
| 2006 |
Kim JH, Xu C, Keum YS, Reddy B, Conney A, Kong AN. Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin. Carcinogenesis. 27: 475-82. PMID 16299382 DOI: 10.1093/Carcin/Bgi272 |
0.48 |
|
| 2006 |
Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis. 27: 437-45. PMID 16272172 DOI: 10.1093/Carcin/Bgi251 |
0.622 |
|
| 2005 |
Keum YS, Jeong WS, Kong AN. Chemopreventive functions of isothiocyanates. Drug News & Perspectives. 18: 445-51. PMID 16362084 DOI: 10.1358/Dnp.2005.18.7.939350 |
0.38 |
|
| 2005 |
Jeong WS, Keum YS, Chen C, Jain MR, Shen G, Kim JH, Li W, Kong AN. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. Journal of Biochemistry and Molecular Biology. 38: 167-76. PMID 15826493 DOI: 10.5483/Bmbrep.2005.38.2.167 |
0.565 |
|
| 2004 |
Keum YS, Jeong WS, Kong AN. Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms. Mutation Research. 555: 191-202. PMID 15476860 DOI: 10.1016/J.Mrfmmm.2004.05.024 |
0.46 |
|
| 2004 |
Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, Kong AN. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. The Journal of Biological Chemistry. 279: 23052-60. PMID 15020583 DOI: 10.1074/Jbc.M401368200 |
0.61 |
|
| 2003 |
Kim BR, Hu R, Keum YS, Hebbar V, Shen G, Nair SS, Kong AN. Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Research. 63: 7520-5. PMID 14612554 |
0.558 |
|
| 2003 |
Keum YS, Owuor ED, Kim BR, Hu R, Kong AN. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharmaceutical Research. 20: 1351-6. PMID 14567627 DOI: 10.1023/A:1025737622815 |
0.365 |
|
| 2003 |
Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 24: 1515-24. PMID 12844482 DOI: 10.1093/carcin/bgg107 |
0.328 |
|
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