Paul Spearman - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Microbiology Biology, Cell Biology

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Beavis AC, Dienger-Stambaugh K, Briggs K, Chen Z, Abraham M, Spearman P, He B. A J Paramyxovirus-vectored HIV vaccine induces humoral and cellular responses in mice. Vaccine. PMID 38443277 DOI: 10.1016/j.vaccine.2024.02.068  0.468
2023 Lerner G, Ding L, Candor K, Spearman P. Incorporation of the HIV-1 envelope glycoprotein into viral particles is regulated by the tubular recycling endosome in a cell type-specific manner. Biorxiv : the Preprint Server For Biology. PMID 38168173 DOI: 10.1101/2023.12.17.572063  0.468
2023 Lerner G, Ding L, Spearman P. Tryptophan-based motifs in the LLP3 region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation. Journal of Virology. 97: e0063123. PMID 37796124 DOI: 10.1128/jvi.00631-23  0.427
2023 Weaver N, Hammonds J, Ding L, Lerner G, Dienger-Stambaugh K, Spearman P. KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein. Journal of Virology. e0025523. PMID 37358446 DOI: 10.1128/jvi.00255-23  0.808
2023 Lerner G, Ding L, Spearman P. Tryptophan-based motifs in the LLP3 Region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation. Biorxiv : the Preprint Server For Biology. PMID 37162911 DOI: 10.1101/2023.04.28.538708  0.442
2023 Thomas SV, Dienger-Stambaugh K, Jordan M, Wang Y, Hammonds J, Spearman P, Shi D. Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species. Bioengineering (Basel, Switzerland). 10. PMID 36978671 DOI: 10.3390/bioengineering10030280  0.687
2022 Anokhin B, Spearman P. Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation. Viruses. 14. PMID 36016351 DOI: 10.3390/v14081729  0.485
2022 Lerner G, Weaver N, Anokhin B, Spearman P. Advances in HIV-1 Assembly. Viruses. 14. PMID 35336885 DOI: 10.3390/v14030478  0.451
2021 Seaton KE, Deal A, Han X, Li SS, Clayton A, Heptinstall J, Duerr A, Allen MA, Shen X, Sawant S, Yates NL, Spearman P, Churchyard G, Goepfert PA, Maenza J, et al. Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans. Npj Vaccines. 6: 56. PMID 33859204 DOI: 10.1038/s41541-021-00305-8  0.37
2021 Xiao P, Dienger-Stambaugh K, Chen X, Wei H, Phan S, Beavis AC, Singh K, Adhikary NRD, Tiwari P, Villinger F, He B, Spearman P. Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates. Frontiers in Immunology. 12: 623996. PMID 33717130 DOI: 10.3389/fimmu.2021.623996  0.42
2020 Rai MA, Hammonds J, Pujato M, Mayhew C, Roskin K, Spearman P. Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Retrovirology. 17: 35. PMID 33213476 DOI: 10.1186/s12977-020-00544-y  0.776
2020 Fan X, Murray SC, Staitieh BS, Spearman P, Guidot DM. HIV Impairs Alveolar Macrophage Function via MicroRNA-144-Induced Suppression of Nrf2. The American Journal of the Medical Sciences. PMID 32773107 DOI: 10.1016/J.Amjms.2020.07.026  0.481
2020 Roskin K, Spearman P. HIV-1 Broadly Neutralizing Antibodies Take the Road Less Traveled, and That Makes All the Difference. Cell Host & Microbe. 27: 487-488. PMID 32272069 DOI: 10.1016/J.Chom.2020.03.017  0.505
2020 Singh K, Marasini B, Chen X, Ding L, Wang JJ, Xiao P, Villinger F, Spearman P. A bivalent, spherical virus-like particle vaccine enhances breadth of immune responses against pathogenic Ebola viruses in rhesus macaques. Journal of Virology. PMID 32075939 DOI: 10.1128/Jvi.01884-19  0.337
2019 Buffone C, Kutzner J, Opp S, Martinez-Lopez A, Selyutina A, Coggings SA, Studdard LR, Ding L, Kim B, Spearman P, Schaller T, Diaz-Griffero F. The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB. Virology. 531: 260-268. PMID 30959264 DOI: 10.1016/J.Virol.2019.03.018  0.53
2019 Spearman P, Tomaras GD, Montefiori DC, Huang Y, Elizaga ML, Ferrari G, Alam SM, Isaacs A, Ahmed H, Hural J, McElrath MJ, Ouedraogo L, Pensiero M, Butler C, Kalams SA, et al. Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest. The Journal of Infectious Diseases. PMID 30615119 DOI: 10.1093/Infdis/Jiz008  0.5
2019 Rai MA, Hammonds JE, Spearman P, Spearman P. 2518. Development And Characterization Of Human Microglial Models To Elucidate HIV Transmission Events And Pathogenesis Open Forum Infectious Diseases. 6: S874-S875. DOI: 10.1093/Ofid/Ofz360.2196  0.791
2018 Rampoldi A, Crooke SN, Preininger MK, Jha R, Maxwell J, Ding L, Spearman P, Finn MG, Xu C. Targeted Elimination of Tumorigenic Human Pluripotent Stem Cells Using Suicide-inducing Virus-like Particles. Acs Chemical Biology. PMID 29979576 DOI: 10.1021/Acschembio.8B00490  0.395
2018 Singh K, Marasini B, Chen X, Spearman P. A novel Ebola virus antibody-dependent cell-mediated cytotoxicity (Ebola ADCC) assay. Journal of Immunological Methods. PMID 29894746 DOI: 10.1016/J.Jim.2018.06.002  0.334
2017 Kirschman J, Qi M, Ding L, Hammonds J, Dienger-Stambaugh K, Wang JJ, Lapierre LA, Goldenring JR, Spearman P. HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment is Required for Particle Incorporation. Journal of Virology. PMID 29212940 DOI: 10.1128/Jvi.01893-17  0.815
2017 Spearman P. Viral Interactions with Host Cell Rab GTPases. Small Gtpases. 0. PMID 28696820 DOI: 10.1080/21541248.2017.1346552  0.449
2017 Staitieh BS, Ding L, Neveu WA, Spearman P, Guidot DM, Fan X. HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages. Journal of Leukocyte Biology. PMID 28550120 DOI: 10.1189/Jlb.4A0616-282Rr  0.529
2017 Yuan Z, Fan X, Staitieh B, Bedi C, Spearman P, Guidot DM, Sadikot RT. HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1. Scientific Reports. 7: 42028. PMID 28181540 DOI: 10.1038/Srep42028  0.519
2017 Hammonds JE, Beeman N, Ding L, Takushi S, Francis AC, Wang JJ, Melikyan GB, Spearman P. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1. Plos Pathogens. 13: e1006181. PMID 28129379 DOI: 10.1371/Journal.Ppat.1006181  0.805
2017 Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER. Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells. Nature Protocols. 12: 150-167. PMID 27977021 DOI: 10.1038/Nprot.2016.168  0.703
2016 Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira EL, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, ... ... Spearman P, et al. Adjuvanting an SIV vaccine with TLR ligands encapsulated in nanoparticles induces persistent antibody responses and enhanced protection in TRIM5α restrictive macaques. Journal of Virology. PMID 27928002 DOI: 10.1128/Jvi.01844-16  0.319
2016 St Gelais C, Kim SH, Ding L, Yount J, Ivanov D, Spearman P, Wu L. A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization and Stability. The Journal of Biological Chemistry. PMID 27815502 DOI: 10.1074/Jbc.M116.753947  0.309
2016 Iyer SS, Gangadhara S, Victor B, Shen X, Chen X, Nabi R, Kasturi SP, Sabula MJ, Labranche CC, Reddy PJ, Tomaras GD, Montefiori DC, Moss B, Spearman P, Pulendran B, et al. Virus-like particles displaying trimeric SIV envelope gp160 enhance the breadth of DNA/MVA SIV vaccine induced antibody responses in rhesus macaques. Journal of Virology. PMID 27466414 DOI: 10.1128/Jvi.01163-16  0.425
2016 Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE. Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein. Plos One. 11: e0158861. PMID 27411063 DOI: 10.1371/Journal.Pone.0158861  0.49
2016 Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, et al. EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression. Plos Pathogens. 12: e1005622. PMID 27152417 DOI: 10.1371/Journal.Ppat.1005622  0.693
2016 Spearman P. HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors. Current Topics in Medicinal Chemistry. 16: 1154-66. PMID 26329615  0.339
2015 Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE. Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations. Molecular Immunology. 70: 94-103. PMID 26748387 DOI: 10.1016/J.Molimm.2015.12.002  0.472
2015 Williams KL, Cortez V, Dingens AS, Gach JS, Rainwater S, Weis JF, Chen X, Spearman P, Forthal DN, Overbaugh J. HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and are Commonly Detected in Plasma from HIV-infected Humans. Ebiomedicine. 2: 1464-1477. PMID 26629541 DOI: 10.1016/J.Ebiom.2015.09.001  0.504
2015 Strauss JD, Hammonds JE, Yi H, Ding L, Spearman P, Wright ER. Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells. Journal of Virology. PMID 26582000 DOI: 10.1128/Jvi.01880-15  0.814
2015 Chukwuma VU, Hicar MD, Chen X, Nicholas KJ, Joyner A, Kalams SA, Landucci G, Forthal DN, Spearman PW, Crowe JE. Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein. Plos One. 10: e0133509. PMID 26226263 DOI: 10.1371/Journal.Pone.0133509  0.37
2015 Giroud C, Marin M, Hammonds J, Spearman P, Melikyan GB. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. Journal of Virology. 89: 9368-82. PMID 26136569 DOI: 10.1128/Jvi.01178-15  0.792
2015 Yi H, Strauss JD, Ke Z, Alonas E, Dillard RS, Hampton CM, Lamb KM, Hammonds JE, Santangelo PJ, Spearman PW, Wright ER. Native Immunogold Labeling of Cell Surface Proteins and Viral Glycoproteins for Cryo-Electron Microscopy and Cryo-Electron Tomography Applications. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26069287 DOI: 10.1369/0022155415593323  0.726
2015 Qi M, Chu H, Chen X, Choi J, Wen X, Hammonds J, Ding L, Hunter E, Spearman P. A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions. Proceedings of the National Academy of Sciences of the United States of America. 112: 7575-80. PMID 26034275 DOI: 10.1073/Pnas.1504174112  0.807
2015 Johnson EL, Chu H, Byrareddy SN, Spearman P, Chakraborty R. Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies. Journal of the International Aids Society. 18: 19385. PMID 25623930 DOI: 10.7448/Ias.18.1.19385  0.546
2015 Williams KL, Cortez V, Dingens AS, Gach JS, Rainwater S, Weis JF, Chen X, Spearman P, Forthal DN, Overbaugh J. HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and are Commonly Detected in Plasma from HIV-infected Humans Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.001  0.396
2014 Wen X, Ding L, Hunter E, Spearman P. An siRNA screen of membrane trafficking genes highlights pathways common to HIV-1 and M-PMV virus assembly and release. Plos One. 9: e106151. PMID 25187981 DOI: 10.1371/Journal.Pone.0106151  0.466
2014 Wen X, Ding L, Wang JJ, Qi M, Hammonds J, Chu H, Chen X, Hunter E, Spearman P. ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events. Journal of Virology. 88: 6906-21. PMID 24696479 DOI: 10.1128/Jvi.00023-14  0.787
2014 Pereira LE, Clark J, Grznarova P, Wen X, LaCasse R, Ruml T, Spearman P, Hunter E. Direct evidence for intracellular anterograde co-transport of M-PMV Gag and Env on microtubules. Virology. 449: 109-19. PMID 24418544 DOI: 10.1016/J.Virol.2013.11.006  0.392
2014 Johnson EL, Chu H, Byrareddy SN, Spearman P, Chakraborty R. Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies Bmc Infectious Diseases. 14. DOI: 10.1186/1471-2334-14-S3-O5  0.542
2014 Strauss JD, Hammonds JE, Spearman PW, Wright ER. Structural characterization of tethered HIV-1 VLPs by light microscopy and cryo-electron tomography Microscopy and Microanalysis. 20: 1256-1257. DOI: 10.1017/S1431927614008010  0.751
2014 Yi H, Strauss JD, Hammonds JE, Dyavar Shetty R, Amara RR, Spearman PW, Wright ER. Immunogold labeling of cultured cells and virus particles for electron microscopy and cryo-electron microscopy applications Microscopy and Microanalysis. 20: 1220-1221. DOI: 10.1017/S1431927614007831  0.714
2013 Clark J, Grznarova P, Stansell E, Diehl W, Lipov J, Spearman P, Ruml T, Hunter E. A Mason-Pfizer Monkey virus Gag-GFP fusion vector allows visualization of capsid transport in live cells and demonstrates a role for microtubules. Plos One. 8: e83863. PMID 24386297 DOI: 10.1371/Journal.Pone.0083863  0.367
2013 Qi M, Williams JA, Chu H, Chen X, Wang JJ, Ding L, Akhirome E, Wen X, Lapierre LA, Goldenring JR, Spearman P. Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex. Plos Pathogens. 9: e1003278. PMID 23592992 DOI: 10.1371/Journal.Ppat.1003278  0.601
2012 Wright ER, Spearman PW. Unraveling the structural basis of HIV-1 neutralization. Future Microbiology. 7: 1251-4. PMID 23075444 DOI: 10.2217/Fmb.12.104  0.375
2012 Chu H, Wang JJ, Qi M, Yoon JJ, Chen X, Wen X, Hammonds J, Ding L, Spearman P. Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages. Cell Host & Microbe. 12: 360-72. PMID 22980332 DOI: 10.1016/J.Chom.2012.07.011  0.825
2012 Liu L, Sutton J, Woodruff E, Villalta F, Spearman P, Dong X. Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. Journal of Virology. 86: 11242-53. PMID 22875976 DOI: 10.1128/Jvi.00544-12  0.547
2012 Hammonds J, Wang JJ, Spearman P. Restriction of Retroviral Replication by Tetherin/BST-2. Molecular Biology International. 2012: 424768. PMID 22811908 DOI: 10.1155/2012/424768  0.788
2012 Li L, Wang XH, Banerjee S, Volsky B, Williams C, Virland D, Nadas A, Seaman MS, Chen X, Spearman P, Zolla-Pazner S, Gorny MK. Different pattern of immunoglobulin gene usage by HIV-1 compared to non-HIV-1 antibodies derived from the same infected subject. Plos One. 7: e39534. PMID 22761815 DOI: 10.1371/Journal.Pone.0039534  0.526
2012 Kyere SK, Mercredi PY, Dong X, Spearman P, Summers MF. The HIV-1 matrix protein does not interact directly with the protein interactive domain of AP-3δ. Virus Research. 169: 411-4. PMID 22705971 DOI: 10.1016/J.Virusres.2012.06.007  0.508
2012 Chu H, Wang JJ, Qi M, Yoon JJ, Wen X, Chen X, Ding L, Spearman P. The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules. Plos One. 7: e35297. PMID 22567100 DOI: 10.1371/Journal.Pone.0035297  0.439
2012 Hammonds J, Ding L, Chu H, Geller K, Robbins A, Wang JJ, Yi H, Spearman P. The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release. Journal of Virology. 86: 2259-72. PMID 22130541 DOI: 10.1128/Jvi.05906-11  0.766
2012 Spearman P, Tomaras G, Montefiori D, Huang Y, Ahmed H, Elizaga M, Hural J, McElrath J, Ouedraogo L, Pensiero M, Butler C, Kalams S, Overton ET, Barnett S. Rapid development of cross-clade neutralizing antibody responses after clade B gp120/gp140 protein priming and clade c gp140 protein boosting Retrovirology. 9: 137. DOI: 10.1186/1742-4690-9-S2-P137  0.306
2011 Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X. Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. The Journal of Biological Chemistry. 286: 28498-510. PMID 21705339 DOI: 10.1074/Jbc.M111.239053  0.61
2011 Coleman CM, Spearman P, Wu L. Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef. Retrovirology. 8: 26. PMID 21504576 DOI: 10.1186/1742-4690-8-26  0.526
2011 Spearman P, Lally MA, Elizaga M, Montefiori D, Tomaras GD, McElrath MJ, Hural J, De Rosa SC, Sato A, Huang Y, Frey SE, Sato P, Donnelly J, Barnett S, Corey LJ, et al. A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers. The Journal of Infectious Diseases. 203: 1165-73. PMID 21451004 DOI: 10.1093/Infdis/Jiq175  0.474
2011 Dang Y, Abudu A, Son S, Harjes E, Spearman P, Matsuo H, Zheng YH. Identification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity. Journal of Virology. 85: 5691-5. PMID 21430060 DOI: 10.1128/Jvi.00243-11  0.392
2010 Hicar MD, Chen X, Briney B, Hammonds J, Wang JJ, Kalams S, Spearman PW, Crowe JE. Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV. Journal of Acquired Immune Deficiency Syndromes (1999). 54: 223-35. PMID 20531016 DOI: 10.1097/Qai.0B013E3181Dc98A3  0.757
2010 Hicar MD, Kalams SA, Spearman PW, Crowe JE. Emerging studies of human HIV-specific antibody repertoires. Vaccine. 28: B18-23. PMID 20510738 DOI: 10.1016/J.Vaccine.2010.02.002  0.405
2010 Hammonds J, Spearman P. An imperfect rule for the particle roost. Cell Host & Microbe. 7: 261-3. PMID 20413094 DOI: 10.1016/J.Chom.2010.04.001  0.782
2010 Hammonds J, Wang JJ, Yi H, Spearman P. Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane. Plos Pathogens. 6: e1000749. PMID 20140192 DOI: 10.1371/Journal.Ppat.1000749  0.816
2010 Varthakavi V, Heimann-Nichols E, Smith RM, Sun Y, Bram RJ, Ali S, Rose J, Ding L, Spearman P. Erratum: Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu (Nature Medicine (2008) 14 (641-647)) Nature Medicine. 16. PMID 20134478 DOI: 10.1038/Nm0210-238  0.42
2010 Ali MS, Hammonds J, Ding L, Spearman P. CAML does not modulate tetherin-mediated restriction of HIV-1 particle release. Plos One. 5: e9005. PMID 20126395 DOI: 10.1371/Journal.Pone.0009005  0.782
2009 Chu H, Wang JJ, Spearman P. Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways. Current Topics in Microbiology and Immunology. 339: 67-84. PMID 20012524 DOI: 10.1007/978-3-642-02175-6_4  0.514
2009 Hammonds J, Spearman P. Tetherin is as tetherin does. Cell. 139: 456-7. PMID 19879831 DOI: 10.1016/J.Cell.2009.10.011  0.789
2009 Dou J, Wang JJ, Chen X, Li H, Ding L, Spearman P. Characterization of a myristoylated, monomeric HIV Gag protein. Virology. 387: 341-52. PMID 19285328 DOI: 10.1016/J.Virol.2009.02.037  0.51
2009 Spearman P, Kalams S, Elizaga M, Metch B, Chiu YL, Allen M, Weinhold KJ, Ferrari G, Parker SD, McElrath MJ, Frey SE, Fuchs JD, Keefer MC, Lubeck MD, Egan M, et al. Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial. Vaccine. 27: 243-9. PMID 18996425 DOI: 10.1016/J.Vaccine.2008.10.051  0.427
2008 Derdowski A, Peters TR, Glover N, Qian R, Utley TJ, Burnett A, Williams JV, Spearman P, Crowe JE. Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. The Journal of General Virology. 89: 2698-708. PMID 18931065 DOI: 10.1099/Vir.0.2008/004051-0  0.762
2008 Varthakavi V, Heimann-Nichols E, Smith RM, Sun Y, Bram RJ, Ali S, Rose J, Ding L, Spearman P. Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu. Nature Medicine. 14: 641-7. PMID 18500349 DOI: 10.1038/Nm1778  0.553
2008 Wang T, Zhang W, Tian C, Liu B, Yu Y, Ding L, Spearman P, Yu XF. Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C. Virology. 377: 71-9. PMID 18495196 DOI: 10.1016/J.Virol.2008.04.012  0.534
2008 Sharma D, Spearman P. The impact of cesarean delivery on transmission of infectious agents to the neonate. Clinics in Perinatology. 35: 407-20, vii-viii. PMID 18456077 DOI: 10.1016/J.Clp.2008.03.010  0.309
2007 Hammonds J, Chen X, Zhang X, Lee F, Spearman P. Advances in methods for the production, purification, and characterization of HIV-1 Gag-Env pseudovirion vaccines. Vaccine. 25: 8036-48. PMID 17936444 DOI: 10.1016/J.Vaccine.2007.09.016  0.787
2007 Li H, Dou J, Ding L, Spearman P. Myristoylation is required for human immunodeficiency virus type 1 Gag-Gag multimerization in mammalian cells. Journal of Virology. 81: 12899-910. PMID 17881447 DOI: 10.1128/Jvi.01280-07  0.41
2007 Zhang X, Cassis-Ghavami F, Eller M, Currier J, Slike BM, Chen X, Tartaglia J, Marovich M, Spearman P. Direct comparison of antigen production and induction of apoptosis by canarypox virus- and modified vaccinia virus ankara-human immunodeficiency virus vaccine vectors. Journal of Virology. 81: 7022-33. PMID 17409140 DOI: 10.1128/Jvi.02654-06  0.405
2007 Burnett A, Spearman P. APOBEC3G multimers are recruited to the plasma membrane for packaging into human immunodeficiency virus type 1 virus-like particles in an RNA-dependent process requiring the NC basic linker. Journal of Virology. 81: 5000-13. PMID 17344295 DOI: 10.1128/Jvi.02237-06  0.475
2007 Goepfert PA, Tomaras GD, Horton H, Montefiori D, Ferrari G, Deers M, Voss G, Koutsoukos M, Pedneault L, Vandepapeliere P, McElrath MJ, Spearman P, Fuchs JD, Koblin BA, Blattner WA, et al. Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers. Vaccine. 25: 510-8. PMID 17049679 DOI: 10.1016/J.Vaccine.2006.07.050  0.453
2007 Spearman P. HIV-1 assembly and cellular trafficking pathways: current understanding and potential for future therapeutics Future Hiv Therapy. 1: 113-122. DOI: 10.2217/17469600.1.1.113  0.506
2006 Spearman P. Cellular cofactors involved in HIV assembly and budding. Current Opinion in Hiv and Aids. 1: 200-7. PMID 19372809 DOI: 10.1097/01.Coh.0000221592.49412.1F  0.486
2006 Spearman P. Current progress in the development of HIV vaccines. Current Pharmaceutical Design. 12: 1147-67. PMID 16515492 DOI: 10.2174/138161206776055859  0.483
2006 Varthakavi V, Smith RM, Martin KL, Derdowski A, Lapierre LA, Goldenring JR, Spearman P. The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release. Traffic (Copenhagen, Denmark). 7: 298-307. PMID 16497224 DOI: 10.1111/J.1600-0854.2005.00380.X  0.823
2005 Hammonds J, Chen X, Fouts T, DeVico A, Montefiori D, Spearman P. Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunization. Journal of Virology. 79: 14804-14. PMID 16282480 DOI: 10.1128/Jvi.79.23.14804-14814.2005  0.773
2005 Batonick M, Favre M, Boge M, Spearman P, Höning S, Thali M. Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. Virology. 342: 190-200. PMID 16139856 DOI: 10.1016/J.Virol.2005.08.001  0.547
2005 Goepfert PA, Horton H, McElrath MJ, Gurunathan S, Ferrari G, Tomaras GD, Montefiori DC, Allen M, Chiu YL, Spearman P, Fuchs JD, Koblin BA, Blattner WA, Frey S, Keefer MC, et al. High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects. The Journal of Infectious Diseases. 192: 1249-59. PMID 16136469 DOI: 10.1086/432915  0.447
2005 Chen X, Rock MT, Hammonds J, Tartaglia J, Shintani A, Currier J, Slike B, Crowe JE, Marovich M, Spearman P. Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses. Journal of Virology. 79: 5537-47. PMID 15827168 DOI: 10.1128/Jvi.79.9.5537-5547.2005  0.806
2005 Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P. AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell. 120: 663-74. PMID 15766529 DOI: 10.1016/J.Cell.2004.12.023  0.828
2004 Wright PF, Mestecky J, McElrath MJ, Keefer MC, Gorse GJ, Goepfert PA, Moldoveanu Z, Schwartz D, Spearman PW, El Habib R, Spring MD, Zhu Y, Smith C, Flores J, Weinhold KJ, et al. Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. The Journal of Infectious Diseases. 189: 1221-31. PMID 15031791 DOI: 10.1086/382088  0.374
2004 Derdowski A, Ding L, Spearman P. A novel fluorescence resonance energy transfer assay demonstrates that the human immunodeficiency virus type 1 Pr55Gag I domain mediates Gag-Gag interactions. Journal of Virology. 78: 1230-42. PMID 14722278 DOI: 10.1128/Jvi.78.3.1230-1242.2004  0.798
2003 Spearman P. HIV vaccine development: lessons from the past and promise for the future. Current Hiv Research. 1: 101-20. PMID 15043215 DOI: 10.2174/1570162033352093  0.456
2003 Varthakavi V, Smith RM, Bour SP, Strebel K, Spearman P. Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production. Proceedings of the National Academy of Sciences of the United States of America. 100: 15154-9. PMID 14657387 DOI: 10.1073/Pnas.2433165100  0.533
2003 Haas DW, Johnson BW, Spearman P, Raffanti S, Nicotera J, Schmidt D, Hulgan T, Shepard R, Fiscus SA. Two phases of HIV RNA decay in CSF during initial days of multidrug therapy. Neurology. 61: 1391-6. PMID 14638961 DOI: 10.1212/Wnl.61.10.1391  0.462
2003 Nydegger S, Foti M, Derdowski A, Spearman P, Thali M. HIV-1 egress is gated through late endosomal membranes. Traffic (Copenhagen, Denmark). 4: 902-10. PMID 14617353 DOI: 10.1046/J.1600-0854.2003.00145.X  0.836
2003 Hammonds J, Chen X, Ding L, Fouts T, De Vico A, zur Megede J, Barnett S, Spearman P. Gp120 stability on HIV-1 virions and Gag-Env pseudovirions is enhanced by an uncleaved Gag core. Virology. 314: 636-49. PMID 14554091 DOI: 10.1016/S0042-6822(03)00467-7  0.799
2003 Ding L, Derdowski A, Wang JJ, Spearman P. Independent segregation of human immunodeficiency virus type 1 Gag protein complexes and lipid rafts. Journal of Virology. 77: 1916-26. PMID 12525626 DOI: 10.1128/Jvi.77.3.1916-1926.2003  0.791
2002 Varthakavi V, Smith RM, Deng H, Sun R, Spearman P. Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta. Virology. 297: 270-80. PMID 12083825 DOI: 10.1006/Viro.2002.1434  0.527
2002 Chen CH, Spearman P. Prospects for AIDS vaccines Trends in Molecular Medicine. 8: 591. DOI: 10.1016/S1471-4914(02)02438-3  0.374
2001 Fang ZY, Limbach K, Tartaglia J, Hammonds J, Chen X, Spearman P. Expression of vaccinia E3L and K3L genes by a novel recombinant canarypox HIV vaccine vector enhances HIV-1 pseudovirion production and inhibits apoptosis in human cells Virology. 291: 272-284. PMID 11878896 DOI: 10.1006/Viro.2001.1209  0.798
2001 Wang JJ, Sandefur S, Spearman P, Chiou CT, Chiang PH, Ratner L. Tracking the assembly pathway of human immunodeficiency virus type 1 Gag deletion mutants by immunogold labeling. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 9: 371-9. PMID 11759066 DOI: 10.1097/00129039-200112000-00014  0.547
2001 Kaslow RA, Rivers C, Tang J, Bender TJ, Goepfert PA, El Habib R, Weinhold K, Mulligan MJ, Clements-Mann ML, Schwartz D, Belshe R, Gorse G, Frey S, Dolin R, Keefer M, ... ... Spearman P, et al. Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines Journal of Virology. 75: 8681-8689. PMID 11507213 DOI: 10.1128/Jvi.75.18.8681-8689.2001  0.388
2001 Spearman P, Fiscus SA, Smith RM, Shepard R, Johnson B, Nicotera J, Harris VL, Clough LA, Haas J, McKinsey DW. Comparison of Roche MONITOR and Organon Teknika NucliSens assays to quantify human immunodeficiency virus type 1 RNA in cerebrospinal fluid Journal of Clinical Microbiology. 39: 1612-1614. PMID 11283098 DOI: 10.1128/Jcm.39.4.1612-1614.2001  0.391
2001 Corey L, Mulligan M, Goepfert P, Sabbaj S, Clements-Mann ML, Harrow C, Schwartz D, Dolin R, Evans T, Keefer M, Belshe R, Gorse G, Frey S, McElrath J, Graham B, ... ... Spearman P, et al. Cellular and humoral immune responses to a canarypox vaccine containing human immunodeficiency virus type 1 env, gag, and pro in combination with RGP120 Journal of Infectious Diseases. 183: 563-570. PMID 11170981 DOI: 10.1086/318523  0.358
2000 Tang YW, Huong JTJ, Lloyd R.M. J, Spearman P, Haas DW. Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma Journal of Clinical Microbiology. 38: 4637-4639. PMID 11101610 DOI: 10.1128/Jcm.38.12.4637-4639.2000  0.43
2000 Haas DW, Clough LA, Johnson BW, Harris VL, Spearman P, Wilkinson GR, Fletcher CV, Fiscus S, Raffanti S, Donlon R, McKinsey J, Nicotera J, Schmidt D, Shoup RE, Kates RE, et al. Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma. Aids Research and Human Retroviruses. 16: 1491-502. PMID 11054262 DOI: 10.1089/088922200750006010  0.438
2000 Sandefur S, Smith RM, Varthakavi V, Spearman P. Mapping and characterization of the N-terminal I domain of human immunodeficiency virus type 1 Pr55(Gag) Journal of Virology. 74: 7238-7249. PMID 10906178 DOI: 10.1128/Jvi.74.16.7238-7249.2000  0.477
2000 Deora A, Spearman P, Ratner L. The N-terminal matrix domain of HIV-1 Gag is sufficient but not necessary for viral protein U-mediated enhancement of particle release through a membrane-targeting mechanism. Virology. 269: 305-12. PMID 10753709 DOI: 10.1006/Viro.1999.0094  0.513
1999 Varthakavi V, Browning PJ, Spearman P. Human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of Kaposi's sarcoma-associated herpesvirus Journal of Virology. 73: 10329-10338. PMID 10559351 DOI: 10.1128/Jvi.73.12.10329-10338.1999  0.553
1999 Fang ZY, Kuli-Zade I, Spearman P. Efficient human immunodeficiency virus (HIV)-1 Gag-Env pseudovirion formation elicited from mammalian cells by a canarypox HIV vaccine candidate Journal of Infectious Diseases. 180: 1122-1132. PMID 10479139 DOI: 10.1086/315028  0.52
1999 Gicheru MM, Otsyula M, Spearman P, Graham BS, Miller CJ, Robinson HL, Haigwood NL, Montefiori DC. Neutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm) Journal of Medical Primatology. 28: 97-104. PMID 10475110 DOI: 10.1111/J.1600-0684.1999.Tb00257.X  0.321
1999 Wang JJ, Horton R, Varthakavi V, Spearman P, Ratner L. Formation and release of virus-like particles by HIV-1 matrix protein [1] Aids. 13: 281-283. PMID 10202836 DOI: 10.1097/00002030-199902040-00018  0.468
1999 Browning PJ, Varthakavi V, Spearman P. AZT AND INDINAVIR INHIBIT KSHV LYTIC REPLICATION AND TRANSMISSION IN HIV-INFECTED PRIMARY EFFUSION LYMPHOMA CELLS. Jaids: Journal of Acquired Immune Deficiency Syndromes. 21: A22. DOI: 10.1097/00126334-199905010-00070  0.495
1998 Sandefur S, Varthakavi V, Spearman P. The I domain is required for efficient plasma membrane binding of human immunodeficiency virus type 1 Pr55(Gag) Journal of Virology. 72: 2723-2732. PMID 9525590 DOI: 10.1128/Jvi.72.4.2723-2732.1998  0.434
1997 Spearman P, Horton R, Ratner L, Kuli-Zade I. Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism Journal of Virology. 71: 6582-6592. PMID 9261380 DOI: 10.1128/Jvi.71.9.6582-6592.1997  0.445
1997 Stock K, Spearman P. Mutation of serine residues within the matrix protein region of Pr55Gag leads to disruption of replication at distinct stages of the HIV lifecycle Clinical Infectious Diseases. 25: 391.  0.349
1997 Sandefur S, Vartakhavi V, Spearman P. Efficient HIV-1 Gag protein intracellular transport requires a domain within the nucleocapsid protein (NC) region Clinical Infectious Diseases. 25: 391.  0.368
1996 Spearman P, Ratner L. Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates Journal of Virology. 70: 8187-8194. PMID 8892951 DOI: 10.1128/Jvi.70.11.8187-8194.1996  0.603
1994 Spearman P, Wang JJ, Vander Heyden N, Ratner L. Identification of human immunodeficiency virus type 1 gag protein domains essential to membrane binding and particle assembly Journal of Virology. 68: 3232-3242. PMID 8151785 DOI: 10.1128/Jvi.68.5.3232-3242.1994  0.432
1994 Horton R, Spearman P, Ratner L. HIV-2 viral protein X association with the Gag p27 capsid protein Virology. 199: 453-457. PMID 8122374 DOI: 10.1006/Viro.1994.1144  0.48
1994 Spearman P, Wang JJ, Vander Heyden N, Ratner L. Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly. Journal of Virology. 68: 3232-3242. DOI: 10.1128/jvi.68.5.3232-3242.1994  0.339
1993 Lu YL, Spearman P, Ratner L. Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions. Journal of Virology. 67: 6542-50. PMID 8411357 DOI: 10.1128/Jvi.67.11.6542-6550.1993  0.414
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