| Year |
Citation |
Score |
| 2024 |
Touvier T, Veneri FA, Claessens A, Ferri C, Mastrangelo R, Sorgiati N, Bianchi F, Valenzano S, Del Carro U, Rivellini C, Duong P, Shy ME, Kelly JW, Svaren J, Wiseman RL, et al. Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B. Biorxiv : the Preprint Server For Biology. PMID 38352425 DOI: 10.1101/2024.01.31.577760 |
0.502 |
|
| 2023 |
Xie L, Bowman ME, Louie GV, Zhang C, Ardejani MS, Huang X, Chu Q, Donaldson CJ, Vaughan JM, Shan H, Powers ET, Kelly JW, Lyumkis D, Noel JP, Saghatelian A. Biochemistry and Protein Interactions of the CYREN Microprotein. Biochemistry. PMID 37813856 DOI: 10.1021/acs.biochem.3c00397 |
0.802 |
|
| 2023 |
Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Acs Chemical Biology. PMID 37523656 DOI: 10.1021/acschembio.3c00042 |
0.691 |
|
| 2023 |
Perea V, Cole C, Lebeau J, Dolina V, Baron KR, Madhavan A, Kelly JW, Grotjahn DA, Wiseman RL. PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid. The Embo Journal. e113908. PMID 37306086 DOI: 10.15252/embj.2023113908 |
0.448 |
|
| 2023 |
Elsasser S, Elia LP, Morimoto RI, Powers ET, Elsasser S, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Elia LP, Finkbeiner S, ... ... Kelly JW, et al. A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. Biorxiv : the Preprint Server For Biology. PMID 36993380 DOI: 10.1101/2023.03.22.533675 |
0.577 |
|
| 2023 |
Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Biorxiv : the Preprint Server For Biology. PMID 36712115 DOI: 10.1101/2023.01.16.524237 |
0.678 |
|
| 2023 |
Tsai FJ, Jaeger M, Coelho T, Powers ET, Kelly JW. Tafamidis concentration required for transthyretin stabilisation in cerebrospinal fluid. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-11. PMID 36691999 DOI: 10.1080/13506129.2023.2167595 |
0.52 |
|
| 2022 |
Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis. Cell Chemical Biology. PMID 36630963 DOI: 10.1016/j.chembiol.2022.12.004 |
0.514 |
|
| 2022 |
Tsai FJ, Nelson LT, Kline GM, Jäger M, Berk JL, Sekijima Y, Powers ET, Kelly JW. Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-5. PMID 36444793 DOI: 10.1080/13506129.2022.2148094 |
0.648 |
|
| 2022 |
Monteiro C, Mesgarzadeh JS, Anselmo J, Fernandes J, Novais M, Rodrigues C, Powers DL, Powers ET, Coelho T, Kelly JW. Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-15. PMID 36178172 DOI: 10.1080/13506129.2022.2126308 |
0.57 |
|
| 2022 |
Mesgarzadeh JS, Romine IC, Smith-Cohen EM, Grandjean JMD, Kelly JW, Genereux JC, Wiseman RL. ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors. Cells. 11. PMID 35626697 DOI: 10.3390/cells11101661 |
0.579 |
|
| 2022 |
Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW. Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA receptors. Cell & Bioscience. 12: 48. PMID 35477478 DOI: 10.1186/s13578-022-00783-w |
0.586 |
|
| 2022 |
Chiti F, Kelly JW. Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation. Current Opinion in Structural Biology. 72: 267-278. PMID 34999558 DOI: 10.1016/j.sbi.2021.11.009 |
0.309 |
|
| 2021 |
Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. Acs Chemical Biology. PMID 34797633 DOI: 10.1021/acschembio.1c00810 |
0.481 |
|
| 2021 |
Kroeger H, Grandjean JMD, Chiang WJ, Bindels DD, Mastey R, Okalova J, Nguyen A, Powers ET, Kelly JW, Grimsey NJ, Michaelides M, Carroll J, Wiseman RL, Lin JH. ATF6 is essential for human cone photoreceptor development. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34561305 DOI: 10.1073/pnas.2103196118 |
0.656 |
|
| 2021 |
Ardejani MS, Noodleman L, Powers ET, Kelly JW. Stereoelectronic effects in stabilizing protein-N-glycan interactions revealed by experiment and machine learning. Nature Chemistry. PMID 33723379 DOI: 10.1038/s41557-021-00646-w |
0.787 |
|
| 2021 |
Rius B, Mesgarzadeh JS, Romine IC, Paxman RJ, Kelly JW, Wiseman RL. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion. Blood Advances. 5: 1037-1049. PMID 33599742 DOI: 10.1182/bloodadvances.2020002813 |
0.519 |
|
| 2020 |
Kelly J, Powers E. Response. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 33274653 DOI: 10.1080/13506129.2020.1853094 |
0.476 |
|
| 2020 |
Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nature Chemistry. PMID 32868886 DOI: 10.1038/S41557-020-0530-4 |
0.372 |
|
| 2020 |
Nelson LT, Paxman RJ, Xu J, Webb B, Powers ET, Kelly JW. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-6. PMID 32811187 DOI: 10.1080/13506129.2020.1808783 |
0.586 |
|
| 2020 |
Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nature Chemical Biology. PMID 32690944 DOI: 10.1038/S41589-020-0584-Z |
0.796 |
|
| 2020 |
Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorganic & Medicinal Chemistry Letters. 30: 127356. PMID 32631553 DOI: 10.1016/J.Bmcl.2020.127356 |
0.355 |
|
| 2020 |
Dasari AKR, Arreola J, Michael B, Griffin RG, Kelly JW, Lim KH. Disruption of the CD loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway. Biochemistry. PMID 32500705 DOI: 10.1021/Acs.Biochem.0C00079 |
0.403 |
|
| 2020 |
Dasari AKR, Hung I, Michael B, Gan Z, Kelly JW, Connors LH, Griffin RG, Lim KH. Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo. Biochemistry. PMID 32338497 DOI: 10.1021/Acs.Biochem.0C00091 |
0.414 |
|
| 2020 |
Sinha A, Chang JC, Xu P, Gindinova K, Cho Y, Sun W, Wu X, Li YM, Greengard P, Kelly JW, Sinha SC. Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage Acs Medicinal Chemistry Letters. 11: 1973-1979. DOI: 10.1021/Acsmedchemlett.9B00688 |
0.306 |
|
| 2019 |
Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. The role of protein thermodynamics and primary structure in fibrillogenesis of variable domains from immunoglobulin light-chains. Journal of the American Chemical Society. PMID 31364359 DOI: 10.1021/Jacs.9B05499 |
0.386 |
|
| 2019 |
Monteiro C, Mesgazardeh JS, Anselmo J, Fernandes J, Novais M, Rodrigues C, Brighty GJ, Powers DL, Powers ET, Coelho T, Kelly JW. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. Jci Insight. 4. PMID 31217346 DOI: 10.1172/Jci.Insight.126526 |
0.572 |
|
| 2019 |
Ruberg FL, Grogan M, Hanna M, Kelly JW, Maurer MS. Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 73: 2872-2891. PMID 31171094 DOI: 10.1016/J.Jacc.2019.04.003 |
0.314 |
|
| 2019 |
Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/J.Chembiol.2019.04.001 |
0.807 |
|
| 2019 |
Kelly JW. Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases. Cold Spring Harbor Perspectives in Biology. PMID 31088828 DOI: 10.1101/Cshperspect.A034108 |
0.372 |
|
| 2019 |
Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, ... Kelly JW, et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971495 DOI: 10.1073/Pnas.1817567116 |
0.356 |
|
| 2019 |
Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1016/J.Yjmcc.2018.07.047 |
0.765 |
|
| 2018 |
Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proceedings of the National Academy of Sciences of the United States of America. PMID 30598439 DOI: 10.1073/Pnas.1817538116 |
0.352 |
|
| 2018 |
Sun X, Jaeger M, Kelly JW, Dyson J, Wright PE. Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin. Biochemistry. PMID 30540442 DOI: 10.1021/Acs.Biochem.8B01046 |
0.301 |
|
| 2018 |
Lampkin BJ, Monteiro C, Powers ET, Bouc PM, Kelly JW, VanVeller B. A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence. Organic & Biomolecular Chemistry. PMID 30534794 DOI: 10.1039/C8Ob02673D |
0.589 |
|
| 2018 |
Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/Elife.37168 |
0.804 |
|
| 2018 |
Madhivanan K, Greiner ER, Alves-Ferreira M, Soriano-Castell D, Rouzbeh N, Aguirre CA, Paulsson JF, Chapman J, Jiang X, Ooi FK, Lemos C, Dillin A, Prahlad V, Kelly JW, Encalada SE. Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30061394 DOI: 10.1073/Pnas.1801117115 |
0.334 |
|
| 2018 |
Kelly JW. The two shapes of the Tau protein. Elife. 7. PMID 29988017 DOI: 10.7554/Elife.38516 |
0.326 |
|
| 2018 |
Leach BI, Zhang X, Kelly JW, Dyson J, Wright PE. NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations. Biochemistry. PMID 29972637 DOI: 10.1021/Acs.Biochem.8B00642 |
0.376 |
|
| 2018 |
Bamberger C, Martínez-Bartolomé S, Montgomery M, Pankow S, Hulleman JD, Kelly JW, Yates JR. Deducing the presence of proteins and proteoforms in quantitative proteomics. Nature Communications. 9: 2320. PMID 29899466 DOI: 10.1038/S41467-018-04411-5 |
0.683 |
|
| 2018 |
Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/Scisignal.Aan5785 |
0.787 |
|
| 2018 |
Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Author response: Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife. DOI: 10.7554/Elife.37168.022 |
0.761 |
|
| 2018 |
Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Abstract 547: Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.547 |
0.764 |
|
| 2018 |
Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, Wiseman R, Glembotski C. Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Journal of Molecular and Cellular Cardiology. 124: 97. DOI: 10.1016/j.yjmcc.2018.07.047 |
0.751 |
|
| 2018 |
Eisele YS, Janssen ME, Ma D, Nguyen B, Plate L, Morgan GJ, Reixach N, Buxbaum JN, Wiseman RL, Lander GC, Kelly JW. P3-146: Formation And Toxicity Of Transthyretin (Ttr) Oligomers In Vitro And In Patients With Familial Amyloid Polyneuropathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1503 |
0.691 |
|
| 2017 |
Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/Jacs.7B08366 |
0.794 |
|
| 2017 |
Morgan GJ, Usher GA, Kelly JW. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry. PMID 29200282 DOI: 10.1021/Acs.Biochem.7B00579 |
0.437 |
|
| 2017 |
Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/J.Celrep.2017.11.009 |
0.368 |
|
| 2017 |
Morgan GJ, Burkhardt DH, Kelly JW, Powers ET. Translation efficiency is maintained at elevated temperature in E. coli. The Journal of Biological Chemistry. PMID 29183994 DOI: 10.1074/Jbc.Ra117.000284 |
0.567 |
|
| 2017 |
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, ... ... Kelly JW, et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science Translational Medicine. 9. PMID 28904227 DOI: 10.1126/Scitranslmed.Aam7621 |
0.786 |
|
| 2017 |
Lim KH, Dasari AKR, Ma R, Hung I, Gan Z, Kelly JW, Fitzgerald MC. Pathogenic Mutations Induce Partial Structural Changes in Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. Biochemistry. PMID 28820582 DOI: 10.1021/Acs.Biochem.7B00658 |
0.377 |
|
| 2017 |
Ardejani MS, Powers ET, Kelly JW. Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities. Accounts of Chemical Research. PMID 28723063 DOI: 10.1021/Acs.Accounts.7B00195 |
0.795 |
|
| 2017 |
Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/Embj.201695616 |
0.804 |
|
| 2017 |
Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28625364 DOI: 10.1016/J.Bmcl.2017.05.080 |
0.748 |
|
| 2017 |
Fernandes L, Moraes N, Sagrillo FS, Magalhães AV, de Moraes MC, Romão L, Kelly JW, Foguel D, Grimster NP, Palhano FL. An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils. Acs Chemical Neuroscience. PMID 28425704 DOI: 10.1021/Acschemneuro.7B00017 |
0.733 |
|
| 2017 |
Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK. REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28334504 DOI: 10.1002/Art.40104 |
0.564 |
|
| 2016 |
Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MT, Kelly JW, Wiseman RL. Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells. Cell Chemical Biology. PMID 27720586 DOI: 10.1016/J.Chembiol.2016.09.001 |
0.759 |
|
| 2016 |
Lim KH, Dasari AK, Hung IF, Gan Z, Kelly JW, Wright PE, Wemmer DE. Solid-State NMR Studies Reveal Native-like β-sheet Structures in Transthyretin amyloid. Biochemistry. PMID 27589034 DOI: 10.1021/Acs.Biochem.6B00649 |
0.332 |
|
| 2016 |
Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR. Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures. Theranostics. 6: 1792-809. PMID 27570551 DOI: 10.7150/Thno.14584 |
0.319 |
|
| 2016 |
Morgan GJ, Kelly JW. The kinetic stability of a full-length antibody light chain dimer determines whether endoproteolysis can release amyloidogenic variable domains. Journal of Molecular Biology. PMID 27569045 DOI: 10.1016/J.Jmb.2016.08.021 |
0.346 |
|
| 2016 |
Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Kelly JW, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550 |
0.814 |
|
| 2016 |
Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/Elife.18431 |
0.786 |
|
| 2016 |
Hsu CH, Park S, Mortenson DE, Foley BL, Wang X, Woods RJ, Case DA, Powers ET, Wong CH, Dyson HJ, Kelly JW. The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate. Journal of the American Chemical Society. PMID 27249581 DOI: 10.1021/Jacs.6B02879 |
0.586 |
|
| 2016 |
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, ... Kelly JW, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960 |
0.791 |
|
| 2016 |
Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers ET, Johansson J, Westermark GT, Presto J, Ericzon BG, Kelly JW. Current and future treatment of amyloid diseases. Journal of Internal Medicine. PMID 27165517 DOI: 10.1111/Joim.12506 |
0.652 |
|
| 2016 |
Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW. Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chemical Biology. PMID 27128252 DOI: 10.1021/Acschembio.5B01035 |
0.711 |
|
| 2016 |
Lim KH, Dasari AK, Hung I, Gan Z, Kelly JW, Wemmer DE. Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry. PMID 26998642 DOI: 10.1021/Acs.Biochem.6B00164 |
0.339 |
|
| 2016 |
Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis. Neurology and Therapy. PMID 26894299 DOI: 10.1007/S40120-016-0040-X |
0.406 |
|
| 2016 |
Dave K, Jäger M, Nguyen H, Kelly JW, Gruebele M. High-resolution mapping of the folding transition state of a WW domain. Journal of Molecular Biology. PMID 26880334 DOI: 10.1016/J.Jmb.2016.02.008 |
0.342 |
|
| 2016 |
Baranczak A, Kelly JW. A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases. Current Opinion in Chemical Biology. 32: 10-21. PMID 26859714 DOI: 10.1016/J.Cbpa.2016.01.009 |
0.394 |
|
| 2016 |
Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Kelly JW, et al. Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife. DOI: 10.7554/Elife.15550.026 |
0.786 |
|
| 2016 |
Hsu C, Park S, Mortenson DE, Foley B, Wang X, Woods RJ, Case DA, Powers ET, Wong C, Dyson H, Kelly JW. Solution Structure of N-Galactosylated Pin1 WW Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Nc3/Pdb |
0.551 |
|
| 2015 |
Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angewandte Chemie (International Ed. in English). PMID 26696445 DOI: 10.1002/Anie.201509016 |
0.561 |
|
| 2015 |
Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews. Drug Discovery. PMID 26338154 DOI: 10.1038/Nrd4593 |
0.805 |
|
| 2015 |
Liu Y, Zhang X, Chen W, Tan YL, Kelly JW. Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. Journal of the American Chemical Society. PMID 26305239 DOI: 10.1021/Jacs.5B04366 |
0.601 |
|
| 2015 |
Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity. Chemistry & Biology. 22: 1052-62. PMID 26190824 DOI: 10.1016/J.Chembiol.2015.06.017 |
0.785 |
|
| 2015 |
Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/Jacs.5B03042 |
0.685 |
|
| 2015 |
Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell Reports. 11: 321-33. PMID 25843722 DOI: 10.1016/J.Celrep.2015.03.018 |
0.633 |
|
| 2015 |
Hulleman JD, Kelly JW. Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 565-75. PMID 25389134 DOI: 10.1096/Fj.14-255414 |
0.672 |
|
| 2015 |
Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896 |
0.813 |
|
| 2015 |
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto SI, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Correction to supporting information for "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss," Proceedings of the National Academy of Sciences of the United States of America. 112: E3751-E3752. DOI: 10.1073/pnas.1511282112 |
0.484 |
|
| 2015 |
Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.06.017 |
0.769 |
|
| 2014 |
Hebert DN, Lamriben L, Powers ET, Kelly JW. The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis. Nature Chemical Biology. 10: 902-10. PMID 25325701 DOI: 10.1038/Nchembio.1651 |
0.64 |
|
| 2014 |
Liu Y, Zhang X, Tan YL, Bhabha G, Ekiert DC, Kipnis Y, Bjelic S, Baker D, Kelly JW. De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. Journal of the American Chemical Society. 136: 13102-5. PMID 25209927 DOI: 10.1021/Ja5056356 |
0.333 |
|
| 2014 |
Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/Pnas.1406050111 |
0.797 |
|
| 2014 |
Greiner ER, Kelly JW, Palhano FL. Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils. Plos One. 9: e105433. PMID 25144803 DOI: 10.1371/Journal.Pone.0105433 |
0.712 |
|
| 2014 |
Tan YL, Genereux JC, Pankow S, Aerts JM, Yates JR, Kelly JW. ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease. Chemistry & Biology. 21: 967-76. PMID 25126989 DOI: 10.1016/J.Chembiol.2014.06.008 |
0.38 |
|
| 2014 |
Zhang X, Liu Y, Genereux JC, Nolan C, Singh M, Kelly JW. Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. Acs Chemical Biology. 9: 1945-9. PMID 25051296 DOI: 10.1021/Cb5004477 |
0.379 |
|
| 2014 |
Zhang X, Kelly JW. Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding. Journal of Molecular Biology. 426: 2736-8. PMID 24909364 DOI: 10.1016/J.Jmb.2014.06.001 |
0.38 |
|
| 2014 |
Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW. Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry. 53: 1993-2006. PMID 24661308 DOI: 10.1021/Bi500171J |
0.781 |
|
| 2014 |
Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y, Bjelic S, Baker D, Kelly JW. Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proceedings of the National Academy of Sciences of the United States of America. 111: 4449-54. PMID 24591605 DOI: 10.1073/Pnas.1323268111 |
0.437 |
|
| 2014 |
Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers. 101: 484-95. PMID 24105107 DOI: 10.1002/Bip.22407 |
0.663 |
|
| 2013 |
Berk JL, Suhr OB, Obici L, Sekijima Y, Zeldenrust SR, Yamashita T, Heneghan MA, Gorevic PD, Litchy WJ, Wiesman JF, Nordh E, Corato M, Lozza A, Cortese A, Robinson-Papp J, ... ... Kelly JW, et al. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. Jama. 310: 2658-67. PMID 24368466 DOI: 10.1001/Jama.2013.283815 |
0.512 |
|
| 2013 |
Li X, Zhang X, Ladiwala AR, Du D, Yadav JK, Tessier PM, Wright PE, Kelly JW, Buxbaum JN. Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19423-33. PMID 24336709 DOI: 10.1523/Jneurosci.2561-13.2013 |
0.608 |
|
| 2013 |
Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. Journal of the American Chemical Society. 135: 17869-80. PMID 24180271 DOI: 10.1021/Ja408230K |
0.361 |
|
| 2013 |
Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chemical Communications (Cambridge, England). 49: 9188-90. PMID 23989101 DOI: 10.1039/C3Cc44667K |
0.454 |
|
| 2013 |
Murray AN, Palhano FL, Bieschke J, Kelly JW. Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes. Protein Science : a Publication of the Protein Society. 22: 1531-41. PMID 23963844 DOI: 10.1002/Pro.2339 |
0.795 |
|
| 2013 |
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/Pnas.1306832110 |
0.566 |
|
| 2013 |
Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins. Journal of the American Chemical Society. 135: 9877-84. PMID 23742246 DOI: 10.1021/Ja4040472 |
0.756 |
|
| 2013 |
Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110 |
0.631 |
|
| 2013 |
Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/Ja402756P |
0.768 |
|
| 2013 |
Ryno LM, Wiseman RL, Kelly JW. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases. Current Opinion in Chemical Biology. 17: 346-52. PMID 23647985 DOI: 10.1016/J.Cbpa.2013.04.009 |
0.808 |
|
| 2013 |
Palhano FL, Lee J, Grimster NP, Kelly JW. Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils. Journal of the American Chemical Society. 135: 7503-10. PMID 23611538 DOI: 10.1021/Ja3115696 |
0.761 |
|
| 2013 |
Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/J.Celrep.2013.03.024 |
0.792 |
|
| 2013 |
Ong DS, Wang YJ, Tan YL, Yates JR, Mu TW, Kelly JW. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts. Chemistry & Biology. 20: 403-15. PMID 23434032 DOI: 10.1016/J.Chembiol.2012.11.014 |
0.596 |
|
| 2013 |
Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/Ja311729D |
0.621 |
|
| 2013 |
Lim KH, Dyson HJ, Kelly JW, Wright PE. Localized structural fluctuations promote amyloidogenic conformations in transthyretin. Journal of Molecular Biology. 425: 977-88. PMID 23318953 DOI: 10.1016/J.Jmb.2013.01.008 |
0.382 |
|
| 2013 |
Hulleman JD, Brown SJ, Rosen H, Kelly JW. A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of Biomolecular Screening. 18: 647-58. PMID 23230284 DOI: 10.1177/1087057112469405 |
0.683 |
|
| 2013 |
Enck S, Chen W, Price J, Powers E, Wong C, Dyson H, Kelly J. NMR solution structure of Pin1 WW domain mutant 5-1g Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2M9E/Pdb |
0.741 |
|
| 2013 |
Fearns C, Connelly S, Powers ET, Kelly JW. Development of Therapeutic Strategies for the Transthyretin Amyloidoses Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. 373-394. DOI: 10.1002/9783527654185.ch17 |
0.496 |
|
| 2012 |
Fowler DM, Kelly JW. Functional amyloidogenesis and cytotoxicity-insights into biology and pathology. Plos Biology. 10: e1001459. PMID 23300381 DOI: 10.1371/Journal.Pbio.1001459 |
0.657 |
|
| 2012 |
Murray AN, Kelly JW. Hsp104 gives clients the individual attention they need. Cell. 151: 695-7. PMID 23141530 DOI: 10.1016/J.Cell.2012.10.033 |
0.348 |
|
| 2012 |
Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S. A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proceedings of the National Academy of Sciences of the United States of America. 109: 16858-63. PMID 23035249 DOI: 10.1073/Pnas.1209751109 |
0.743 |
|
| 2012 |
Azevedo EP, Guimarães-Costa AB, Torezani GS, Braga CA, Palhano FL, Kelly JW, Saraiva EM, Foguel D. Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase. The Journal of Biological Chemistry. 287: 37206-18. PMID 22918834 DOI: 10.1074/Jbc.M112.369942 |
0.711 |
|
| 2012 |
Hulleman JD, Balch WE, Kelly JW. Translational attenuation differentially alters the fate of disease-associated fibulin proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4548-60. PMID 22872678 DOI: 10.1096/Fj.11-202861 |
0.711 |
|
| 2012 |
Price JL, Culyba EK, Chen W, Murray AN, Hanson SR, Wong CH, Powers ET, Kelly JW. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability. Biopolymers. 98: 195-211. PMID 22782562 DOI: 10.1002/Bip.22030 |
0.79 |
|
| 2012 |
Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/Pnas.1121005109 |
0.811 |
|
| 2012 |
Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L, et al. The Diflunisal Trial: study accrual and drug tolerance. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 19: 37-8. PMID 22551208 DOI: 10.3109/13506129.2012.678509 |
0.49 |
|
| 2012 |
Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics. Journal of the American Chemical Society. 134: 4450-4451. PMID 22500055 DOI: 10.1021/Ja300899D |
0.698 |
|
| 2012 |
Solomon JP, Page LJ, Balch WE, Kelly JW. Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Critical Reviews in Biochemistry and Molecular Biology. 47: 282-96. PMID 22360545 DOI: 10.3109/10409238.2012.661401 |
0.415 |
|
| 2012 |
Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. Journal of Molecular Biology. 421: 185-203. PMID 22244854 DOI: 10.1016/J.Jmb.2011.12.060 |
0.711 |
|
| 2012 |
Fowler DM, Koulov AV, Kelly JW, Balch WE. Mammalian functional amyloid The Functional Fold: Amyloid Structures in Nature. 147-158. DOI: 10.4032/9789814267625 |
0.588 |
|
| 2011 |
Azevedo EP, Pereira HM, Garratt RC, Kelly JW, Foguel D, Palhano FL. Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid. Biochemistry. 50: 11070-83. PMID 22091638 DOI: 10.1021/Bi201365R |
0.737 |
|
| 2011 |
Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 50: 10647-57. PMID 22047104 DOI: 10.1021/Bi201619Z |
0.648 |
|
| 2011 |
Hulleman JD, Kaushal S, Balch WE, Kelly JW. Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration. Molecular Biology of the Cell. 22: 4765-75. PMID 22031286 DOI: 10.1091/Mbc.E11-08-0695 |
0.689 |
|
| 2011 |
Price JL, Powers ET, Kelly JW. N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation. Acs Chemical Biology. 6: 1188-92. PMID 21939258 DOI: 10.1021/Cb200277U |
0.718 |
|
| 2011 |
Lindquist SL, Kelly JW. Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. Cold Spring Harbor Perspectives in Biology. 3. PMID 21900404 DOI: 10.1101/Cshperspect.A004507 |
0.426 |
|
| 2011 |
Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/Scitranslmed.3002473 |
0.65 |
|
| 2011 |
Berk JL, Dyck PJ, Obici L, Zeldenrust SR, Sekijima Y, Yamashita T, Ando Y, Ikeda SI, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Suhr OB. The diflunisal trial: update on study drug tolerance and disease progression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 18: 196-7. PMID 21838485 DOI: 10.3109/13506129.2011.574354073 |
0.414 |
|
| 2011 |
Price JL, Powers DL, Powers ET, Kelly JW. Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts. Proceedings of the National Academy of Sciences of the United States of America. 108: 14127-32. PMID 21825145 DOI: 10.1073/Pnas.1105880108 |
0.732 |
|
| 2011 |
Lee J, Culyba EK, Powers ET, Kelly JW. Amyloid-β forms fibrils by nucleated conformational conversion of oligomers. Nature Chemical Biology. 7: 602-9. PMID 21804535 DOI: 10.1038/Nchembio.624 |
0.702 |
|
| 2011 |
Reinhart PH, Kelly JW. Treating the periphery to ameliorate neurodegenerative diseases. Cell. 145: 813-4. PMID 21663784 DOI: 10.1016/J.Cell.2011.05.031 |
0.3 |
|
| 2011 |
Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochemical and Biophysical Research Communications. 410: 707-13. PMID 21557933 DOI: 10.1016/J.Bbrc.2011.04.133 |
0.797 |
|
| 2011 |
Wiseman RL, Kelly JW. Cell biology. Phosphatase inhibition delays translational recovery. Science (New York, N.Y.). 332: 44-5. PMID 21454777 DOI: 10.1126/Science.1204505 |
0.716 |
|
| 2011 |
Solomon JP, Bourgault S, Powers ET, Kelly JW. Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. Biochemistry. 50: 2486-98. PMID 21348501 DOI: 10.1021/Bi101905N |
0.794 |
|
| 2011 |
Culyba EK, Price JL, Hanson SR, Dhar A, Wong CH, Gruebele M, Powers ET, Kelly JW. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns. Science (New York, N.Y.). 331: 571-5. PMID 21292975 DOI: 10.1126/Science.1198461 |
0.731 |
|
| 2011 |
Choi S, Kelly JW. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorganic & Medicinal Chemistry. 19: 1505-14. PMID 21273081 DOI: 10.1016/J.Bmc.2010.12.050 |
0.493 |
|
| 2011 |
Du D, Murray AN, Cohen E, Kim HE, Simkovsky R, Dillin A, Kelly JW. A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry. 50: 1607-17. PMID 21268584 DOI: 10.1021/Bi1013744 |
0.57 |
|
| 2011 |
Bourgault S, Solomon JP, Reixach N, Kelly JW. Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. Biochemistry. 50: 1001-15. PMID 21194234 DOI: 10.1021/Bi101822Y |
0.731 |
|
| 2011 |
Ong DS, Kelly JW. Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases. Current Opinion in Cell Biology. 23: 231-8. PMID 21146391 DOI: 10.1016/J.Ceb.2010.11.002 |
0.404 |
|
| 2011 |
Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Erratum to “Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs” [Biochem. Biophys. Res. Commun. 410 (2011) 707–713] Biochemical and Biophysical Research Communications. 412: 196. DOI: 10.1016/J.Bbrc.2011.07.093 |
0.787 |
|
| 2010 |
Choi S, Ong DS, Kelly JW. A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate. Journal of the American Chemical Society. 132: 16043-51. PMID 20964336 DOI: 10.1021/Ja104999V |
0.463 |
|
| 2010 |
Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics. Journal of the American Chemical Society. 132: 15359-67. PMID 20936810 DOI: 10.1021/Ja106896T |
0.737 |
|
| 2010 |
Ong DS, Mu TW, Palmer AE, Kelly JW. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nature Chemical Biology. 6: 424-32. PMID 20453863 DOI: 10.1038/Nchembio.368 |
0.537 |
|
| 2010 |
Trivella DB, Bleicher L, Palmieri Lde C, Wiggers HJ, Montanari CA, Kelly JW, Lima LM, Foguel D, Polikarpov I. Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. Journal of Structural Biology. 170: 522-31. PMID 20211733 DOI: 10.1016/J.Jsb.2010.03.002 |
0.372 |
|
| 2010 |
Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW. Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Science : a Publication of the Protein Society. 19: 836-46. PMID 20162625 DOI: 10.1002/Pro.363 |
0.403 |
|
| 2010 |
Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Current Opinion in Structural Biology. 20: 54-62. PMID 20133122 DOI: 10.1016/J.Sbi.2009.12.009 |
0.65 |
|
| 2010 |
Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nature Chemical Biology. 6: 133-9. PMID 20081815 DOI: 10.1038/Nchembio.281 |
0.531 |
|
| 2010 |
Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. Journal of the American Chemical Society. 132: 1359-70. PMID 20043671 DOI: 10.1021/Ja908562Q |
0.656 |
|
| 2010 |
Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 9: 126-34. PMID 20003171 DOI: 10.1111/J.1474-9726.2009.00541.X |
0.548 |
|
| 2010 |
Naik S, Haque I, Degner N, Kornilayev B, Bomhoff G, Hodges J, Khorassani AA, Katayama H, Morris J, Kelly J, Seed J, Fisher MT. Identifying protein stabilizing ligands using GroEL. Biopolymers. 93: 237-51. PMID 19802819 DOI: 10.1002/Bip.21319 |
0.351 |
|
| 2010 |
Johnson SM, Wiseman L, Paulsson JF, Choi S, Powers ET, Buxbaum JN, Kelly JW. Understanding and Ameliorating the TTR Amyloidoses Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 967-1003. DOI: 10.1002/9780470572702.ch45 |
0.66 |
|
| 2009 |
Wiseman RL, Kelly JW. Evolving protein stability through genetic selection. Molecular Cell. 36: 730-1. PMID 20005835 DOI: 10.1016/J.Molcel.2009.11.023 |
0.718 |
|
| 2009 |
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 139: 1157-69. PMID 20005808 DOI: 10.1016/J.Cell.2009.11.014 |
0.534 |
|
| 2009 |
Solomon JP, Yonemoto IT, Murray AN, Price JL, Powers ET, Balch WE, Kelly JW. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry. 48: 11370-80. PMID 19904968 DOI: 10.1021/Bi901368E |
0.733 |
|
| 2009 |
Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 18563-8. PMID 19841277 DOI: 10.1073/Pnas.0804758106 |
0.81 |
|
| 2009 |
Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/Jbc.M109.047449 |
0.667 |
|
| 2009 |
Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Science : a Publication of the Protein Society. 18: 2231-41. PMID 19701939 DOI: 10.1002/Pro.234 |
0.694 |
|
| 2009 |
Jäger M, Dendle M, Kelly JW. Sequence determinants of thermodynamic stability in a WW domain--an all-beta-sheet protein. Protein Science : a Publication of the Protein Society. 18: 1806-13. PMID 19565466 DOI: 10.1002/Pro.172 |
0.386 |
|
| 2009 |
Page LJ, Suk JY, Bazhenova L, Fleming SM, Wood M, Jiang Y, Guo LT, Mizisin AP, Kisilevsky R, Shelton GD, Balch WE, Kelly JW. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 11125-30. PMID 19549824 DOI: 10.1073/Pnas.0811753106 |
0.581 |
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| 2009 |
Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as beta-sheet folding nucleators. Proceedings of the National Academy of Sciences of the United States of America. 106: 11067-72. PMID 19541614 DOI: 10.1073/Pnas.0813012106 |
0.764 |
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| 2009 |
Gao J, Bosco DA, Powers ET, Kelly JW. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins. Nature Structural & Molecular Biology. 16: 684-90. PMID 19525973 DOI: 10.1038/Nsmb.1610 |
0.777 |
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| 2009 |
Bunagan MR, Gao J, Kelly JW, Gai F. Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis. Journal of the American Chemical Society. 131: 7470-6. PMID 19425552 DOI: 10.1021/Ja901860F |
0.596 |
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| 2009 |
Fowler DM, Kelly JW. Aggregating knowledge about prions and amyloid. Cell. 137: 20-2. PMID 19345180 DOI: 10.1016/J.Cell.2009.03.030 |
0.657 |
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| 2009 |
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annual Review of Biochemistry. 78: 959-91. PMID 19298183 DOI: 10.1146/Annurev.Biochem.052308.114844 |
0.654 |
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| 2009 |
Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability. Proceedings of the National Academy of Sciences of the United States of America. 106: 3131-6. PMID 19204290 DOI: 10.1073/Pnas.0810318105 |
0.625 |
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| 2009 |
Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 52: 1115-25. PMID 19191553 DOI: 10.1021/jm801347s |
0.451 |
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| 2008 |
Sekijima Y, Kelly JW, Ikeda S. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Current Pharmaceutical Design. 14: 3219-30. PMID 19075702 DOI: 10.2174/138161208786404155 |
0.569 |
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| 2008 |
Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao J, Powers ET, Gruebele M, Kelly JW. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective. Biopolymers. 90: 751-8. PMID 18844292 DOI: 10.1002/Bip.21101 |
0.802 |
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| 2008 |
Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 51: 6348-58. PMID 18811132 DOI: 10.1021/Jm800435S |
0.497 |
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| 2008 |
Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 134: 769-81. PMID 18775310 DOI: 10.1016/J.Cell.2008.06.037 |
0.771 |
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| 2008 |
Yonemoto IT, Kroon GJ, Dyson HJ, Balch WE, Kelly JW. Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry. 47: 9900-10. PMID 18710262 DOI: 10.1021/Bi800828U |
0.357 |
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| 2008 |
Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. Journal of Molecular Biology. 382: 1157-67. PMID 18662699 DOI: 10.1016/J.Jmb.2008.07.029 |
0.308 |
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| 2008 |
Hurshman Babbes AR, Powers ET, Kelly JW. Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. Biochemistry. 47: 6969-84. PMID 18537267 DOI: 10.1021/Bi800636Q |
0.652 |
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| 2008 |
Gao J, Kelly JW. Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein. Protein Science : a Publication of the Protein Society. 17: 1096-101. PMID 18434500 DOI: 10.1110/Ps.083439708 |
0.57 |
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| 2008 |
Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science (New York, N.Y.). 319: 916-9. PMID 18276881 DOI: 10.1126/Science.1141448 |
0.358 |
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| 2008 |
Liu F, Du D, Fuller AA, Davoren JE, Wipf P, Kelly JW, Gruebele M. An experimental survey of the transition between two-state and downhill protein folding scenarios. Proceedings of the National Academy of Sciences of the United States of America. 105: 2369-74. PMID 18268349 DOI: 10.1073/Pnas.0711908105 |
0.696 |
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| 2008 |
Mu TW, Fowler DM, Kelly JW. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. Plos Biology. 6: e26. PMID 18254660 DOI: 10.1371/Journal.Pbio.0060026 |
0.723 |
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| 2008 |
Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. Journal of Medicinal Chemistry. 51: 260-70. PMID 18095641 DOI: 10.1021/Jm0708735 |
0.484 |
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| 2008 |
Bieschke J, Siegel SJ, Fu Y, Kelly JW. Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Biochemistry. 47: 50-9. PMID 18078350 DOI: 10.1021/Bi701757V |
0.785 |
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| 2008 |
Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins. The Journal of Biological Chemistry. 283: 2098-107. PMID 18006495 DOI: 10.1074/Jbc.M708028200 |
0.379 |
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| 2007 |
Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, et al. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 131: 1059-71. PMID 18083097 DOI: 10.1016/J.Cell.2007.10.014 |
0.59 |
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| 2007 |
Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131: 809-21. PMID 18022373 DOI: 10.1016/J.Cell.2007.10.025 |
0.789 |
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| 2007 |
Yu Z, Sawkar AR, Kelly JW. Pharmacologic chaperoning as a strategy to treat Gaucher disease. The Febs Journal. 274: 4944-50. PMID 17894779 DOI: 10.1111/J.1742-4658.2007.06042.X |
0.779 |
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| 2007 |
Jäger M, Dendle M, Fuller AA, Kelly JW. A cross-strand Trp Trp pair stabilizes the hPin1 WW domain at the expense of function. Protein Science : a Publication of the Protein Society. 16: 2306-13. PMID 17766376 DOI: 10.1110/Ps.072904107 |
0.632 |
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| 2007 |
Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Protein energetics in maturation of the early secretory pathway. Current Opinion in Cell Biology. 19: 359-67. PMID 17686625 DOI: 10.1016/J.Ceb.2007.05.005 |
0.786 |
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| 2007 |
Dillin A, Kelly JW. Medicine. The yin-yang of sirtuins. Science (New York, N.Y.). 317: 461-2. PMID 17656709 DOI: 10.1126/Science.1146585 |
0.329 |
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| 2007 |
Jäger M, Nguyen H, Dendle M, Gruebele M, Kelly JW. Influence of hPin1 WW N-terminal domain boundaries on function, protein stability, and folding. Protein Science : a Publication of the Protein Society. 16: 1495-501. PMID 17586778 DOI: 10.1110/Ps.072775507 |
0.334 |
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| 2007 |
Stewart CR, Wilson LM, Zhang Q, Pham CL, Waddington LJ, Staples MK, Stapleton D, Kelly JW, Howlett GJ. Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation. Biochemistry. 46: 5552-61. PMID 17429947 DOI: 10.1021/Bi602554Z |
0.628 |
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| 2007 |
Fowler DM, Koulov AV, Balch WE, Kelly JW. Functional amyloid--from bacteria to humans. Trends in Biochemical Sciences. 32: 217-24. PMID 17412596 DOI: 10.1016/J.Tibs.2007.03.003 |
0.661 |
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| 2007 |
Siegel SJ, Bieschke J, Powers ET, Kelly JW. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry. 46: 1503-10. PMID 17279615 DOI: 10.1021/Bi061853S |
0.8 |
|
| 2007 |
Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. Journal of Medicinal Chemistry. 50: 94-100. PMID 17201413 DOI: 10.1021/Jm060677I |
0.8 |
|
| 2006 |
Fu Y, Gao J, Bieschke J, Dendle MA, Kelly JW. Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies. Journal of the American Chemical Society. 128: 15948-9. PMID 17165703 DOI: 10.1021/Ja065303T |
0.721 |
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| 2006 |
Sawkar AR, Schmitz M, Zimmer KP, Reczek D, Edmunds T, Balch WE, Kelly JW. Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. Acs Chemical Biology. 1: 235-51. PMID 17163678 DOI: 10.1021/Cb600187Q |
0.805 |
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| 2006 |
Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Molecular Cell. 24: 759-70. PMID 17157258 DOI: 10.1016/J.Molcel.2006.10.027 |
0.561 |
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| 2006 |
Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 127: 803-15. PMID 17110338 DOI: 10.1016/J.Cell.2006.09.043 |
0.358 |
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| 2006 |
Sekijima Y, Dendle MA, Kelly JW. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 236-49. PMID 17107884 DOI: 10.1080/13506120600960882 |
0.574 |
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| 2006 |
Tojo K, Sekijima Y, Kelly JW, Ikeda S. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis. Neuroscience Research. 56: 441-9. PMID 17028027 DOI: 10.1016/J.Neures.2006.08.014 |
0.566 |
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| 2006 |
Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Accounts of Chemical Research. 39: 611-9. PMID 16981677 DOI: 10.1021/Ar0500766 |
0.8 |
|
| 2006 |
Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 57-66. PMID 16911959 DOI: 10.1080/13506120600722449 |
0.831 |
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| 2006 |
Reixach N, Adamski-Werner SL, Kelly JW, Koziol J, Buxbaum JN. Cell based screening of inhibitors of transthyretin aggregation. Biochemical and Biophysical Research Communications. 348: 889-97. PMID 16904635 DOI: 10.1016/J.Bbrc.2006.07.109 |
0.396 |
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| 2006 |
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science (New York, N.Y.). 313: 1604-10. PMID 16902091 DOI: 10.1126/Science.1124646 |
0.697 |
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| 2006 |
Kelly JW. Structural biology: proteins downhill all the way. Nature. 442: 255-6. PMID 16855578 DOI: 10.1038/442255A |
0.339 |
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| 2006 |
Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proceedings of the National Academy of Sciences of the United States of America. 103: 10648-53. PMID 16807295 DOI: 10.1073/Pnas.0600511103 |
0.703 |
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| 2006 |
Cordeiro Y, Kraineva J, Suarez MC, Tempesta AG, Kelly JW, Silva JL, Winter R, Foguel D. Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophysical Journal. 91: 957-67. PMID 16698785 DOI: 10.1529/Biophysj.106.085928 |
0.347 |
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| 2006 |
Kelly JW, Balch WE. The integration of cell and chemical biology in protein folding. Nature Chemical Biology. 2: 224-7. PMID 16619016 DOI: 10.1038/Nchembio0506-224 |
0.302 |
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| 2006 |
Sawkar AR, D'Haeze W, Kelly JW. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease. Cellular and Molecular Life Sciences : Cmls. 63: 1179-92. PMID 16568247 DOI: 10.1007/S00018-005-5437-0 |
0.798 |
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| 2006 |
Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/Nchembio782 |
0.781 |
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| 2006 |
Suk JY, Zhang F, Balch WE, Linhardt RJ, Kelly JW. Heparin accelerates gelsolin amyloidogenesis. Biochemistry. 45: 2234-42. PMID 16475811 DOI: 10.1021/Bi0519295 |
0.412 |
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| 2006 |
Deechongkit S, Nguyen H, Jager M, Powers ET, Gruebele M, Kelly JW. Beta-sheet folding mechanisms from perturbation energetics. Current Opinion in Structural Biology. 16: 94-101. PMID 16442278 DOI: 10.1016/J.Sbi.2006.01.014 |
0.799 |
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| 2006 |
Sörgjerd K, Ghafouri B, Jonsson BH, Kelly JW, Blond SY, Hammarström P. Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis. Journal of Molecular Biology. 356: 469-82. PMID 16376939 DOI: 10.1016/J.Jmb.2005.11.051 |
0.678 |
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| 2006 |
Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. Plos Biology. 4: e6. PMID 16300414 DOI: 10.1371/Journal.Pbio.0040006 |
0.698 |
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| 2006 |
Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Correction: Corrigendum: Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization Nature Chemical Biology. 2: 346-346. DOI: 10.1038/Nchembio0606-346B |
0.774 |
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| 2005 |
Nguyen H, Jäger M, Kelly JW, Gruebele M. Engineering a beta-sheet protein toward the folding speed limit. The Journal of Physical Chemistry. B. 109: 15182-6. PMID 16852923 DOI: 10.1021/Jp052373Y |
0.361 |
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| 2005 |
Powers ET, Deechongkit S, Kelly JW. Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations. Advances in Protein Chemistry. 72: 39-78. PMID 16581372 DOI: 10.1016/S0065-3233(05)72002-7 |
0.796 |
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| 2005 |
Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Accounts of Chemical Research. 38: 911-21. PMID 16359163 DOI: 10.1021/Ar020073I |
0.817 |
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| 2005 |
Wiseman RL, Powers ET, Kelly JW. Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease. Biochemistry. 44: 16612-23. PMID 16342952 DOI: 10.1021/Bi0511484 |
0.81 |
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| 2005 |
Foss TR, Wiseman RL, Kelly JW. The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry. 44: 15525-33. PMID 16300401 DOI: 10.1021/Bi051608T |
0.733 |
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| 2005 |
Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chemistry & Biology. 12: 1235-44. PMID 16298303 DOI: 10.1016/J.Chembiol.2005.09.007 |
0.809 |
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| 2005 |
Page LJ, Suk JY, Huff ME, Lim HJ, Venable J, Yates J, Kelly JW, Balch WE. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis. The Embo Journal. 24: 4124-32. PMID 16281052 DOI: 10.1038/Sj.Emboj.7600872 |
0.757 |
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| 2005 |
Fu Y, Bieschke J, Kelly JW. E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis. Journal of the American Chemical Society. 127: 15366-7. PMID 16262389 DOI: 10.1021/Ja0551382 |
0.684 |
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| 2005 |
Green NS, Foss TR, Kelly JW. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 14545-50. PMID 16195386 DOI: 10.1073/Pnas.0501609102 |
0.619 |
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| 2005 |
Kelly JW. Structural biology: form and function instructions. Nature. 437: 486-7. PMID 16177774 DOI: 10.1038/437486A |
0.34 |
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| 2005 |
Frankenfield KN, Powers ET, Kelly JW. Influence of the N-terminal domain on the aggregation properties of the prion protein. Protein Science : a Publication of the Protein Society. 14: 2154-66. PMID 16046631 DOI: 10.1110/Ps.051434005 |
0.662 |
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| 2005 |
Wiseman RL, Green NS, Kelly JW. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry. 44: 9265-74. PMID 15966751 DOI: 10.1021/Bi050352O |
0.783 |
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| 2005 |
Zhang Q, Kelly JW. Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice? Biochemistry. 44: 9079-85. PMID 15966731 DOI: 10.1021/Bi050378F |
0.636 |
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| 2005 |
Deechongkit S, Powers ET, You SL, Kelly JW. Controlling the morphology of cross beta-sheet assemblies by rational design. Journal of the American Chemical Society. 127: 8562-70. PMID 15941292 DOI: 10.1021/Ja050558C |
0.798 |
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| 2005 |
Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers ET, Kelly JW. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state. Journal of the American Chemical Society. 127: 6662-71. PMID 15869287 DOI: 10.1021/Ja044351F |
0.8 |
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| 2005 |
Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/Ja042929F |
0.768 |
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| 2005 |
Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/J.Cell.2005.01.018 |
0.816 |
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| 2005 |
Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/Jbc.M502799200 |
0.797 |
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| 2005 |
Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry. 44: 4977-83. PMID 15794636 DOI: 10.1021/Bi0501030 |
0.813 |
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| 2005 |
Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/J.Jmb.2005.01.050 |
0.719 |
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| 2005 |
Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. Journal of Medicinal Chemistry. 48: 1576-87. PMID 15743199 DOI: 10.1021/Jm049274D |
0.821 |
|
| 2005 |
Razavi H, Powers ET, Purkey HE, Adamski-Werner SL, Chiang KP, Dendle MT, Kelly JW. Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1075-8. PMID 15686915 DOI: 10.1016/J.Bmcl.2004.12.022 |
0.754 |
|
| 2005 |
You S, Kelly JW. Total synthesis of didmolamides A and B Tetrahedron Letters. 46: 2567-2570. DOI: 10.1016/J.Tetlet.2005.02.097 |
0.577 |
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| 2005 |
You S, Kelly JW. The total synthesis of bistratamides F–I Tetrahedron. 61: 241-249. DOI: 10.1016/J.Tet.2004.10.024 |
0.582 |
|
| 2004 |
Deechongkit S, Dawson PE, Kelly JW. Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations. Journal of the American Chemical Society. 126: 16762-71. PMID 15612714 DOI: 10.1021/Ja045934S |
0.725 |
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| 2004 |
Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & Biology. 11: 1719-28. PMID 15610856 DOI: 10.1016/J.Chembiol.2004.10.009 |
0.678 |
|
| 2004 |
Page LJ, Huff ME, Kelly JW, Balch WE. Ca2+ binding protects against gelsolin amyloidosis. Biochemical and Biophysical Research Communications. 322: 1105-10. PMID 15336957 DOI: 10.1016/J.Bbrc.2004.07.125 |
0.777 |
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| 2004 |
You SL, Deechongkit S, Kelly JW. Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc alpha-amino acids. Organic Letters. 6: 2627-30. PMID 15255707 DOI: 10.1021/Ol049020M |
0.77 |
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| 2004 |
Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW. Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics. Nature. 430: 101-5. PMID 15229605 DOI: 10.1038/Nature02611 |
0.799 |
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| 2004 |
Hurshman AR, White JT, Powers ET, Kelly JW. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization. Biochemistry. 43: 7365-81. PMID 15182180 DOI: 10.1021/Bi049621L |
0.742 |
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| 2004 |
You SL, Kelly JW. Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate. Organic Letters. 6: 1681-3. PMID 15128266 DOI: 10.1021/Ol049439C |
0.587 |
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| 2004 |
Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4752-7. PMID 15034169 DOI: 10.1073/Pnas.0400924101 |
0.817 |
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| 2004 |
Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proceedings of the National Academy of Sciences of the United States of America. 101: 2817-22. PMID 14981241 DOI: 10.1073/Pnas.0400062101 |
0.772 |
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| 2004 |
Miller SR, Sekijima Y, Kelly JW. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 545-52. PMID 14968122 DOI: 10.1038/Labinvest.3700059 |
0.588 |
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| 2004 |
Deechongkit S, You SL, Kelly JW. Synthesis of all nineteen appropriately protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for Boc solid-phase depsi-peptide synthesis. Organic Letters. 6: 497-500. PMID 14961607 DOI: 10.1021/Ol036102M |
0.773 |
|
| 2004 |
Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. Journal of Medicinal Chemistry. 47: 355-74. PMID 14711308 DOI: 10.1021/Jm030347N |
0.387 |
|
| 2004 |
You SL, Kelly JW. Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 71-5. PMID 14695551 DOI: 10.1002/Chem.200305504 |
0.598 |
|
| 2003 |
You SL, Razavi H, Kelly JW. A biomimetic synthesis of thiazolines using hexaphenyloxodiphosphonium trifluoromethanesulfonate. Angewandte Chemie (International Ed. in English). 42: 83-5. PMID 19757597 DOI: 10.1002/Anie.200390059 |
0.56 |
|
| 2003 |
Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA. Biochemistry. 42: 15333-41. PMID 14690443 DOI: 10.1021/Bi0349569 |
0.762 |
|
| 2003 |
Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 426: 905-9. PMID 14685252 DOI: 10.1038/Nature02265 |
0.36 |
|
| 2003 |
Huff ME, Balch WE, Kelly JW. Pathological and functional amyloid formation orchestrated by the secretory pathway. Current Opinion in Structural Biology. 13: 674-82. PMID 14675544 DOI: 10.1016/J.Sbi.2003.10.010 |
0.759 |
|
| 2003 |
You SL, Kelly JW. Total synthesis of dendroamide a: oxazole and thiazole construction using an oxodiphosphonium salt. The Journal of Organic Chemistry. 68: 9506-9. PMID 14629183 DOI: 10.1021/Jo0302657 |
0.581 |
|
| 2003 |
Huff ME, Page LJ, Balch WE, Kelly JW. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. Journal of Molecular Biology. 334: 119-27. PMID 14596804 DOI: 10.1016/J.Jmb.2003.09.029 |
0.748 |
|
| 2003 |
Green NS, Palaninathan SK, Sacchettini JC, Kelly JW. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. Journal of the American Chemical Society. 125: 13404-14. PMID 14583036 DOI: 10.1021/Ja030294Z |
0.598 |
|
| 2003 |
DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. Journal of Molecular Biology. 332: 601-15. PMID 12963370 DOI: 10.1016/S0022-2836(03)00889-1 |
0.816 |
|
| 2003 |
Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 100: 9831-6. PMID 12900507 DOI: 10.1073/Pnas.1734009100 |
0.605 |
|
| 2003 |
Zhang Q, Kelly JW. Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. Biochemistry. 42: 8756-61. PMID 12873136 DOI: 10.1021/Bi030077A |
0.608 |
|
| 2003 |
Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (New York, N.Y.). 300: 2065-71. PMID 12829775 DOI: 10.1126/Science.1083182 |
0.716 |
|
| 2003 |
Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/Anie.200351179 |
0.789 |
|
| 2003 |
Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 42: 6656-63. PMID 12779320 DOI: 10.1021/Bi027319B |
0.813 |
|
| 2003 |
Kelly JW, Balch WE. Amyloid as a natural product. The Journal of Cell Biology. 161: 461-2. PMID 12743097 DOI: 10.1083/Jcb.200304074 |
0.383 |
|
| 2003 |
Ferrão-Gonzales AD, Palmieri L, Valory M, Silva JL, Lashuel H, Kelly JW, Foguel D. Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of Molecular Biology. 328: 963-74. PMID 12729768 DOI: 10.1016/S0022-2836(03)00368-1 |
0.606 |
|
| 2003 |
Lu JR, Perumal S, Powers ET, Kelly JW, Webster JR, Penfold J. Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study. Journal of the American Chemical Society. 125: 3751-7. PMID 12656605 DOI: 10.1021/Ja0292290 |
0.568 |
|
| 2003 |
Nguyen H, Jager M, Moretto A, Gruebele M, Kelly JW. Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation. Proceedings of the National Academy of Sciences of the United States of America. 100: 3948-53. PMID 12651955 DOI: 10.1073/Pnas.0538054100 |
0.314 |
|
| 2003 |
Sekijima Y, Hammarström P, Matsumura M, Shimizu Y, Iwata M, Tokuda T, Ikeda S, Kelly JW. Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 409-17. PMID 12649341 DOI: 10.1097/01.Lab.0000059937.11023.1F |
0.732 |
|
| 2003 |
Hammarström P, Wiseman RL, Powers ET, Kelly JW. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (New York, N.Y.). 299: 713-6. PMID 12560553 DOI: 10.1126/Science.1079589 |
0.825 |
|
| 2003 |
Colfer S, Kelly JW, Powers ET. Factors governing the self-assembly of a β-hairpin peptide at the air-water interface Langmuir. 19: 1312-1318. DOI: 10.1021/La0207668 |
0.58 |
|
| 2003 |
DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615] Journal of Molecular Biology. 334: 175. DOI: 10.1016/S0022-2836(03)01190-2 |
0.793 |
|
| 2002 |
Powers ET, Yang SI, Lieber CM, Kelly JW. Ordered Langmuir-Blodgett films of amphiphilic beta-hairpin peptides imaged by atomic force microscopy. Angewandte Chemie (International Ed. in English). 41: 127-30. PMID 12491460 DOI: 10.1002/1521-3773(20020104)41:1<127::Aid-Anie127>3.0.Co;2-F |
0.548 |
|
| 2002 |
Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 15428-33. PMID 12434014 DOI: 10.1073/Pnas.192582899 |
0.8 |
|
| 2002 |
Kaul R, Deechongkit S, Kelly JW. Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability. Journal of the American Chemical Society. 124: 11900-7. PMID 12358534 DOI: 10.1021/Ja020675X |
0.742 |
|
| 2002 |
Hammarström P, Jiang X, Hurshman AR, Powers ET, Kelly JW. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proceedings of the National Academy of Sciences of the United States of America. 99: 16427-32. PMID 12351683 DOI: 10.1073/Pnas.202495199 |
0.747 |
|
| 2002 |
Sacchettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nature Reviews. Drug Discovery. 1: 267-75. PMID 12120278 DOI: 10.1038/Nrd769 |
0.341 |
|
| 2002 |
Liu K, Kelly JW, Wemmer DE. Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin. Journal of Molecular Biology. 320: 821-32. PMID 12095258 DOI: 10.1016/S0022-2836(02)00471-0 |
0.39 |
|
| 2002 |
McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM, Kelly JW, Robinson CV. Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure (London, England : 1993). 10: 851-63. PMID 12057199 DOI: 10.1016/S0969-2126(02)00771-2 |
0.797 |
|
| 2002 |
Deechongkit S, Kelly JW. The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain. Journal of the American Chemical Society. 124: 4980-6. PMID 11982361 DOI: 10.1021/Ja0123608 |
0.75 |
|
| 2002 |
Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sachettinni J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of Medicinal Chemistry. 45: 321-32. PMID 11784137 DOI: 10.1021/Jm010257N |
0.801 |
|
| 2002 |
Jiang X, Buxbaum JN, Kelly JW. The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 98: 14943-8. PMID 11752443 DOI: 10.1073/Pnas.261419998 |
0.387 |
|
| 2002 |
Jiang X, Kowalski J, Kelly JW. Increasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain. Protein Science : a Publication of the Protein Society. 10: 1454-65. PMID 11420447 DOI: 10.1110/Ps.640101 |
0.348 |
|
| 2001 |
Chen CD, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE. Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization. The Embo Journal. 20: 6277-87. PMID 11707399 DOI: 10.1093/Emboj/20.22.6277 |
0.75 |
|
| 2001 |
White JT, Kelly JW. Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro. Proceedings of the National Academy of Sciences of the United States of America. 98: 13019-24. PMID 11687657 DOI: 10.1073/Pnas.241406698 |
0.626 |
|
| 2001 |
Hammarström P, Schneider F, Kelly JW. Trans-suppression of misfolding in an amyloid disease. Science (New York, N.Y.). 293: 2459-62. PMID 11577236 DOI: 10.1126/Science.1062245 |
0.649 |
|
| 2001 |
Hammarström P, Jiang X, Deechongkit S, Kelly JW. Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry. 40: 11453-9. PMID 11560493 DOI: 10.1021/Bi010673+ |
0.802 |
|
| 2001 |
Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry. 40: 11442-52. PMID 11560492 DOI: 10.1021/Bi011194D |
0.8 |
|
| 2001 |
Jäger M, Nguyen H, Crane JC, Kelly JW, Gruebele M. The folding mechanism of a beta-sheet: the WW domain. Journal of Molecular Biology. 311: 373-93. PMID 11478867 DOI: 10.1006/Jmbi.2001.4873 |
0.351 |
|
| 2001 |
Schneider F, Hammarström P, Kelly JW. Transthyretin slowly exchanges subunits under physiological conditions: A convenient chromatographic method to study subunit exchange in oligomeric proteins. Protein Science : a Publication of the Protein Society. 10: 1606-13. PMID 11468357 DOI: 10.1110/Ps.8901 |
0.595 |
|
| 2001 |
Kaul R, Angeles AR, Jäger M, Powers ET, Kelly JW. Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets. Journal of the American Chemical Society. 123: 5206-12. PMID 11457382 DOI: 10.1021/Ja0102890 |
0.605 |
|
| 2001 |
Powers ET, Kelly JW. Medium-dependent self-assembly of an amphiphilic peptide: direct observation of peptide phase domains at the air-water interface. Journal of the American Chemical Society. 123: 775-6. PMID 11456608 DOI: 10.1021/Ja005528I |
0.555 |
|
| 2001 |
Petrassi HM, Sharpless KB, Kelly JW. The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines. Organic Letters. 3: 139-42. PMID 11429858 DOI: 10.1021/Ol0003533 |
0.709 |
|
| 2001 |
Purkey HE, Dorrell MI, Kelly JW. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proceedings of the National Academy of Sciences of the United States of America. 98: 5566-71. PMID 11344299 DOI: 10.1073/Pnas.091431798 |
0.726 |
|
| 2001 |
Ratnaswamy G, Huff ME, Su AI, Rion S, Kelly JW. Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type. Proceedings of the National Academy of Sciences of the United States of America. 98: 2334-9. PMID 11226240 DOI: 10.1073/Pnas.041452598 |
0.753 |
|
| 2000 |
Lashuel HA, Labrenz SR, Woo L, Serpell LC, Kelly JW. Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 122: 5262-77. PMID 22339465 DOI: 10.1021/Ja9937831 |
0.563 |
|
| 2000 |
Liu K, Cho HS, Hoyt DW, Nguyen TN, Olds P, Kelly JW, Wemmer DE. Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface. Journal of Molecular Biology. 303: 555-65. PMID 11054291 DOI: 10.1006/Jmbi.2000.4164 |
0.407 |
|
| 2000 |
Kelly JW. Mechanisms of amyloidogenesis. Nature Structural & Molecular Biology. 7: 824-826. PMID 11017183 DOI: 10.1038/82815 |
0.343 |
|
| 2000 |
Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Structural Biology. 7: 754-7. PMID 10966644 DOI: 10.1038/78980 |
0.607 |
|
| 2000 |
Crane JC, Koepf EK, Kelly JW, Gruebele M. Mapping the transition state of the WW domain beta-sheet. Journal of Molecular Biology. 298: 283-92. PMID 10764597 DOI: 10.1006/Jmbi.2000.3665 |
0.302 |
|
| 2000 |
Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Rational design of potent human transthyretin amyloid disease inhibitors. Nature Structural Biology. 7: 312-21. PMID 10742177 DOI: 10.1038/74082 |
0.77 |
|
| 2000 |
Kelly JW, Petrassi HM, Oza V, Purkey H, Koepf E, Raman P, Klabunde T, Sacchettini J. Structure-Based Design, Synthesis and Evaluation of Amyloid Fibril Inhibitors Biochemical Society Transactions. 28: A51-A51. DOI: 10.1042/Bst028A051 |
0.793 |
|
| 2000 |
Petrassi HM, Klabunde T, Sacchettini J, Kelly JW. Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors Journal of the American Chemical Society. 122: 2178-2192. DOI: 10.1021/Ja993309V |
0.765 |
|
| 1999 |
Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. Biochemistry. 38: 14338-51. PMID 10572009 DOI: 10.1021/bi991105l |
0.795 |
|
| 1999 |
Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 38: 13560-73. PMID 10521263 DOI: 10.1021/Bi991021C |
0.591 |
|
| 1999 |
Koo EH, Lansbury PT, Kelly JW. Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 96: 9989-90. PMID 10468546 DOI: 10.1073/Pnas.96.18.9989 |
0.42 |
|
| 1999 |
Baures PW, Oza VB, Peterson SA, Kelly JW. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorganic & Medicinal Chemistry. 7: 1339-47. PMID 10465408 DOI: 10.1016/S0968-0896(99)00066-8 |
0.685 |
|
| 1999 |
Ratnaswamy G, Koepf E, Bekele H, Yin H, Kelly JW. The amyloidogenicity of gelsolin is controlled by proteolysis and pH. Chemistry & Biology. 6: 293-304. PMID 10322122 DOI: 10.1016/S1074-5521(99)80075-1 |
0.348 |
|
| 1999 |
Koepf EK, Petrassi HM, Sudol M, Kelly JW. WW: An isolated three-stranded antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state. Protein Science : a Publication of the Protein Society. 8: 841-53. PMID 10211830 DOI: 10.1110/Ps.8.4.841 |
0.745 |
|
| 1999 |
Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & Medicinal Chemistry. 7: 39-59. PMID 10199655 DOI: 10.1016/S0968-0896(98)00222-3 |
0.565 |
|
| 1999 |
Oza VB, Petrassi HM, Purkey HE, Kelly JW. Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 1-6. PMID 9990446 DOI: 10.1016/S0960-894X(98)00696-9 |
0.801 |
|
| 1998 |
Lashuel HA, Lai Z, Kelly JW. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 37: 17851-64. PMID 9922152 DOI: 10.1021/Bi981876+ |
0.601 |
|
| 1998 |
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/Bi981733N |
0.569 |
|
| 1998 |
Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/Pnas.95.22.12956 |
0.783 |
|
| 1998 |
Baures PW, Peterson SA, Kelly JW. Discovering transthyretin amyloid fibril inhibitors by limited screening. Bioorganic & Medicinal Chemistry. 6: 1389-401. PMID 9784876 DOI: 10.1016/S0968-0896(98)00130-8 |
0.725 |
|
| 1998 |
Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification. 14: 31-7. PMID 9758748 DOI: 10.1006/Prep.1998.0944 |
0.582 |
|
| 1998 |
Nettleton EJ, Sunde M, Lai Z, Kelly JW, Dobson CM, Robinson CV. Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry. Journal of Molecular Biology. 281: 553-64. PMID 9698569 DOI: 10.1006/Jmbi.1998.1937 |
0.407 |
|
| 1998 |
Kelly JW. The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways. Current Opinion in Structural Biology. 8: 101-6. PMID 9519302 DOI: 10.1016/S0959-440X(98)80016-X |
0.427 |
|
| 1998 |
Kelly JW. The environmental dependency of protein folding best explains prion and amyloid diseases. Proceedings of the National Academy of Sciences of the United States of America. 95: 930-2. PMID 9448261 DOI: 10.1073/Pnas.95.3.930 |
0.433 |
|
| 1997 |
Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in Protein Chemistry. 50: 161-81. PMID 9338081 DOI: 10.1016/S0065-3233(08)60321-6 |
0.779 |
|
| 1997 |
Lai Z, McCulloch J, Lashuel HA, Kelly JW. Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 36: 10230-9. PMID 9254621 DOI: 10.1021/Bi963195P |
0.578 |
|
| 1997 |
Chen HI, Einbond A, Kwak SJ, Linn H, Koepf E, Peterson S, Kelly JW, Sudol M. Characterization of the WW domain of human Yes-associated protein and its polyproline-containing ligands Journal of Biological Chemistry. 272: 17070-17077. PMID 9202023 DOI: 10.1074/Jbc.272.27.17070 |
0.338 |
|
| 1997 |
Kelly JW. Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases Structure. 5: 595-600. PMID 9195890 DOI: 10.1016/S0969-2126(97)00215-3 |
0.43 |
|
| 1996 |
McWilliams K, Kelly JW. Synthesis and Conformational Preferences of a Potential beta-Sheet Nucleator Based on the 9,9-Dimethylxanthene Skeleton. The Journal of Organic Chemistry. 61: 7408-7414. PMID 11667668 DOI: 10.1021/Jo9605758 |
0.31 |
|
| 1996 |
Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 93: 15051-6. PMID 8986762 DOI: 10.1073/Pnas.93.26.15051 |
0.636 |
|
| 1996 |
Colon W, Lai Z, McCutchen SL, Miroy GJ, Strang C, Kelly JW. FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation. Ciba Foundation Symposium. 199: 228-38; discussion 2. PMID 8915613 |
0.666 |
|
| 1996 |
Kelly JW. Alternative conformations of amyloidogenic proteins govern their behavior. Current Opinion in Structural Biology. 6: 11-17. PMID 8696966 DOI: 10.1016/S0959-440X(96)80089-3 |
0.414 |
|
| 1996 |
Lai Z, Colón W, Kelly JW. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry. 35: 6470-82. PMID 8639594 DOI: 10.1021/Bi952501G |
0.679 |
|
| 1996 |
Choo DW, Schneider JP, Graciani NR, Kelly JW. Nucleated Antiparallel β-Sheet That Folds and Undergoes Self-Assembly: A Template Promoted Folding Strategy toward Controlled Molecular Architectures Macromolecules. 29: 355-366. DOI: 10.1021/Ma950703E |
0.537 |
|
| 1995 |
Graciani NR, Tsang KY, McCutchen SL, Kelly JW. Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to biologically active peptidomimetics. Bioorganic & Medicinal Chemistry. 2: 999-1006. PMID 7712134 DOI: 10.1016/S0968-0896(00)82048-9 |
0.313 |
|
| 1995 |
McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease. Biochemistry. 34: 13527-36. PMID 7577941 DOI: 10.1021/Bi00041A032 |
0.686 |
|
| 1995 |
Schneider JP, Kelly JW. Synthesis and Efficacy of Square Planar Copper Complexes Designed to Nucleate .beta.-Sheet Structure Journal of the American Chemical Society. 117: 2533-2546. DOI: 10.1021/Ja00114A016 |
0.507 |
|
| 1995 |
Schneider JP, Kelly JW. Templates That Induce .alpha.-Helical, .beta.-Sheet, and Loop Conformations Chemical Reviews. 95: 2169-2187. DOI: 10.1021/Cr00038A015 |
0.509 |
|
| 1994 |
McCutchen SL, Kelly JW. Intermolecular disulfide linkages are not required for transthyretin amyloid fibril formation in vitro. Biochemical and Biophysical Research Communications. 197: 415-21. PMID 8267575 DOI: 10.1006/Bbrc.1993.2495 |
0.41 |
|
| 1994 |
Kelly JW, Lansbury PT. A chemical approach to elucidate tin mechanism of transthyretin and βprotein amyloid fibril formation Amyloid. 1: 186-205. DOI: 10.3109/13506129409148451 |
0.413 |
|
| 1993 |
McCutchen SL, Colon W, Kelly JW. Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity. Biochemistry. 32: 12119-27. PMID 8218290 DOI: 10.1021/Bi00096A024 |
0.708 |
|
| 1992 |
Colon W, Kelly JW. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31: 8654-60. PMID 1390650 DOI: 10.1021/Bi00151A036 |
0.687 |
|
| 1992 |
Schneider JP, Topgi RS, Kelly JW. A Convenient Synthesis of 6,6′-Diamino-2,2′-Bipyridine Synthetic Communications. 22: 1033-1037. DOI: 10.1080/00397919208019294 |
0.464 |
|
| 1989 |
Kaiser ET, Mihara H, Laforet GA, Kelly JW, Walters L, Findeis MA, Sasaki T. Peptide and protein synthesis by segment synthesis-condensation. Science (New York, N.Y.). 243: 187-92. PMID 2492114 DOI: 10.1126/Science.2492114 |
0.544 |
|
| 1989 |
Scheim U, Rühlmann K, Kelly JW, Evans SA. Synthesis of siloxanes. XVII. Increment system for the prediction of 17O NMR shifts of siloxanes Journal of Organometallic Chemistry. 375: 33-37. DOI: 10.1016/0022-328X(89)85080-6 |
0.597 |
|
| 1988 |
Kelly JW. New Tools for Probing Protein Structure Nature Biotechnology. 6: 125-129. DOI: 10.1038/Nbt0288-125 |
0.33 |
|
| 1988 |
Rühlmann K, Scheim U, Evans SA, Kelly JW, Bassindale AR. Synthesis of siloxanes. V. Oxygen-17 NMR spectroscopy Journal of Organometallic Chemistry. 340: 19-21. DOI: 10.1016/0022-328X(88)80548-5 |
0.597 |
|
| 1987 |
Kelly JW, Robinson PL, Evans SA. Dioxyphosphoranes, an Emerging Class of Versatile Reagents for Organic Synthesis Phosphorous and Sulfur and the Related Elements. 30: 147-150. DOI: 10.1080/03086648708080543 |
0.628 |
|
| 1987 |
Robinson PL, Kelly JW, Evans SA. THE CHEMISTRY OF α, ω-MERCAPTOALCOHOLS IN THE PRESENCE OF DIETHOXYTRIPHENYLPHOSPHORANE. TEMPERATURE DEPENDENCE OF CYCLODEHYDRATIONS AND S-ETHYLATIONS Phosphorous and Sulfur and the Related Elements. 31: 59-70. DOI: 10.1080/03086648708079342 |
0.606 |
|
| 1987 |
Murray WT, Kelly JW, Evans SA. Synthesis of substituted 1,4-oxathianes. Mechanistic details of diethoxytriphenylphosphorane and triphenylphosphine/tetrachloromethane-promoted cyclodehydrations and carbon-13 NMR spectroscopy The Journal of Organic Chemistry. 52: 525-529. DOI: 10.1021/Jo00380A009 |
0.606 |
|
| 1987 |
Kelly JW, Evans SA. Oxygen-17 NMR spectral studies of selected aromatic sulfones Magnetic Resonance in Chemistry. 25: 305-308. DOI: 10.1002/Mrc.1260250406 |
0.605 |
|
| 1986 |
Kelly JW, Evans SA. Regioselective phosphoranylation and cyclodehydration of triols with diethoxytriphenylphosphorane. Journal of the American Chemical Society. 108: 7681-7685. PMID 22283274 DOI: 10.1021/Ja00284A036 |
0.604 |
|
| 1986 |
Robinson PL, Evans SA, Kelly JW. The Synthetic Utility Of Dioxyphosphoranes In Organic Synthesis Phosphorous and Sulfur and the Related Elements. 26: 15-24. DOI: 10.1080/03086648608084565 |
0.611 |
|
| 1986 |
Kelly JW, Evans SA. Bis(neopentyloxy)triphenylphosphorane: a versatile, nonalkylating cyclodehydration reagent The Journal of Organic Chemistry. 51: 5490-5492. DOI: 10.1021/Jo00376A103 |
0.591 |
|
| 1986 |
Kelly JW, Robinson PL, Evans SA. 2,2,2-Triphenyl-4,5-(2',2"-biphenylene)-1,3,2-dioxaphospholane: an effective reagent for converting diols, amino alcohols, and especially mercapto alcohols to the corresponding heterocycles The Journal of Organic Chemistry. 51: 4473-4475. DOI: 10.1021/Jo00373A026 |
0.588 |
|
| 1986 |
Kelly JW, Anderson NL, Evans SA. Cyclodehydration of N- and C-substituted .beta.-amino alcohols to the corresponding aziridines with diethoxytriphenylphosphorane The Journal of Organic Chemistry. 51: 95-97. DOI: 10.1021/Jo00351A020 |
0.614 |
|
| 1985 |
Kelly JW, Robinson PL, Evans SA. Diethoxydiphenylpolystyrylphosphorane: a new polymeric reagent for the efficient cyclodehydration of simple diols The Journal of Organic Chemistry. 50: 5007-5009. DOI: 10.1002/Chin.198621087 |
0.601 |
|
| 1985 |
Robinson PL, Barry CN, Kelly JW, Evans SA. Diethoxytriphenylphosphorane: a mild, regioselective cyclodehydrating reagent for conversion of diols to cyclic ethers: stereochemistry, synthetic utility, and scope Journal of the American Chemical Society. 107: 5210-5219. DOI: 10.1002/Chin.198551241 |
0.615 |
|
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