Dennis Roop - Publications

Affiliations: 
University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Molecular Biology, Cell Biology, Genetics

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pavlova M, Balaiya V, Flores JC, Ferreyros M, Bush K, Hopkin A, Kogut I, Roop DR, Bilousova G. The Development of an Advanced Model for Multilayer Human Skin Reconstruction In Vivo. Bio-Protocol. 14: e4919. PMID 38268973 DOI: 10.21769/BioProtoc.4919  0.313
2021 Ishitsuka Y, Roop DR. The Epidermis: Redox Governor of Health and Diseases. Antioxidants (Basel, Switzerland). 11. PMID 35052551 DOI: 10.3390/antiox11010047  0.338
2020 Ishitsuka Y, Ogawa T, Roop D. The KEAP1/NRF2 Signaling Pathway in Keratinization. Antioxidants (Basel, Switzerland). 9. PMID 32823937 DOI: 10.3390/Antiox9080751  0.4
2020 Goldstein NB, Steel A, Barbulescu CC, Koster MI, Wright MJ, Jones KL, Gao B, Ward B, Woessner B, Trottier Z, Pakieser J, Hu J, Lambert KA, Shellman YG, Fujita M, ... ... Roop DR, et al. MELANOCYTE PRECURSORS IN THE HAIR FOLLICLE BULGE OF REPIGMENTED VITILIGO SKIN ARE CONTROLLED BY RHO-GTPase, KCTD10 AND CTNNB1 SIGNALING. The Journal of Investigative Dermatology. PMID 32800877 DOI: 10.1016/j.jid.2020.07.016  0.328
2020 Ogawa T, Ishitsuka Y, Nakamura Y, Kubota N, Saito A, Fujisawa Y, Watanabe R, Okiyama N, Suga Y, Roop DR, Fujimoto M. NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy. Journal of Immunology (Baltimore, Md. : 1950). PMID 32690656 DOI: 10.4049/jimmunol.2000274  0.346
2020 Ishitsuka Y, Roop DR. Loricrin: Past, Present, and Future. International Journal of Molecular Sciences. 21. PMID 32218335 DOI: 10.3390/ijms21072271  0.323
2019 Torkelson J, Hansen C, Jackow J, Guo Z, Hui-Zhen H, Hayashi R, Sallee B, McCarthy K, Neumayer G, McGrath P, Bilousova G, Kogut I, Roop D, Christiano A, Wernig M, et al. 1036 Scalable production of CRISPR-corrected autologous iPSC derived skin grafts to treat epidermolysis bullosa Journal of Investigative Dermatology. 139: S179. DOI: 10.1016/J.Jid.2019.03.1112  0.315
2018 Crumrine D, Khnykin D, Krieg P, Man MQ, Celli A, Mauro TM, Wakefield JS, Menon G, Mauldin E, Miner JH, Lin MH, Brash AR, Sprecher E, Radner FPW, Choate K, ... Roop D, et al. Perspective: Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope. The Journal of Investigative Dermatology. PMID 30471252 DOI: 10.1016/J.Jid.2018.11.005  0.314
2018 Caldwell C, Krug A, Goldstein N, Koster M, Ward B, Roop D, Norris D, Birlea S. 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis Journal of Investigative Dermatology. 138: S212. DOI: 10.1016/J.JID.2018.03.1265  0.323
2017 Goldstein NB, Koster MI, Jones KL, Gao B, Hoaglin LG, Robinson SE, Wright MJ, Birlea SI, Luman A, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, et al. Repigmentation of Human Vitiligo Skin by NBUVB is Controlled by Transcription of GLI1 and Activation of β-Catenin Pathway in the Hair Follicle Bulge Stem Cells. The Journal of Investigative Dermatology. PMID 29054607 DOI: 10.1016/j.jid.2017.09.040  0.351
2017 Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. PMID 28459465 DOI: 10.1038/Onc.2017.117  0.318
2016 Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. Plos One. 11: e0161465. PMID 27551807 DOI: 10.1371/Journal.Pone.0161465  0.347
2016 Ishitsuka Y, Huebner AJ, Rice RH, Koch PJ, Speransky VV, Steven AC, Roop DR. Lce1 family members are Nrf2-target genes that are induced to compensate for the loss of loricrin. The Journal of Investigative Dermatology. PMID 27167730 DOI: 10.1016/J.Jid.2016.04.022  0.713
2016 Ishitsuka Y, Roop D. The Nrf2/Keap1 pathway contributes to the pathogenesis of atopic dermatitis by directly regulating the IL33/ST2 pathway in the epidermis Journal of Dermatological Science. 84. DOI: 10.1016/J.Jdermsci.2016.08.385  0.305
2015 Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Löffler-Wirth H, et al. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. The Journal of Cell Biology. 211: 1057-75. PMID 26644517 DOI: 10.1083/jcb.201404147  0.348
2015 Rorke EA, Adhikary G, Young CA, Roop DR, Eckert RL. Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype. The Journal of Investigative Dermatology. 135: 170-80. PMID 25050598 DOI: 10.1038/jid.2014.310  0.316
2014 Schäfer M, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, et al. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. Embo Molecular Medicine. 6: 442-57. PMID 24503019 DOI: 10.1002/Emmm.201303281  0.724
2013 Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death and Differentiation. 20: 1080-8. PMID 23686138 DOI: 10.1038/Cdd.2013.41  0.448
2013 Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR. Aurora kinase-A deficiency during skin development impairs cell division and stratification. The Journal of Investigative Dermatology. 133: 78-86. PMID 22832491 DOI: 10.1038/Jid.2012.249  0.709
2012 Huebner AJ, Dai D, Morasso M, Schmidt EE, Schäfer M, Werner S, Roop DR. Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Developmental Cell. 23: 1238-46. PMID 23237955 DOI: 10.1016/J.Devcel.2012.11.002  0.702
2012 Schäfer M, Farwanah H, Willrodt AH, Huebner AJ, Sandhoff K, Roop D, Hohl D, Bloch W, Werner S. Nrf2 links epidermal barrier function with antioxidant defense. Embo Molecular Medicine. 4: 364-79. PMID 22383093 DOI: 10.1002/Emmm.201200219  0.717
2011 Franco HL, Dai D, Lee KY, Rubel CA, Roop D, Boerboom D, Jeong JW, Lydon JP, Bagchi IC, Bagchi MK, DeMayo FJ. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1176-87. PMID 21163860 DOI: 10.1096/Fj.10-175349  0.372
2011 Dai D, Zhu H, Wlodarczyk B, Zhang L, Li L, Li AG, Finnell RH, Roop DR, Chen J. Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. The Journal of Investigative Dermatology. 131: 302-10. PMID 20962855 DOI: 10.1038/jid.2010.306  0.353
2011 Huebner A, Schmidt E, Werner S, Roop D. The Nrf2/Keap1 pathway acts as an epidermal sentinel in utero to ensure the formation of a functional barrier Developmental Biology. 356: 158. DOI: 10.1016/J.Ydbio.2011.05.585  0.697
2009 Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell & Melanoma Research. 22: 761-72. PMID 19845874 DOI: 10.1111/J.1755-148X.2009.00603.X  0.303
2009 Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Research. 69: 7207-15. PMID 19738056 DOI: 10.1158/0008-5472.Can-09-1059  0.34
2009 Koster MI, Marinari B, Payne AS, Kantaputra PN, Costanzo A, Roop DR. DeltaNp63 knockdown mice: A mouse model for AEC syndrome. American Journal of Medical Genetics. Part A. 149: 1942-7. PMID 19681108 DOI: 10.1002/ajmg.a.32794  0.375
2008 Roop D, Toftgård R. Hedgehog in Wnterland. Nature Genetics. 40: 1040-1. PMID 19165916 DOI: 10.1038/Ng0908-1040  0.341
2008 Guttormsen J, Koster MI, Stevens JR, Roop DR, Williams T, Winger QA. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Developmental Biology. 317: 187-95. PMID 18353300 DOI: 10.1016/J.Ydbio.2008.02.017  0.365
2007 Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 3255-60. PMID 17360634 DOI: 10.1073/pnas.0611376104  0.326
2007 Rothnagel JA, Longley MA, Bundman D, Greenhalgh DA, Dominey AM, Roop DR. Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders. The Journal of Investigative Dermatology. 95: 59S-61S. PMID 16788636 DOI: 10.1111/1523-1747.EP12505805  0.323
2006 Geng S, Mezentsev A, Kalachikov S, Raith K, Roop DR, Panteleyev AA. Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function. Journal of Cell Science. 119: 4901-12. PMID 17105764 DOI: 10.1242/jcs.03282  0.429
2006 Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Developmental Biology. 299: 122-36. PMID 16949565 DOI: 10.1016/J.Ydbio.2006.07.015  0.399
2005 Koster MI, Roop DR. Asymmetric cell division in skin development: a new look at an old observation. Developmental Cell. 9: 444-6. PMID 16198286 DOI: 10.1016/j.devcel.2005.09.009  0.301
2005 Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Developmental Cell. 8: 665-76. PMID 15866158 DOI: 10.1016/J.Devcel.2005.02.016  0.324
2003 Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nature Genetics. 35: 238-45. PMID 14517554 DOI: 10.1038/Ng1248  0.315
2002 Cao T, Tsai SY, O'Malley BW, Wang XJ, Roop DR. The epidermis as a bioreactor: topically regulated cutaneous delivery into the circulation. Human Gene Therapy. 13: 1075-80. PMID 12067440 DOI: 10.1089/104303402753812476  0.335
2000 Koch PJ, de Viragh PA, Scharer E, Bundman D, Longley MA, Bickenbach J, Kawachi Y, Suga Y, Zhou Z, Huber M, Hohl D, Kartasova T, Jarnik M, Steven AC, Roop DR. Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. The Journal of Cell Biology. 151: 389-400. PMID 11038185 DOI: 10.1083/Jcb.151.2.389  0.397
2000 Wojcik SM, Bundman DS, Roop DR. Delayed wound healing in keratin 6a knockout mice. Molecular and Cellular Biology. 20: 5248-55. PMID 10866680 DOI: 10.1128/MCB.20.14.5248-5255.2000  0.326
2000 Berton TR, Wang XJ, Zhou Z, Kellendonk C, Schütz G, Tsai S, Roop DR. Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis (New York, N.Y. : 2000). 26: 160-1. PMID 10686618 DOI: 10.1002/(SICI)1526-968X(200002)26:2<160::AID-GENE20>3.0.CO;2  0.3
1999 Wang XJ, Liefer KM, Tsai S, O'Malley BW, Roop DR. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. Proceedings of the National Academy of Sciences of the United States of America. 96: 8483-8. PMID 10411901 DOI: 10.1073/PNAS.96.15.8483  0.306
1998 Rodríguez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation Oncogene. 16: 853-863. PMID 9484776 DOI: 10.1038/Sj.Onc.1201610  0.432
1996 Bickenbach JR, Longley MA, Bundman DS, Dominey AM, Bowden PE, Rothnagel JA, Roop DR. A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis. Differentiation; Research in Biological Diversity. 61: 129-39. PMID 8983179 DOI: 10.1046/J.1432-0436.1996.6120129.X  0.346
1995 Roop D. Defects in the barrier Science. 267: 474-475. PMID 7529942 DOI: 10.1126/Science.7529942  0.309
1993 Robles AI, Gimenez-Conti IB, Roop D, Slaga TJ, Conti CJ. Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors. Molecular Carcinogenesis. 7: 94-8. PMID 7681292 DOI: 10.1002/Mc.2940070207  0.341
1991 Yuspa SH, Kilkenny A, Cheng C, Roop D, Hennings H, Kruszewski F, Lee E, Strickland J, Greenhalgh DA. Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis. Environmental Health Perspectives. 93: 3-10. PMID 1773799 DOI: 10.1289/Ehp.91933  0.394
1991 Huitfeldt HS, Heyden A, Clausen OPF, Thrane EV, Roop D, Yuspa SH. Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors Carcinogenesis. 12: 2063-2067. PMID 1718620 DOI: 10.1093/Carcin/12.11.2063  0.375
1990 Yuspa SH, Hennings H, Roop D, Strickland J, Greenhalgh DA. The malignant conversion step of mouse skin carcinogenesis. Environmental Health Perspectives. 88: 193-195. PMID 2272314 DOI: 10.1289/Ehp.9088193  0.338
1990 Cheng C, Kilkenny AE, Roop D, Yuspa SH. The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Molecular Carcinogenesis. 3: 363-373. PMID 1703765 DOI: 10.1002/Mc.2940030608  0.331
1988 Rogers GE, Martinet N, Steinert P, Wynn P, Roop D, Kilkenny A, Morgan D, Yuspa SH. A procedure for the culture of hair follicles as functionally intact organoids Clinics in Dermatology. 6: 36-41. PMID 2463868 DOI: 10.1016/0738-081X(88)90064-8  0.357
1987 Rogers G, Martinet N, Steinert P, Wynn P, Roop D, Kilkenny A, Morgan D, Yuspa SH. Cultivation of murine hair follicles as organoids in a collagen matrix Journal of Investigative Dermatology. 89: 369-379. PMID 2822817 DOI: 10.1111/1523-1747.Ep12471760  0.37
1986 Roop DR, Lowy DR, Tambourin PE, Strickland J, Harper JR, Balaschak M, Spangler EF, Yuspa SH. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature. 323: 822-4. PMID 2430189 DOI: 10.1038/323822a0  0.332
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