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Keriann M. Backus - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Chemical Biology
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18/38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Julio AR, Shikwana F, Truong C, Burton NR, Dominguez E, Turmon AC, Cao J, Backus K. Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds. Biorxiv : the Preprint Server For Biology. PMID 38014036 DOI: 10.1101/2023.10.30.564067  0.329
2023 Yan T, Boatner LM, Cui L, Tontonoz P, Backus KM. Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics. Biorxiv : the Preprint Server For Biology. PMID 37904933 DOI: 10.1101/2023.10.17.562832  0.302
2023 Khan RMN, Ahn YM, Marriner GA, Via LE, D'Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, ... ... Backus KM, et al. Distributable, Metabolic PET Reporting of Tuberculosis. Biorxiv : the Preprint Server For Biology. PMID 37333343 DOI: 10.1101/2023.04.03.535218  0.39
2020 Xu JH, Eberhardt J, Hill-Payne B, Gonzalez-Paez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity. Acs Chemical Biology. PMID 31927936 DOI: 10.1021/Acschembio.0C00019  0.509
2019 Backus KM, Cao J, Maddox SM. Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorganic & Medicinal Chemistry. PMID 31204229 DOI: 10.1016/J.Bmc.2019.05.050  0.432
2018 Backus KM. Applications of Reactive Cysteine Profiling. Current Topics in Microbiology and Immunology. PMID 30105421 DOI: 10.1007/82_2018_120  0.416
2017 Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. Global profiling of lysine reactivity and ligandability in the human proteome. Nature Chemistry. 9: 1181-1190. PMID 29168484 DOI: 10.1038/Nchem.2826  0.569
2017 Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. PMID 28965760 DOI: 10.1016/J.Cell.2017.08.051  0.641
2017 Touchette MH, Van Vlack E, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link Between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Acs Infectious Diseases. PMID 28276676 DOI: 10.1021/Acsinfecdis.6B00179  0.49
2017 Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. PMID 28111075 DOI: 10.1016/J.Cell.2016.12.021  0.464
2016 Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Covalent Modulators of the Vacuolar ATPase. Journal of the American Chemical Society. PMID 28010062 DOI: 10.1021/Jacs.6B12511  0.5
2016 Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. Journal of the American Chemical Society. PMID 27689866 DOI: 10.1021/Jacs.6B07830  0.638
2016 Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Science Signaling. 9: rs10. PMID 27625306 DOI: 10.1126/Scisignal.Aaf7694  0.639
2016 Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 166: 126-139. PMID 27368101 DOI: 10.1016/J.Cell.2016.05.042  0.406
2016 Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. Proteome-wide covalent ligand discovery in native biological systems. Nature. PMID 27309814 DOI: 10.1038/Nature18002  0.543
2014 Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. The Journal of Biological Chemistry. 289: 25041-53. PMID 25028517 DOI: 10.1074/Jbc.M114.581579  0.529
2011 Barry CS, Backus KM, Barry CE, Davis BG. ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. Journal of the American Chemical Society. 133: 13232-5. PMID 21776980 DOI: 10.1021/Ja204249P  0.524
2011 Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE, Davis BG. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nature Chemical Biology. 7: 228-35. PMID 21378984 DOI: 10.1038/Nchembio.539  0.484
Low-probability matches (unlikely to be authored by this person)
2023 Yan T, Boatner LM, Cui L, Tontonoz PJ, Backus KM. Defining the Cell Surface Cysteinome Using Two-Step Enrichment Proteomics. Jacs Au. 3: 3506-3523. PMID 38155636 DOI: 10.1021/jacsau.3c00707  0.294
2021 Burton NR, Kim P, Backus KM. Photoaffinity labelling strategies for mapping the small molecule-protein interactome. Organic & Biomolecular Chemistry. 19: 7792-7809. PMID 34549230 DOI: 10.1039/d1ob01353j  0.291
2021 Raj M, Tang KC, Cao J, Boatner LM, Li L, Farhi J, Houk KN, Spangle J, Backus KM. Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angewandte Chemie (International Ed. in English). PMID 34762358 DOI: 10.1002/anie.202112107  0.284
2021 Julio AR, Backus KM. New approaches to target RNA binding proteins. Current Opinion in Chemical Biology. 62: 13-23. PMID 33535093 DOI: 10.1016/j.cbpa.2020.12.006  0.282
2021 Tang KC, Maddox SM, Backus KM, Raj M. Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling. Chemical Science. 13: 763-774. PMID 35173941 DOI: 10.1039/d1sc04139h  0.27
2021 Cao J, Boatner LM, Desai HS, Burton NR, Armenta E, Chan NJ, Castellón JO, Backus KM. Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Analytical Chemistry. PMID 33470097 DOI: 10.1021/acs.analchem.0c04726  0.27
2023 Desai H, Ofori S, Boatner L, Yu F, Villanueva M, Ung N, Nesvizhskii AI, Backus K. Multi-omic stratification of the missense variant cysteinome. Biorxiv : the Preprint Server For Biology. PMID 37645963 DOI: 10.1101/2023.08.12.553095  0.262
2023 Castellón JO, Ofori S, Armenta E, Burton N, Boatner LM, Takayoshi EE, Faragalla M, Zhou A, Tran K, Shek J, Yan T, Desai HS, Backus KM. Chemoproteomics identifies proteoform-selective caspase-2 inhibitors. Biorxiv : the Preprint Server For Biology. PMID 37961563 DOI: 10.1101/2023.10.25.563785  0.261
2022 Desai HS, Yan T, Yu F, Sun AW, Villanueva M, Nesvizhskii AI, Backus KM. SP3-enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State Dependent Redox-Sensitive Cysteines. Molecular & Cellular Proteomics : McP. 100218. PMID 35219905 DOI: 10.1016/j.mcpro.2022.100218  0.236
2023 Yan T, Julio AR, Villaneuva M, Jones AE, Ball AAB, Boatner LM, Turmon AC, Yen SL, Desai HS, Divakaruni AS, Backus KM. Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. Biorxiv : the Preprint Server For Biology. PMID 36711448 DOI: 10.1101/2023.01.22.525042  0.223
2021 Yan T, Desai HS, Boatner LM, Yen SL, Cao J, Palafox MF, Jami-Alahmadi Y, Backus K. SP3-FAIMS chemoproteomics for high coverage profiling of the human cysteinome. Chembiochem : a European Journal of Chemical Biology. PMID 33442901 DOI: 10.1002/cbic.202000870  0.216
2024 Julio AR, Yan T, Backus KM. Protocol for organelle-specific cysteine capture and quantification of cysteine oxidation state. Star Protocols. 5: 102865. PMID 38329879 DOI: 10.1016/j.xpro.2024.102865  0.211
2023 Yan T, Julio AR, Villanueva M, Jones AE, Ball AB, Boatner LM, Turmon AC, Nguyễn KB, Yen SL, Desai HS, Divakaruni AS, Backus KM. Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. Cell Chemical Biology. PMID 37419112 DOI: 10.1016/j.chembiol.2023.06.008  0.178
2023 Burton NR, Polasky DA, Shikwana F, Ofori S, Yan T, Geiszler DJ, Veiga Leprevost FD, Nesvizhskii AI, Backus KM. Solid-Phase Compatible Silane-Based Cleavable Linker Enables Custom Isobaric Quantitative Chemoproteomics. Journal of the American Chemical Society. PMID 37738129 DOI: 10.1021/jacs.3c05797  0.173
2022 Yan T, Palmer AB, Geiszler DJ, Polasky DA, Boatner LM, Burton NR, Armenta E, Nesvizhskii AI, Backus KM. Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Analytical Chemistry. PMID 35195394 DOI: 10.1021/acs.analchem.1c04402  0.166
2022 Desai HS, Yan T, Backus KM. SP3-FAIMS-Enabled High-Throughput Quantitative Profiling of the Cysteinome. Current Protocols. 2: e492. PMID 35895291 DOI: 10.1002/cpz1.492  0.155
2023 Boatner LM, Palafox MF, Schweppe DK, Backus KM. CysDB: a human cysteine database based on experimental quantitative chemoproteomics. Cell Chemical Biology. PMID 37119813 DOI: 10.1016/j.chembiol.2023.04.004  0.144
2024 Burton NR, Backus KM. Functionalizing tandem mass tags for streamlining click-based quantitative chemoproteomics. Communications Chemistry. 7: 80. PMID 38600184 DOI: 10.1038/s42004-024-01162-x  0.12
2022 Backus KM, Pan Z, Jones LH. Introduction to the themed collection on Covalent Drug Discovery. Rsc Medicinal Chemistry. 13: 893-894. PMID 36092145 DOI: 10.1039/d2md90022j  0.086
2021 Palafox MF, Desai HS, Arboleda VA, Backus KM. From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Molecular Systems Biology. 17: e9840. PMID 33599394 DOI: 10.15252/msb.20209840  0.067
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