| Year |
Citation |
Score |
| 2023 |
Schubert L, Le AT, Hinz TK, Navarro AC, Nelson-Taylor SK, Nemenoff RA, Heasley LE, Doebele RC. A Functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes. Biology Open. PMID 37470475 DOI: 10.1242/bio.059994 |
0.614 |
|
| 2023 |
Schubert L, Le AT, Hinz TK, Navarro A, Nelson-Taylor SK, Nemenoff RA, Heasley LE, Doebele RC. A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes. Biorxiv : the Preprint Server For Biology. PMID 37066347 DOI: 10.1101/2023.04.06.535912 |
0.614 |
|
| 2023 |
Sisler DJ, Hinz TK, Le AT, Kleczko EK, Nemenoff RA, Heasley LE. Evaluation of KRAS inhibitor responses in novel murine KRAS lung cancer cell line models. Frontiers in Oncology. 13: 1094123. PMID 36845684 DOI: 10.3389/fonc.2023.1094123 |
0.808 |
|
| 2023 |
Kleczko EK, Hinz TK, Nguyen TT, Gurule NJ, Navarro A, Le AT, Johnson AM, Kwak J, Polhac DI, Clambey ET, Weiser-Evans M, Merrick DT, Yang MC, Patil T, Schenk EL, ... Heasley LE, et al. Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. Npj Precision Oncology. 7: 15. PMID 36739466 DOI: 10.1038/s41698-023-00355-2 |
0.808 |
|
| 2023 |
Kleczko EK, Poczobutt JM, Navarro AC, Laskowski J, Johnson AM, Korpela SP, Gurule NJ, Heasley LE, Hopp K, Weiser-Evans MCM, Gottlin EB, Bushey RT, Campa MJ, Patz EF, Thurman JM, et al. Upregulation of complement proteins in lung cancer cells mediates tumor progression. Frontiers in Oncology. 12: 1045690. PMID 36686777 DOI: 10.3389/fonc.2022.1045690 |
0.805 |
|
| 2023 |
Kleczko EK, Le AT, Hinz TK, Nguyen TT, Navarro A, Hu CJ, Selman AM, Clambey ET, Merrick DT, Lu S, Weiser-Evans M, Nemenoff RA, Heasley LE. Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response. Cancer Letters. 216062. PMID 36657561 DOI: 10.1016/j.canlet.2023.216062 |
0.828 |
|
| 2022 |
Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S, Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, ... ... Heasley LE, et al. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. Nature Communications. 13: 3535. PMID 35725568 DOI: 10.1038/s41467-022-31124-7 |
0.318 |
|
| 2021 |
Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer cell-specific MHCII expression as a determinant of the immune infiltrate organization and function in the non-small cell lung cancer tumor microenvironment. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 34048945 DOI: 10.1016/j.jtho.2021.05.004 |
0.615 |
|
| 2021 |
Hinz TK, Kalkur R, Rabinovitch J, Hinkle W, Heasley LE. . Molecular Pharmacology. PMID 34031188 DOI: 10.1124/molpharm.121.000254 |
0.411 |
|
| 2021 |
Gurule NJ, McCoach CE, Hinz TK, Merrick DT, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff RA, Tan AC, Doebele RC, Heasley LE. A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer. Npj Precision Oncology. 5: 41. PMID 34001994 DOI: 10.1038/s41698-021-00181-4 |
0.755 |
|
| 2021 |
Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. Journal of Translational Medicine. 19: 43. PMID 33485341 DOI: 10.1186/s12967-021-02706-8 |
0.648 |
|
| 2020 |
Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. Journal For Immunotherapy of Cancer. 8. PMID 32312906 DOI: 10.1136/Jitc-2019-000441 |
0.799 |
|
| 2020 |
Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. Journal of Immunology (Baltimore, Md. : 1950). PMID 32179637 DOI: 10.4049/Jimmunol.1900778 |
0.647 |
|
| 2020 |
Sisler D, Korpela S, Gurule N, Hinz T, Marek L, Bullock B, Li H, Joshi M, Sempeck C, Nemenoff R, Heasley L. Abstract B51: MAPK regulation of an innate immune response in KRAS-mutant lung adenocarcinoma Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B51 |
0.694 |
|
| 2019 |
Hinz TK, Kleczko EK, Singleton KR, Calhoun J, Marek LA, Kim J, Tan AC, Heasley LE. Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines. Molecular Pharmacology. PMID 31554698 DOI: 10.1124/Mol.119.117804 |
0.837 |
|
| 2019 |
Hinz TK, Heasley LE. Translating mesothelioma molecular genomics and dependencies into precision oncology-based therapies. Seminars in Cancer Biology. PMID 31546009 DOI: 10.1016/J.Semcancer.2019.09.014 |
0.39 |
|
| 2019 |
Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Van Court B, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. The role of regulatory T cells in the response to radiation therapy in head and neck cancer. Journal of the National Cancer Institute. PMID 30863843 DOI: 10.1093/Jnci/Djz036 |
0.584 |
|
| 2019 |
Oweida A, Darragh L, Bhatia S, Raben D, Heasley L, Nemenoff R, Clambey E, Karam S. Regulatory T cells mediate resistance to radiotherapy in head and neck squamous cell carcinoma. Journal of Clinical Oncology. 37: 70-70. DOI: 10.1200/Jco.2019.37.8_Suppl.70 |
0.613 |
|
| 2018 |
Gurule NJ, Heasley LE. Linking tyrosine kinase inhibitor-mediated inflammation with normal epithelial cell homeostasis and tumor therapeutic responses. Cancer Drug Resistance (Alhambra, Calif.). 1: 118-125. PMID 30656289 DOI: 10.20517/cdr.2018.12 |
0.432 |
|
| 2018 |
Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin. Molecular Pharmacology. PMID 30404891 DOI: 10.1124/Mol.118.113159 |
0.611 |
|
| 2018 |
Ng TL, Yu H, Smith DE, Boyle TA, York ER, Leedy S, Gao D, Aisner DL, Van Bokhoven A, Heasley LE, Hirsch FR, Camidge DR. Preselection of Lung Cancer Cases Using FGFR1 mRNA and Gene Copy Number for Treatment With Ponatinib. Clinical Lung Cancer. PMID 30297175 DOI: 10.1200/Jco.2018.36.15_Suppl.12095 |
0.517 |
|
| 2018 |
Ren S, Rivard CJ, Yu H, Genova C, Rozenboom L, Gao D, Hinz TK, Rikke BA, Wynes MW, Caldwell C, Agustoni F, Kenichi Suda, Jiang T, Zhou C, Heasley LE, et al. A miRNA Panel Predicts Sensitivity of FGFR Inhibitor in Lung Cancer Cell Lines. Clinical Lung Cancer. 19: 450-456. PMID 30146263 DOI: 10.1016/J.Cllc.2018.06.004 |
0.439 |
|
| 2018 |
Oweida A, Hararah M, Phan AV, Binder DC, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey ET, et al. Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30042205 DOI: 10.1158/1078-0432.Ccr-18-1038 |
0.659 |
|
| 2018 |
Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, ... ... Heasley L, et al. Altered cell-cycle control, inflammation and adhesion in high-risk persistent bronchial dysplasia. Cancer Research. PMID 29997230 DOI: 10.1158/0008-5472.Can-17-3822 |
0.64 |
|
| 2018 |
Bhatia S, Griego A, Lennon S, Oweida A, Sharma J, Rohmer C, Uyanga N, Bukkapatnam S, Van Court B, Raben D, Young C, Heasley L, Karam SD. Role of EphB3 receptor in mediating head and neck tumor growth, cell migration, and response to PI3K inhibitor. Molecular Cancer Therapeutics. PMID 29970482 DOI: 10.1158/1535-7163.Mct-17-1163 |
0.488 |
|
| 2018 |
Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan AV, Milner D, Uyanga N, Jimeno A, Raben D, Somerset H, Heasley L, Karam SD. Inhibition of EphB4-ephrin-B2 signaling enhances response to Cetuximab-radiation therapy in head and neck cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29848571 DOI: 10.1158/1078-0432.Ccr-18-0327 |
0.369 |
|
| 2018 |
Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC. ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 9: 8823-8835. PMID 29507657 DOI: 10.18632/Oncotarget.24260 |
0.832 |
|
| 2018 |
Kleczko EK, Heasley LE. Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities. Molecular Cancer. 17: 60. PMID 29458371 DOI: 10.1186/S12943-018-0816-Y |
0.804 |
|
| 2018 |
Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Gill P, Jimeno A, Raben D, Heasley L, Karam SD. Abstract 4169: Inhibition of EphB4-ephrin-B2 signaling results in enhanced sensitivity to cetuximab-radiation therapy in head and neck cancers Tumor Biology. DOI: 10.1158/1538-7445.Am2018-4169 |
0.322 |
|
| 2018 |
Oweida AJ, Hararah M, Phan A, Bhatia S, Lennon S, Binder D, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Abstract 2766: Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation in anti-PD-L1 refractory head and neck cancer Cancer Research. 78: 2766-2766. DOI: 10.1158/1538-7445.Am2018-2766 |
0.579 |
|
| 2017 |
Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 6: e1356153. PMID 29123967 DOI: 10.1080/2162402X.2017.1356153 |
0.57 |
|
| 2017 |
Li HY, McSharry MV, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PDL1 Antibody Blockade. Cancer Immunology Research. PMID 28819064 DOI: 10.1158/2326-6066.Cir-16-0365 |
0.615 |
|
| 2017 |
Singleton KR, Earley KT, Heasley LE. Analysis of Drug Resistance Using Kinome-Wide Functional Screens. Methods in Molecular Biology (Clifton, N.J.). 1636: 163-177. PMID 28730479 DOI: 10.1007/978-1-4939-7154-1_11 |
0.782 |
|
| 2017 |
Suda K, Rozeboom L, Rivard CJ, Yu H, Ellison K, Melnick MAC, Hinz TK, Chan D, Heasley LE, Politi K, Mitsudomi T, Hirsch FR. Therapy-induced E-cadherin downregulation alters expression of programmed death ligand-1 in lung cancer cells. Lung Cancer (Amsterdam, Netherlands). 109: 1-8. PMID 28577937 DOI: 10.1016/J.Lungcan.2017.04.010 |
0.473 |
|
| 2017 |
Vaishnavi A, Schubert L, Rix U, Marek LA, Le AT, Keysar S, Glogowska MJ, Smith MA, Kako SL, Sumi NJ, Davies KD, Ware KE, Varella-Garcia M, Haura EB, Jimeno A, ... Heasley LE, et al. EGFR mediates responses to small molecule drugs targeting oncogenic fusion kinases. Cancer Research. PMID 28428274 DOI: 10.1158/0008-5472.Can-17-0109 |
0.828 |
|
| 2017 |
Ohm AM, Tan AC, Heasley LE, Reyland ME. Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. Oncogene. PMID 28368426 DOI: 10.1038/Onc.2017.27 |
0.608 |
|
| 2017 |
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 6: e287. PMID 28092369 DOI: 10.1038/oncsis.2016.89 |
0.593 |
|
| 2017 |
Oweida A, Lennon S, Calame D, Bhatia S, Raben D, Heasley L, Nemenoff R, Karam S. Radiotherapy to enhance T-cell infiltration and efficacy of PD-L1 blockade in murine orthotopic models of head and neck cancer. Journal of Clinical Oncology. 35: 101-101. DOI: 10.1200/Jco.2017.35.7_Suppl.101 |
0.566 |
|
| 2017 |
Ng T, Yu H, York E, Leedy S, Gao D, Heasley L, Hirsch F, Camidge D. P2.02-011 Clinical and Molecular Features of Lung Cancers with Increased FGFR1 mRNA and/or Gene Copy Number Journal of Thoracic Oncology. 12: S2102. DOI: 10.1016/J.Jtho.2017.09.1188 |
0.354 |
|
| 2017 |
McCoach C, Merrick D, Aisner D, Bunn P, Camdige D, Heasley L, Doebele R. Targeting Residual Disease in Oncogene-Driven NSCLC Journal of Thoracic Oncology. 12: S1546. DOI: 10.1016/J.Jtho.2017.06.064 |
0.325 |
|
| 2017 |
Suda K, Rozeboom L, Rivard C, Yu H, Melnick MA, Hinz T, Ellison K, Chan D, Politi K, Heasley L, Mitsudomi T, Hirsch FR. MA15.11 Acquired Resistance Mechanisms to EGFR Kinase Inhibitors Alter PD-L1 Expression Status in Lung Cancer Journal of Thoracic Oncology. 12: S433-S434. DOI: 10.1016/J.Jtho.2016.11.505 |
0.478 |
|
| 2017 |
Helfrich B, Scarborough H, Heasley L, Ryall K, Tan A, Degregori J, Bunn P. P3.02b-084 Rational Combinations to Improve Outcome for EGFR-TKIs in NSCLCs with EGFR Mutations Journal of Thoracic Oncology. 12: S1242. DOI: 10.1016/J.Jtho.2016.11.1751 |
0.586 |
|
| 2017 |
Oweida A, Calame D, Lennon S, Bhatia S, Raben D, Clambey E, Heasley L, Nemenoff R, Karam S. Radiotherapy Sensitizes Head and Neck Tumors to PD-L1 Immune Checkpoint Blockade International Journal of Radiation Oncology*Biology*Physics. 99: S202. DOI: 10.1016/j.ijrobp.2017.06.501 |
0.486 |
|
| 2016 |
Nakachi I, Helfrich BA, Spillman MA, Mickler EA, Olson CJ, Rice JL, Coldren CD, Heasley LE, Geraci MW, Stearman RS. PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines. Clinical and Translational Science. 9: 293-301. PMID 27766744 DOI: 10.1111/Cts.12413 |
0.496 |
|
| 2016 |
von Mässenhausen A, Sanders C, Thewes B, Deng M, Queisser A, Vogel W, Kristiansen G, Duensing S, Schröck A, Bootz F, Brossart P, Kirfel J, Heasley L, Brägelmann J, Perner S. MERTK as a novel therapeutic target in head and neck cancer. Oncotarget. PMID 27081701 DOI: 10.18632/Oncotarget.8724 |
0.412 |
|
| 2016 |
von Mässenhausen A, Deng M, Billig H, Queisser A, Vogel W, Kristiansen G, Schröck A, Bootz F, Göke F, Franzen A, Heasley L, Kirfel J, Brägelmann J, Perner S. Evaluation of FGFR3 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma. Targeted Oncology. PMID 27053219 DOI: 10.1007/S11523-016-0431-Z |
0.377 |
|
| 2015 |
Ryall KA, Kim J, Klauck PJ, Shin J, Yoo M, Ionkina A, Pitts TM, Tentler JJ, Diamond JR, Eckhardt S, Heasley LE, Kang J, Tan AC. An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer. Bmc Genomics. 16: S2. PMID 26681397 DOI: 10.1186/1471-2164-16-S12-S2 |
0.623 |
|
| 2015 |
Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser WJ, Kennedy TC, Blatchford P, Braudrick S, Hirsch FR, Heasley LE, Bunn PA, Franklin WA. PERSISTENCE OF BRONCHIAL DYSPLASIA IS ASSOCIATED WITH DEVELOPMENT OF INVASIVE SQUAMOUS CELL CARCINOMA. Cancer Prevention Research (Philadelphia, Pa.). PMID 26542061 DOI: 10.1158/1940-6207.Capr-15-0305 |
0.344 |
|
| 2015 |
Singleton KR, Hinz TK, Kleczko EK, Marek LA, Kwak J, Harp T, Kim J, Tan AC, Heasley LE. Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. Cancer Research. 75: 4398-406. PMID 26359452 DOI: 10.1158/0008-5472.Can-15-0509 |
0.843 |
|
| 2015 |
Ryall KA, Shin J, Yoo M, Hinz TK, Kim J, Kang J, Heasley LE, Tan AC. Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data. Bioinformatics (Oxford, England). PMID 26206305 DOI: 10.1093/Bioinformatics/Btv427 |
0.634 |
|
| 2015 |
Zhang L, Yu H, Badzio A, Boyle TA, Schildhaus HU, Lu X, Dziadziuszko R, Jassem J, Varella-Garcia M, Heasley LE, Kowalewski AA, Ellison K, Chen G, Zhou C, Hirsch FR. Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 10: 1083-90. PMID 26020126 DOI: 10.1097/Jto.0000000000000562 |
0.427 |
|
| 2015 |
Göke F, Franzen A, Hinz TK, Marek LA, Yoon P, Sharma R, Bode M, von Mässenhausen A, Lankat-Buttgereit B, Göke A, Golletz C, Kirsten R, Boehm D, Vogel W, Kleczko EK, ... ... Heasley LE, et al. FGFR1 expression levels predict BGJ398-sensitivity of FGFR1-dependent head and neck squamous cell cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26015511 DOI: 10.1158/1078-0432.Ccr-14-3357 |
0.815 |
|
| 2015 |
Kleczko EK, Kim J, Keysar SB, Heasley LR, Eagles JR, Simon M, Marshall ME, Singleton KR, Jimeno A, Tan AC, Heasley LE. An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. Plos One. 10: e0123600. PMID 25946135 DOI: 10.1371/Journal.Pone.0123600 |
0.829 |
|
| 2014 |
Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE. Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma. Molecular Cancer Research : McR. 12: 1460-9. PMID 24966347 DOI: 10.1158/1541-7786.Mcr-14-0038 |
0.849 |
|
| 2014 |
Sena JA, Wang L, Heasley LE, Hu CJ. Hypoxia regulates alternative splicing of HIF and non-HIF target genes. Molecular Cancer Research : McR. 12: 1233-43. PMID 24850901 DOI: 10.1158/1541-7786.Mcr-14-0149 |
0.327 |
|
| 2014 |
Kim J, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC. Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. Bioinformatics (Oxford, England). 30: 2393-8. PMID 24812339 DOI: 10.1093/Bioinformatics/Btu323 |
0.84 |
|
| 2014 |
Wynes MW, Hinz TK, Gao D, Martini M, Marek LA, Ware KE, Edwards MG, Böhm D, Perner S, Helfrich BA, Dziadziuszko R, Jassem J, Wojtylak S, Sejda A, Gozgit JM, ... ... Heasley LE, et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 3299-309. PMID 24771645 DOI: 10.1158/1078-0432.CCR-13-3060 |
0.819 |
|
| 2014 |
Schröck A, Bode M, Göke FJ, Bareiss PM, Schairer R, Wang H, Weichert W, Franzen A, Kirsten R, van Bremen T, Queisser A, Kristiansen G, Heasley L, Bootz F, Lengerke C, et al. Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma. Carcinogenesis. 35: 1636-42. PMID 24743512 DOI: 10.1093/Carcin/Bgu094 |
0.433 |
|
| 2014 |
Merrick DT, Edwards MG, Franklin WA, Sugita M, Friedman M, Miller YE, Dwyer-Nield L, Tennis M, Choo K, Hickey G, Adriaan vB, Heasley L, Bunn PA, Geraci M, Keith RL, et al. Abstract 231: Gene expression analysis of persistent and regressive bronchial dysplasia identifies polo-like kinase 1 (PLK1) and epoxide hydrolase 3 (EPHX3) as potential mediators of malignant progression Cancer Research. 74: 231-231. DOI: 10.1158/1538-7445.Am2014-231 |
0.621 |
|
| 2014 |
Newton TP, Cummings CT, Kirkpatrick GD, Hinz TK, DeRyckere D, Zhang W, Wang X, Frye S, Earp HS, Heasley L, Graham DK. Abstract 1736: A novel Mer tyrosine kinase inhibitor mediates increased cell killing in combination with FGFR inhibition Cancer Research. 74: 1736-1736. DOI: 10.1158/1538-7445.Am2014-1736 |
0.574 |
|
| 2013 |
von Mässenhausen A, Franzen A, Heasley L, Perner S. FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area. Annals of Translational Medicine. 1: 23. PMID 25332967 DOI: 10.3978/J.Issn.2305-5839.2013.06.08 |
0.434 |
|
| 2013 |
Davies KD, Mahale S, Astling DP, Aisner DL, Le AT, Hinz TK, Vaishnavi A, Bunn PA, Heasley LE, Tan AC, Camidge DR, Varella-Garcia M, Doebele RC. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. Plos One. 8: e82236. PMID 24349229 DOI: 10.1371/Journal.Pone.0082236 |
0.692 |
|
| 2013 |
Avasarala S, Bikkavilli RK, Van Scoyk M, Zhang W, Lapite A, Hostetter L, Byers JT, Heasley LE, Sohn JW, Winn RA. Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer. Plos One. 8: e76895. PMID 24204697 DOI: 10.1371/Journal.Pone.0076895 |
0.544 |
|
| 2013 |
Göke F, Göke A, von Mässenhausen A, Franzen A, Sharma R, Kirsten R, Böhm D, Kristiansen G, Stenzinger A, Wynes M, Hirsch FR, Weichert W, Heasley L, Buettner R, Perner S. Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer. Digestion. 88: 172-81. PMID 24135816 DOI: 10.1159/000355018 |
0.4 |
|
| 2013 |
Göke F, Bode M, Franzen A, Kirsten R, Goltz D, Göke A, Sharma R, Boehm D, Vogel W, Wagner P, Lengerke C, Kristiansen G, Kirfel J, Van Bremen T, Bootz F, ... Heasley LE, et al. Fibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neck. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 26: 1298-306. PMID 23619603 DOI: 10.1038/Modpathol.2013.58 |
0.441 |
|
| 2013 |
Ware KE, Hinz TK, Kleczko E, Singleton KR, Marek LA, Helfrich BA, Cummings CT, Graham DK, Astling D, Tan AC, Heasley LE. A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop. Oncogenesis. 2: e39. PMID 23552882 DOI: 10.1038/oncsis.2013.4 |
0.827 |
|
| 2013 |
Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Molecular Pharmacology. 83: 882-93. PMID 23371912 DOI: 10.1124/Mol.112.084111 |
0.838 |
|
| 2013 |
Linger RM, Cohen RA, Cummings CT, Sather S, Migdall-Wilson J, Middleton DH, Lu X, Barón AE, Franklin WA, Merrick DT, Jedlicka P, DeRyckere D, Heasley LE, Graham DK. Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene. 32: 3420-31. PMID 22890323 DOI: 10.1038/Onc.2012.355 |
0.562 |
|
| 2013 |
Kleczko EK, Heasley LR, Marshall ME, Singleton KR, Heasley LE. Abstract 3387: Tyrosine kinase inhibitors induce TGF-β2 expression in head and neck squamous cell carcinoma cell lines as a mechanism of acquired resistance. Cancer Research. 73: 3387-3387. DOI: 10.1158/1538-7445.Am2013-3387 |
0.783 |
|
| 2012 |
Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, Kondo KL, Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 1472-82. PMID 22235099 DOI: 10.1158/1078-0432.Ccr-11-2906 |
0.477 |
|
| 2012 |
Kono SA, Heasley LE, Doebele RC, Camidge DR. Adding to the mix: fibroblast growth factor and platelet-derived growth factor receptor pathways as targets in non-small cell lung cancer. Current Cancer Drug Targets. 12: 107-23. PMID 22165970 DOI: 10.2174/156800912799095144 |
0.481 |
|
| 2012 |
Pilling AB, Le AT, Tan A, Kim J, Singleton KR, Heasley LE, Helfrich B, DeGregori J, Doebele RC. Abstract 5594: ALK-driven lung cancer: Potential therapeutic strategies for treatment and prevention of drug resistance Cancer Research. 72: 5594-5594. DOI: 10.1158/1538-7445.Am2012-5594 |
0.682 |
|
| 2012 |
Singleton KR, Tan A, Kim J, Heasley L. Abstract B35: Alternate receptor tyrosine kinases provide protection from FGFR inhibition in HNSCC cells as identified by genome-wide shRNA screening Clinical Cancer Research. 18: B35-B35. DOI: 10.1158/1078-0432.Mechres-B35 |
0.852 |
|
| 2012 |
Kleczko EK, Heasley L, Heasley LE. Abstract B29: TGF- 2 induction in head and neck squamous cell carcinoma cell lines upon treatment with tyrosine kinase inhibitors as a mechanism of acquired resistance Clinical Cancer Research. 18: B29-B29. DOI: 10.1158/1078-0432.Mechres-B29 |
0.809 |
|
| 2011 |
Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, Marek L, Frederick BA, Raben D, Heasley LE. Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5016-25. PMID 21673064 DOI: 10.1158/1078-0432.Ccr-11-0050 |
0.814 |
|
| 2011 |
Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME. Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors. Cancer Research. 71: 2087-97. PMID 21335545 DOI: 10.1158/0008-5472.Can-10-1511 |
0.439 |
|
| 2011 |
Ware KE, Heasley LE. Abstract B70: Participation of fibroblast growth factor receptors (FGFRs) in acquired resistance to EGFR-specific TKIs in NSCLC. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B70 |
0.566 |
|
| 2010 |
Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P, Helfrich BA, Doebele RC, Heasley LE. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. Plos One. 5: e14117. PMID 21152424 DOI: 10.1371/Journal.Pone.0014117 |
0.82 |
|
| 2010 |
Chen P, O'Neal JF, Ebelt ND, Cantrell MA, Mitra S, Nasrazadani A, Vandenbroek TL, Heasley LE, Van Den Berg CL. Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. Plos One. 5: e10443. PMID 20454618 DOI: 10.1371/Journal.Pone.0010443 |
0.348 |
|
| 2010 |
Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia (New York, N.Y.). 12: 244-53. PMID 20234818 DOI: 10.1593/Neo.91690 |
0.708 |
|
| 2009 |
Kono SA, Marshall ME, Ware KE, Heasley LE. The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 12: 95-102. PMID 19501013 DOI: 10.1016/J.Drup.2009.05.001 |
0.818 |
|
| 2009 |
Wang XQ, Li H, Van Putten V, Winn RA, Heasley LE, Nemenoff RA. Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Molecular Biology of the Cell. 20: 791-800. PMID 19037103 DOI: 10.1091/Mbc.E08-07-0732 |
0.644 |
|
| 2009 |
Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA, Heasley LE. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Molecular Pharmacology. 75: 196-207. PMID 18849352 DOI: 10.1124/Mol.108.049544 |
0.846 |
|
| 2008 |
Heasley LE, Winn RA. Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells. Methods in Molecular Biology (Clifton, N.J.). 468: 187-96. PMID 19099255 DOI: 10.1007/978-1-59745-249-6_14 |
0.509 |
|
| 2008 |
Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. Molecular Pharmacology. 73: 709-17. PMID 18055759 DOI: 10.1124/Mol.107.042002 |
0.696 |
|
| 2007 |
Binétruy B, Heasley L, Bost F, Caron L, Aouadi M. Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases. Stem Cells (Dayton, Ohio). 25: 1090-5. PMID 17218395 DOI: 10.1634/Stemcells.2006-0612 |
0.415 |
|
| 2007 |
Helfich B, Bunn PA, McDermott LA, Heasley L. A5-07: FGF2 and FGFRs comprise an auxiliary autocrine pathway in NSCLC cell lines Journal of Thoracic Oncology. 2: S325. DOI: 10.1097/01.Jto.0000283124.67530.E1 |
0.395 |
|
| 2006 |
Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA. Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. The Journal of Biological Chemistry. 281: 26943-50. PMID 16835228 DOI: 10.1074/Jbc.M604145200 |
0.662 |
|
| 2006 |
Heasley LE, Han SY. JNK regulation of oncogenesis. Molecules and Cells. 21: 167-73. PMID 16682809 |
0.692 |
|
| 2005 |
Amura CR, Marek L, Winn RA, Heasley LE. Inhibited neurogenesis in JNK1-deficient embryonic stem cells. Molecular and Cellular Biology. 25: 10791-802. PMID 16314504 DOI: 10.1128/Mcb.25.24.10791-10802.2005 |
0.395 |
|
| 2005 |
Abell AN, Rivera-Perez JA, Cuevas BD, Uhlik MT, Sather S, Johnson NL, Minton SK, Lauder JM, Winter-Vann AM, Nakamura K, Magnuson T, Vaillancourt RR, Heasley LE, Johnson GL. Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Molecular and Cellular Biology. 25: 8948-59. PMID 16199873 DOI: 10.1128/Mcb.25.20.8948-8959.2005 |
0.563 |
|
| 2005 |
Takada E, Shimo K, Hata K, Abiake M, Mukai Y, Moriyama M, Heasley L, Mizuguchi J. Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells. Experimental Cell Research. 304: 518-30. PMID 15748896 DOI: 10.1016/J.Yexcr.2004.11.015 |
0.32 |
|
| 2005 |
Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. The Journal of Biological Chemistry. 280: 19625-34. PMID 15705594 DOI: 10.1074/Jbc.M409392200 |
0.787 |
|
| 2004 |
Marek L, Levresse V, Amura C, Zentrich E, Van Putten V, Nemenoff RA, Heasley LE. Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells. Journal of Cellular Physiology. 201: 459-69. PMID 15389548 DOI: 10.1002/Jcp.20087 |
0.638 |
|
| 2004 |
Winn RA, Heasley LE. Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. Chest. 125: 122S-3S. PMID 15136458 DOI: 10.1378/chest.125.5_suppl.122S |
0.375 |
|
| 2004 |
Heasley LE, Petersen BE. Signalling in stem cells: meeting on signal transduction determining the fate of stem cells. Embo Reports. 5: 241-4. PMID 14978509 DOI: 10.1038/Sj.Embor.7400098 |
0.376 |
|
| 2002 |
Wick M, Hurteau G, Dessev C, Chan D, Geraci MW, Winn RA, Heasley LE, Nemenoff RA. Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth. Molecular Pharmacology. 62: 1207-14. PMID 12391285 DOI: 10.1124/Mol.62.5.1207 |
0.7 |
|
| 2002 |
Winn RA, Bremnes RM, Bemis L, Franklin WA, Miller YE, Cool C, Heasley LE. gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth. Oncogene. 21: 7497-506. PMID 12386812 DOI: 10.1038/Sj.Onc.1205963 |
0.497 |
|
| 2002 |
Han SY, Kim SH, Heasley LE. Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts. The Journal of Biological Chemistry. 277: 47167-74. PMID 12354774 DOI: 10.1074/Jbc.M204270200 |
0.68 |
|
| 2002 |
Levresse V, Marek L, Blumberg D, Heasley LE. Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. Molecular Pharmacology. 62: 689-97. PMID 12181446 DOI: 10.1124/Mol.62.3.689 |
0.449 |
|
| 2002 |
Zentrich E, Han SY, Pessoa-Brandao L, Butterfield L, Heasley LE. Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cells. The Journal of Biological Chemistry. 277: 4110-8. PMID 11733514 DOI: 10.1074/Jbc.M107824200 |
0.689 |
|
| 2001 |
Heasley LE. Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene. 20: 1563-9. PMID 11313903 DOI: 10.1038/Sj.Onc.1204183 |
0.471 |
|
| 2001 |
Dreskin SC, Thomas GW, Dale SN, Heasley LE. Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 5646-53. PMID 11313405 DOI: 10.4049/Jimmunol.166.9.5646 |
0.365 |
|
| 2001 |
Van Putten V, Refaat Z, Dessev C, Blaine S, Wick M, Butterfield L, Han SY, Heasley LE, Nemenoff RA. Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells. The Journal of Biological Chemistry. 276: 1226-32. PMID 11042196 DOI: 10.1074/Jbc.M003581200 |
0.752 |
|
| 2000 |
Levresse V, Butterfield L, Zentrich E, Heasley LE. Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells. Journal of Neuroscience Research. 62: 799-808. PMID 11107164 DOI: 10.1002/1097-4547(20001215)62:6<799::Aid-Jnr6>3.0.Co;2-1 |
0.479 |
|
| 2000 |
Schwertfeger KL, Hunter S, Heasley LE, Levresse V, Leon RP, DeGregori J, Anderson SM. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). Molecular Endocrinology (Baltimore, Md.). 14: 1592-602. PMID 11043575 DOI: 10.1210/Mend.14.10.0536 |
0.429 |
|
| 2000 |
Zhang TT, Gealy R, Lu X, Heasley LE, Takimoto K, Levitan ES. TRH regulates Kv1.5 gene expression through a Galphaq-mediated PLC-independent pathway. Molecular and Cellular Endocrinology. 165: 33-9. PMID 10940481 DOI: 10.1016/S0303-7207(00)00268-9 |
0.338 |
|
| 2000 |
Yang T, Huang Y, Heasley LE, Berl T, Schnermann JB, Briggs JP. MAPK mediation of hypertonicity-stimulated cyclooxygenase-2 expression in renal medullary collecting duct cells. The Journal of Biological Chemistry. 275: 23281-6. PMID 10930430 DOI: 10.1074/Jbc.M910237199 |
0.439 |
|
| 2000 |
Bunn PA, Soriano A, Johnson G, Heasley L. New therapeutic strategies for lung cancer: biology and molecular biology come of age. Chest. 117: 163S-168S. PMID 10777473 DOI: 10.1378/Chest.117.4_Suppl_1.163S |
0.459 |
|
| 2000 |
Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. The Journal of Biological Chemistry. 275: 10761-6. PMID 10753867 DOI: 10.1074/Jbc.275.15.10761 |
0.459 |
|
| 1999 |
BUTTERFIELD L, ZENTRICH E, BEEKMAN A, HEASLEY LE. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms Biochemical Journal. 338: 681-686. DOI: 10.1042/Bj3380681 |
0.461 |
|
| 1998 |
Wojtaszek PA, Heasley LE, Berl T. In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction. The Journal of Clinical Investigation. 102: 1874-81. PMID 9819374 DOI: 10.1172/Jci4384 |
0.354 |
|
| 1998 |
Wojtaszek PA, Heasley LE, Siriwardana G, Berl T. Dominant-negative c-Jun NH2-terminal kinase 2 sensitizes renal inner medullary collecting duct cells to hypertonicity-induced lethality independent of organic osmolyte transport. The Journal of Biological Chemistry. 273: 800-4. PMID 9422734 DOI: 10.1074/Jbc.273.2.800 |
0.423 |
|
| 1997 |
Li X, Van Putten V, Zarinetchi F, Nicks ME, Thaler S, Heasley LE, Nemenoff RA. Suppression of smooth-muscle alpha-actin expression by platelet-derived growth factor in vascular smooth-muscle cells involves Ras and cytosolic phospholipase A2. The Biochemical Journal. 327: 709-16. PMID 9581546 DOI: 10.1042/bj3270709 |
0.544 |
|
| 1997 |
Higashita R, Li L, Van Putten V, Yamamura Y, Zarinetchi F, Heasley L, Nemenoff RA. Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway. The Journal of Biological Chemistry. 272: 25845-50. PMID 9325315 DOI: 10.1074/Jbc.272.41.25845 |
0.601 |
|
| 1997 |
Heasley LE, Thaler S, Nicks M, Price B, Skorecki K, Nemenoff RA. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. The Journal of Biological Chemistry. 272: 14501-4. PMID 9169405 DOI: 10.1074/Jbc.272.23.14501 |
0.634 |
|
| 1997 |
Butterfield L, Storey B, Maas L, Heasley LE. c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation. The Journal of Biological Chemistry. 272: 10110-6. PMID 9092556 DOI: 10.1074/Jbc.272.15.10110 |
0.451 |
|
| 1997 |
Berl T, Siriwardana G, Ao L, Butterfield LM, Heasley LE. Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells. The American Journal of Physiology. 272: F305-11. PMID 9087672 DOI: 10.1152/Ajprenal.1997.272.3.F305 |
0.456 |
|
| 1997 |
Fanger GR, Vaillancourt RR, Heasley LE, Montmayeur JP, Johnson GL, Maue RA. Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation. Molecular and Cellular Biology. 17: 89-99. PMID 8972189 DOI: 10.1128/Mcb.17.1.89 |
0.38 |
|
| 1997 |
Butterfield L, Storey B, Maas L, Heasley L. 583 cJun N-terminal kinase (JNK)-regulation of the apoptotic response of small cell lung cancer (SCLC) to ultraviolet (UV) radiation Lung Cancer. 18: 150. DOI: 10.1016/S0169-5002(97)89963-1 |
0.454 |
|
| 1997 |
Thaler S, Heasley L, Price B, Nicks M, Nemenoff R. 563 Induction of cytosolic phospholipase A2 by oncogenic RAS in human non-small cell lung cancer Lung Cancer. 18: 145. DOI: 10.1016/S0169-5002(97)89943-6 |
0.613 |
|
| 1997 |
Bunn P, Chan D, Johnson G, Heasley L, Stewart J, Gera L, Brenner D, Helfrich B. Anti-growth factor therapy for lung cancer Lung Cancer. 18: 10-11. DOI: 10.1016/S0169-5002(97)83860-3 |
0.577 |
|
| 1996 |
Ginès P, Li X, Brown SE, Nakamura T, Guzelian PS, Heasley LE, Schrier RW, Nemenoff RA. Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes. Hepatology (Baltimore, Md.). 23: 1167-73. PMID 8621150 DOI: 10.1002/Hep.510230535 |
0.624 |
|
| 1996 |
Heasley LE, Storey B, Fanger GR, Butterfield L, Zamarripa J, Blumberg D, Maue RA. GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases. Molecular and Cellular Biology. 16: 648-56. PMID 8552093 DOI: 10.1128/Mcb.16.2.648 |
0.382 |
|
| 1996 |
Heasley LE, Zamarripa J, Storey B, Helfrich B, Mitchell FM, Bunn PA, Johnson GL. Discordant signal transduction and growth inhibition of small cell lung carcinomas induced by expression of GTPase-deficient G alpha 16. The Journal of Biological Chemistry. 271: 349-54. PMID 8550585 DOI: 10.1074/Jbc.271.1.349 |
0.62 |
|
| 1995 |
Dhanasekaran N, Heasley LE, Johnson GL. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocrine Reviews. 16: 259-70. PMID 7671848 DOI: 10.1210/Edrv-16-3-259 |
0.515 |
|
| 1995 |
Prasad MV, Dermott JM, Heasley LE, Johnson GL, Dhanasekaran N. Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13. The Journal of Biological Chemistry. 270: 18655-9. PMID 7629196 DOI: 10.1074/Jbc.270.31.18655 |
0.494 |
|
| 1995 |
Wong R, Heasley L, Ao L, Berl T. Expression of GTPase-deficient Ras inhibits vasopressin signaling in cultured cortical collecting duct cells. The Journal of Clinical Investigation. 96: 597-601. PMID 7615832 DOI: 10.1172/Jci118072 |
0.381 |
|
| 1995 |
Ginès P, Li X, Zamarripa JL, Brown SE, Wieder ED, Nakamura T, Guzelian PS, Schrier RW, Heasley LE, Nemenoff RA. Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology (Baltimore, Md.). 22: 1296-303. PMID 7557884 DOI: 10.1016/0270-9139(95)90642-8 |
0.582 |
|
| 1995 |
Vaillancourt RR, Heasley LE, Zamarripa J, Storey B, Valius M, Kazlauskas A, Johnson GL. Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Molecular and Cellular Biology. 15: 3644-53. PMID 7540718 DOI: 10.1128/Mcb.15.7.3644 |
0.606 |
|
| 1995 |
Mitchell FM, Heasley LE, Qian NX, Zamarripa J, Johnson GL. Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P. The Journal of Biological Chemistry. 270: 8623-8. PMID 7536738 DOI: 10.1074/Jbc.270.15.8623 |
0.534 |
|
| 1995 |
Ginès P, Li X, Zamarripa JL, Brown SES, Wieder ED, Nakamura T, Guzelian PS, Schrier RW, Heasley LE, Nemenoff RA. Tyrosine kinase growth factor receptors but not seven-membrane–spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes Hepatology. 22: 1296-1303. DOI: 10.1016/0270-9139(95)90642-8 |
0.625 |
|
| 1994 |
Heasley LE, Senkfor SI, Winitz S, Strasheim A, Teitelbaum I, Berl T. Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells. The American Journal of Physiology. 267: F366-73. PMID 8092250 DOI: 10.1152/Ajprenal.1994.267.3.F366 |
0.389 |
|
| 1992 |
Abdel-Hafiz HA, Heasley LE, Kyriakis JM, Avruch J, Kroll DJ, Johnson GL, Hoeffler JP. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Molecular Endocrinology (Baltimore, Md.). 6: 2079-89. PMID 1337144 DOI: 10.1210/Mend.6.12.1337144 |
0.526 |
|
| 1992 |
Gallego C, Gupta SK, Heasley LE, Qian NX, Johnson GL. Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 7355-9. PMID 1323832 DOI: 10.1073/Pnas.89.16.7355 |
0.622 |
|
| 1992 |
Heasley LE, Johnson GL. The beta-PDGF receptor induces neuronal differentiation of PC12 cells. Molecular Biology of the Cell. 3: 545-53. PMID 1319243 DOI: 10.1091/Mbc.3.5.545 |
0.603 |
|
| 1991 |
Heasley LE, Benedict S, Gleavy J, Johnson GL. Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiation. Cell Regulation. 2: 479-89. PMID 1832020 DOI: 10.1091/Mbc.2.6.479 |
0.536 |
|
| 1991 |
Gupta SK, Dhanasekaran N, Heasley LE, Johnson GL. Activating mutations in the NH2- and COOH-terminal moieties of the Gs alpha subunit have dominant phenotypes and distinguishable kinetics of adenylyl cyclase stimulation. Journal of Cellular Biochemistry. 47: 359-68. PMID 1665495 DOI: 10.1002/Jcb.240470410 |
0.469 |
|
| 1990 |
Gupta SK, Diez E, Heasley LE, Osawa S, Johnson GL. A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2. Science (New York, N.Y.). 249: 662-6. PMID 2166341 DOI: 10.1126/Science.2166341 |
0.473 |
|
| 1990 |
Osawa S, Heasley LE, Dhanasekaran N, Gupta SK, Woon CW, Berlot C, Johnson GL. Mutation of the Gs protein alpha subunit NH2 terminus relieves an attenuator function, resulting in constitutive adenylyl cyclase stimulation. Molecular and Cellular Biology. 10: 2931-40. PMID 1692962 DOI: 10.1128/Mcb.10.6.2931 |
0.466 |
|
| 1989 |
Woon CW, Heasley L, Osawa S, Johnson GL. Mutation of glycine 49 to valine in the alpha subunit of GS results in the constitutive elevation of cyclic AMP synthesis. Biochemistry. 28: 4547-51. PMID 2548581 DOI: 10.1021/Bi00437A006 |
0.521 |
|
| 1988 |
Weiss ER, Kelleher DJ, Woon CW, Soparkar S, Osawa S, Heasley LE, Johnson GL. Receptor activation of G proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2841-8. PMID 3139484 DOI: 10.1096/Fasebj.2.13.3139484 |
0.479 |
|
| 1988 |
Brunton LL, Heasley LE. cAMP export and its regulation by prostaglandin A1. Methods in Enzymology. 159: 83-93. PMID 2842644 DOI: 10.1016/0076-6879(88)59010-9 |
0.65 |
|
| 1984 |
Brunton L, Heasley L, Azari J. Inhibitio of cyclic amp export avian red cells by PGA1 Prostaglandins. 27: 106. DOI: 10.1016/0090-6980(84)90351-4 |
0.634 |
|
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