| Year |
Citation |
Score |
| 2019 |
Ikonomov OC, Sbrissa D, Shisheva A. Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations. Toxicology and Applied Pharmacology. 114771. PMID 31628917 DOI: 10.1016/J.Taap.2019.114771 |
0.35 |
|
| 2019 |
Shisheva A, Sbrissa D, Hu B, Li J. Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J. Molecular Neurobiology. PMID 31313076 DOI: 10.1007/S12035-019-01693-8 |
0.396 |
|
| 2018 |
Sbrissa D, Naisan G, Ikonomov OC, Shisheva A. Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. Plos One. 13: e0204532. PMID 30240452 DOI: 10.1371/Journal.Pone.0204532 |
0.46 |
|
| 2018 |
Sbrissa D, Semaan L, Govindarajan B, Li Y, Caruthers NJ, Stemmer PM, Cher ML, Sethi S, Vaishampayan U, Shisheva A, Chinni SR. A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells. Oncogene. PMID 30111818 DOI: 10.1038/S41388-018-0448-0 |
0.352 |
|
| 2018 |
Ikonomov OC, Altankov G, Sbrissa D, Shisheva A. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and Applied Pharmacology. 356: 151-158. PMID 30098992 DOI: 10.1016/J.Taap.2018.08.001 |
0.379 |
|
| 2016 |
Tisdale EJ, Talati NK, Artalejo CR, Shisheva A. GAPDH binds Akt to facilitate cargo transport in the early secretory pathway. Experimental Cell Research. 349: 310-319. PMID 27818247 DOI: 10.1016/J.Yexcr.2016.10.025 |
0.415 |
|
| 2016 |
Compton LM, Ikonomov OC, Sbrissa D, Garg P, Shisheva A. Active vacuolar H+ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. American Journal of Physiology. Cell Physiology. ajpcell.00104.2016. PMID 27335171 DOI: 10.1152/Ajpcell.00104.2016 |
0.47 |
|
| 2016 |
Ikonomov OC, Sbrissa D, Delvecchio K, Rillema JA, Shisheva A. Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiological Reports. 4. PMID 27273882 DOI: 10.14814/Phy2.12812 |
0.38 |
|
| 2016 |
Venkatareddy M, Verma R, Kalinowski A, Patel SR, Shisheva A, Garg P. Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells. Journal of the American Society of Nephrology : Jasn. PMID 26825532 DOI: 10.1681/Asn.2015050555 |
0.489 |
|
| 2015 |
Ikonomov OC, Sbrissa D, Compton LM, Kumar R, Tisdale EJ, Chen X, Shisheva A. The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation. The Journal of Biological Chemistry. PMID 26405034 DOI: 10.1074/Jbc.M115.669929 |
0.339 |
|
| 2015 |
Ikonomov OC, Sbrissa D, Venkatareddy M, Tisdale E, Garg P, Shisheva A. Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis. Biochimica Et Biophysica Acta. 1853: 1240-50. PMID 25619930 DOI: 10.1016/J.Bbamcr.2015.01.008 |
0.447 |
|
| 2015 |
Shisheva A, Sbrissa D, Ikonomov O. Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012). Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 267-77. PMID 25404370 DOI: 10.1002/Bies.201400129 |
0.365 |
|
| 2015 |
Sbrissa D, Semaan L, Yanfeng L, Shisheva A, Chinni SR. Abstract 5162: Phosphatidylinositol 4-Kinase type IIIa (PI4KA) expression in prostate cancer Cancer Research. 75: 5162-5162. DOI: 10.1158/1538-7445.Am2015-5162 |
0.418 |
|
| 2014 |
Thieleke-Matos C, da Silva ML, Cabrita-Santos L, Pires CF, Ramalho JS, Ikonomov O, Seixas E, Shisheva A, Seabra MC, Barral DC. Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection. Traffic (Copenhagen, Denmark). 15: 1066-82. PMID 24992508 DOI: 10.1111/Tra.12190 |
0.34 |
|
| 2014 |
Tisdale EJ, Shisheva A, Artalejo CR. Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation. Cellular Signalling. 26: 1235-42. PMID 24582589 DOI: 10.1016/J.Cellsig.2014.02.014 |
0.431 |
|
| 2014 |
Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L. cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease. Molecular Pharmacology. 85: 441-50. PMID 24366666 DOI: 10.1124/Mol.113.090837 |
0.399 |
|
| 2013 |
Ikonomov OC, Filios C, Sbrissa D, Chen X, Shisheva A. The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines. Biochemical and Biophysical Research Communications. 440: 342-7. PMID 24070605 DOI: 10.1016/J.Bbrc.2013.09.080 |
0.369 |
|
| 2013 |
Shisheva A. PtdIns5P: news and views of its appearance, disappearance and deeds. Archives of Biochemistry and Biophysics. 538: 171-80. PMID 23916588 DOI: 10.1016/J.Abb.2013.07.023 |
0.354 |
|
| 2013 |
Ikonomov OC, Sbrissa D, Delvecchio K, Feng HZ, Cartee GD, Jin JP, Shisheva A. Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching. American Journal of Physiology. Endocrinology and Metabolism. 305: E119-31. PMID 23673157 DOI: 10.1152/Ajpendo.00030.2013 |
0.361 |
|
| 2012 |
Shisheva A. PIKfyve and its Lipid products in health and in sickness. Current Topics in Microbiology and Immunology. 362: 127-62. PMID 23086417 DOI: 10.1007/978-94-007-5025-8_7 |
0.407 |
|
| 2012 |
Sbrissa D, Ikonomov OC, Filios C, Delvecchio K, Shisheva A. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. American Journal of Physiology. Cell Physiology. 303: C436-46. PMID 22621786 DOI: 10.1152/Ajpcell.00105.2012 |
0.472 |
|
| 2011 |
Ikonomov OC, Sbrissa D, Delvecchio K, Xie Y, Jin JP, Rappolee D, Shisheva A. The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice. The Journal of Biological Chemistry. 286: 13404-13. PMID 21349843 DOI: 10.1074/Jbc.M111.222364 |
0.399 |
|
| 2010 |
Ikonomov OC, Sbrissa D, Fligger J, Delvecchio K, Shisheva A. ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder. The Journal of Biological Chemistry. 285: 26760-4. PMID 20630877 DOI: 10.1074/jbc.C110.154658 |
0.364 |
|
| 2009 |
Ikonomov OC, Sbrissa D, Fenner H, Shisheva A. PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. The Journal of Biological Chemistry. 284: 35794-806. PMID 19840946 DOI: 10.1074/jbc.M109.037515 |
0.369 |
|
| 2009 |
Ikonomov OC, Sbrissa D, Ijuin T, Takenawa T, Shisheva A. Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes. The Journal of Biological Chemistry. 284: 23961-71. PMID 19578118 DOI: 10.1074/Jbc.M109.025361 |
0.424 |
|
| 2009 |
Ikonomov OC, Sbrissa D, Shisheva A. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochemical and Biophysical Research Communications. 382: 566-70. PMID 19289105 DOI: 10.1016/J.Bbrc.2009.03.063 |
0.39 |
|
| 2009 |
Ikonomov OC, Fligger J, Sbrissa D, Dondapati R, Mlak K, Deeb R, Shisheva A. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. The Journal of Biological Chemistry. 284: 3750-61. PMID 19056739 DOI: 10.1074/jbc.M806539200 |
0.325 |
|
| 2009 |
Shisheva A, Czech MP. O-19: Increased cytosolic Rab4 mediated by insulin selectively associates with the GDI-1 isoform in 3T3-L1 adipocytes Experimental and Clinical Endocrinology & Diabetes. 104: 27-29. DOI: 10.1055/S-0029-1211510 |
0.511 |
|
| 2008 |
Sbrissa D, Ikonomov OC, Fenner H, Shisheva A. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. Journal of Molecular Biology. 384: 766-79. PMID 18950639 DOI: 10.1016/J.Jmb.2008.10.009 |
0.407 |
|
| 2008 |
Shisheva A. Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3. American Journal of Physiology. Endocrinology and Metabolism. 295: E536-44. PMID 18492765 DOI: 10.1152/Ajpendo.90353.2008 |
0.489 |
|
| 2008 |
Shisheva A. PIKfyve: Partners, significance, debates and paradoxes. Cell Biology International. 32: 591-604. PMID 18304842 DOI: 10.1016/J.Cellbi.2008.01.006 |
0.45 |
|
| 2007 |
Kim J, Jahng WJ, Di Vizio D, Lee JS, Jhaveri R, Rubin MA, Shisheva A, Freeman MR. The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Research. 67: 9229-37. PMID 17909029 DOI: 10.1158/0008-5472.Can-07-1333 |
0.333 |
|
| 2007 |
Sbrissa D, Ikonomov OC, Fu Z, Ijuin T, Gruenberg J, Takenawa T, Shisheva A. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. The Journal of Biological Chemistry. 282: 23878-91. PMID 17556371 DOI: 10.1074/Jbc.M611678200 |
0.486 |
|
| 2007 |
Ikonomov OC, Sbrissa D, Dondapati R, Shisheva A. ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. Experimental Cell Research. 313: 2404-16. PMID 17475247 DOI: 10.1016/J.Yexcr.2007.03.024 |
0.43 |
|
| 2006 |
Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA. Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Molecular and Cellular Biology. 26: 6065-81. PMID 16880518 DOI: 10.1128/Mcb.00203-06 |
0.443 |
|
| 2006 |
Ikonomov OC, Sbrissa D, Shisheva A. Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion. American Journal of Physiology. Cell Physiology. 291: C393-404. PMID 16510848 DOI: 10.1152/ajpcell.00019.2006 |
0.396 |
|
| 2006 |
Xu Y, Lee SA, Kutateladze TG, Sbrissa D, Shisheva A, Prestwich GD. Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. Journal of the American Chemical Society. 128: 885-97. PMID 16417379 DOI: 10.1021/Ja0554716 |
0.333 |
|
| 2005 |
Sbrissa D, Ikonomov OC, Shisheva A. Analysis of potential binding of the recombinant Rab9 effector p40 to phosphoinositide-enriched synthetic liposomes. Methods in Enzymology. 403: 696-705. PMID 16473631 DOI: 10.1016/S0076-6879(05)03060-0 |
0.348 |
|
| 2005 |
Sbrissa D, Shisheva A. Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway. The Journal of Biological Chemistry. 280: 7883-9. PMID 15546865 DOI: 10.1074/jbc.M412729200 |
0.373 |
|
| 2004 |
Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, Silver R, Shisheva A. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Molecular and Cellular Biology. 24: 10437-47. PMID 15542851 DOI: 10.1128/Mcb.24.23.10437-10447.2004 |
0.514 |
|
| 2004 |
Sbrissa D, Ikonomov OC, Strakova J, Shisheva A. Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation. Endocrinology. 145: 4853-65. PMID 15284192 DOI: 10.1210/En.2004-0489 |
0.47 |
|
| 2004 |
Tsujita K, Itoh T, Ijuin T, Yamamoto A, Shisheva A, Laporte J, Takenawa T. Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. The Journal of Biological Chemistry. 279: 13817-24. PMID 14722070 DOI: 10.1074/Jbc.M312294200 |
0.387 |
|
| 2003 |
Ikonomov OC, Sbrissa D, Foti M, Carpentier JL, Shisheva A. PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Molecular Biology of the Cell. 14: 4581-91. PMID 14551253 DOI: 10.1091/Mbc.E03-04-0222 |
0.432 |
|
| 2003 |
Ikonomov OC, Sbrissa D, Mlak K, Deeb R, Fligger J, Soans A, Finley RL, Shisheva A. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. The Journal of Biological Chemistry. 278: 50863-71. PMID 14530284 DOI: 10.1074/Jbc.M307260200 |
0.501 |
|
| 2003 |
Shisheva A. Regulating Glut4 vesicle dynamics by phosphoinositide kinases and phosphoinositide phosphatases. Frontiers in Bioscience : a Journal and Virtual Library. 8: s945-6. PMID 12957825 DOI: 10.2741/1101 |
0.466 |
|
| 2002 |
Ikonomov OC, Sbrissa D, Mlak K, Shisheva A. Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects. Endocrinology. 143: 4742-54. PMID 12446602 DOI: 10.1210/En.2002-220615 |
0.453 |
|
| 2002 |
Sbrissa D, Ikonomov OC, Deeb R, Shisheva A. Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. The Journal of Biological Chemistry. 277: 47276-84. PMID 12270933 DOI: 10.1074/Jbc.M207576200 |
0.475 |
|
| 2002 |
Ikonomov OC, Sbrissa D, Yoshimori T, Cover TL, Shisheva A. PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin. The Journal of Biological Chemistry. 277: 46785-90. PMID 12213828 DOI: 10.1074/Jbc.M208068200 |
0.459 |
|
| 2002 |
Ikonomov OC, Sbrissa D, Mlak K, Kanzaki M, Pessin J, Shisheva A. Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity. The Journal of Biological Chemistry. 277: 9206-11. PMID 11714711 DOI: 10.1074/Jbc.M108750200 |
0.622 |
|
| 2002 |
Sbrissa D, Ikonomov OC, Shisheva A. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization. The Journal of Biological Chemistry. 277: 6073-9. PMID 11706043 DOI: 10.1074/Jbc.M110194200 |
0.415 |
|
| 2001 |
Sbrissa D, Ikonomov O, Shisheva A. Selective insulin-induced activation of class IA phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes☆ Molecular and Cellular Endocrinology. 181: 35-46. PMID 11476939 DOI: 10.1016/S0303-7207(01)00539-1 |
0.421 |
|
| 2001 |
Ikonomov OC, Sbrissa D, Shisheva A. Mammalian Cell Morphology and Endocytic Membrane Homeostasis Require Enzymatically Active Phosphoinositide 5-Kinase PIKfyve Journal of Biological Chemistry. 276: 26141-26147. PMID 11285266 DOI: 10.1074/Jbc.M101722200 |
0.496 |
|
| 2001 |
Shisheva A. 5 - Antibody and Oligonucleotide Probes to Distinguish Intracellular Expression and Localization Patterns of Rab GDP-Dissociation Inhibitor Isoforms Methods in Enzymology. 329: 39-50. PMID 11210559 DOI: 10.1016/S0076-6879(01)29064-8 |
0.422 |
|
| 2001 |
Shisheva A, Rusin B, Ikonomov OC, DeMarco C, Sbrissa D. Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes. Journal of Biological Chemistry. 276: 11859-11869. PMID 11112776 DOI: 10.1074/Jbc.M008437200 |
0.493 |
|
| 1999 |
McEwen RK, Dove SK, Cooke FT, Painter GF, Holmes AB, Shisheva A, Ohya Y, Parker PJ, Michell RH. Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases. The Journal of Biological Chemistry. 274: 33905-12. PMID 10567352 DOI: 10.1074/Jbc.274.48.33905 |
0.492 |
|
| 1999 |
Shisheva A, Chinni SR, DeMarco C. General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. Biochemistry. 38: 11711-11721. PMID 10512627 DOI: 10.1021/Bi990200R |
0.39 |
|
| 1999 |
Sbrissa D, Ikonomov OC, Shisheva A. PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. Journal of Biological Chemistry. 274: 21589-21597. PMID 10419465 DOI: 10.1074/Jbc.274.31.21589 |
0.497 |
|
| 1999 |
Shisheva A, Sbrissa D, Ikonomov O. Cloning, Characterization, and Expression of a Novel Zn2+-Binding FYVE Finger-Containing Phosphoinositide Kinase in Insulin-Sensitive Cells Molecular and Cellular Biology. 19: 623-634. PMID 9858586 DOI: 10.1128/Mcb.19.1.623 |
0.502 |
|
| 1999 |
Chinni SR, Shisheva A. Arrest of endosome acidification by bafilomycin A1 mimics insulin action on GLUT4 translocation in 3T3-L1 adipocytes. Biochemical Journal. 339: 599-606. DOI: 10.1042/Bj3390599 |
0.408 |
|
| 1998 |
Chinni SR, Brenz M, Shisheva A. Modulation of GDP-Dissociation Inhibitor Protein Membrane Retention by the Cellular Redox State in Adipocytes Experimental Cell Research. 242: 373-380. PMID 9665834 DOI: 10.1006/Excr.1998.4105 |
0.416 |
|
| 1994 |
Shisheva A, Südhof TC, Czech MP. Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Molecular and Cellular Biology. 14: 3459-68. PMID 7513052 DOI: 10.1128/Mcb.14.5.3459 |
0.556 |
|
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