| Year |
Citation |
Score |
| 2023 |
Shada ADR, Mangunuru HPR, Terrab L, Tenneti S, Kalikinidi NR, Naini SR, Gajula P, Crull EB, Janganati V, Kovvuri R, Natarajan V, Lee D, Yin J, Samankumara L, Mahar R, ... ... Senanayake CH, et al. Design and Discovery of Water-Soluble Benzooxaphosphole-Based Ligands for Hindered Suzuki-Miyaura Coupling Reactions with Low Catalyst Load. Organic Letters. PMID 37486800 DOI: 10.1021/acs.orglett.3c01663 |
0.323 |
|
| 2022 |
Desrosiers JN, Xu Y, Kosnik SC, Qu B, Lao KS, Senanayake CH, Zhang Y. A Practical Method for the Large-Scale Preparation of the -Chiral Dihydrobenzoazaphosphole Core by Chemical Resolution. The Journal of Organic Chemistry. 87: 11218-11221. PMID 35930810 DOI: 10.1021/acs.joc.2c00495 |
0.788 |
|
| 2021 |
Gopalsamuthiram V, Kadam AL, Noble JK, Snead DR, Williams C, Jamison TF, Senanayake C, Yadaw AK, Roy S, Sirasani G, Gupton BF, Burns J, Cook DW, Stringham RW, Ahmad S, et al. Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis. Organic Process Research & Development. 25: 2679-2685. PMID 34955627 DOI: 10.1021/acs.oprd.1c00219 |
0.319 |
|
| 2021 |
Kerner MJ, Kuttruff CA, Chevliakov M, Buono FG, Gao DA, Krawiec M, Busacca CA, Senanayake CH, Wipf P, Reeves JT. Carbamoyl Anion Addition to Azirines. Organic Letters. PMID 33988373 DOI: 10.1021/acs.orglett.1c01334 |
0.303 |
|
| 2021 |
Liu M, Tang T, Apolinar O, Matsuura R, Busacca CA, Qu B, Fandrick DR, Zatolochnaya OV, Senanayake CH, Song JJ, Engle KM. Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes. Journal of the American Chemical Society. PMID 33683868 DOI: 10.1021/jacs.0c12565 |
0.363 |
|
| 2020 |
Qu B, Samankumara LP, Saha A, Schumer MG, Han ZS, Haddad N, Busacca CA, Yee NK, Kozlowski MC, Song JJ, Senanayake CH. Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 31: 587-591. PMID 33542591 DOI: 10.1055/S-0039-1690851 |
0.327 |
|
| 2020 |
Patel ND, Wei X, Byrne D, Narayanan B, Pennino S, Sarvestani M, Saha AK, Haddad N, Kapadia S, Lorenz JC, Decroos P, Ye A, Lee H, Grinberg N, Hossain A, ... ... Senanayake CH, et al. Sulfone Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and more - Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420. The Journal of Organic Chemistry. PMID 32462862 DOI: 10.1021/Acs.Joc.0C00554 |
0.362 |
|
| 2020 |
Biswas S, Qu B, Desrosiers JN, Choi Y, Haddad N, Yee NK, Song JJ, Senanayake CH. Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides. The Journal of Organic Chemistry. PMID 32452201 DOI: 10.1021/Acs.Joc.0C00549 |
0.414 |
|
| 2019 |
Wu L, Zatolochnaya O, Qu B, Wu L, Wells LA, Kozlowski MC, Senanayake CH, Song JJ, Zhang Y. Cu-Catalyzed Asymmetric Aminoboration of -Vinylarenes with ZPhos as the Ligand. Organic Letters. PMID 31647668 DOI: 10.1021/Acs.Orglett.9B03328 |
0.395 |
|
| 2019 |
Li SG, Yuan M, Topić F, Han ZS, Senanayake CH, Tsantrizos YS. Asymmetric Library Synthesis of P-Chiral t-Butyl-Substituted Secondary and Tertiary Phosphine Oxides. The Journal of Organic Chemistry. PMID 31099249 DOI: 10.1021/Acs.Joc.9B00945 |
0.408 |
|
| 2019 |
Chong E, Qu B, Zhang Y, Cannone ZP, Leung JC, Tcyrulnikov S, Nguyen KD, Haddad N, Biswas S, Hou X, Kaczanowska K, Chwalba M, Tracz A, Czarnocki S, Song JJ, ... ... Senanayake CH, et al. A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes. Chemical Science. 10: 4339-4345. PMID 31057761 DOI: 10.1039/C8Sc05612A |
0.418 |
|
| 2019 |
Xu G, Senanayake CH, Tang W. P-Chiral Phosphorus Ligands Based on a 2,3-Dihydrobenzo[ d][1,3]oxaphosphole Motif for Asymmetric Catalysis. Accounts of Chemical Research. PMID 30848882 DOI: 10.1021/Acs.Accounts.9B00029 |
0.461 |
|
| 2019 |
Qu B, Tan R, Herling MR, Haddad N, Grinberg N, Kozlowski MC, Zhang X, Senanayake CH. Enantioselective Synthesis of 4-Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene Derivatives. The Journal of Organic Chemistry. PMID 30779574 DOI: 10.1021/Acs.Joc.8B02813 |
0.434 |
|
| 2019 |
Sieber JD, Buono F, Brusoe A, Desrosiers JN, Haddad N, Lorenz JC, Xu Y, Wu H, Zhang L, Han ZS, Roschangar F, Song JJ, Yee NK, Senanayake CH. Application of a Preformed Pd-BIDIME Precatalyst to Suzuki-Miyaura Cross-Coupling Reaction in Flow. The Journal of Organic Chemistry. PMID 30715884 DOI: 10.1021/Acs.Joc.8B03040 |
0.38 |
|
| 2019 |
DeCroos P, Han ZS, Sidhu K, Lorenz J, Nummy L, Byrne D, Qu B, Xu Y, Wu L, Lee H, Roschangar F, Song JJ, Senanayake CH. Development of a Large-Scale Asymmetric Process fortert-Butanesulfinamide Organic Process Research & Development. 23: 263-268. DOI: 10.1021/Acs.Oprd.8B00399 |
0.43 |
|
| 2019 |
Han ZS, Wu H, Qu B, Wang Y, Wu L, Zhang L, Xu Y, Wu L, Zhang Y, Lee H, Roschangar F, Song JJ, Senanayake CH. New class of P-stereogenic chiral Brønsted acid catalysts derived from chiral phosphinamides Tetrahedron Letters. 60: 1834-1837. DOI: 10.1016/J.Tetlet.2019.06.013 |
0.391 |
|
| 2018 |
Latli B, Hrapchak M, Li G, Lorenz J, Horan J, Busacca CA, Senanayake CH. Synthesis of highly potent Lymphocyte Function-Associated Antigen-1 Antagonists Labeled with Carbon-14 and with Stable Isotopes, Part 3. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 30466143 DOI: 10.1002/Jlcr.3698 |
0.42 |
|
| 2018 |
Patel ND, Sieber JD, Tcyrulnikov S, Simmons BJ, Rivalti D, Duvvuri K, Zhang Y, Gao DA, Fandrick KR, Haddad N, Lao KS, Mangunuru HPR, Biswas S, Qu B, Grinberg N, ... ... Senanayake CH, et al. Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-Substituted Biaryl Synthesis. Acs Catalysis. 8: 10190-10209. PMID 30450265 DOI: 10.1021/Acscatal.8B02509 |
0.804 |
|
| 2018 |
Zatolochnaya OV, Rodríguez S, Zhang Y, Lao KS, Tcyrulnikov S, Li G, Wang XJ, Qu B, Biswas S, Mangunuru HPR, Rivalti D, Sieber JD, Desrosiers JN, Leung JC, Grinberg N, ... ... Senanayake CH, et al. Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones dynamic kinetic resolution. Chemical Science. 9: 4505-4510. PMID 29896393 DOI: 10.1039/C8Sc00434J |
0.775 |
|
| 2018 |
Li G, Zatolochnaya OV, Wang XJ, Rodríguez S, Qu B, Desrosiers JN, Mangunuru HPR, Biswas S, Rivalti D, Karyakarte SD, Sieber JD, Grinberg N, Wu L, Lee H, Haddad N, ... ... Senanayake CH, et al. BABIPhos Family of Biaryl Dihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation. Organic Letters. PMID 29542928 DOI: 10.1021/Acs.Orglett.8B00139 |
0.425 |
|
| 2018 |
Zhu RY, Li ZQ, Park HS, Senanayake CH, Yu JQ. Ligand-Enabled γ-C(sp3)-H Activation of Ketones. Journal of the American Chemical Society. PMID 29481072 DOI: 10.1021/Jacs.8B01359 |
0.347 |
|
| 2018 |
Qu B, Mangunuru HPR, Tcyrulnikov S, Rivalti D, Zatolochnaya OV, Kurouski D, Radomkit S, Biswas S, Karyakarte S, Fandrick KR, Sieber JD, Rodriguez S, Desrosiers JN, Haddad N, McKellop K, ... ... Senanayake CH, et al. Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights. Organic Letters. PMID 29461064 DOI: 10.1021/Acs.Orglett.8B00067 |
0.415 |
|
| 2018 |
Sieber JD, Rodriguez S, Frutos R, Buono F, Zhang Y, Li N, Qu B, Premasiri A, Li Z, Han ZS, Xu Y, Byrne D, Haddad N, Lorenz J, Grinberg N, ... ... Senanayake CH, et al. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative in High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation. The Journal of Organic Chemistry. PMID 29323903 DOI: 10.1021/Acs.Joc.7B03022 |
0.481 |
|
| 2018 |
Zhang Y, Senanayake C, Lao K, Sieber J, Xu Y, Wu L, Wang X, Desrosiers J, Lee H, Haddad N, Han Z, Yee N, Song J, Howell A. Modular Dihydrobenzoazaphosphole Ligands for Suzuki–Miyaura Cross-Coupling Synthesis. 50: 4429-4434. DOI: 10.1055/S-0037-1610158 |
0.78 |
|
| 2018 |
Eriksson M, Zeng X, Xu J, Reeves D, Busacca C, Farina V, Senanayake C. The Guareschi–Thorpe Cyclization Revisited – An Efficient Synthesis of Substituted 2,6-Dihydroxypyridines and 2,6-Dichloropyridines Synlett. 29: 1455-1460. DOI: 10.1055/S-0037-1609685 |
0.454 |
|
| 2018 |
Haddad N, Senanayake C, Mangunuru H, Malapit C, Reeves J, Qu B, Rodriguez S, Lee H, Yee N, Song J, Busacca C. Enantioselective Arylation of Oxindoles Using Modified BI-DIME Ligands Synthesis. 50: 4435-4443. DOI: 10.1055/S-0036-1591590 |
0.45 |
|
| 2017 |
Zou Y, Gutierrez O, Sader AC, Patel ND, Fandrick DR, Busacca CA, Fandrick KR, Kozlowski M, Senanayake CH. A Computational Investigation of the Ligand-Controlled Cu-Catalyzed Site-Selective Propargylation and Allenylation of Carbonyl Compounds. Organic Letters. PMID 29095633 DOI: 10.1021/Acs.Orglett.7B02845 |
0.371 |
|
| 2017 |
Zhu RY, Liu LY, Park HS, Hong K, Wu Y, Senanayake CH, Yu JQ. Versatile Alkylation of (Hetero)Aryl Iodides with Ketones via β-C(sp3)-H Activation. Journal of the American Chemical Society. PMID 29086554 DOI: 10.1021/Jacs.7B09761 |
0.394 |
|
| 2017 |
Desrosiers JN, Wen J, Tcyrulnikov S, Biswas S, Qu B, Hie L, Kurouski D, Wu L, Grinberg N, Haddad N, Busacca CA, Yee NK, Song JJ, Garg NK, Zhang X, ... ... Senanayake CH, et al. Enantioselective Nickel-Catalyzed Mizoroki-Heck Cyclizations To Generate Quaternary Stereocenters. Organic Letters. PMID 28604006 DOI: 10.1021/Acs.Orglett.7B01054 |
0.467 |
|
| 2017 |
Latli B, Hrapchak M, Savoie J, Zhan Y, Busacca CA, Senanayake CH. Potent and Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Labeled with Carbon-13 and Carbon-14. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 28494515 DOI: 10.1002/Jlcr.3518 |
0.386 |
|
| 2017 |
Malapit CA, Caldwell DR, Luvaga IK, Reeves JT, Volchkov I, Gonnella NC, Han ZS, Busacca CA, Howell AR, Senanayake CH. Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles. Angewandte Chemie (International Ed. in English). PMID 28493607 DOI: 10.1002/Anie.201703471 |
0.421 |
|
| 2017 |
Li G, Wang XJ, Zhang Y, Tan Z, DeCroos P, Lorenz JC, Wei X, Grinberg N, Yee NK, Senanayake CH. Synthesis of P-Chiral Dihydrobenzooxaphosphole (BOP) Core for BI Ligands in Asymmetric Transformations. The Journal of Organic Chemistry. PMID 28459568 DOI: 10.1021/Acs.Joc.7B00491 |
0.407 |
|
| 2017 |
Malapit CA, Luvaga IK, Reeves JT, Volchkov I, Busacca CA, Howell AR, Senanayake CH. 1,4-Dicarbofunctionalization of 4-Fluoroaryl Grignard and Lithium Reagents with Disubstituted Malononitriles. The Journal of Organic Chemistry. PMID 28402664 DOI: 10.1021/Acs.Joc.7B00567 |
0.426 |
|
| 2017 |
Zhu RY, Saint-Denis TG, Shao Y, He J, Sieber JD, Senanayake CH, Yu JQ. Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds. Journal of the American Chemical Society. PMID 28391681 DOI: 10.1021/Jacs.7B02196 |
0.406 |
|
| 2017 |
Han ZS, Wu H, Xu Y, Zhang Y, Qu B, Li Z, Caldwell DR, Fandrick KR, Zhang L, Roschangar F, Song JJ, Senanayake CH. General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides. Organic Letters. PMID 28351151 DOI: 10.1021/Acs.Orglett.7B00568 |
0.424 |
|
| 2017 |
Li SG, Han ZS, Viereck P, Lee H, Kurouski D, Senanayake CH, Tsantrizos YS. Metal-Free Cycloetherification by in Situ Generated P-Stereogenic α-Diazanium Intermediates: A Convergent Synthesis of Enantiomerically Pure Dihydrobenzooxaphospholes. Organic Letters. PMID 28155279 DOI: 10.1021/Acs.Orglett.7B00051 |
0.419 |
|
| 2017 |
Lautens M, Johnson T, Fandrick DR, Hart CA, Okafor IS, Mercadante MA, Sanyal S, Masters JT, Sarvestani M, Fandrick KR, Stockdill JL, Grinberg N, Gonnella N, Lee H, Senanayake CH. Copper-Catalyzed Propargylation of Cyclic Aldimines Synfacts. 13: 169-169. DOI: 10.1055/S-0036-1589899 |
0.365 |
|
| 2017 |
Haddad N, Mangunuru HPR, Fandrick KR, Qu B, Sieber JD, Rodriguez S, Desrosiers J-, Patel ND, Lee H, Kurouski D, Grinberg N, Yee NK, Song JJ, Senanayake CH. Ligand Effect on Diastereoselectivity in Suzuki–Miyaura Coupling Synfacts. 13: 168-168. DOI: 10.1055/S-0036-1589875 |
0.338 |
|
| 2017 |
Marsini MA, Buono FG, Lorenz JC, Yang B, Reeves JT, Sidhu K, Sarvestani M, Tan Z, Zhang Y, Li N, Lee H, Brazzillo J, Nummy LJ, Chung JC, Luvaga IK, ... ... Senanayake CH, et al. Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement Green Chemistry. 19: 1454-1461. DOI: 10.1039/C6Gc03123D |
0.309 |
|
| 2017 |
Mulder JA, Gao J, Fandrick KR, Zeng X, Desrosiers J, Patel ND, Li Z, Rodriguez S, Lorenz JC, Wang J, Ma S, Fandrick DR, Grinberg N, Lee H, Bosanac T, ... ... Senanayake CH, et al. Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor Organic Process Research & Development. 21: 1427-1434. DOI: 10.1021/Acs.Oprd.7B00202 |
0.392 |
|
| 2017 |
Rodríguez S, Haddad N, Frutos RP, Grinberg N, Krishnamurthy D, Senanayake CH. Asymmetric Oxidation of a Dihydrothienopyrimidine Organic Process Research & Development. 21: 444-447. DOI: 10.1021/Acs.Oprd.6B00400 |
0.368 |
|
| 2017 |
Patel ND, Rivalti D, Buono FG, Chatterjee A, Qu B, Braith S, Desrosiers J, Rodriguez S, Sieber JD, Haddad N, Fandrick KR, Lee H, Yee NK, Busacca CA, Senanayake CH. Effective BI-DIME Ligand for Suzuki-Miyaura Cross-Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X Asian Journal of Organic Chemistry. 6: 1285-1291. DOI: 10.1002/Ajoc.201700137 |
0.354 |
|
| 2017 |
Wu H, Han ZS, Qu B, Wang D, Zhang Y, Xu Y, Grinberg N, Lee H, Song JJ, Roschangar F, Wang G, Senanayake CH. P-Stereogenic Chiral Phosphine−Palladium Complex Catalyzed Enantioselective Synthesis of Phosphoryl-Substituted Atropisomeric Vinylarenes Advanced Synthesis & Catalysis. 359: 3927-3933. DOI: 10.1002/Adsc.201700837 |
0.493 |
|
| 2016 |
Desrosiers JN, Wei X, Gutierrez O, Savoie J, Qu B, Zeng X, Lee H, Grinberg N, Haddad N, Yee NK, Roschangar F, Song JJ, Kozlowski MC, Senanayake CH. Nickel-Catalyzed C-3 Direct Arylation of Pyridinium Ions for the Synthesis of 1-Azafluorenes. Chemical Science. 7: 5581-5586. PMID 28111599 DOI: 10.1039/C6Sc01457G |
0.451 |
|
| 2016 |
Fandrick DR, Hart CA, Okafor IS, Mercadante MA, Sanyal S, Masters JT, Sarvestani M, Fandrick KR, Stockdill JL, Grinberg N, Gonnella N, Lee H, Senanayake CH. Copper-Catalyzed Asymmetric Propargylation of Cyclic Aldimines. Organic Letters. 18: 6192-6195. PMID 27934338 DOI: 10.1021/Acs.Orglett.6B03253 |
0.48 |
|
| 2016 |
Hie L, Baker EL, Anthony SM, Desrosiers JN, Senanayake C, Garg NK. Nickel-Catalyzed Esterification of Aliphatic Amides. Angewandte Chemie (International Ed. in English). PMID 27813308 DOI: 10.1002/Anie.201607856 |
0.412 |
|
| 2016 |
Wei X, Qu B, Zeng X, Savoie J, Fandrick KR, Desrosiers JN, Tcyrulnikov S, Marsini MA, Buono FG, Li Z, Yang BS, Tang W, Haddad N, Gutierrez O, Wang J, ... ... Senanayake CH, et al. Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor. Journal of the American Chemical Society. PMID 27794616 DOI: 10.1021/Jacs.6B09764 |
0.451 |
|
| 2016 |
Latli B, Stiasni M, Hrapchak M, Li Z, Grinberg N, Lee H, Busacca CA, Senanayake CH. Buscopan labeled with carbon-14 and deuterium. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27753138 DOI: 10.1002/Jlcr.3463 |
0.307 |
|
| 2016 |
Qu B, Mangunuru HP, Wei X, Fandrick KR, Desrosiers JN, Sieber JD, Kurouski D, Haddad N, Samankumara LP, Lee H, Savoie J, Ma S, Grinberg N, Sarvestani M, Yee NK, ... ... Senanayake CH, et al. Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts. Organic Letters. PMID 27661252 DOI: 10.1021/Acs.Orglett.6B02401 |
0.466 |
|
| 2016 |
Desrosiers JN, Hie L, Biswas S, Zatolochnaya OV, Rodriguez S, Lee H, Grinberg N, Haddad N, Yee NK, Garg NK, Senanayake CH. Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions. Angewandte Chemie (International Ed. in English). PMID 27600647 DOI: 10.1002/Anie.201606955 |
0.437 |
|
| 2016 |
Milligan JA, Busacca CA, Senanayake CH, Wipf P. Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles. Organic Letters. PMID 27518583 DOI: 10.1021/Acs.Orglett.6B02051 |
0.441 |
|
| 2016 |
Tan R, Zheng X, Qu B, Sader CA, Fandrick KR, Senanayake CH, Zhang X. Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation. Organic Letters. PMID 27333435 DOI: 10.1021/Acs.Orglett.6B01452 |
0.403 |
|
| 2016 |
Kim B, Chinn AJ, Fandrick DR, Senanayake CH, Singer RA, Miller SJ. Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling. Journal of the American Chemical Society. PMID 27254785 DOI: 10.1021/Jacs.6B03444 |
0.348 |
|
| 2016 |
Latli B, Kiesling R, Aßfalg S, Chevliakov M, Hrapchak M, Campbell S, Gonnella N, Busacca CA, Senanayake CH. Carbon-13 and carbon-14 labeled dabigatran etexilate and tritium labeled dabigatran. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27146196 DOI: 10.1002/Jlcr.3402 |
0.325 |
|
| 2016 |
Latli B, Eriksson M, Hrapchak M, Busacca CA, Senanayake CH. A potent IκB kinase-β inhibitor labeled with carbon-14 and deuterium. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27073120 DOI: 10.1002/Jlcr.3398 |
0.37 |
|
| 2016 |
Zhang Y, Wu JP, Li G, Fandrick KR, Gao J, Tan Z, Johnson J, Li W, Sanyal S, Wang J, Sun X, Lorenz JC, Rodriguez S, Reeves JT, Grinberg N, ... ... Senanayake CH, et al. An Enantioselective Synthesis of an 11-beta-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3'-F2-BINOL. The Journal of Organic Chemistry. PMID 26909738 DOI: 10.1021/Acs.Joc.6B00189 |
0.409 |
|
| 2016 |
Qu B, Haddad N, Rodriguez S, Sieber JD, Desrosiers JN, Patel ND, Zhang Y, Grinberg N, Lee H, Ma S, Ries UJ, Yee NK, Senanayake CH. Ligand Accelerated Stereoretentive Suzuki-Miyaura Coupling of Unprotected 3,3'-Dibromo-BINOL. The Journal of Organic Chemistry. PMID 26756863 DOI: 10.1021/Acs.Joc.5B02368 |
0.467 |
|
| 2016 |
Sieber JD, Rivalti D, Herbage MA, Masters JT, Fandrick KR, Fandrick DR, Haddad N, Lee H, Yee NK, Gupton BF, Senanayake CH. Rh-catalysed asymmetric conjugate addition of boronic acids to nitroalkenes employing a: P -chiral P,π-hybrid ligand Organic Chemistry Frontiers. 3: 1149-1153. DOI: 10.1039/C6Qo00311G |
0.433 |
|
| 2016 |
Frutos RP, Tampone TG, Mulder JA, Rodriguez S, Yee NK, Yang B, Senanayake CH. Development of a Practical Process for the Synthesis of PDE4 Inhibitors Organic Process Research & Development. 20: 982-988. DOI: 10.1021/Acs.Oprd.6B00104 |
0.385 |
|
| 2016 |
Patel ND, Zhang Y, Gao J, Sidhu K, Lorenz JC, Fandrick KR, Mulder JA, Herbage MA, Li Z, Ma S, Lee H, Grinberg N, Song JJ, Busacca CA, Yee NK, ... Senanayake CH, et al. Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid Organic Process Research and Development. 20: 95-99. DOI: 10.1021/Acs.Oprd.5B00360 |
0.421 |
|
| 2016 |
Visco MD, Reeves JT, Marsini MA, Volchkov I, Busacca CA, Mattson AE, Senanayake CH. Triisopropyl borate mediated N-sulfinyl imine formation Tetrahedron Letters. DOI: 10.1016/J.Tetlet.2016.03.063 |
0.393 |
|
| 2016 |
Buono FG, Zhang Y, Tan Z, Brusoe A, Yang BS, Lorenz JC, Giovannini R, Song JJ, Yee NK, Senanayake CH. Efficient Iron-Catalyzed Kumada Cross-Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings European Journal of Organic Chemistry. DOI: 10.1002/Ejoc.201600275 |
0.379 |
|
| 2016 |
Haddad N, Mangunuru HPR, Fandrick KR, Qu B, Sieber JD, Rodriguez S, Desrosiers J, Patel ND, Lee H, Kurouski D, Grinberg N, Yee NK, Song JJ, Senanayake CH. Reengineered BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki-Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor Advanced Synthesis & Catalysis. 358: 3522-3527. DOI: 10.1002/Adsc.201600889 |
0.412 |
|
| 2016 |
Sieber JD, Angeles-Dunham VV, Chennamadhavuni D, Fandrick DR, Haddad N, Grinberg N, Kurouski D, Lee H, Song JJ, Yee NK, Mattson AE, Senanayake CH. Rhodium-Catalyzed Asymmetric Allenylation of Sulfonylimines and Application to the Stereospecific Allylic Allenylation Advanced Synthesis and Catalysis. 358: 3062-3068. DOI: 10.1002/Adsc.201600686 |
0.468 |
|
| 2016 |
Wu JP, Saha AK, Haddad N, Busacca CA, Lorenz JC, Lee H, Senanayake CH. Simple N-Heterocyclic Carbenes as Ligands in Ullmann-Type Ether and Thioether Formations Advanced Synthesis and Catalysis. 358: 1924-1928. DOI: 10.1002/Adsc.201600316 |
0.462 |
|
| 2015 |
Chen PH, Sieber J, Senanayake CH, Dong G. Rh-catalyzed Reagent-Free Ring Expansion of Cyclobutenones and Benzocyclobutenones. Chemical Science. 6: 5440-5445. PMID 28042458 DOI: 10.1039/C5Sc01875G |
0.402 |
|
| 2015 |
Sieber JD, Qu B, Rodriguez S, Haddad N, Grinberg N, Lee H, Song JJ, Yee NK, Senanayake CH. Synthesis of P-Chiral Dihydrobenzooxaphospholes Through Negishi Cross-Coupling. The Journal of Organic Chemistry. PMID 26671422 DOI: 10.1021/Acs.Joc.5B02649 |
0.46 |
|
| 2015 |
Marsini MA, Reeves JT, Desrosiers JN, Herbage MA, Savoie J, Li Z, Fandrick KR, Sader CA, McKibben B, Gao DA, Cui J, Gonnella NC, Lee H, Wei X, Roschangar F, ... ... Senanayake CH, et al. Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters. Organic Letters. PMID 26558319 DOI: 10.1021/Acs.Orglett.5B02838 |
0.418 |
|
| 2015 |
Malapit CA, Reeves JT, Busacca CA, Howell AR, Senanayake CH. Rhodium-Catalyzed Transnitrilation of Aryl Boronic Acids with Dimethylmalononitrile. Angewandte Chemie (International Ed. in English). PMID 26483150 DOI: 10.1002/Anie.201508122 |
0.452 |
|
| 2015 |
Latli B, Reeves JT, Tan Z, Hrapchak M, Song JJ, Busacca CB, Senanayake CH. Synthesis of two potent glucocorticoid receptor agonists labeled with carbon-14 and stable isotopes. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26391408 DOI: 10.1002/Jlcr.3349 |
0.39 |
|
| 2015 |
Latli B, Hrapchak M, Gao JJ, Busacca CA, Senanayake CH. A novel five-lipoxygenase activity protein inhibitor labeled with carbon-14 and deuterium. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 390-4. PMID 26190342 DOI: 10.1002/Jlcr.3319 |
0.37 |
|
| 2015 |
Reeves JT, Malapit CA, Buono FG, Sidhu KP, Marsini MA, Sader CA, Fandrick KR, Busacca CA, Senanayake CH. Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis. Journal of the American Chemical Society. 137: 9481-8. PMID 26151426 DOI: 10.1021/Jacs.5B06136 |
0.449 |
|
| 2015 |
Latli B, Hrapchak M, Chevliakov M, Li G, Campbell S, Busacca CA, Senanayake CH. Synthesis of deleobuvir, a potent hepatitis C virus polymerase inhibitor, and its major metabolites labeled with carbon-13 and carbon-14. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 250-60. PMID 25964148 DOI: 10.1002/Jlcr.3294 |
0.322 |
|
| 2015 |
Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, ... ... Senanayake CH, et al. Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor. Angewandte Chemie (International Ed. in English). 54: 7144-8. PMID 25939331 DOI: 10.1002/Anie.201501575 |
0.432 |
|
| 2015 |
Reeves JT, Visco MD, Marsini MA, Grinberg N, Busacca CA, Mattson AE, Senanayake CH. A General Method for Imine Formation Using B(OCH2CF3)3. Organic Letters. 17: 2442-5. PMID 25906082 DOI: 10.1021/Acs.Orglett.5B00949 |
0.332 |
|
| 2015 |
Han ZS, Zhang L, Xu Y, Sieber JD, Marsini MA, Li Z, Reeves JT, Fandrick KR, Patel ND, Desrosiers JN, Qu B, Chen A, Rudzinski DM, Samankumara LP, Ma S, ... ... Senanayake CH, et al. Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design. Angewandte Chemie (International Ed. in English). 54: 5474-7. PMID 25757595 DOI: 10.1002/Anie.201500350 |
0.452 |
|
| 2015 |
Fandrick KR, Mulder JA, Patel ND, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Desrosiers JN, Zeng X, Rodriguez S, Ma S, Qu B, ... ... Senanayake CH, et al. Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor. The Journal of Organic Chemistry. 80: 1651-60. PMID 25562342 DOI: 10.1021/Jo502550H |
0.452 |
|
| 2015 |
Snieckus V, Tsai A, Fandrick DR, Sanyal S, Kaloko J, Mulder JA, Wang Y, Wu L, Lee H, Roschangar F, Hoffmann M, Senanayake CH. Selective Synthesis of 3- or 5-Substituted Aminopyrazoles Synfacts. 11: 919-919. DOI: 10.1055/S-0035-1560156 |
0.397 |
|
| 2015 |
Haddad N, Qu B, Lee H, Lorenz J, Varsolona R, Kapadia S, Sarvestani M, Feng X, Busacca CA, Hebrault D, Rea S, Schellekens L, Senanayake CH. PAT application in the expedited development of a three-step, one-stage synthesis of the dipeptide intermediate of HCV protease inhibitor faldaprevir Organic Process Research and Development. 19: 132-138. DOI: 10.1021/Op400285Y |
0.336 |
|
| 2015 |
Lorenc C, Reeves JT, Busacca CA, Senanayake CH. Acid mediated deprotection of N-isopropyl tertiary amides Tetrahedron Letters. 56: 1280-1282. DOI: 10.1016/J.Tetlet.2015.01.161 |
0.337 |
|
| 2015 |
Zeng X, Wei X, Song JJ, Sarvestani M, Fandrick DR, Qu B, Rodríguez S, Sieber JD, Desrosiers JN, Yee NK, Roschangar F, Senanayake CH. Development of a Practical Sequence for Difluoromethylation of 2-Bromopyridines via Copper-Mediated Reductive Coupling and Decarboxylation Asian Journal of Organic Chemistry. DOI: 10.1002/Ajoc.201500349 |
0.367 |
|
| 2015 |
Malapit CA, Visco MD, Reeves JT, Busacca CA, Howell AR, Senanayake CH. Nickel- or Cobalt-Catalyzed Cross-Coupling of Arylsulfonic Acid Salts with Grignard Reagents Advanced Synthesis and Catalysis. 357: 2199-2204. DOI: 10.1002/Adsc.201500304 |
0.38 |
|
| 2014 |
Qu B, Samankumara LP, Ma S, Fandrick KR, Desrosiers JN, Rodriguez S, Li Z, Haddad N, Han ZS, McKellop K, Pennino S, Grinberg N, Gonnella NC, Song JJ, Senanayake CH. A mild dihydrobenzooxaphosphole oxazoline/iridium catalytic system for asymmetric hydrogenation of unfunctionalized dialins. Angewandte Chemie (International Ed. in English). 53: 14428-32. PMID 25385009 DOI: 10.1002/Anie.201408929 |
0.401 |
|
| 2014 |
Hrapchak M, Latli B, Wang XJ, Lee H, Campbell S, Song JJ, Senanayake CH. Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 687-94. PMID 25332189 DOI: 10.1002/Jlcr.3240 |
0.331 |
|
| 2014 |
Sieber JD, Chennamadhavuni D, Fandrick KR, Qu B, Han ZS, Savoie J, Ma S, Samankumara LP, Grinberg N, Lee H, Song JJ, Senanayake CH. Development of new P-chiral P,π-dihydrobenzooxaphosphole hybrid ligands for asymmetric catalysis. Organic Letters. 16: 5494-7. PMID 25298301 DOI: 10.1021/Ol5027798 |
0.368 |
|
| 2014 |
Busacca CA, Milligan JA, Rattanangkool E, Ramavarapu C, Chen A, Saha AK, Li Z, Lee H, Geib SJ, Wang G, Senanayake CH, Wipf P. Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes. The Journal of Organic Chemistry. 79: 9878-87. PMID 25271367 DOI: 10.1021/Jo501841S |
0.43 |
|
| 2014 |
Zeng X, Gao JJ, Song JJ, Ma S, Desrosiers JN, Mulder JA, Rodriguez S, Herbage MA, Haddad N, Qu B, Fandrick KR, Grinberg N, Lee H, Wei X, Yee NK, ... Senanayake CH, et al. Remarkable enhancement of enantioselectivity in the asymmetric conjugate addition of dimethylzinc to (Z)-nitroalkenes with a catalytic [(MeCN)₄Cu]PF₆-Hoveyda ligand complex. Angewandte Chemie (International Ed. in English). 53: 12153-7. PMID 25225113 DOI: 10.1002/Anie.201406247 |
0.439 |
|
| 2014 |
Ma S, Tsui HW, Spinelli E, Bussaca CA, Franses EI, Wang NH, Wu L, Lee H, Senanayake C, Yee N, Gonella N, Fandrick K, Grinberg N. Insights into chromatographic enantiomeric separation of allenes on cellulose carbamate stationary phase. Journal of Chromatography. A. 1362: 119-28. PMID 25193169 DOI: 10.1016/J.Chroma.2014.08.032 |
0.318 |
|
| 2014 |
Fandrick KR, Patel ND, Mulder JA, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Fandrick DR, Ma S, Grinberg N, Lee H, Busacca CA, ... ... Senanayake CH, et al. Addressing the configuration stability of lithiated secondary benzylic carbamates for the development of a noncryogenic stereospecific boronate rearrangement. Organic Letters. 16: 4360-3. PMID 25153850 DOI: 10.1021/Ol502060C |
0.386 |
|
| 2014 |
Zhang Y, Lu BZ, Li G, Rodriguez S, Tan J, Wei HX, Liu J, Roschangar F, Ding F, Zhao W, Qu B, Reeves D, Grinberg N, Lee H, Heckmann G, ... ... Senanayake CH, et al. A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127): application of a one-pot borylation-Suzuki coupling reaction. Organic Letters. 16: 4558-61. PMID 25105303 DOI: 10.1021/Ol5021114 |
0.398 |
|
| 2014 |
Han ZS, Xu Y, Fandrick DR, Rodriguez S, Li Z, Qu B, Gonnella NC, Sanyal S, Reeves JT, Ma S, Grinberg N, Haddad N, Krishnamurthy D, Song JJ, Yee NK, ... ... Senanayake CH, et al. Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor. Organic Letters. 16: 4142-5. PMID 25084526 DOI: 10.1021/Ol501833G |
0.475 |
|
| 2014 |
Wang XJ, Zhang L, Byrne D, Nummy L, Weber D, Krishnamurthy D, Yee N, Senanayake CH. Efficient synthesis of Empagliflozin, an inhibitor of SGLT-2, utilizing an AlCl3-promoted silane reduction of a β-glycopyranoside. Organic Letters. 16: 4090-3. PMID 25061799 DOI: 10.1021/Ol501755H |
0.402 |
|
| 2014 |
Reeves JT, Lorenc C, Camara K, Li Z, Lee H, Busacca CA, Senanayake CH. Carbamoyl anion addition to nitrones. The Journal of Organic Chemistry. 79: 5895-902. PMID 24870397 DOI: 10.1021/Jo500848A |
0.384 |
|
| 2014 |
Fandrick DR, Reinhardt D, Desrosiers JN, Sanyal S, Fandrick KR, Ma S, Grinberg N, Lee H, Song JJ, Senanayake CH. General and rapid pyrimidine condensation by addressing the rate limiting aromatization. Organic Letters. 16: 2834-7. PMID 24818876 DOI: 10.1021/Ol500886A |
0.307 |
|
| 2014 |
Latli B, Hrapchak M, Gorys V, Llinàs-Brunet M, Campbell SS, Song J, Senanayake CH. Hepatitis C virus serine protease: Synthesis of radioactive and stable isotope-labeled potent inhibitors Journal of Labelled Compounds and Radiopharmaceuticals. 57: 350-357. PMID 24700697 DOI: 10.1002/Jlcr.3187 |
0.363 |
|
| 2014 |
Desrosiers JN, Kelly CB, Fandrick DR, Nummy L, Campbell SJ, Wei X, Sarvestani M, Lee H, Sienkiewicz A, Sanyal S, Zeng X, Grinberg N, Ma S, Song JJ, Senanayake CH. A scalable and regioselective synthesis of 2-difluoromethyl pyridines from commodity chemicals. Organic Letters. 16: 1724-7. PMID 24601851 DOI: 10.1021/Ol500402E |
0.361 |
|
| 2014 |
Reeves JT, Camara K, Han ZS, Xu Y, Lee H, Busacca CA, Senanayake CH. The reaction of Grignard reagents with Bunte salts: a thiol-free synthesis of sulfides. Organic Letters. 16: 1196-9. PMID 24512478 DOI: 10.1021/Ol500067F |
0.437 |
|
| 2014 |
Qu B, Samankumara LP, Savoie J, Fandrick DR, Haddad N, Wei X, Ma S, Lee H, Rodriguez S, Busacca CA, Yee NK, Song JJ, Senanayake CH. Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes. The Journal of Organic Chemistry. 79: 993-1000. PMID 24410322 DOI: 10.1021/Jo4024864 |
0.469 |
|
| 2014 |
Xu G, Fu W, Liu G, Senanayake CH, Tang W. Efficient syntheses of korupensamines A, B and michellamine B by asymmetric Suzuki-Miyaura coupling reactions. Journal of the American Chemical Society. 136: 570-3. PMID 24147559 DOI: 10.1021/Ja409669R |
0.474 |
|
| 2014 |
Rodríguez S, Qu B, Fandrick KR, Buono F, Haddad N, Xu Y, Herbage MA, Zeng X, Ma S, Grinberg N, Lee H, Han ZS, Yee NK, Senanayake CH. Asymmetric Hydrogenation of Ketones by Ruthenium Catalysis Synfacts. 10: 506-506. DOI: 10.1055/S-0033-1341142 |
0.322 |
|
| 2014 |
Buono FG, Eriksson MC, Yang BS, Kapadia SR, Lee H, Brazzillo J, Lorenz JC, Nummy L, Busacca CA, Yee N, Senanayake C. Development of multikilogram continuous flow cyclopropanation of N -benzylmaleimide through kinetic analysis Organic Process Research and Development. 18: 1527-1534. DOI: 10.1021/Op500263M |
0.408 |
|
| 2014 |
Reeves JT, Tan Z, Reeves DC, Song JJ, Han ZS, Xu Y, Tang W, Yang BS, Razavi H, Harcken C, Kuzmich D, Mahaney PE, Lee H, Busacca CA, Senanayake CH. Development of an enantioselective hydrogenation route to (S)-1-(2-(methylsulfonyl)pyridin-4-yl)propan-1-amine Organic Process Research and Development. 18: 904-911. DOI: 10.1021/Op5001513 |
0.472 |
|
| 2014 |
Reeves JT, Han ZS, Goyal N, Lee H, Busacca CA, Senanayake CH. Cationic triazinium heterocycles by intramolecular NN bond formation Tetrahedron Letters. 55: 2492-2494. DOI: 10.1016/J.Tetlet.2014.03.009 |
0.409 |
|
| 2014 |
Frutos RP, Rodriguez S, Patel ND, Reeves D, Tampone T, Senanayake CH. A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors Asian Journal of Organic Chemistry. 3: 769-772. DOI: 10.1002/Ajoc.201400002 |
0.375 |
|
| 2014 |
Rodríguez S, Qu B, Fandrick KR, Buono F, Haddad N, Xu Y, Herbage MA, Zeng X, Ma S, Grinberg N, Lee H, Han ZS, Yee NK, Senanayake CH. Amine-tunable ruthenium catalysts for asymmetric reduction of ketones Advanced Synthesis and Catalysis. 356: 301-307. DOI: 10.1002/Adsc.201300727 |
0.414 |
|
| 2014 |
Busacca CA, Eriksson MC, Haddad N, Han ZS, Lorenz JC, Qu B, Zeng X, Senanayake CH. Practical Synthesis of Di-tert-Butyl-Phosphinoferrocene Organic Syntheses. 316-326. DOI: 10.1002/0471264229.Os090.30 |
0.439 |
|
| 2014 |
Tang W, Patel ND, Capacci AG, Wei X, Yee NK, Senanayake CH. Synthesis of N‐Acetyl Enamides by Reductive Acetylation of Oximes Mediated with Iron(II) Acetate: N‐(1‐(4‐Bromophenyl)vinyl)acetamide Organic Syntheses. 62-73. DOI: 10.1002/0471264229.Os090.06 |
0.304 |
|
| 2014 |
Reeves JT, Tan Z, Fandrick DR, Song JJ, Yee NK, Senanayake CH. Synthesis of Trifluoromethyl Ketones from Carboxylic Acids: 4‐(3,4‐Dibromophenyl)‐1,1,1‐trifluoro‐4‐methylpentan‐2‐one Organic Syntheses. 210-219. DOI: 10.1002/0471264229.Os089.21 |
0.401 |
|
| 2013 |
Han ZS, Herbage MA, Mangunuru HP, Xu Y, Zhang L, Reeves JT, Sieber JD, Li Z, DeCroos P, Zhang Y, Li G, Li N, Ma S, Grinberg N, Wang X, ... ... Senanayake CH, et al. Design and synthesis of chiral oxathiozinone scaffolds: efficient synthesis of hindered enantiopure sulfinamides and sulfinyl ketimines. Angewandte Chemie (International Ed. in English). 52: 6713-7. PMID 23677810 DOI: 10.1002/Anie.201301676 |
0.423 |
|
| 2013 |
Frutos RP, Wei X, Patel ND, Tampone TG, Mulder JA, Busacca CA, Senanayake CH. One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles. The Journal of Organic Chemistry. 78: 5800-3. PMID 23656541 DOI: 10.1021/Jo400720P |
0.421 |
|
| 2013 |
Zhang Y, Li N, Goyal N, Li G, Lee H, Lu BZ, Senanayake CH. Solvent-free methallylboration of ketones accelerated by tert-alcohols. The Journal of Organic Chemistry. 78: 5775-81. PMID 23634910 DOI: 10.1021/Jo4006574 |
0.315 |
|
| 2013 |
Reeves JT, Tan Z, Herbage MA, Han ZS, Marsini MA, Li Z, Li G, Xu Y, Fandrick KR, Gonnella NC, Campbell S, Ma S, Grinberg N, Lee H, Lu BZ, ... Senanayake CH, et al. Carbamoyl anion addition to N-sulfinyl imines: highly diastereoselective synthesis of α-amino amides. Journal of the American Chemical Society. 135: 5565-8. PMID 23557536 DOI: 10.1021/Ja402647M |
0.44 |
|
| 2013 |
Fandrick DR, Reeves JT, Bakonyi JM, Nyalapatla PR, Tan Z, Niemeier O, Akalay D, Fandrick KR, Wohlleben W, Ollenberger S, Song JJ, Sun X, Qu B, Haddad N, Sanyal S, ... ... Senanayake CH, et al. Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate. The Journal of Organic Chemistry. 78: 3592-615. PMID 23544787 DOI: 10.1021/Jo400080Y |
0.466 |
|
| 2013 |
Reeves JT, Fandrick DR, Tan Z, Song JJ, Rodriguez S, Qu B, Kim S, Niemeier O, Li Z, Byrne D, Campbell S, Chitroda A, DeCroos P, Fachinger T, Fuchs V, ... ... Senanayake CH, et al. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4. The Journal of Organic Chemistry. 78: 3616-35. PMID 23544738 DOI: 10.1021/Jo400079Z |
0.483 |
|
| 2013 |
Lu BZ, Wei HX, Zhang Y, Zhao W, Dufour M, Li G, Farina V, Senanayake CH. One-pot and regiospecific synthesis of 2,3-disubstituted indoles from 2-bromoanilides via consecutive palladium-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination. The Journal of Organic Chemistry. 78: 4558-62. PMID 23544431 DOI: 10.1021/Jo302679F |
0.469 |
|
| 2013 |
Zhang Y, Li N, Qu B, Ma S, Lee H, Gonnella NC, Gao J, Li W, Tan Z, Reeves JT, Wang J, Lorenz JC, Li G, Reeves DC, Premasiri A, ... ... Senanayake CH, et al. Asymmetric methallylation of ketones catalyzed by a highly active organocatalyst 3,3'-F2-BINOL. Organic Letters. 15: 1710-3. PMID 23527954 DOI: 10.1021/Ol400498A |
0.328 |
|
| 2013 |
Fandrick KR, Ogikubo J, Fandrick DR, Patel ND, Saha J, Lee H, Ma S, Grinberg N, Busacca CA, Senanayake CH. Copper-catalyst-controlled site-selective allenylation of ketones and aldehydes with propargyl boronates. Organic Letters. 15: 1214-7. PMID 23438081 DOI: 10.1021/Ol400124F |
0.331 |
|
| 2013 |
Busacca CA, Qu B, Farber E, Haddad N, Gr?t N, Saha AK, Eriksson MC, Wu JP, Fandrick KR, Han S, Grinberg N, Ma S, Lee H, Li Z, Spinelli M, ... ... Senanayake CH, et al. Hydrophosphination of propargylic alcohols and amines with phosphine boranes. Organic Letters. 15: 1132-5. PMID 23427869 DOI: 10.1021/Ol400309Y |
0.368 |
|
| 2013 |
Busacca CA, Qu B, Farber E, Haddad N, Gr?t N, Saha AK, Eriksson MC, Wu JP, Fandrick KR, Han S, Grinberg N, Ma S, Lee H, Li Z, Spinelli M, ... ... Senanayake CH, et al. [2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives. Organic Letters. 15: 1136-9. PMID 23427861 DOI: 10.1021/Ol400310H |
0.319 |
|
| 2013 |
Wei X, Shu C, Haddad N, Zeng X, Patel ND, Tan Z, Liu J, Lee H, Shen S, Campbell S, Varsolona RJ, Busacca CA, Hossain A, Yee NK, Senanayake CH. A highly convergent and efficient synthesis of a macrocyclic hepatitis C virus protease inhibitor BI 201302. Organic Letters. 15: 1016-9. PMID 23406520 DOI: 10.1021/Ol303498M |
0.378 |
|
| 2013 |
Han ZS, Goyal N, Herbage MA, Sieber JD, Qu B, Xu Y, Li Z, Reeves JT, Desrosiers JN, Ma S, Grinberg N, Lee H, Mangunuru HP, Zhang Y, Krishnamurthy D, ... ... Senanayake CH, et al. Efficient asymmetric synthesis of P-chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents. Journal of the American Chemical Society. 135: 2474-7. PMID 23369026 DOI: 10.1021/Ja312352P |
0.384 |
|
| 2013 |
Zhao Q, Li C, Senanayake CH, Tang W. An efficient method for sterically demanding Suzuki-Miyaura coupling reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 2261-5. PMID 23296637 DOI: 10.1002/Chem.201203898 |
0.405 |
|
| 2013 |
Latli B, Haddad N, Hrapchak M, Wei X, Tang W, Song JJ, Senanayake CH. Sodium-proton exchanger isoform-1: synthesis of a potent inhibitor labeled with deuterium and carbon-14. Current Radiopharmaceuticals. 6: 7-11. PMID 23256768 DOI: 10.2174/1874471011306010002 |
0.314 |
|
| 2013 |
Lu BZ, Li G, Rodriguez S, Liu J, Eriksson MC, Tan Z, Song JJ, Yee N, Farina V, Senanayake CH. Development of a practical synthesis of 4-[6-(morpholinomethyl)-pyridin-3- yl]naphthalen-1-amine, a key intermediate for the synthesis of birb 1017, a potent p38 map kinase inhibitor Synlett. 24: 317-322. DOI: 10.1055/S-0032-1317790 |
0.404 |
|
| 2013 |
Mulder JA, Frutos RP, Patel ND, Qu B, Sun X, Tampone TG, Gao J, Sarvestani M, Eriksson MC, Haddad N, Shen S, Song JJ, Senanayake CH. Development of a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on kilogram scale Organic Process Research and Development. 17: 940-945. DOI: 10.1021/Op400061W |
0.352 |
|
| 2013 |
Li W, Rodriguez S, Duran A, Sun X, Tang W, Premasiri A, Wang J, Sidhu K, Patel ND, Savoie J, Qu B, Lee H, Haddad N, Lorenz JC, Nummy L, ... ... Senanayake CH, et al. The P-chiral phosphane ligand (MeO-BIBOP) for efficient and practical large-scale Rh-catalyzed asymmetric hydrogenation of N-acetyl enamides with high TONs Organic Process Research and Development. 17: 1061-1065. DOI: 10.1021/Op400055Z |
0.401 |
|
| 2013 |
Tang W, Patel ND, Wei X, Byrne D, Chitroda A, Narayanan B, Sienkiewicz A, Nummy LJ, Sarvestani M, Ma S, Grinberg N, Lee H, Kim S, Li Z, Spinelli E, ... ... Senanayake CH, et al. Synthesis of a sodium-hydrogen exchange type 1 inhibitor: An efficient Cu-catalyzed conjugated addition of a Grignard reagent to an acetyl pyridinium salt Organic Process Research and Development. 17: 382-389. DOI: 10.1021/Op300331B |
0.478 |
|
| 2013 |
Ma S, Grinberg N, Haddad N, Rodriguez S, Busacca CA, Fandrick K, Lee H, Song JJ, Yee N, Krishnamurthy D, Senanayake CH, Wang J, Trenck J, Mendonsa S, Claise PR, et al. Heart-cutting two-dimensional ultrahigh-pressure liquid chromatography for process development: Asymmetric reaction monitoring Organic Process Research and Development. 17: 806-810. DOI: 10.1021/Op300266J |
0.335 |
|
| 2013 |
Reeves JT, Tan Z, Lu BZ, Senanayake CH. Copper-catalyzed annulation of 2-formylazoles with aminoiodopyrazoles: Synthesis of new heterocyclic ring systems Journal of Heterocyclic Chemistry. 50: 680-683. DOI: 10.1002/Jhet.1500 |
0.426 |
|
| 2013 |
Busacca CA, Qu B, Grět N, Fandrick KR, Saha AK, Marsini M, Reeves D, Haddad N, Eriksson M, Wu JP, Grinberg N, Lee H, Li Z, Lu B, Chen D, ... ... Senanayake CH, et al. Tuning the peri effect for enantioselectivity: Asymmetric hydrogenation of unfunctionalized olefins with the BIPI ligands Advanced Synthesis and Catalysis. 355: 1455-1463. DOI: 10.1002/Adsc.201201104 |
0.349 |
|
| 2013 |
Reeves JT, Tan Z, Marsini MA, Han ZS, Xu Y, Reeves DC, Lee H, Lu BZ, Senanayake CH. A practical procedure for reduction of primary, secondary and tertiary amides to amines Advanced Synthesis and Catalysis. 355: 47-52. DOI: 10.1002/Adsc.201200835 |
0.385 |
|
| 2012 |
Latli B, Hrapchak M, Lorenz JC, Busacca CA, Senanayake C. Synthesis of a potent cathepsin s inhibitor labeled with deuterium and carbon-14. Current Radiopharmaceuticals. 5: 314-7. PMID 22724423 DOI: 10.2174/1874471011205040314 |
0.411 |
|
| 2012 |
Tang W, Patel ND, Xu G, Xu X, Savoie J, Ma S, Hao MH, Keshipeddy S, Capacci AG, Wei X, Zhang Y, Gao JJ, Li W, Rodriguez S, Lu BZ, ... ... Senanayake CH, et al. Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions. Organic Letters. 14: 2258-61. PMID 22497425 DOI: 10.1021/Ol300659D |
0.481 |
|
| 2012 |
Reeves JT, Tan Z, Han ZS, Li G, Zhang Y, Xu Y, Reeves DC, Gonnella NC, Ma S, Lee H, Lu BZ, Senanayake CH. Direct titanium-mediated conversion of ketones into enamides with ammonia and acetic anhydride. Angewandte Chemie (International Ed. in English). 51: 1400-4. PMID 22294356 DOI: 10.1002/Anie.201107601 |
0.376 |
|
| 2012 |
Zhang Y, Chitale S, Goyal N, Li G, Han ZS, Shen S, Ma S, Grinberg N, Lee H, Lu BZ, Senanayake CH. Asymmetric synthesis of sulfinamides using (-)-quinine as chiral auxiliary. The Journal of Organic Chemistry. 77: 690-5. PMID 22126231 DOI: 10.1021/Jo201825B |
0.487 |
|
| 2012 |
Zhang L, Li Z, Wang XJ, Yee N, Senanayake CH. Regioselective synthesis of polysubstituted N 2-alkyl/aryl-1,2,3-triazoles via 4-bromo-5-iodo-1,2,3-triazole Synlett. 23: 1052-1056. DOI: 10.1055/S-0031-1290770 |
0.479 |
|
| 2012 |
Busacca CA, Lorenz JC, Saha AK, Cheekoori S, Haddad N, Reeves D, Lee H, Li Z, Rodriguez S, Senanayake CH. Development of the BIPI ligands for asymmetric hydrogenation Catalysis Science and Technology. 2: 2083-2089. DOI: 10.1039/C2Cy20337E |
0.373 |
|
| 2012 |
Li W, Gao JJ, Lorenz JC, Xu J, Johnson J, Ma S, Lee H, Grinberg N, Busacca CA, Lu B, Senanayake CH. Process development and pilot-plant synthesis of (S)-tert-butyl 1-oxo-1-(1-(pyridin-2-yl)cyclopropylamino)propan-2-ylcarbamate: Studies on the scale-up of Kulinkovich-Szymoniak cyclopropanation Organic Process Research and Development. 16: 836-839. DOI: 10.1021/Op300059B |
0.449 |
|
| 2012 |
Wang XJ, Zhang L, Sun X, Lee H, Krishnamurthy D, O'Meara JA, Landry S, Yoakim C, Simoneau B, Yee NK, Senanayake CH. Practical synthesis of a benzophenone-based NNRT inhibitor of HIV-1 Organic Process Research and Development. 16: 561-566. DOI: 10.1021/Op200301H |
0.443 |
|
| 2012 |
Fandrick DR, Roschangar F, Kim C, Hahm BJ, Cha MH, Kim HY, Yoo G, Kim T, Reeves JT, Song JJ, Tan Z, Qu B, Haddad N, Shen S, Grinberg N, ... ... Senanayake CH, et al. Preparative synthesis via continuous flow of 4,4,5,5-tetramethyl-2-(3- trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane: A general propargylation reagent Organic Process Research and Development. 16: 1131-1140. DOI: 10.1021/Op200180T |
0.339 |
|
| 2012 |
Qu B, Haddad N, Rodriguez S, Lee H, Ma S, Zeng X, Reeves DC, Sidhu KPS, Lorenz JC, Grinberg N, Busacca CA, Krishnamurthy D, Senanayake CH. Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl 3 Tetrahedron Letters. 53: 1982-1986. DOI: 10.1016/J.Tetlet.2012.02.023 |
0.442 |
|
| 2012 |
Busacca CA, Wei X, Haddad N, Kapadia S, Lorenz JC, Saha AK, Varsolona RJ, Berkenbusch T, Campbell SC, Farina V, Feng X, Gonnella NC, Grinberg N, Jones PJ, Lee H, ... ... Senanayake CH, et al. Practical large-scale synthesis of the hepatitis C virus protease inhibitor BI201335 Asian Journal of Organic Chemistry. 1: 80-89. DOI: 10.1002/Ajoc.201200014 |
0.369 |
|
| 2011 |
Fandrick DR, Saha J, Fandrick KR, Sanyal S, Ogikubo J, Lee H, Roschangar F, Song JJ, Senanayake CH. Zinc-catalyzed allenylations of aldehydes and ketones. Organic Letters. 13: 5616-9. PMID 21942658 DOI: 10.1021/Ol202343C |
0.42 |
|
| 2011 |
Zhang Y, Gao J, Li W, Lee H, Lu BZ, Senanayake CH. Synthesis of 8-arylquinolines via one-pot Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling. The Journal of Organic Chemistry. 76: 6394-400. PMID 21662971 DOI: 10.1021/Jo200904G |
0.431 |
|
| 2011 |
Fandrick KR, Fandrick DR, Reeves JT, Gao J, Ma S, Li W, Lee H, Grinberg N, Lu B, Senanayake CH. A general copper-BINAP-catalyzed asymmetric propargylation of ketones with propargyl boronates. Journal of the American Chemical Society. 133: 10332-5. PMID 21639096 DOI: 10.1021/Ja2028958 |
0.415 |
|
| 2011 |
Han ZS, Meyer AM, Xu Y, Zhang Y, Busch R, Shen S, Grinberg N, Lu BZ, Krishnamurthy D, Senanayake CH. Enantioselective synthesis of diverse sulfinamides and sulfinylferrocenes from phenylglycine-derived chiral sulfinyl transfer agent. The Journal of Organic Chemistry. 76: 5480-4. PMID 21598997 DOI: 10.1021/Jo200715C |
0.445 |
|
| 2011 |
Reeves DC, Rodriguez S, Lee H, Haddad N, Krishnamurthy D, Senanayake CH. Palladium catalyzed alkoxy- and aminocarbonylation of vinyl tosylates. Organic Letters. 13: 2495-7. PMID 21488632 DOI: 10.1021/Ol200744S |
0.454 |
|
| 2011 |
Tang W, Keshipeddy S, Zhang Y, Wei X, Savoie J, Patel ND, Yee NK, Senanayake CH. Efficient monophosphorus ligands for palladium-catalyzed Miyaura borylation. Organic Letters. 13: 1366-9. PMID 21319836 DOI: 10.1021/Ol2000556 |
0.414 |
|
| 2011 |
Zhang Y, Gao J, Li W, Lee H, Lu BZ, Senanayake CH. Pd-Catalyzed One-Pot Process to Yield 8-Arylquinolines Synfacts. 2011: 1113-1113. DOI: 10.1055/S-0030-1261068 |
0.308 |
|
| 2011 |
Haddad N, Qu B, Rodriguez S, Veen Lvd, Reeves DC, Gonnella NC, Lee H, Grinberg N, Ma SL, Krishnamurthy D, Wunberg T, Senanayake CH. Asymmetric Hydrogenation of Heterocyclic Ketone-Derived Hydrazones Synfacts. 2011: 1085-1085. DOI: 10.1055/S-0030-1261067 |
0.349 |
|
| 2011 |
Fandrick KR, Fandrick DR, Reeves JT, Gao J, Ma SL, Li WJ, Lee H, Grinberg N, Lu B, Senanayake CH. Cu-Catalyzed Asymmetric Propargylation of Ketones Synfacts. 2011: 1100-1100. DOI: 10.1055/S-0030-1261065 |
0.322 |
|
| 2011 |
Frutos RP, Tampone T, Mulder JA, Xu Y, Reeves D, Wang X-, Zhang L, Krishnamurthy D, Senanayake CH. A Boronic Acid Catalyzed Route to Imidazoles. Synthesis ofLFA-1 Antagonists Synfacts. 2011: 603-603. DOI: 10.1055/S-0030-1260450 |
0.415 |
|
| 2011 |
Wang XJ, Frutos RP, Zhang L, Sun X, Xu Y, Wirth T, Nicola T, Nummy LJ, Krishnamurthy D, Busacca CA, Yee N, Senanayake CH. Asymmetric synthesis of LFA-1 inhibitor BIRT2584 on metric ton scale Organic Process Research and Development. 15: 1185-1191. DOI: 10.1021/Op200175T |
0.401 |
|
| 2011 |
Tang W, Wei X, Yee NK, Patel N, Lee H, Savoie J, Senanayake CH. A practical asymmetric synthesis of isopropyl (1 R,2 S)-dehydrocoronamate Organic Process Research and Development. 15: 1207-1211. DOI: 10.1021/Op200038Y |
0.376 |
|
| 2011 |
Haddad N, Qu B, Rodriguez S, Van Der Veen L, Reeves DC, Gonnella NC, Lee H, Grinberg N, Ma S, Krishnamurthy D, Wunberg T, Senanayake CH. Catalytic asymmetric hydrogenation of heterocyclic ketone-derived hydrazones, pronounced solvent effect on the inversion of configuration Tetrahedron Letters. 52: 3718-3722. DOI: 10.1016/J.Tetlet.2011.05.017 |
0.397 |
|
| 2011 |
Frutos RP, Tampone T, Mulder JA, Xu Y, Reeves D, Wang XJ, Zhang L, Krishnamurthy D, Senanayake CH. A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists Tetrahedron Letters. 52: 2465-2467. DOI: 10.1016/J.Tetlet.2011.03.007 |
0.411 |
|
| 2011 |
Han Z, Busch R, Fandrick KR, Meyer A, Xu Y, Krishnamurthy DK, Senanayake CH. Asymmetric synthesis of diverse α,α-diarylmethylamines via aryl Grignard additions to chiral N-2,4,6-triisopropylbenzenesulfinylimines Tetrahedron. 67: 7035-7041. DOI: 10.1016/J.Tet.2011.07.019 |
0.472 |
|
| 2011 |
Latli B, Hrapchak M, Xu Y, Qiu F, Krishnamurthy D, Senanayake CH. Synthesis of a highly potent leukocyte function-associated antigen-1 antagonist and its metabolite labeled with stable isotopes and carbon-14, part 2 Journal of Labelled Compounds and Radiopharmaceuticals. 54: 799-808. DOI: 10.1002/Jlcr.1934 |
0.356 |
|
| 2011 |
Latli B, Byrne D, Nummy L, Krishnamurthy D, Senanayake CH. Synthesis of potent lymphocyte function-associated antigen-1 inhibitors labeled with carbon-14 and deuterium, part 1 Journal of Labelled Compounds and Radiopharmaceuticals. 54: 763-768. DOI: 10.1002/Jlcr.1920 |
0.384 |
|
| 2011 |
Latli B, Hrapchak M, Seetharama R, Krishnamurthy D, Senanayake CH. Chemical synthesis of allyl-[13C6]-glucuronate Journal of Labelled Compounds and Radiopharmaceuticals. 54: 337-339. DOI: 10.1002/Jlcr.1875 |
0.379 |
|
| 2011 |
Li W, Gao JJ, Zhang Y, Tang W, Lee H, Fandrick KR, Lu B, Senanayake CH. A mild palladium-catalyzed Suzuki coupling reaction of quinoline carboxylates with boronic acids Advanced Synthesis and Catalysis. 353: 1671-1675. DOI: 10.1002/Adsc.201100141 |
0.442 |
|
| 2011 |
Rodriguez S, Qu B, Haddad N, Reeves DC, Tang W, Lee H, Krishnamurthy D, Senanayake CH. Oxaphosphole-based monophosphorus ligands for palladium-catalyzed amination reactions Advanced Synthesis and Catalysis. 353: 533-537. DOI: 10.1002/Adsc.201000878 |
0.455 |
|
| 2010 |
Wang XJ, Zhang L, Krishnamurthy D, Senanayake CH, Wipf P. General solution to the synthesis of N-2-substituted 1,2,3-triazoles. Organic Letters. 12: 4632-5. PMID 20863126 DOI: 10.1021/Ol101965A |
0.399 |
|
| 2010 |
Wang XJ, Xu Y, Zhang L, Krishnamurthy D, Wirth T, Nicola T, Senanayake CH. Efficient synthesis of a small molecule, nonpeptide inhibitor of LFA-1. Organic Letters. 12: 4412-5. PMID 20831178 DOI: 10.1021/Ol101960X |
0.389 |
|
| 2010 |
Shu C, Sidhu K, Zhang L, Wang XJ, Krishnamurthy D, Senanayake CH. Palladium-catalyzed cross-coupling of cyclopropylmagnesium bromide with aryl bromides mediated by zinc halide additives. The Journal of Organic Chemistry. 75: 6677-80. PMID 20815373 DOI: 10.1021/Jo100983C |
0.447 |
|
| 2010 |
Reeves JT, Fandrick DR, Tan Z, Song JJ, Lee H, Yee NK, Senanayake CH. Room temperature palladium-catalyzed cross coupling of aryltrimethylammonium triflates with aryl Grignard reagents. Organic Letters. 12: 4388-91. PMID 20812668 DOI: 10.1021/Ol1018739 |
0.402 |
|
| 2010 |
Fandrick KR, Fandrick DR, Gao JJ, Reeves JT, Tan Z, Li W, Song JJ, Lu B, Yee NK, Senanayake CH. Mild and general zinc-alkoxide-catalyzed allylations of ketones with allyl pinacol boronates. Organic Letters. 12: 3748-51. PMID 20684564 DOI: 10.1021/Ol101301S |
0.462 |
|
| 2010 |
Tang W, Capacci AG, Wei X, Li W, White A, Patel ND, Savoie J, Gao JJ, Rodriguez S, Qu B, Haddad N, Lu BZ, Krishnamurthy D, Yee NK, Senanayake CH. A general and special catalyst for Suzuki-Miyaura coupling processes. Angewandte Chemie (International Ed. in English). 49: 5879-83. PMID 20632427 DOI: 10.1002/Anie.201002404 |
0.329 |
|
| 2010 |
Fandrick DR, Fandrick KR, Reeves JT, Tan Z, Tang W, Capacci AG, Rodriguez S, Song JJ, Lee H, Yee NK, Senanayake CH. Copper catalyzed asymmetric propargylation of aldehydes. Journal of the American Chemical Society. 132: 7600-1. PMID 20481453 DOI: 10.1021/Ja103312X |
0.454 |
|
| 2010 |
Tang W, Capacci AG, White A, Ma S, Rodriguez S, Qu B, Savoie J, Patel ND, Wei X, Haddad N, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH. Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation. Organic Letters. 12: 1104-7. PMID 20148522 DOI: 10.1021/Ol1000999 |
0.414 |
|
| 2010 |
Lorenz JC, Busacca CA, Feng X, Grinberg N, Haddad N, Johnson J, Kapadia S, Lee H, Saha A, Sarvestani M, Spinelli EM, Varsolona R, Wei X, Zeng X, Senanayake CH. Large-scale asymmetric synthesis of a cathepsin S inhibitor. The Journal of Organic Chemistry. 75: 1155-61. PMID 20102230 DOI: 10.1021/Jo9022809 |
0.451 |
|
| 2010 |
Fandrick DR, Johnson CS, Fandrick KR, Reeves JT, Tan Z, Lee H, Song JJ, Yee NK, Senanayake CH. Highly diastereoselective zinc-catalyzed propargylation of tert-butanesulfinyl imines. Organic Letters. 12: 748-51. PMID 20099813 DOI: 10.1021/Ol9028258 |
0.469 |
|
| 2010 |
Reeves JT, Fandrick DR, Tan Z, Song JJ, Lee H, Yee NK, Senanayake CH. Copper-catalyzed annulation of 2-formylazoles with o-aminoiodoarenes. The Journal of Organic Chemistry. 75: 992-4. PMID 20047297 DOI: 10.1021/Jo9025644 |
0.338 |
|
| 2010 |
Fandrick DR, Fandrick KR, Reeves JT, Tan Z, Johnson CS, Lee H, Song JJ, Yee NK, Senanayake CH. Zinc catalyzed and mediated propargylations with propargyl boronates. Organic Letters. 12: 88-91. PMID 19950953 DOI: 10.1021/Ol902457M |
0.423 |
|
| 2010 |
Tang W, Qu B, Capacci AG, Rodriguez S, Wei X, Haddad N, Narayanan B, Ma S, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH. Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. Organic Letters. 12: 176-9. PMID 19950894 DOI: 10.1021/Ol9025815 |
0.399 |
|
| 2010 |
Busacca CA, Campbell S, Gonnella NC, Senanayake CH. 1H and 13C NMR assignments of all three isomeric o-fluoronaphthaldehydes and three o-fluorophenanthrene aldehydes. Magnetic Resonance in Chemistry. 48: 74-79. PMID 19810003 DOI: 10.1002/Mrc.2523 |
0.336 |
|
| 2010 |
Shen S, Ma S, Lee H, Manolescu C, Grinberg M, Yee N, Senanayake C, Grinberg N. Hplc enantiomeric separation of aromatic amines using crown ether tetracarboxylic acid Journal of Liquid Chromatography and Related Technologies. 33: 153-166. DOI: 10.1080/10826070903439119 |
0.318 |
|
| 2010 |
Wang X-, Xu Y, Zhang L, Krishnamurthy D, Wirth T, Nicola T, Senanayake CH. Synthesis of an LFA-1 Inhibitor Synfacts. 2010: 1336-1336. DOI: 10.1055/S-0030-1258868 |
0.336 |
|
| 2010 |
Fandrick K, Fandrick D, Gao J, Reeves J, Tan Z, Li W, Song J, Lu B, Yee N, Senanayake C. Zinc Alkoxide Catalyzed Allylations of Ketones with Allyl Pinacol Boronates Synfacts. 2010: 1408-1408. DOI: 10.1055/S-0030-1258860 |
0.477 |
|
| 2010 |
Reeves J, Fandrick D, Tan Z, Song J, Lee H, Yee N, Senanayake C. Cross-Coupling of Aryltrimethylammonium Triflates with Aryl Grignard Reagents Synfacts. 2010: 1415-1415. DOI: 10.1055/S-0030-1258853 |
0.35 |
|
| 2010 |
Tang W, Capacci A, Wei X, Li W, White A, Patel N, Savoie J, Gao J, Rodriguez S, Qu B, Haddad N, Lu B, Krishnamurthy D, Yee N, Senanayake C. A Novel General Phosphine Ligand for Suzuki-Miyaura Cross-Coupling Synfacts. 2010: 1285-1285. DOI: 10.1055/S-0030-1258706 |
0.345 |
|
| 2010 |
Fandrick DR, Fandrick KR, Reeves JT, Tan Z, Tang W, Capacci AG, Rodriguez S, Song JJ, Lee H, Yee NK, Senanayake CH. Enantioselective Propargylation of Aldehydes by Copper Catalysis Synfacts. 2010: 919-919. DOI: 10.1055/S-0030-1257775 |
0.39 |
|
| 2010 |
Tang W, Capacci AG, White A, Ma S, Rodriguez S, Qu B, Savoie J, Patel ND, Wei X, Haddad N, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH. Chiral Biphosphorous Ligands for Rhodium-Catalyzed AsymmetricHydrogenation Synfacts. 2010: 675-675. DOI: 10.1055/S-0029-1219978 |
0.406 |
|
| 2010 |
Fandrick DR, Johnson CS, Fandrick KR, Reeves JT, Tan Z, Lee H, Song JJ, Yee NK, Senanayake CH. Diastereoselective Zinc-Catalyzed Propargylation of ChiralImines Synfacts. 2010: 551-551. DOI: 10.1055/S-0029-1219695 |
0.422 |
|
| 2010 |
Fandrick DR, Reeves JT, Tan Z, Lee H, Song JJ, Yee NK, Senanayake CH. Allene Synthesis and Propargylations with Stable PropargylBoronates Synfacts. 2010: 342-342. DOI: 10.1055/S-0029-1219303 |
0.425 |
|
| 2010 |
Liu J, Zhang Y, Li G, Roschangar F, Farina V, Senanayake CH, Lu BZ. A Novel One‐Pot, Two‐Step Synthesis of Polycyclic Indoles via Tandem Intramolecular Hydroamidation/Palladium‐Catalyzed Annulation Advanced Synthesis & Catalysis. 352: 2667-2671. DOI: 10.1002/Adsc.201000288 |
0.463 |
|
| 2009 |
Tang W, Capacci A, Sarvestani M, Wei X, Yee NK, Senanayake CH. A facile and practical synthesis of N-acetyl enamides. The Journal of Organic Chemistry. 74: 9528-30. PMID 19921804 DOI: 10.1021/Jo902259U |
0.402 |
|
| 2009 |
Busacca CA, Farber E, Deyoung J, Campbell S, Gonnella NC, Grinberg N, Haddad N, Lee H, Ma S, Reeves D, Shen S, Senanayake CH. Ambient temperature hydrophosphination of internal, unactivated alkynes and allenyl phosphineoxides with phosphine borane complexes. Organic Letters. 11: 5594-7. PMID 19908885 DOI: 10.1021/Ol9022547 |
0.41 |
|
| 2009 |
Wang XJ, Sidhu K, Zhang L, Campbell S, Haddad N, Reeves DC, Krishnamurthy D, Senanayake CH. Bromo-directed N-2 alkylation of NH-1,2,3-triazoles: efficient synthesis of poly-substituted 1,2,3-triazoles. Organic Letters. 11: 5490-3. PMID 19905002 DOI: 10.1021/Ol902334X |
0.51 |
|
| 2009 |
Fandrick DR, Reeves JT, Tan Z, Lee H, Song JJ, Yee NK, Senanayake CH. Regioselective allene synthesis and propargylations with propargyl diethanolamine boronates. Organic Letters. 11: 5458-61. PMID 19877630 DOI: 10.1021/Ol9022529 |
0.444 |
|
| 2009 |
Wang XJ, Zhang L, Lee H, Haddad N, Krishnamurthy D, Senanayake CH. Highly regioselective N-2 arylation of 4,5-dibromo-1,2,3-triazole: efficient synthesis of 2-aryltriazoles. Organic Letters. 11: 5026-8. PMID 19813750 DOI: 10.1021/Ol9019875 |
0.491 |
|
| 2009 |
Ma S, Shen S, Lee H, Eriksson M, Zeng X, Xu J, Fandrick K, Yee N, Senanayake C, Grinberg N. Mechanistic studies on the chiral recognition of polysaccharide-based chiral stationary phases using liquid chromatography and vibrational circular dichroism. Reversal of elution order of N-substituted alpha-methyl phenylalanine esters Journal of Chromatography A. 1216: 3784-3793. PMID 19278683 DOI: 10.1016/J.Chroma.2009.02.046 |
0.333 |
|
| 2009 |
Busacca CA, Bartholomeyzik T, Cheekoori S, Raju R, Eriksson M, Kapadia S, Saha A, Zeng X, Senanayake CH. Reduction of phosphinites, phosphinates, and related species with DIBAL-H Synlett. 287-291. DOI: 10.1055/S-0028-1087671 |
0.364 |
|
| 2009 |
Farina V, Shu C, Zeng X, Wei X, Han Z, Yee NK, Senanayake CH. Second-generation process for the hcv protease inhibitor biln 2061: A greener approach to ru-catalyzed ring-closing metathesis Organic Process Research and Development. 13: 250-254. DOI: 10.1021/Op800225F |
0.373 |
|
| 2009 |
Qu B, Haddad N, Han ZS, Rodriguez S, Lorenz JC, Grinberg N, Lee H, Busacca CA, Krishnamurthy D, Senanayake CH. Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene Tetrahedron Letters. 50: 6126-6129. DOI: 10.1016/J.Tetlet.2009.08.065 |
0.446 |
|
| 2009 |
Wu J, Sanyal S, Lu Z, Senanayake CH. Stabilizing N-tosyl-2-lithioindoles with bis(N,N′-dimethylaminoethyl) ether—a non-cryogenic procedure for lithiation of N-tosylindoles and subsequent addition to ketones Tetrahedron Letters. 50: 5667-5669. DOI: 10.1016/J.Tetlet.2009.07.120 |
0.318 |
|
| 2009 |
Song JJ, Tan Z, Reeves JT, Fandrick DR, Lee H, Yee NK, Senanayake CH. One-step construction of 2-substituted-4,6-diazaindoles from carboxylic acid derivatives Tetrahedron Letters. 50: 3952-3954. DOI: 10.1016/J.Tetlet.2009.04.080 |
0.39 |
|
| 2009 |
Reeves JT, Fandrick DR, Tan Z, Song JJ, Yee NK, Senanayake CH. Acid-promoted SN1/E1 fragmentation/dimerization of 2-cumylmalonates Tetrahedron Letters. 50: 3077-3080. DOI: 10.1016/J.Tetlet.2009.04.022 |
0.31 |
|
| 2009 |
Zhang L, Wang Xj, Wang J, Grinberg N, Krishnamurthy D, Senanayake CH. An improved method of amide synthesis using acyl chlorides Tetrahedron Letters. 50: 2964-2966. DOI: 10.1016/J.Tetlet.2009.03.220 |
0.417 |
|
| 2009 |
Reeves DC, Rodriguez S, Lee H, Haddad N, Krishnamurthy D, Senanayake CH. Palladium-catalyzed coupling of vinyl tosylates with arylsulfinate salts Tetrahedron Letters. 50: 2870-2873. DOI: 10.1016/J.Tetlet.2009.03.174 |
0.427 |
|
| 2009 |
Farina V, Zeng X, Wei X, Xu Y, Zhang L, Haddad N, Yee NK, Senanayake CH. The chemistry of Ru cyclopropylmethylidene complexes: Mechanistic studies and synthetic implications for the ring-closing metathesis reaction Catalysis Today. 140: 74-83. DOI: 10.1016/J.Cattod.2008.07.024 |
0.418 |
|
| 2009 |
Latli B, Hrapchak M, Busacca CA, Krishnamurthy D, Senanayake CH. Synthesis of [14C]- and [13C6]-labeled potent HIV non-nucleoside reverse transcriptase inhibitor Journal of Labelled Compounds and Radiopharmaceuticals. 52: 84-90. DOI: 10.1002/Jlcr.1572 |
0.401 |
|
| 2008 |
Busacca CA, Bartholomeyzik T, Cheekoori S, Grinberg N, Lee H, Ma S, Saha A, Shen S, Senanayake CH. On the racemization of chiral imidazolines. The Journal of Organic Chemistry. 73: 9756-61. PMID 19053584 DOI: 10.1021/Jo8024384 |
0.433 |
|
| 2008 |
Reeves JT, Song JJ, Tan Z, Lee H, Yee NK, Senanayake CH. Trifluoromethyl ketones from enolizable carboxylic acids via enediolate trifluoroacetylation/decarboxylation. The Journal of Organic Chemistry. 73: 9476-8. PMID 18973383 DOI: 10.1021/Jo801737C |
0.436 |
|
| 2008 |
Shu C, Zeng X, Hao MH, Wei X, Yee NK, Busacca CA, Han Z, Farina V, Senanayake CH. RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061. Organic Letters. 10: 1303-6. PMID 18293994 DOI: 10.1021/Ol800183X |
0.354 |
|
| 2008 |
Ding F, Zhang Y, Qu B, Li G, Farina V, Lu BZ, Senanayake CH. Anionic N-Fries rearrangement of N-alkyl-2-iodo anilides induced by iodine-magnesium exchange: application for synthesis of strained 1,2,3-trisubstituted indoles. Organic Letters. 10: 1067-70. PMID 18275207 DOI: 10.1021/Ol7029905 |
0.431 |
|
| 2008 |
Song JJ, Tan Z, Reeves JT, Fandrick DR, Yee NK, Senanayake CH. N-heterocyclic carbene-catalyzed silyl enol ether formation. Organic Letters. 10: 877-80. PMID 18232703 DOI: 10.1021/Ol703025B |
0.452 |
|
| 2008 |
Busacca CA, Raju R, Grinberg N, Haddad N, James-Jones P, Lee H, Lorenz JC, Saha A, Senanayake CH. Reduction of tertiary phosphine oxides with DIBAL-H. The Journal of Organic Chemistry. 73: 1524-31. PMID 18197688 DOI: 10.1021/Jo7024064 |
0.357 |
|
| 2008 |
Busacca CA, Lorenz JC, Grinberg N, Haddad N, Lee H, Li Z, Liang M, Reeves D, Saha A, Varsolona R, Senanayake CH. Asymmetric hydrogenation of unsaturated ureas with the BIPI ligands. Organic Letters. 10: 341-4. PMID 18095698 DOI: 10.1021/Ol7028542 |
0.421 |
|
| 2008 |
Song JJ, Reeves JT, Fandrick DR, Tan Z, Yee NK, Senanayake CH. Achieving synthetic efficiency through new method development Green Chemistry Letters and Reviews. 1: 141-148. DOI: 10.1080/17518250802592360 |
0.309 |
|
| 2008 |
Busacca CA, Lorenz JC, Grinberg N, Haddad N, Lee H, Li Z, Liang M, Reeves D, Saha A, Varsolona R, Senanayake CH. Highly Enantioselective Hydrogenation of Unsaturated Ureas Synfacts. 2008: 391-391. DOI: 10.1055/S-2008-1042786 |
0.311 |
|
| 2008 |
Roschangar F, Liu J, Estanove E, Dufour M, Rodríguez S, Farina V, Hickey E, Hossain A, Jones P, Lee H, Lu BZ, Varsolona R, Schröder J, Beaulieu P, Gillard J, ... Senanayake CH, et al. Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock’s indole annulation with 2-alkynylpyridines Tetrahedron Letters. 49: 363-366. DOI: 10.1016/J.Tetlet.2007.11.040 |
0.417 |
|
| 2008 |
Latli B, Hrapchak M, Krishnamurthy D, Senanayake CH. An efficient synthesis of [13C6]-3,5-dichloroaniline Journal of Labelled Compounds and Radiopharmaceuticals. 51: 283-285. DOI: 10.1002/Jlcr.1521 |
0.307 |
|
| 2008 |
Latli B, Krishnamurthy D, Senanayake C. Synthesis of tritium- and deuterium-labeled budesonide Journal of Labelled Compounds and Radiopharmaceuticals. 51: 64-67. DOI: 10.1002/Jlcr.1480 |
0.344 |
|
| 2007 |
Song JJ, Reeves JT, Gallou F, Tan Z, Yee NK, Senanayake CH. Organometallic methods for the synthesis and functionalization of azaindoles. Chemical Society Reviews. 36: 1120-32. PMID 17576479 DOI: 10.1039/B607868K |
0.409 |
|
| 2007 |
Wei X, Lorenz JC, Kapadia S, Saha A, Haddad N, Busacca CA, Senanayake CH. Tandem Pd(II)-catalyzed vinyl ether exchange-Claisen rearrangement as a facile approach to gamma,delta-unsaturated aldehydes. The Journal of Organic Chemistry. 72: 4250-3. PMID 17447813 DOI: 10.1021/Jo062548F |
0.359 |
|
| 2007 |
Reeves JT, Song JJ, Tan Z, Lee H, Yee NK, Senanayake CH. A general synthesis of substituted formylpyrroles from ketones and 4-formyloxazole. Organic Letters. 9: 1875-8. PMID 17355146 DOI: 10.1021/Ol070340Q |
0.485 |
|
| 2007 |
Song JJ, Tan Z, Reeves JT, Yee NK, Senanayake CH. N-heterocyclic carbene-catalyzed Mukaiyama aldol reactions. Organic Letters. 9: 1013-6. PMID 17295498 DOI: 10.1021/Ol0630494 |
0.436 |
|
| 2007 |
Song JJ, Tan Z, Xu J, Reeves JT, Yee NK, Ramdas R, Gallou F, Kuzmich K, Delattre L, Lee H, Feng X, Senanayake CH. Practical stereoselective synthesis of an alpha-trifluoromethyl-alpha-alkyl epoxide via a diastereoselective trifluoromethylation reaction. The Journal of Organic Chemistry. 72: 292-4. PMID 17194115 DOI: 10.1021/Jo061839L |
0.399 |
|
| 2007 |
Gallou F, Reeves JT, Tan Z, Song JJ, Yee NK, Harcken C, Liu P, Thomson D, Senanayake CH. Practical regioselective bromination of azaindoles and diazaindoles Synlett. 211-214. DOI: 10.1055/S-2007-967998 |
0.366 |
|
| 2007 |
Frutos RP, Rodríguez S, Patel N, Johnson J, Saha A, Krishnamurthy D, Senanayake CH. Efficient multikilogram synthesis of 5-bromo-2-cyclopropyl-1-methyl-1H- imidazole Organic Process Research and Development. 11: 1076-1078. DOI: 10.1021/Op700195J |
0.358 |
|
| 2007 |
Han Z, Song JJ, Yee NK, Xu Y, Tang W, Reeves JT, Tan Z, Wang XJ, Lu B, Krishnamurthy D, Senanayake CH. Development of a preparative-scale asymmetric synthesis of (R)-p-tolyl methyl sulfoxide for use in a one-pot synthesis of a drug intermediate containing a trifluoromethyl-substituted alcohol functionality Organic Process Research and Development. 11: 605-608. DOI: 10.1021/Op700010A |
0.358 |
|
| 2007 |
Song JJ, Xu J, Tan Z, Reeves JT, Grinberg N, Lee H, Kuzmich K, Feng X, Yee NK, Senanayake CH. Development of an asymmetric acetate aldol reaction with a trifluoromethyl ketone Organic Process Research and Development. 11: 534-538. DOI: 10.1021/Op060211+ |
0.437 |
|
| 2007 |
Reeves JT, Gallou F, Song JJ, Tan Z, Lee H, Yee NK, Senanayake CH. Direct conversion of primary and secondary carboxylic acids to trifluoromethyl ketones Tetrahedron Letters. 48: 189-192. DOI: 10.1016/J.Tetlet.2006.11.068 |
0.332 |
|
| 2006 |
Zeng X, Wei X, Farina V, Napolitano E, Xu Y, Zhang L, Haddad N, Yee NK, Grinberg N, Shen S, Senanayake CH. Epimerization reaction of a substituted vinylcyclopropane catalyzed by ruthenium carbenes: mechanistic analysis. The Journal of Organic Chemistry. 71: 8864-75. PMID 17081017 DOI: 10.1021/Jo061587O |
0.445 |
|
| 2006 |
Liu J, Shen M, Zhang Y, Li G, Khodabocus A, Rodriguez S, Qu B, Farina V, Senanayake CH, Lu BZ. A new entry to polycyclic indole skeletons via palladium-catalyzed intramolecular heteroannulation. Organic Letters. 8: 3573-5. PMID 16869663 DOI: 10.1021/Ol061440J |
0.447 |
|
| 2006 |
Lu BZ, Zhao W, Wei HX, Dufour M, Farina V, Senanayake CH. A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions. Organic Letters. 8: 3271-4. PMID 16836383 DOI: 10.1021/Ol061136Q |
0.444 |
|
| 2006 |
Farina V, Reeves JT, Senanayake CH, Song JJ. Asymmetric synthesis of active pharmaceutical ingredients. Chemical Reviews. 106: 2734-93. PMID 16836298 DOI: 10.1021/Cr040700C |
0.392 |
|
| 2006 |
Wang XJ, Xu Y, Zhang L, Krishnamurthy D, Senanayake CH. Mild iodine-magnesium exchange of iodoaromatics bearing a pyrimidine ring with isopropylmagnesium chloride. Organic Letters. 8: 3141-4. PMID 16805572 DOI: 10.1021/Ol061156S |
0.399 |
|
| 2006 |
Song JJ, Gallou F, Reeves JT, Tan Z, Yee NK, Senanayake CH. Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds. The Journal of Organic Chemistry. 71: 1273-6. PMID 16438554 DOI: 10.1021/Jo052206U |
0.375 |
|
| 2006 |
Wang XJ, Sun X, Zhang L, Xu Y, Krishnamurthy D, Senanayake CH. Noncryogenic I/Br-Mg exchange of aromatic halides bearing sensitive functional groups using i-PrMgCl-bis[2-(N,N-dimethylamino)ethyl] ether complexes. Organic Letters. 8: 305-7. PMID 16408901 DOI: 10.1021/Ol052704P |
0.383 |
|
| 2006 |
Lu B, Zhao W, Wei H-, Dufour M, Farina V, Senanayake C. One-Pot Synthesis of 2,3-Disubstituted Indoles Synfacts. 2006: 1109-1109. DOI: 10.1055/S-2006-949421 |
0.45 |
|
| 2006 |
Gallou F, Saim S, Koenig KJ, Bochniak D, Horhota ST, Yee NK, Senanayake CH. A practical method for the removal of ruthenium byproducts by supercritical fluid extraction Organic Process Research and Development. 10: 937-940. DOI: 10.1021/Op0601114 |
0.343 |
|
| 2006 |
Han Z, Krishnamurthy D, Senanayake CH. A new and direct asymmetric synthesis of a hindered chiral amine via a novel sulfinate ketimine derived from N-tosyl-1,2,3-oxathiazolidme-2-oxide: Practical asymmetric synthesis of (R)-sibutramine Organic Process Research and Development. 10: 327-333. DOI: 10.1021/Op050182N |
0.459 |
|
| 2005 |
Wang XJ, Zhang L, Sun X, Xu Y, Krishnamurthy D, Senanayake CH. Addition of grignard reagents to aryl acid chlorides: an efficient synthesis of aryl ketones. Organic Letters. 7: 5593-5. PMID 16320999 DOI: 10.1021/Ol052150Q |
0.452 |
|
| 2005 |
Busacca CA, Lorenz JC, Grinberg N, Haddad N, Hrapchak M, Latli B, Lee H, Sabila P, Saha A, Sarvestani M, Shen S, Varsolona R, Wei X, Senanayake CH. A superior method for the reduction of secondary phosphine oxides. Organic Letters. 7: 4277-80. PMID 16146406 DOI: 10.1021/Ol0517832 |
0.308 |
|
| 2005 |
Busacca CA, Campbell S, Saha A, Lorenz JC, Grozinger K, Jones PJ, Grinberg N, Shen S, Lee H, Qiu F, Granger A, Yuabova Z, Norwood D, Senanayake CH. Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir drug product. Magnetic Resonance in Chemistry : Mrc. 43: 1032-9. PMID 16142832 DOI: 10.1002/Mrc.1672 |
0.335 |
|
| 2005 |
Gallou I, Eriksson M, Zeng X, Senanayake C, Farina V. Practical synthesis of unsymmetrical ureas from isopropenyl carbamates. The Journal of Organic Chemistry. 70: 6960-3. PMID 16095326 DOI: 10.1021/Jo0507643 |
0.463 |
|
| 2005 |
Song JJ, Tan Z, Gallou F, Xu J, Yee NK, Senanayake CH. A novel one-step synthesis of 2-substituted 6-azaindoles from 3-amino-4-picoline and carboxylic esters. The Journal of Organic Chemistry. 70: 6512-4. PMID 16050720 DOI: 10.1021/Jo0506480 |
0.439 |
|
| 2005 |
Lu BZ, Senanayake C, Li N, Han Z, Bakale RP, Wald SA. Control of diastereoselectivity by solvent effects in the addition of Grignard reagents to enantiopure t-butylsulfinimine: syntheses of the stereoisomers of the hydroxyl derivatives of sibutramine. Organic Letters. 7: 2599-602. PMID 15957900 DOI: 10.1021/Ol0507017 |
0.365 |
|
| 2005 |
Song JJ, Tan Z, Reeves JT, Gallou F, Yee NK, Senanayake CH. N-heterocyclic carbene catalyzed trifluoromethylation of carbonyl compounds. Organic Letters. 7: 2193-6. PMID 15901167 DOI: 10.1021/Ol050568I |
0.449 |
|
| 2005 |
Lu BZ, Jin F, Zhang Y, Wu X, Wald SA, Senanayake CH. New general sulfinylating process for asymmetric synthesis of enantiopure sulfinates and sulfoxides. Organic Letters. 7: 1465-8. PMID 15816728 DOI: 10.1021/Ol0501020 |
0.443 |
|
| 2005 |
Gallou F, Reeves JT, Tan Z, Song JJ, Yee NK, Campbell S, Jones PJ, Senanayake CH. Regioselective halogenation of 6-azaindoles: Efficient synthesis of 3-halo-2,3-disubstituted-6-azaindole derivatives Synlett. 2400-2402. DOI: 10.1055/S-2005-872680 |
0.421 |
|
| 2005 |
Frutos RP, Eriksson M, Wang XJ, Byrne D, Varsolona R, Johnson MD, Nummy L, Krishnamurthy D, Senanayake CH. Development of a scalable process for 1-(3,5-dichlorophenyl)-5-iodo-3- methyl-(4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A key intermediate for the synthesis of LFA-1 inhibitors Organic Process Research and Development. 9: 137-140. DOI: 10.1021/Op049813O |
0.364 |
|
| 2005 |
Frutos RP, Gallou I, Reeves D, Xu Y, Krishnamurthy D, Senanayake CH. Expedient synthesis of substituted imidazoles from nitriles Tetrahedron Letters. 46: 8369-8372. DOI: 10.1016/J.Tetlet.2005.09.153 |
0.455 |
|
| 2005 |
Wang XJ, Zhang L, Xu Y, Krishnamurthy D, Varsolona R, Nummy L, Shen S, Frutos RP, Byrne D, Chung JC, Farina V, Senanayake CH. A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins Tetrahedron Letters. 46: 273-276. DOI: 10.1016/J.Tetlet.2004.11.065 |
0.335 |
|
| 2005 |
Han Z, Krishnamurthy D, Grover P, Fang QK, Su X, Wilkinson HS, Lu ZH, Magiera D, Senanayake CH. Practical and highly stereoselective technology for preparation of enantiopure sulfoxides and sulfinamides utilizing activated and functionally differentiated N-sulfonyl-1,2,3-oxathiazolidine-2-oxide derivatives Tetrahedron. 61: 6386-6408. DOI: 10.1016/J.Tet.2005.03.122 |
0.418 |
|
| 2004 |
Song JJ, Yee NK, Tan Z, Xu J, Kapadia SR, Senanayake CH. Synthesis of 5-bromopyridyl-2-magnesium chloride and its application in the synthesis of functionalized pyridines. Organic Letters. 6: 4905-7. PMID 15606096 DOI: 10.1021/Ol0400589 |
0.478 |
|
| 2004 |
Shen M, Li G, Lu BZ, Hossain A, Roschangar F, Farina V, Senanayake CH. The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: a new approach to 2,3-disubstituted indoles. Organic Letters. 6: 4129-32. PMID 15496116 DOI: 10.1021/Ol048114T |
0.467 |
|
| 2004 |
Wang X, Xu Y, Zhang L, Krishnamurthy D, Nummy L, Farina V, Senanayake CH. A practical synthesis of highly functionalized fused 1,6-dihydroimidazo-[1,2-a]imidazole-2,5-diones, key intermediates for LFA-1 inhibitors Synlett. 2005: 2800-2802. DOI: 10.1055/S-2004-836064 |
0.388 |
|
| 2004 |
Gallou F, Yee N, Qiu F, Senanayake C, Linz G, Schnaubelt J, Soyka R. A practical synthesis of 2-aryl-indole-6-carboxylic acids Synlett. 2004: 883-885. DOI: 10.1055/S-2004-820015 |
0.441 |
|
| 2004 |
Wang XJ, Zhang L, Xu Y, Krishnamurthy D, Senanayake CH. A practical synthesis of 2-(N-substituted)-aminobenzimidazoles utilizing CuCl-promoted intramolecular cyclization of N-(2-aminoaryl)thioureas Tetrahedron Letters. 45: 7167-7170. DOI: 10.1016/J.Tetlet.2004.07.042 |
0.387 |
|
| 2003 |
Han Z, Krishnamurthy D, Grover P, Fang QK, Pflum DA, Senanayake CH. Effective tuning of the arene and alkanesulfinamides for highly enantioselective synthesis of (S)-4-chlorophenylphenylmethylamine, a key intermediate for antihistamic (S)-cetirizine Tetrahedron Letters. 44: 4195-4197. DOI: 10.1016/S0040-4039(03)00903-1 |
0.428 |
|
| 2003 |
Han Z, Krishnamurthy D, Fang QK, Wald SA, Senanayake CH. New resolution approach for large-scale preparation of enantiopure didesmethylsibutramine (DDMS) Tetrahedron Asymmetry. 14: 3553-3556. DOI: 10.1016/J.Tetasy.2003.08.042 |
0.363 |
|
| 2003 |
Su X, Bhongle NN, Pflum D, Butler H, Wald SA, Bakale RP, Senanayake CH. A large-scale asymmetric synthesis of (S)-cyclohexylphenyl glycolic acid Tetrahedron-Asymmetry. 14: 3593-3600. DOI: 10.1016/J.Tetasy.2003.08.036 |
0.381 |
|
| 2003 |
Tanoury GJ, Hett R, Wilkinson HS, Wald SA, Senanayake CH. Total synthesis of (2R,4S,2′S,3′R)-hydroxyitraconazole: implementations of a recycle protocol and a mild and safe phase-transfer reagent for preparation of the key chiral units Tetrahedron-Asymmetry. 14: 3487-3493. DOI: 10.1016/J.Tetasy.2003.01.001 |
0.33 |
|
| 2003 |
Larrow JF, Roberts E, Verhoeven TR, Ryan KM, Senanayake CH, Reider PJ, Jacobsen EN. (1S,2R)‐1‐Aminoindan‐2‐ol Organic Syntheses. 76: 46-46. DOI: 10.1002/0471264180.Os076.06 |
0.415 |
|
| 2002 |
Han Z, Krishnamurthy D, Pflum D, Grover P, Wald SA, Senanayake CH. First application of tunable alkyl or aryl sulfinamides to the stereoselective synthesis of a chiral amine: asymmetric synthesis of (R)-didesmethylsibutramine ((R)-DDMS) using (R)-triethylmethylsulfinamide ((R)-TESA). Organic Letters. 4: 4025-8. PMID 12423077 DOI: 10.1021/Ol026699Q |
0.342 |
|
| 2002 |
Han Z, Krishnamurthy D, Grover P, Fang QK, Senanayake CH. Properly designed modular asymmetric synthesis for enantiopure sulfinamide auxiliaries from N-sulfonyl-1,2,3-oxathiazolidine-2-oxide agents. Journal of the American Chemical Society. 124: 7880-1. PMID 12095314 DOI: 10.1021/Ja0200692 |
0.404 |
|
| 2002 |
Wilkinson HS, Tanoury GJ, Wald aSA, Senanayake CH. Diethylanilineborane: A Practical, Safe, and Consistent-Quality Borane Source for the Large-Scale Enantioselective Reduction of a Ketone Intermediate in the Synthesis of (R,R)-Formoterol Organic Process Research & Development. 6: 146-148. DOI: 10.1021/Op015504B |
0.346 |
|
| 2002 |
Han Z, Krishnamurthy D, Pflum D, Fang QK, Butler H, Cameron TS, Wald SA, Senanayake CH. First practical synthesis of enantiomerically pure (R)- and (S)-desmethylsibutramine (DMS) and unambiguous determination of their absolute configuration by single-crystal X-ray analysis Tetrahedron Asymmetry. 13: 107-109. DOI: 10.1016/S0957-4166(02)00086-1 |
0.312 |
|
| 2002 |
Lu Z, Bhongle N, Su X, Ribe S, Senanayake CH. Novel diacid accelerated borane reducing agent for imines Tetrahedron Letters. 43: 8617-8620. DOI: 10.1016/S0040-4039(02)01905-6 |
0.329 |
|
| 2002 |
Krishnamurthy D, Han Z, Wald SA, Senanayake CH. First asymmetric synthesis of (R)-desmethylsibutramine Tetrahedron Letters. 43: 2331-2333. DOI: 10.1016/S0040-4039(02)00297-6 |
0.363 |
|
| 2002 |
Pflum DA, Krishnamurthy D, Han Z, Wald SA, Senanayake CH. Asymmetric synthesis of cetirizine dihydrochloride Tetrahedron Letters. 43: 923-926. DOI: 10.1016/S0040-4039(01)02294-8 |
0.338 |
|
| 2001 |
Wilkinson HS, Grover PT, Vandenbossche CP, Bakale RP, Bhongle NN, Wald SA, Senanayake CH. A new lithium alkoxide accelerated diastereoselective cyanation of ketones. Organic Letters. 3: 553-6. PMID 11178823 DOI: 10.1021/Ol0069608 |
0.42 |
|
| 2001 |
Fang QK, Grover P, Han Z, McConville FX, Rossi RF, Olsson DJ, Kessler DW, Wald SA, Senanayake CH. Practical chemical and enzymatic technologies for (S)-1,4-benzodioxan-2-carboxypiperizine intermediate in the synthesis of (S)-doxazosin mesylate Tetrahedron-Asymmetry. 12: 2169-2174. DOI: 10.1016/S0957-4166(01)00368-8 |
0.366 |
|
| 2001 |
Hilborn JW, Lu Z, Jurgens AR, Fang Q, Byers P, Wald SA, Senanayake CH. A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine Tetrahedron Letters. 42: 8919-8921. DOI: 10.1016/S0040-4039(01)01877-9 |
0.391 |
|
| 2001 |
Wilkinson HS, Tanoury GJ, Wald SA, Senanayake CH. Chemoselective reductions of nitroarenes: bromoethanol-assisted phthalocyanatoiron/NaBH4 reductions Tetrahedron Letters. 42: 167-170. DOI: 10.1016/S0040-4039(00)01920-1 |
0.345 |
|
| 2000 |
Grover PT, Bhongle NN, Wald SA, Senanayake CH. Chiral mandelic acid template provides a highly practical solution for (S)-oxybutynin synthesis. The Journal of Organic Chemistry. 65: 6283-7. PMID 10987980 DOI: 10.1021/Jo005562F |
0.373 |
|
| 2000 |
Hong Y, Bakale RP, Fang QK, Xiang T, Han Z, McConville FX, Senanayake CH, Wald SA. Synthesis of enantiomerically pure desmethylzopiclone and determination of its absolute configuration Tetrahedron-Asymmetry. 11: 4623-4627. DOI: 10.1016/S0957-4166(00)00455-9 |
0.393 |
|
| 2000 |
Fang QK, Han Z, Grover P, Kessler D, Senanayake CH, Wald SA. Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an α-ketotriflate Tetrahedron-Asymmetry. 11: 3659-3663. DOI: 10.1016/S0957-4166(00)00349-9 |
0.366 |
|
| 1999 |
Senanayake CH, Hong Y, Xiang T, Wilkinson HS, Bakale RP, Jurgens AR, Pippert MF, Butler HT, Wald SA. Properly tuned first fluoride-catalyzed TGME-mediated amination process for chloroimidazoles: inexpensive technology for antihistaminic norastemizole Tetrahedron Letters. 40: 6875-6879. DOI: 10.1016/S0040-4039(99)01350-7 |
0.372 |
|
| 1999 |
Senanayake CH, Fang K, Grover P, Bakale RP, Vandenbossche CP, Wald SA. Rigid aminoalcohol backbone as a highly defined chiral template for the preparation of optically active tertiary α-hydroxyl acids Tetrahedron Letters. 40: 819-822. DOI: 10.1016/S0040-4039(98)02587-8 |
0.373 |
|
| 1998 |
Ghosh AK, Fidanze S, Senanayake CH. -1-Aminoindan-2-ol in Asymmetric Syntheses. Synthesis. 1998: 937-961. PMID 30393403 DOI: 10.1055/S-1998-2092 |
0.389 |
|
| 1998 |
Hett R, Fang QK, Gao Y, Wald SA, Senanayake CH. Large-Scale Synthesis of Enantio- and Diastereomerically Pure (R,R)-Formoterol† Organic Process Research & Development. 2: 96-99. DOI: 10.1021/Op970116O |
0.309 |
|
| 1998 |
Tanoury GJ, Senanayake CH, Hett R, Kuhn AM, Kessler DW, Wald SA. Pd-catalyzed aminations of aryl triazolones: Effective synthesis of hydroxyitraconazole enantiomers Tetrahedron Letters. 39: 6845-6848. DOI: 10.1016/S0040-4039(98)01493-2 |
0.507 |
|
| 1998 |
Hong Y, Senanayake CH, Xiang T, Vandenbossche CP, Tanoury GJ, Bakale RP, Wald SA. Remarkably selective palladium-catalyzed amination process: Rapid assembly of multiamino based structures Tetrahedron Letters. 39: 3121-3124. DOI: 10.1016/S0040-4039(98)00517-6 |
0.405 |
|
| 1998 |
Fang QK, Senanayake CH, Wilkinson HS, Wald SA, Li H. An efficient and facile synthesis of racemic and optically active fexofenadine Tetrahedron Letters. 39: 2701-2704. DOI: 10.1016/S0040-4039(98)00410-9 |
0.351 |
|
| 1998 |
Hett R, Senanayake CH, Wald SA. Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R,)-formoterol Tetrahedron Letters. 39: 1705-1708. DOI: 10.1016/S0040-4039(98)00137-3 |
0.355 |
|
| 1997 |
Hughes DL, Smith GB, Liu J, Dezeny GC, Senanayake CH, Larsen RD, Verhoeven TR, Reider PJ. Mechanistic Study of the Jacobsen Asymmetric Epoxidation of Indene. The Journal of Organic Chemistry. 62: 2222-2229. PMID 11671532 DOI: 10.1021/Jo961735I |
0.355 |
|
| 1997 |
Cvetovich RJ, Senanayake CH, Amato JS, DiMichele LM, Bill TJ, Larsen RD, Shuman RF, Verhoeven TR, Grabowski EJJ. Practical Syntheses of 13-O-[(2-Methoxyethoxy)methyl]-22,23-dihydroavermectin B1 Aglycon [Dimedectin Isopropanol, MK-324] and 13-epi-O-(Methoxymethyl)-22,23-Dihydroavermectin B1 Aglycon [L-694,554], Flea Active Ivermectin Analogues Journal of Organic Chemistry. 62: 3989-3993. DOI: 10.1021/Jo970187L |
0.303 |
|
| 1997 |
Tanoury GJ, Senanayake CH, Hett R, Hong Y, Wald SA. Efficient stereoselective synthesis of cis,syn-hydroxyitraconazole isomers Tetrahedron Letters. 38: 7839-7842. DOI: 10.1016/S0040-4039(97)10129-0 |
0.393 |
|
| 1997 |
Hong Y, Tanoury GJ, Wilkinson HS, Bakale RP, Wald SA, Senanayake CH. Palladium catalyzed amination of 2-chloro-1,3-azole derivatives: Mild entry to potent H1- antihistaminic norastemizole Tetrahedron Letters. 38: 5607-5610. DOI: 10.1016/S0040-4039(97)01273-2 |
0.436 |
|
| 1996 |
Davies IW, Gerena L, Castonguay L, Senanayake CH, Larsen RD, Verhoeven TR, Reider PJ. The Influence Of Ligand Bite Angle On The Enantioselectivity Of Copper(Ii)-Catalysed Diels-Alder Reactions Chemical Communications. 1753-1754. DOI: 10.1039/Cc9960001753 |
0.403 |
|
| 1996 |
Senanayake CH, Larsen RD, DiMichele LM, Liu J, Toma PH, Ball RG, Verhoeven TR, Reider PJ. Asymmetric synthesis of conformationally constrained cis-1-amino-1-phenylcyclohexan-2-ol Tetrahedron Asymmetry. 7: 1501-1506. DOI: 10.1016/0957-4166(96)00169-3 |
0.403 |
|
| 1996 |
Senanayake CH, Smith GB, Ryan KM, Fredenburgh LE, Liu J, Roberts FE, Hughes DL, Larsen RD, Verhoeven TR, Reider PJ. The role of 4-(3-phenylpropyl)pyridine N-oxide (P3NO) in the manganese-salen-catalyzed asymmetric epoxidation of indene Tetrahedron Letters. 37: 3271-3274. DOI: 10.1016/0040-4039(96)00565-5 |
0.331 |
|
| 1996 |
Davies IW, Senanayake CH, Larsen RD, Verhoeven TR, Reider PJ. Application of indane-derived C2-symmetric bis(oxazolines) in two-point binding asymmetric Diels-Alder reactions Tetrahedron Letters. 37: 1725-1726. DOI: 10.1016/0040-4039(96)00119-0 |
0.424 |
|
| 1996 |
Davies IW, Senanayake CH, Larsen RD, Verhoeven TR, Reider PJ. Application of a Ritter-type reaction to the synthesis of chiral indane-derived C2-symmetric bis(oxazolines) Tetrahedron Letters. 37: 813-814. DOI: 10.1016/0040-4039(95)02328-3 |
0.456 |
|
| 1995 |
Davies IW, Senanayake CH, Castonguay L, Larsen RD, Verhoeven TR, Reider PJ. Highly diastereoselective diels-alder reaction mediated by a chiral auxiliary derived from amino indanol: The role of conformation on diastereoselectivity Tetrahedron Letters. 36: 7619-7622. DOI: 10.1016/0040-4039(95)01584-5 |
0.453 |
|
| 1995 |
Senanayake CH, DiMichele LM, Liu J, Fredenburgh LE, Ryan KM, Edward Roberts F, Larsen RD, Verhoeven TR, Reider PJ. Regio- and stereocontrolled syntheses of cyclic chiral cis-amino alcohols from 1,2-diols or epoxides Tetrahedron Letters. 36: 7615-7618. DOI: 10.1016/0040-4039(95)01583-4 |
0.321 |
|
| 1995 |
Senanayake CH, Roberts FE, DiMichele LM, Ryan KM, Liu J, Fredenburgh LE, Foster BS, Douglas AW, Larsen RD, Verhoeven TR, Reider PJ. The behavior of indene oxide in the ritter reaction: A simple route to cis-aminoindanol Tetrahedron Letters. 36: 3993-3996. DOI: 10.1016/0040-4039(95)00696-A |
0.362 |
|
| 1994 |
Senanayake CH, Larsen RD, Bill TJ, Liu J, Corley EG, Reider PJ. Enantioselective synthesis of 1,3-dioxygen-substituted chiral building blocks Synlett. 1994: 199-200. DOI: 10.1055/S-1994-22793 |
0.44 |
|
| 1994 |
Rigby JH, McGuire T, Senanayake C, Khemani K. Synthetic studies on the ophiobolane sesterterpenes: Construction of an optically pure, advanced tricyclic intermediate for the synthesis of ceroplasteric acid Journal of the Chemical Society, Perkin Transactions 1. 3449-3457. DOI: 10.1039/P19940003449 |
0.61 |
|
| 1994 |
Chen Cy, Senanayake CH, Bill TJ, Larsen RD, Verhoeven TR, Reider PJ. Improved Fischer Indole Reaction for the Preparation of N,N-Dimethyltryptamines: Synthesis of L-695,894, a Potent 5-HT1D Receptor Agonist Journal of Organic Chemistry. 59: 3738-3741. DOI: 10.1021/Jo00092A046 |
0.353 |
|
| 1994 |
Senanayake CH, Fredenburgh LE, Reamer RA, Liu J, Larsen RD, Verhoeven TR, Reider PJ. Magnesium-assisted imidazole formation from unreactive ureas Tetrahedron Letters. 35: 5775-5778. DOI: 10.1016/S0040-4039(00)78181-0 |
0.427 |
|
| 1993 |
Senanayake CH, Bill TJ, DiMichele LM, Chen CY, Larsen RD, Verhoeven TR, Reider PJ. Stereocontrolled functionalization of the diene system of compactin Tetrahedron Letters. 34: 6021-6024. DOI: 10.1016/S0040-4039(00)61717-3 |
0.36 |
|
| 1993 |
Senanayake CH, Singh SB, Bill TJ, DiMichele LM, Liu J, Larsen RD, Verhoeven TR. Inversion of the sterically constrained C13-hydroxyl of 22,23-dihydroavermectin B1 aglycone Tetrahedron Letters. 34: 2425-2428. DOI: 10.1016/S0040-4039(00)60432-X |
0.305 |
|
| 1992 |
Johnson CR, Adams JP, Bis SJ, Randall R, Golebiowski A, Medich JR, Penning TD, Senanayake CH, Steensma DH, Van Zandt M. Applications of enzymes in the synthesis of bioactive polyols Pure and Applied Chemistry. 64: 1115-1120. DOI: 10.1351/Pac199264081115 |
0.335 |
|
| 1992 |
Senanayake CH, Bill TJ, Larsen RD, Leazer J, Reider PJ. Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids Tetrahedron Letters. 33: 5901-5904. DOI: 10.1016/S0040-4039(00)61084-5 |
0.385 |
|
| 1989 |
Johnson CR, Senanayake CH. Polyhydroxylated seven-membered chiral building blocks. Asymmetric synthesis of compactin analogs Journal of Organic Chemistry. 54: 735-736. DOI: 10.1021/Jo00265A002 |
0.414 |
|
| 1988 |
Rigby JH, Senanayake CH, Rege S. Lithium enolate additions to the tropone nucleus Journal of Organic Chemistry. 53: 4596-4598. DOI: 10.1021/Jo00254A040 |
0.54 |
|
| 1988 |
Rigby JH, Senanayake C. An efficient electrophile-initiated homoconjugate addition of acetate to cyclopropyl ketones Journal of Organic Chemistry. 53: 440-443. DOI: 10.1021/Jo00237A045 |
0.628 |
|
| 1987 |
Rigby JH, Senanayake C. A synthetic entry into the ophiobolane ring system Journal of Organic Chemistry. 52: 4634-4635. DOI: 10.1021/Jo00229A046 |
0.544 |
|
| 1987 |
Rigby JH, Senanayake C. Total synthesis of (±)-grosshemin Journal of the American Chemical Society. 109: 3147-3149. DOI: 10.1021/Ja00244A049 |
0.543 |
|
| 1986 |
Rigby JH, Wilaon JZ, Senanayake C. Intramolecular Lewis acid catalyzed heterocycloaddition reactions. Cyclization of ketone heterodienophiles in the dihydrotropone series Tetrahedron Letters. 27: 3329-3332. DOI: 10.1016/S0040-4039(00)84787-5 |
0.658 |
|
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