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Alex Evers - Publications

Affiliations: 
Anesthesiology Washington University School of Medicine, St. Louis, MO, United States 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Germann AL, Xu Y, Covey DF, Evers AS, Akk G. Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay. Acs Chemical Neuroscience. PMID 38386612 DOI: 10.1021/acschemneuro.3c00836  0.51
2021 Wang L, Covey DF, Akk G, Evers AS. Neurosteroid modulation of GABAA receptor function by independent action at multiple specific binding sites. Current Neuropharmacology. PMID 34856904 DOI: 10.2174/1570159X19666211202150041  0.564
2021 Germann AL, Pierce SR, Tateiwa H, Sugasawa Y, Reichert DE, Evers AS, Steinbach JH, Akk G. Intrasubunit and intersubunit steroid binding sites independently and additively mediate α1β2γ2L GABA receptor potentiation by the endogenous neurosteroid allopregnanolone. Molecular Pharmacology. PMID 33958479 DOI: 10.1124/molpharm.121.000268  0.497
2020 Pierce SR, Germann AL, Evers AS, Steinbach JH, Akk G. Reduced activation of the synaptic-type GABA receptor following prolonged exposure to low concentrations of agonists: relationship between tonic activity and desensitization. Molecular Pharmacology. PMID 32978327 DOI: 10.1124/molpharm.120.000088  0.42
2020 Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS. Site-specific effects of neurosteroids on GABA receptor activation and desensitization. Elife. 9. PMID 32955433 DOI: 10.7554/Elife.55331  0.682
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA Receptor: Relating Occupancy to State Functions. Molecular Pharmacology. 98: 303-313. PMID 32873746 DOI: 10.1124/Molpharm.120.000066  0.565
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of muscimol binding and gating by allosteric modulators of the GABA receptor: relating occupancy to state functions. Molecular Pharmacology. PMID 32723768 DOI: 10.1124/molpharm.120.000066  0.565
2020 Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G. Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites. Molecular Pharmacology. PMID 32675382 DOI: 10.1124/Mol.120.119842  0.576
2019 Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31176038 DOI: 10.1016/J.Bbalip.2019.06.004  0.394
2019 Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. The Molecular Determinants of Neurosteroid Binding in the GABA(A) Receptor. The Journal of Steroid Biochemistry and Molecular Biology. 105383. PMID 31150831 DOI: 10.1016/J.Jsbmb.2019.105383  0.522
2019 Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. Multiple functional neurosteroid binding sites on GABAA receptors. Plos Biology. 17: e3000157. PMID 30845142 DOI: 10.1371/Journal.Pbio.3000157  0.606
2018 Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Kathiresan K, Mydock-McGrane L, Covey DF, Evers AS. Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30471426 DOI: 10.1016/J.Bbalip.2018.11.005  0.333
2018 Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G. Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam. Scientific Reports. 8: 10341. PMID 29985445 DOI: 10.1038/S41598-018-28754-7  0.42
2018 Germann A, Shin D, Kuhrau C, Johnson A, Evers AS, Akk G. High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors. Molecular Pharmacology. PMID 29439087 DOI: 10.1124/Mol.117.111435  0.345
2018 Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC. The Journal of Biological Chemistry. PMID 29301936 DOI: 10.1074/Jbc.Ra117.000359  0.425
2018 Chen Z, Bracamontes J, Cheng WW, Budelier M, Kathiresan K, Qian M, Covey DF, Evers AS. Identification of Neurosteroid Binding Sites on GABAA Receptors using Photolabeling with Mass Spectrometry Biophysical Journal. 114: 25a. DOI: 10.1016/J.Bpj.2017.11.183  0.461
2017 Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. The Journal of Biological Chemistry. PMID 28396346 DOI: 10.1074/Jbc.M116.773069  0.338
2015 Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G. Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular Pharmacology. 88: 736-45. PMID 26206487 DOI: 10.1124/Mol.115.100347  0.533
2014 Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G. The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. British Journal of Pharmacology. 171: 5446-57. PMID 25117207 DOI: 10.1111/Bph.12861  0.544
2014 Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology. 231: 3479-91. PMID 24756762 DOI: 10.1007/S00213-014-3568-4  0.497
2014 Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of Medicinal Chemistry. 57: 171-90. PMID 24328079 DOI: 10.1021/Jm401577C  0.345
2013 Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nature Chemical Biology. 9: 715-20. PMID 24056400 DOI: 10.1038/Nchembio.1340  0.496
2012 Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/Mol.112.078410  0.529
2012 Chen ZW, Chen LH, Akentieva N, Lichti CF, Darbandi R, Hastings R, Covey DF, Reichert DE, Townsend RR, Evers AS. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis. 33: 666-74. PMID 22451060 DOI: 10.1002/Elps.201100434  0.374
2012 Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. Journal of Medicinal Chemistry. 55: 1334-45. PMID 22191644 DOI: 10.1021/Jm2014925  0.591
2012 Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British Journal of Pharmacology. 165: 2228-43. PMID 21950777 DOI: 10.1111/J.1476-5381.2011.01690.X  0.425
2011 Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. Journal of Medicinal Chemistry. 54: 3926-34. PMID 21504158 DOI: 10.1021/Jm2002487  0.359
2010 Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current Neuropharmacology. 8: 18-25. PMID 20808543 DOI: 10.2174/157015910790909458  0.484
2010 Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF. A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of Pharmacology and Experimental Therapeutics. 333: 404-13. PMID 20124410 DOI: 10.1124/Jpet.109.164079  0.516
2009 Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Molecular Pharmacology. 76: 754-65. PMID 19596835 DOI: 10.1124/Mol.109.057687  0.492
2009 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology. 34: S59-66. PMID 19541427 DOI: 10.1016/J.Psyneuen.2009.05.020  0.537
2008 Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of Medicinal Chemistry. 51: 1309-18. PMID 18275132 DOI: 10.1021/Jm701128R  0.437
2008 Li P, Reichert DE, Rodríguez AD, Manion BD, Evers AS, Eterović VA, Steinbach JH, Akk G. Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. British Journal of Pharmacology. 153: 598-608. PMID 18037909 DOI: 10.1038/Sj.Bjp.0707597  0.457
2008 Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European Journal of Medicinal Chemistry. 43: 107-13. PMID 17434649 DOI: 10.1016/J.Ejmech.2007.02.017  0.44
2007 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & Therapeutics. 116: 35-57. PMID 17524487 DOI: 10.1016/J.Pharmthera.2007.03.004  0.47
2005 Zeng CM, Manion BD, Benz A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 48: 3051-9. PMID 15828844 DOI: 10.1021/Jm049027+  0.301
2004 Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular Pharmacology. 65: 1191-7. PMID 15102947 DOI: 10.1124/Mol.65.5.1191  0.405
2004 Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, He Y, Sheiko TV, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 308: 502-11. PMID 14593090 DOI: 10.1124/Jpet.103.058123  0.467
2003 Darbandi-Tonkabon R, Hastings WR, Zeng CM, Akk G, Manion BD, Bracamontes JR, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of Biological Chemistry. 278: 13196-206. PMID 12560326 DOI: 10.1074/Jbc.M213168200  0.381
2001 Covey DF, Evers AS, Mennerick S, Zorumski CF, Purdy RH. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain Research. Brain Research Reviews. 37: 91-7. PMID 11744077 DOI: 10.1016/S0165-0173(01)00126-6  0.547
1997 Hu Y, Wittmer LL, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Neurosteroid analogues. Part 5.1 Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles Journal of the Chemical Society-Perkin Transactions 1. 3665-3672. DOI: 10.1039/A703212I  0.419
1997 Hu Y, Wittmer LL, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Neurosteroid analogues. Part 5. Enantiomers of neuroactive steroids and benz[e]indenes: Total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles Journal of the Chemical Society - Perkin Transactions 1. 3665-3671.  0.419
1993 Dubois BW, Cherian SF, Evers AS. Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study. Proceedings of the National Academy of Sciences of the United States of America. 90: 6478-82. PMID 8341659 DOI: 10.1073/PNAS.90.14.6478  0.402
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