Hyuk Jin Cha, Ph.D - Publications

Affiliations: 
Pharmacy Seoul National University, Seoul, South Korea 
Area:
Stem Cells, Cell cycle, DNA damage, Signaling, Pluripotency, gene editing

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kim J, Kwon EJ, Kim YJ, Kim D, Shin YZ, Gil D, Kim JH, Shin HD, Kim LH, Lee MO, Go YH, Cha HJ. Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity. Cellular and Molecular Life Sciences : Cmls. 81: 38. PMID 38214772 DOI: 10.1007/s00018-023-05060-8  0.306
2021 Kwon OS, Lee H, Kong HJ, Kwon EJ, Park JE, Lee W, Kang S, Kim M, Kim W, Cha HJ. Correction to: Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer. Oncogene. PMID 33574481 DOI: 10.1038/s41388-021-01642-7  0.699
2020 Kong HJ, Kwon EJ, Kwon OS, Lee H, Choi JY, Kim YJ, Kim W, Cha HJ. Crosstalk between YAP and TGFβ regulates SERPINE1 expression in mesenchymal lung cancer cells. International Journal of Oncology. PMID 33367928 DOI: 10.3892/ijo.2020.5153  0.758
2020 Choi JY, Lee H, Kwon EJ, Kong HJ, Kwon OS, Cha HJ. TGFβ promotes YAP-dependent AXL induction in mesenchymal-type lung cancer cells. Molecular Oncology. PMID 33207077 DOI: 10.1002/1878-0261.12857  0.757
2020 Kwon OS, Kwon EJ, Kong HJ, Choi JY, Kim YJ, Lee EW, Kim W, Lee H, Cha HJ. Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis. Redox Biology. 37: 101719. PMID 32979793 DOI: 10.1016/j.redox.2020.101719  0.743
2020 Kim KT, Park JC, Jang HK, Lee H, Park S, Kim J, Kwon OS, Go YH, Jin Y, Kim W, Lee J, Bae S, Cha HJ. Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance. Biomaterials. 262: 120295. PMID 32916603 DOI: 10.1016/j.biomaterials.2020.120295  0.724
2020 Kwon OS, Lee H, Kong HJ, Kwon EJ, Park JE, Lee W, Kang S, Kim M, Kim W, Cha HJ. Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer. Oncogene. PMID 32388539 DOI: 10.1038/s41388-020-1316-2  0.735
2020 Kwon OS, Lee H, Kim YJ, Cha HJ, Song NY, Lee MO. ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis. Cancers. 12. PMID 32276460 DOI: 10.3390/cancers12040909  0.691
2019 Kwon T, Kwon OS, Cha HJ, Sung BJ. Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory. Scientific Reports. 9: 16297. PMID 31704971 DOI: 10.1038/s41598-019-52480-3  0.724
2019 Kim DH, Jang JH, Kwon OS, Cha HJ, Chun KS, Surh YJ. Nrf2-induced reductive stress favours self-renewal of breast cancer stem-like cells via the FoxO3a-Bmi-1 axis. Antioxidants & Redox Signaling. PMID 31672029 DOI: 10.1089/ars.2019.7730  0.738
2019 Kwon OS, Kim W, Cha HJ, Lee H. In silico drug repositioning: from large-scale transcriptome data to therapeutics. Archives of Pharmacal Research. PMID 31482491 DOI: 10.1007/s12272-019-01176-3  0.661
2019 Go YH, Lim C, Jeong HC, Kwon OS, Chung S, Lee H, Kim W, Suh YG, Son WS, Lee MO, Cha HJ, Kim SH. Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells. Frontiers in Chemistry. 7: 298. PMID 31157201 DOI: 10.3389/fchem.2019.00298  0.722
2018 Im JH, Hwang SI, Kim JW, Park SJ, Kang KR, You JS, Kim KP, Moon SH, Cha HJ, Chung HM, Schöler HR, Hyun JK, Han DW. Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells. Science Bulletin. 63: 477-487. PMID 36658808 DOI: 10.1016/j.scib.2018.02.023  0.313
2018 Go YH, Lee HJ, Kong HJ, Jeong HC, Lee DY, Hong SK, Sung SH, Kwon OS, Cha HJ. Screening of cytotoxic or cytostatic flavonoids with quantitative Fluorescent Ubiquitination-based Cell Cycle Indicator-based cell cycle assay. Royal Society Open Science. 5: 181303. PMID 30662739 DOI: 10.1098/rsos.181303  0.712
2018 Hong SK, Lee H, Kwon OS, Song NY, Lee HJ, Kang S, Kim JH, Kim M, Kim W, Cha HJ. Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer. Molecular Cancer. 17: 175. PMID 30563517 DOI: 10.1186/s12943-018-0924-8  0.711
2018 Cho SJ, Kim KT, Jeong HC, Park JC, Kwon OS, Song YH, Shin JG, Kang S, Kim W, Shin HD, Lee MO, Moon SH, Cha HJ. Selective Elimination of Culture-Adapted Human Embryonic Stem Cells with BH3 Mimetics. Stem Cell Reports. PMID 30293852 DOI: 10.1016/j.stemcr.2018.09.002  0.724
2018 Cho SJ, Kim KT, Kim JS, Kwon OS, Go YH, Kang NY, Heo H, Kim MR, Han DW, Moon SH, Chang YT, Cha HJ. A fluorescent chemical probe CDy9 selectively stains and enables the isolation of live naïve mouse embryonic stem cells. Biomaterials. 180: 12-23. PMID 30014963 DOI: 10.1016/J.Biomaterials.2018.07.007  0.711
2018 Cui YH, Kim H, Lee M, Yi JM, Kim RK, Uddin N, Yoo KC, Kang JH, Choi MY, Cha HJ, Kwon OS, Bae IH, Kim MJ, Kaushik N, Lee SJ. FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation. Oncogene. PMID 29973690 DOI: 10.1038/s41388-018-0372-3  0.709
2017 Kwon OS, Kwon SJ, Kim JS, Lee G, Maeng HJ, Lee J, Hwang GS, Cha HJ, Chun KH. Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects. Biomolecules & Therapeutics. PMID 29223142 DOI: 10.4062/biomolther.2017.115  0.673
2017 Kwon SJ, Kwon OS, Kim KT, Go YH, Yu SI, Lee BH, Miyoshi H, Oh E, Cho SJ, Cha HJ. Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii. Molecular Cancer. 16: 140. PMID 28830458 DOI: 10.1186/S12943-017-0703-Y  0.748
2017 Kwon OS, Han MJ, Cha HJ. Suppression of SIRT2 and altered acetylation status of human pluripotent stem cells: possible link to metabolic switch during reprogramming. Bmb Reports. PMID 28683850  0.706
2017 Kwon OS, Hong SK, Kwon SJ, Go YH, Oh E, Cha HJ. BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer. Cancer Letters. PMID 28606806 DOI: 10.1016/j.canlet.2017.05.019  0.746
2017 Kim I, Kim KS, Kwon OS, Cha HJ, Park KS. Ell3 stimulates 5-FU resistance in a breast cancer cell line. Oncology Letters. 13: 4173-4179. PMID 28588704 DOI: 10.3892/ol.2017.5996  0.751
2017 Jeong HC, Park SJ, Choi JJ, Go YH, Hong SK, Kwon OS, Shin JG, Kim RK, Lee MO, Lee SJ, Shin HD, Moon SH, Cha HJ. PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells by Enhancing the PI3K/AKT/SOX2 axis. Stem Cells (Dayton, Ohio). PMID 28543863 DOI: 10.1002/stem.2642  0.729
2017 Cho SJ, Cha BS, Kwon OS, Lim J, Shin DM, Han DW, Ishitani T, Jho EH, Fornace AJ, Cha HJ. Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. Biochimica Et Biophysica Acta. PMID 28185954 DOI: 10.1016/J.Bbadis.2017.01.028  0.769
2016 Cho SJ, Koo J, Chun KH, Cha HJ. Control of stress signaling in stem cells: crossroads of stem cells and cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 27460084 DOI: 10.1007/s13277-016-5249-x  0.341
2016 Kwon OS, Kim KT, Lee E, Kim M, Choi SH, Li H, Fornace AJ, Cho JH, Lee YS, Lee JS, Lee YJ, Cha HJ. Induction of MiR-21 by Stereotactic Body Radiotherapy Contributes to the Pulmonary Fibrotic Response. Plos One. 11: e0154942. PMID 27171163 DOI: 10.1371/Journal.Pone.0154942  0.72
2016 Hong SK, Park JR, Kwon OS, Kim KT, Bae GY, Cha HJ. Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells. Cancer Letters. PMID 27085460 DOI: 10.1016/j.canlet.2016.04.012  0.736
2015 Kwon OS, Oh E, Park JR, Lee JS, Bae GY, Koo JH, Kim H, Choi YL, Choi YS, Kim J, Cha HJ. GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma. Oncotarget. PMID 26544896 DOI: 10.18632/oncotarget.6019  0.712
2015 Lee JS, Park JR, Kwon OS, Lee TH, Nakano I, Miyoshi H, Chun KH, Park MJ, Lee HJ, Kim SU, Cha HJ. SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner. Neuro-Oncology. 17: 95-106. PMID 25096191 DOI: 10.1093/neuonc/nou145  0.74
2014 Lee JS, Park JR, Kwon OS, Kim H, Fornace AJ, Cha HJ. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. Journal of Dermatological Science. 73: 125-34. PMID 24126074 DOI: 10.1016/J.Jdermsci.2013.09.003  0.739
2013 Lee MO, Moon SH, Jeong HC, Yi JY, Lee TH, Shim SH, Rhee YH, Lee SH, Oh SJ, Lee MY, Han MJ, Cho YS, Chung HM, Kim KS, Cha HJ. Inhibition of pluripotent stem cell-derived teratoma formation by small molecules. Proceedings of the National Academy of Sciences of the United States of America. 110: E3281-90. PMID 23918355 DOI: 10.1073/pnas.1303669110  0.335
2013 Kim SH, Choe C, Shin YS, Jeon MJ, Choi SJ, Lee J, Bae GY, Cha HJ, Kim J. Human lung cancer-associated fibroblasts enhance motility of non-small cell lung cancer cells in co-culture. Anticancer Research. 33: 2001-9. PMID 23645749  0.339
2012 Lee JS, Bae GY, Lee MO, Cha HJ. Oncogenic challenges in stem cells and the link to cancer initiation. Archives of Pharmacal Research. 35: 235-44. PMID 22370778 DOI: 10.1007/s12272-012-0204-x  0.346
2012 Lowe J, Cha H, Lee MO, Mazur SJ, Appella E, Fornace AJ. Regulation of the Wip1 phosphatase and its effects on the stress response. Frontiers in Bioscience (Landmark Edition). 17: 1480-98. PMID 22201816 DOI: 10.2741/3999  0.665
2012 Lee JS, Lee HJ, Moon BH, Song SH, Lee MO, Shim SH, Kim HS, Lee MC, Kwon JT, Fornace AJ, Kim SU, Cha HJ. Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation. Stem Cell Reviews. 8: 532-45. PMID 21755312 DOI: 10.1007/S12015-011-9280-4  0.551
2012 Han SY, Lee CO, Ahn SH, Lee MO, Kang SY, Cha HJ, Cho SY, Ha JD, Ryu JW, Jung H, Kim HR, Koh JS, Lee J. Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo. Investigational New Drugs. 30: 518-23. PMID 21080208 DOI: 10.1007/S10637-010-9584-2  0.304
2011 Lee MO, Lee HJ, Kim MA, Kim EK, Lee JH, Heo JH, Lee SH, Cho SH, Fornace AJ, Jeong HC, Cha HJ. P16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation Journal of Thoracic Oncology. 6: 423-431. PMID 21164364 DOI: 10.1097/Jto.0B013E3182018Ace  0.511
2010 Kim JJ, Lee JS, Moon BH, Lee MO, Song SH, Li H, Fornace AJ, Cha HJ. Wip1-expressing feeder cells retain pluripotency of co-cultured mouse embryonic stem cells under leukemia inhibitory factor-deprivated condition Archives of Pharmacal Research. 33: 1253-1260. PMID 20803129 DOI: 10.1007/S12272-010-0816-Y  0.549
2010 Cha Y, Moon BH, Lee MO, Ahn HJ, Lee HJ, Lee KA, Fornace AJ, Kim KS, Cha HJ, Park KS. Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling Stem Cells. 28: 1476-1486. PMID 20641039 DOI: 10.1002/Stem.470  0.514
2010 Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ. Wip1 directly dephosphorylates γ-H2AX and attenuates the DNA damage response Cancer Research. 70: 4112-4122. PMID 20460517 DOI: 10.1158/0008-5472.Can-09-4244  0.63
2010 Lowe JM, Cha H, Yang Q, Fornace AJ. Nuclear factor-κB (NF-κB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase Journal of Biological Chemistry. 285: 5249-5257. PMID 20007970 DOI: 10.1074/Jbc.M109.034579  0.668
2009 Lee JS, Lee MO, Moon BH, Shim SH, Fornace AJ, Cha HJ. Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways Stem Cells. 27: 1963-1975. PMID 19544416 DOI: 10.1002/Stem.121  0.523
2007 Cha H, Wang X, Li H, Fornace AJ. A functional role for p38 MAPK in modulating mitotic transit in the absence of stress Journal of Biological Chemistry. 282: 22984-22992. PMID 17548358 DOI: 10.1074/Jbc.M700735200  0.47
2006 Cha H, Dangi S, Machamer CE, Shapiro P. Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells. Cellular Signalling. 18: 93-104. PMID 15923109 DOI: 10.1016/j.cellsig.2005.03.028  0.656
2004 Cha H, Smith BL, Gallo K, Machamer CE, Shapiro P. Phosphorylation of golgin-160 by mixed lineage kinase 3. Journal of Cell Science. 117: 751-60. PMID 14734651 DOI: 10.1242/Jcs.00897  0.588
2004 Cha H, Hancock C, Dangi S, Maiguel D, Carrier F, Shapiro P. Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies. The Biochemical Journal. 378: 857-65. PMID 14670079 DOI: 10.1042/BJ20031173  0.605
2004 Dangi S, Cha H, Shapiro P. Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cellular Signalling. 15: 667-75. PMID 12742227 DOI: 10.1016/s0898-6568(03)00002-0  0.624
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