Xing-Zhen Chen - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
 Physiology University of Alberta, Edmonton, Alberta, Canada 
Website:
https://www.ualberta.ca/membrane-biology/about/members/xing-zhen-chen.html

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu X, Wang Y, Weng Z, Xu Q, Zhou C, Tang J, Chen XZ. Inhibition of TRPP3 by calmodulin through Ca/calmodulin-dependent protein kinase II. Cell Insight. 2: 100088. PMID 37193065 DOI: 10.1016/j.cellin.2023.100088  0.364
2023 Cai R, Chen XZ. Roles of Intramolecular Interactions in the Regulation of TRP Channels. Reviews of Physiology, Biochemistry and Pharmacology. 186: 29-56. PMID 35882668 DOI: 10.1007/112_2022_74  0.791
2022 Liu X, Zhang R, Fatehi M, Wang Y, Long W, Tian R, Deng X, Weng Z, Xu Q, Light PE, Tang J, Chen XZ. Regulation of the PKD2 channel function by TACAN. The Journal of Physiology. PMID 36420836 DOI: 10.1113/JP283895  0.433
2022 Wang L, Cai R, Chen XZ, Peng JB. Molecular insights into the structural and dynamical changes of calcium channel TRPV6 induced by its interaction with phosphatidylinositol 4,5-bisphosphate. Journal of Biomolecular Structure & Dynamics. 1-10. PMID 35950523 DOI: 10.1080/07391102.2022.2109752  0.772
2022 Ahmed KT, Amin MR, Razmara P, Roy B, Cai R, Tang J, Chen XZ, Ali DW. Expression and development of TARP γ-4 in embryonic zebrafish. Developmental Neuroscience. PMID 35728564 DOI: 10.1159/000525578  0.697
2022 Huang Y, Li S, Liu Q, Wang Z, Li S, Liu L, Zhao W, Wang K, Zhang R, Wang L, Wang M, William Ali D, Michalak M, Chen XZ, Zhou C, et al. The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy. Cell Death & Disease. 13: 524. PMID 35665750 DOI: 10.1038/s41419-022-04977-5  0.426
2021 Cai R, Tang J, Chen XZ. Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel. Iscience. 24: 103395. PMID 34825147 DOI: 10.1016/j.isci.2021.103395  0.746
2021 Cai R, Wang L, Liu X, Michalak M, Tang J, Peng JB, Chen XZ. Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion. Communications Biology. 4: 990. PMID 34413465 DOI: 10.1038/s42003-021-02521-3  0.75
2020 Huang Y, Li S, Jia Z, Zhao W, Zhou C, Zhang R, Ali DW, Michalak M, Chen XZ, Tang J. Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy. Frontiers in Oncology. 10: 573127. PMID 33344232 DOI: 10.3389/fonc.2020.573127  0.352
2020 Huang Y, Li S, Jia Z, Li S, He W, Zhou C, Zhang R, Xu R, Sun B, Ali DW, Michalak M, Chen XZ, Tang J. TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination. Journal of Cellular Physiology. PMID 33037615 DOI: 10.1002/jcp.30065  0.427
2020 Cai R, Liu X, Zhang R, Hofmann L, Zheng W, Amin MR, Wang L, Hu Q, Peng JB, Michalak M, Flockerzi V, Ali DW, Chen XZ, Tang J. Autoinhibition of TRPV6 Channel and Regulation by PIP2. Iscience. 23: 101444. PMID 32829285 DOI: 10.1016/J.Isci.2020.101444  0.783
2019 Wang Z, Ng C, Liu X, Wang Y, Li B, Kashyap P, Chaudhry HA, Castro A, Kalontar EM, Ilyayev L, Walker R, Alexander RT, Qian F, Chen XZ, Yu Y. The ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex. Embo Reports. e48336. PMID 31441214 DOI: 10.15252/Embr.201948336  0.488
2019 Wang L, Jiang C, Cai R, Chen XZ, Peng JB. Unveiling the distinct mechanisms by which disease-causing mutations in the Kelch domain of KLHL3 disrupt the interaction with the acidic motif of WNK4 through molecular dynamics simulation. Biochemistry. PMID 30931564 DOI: 10.1021/acs.biochem.9b00066  0.712
2019 Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ. Author Correction: Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nature Communications. 10: 1452. PMID 30914650 DOI: 10.1038/S41467-019-09422-4  0.727
2018 Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nature Communications. 9: 2302. PMID 29899465 DOI: 10.1038/S41467-018-04586-X  0.786
2018 Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, ... Chen XZ, et al. Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2. Cell Reports. 22: 1560-1573. PMID 29425510 DOI: 10.1016/J.Celrep.2018.01.042  0.781
2017 Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J, Light P, Flockerzi V, Cao Y, Chen XZ. Identification and characterization of hydrophobic gate residues in TRP channels. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28970257 DOI: 10.1096/fj.201700599RR  0.782
2017 Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V. The S4---S5 linker - gearbox of TRP channel gating. Cell Calcium. PMID 28416203 DOI: 10.1016/j.ceca.2017.04.002  0.514
2016 Zheng W, Yang J, Beauchamp E, Cai R, Hussein S, Hofmann L, Li Q, Flockerzi V, Berthiaume LG, Tang J, Chen XZ. Regulation of TRPP3 channel function by N-terminal domain palmitoylation and phosphorylation. The Journal of Biological Chemistry. PMID 27754867 DOI: 10.1074/Jbc.M116.756544  0.772
2015 Hussein S, Zheng W, Dyte C, Wang Q, Yang J, Zhang F, Tang J, Cao Y, Chen XZ. Acid-induced off-response of PKD2L1 channel in Xenopus oocytes and its regulation by Ca(2.). Scientific Reports. 5: 15752. PMID 26502994 DOI: 10.1038/srep15752  0.306
2015 Schorr S, Klein MC, Gamayun I, Melnyk A, Jung M, Schäuble N, Wang Q, Hemmis B, Bochen F, Greiner M, Lampel P, Urban SK, Hassdenteufel S, Dudek J, Chen XZ, et al. Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum. The Journal of Biological Chemistry. 290: 18621-35. PMID 26085089 DOI: 10.1074/jbc.M115.636639  0.391
2015 Zheng W, Hussein S, Yang J, Huang J, Zhang F, Hernandez-Anzaldo S, Fernandez-Patron C, Cao Y, Zeng H, Tang J, Chen XZ. A novel PKD2L1 C-terminal domain critical for trimerization and channel function. Scientific Reports. 5: 9460. PMID 25820328 DOI: 10.1038/Srep09460  0.499
2012 Wang Q, Dai XQ, Li Q, Tuli J, Liang G, Li SS, Chen XZ. Filamin interacts with epithelial sodium channel and inhibits its channel function. The Journal of Biological Chemistry. 288: 264-73. PMID 23161538 DOI: 10.1074/jbc.M112.396408  0.482
2012 Wang Q, Dai XQ, Li Q, Wang Z, Cantero Mdel R, Li S, Shen J, Tu JC, Cantiello H, Chen XZ. Structural interaction and functional regulation of polycystin-2 by filamin. Plos One. 7: e40448. PMID 22802962 DOI: 10.1371/Journal.Pone.0040448  0.523
2011 Yang J, Wang Q, Zheng W, Tuli J, Li Q, Wu Y, Hussein S, Dai XQ, Shafiei S, Li XG, Shen PY, Tu JC, Chen XZ. Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction. The Journal of Biological Chemistry. 287: 6551-61. PMID 22174419 DOI: 10.1074/jbc.M111.305854  0.517
2009 Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 11558-63. PMID 19556541 DOI: 10.1073/Pnas.0903684106  0.301
2009 Raychowdhury MK, Ramos AJ, Zhang P, McLaughin M, Dai XQ, Chen XZ, Montalbetti N, Del Rocío Cantero M, Ausiello DA, Cantiello HF. Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. American Journal of Physiology. Renal Physiology. 296: F87-97. PMID 18945824 DOI: 10.1152/Ajprenal.90509.2008  0.315
2008 Chen XZ, Li Q, Wu Y, Liang G, Lara CJ, Cantiello HF. Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton. The Febs Journal. 275: 4675-83. PMID 18754774 DOI: 10.1111/j.1742-4658.2008.06616.x  0.334
2008 Liang G, Li Q, Tang Y, Kokame K, Kikuchi T, Wu G, Chen XZ. Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Human Molecular Genetics. 17: 1109-19. PMID 18178578 DOI: 10.1093/hmg/ddm383  0.304
2007 Cantiello HF, Montalbetti N, Li Q, Chen XZ. The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism: Lessons from Polycystin-2 (TRPP2). Current Topics in Membranes. 59: 233-96. PMID 25168140 DOI: 10.1016/S1063-5823(06)59010-6  0.481
2007 Li Q, Dai XQ, Shen PY, Wu Y, Long W, Chen CX, Hussain Z, Wang S, Chen XZ. Direct binding of alpha-actinin enhances TRPP3 channel activity. Journal of Neurochemistry. 103: 2391-400. PMID 17944866 DOI: 10.1111/j.1471-4159.2007.04940.x  0.35
2007 Dai XQ, Ramji A, Liu Y, Li Q, Karpinski E, Chen XZ. Inhibition of TRPP3 channel by amiloride and analogs. Molecular Pharmacology. 72: 1576-85. PMID 17804601 DOI: 10.1124/mol.107.037150  0.388
2007 Montalbetti N, Li Q, Wu Y, Chen XZ, Cantiello HF. Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures. The Journal of Physiology. 579: 717-28. PMID 17204494 DOI: 10.1113/jphysiol.2006.125583  0.429
2007 Li F, Dai XQ, Li Q, Wu Y, Chen XZ. Inhibition of polycystin-L channel by the Chinese herb Sparganum stoloniferum Buch.-Ham. Canadian Journal of Physiology and Pharmacology. 84: 923-7. PMID 17111037 DOI: 10.1139/y06-040  0.423
2006 Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ. Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. Human Molecular Genetics. 15: 3280-92. PMID 17008358 DOI: 10.1093/hmg/ddl404  0.317
2006 Li Q, Montalbetti N, Wu Y, Ramos A, Raychowdhury MK, Chen XZ, Cantiello HF. Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells. The Journal of Biological Chemistry. 281: 37566-75. PMID 16950792 DOI: 10.1074/jbc.M603643200  0.362
2006 Dai XQ, Karpinski E, Chen XZ. Permeation and inhibition of polycystin-L channel by monovalent organic cations. Biochimica Et Biophysica Acta. 1758: 197-205. PMID 16564495 DOI: 10.1016/j.bbamem.2006.01.020  0.426
2005 Montalbetti N, Li Q, González-Perrett S, Semprine J, Chen XZ, Cantiello HF. Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast. PflüGers Archiv : European Journal of Physiology. 451: 294-303. PMID 16025301 DOI: 10.1007/s00424-005-1458-7  0.373
2005 Montalbetti N, Li Q, Timpanaro GA, González-Perrett S, Dai XQ, Chen XZ, Cantiello HF. Cytoskeletal regulation of calcium-permeable cation channels in the human syncytiotrophoblast: role of gelsolin. The Journal of Physiology. 566: 309-25. PMID 15845576 DOI: 10.1113/jphysiol.2005.087072  0.379
2004 Li Q, Dai XQ, Shen PY, Cantiello HF, Karpinski E, Chen XZ. A modified mammalian tandem affinity purification procedure to prepare functional polycystin-2 channel. Febs Letters. 576: 231-6. PMID 15474043 DOI: 10.1016/j.febslet.2004.09.017  0.315
2003 Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ. Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. Biochemistry. 42: 7618-25. PMID 12809519 DOI: 10.1021/Bi034210A  0.425
2002 Liu Y, Li Q, Tan M, Zhang YY, Karpinski E, Zhou J, Chen XZ. Modulation of the human polycystin-L channel by voltage and divalent cations. Febs Letters. 525: 71-6. PMID 12163164 DOI: 10.1016/S0014-5793(02)03071-5  0.38
2002 Li Q, Liu Y, Zhao W, Chen XZ. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. Febs Letters. 516: 270-8. PMID 11959145 DOI: 10.1016/S0014-5793(02)02513-9  0.419
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