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Karen A. Kirby - Publications

Affiliations: 
2007 University of Missouri - Columbia, Columbia, MO, United States 
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sun Q, Biswas A, Vijayan RSK, Craveur P, Forli S, Olson AJ, Castaner AE, Kirby KA, Sarafianos SG, Deng N, Levy R. Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid. Journal of Computer-Aided Molecular Design. PMID 35262811 DOI: 10.1007/s10822-022-00446-5  0.345
2022 Selyutina A, Simons LM, Kirby KA, Bulnes-Ramos A, Hu P, Sarafianos SG, Hultquist JF, Diaz-Griffero F. TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. Viruses. 14. PMID 35215956 DOI: 10.3390/v14020363  0.374
2021 McFadden WM, Snyder AA, Kirby KA, Tedbury PR, Raj M, Wang Z, Sarafianos SG. Rotten to the core: antivirals targeting the HIV-1 capsid core. Retrovirology. 18: 41. PMID 34937567 DOI: 10.1186/s12977-021-00583-z  0.423
2021 Sahani RL, Diana-Rivero R, Vernekar SKV, Wang L, Du H, Zhang H, Castaner AE, Casey MC, Kirby KA, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74. Viruses. 13. PMID 33804121 DOI: 10.3390/v13030479  0.314
2021 Cilento ME, Kirby KA, Sarafianos SG. Avoiding Drug Resistance in HIV Reverse Transcriptase. Chemical Reviews. PMID 33507067 DOI: 10.1021/acs.chemrev.0c00967  0.391
2020 Vernekar SKV, Sahani RL, Casey MC, Kankanala J, Wang L, Kirby KA, Du H, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules. Viruses. 12. PMID 32316297 DOI: 10.3390/V12040452  0.355
2019 Craveur P, Gres AT, Kirby KA, Liu D, Hammond JA, Deng Y, Forli S, Goodsell DS, Williamson JR, Sarafianos SG, Olson AJ. Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. Mbio. 10. PMID 30862755 DOI: 10.1128/Mbio.02858-18  0.31
2019 Tang J, Do HT, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Parniak MA, Sarafianos SG, Wang Z. Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. European Journal of Medicinal Chemistry. 166: 390-399. PMID 30739822 DOI: 10.1016/J.Ejmech.2019.01.081  0.43
2018 Huber AD, Pineda DL, Liu D, Boschert KN, Gres AT, Wolf JJ, Coonrod EM, Tang J, Laughlin TG, Yang Q, Puray-Chavez M, Ji J, Singh K, Kirby KA, Wang Z, et al. Novel Hepatitis B Virus Capsid-Targeting Antiviral that Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores. Acs Infectious Diseases. PMID 30582687 DOI: 10.1021/Acsinfecdis.8B00235  0.32
2018 Wang L, Tang J, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Parniak MA, Sarafianos SG, Wang Z. 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. European Journal of Medicinal Chemistry. 156: 680-691. PMID 30031978 DOI: 10.1016/J.Ejmech.2018.07.035  0.439
2018 Wang L, Tang J, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Xie J, Parniak MA, Sarafianos SG, Wang Z. 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity. European Journal of Medicinal Chemistry. 156: 652-665. PMID 30031976 DOI: 10.1016/J.Ejmech.2018.07.039  0.411
2017 Kankanala J, Kirby KA, Huber AD, Casey MC, Wilson DJ, Sarafianos SG, Wang Z. Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H. European Journal of Medicinal Chemistry. 141: 149-161. PMID 29031062 DOI: 10.1016/J.Ejmech.2017.09.054  0.419
2017 Kirby KA, Myshakina NA, Christen MT, Chen YL, Schmidt HA, Huber AD, Xi Z, Kim S, Rao RK, Kramer ST, Yang Q, Singh K, Parniak MA, Wang Z, Ishima R, et al. A 2-hydroxyisoquinoline-1,3-dione active site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. PMID 28760905 DOI: 10.1128/Aac.01351-17  0.445
2017 Hachiya A, Kirby KA, Ido Y, Shigemi U, Matsuda M, Okazaki R, Imamura J, Sarafianos SG, Yokomaku Y, Iwatani Y. Impact of HIV-1 Integrase L74F/V75I Mutations from a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors. Antimicrobial Agents and Chemotherapy. PMID 28533248 DOI: 10.1128/Aac.00315-17  0.443
2017 Vernekar SKV, Tang J, Wu B, Huber AD, Casey MC, Myshakina NS, Wilson DJ, Kankanala J, Kirby KA, Parniak MA, Sarafianos SG, Wang Z. Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity. Journal of Medicinal Chemistry. PMID 28525279 DOI: 10.1021/Acs.Jmedchem.7B00440  0.473
2017 Huber AD, Michailidis E, Tang J, Puray-Chavez MN, Boftsi M, Wolf JJ, Boschert KN, Sheridan MA, Leslie MD, Kirby KA, Singh K, Mitsuya H, Parniak MA, Wang Z, Sarafianos SG. 3-hydroxypyrimidine-2,4-diones as novel hepatitis B virus antivirals targeting the viral ribonuclease H. Antimicrobial Agents and Chemotherapy. PMID 28320718 DOI: 10.1128/Aac.00245-17  0.325
2017 Tang J, Kirby KA, Huber AD, Casey MC, Ji J, Wilson DJ, Sarafianos SG, Wang Z. 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase. European Journal of Medicinal Chemistry. 128: 168-179. PMID 28182989 DOI: 10.1016/J.Ejmech.2017.01.041  0.4
2016 Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proceedings of the National Academy of Sciences of the United States of America. PMID 27489345 DOI: 10.1073/Pnas.1605223113  0.4
2016 Kankanala J, Kirby KA, Liu F, Miller LG, Nagy E, Wilson DJ, Parniak MA, Sarafianos SG, Wang Z. Design, Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H. Journal of Medicinal Chemistry. PMID 27094954 DOI: 10.1021/Acs.Jmedchem.6B00465  0.499
2016 Tang J, Liu F, Nagy E, Miller LG, Kirby KA, Wilson DJ, Wu B, Sarafianos SG, Parniak MA, Wang Z. 2-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. Journal of Medicinal Chemistry. PMID 26927866 DOI: 10.1021/Acs.Jmedchem.5B01879  0.484
2015 Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG. STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability. Science (New York, N.Y.). 349: 99-103. PMID 26044298 DOI: 10.1126/Science.Aaa5936  0.325
2015 Vernekar SK, Liu Z, Nagy E, Miller L, Kirby KA, Wilson DJ, Kankanala J, Sarafianos SG, Parniak MA, Wang Z. Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. Journal of Medicinal Chemistry. 58: 651-64. PMID 25522204 DOI: 10.1021/Jm501132S  0.431
2015 Kirby KA, Ong YT, Hachiya A, Laughlin TG, Chiang LA, Pan Y, Moran JL, Marchand B, Singh K, Gallazzi F, Quinn TP, Yoshimura K, Murakami T, Matsushita S, Sarafianos SG. Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 70-80. PMID 25351987 DOI: 10.1096/Fj.14-252262  0.394
2014 Singh K, Flores JA, Kirby KA, Neogi U, Sonnerborg A, Hachiya A, Das K, Arnold E, McArthur C, Parniak M, Sarafianos SG. Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors. Viruses. 6: 3535-62. PMID 25254383 DOI: 10.3390/V6093535  0.481
2014 Michailidis E, Huber AD, Ryan EM, Ong YT, Leslie MD, Matzek KB, Singh K, Marchand B, Hagedorn AN, Kirby KA, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. The Journal of Biological Chemistry. 289: 24533-48. PMID 24970894 DOI: 10.1074/Jbc.M114.562694  0.514
2014 Huber AD, Michailidis E, Schultz ML, Ong YT, Bloch N, Puray-Chavez MN, Leslie MD, Ji J, Lucas AD, Kirby KA, Landau NR, Sarafianos SG. SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors. Antimicrobial Agents and Chemotherapy. 58: 4915-9. PMID 24867973 DOI: 10.1128/Aac.02745-14  0.491
2014 Gres A, Kirby K, Hachiya A, Michailidis E, Pornillos O, Sugiura W, Lee K, KewalRamani V, Tanner J, Sarafianos S. Native Hexameric Full-Length HIV-1 Capsid: Crystal Structure and Drug Targeting Acta Crystallographica Section a Foundations and Advances. 70: C696-C696. DOI: 10.1107/S2053273314093036  0.409
2013 Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG. Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrobial Agents and Chemotherapy. 57: 6254-64. PMID 24100493 DOI: 10.1128/Aac.01703-13  0.429
2013 Michailidis E, Ryan EM, Hachiya A, Kirby KA, Marchand B, Leslie MD, Huber AD, Ong YT, Jackson JC, Singh K, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Retrovirology. 10: 65. PMID 23800377 DOI: 10.1186/1742-4690-10-65  0.515
2013 Lee JH, Hachiya A, Shin SK, Lee J, Gatanaga H, Oka S, Kirby KA, Ong YT, Sarafianos SG, Folk WR, Yoo W, Hong SP, Kim SO. Restriction fragment mass polymorphism (RFMP) analysis based on MALDI-TOF mass spectrometry for detecting antiretroviral resistance in HIV-1 infected patients. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 19: E263-70. PMID 23480551 DOI: 10.1111/1469-0691.12167  0.465
2012 Michailidis E, Singh K, Ryan EM, Hachiya A, Ong YT, Kirby KA, Marchand B, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant. Cellular and Molecular Biology (Noisy-Le-Grand, France). 58: 187-95. PMID 23273211 DOI: 10.1170/T940  0.511
2012 Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG. Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop. Cellular and Molecular Biology (Noisy-Le-Grand, France). 58: 71-9. PMID 23273194 DOI: 10.1170/T923  0.436
2012 Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. The Journal of Biological Chemistry. 287: 29988-99. PMID 22761416 DOI: 10.1074/Jbc.M112.351551  0.408
2012 Michailidis E, Kirby KA, Hachiya A, Yoo W, Hong SP, Kim SO, Folk WR, Sarafianos SG. Antiviral therapies: focus on hepatitis B reverse transcriptase. The International Journal of Biochemistry & Cell Biology. 44: 1060-71. PMID 22531713 DOI: 10.1016/J.Biocel.2012.04.006  0.351
2012 Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG. Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase. Antimicrobial Agents and Chemotherapy. 56: 2048-61. PMID 22252812 DOI: 10.1128/Aac.06000-11  0.489
2012 Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, et al. Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Nucleic Acids Research. 40: 345-59. PMID 21908397 DOI: 10.1093/Nar/Gkr694  0.534
2011 Kirby KA, Singh K, Michailidis E, Marchand B, Kodama EN, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Cellular and Molecular Biology (Noisy-Le-Grand, France). 57: 40-6. PMID 21366961 DOI: 10.1170/T900  0.404
2011 Hachiya A, Kodama EN, Schuckmann MM, Kirby KA, Michailidis E, Sakagami Y, Oka S, Singh K, Sarafianos SG. K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism. Plos One. 6: e16242. PMID 21249155 DOI: 10.1371/Journal.Pone.0016242  0.462
2010 Schuckmann MM, Marchand B, Hachiya A, Kodama EN, Kirby KA, Singh K, Sarafianos SG. The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. The Journal of Biological Chemistry. 285: 38700-9. PMID 20876531 DOI: 10.1074/Jbc.M110.153783  0.412
2010 Singh K, Marchand B, Kirby KA, Michailidis E, Sarafianos SG. Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase. Viruses. 2: 606-638. PMID 20376302 DOI: 10.3390/V2020606  0.465
2009 Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor. The Journal of Biological Chemistry. 284: 35681-91. PMID 19837673 DOI: 10.1074/Jbc.M109.036616  0.501
2007 Thallapally PK, Kirby KA, Atwood JL. Comparison of porous and nonporous materials for methane storage New Journal of Chemistry. 31: 628-630. DOI: 10.1039/B610321A  0.332
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