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Erin J. Whalen, Ph.D. - Publications

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
mood, thirst, cardiovascular homeostasis
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Whalen EJ, Johnson AK, Lewis SJ. Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats. Microvascular Research. 91: 22-9. PMID 24246569 DOI: 10.1016/j.mvr.2013.11.001  0.345
2012 Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG, Moseley MA, Telen MJ. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. Blood. 119: 1217-27. PMID 22147898 DOI: 10.1182/Blood-2011-03-344440  0.404
2011 Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53. PMID 21857681 DOI: 10.1038/Nature10368  0.721
2011 Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC. Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circulation. Heart Failure. 4: 770-8. PMID 21835984 DOI: 10.1161/Circheartfailure.111.962571  0.737
2011 Whalen EJ, Rajagopal S, Lefkowitz RJ. Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends in Molecular Medicine. 17: 126-39. PMID 21183406 DOI: 10.1016/J.Molmed.2010.11.004  0.768
2010 Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9. PMID 20801892 DOI: 10.1124/Jpet.110.173005  0.798
2009 Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Science Signaling. 2: ra33. PMID 19584355 DOI: 10.1126/Scisignal.2000444  0.762
2009 Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 9649-54. PMID 19497875 DOI: 10.1073/Pnas.0904361106  0.858
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/Jci36806  0.804
2008 Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14555-60. PMID 18787115 DOI: 10.1073/Pnas.0804745105  0.856
2008 Ozawa K, Whalen EJ, Nelson CD, Mu Y, Hess DT, Lefkowitz RJ, Stamler JS. S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Molecular Cell. 31: 395-405. PMID 18691971 DOI: 10.1016/J.Molcel.2008.05.024  0.845
2008 Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 9988-93. PMID 18621717 DOI: 10.1073/Pnas.0804246105  0.877
2008 Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ. Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 21093-101. PMID 18534983 DOI: 10.1074/Jbc.M800431200  0.847
2008 Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (New York, N.Y.). 320: 1777-81. PMID 18497258 DOI: 10.1126/Science.1157983  0.862
2008 DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ. Beta-arrestin-mediated signaling regulates protein synthesis. The Journal of Biological Chemistry. 283: 10611-20. PMID 18276584 DOI: 10.1074/Jbc.M710515200  0.869
2008 Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ. beta-arrestin-biased agonism at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 5669-76. PMID 18086673 DOI: 10.1074/Jbc.M708118200  0.874
2007 Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/Pnas.0707936104  0.847
2007 Zennadi R, Moeller BJ, Whalen EJ, Batchvarova M, Xu K, Shan S, Delahunty M, Dewhirst MW, Telen MJ. Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. Blood. 110: 2708-17. PMID 17609430 DOI: 10.1182/Blood-2006-11-056101  0.486
2007 Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 129: 511-22. PMID 17482545 DOI: 10.1016/J.Cell.2007.02.046  0.854
2007 Whalen EJ, Lewis SJ, Johnson AK. Hemodynamic responses elicited by gamma2-MSH or blood replacement in hemorrhaged rats. The Journal of Surgical Research. 139: 121-7. PMID 17336330 DOI: 10.1016/j.jss.2006.09.025  0.356
2006 Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Molecular Cell. 24: 643-52. PMID 17157248 DOI: 10.1016/J.Molcel.2006.11.007  0.838
2006 Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 16284-9. PMID 17060617 DOI: 10.1073/Pnas.0607583103  0.848
2006 Whalen EJ, Saurer TB, Johnson AK, Lewis SJ. Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals. Vascular Pharmacology. 45: 102-11. PMID 16697265 DOI: 10.1016/j.vph.2006.03.006  0.415
2006 Whalen EJ, Bates JN, Johnson AK, Lewis SJ. Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis. British Journal of Pharmacology. 147: 755-64. PMID 16474417 DOI: 10.1038/sj.bjp.0706675  0.655
2006 Nozik-Grayck E, Whalen EJ, Stamler JS, McMahon TJ, Chitano P, Piantadosi CA. S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L136-43. PMID 16126786 DOI: 10.1152/Ajplung.00230.2005  0.439
2005 Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 1442-7. PMID 15671181 DOI: 10.1073/Pnas.0409532102  0.863
2004 Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ. PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. Cellular Signalling. 16: 1397-403. PMID 15381255 DOI: 10.1016/J.Cellsig.2004.05.002  0.829
2004 Lefkowitz RJ, Whalen EJ. beta-arrestins: traffic cops of cell signaling. Current Opinion in Cell Biology. 16: 162-8. PMID 15196559 DOI: 10.1016/J.Ceb.2004.01.001  0.763
2004 Zennadi R, Whalen EJ, Telen MJ. Protein Kinases Associated with Activation of Sickle Red Blood Cell Adhesion. Blood. 104: 3567-3567. DOI: 10.1182/Blood.V104.11.3567.3567  0.376
2003 Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. The Journal of Biological Chemistry. 278: 26295-301. PMID 12724327 DOI: 10.1074/Jbc.M212352200  0.861
2001 Whalen EJ, Schoorlemmer GH, Beltz TG, Johnson AK, Lewis SJ. Effects of chronic lesions of the anteroventral region of the third ventricle on cardiac beta-adrenoceptor function in conscious rats. Brain Research. 913: 82-5. PMID 11532250 DOI: 10.1016/S0006-8993(01)02744-5  0.609
2000 Whalen EJ, Johnson AK, Lewis SJ. Beta-adrenoceptor dysfunction after inhibition of NO synthesis. Hypertension. 36: 376-82. PMID 10988268 DOI: 10.1161/01.HYP.36.3.376  0.498
2000 Whalen EJ, Johnson AK, Lewis SJ. Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold-Jarisch reflex. Brain Research. 873: 302-5. PMID 10930559 DOI: 10.1016/S0006-8993(00)02526-9  0.406
1999 Whalen EJ, Travis MD, Johnson AK, Lewis SJ. Rapid tachyphylaxis to hemodynamic effects of PACAP-27 after inhibition of nitric oxide synthesis. American Journal of Physiology. Heart and Circulatory Physiology. 276: H2117-H2126. PMID 29592378 DOI: 10.1152/ajpheart.1999.276.6.H2117  0.383
1999 Whalen EJ, Johnson AK, Lewis SJ. Tachyphylaxis to PACAP-27 after inhibition of NO synthesis: a loss of adenylate cyclase activation. The American Journal of Physiology. 277: R1453-61. PMID 10564219 DOI: 10.1152/Ajpregu.1999.277.5.R1453  0.434
1999 Whalen EJ, Lewis SJ. In vivo evidence that isoproterenol may increase heart rate in the rat by mechanisms in addition to activation of cardiac beta(1)- or beta(2)-adrenoceptors. European Journal of Pharmacology. 382: 207-10. PMID 10556671 DOI: 10.1016/S0014-2999(99)00631-7  0.498
1999 Whalen EJ, Beltz TG, Lewis SJ, Johnson AK. Periventricular anteroventral third ventricle lesions diminish the pressor response produced by systemic injection of the N-methyl-D-aspartate receptor antagonist MK-801. Brain Research. 836: 210-2. PMID 10415421 DOI: 10.1016/S0006-8993(99)01595-4  0.393
1999 Lewis SJ, Whalen EJ, Beltz TG, Johnson AK. Effects of chronic lesions of the anteroventral third ventricle region on baroreceptor reflex function in conscious rats. Brain Research. 835: 330-3. PMID 10415390 DOI: 10.1016/S0006-8993(99)01561-9  0.323
1999 Whalen EJ, Travis MD, Johnson AK, Lewis SJ. Rapid tachyphylaxis to hemodynamic effects of PACAP-27 after inhibition of nitric oxide synthesis. The American Journal of Physiology. 276: H2117-26. PMID 10362695 DOI: 10.1152/Ajpheart.1999.276.6.H2117  0.376
1999 Lewis SJ, Whalen EJ, Beltz TG, Johnson AK. Role of the anterior region of the third ventricle in the cardiovascular responses produced by systemic injection of a nitric oxide synthase inhibitor. Brain Research. 830: 191-4. PMID 10350574 DOI: 10.1016/S0006-8993(99)01351-7  0.345
1999 Whalen EJ, Beltz TG, Lewis SJ, Johnson AK. AV3V lesions attenuate the cardiovascular responses produced by blood-borne excitatory amino acid analogs. The American Journal of Physiology. 276: H1409-15. PMID 10330222 DOI: 10.1152/Ajpheart.1999.276.5.H1409  0.386
1999 Whalen EJ, Johnson AK, Lewis SJ. Effects of nitric oxide synthase inhibition on sympathetically-mediated tachycardia. European Journal of Pharmacology. 365: 217-23. PMID 9988105 DOI: 10.1016/S0014-2999(98)00853-X  0.499
1999 Whalen EJ, Johnson AK, Lewis SJ. Hemodynamic actions of systemically injected pituitary adenylate cyclase activating polypeptide-27 in the rat. European Journal of Pharmacology. 365: 205-15. PMID 9988104 DOI: 10.1016/S0014-2999(98)00852-8  0.437
1998 Whalen EJ, Johnson AK, Lewis SJ. Blockade of beta-adrenoceptors enhances cAMP signal transduction in vivo. European Journal of Pharmacology. 355: 189-93. PMID 9760033 DOI: 10.1016/S0014-2999(98)00517-2  0.547
1997 Travis MD, Whalen EJ, Lewis SJ. Heterologous desensitization of beta-adrenoceptor signal transduction in vivo. European Journal of Pharmacology. 328: R1-3. PMID 9203576 DOI: 10.1016/S0014-2999(97)83035-X  0.44
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