| Year |
Citation |
Score |
| 2023 |
Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society. PMID 37104712 DOI: 10.1021/jacs.2c12240 |
0.734 |
|
| 2022 |
Tang Y, Kay A, Jiang Z, Arkin MR. LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface. Biochemistry. 61: 2295-2302. PMID 36264309 DOI: 10.1021/acs.biochem.2c00482 |
0.735 |
|
| 2020 |
Chen KL, Lai CY, Pham MT, Chein RJ, Tang Y, Lin HC. Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis. Organic Letters. PMID 32243182 DOI: 10.1021/acs.orglett.0c01132 |
0.407 |
|
| 2020 |
Yan Y, Liu N, Tang Y. Recent developments in self-resistance gene directed natural product discovery. Natural Product Reports. PMID 31912842 DOI: 10.1039/c9np00050j |
0.312 |
|
| 2020 |
Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Molecular Neurodegeneration. 15: 2. PMID 31906970 DOI: 10.1186/S13024-019-0354-0 |
0.527 |
|
| 2019 |
Kishimoto S, Tsunematsu Y, Matsushita T, Hara K, Hashimoto H, Tang Y, Watanabe K. Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis. Biochemistry. PMID 31486637 DOI: 10.1021/Acs.Biochem.9B00702 |
0.49 |
|
| 2019 |
Yee DA, DeNicola AB, Billingsley JM, Creso JG, Subrahmanyam V, Tang Y. Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae. Metabolic Engineering. PMID 31226348 DOI: 10.1016/j.ymben.2019.06.004 |
0.38 |
|
| 2019 |
Billingsley JM, Anguiano JL, Tang Y. Production of semi-biosynthetic nepetalactone in yeast. Journal of Industrial Microbiology & Biotechnology. PMID 31165969 DOI: 10.1007/s10295-019-02199-x |
0.393 |
|
| 2019 |
Hai Y, Huang AM, Tang Y. Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi. Proceedings of the National Academy of Sciences of the United States of America. PMID 31061132 DOI: 10.1073/Pnas.1903282116 |
0.435 |
|
| 2019 |
Tang MC, Fischer CR, Chari JV, Tan D, Suresh S, Chu A, Miranda M, Smith J, Zhang Z, Garg N, St Onge RP, Tang Y. Thioesterase-catalyzed aminoacylation and thiolation of polyketides in fungi. Journal of the American Chemical Society. PMID 31051070 DOI: 10.1021/Jacs.9B01083 |
0.407 |
|
| 2019 |
Zhao Z, Ying Y, Hung YS, Tang Y. Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial. Journal of Natural Products. PMID 30908040 DOI: 10.1021/acs.jnatprod.8b00983 |
0.34 |
|
| 2019 |
Zhang Z, Jamieson CS, Zhao YL, Li D, Ohashi M, Houk KN, Tang Y. Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H. Journal of the American Chemical Society. PMID 30905148 DOI: 10.1021/Jacs.9B02204 |
0.322 |
|
| 2019 |
Chen M, Liu Q, Gao SS, Young AE, Jacobsen SE, Tang Y. Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant. Proceedings of the National Academy of Sciences of the United States of America. PMID 30842286 DOI: 10.1073/Pnas.1819998116 |
0.374 |
|
| 2019 |
Tan D, Jamieson CS, Ohashi M, Tang MC, Houk KN, Tang Y. Genome-mined Diels-Alderase catalyzes formation of the cis-octahydrodecalins of varicidin A and B. Journal of the American Chemical Society. PMID 30609896 DOI: 10.1021/Jacs.8B12010 |
0.375 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Tang Y, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.366 |
|
| 2018 |
Jamieson CS, Ohashi M, Liu F, Tang Y, Houk KN. The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery. Natural Product Reports. PMID 30311924 DOI: 10.1039/C8Np00075A |
0.33 |
|
| 2018 |
Hu Y, Tang Y. Biotransformation and biosynthesis of natural products. Journal of Asian Natural Products Research. 1-2. PMID 30274529 DOI: 10.1080/10286020.2018.1497464 |
0.33 |
|
| 2018 |
Bond CM, Tang Y. Engineering Saccharomyces cerevisiae for production of simvastatin. Metabolic Engineering. PMID 30213650 DOI: 10.1016/j.ymben.2018.09.005 |
0.348 |
|
| 2018 |
Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K. Enzymatic one-step ring contraction for quinolone biosynthesis. Nature Communications. 9: 2826. PMID 30026518 DOI: 10.1038/S41467-018-05221-5 |
0.463 |
|
| 2018 |
Yan Y, Liu Q, Zang X, Yuan S, Bat-Erdene U, Nguyen C, Gan J, Zhou J, Jacobsen SE, Tang Y. Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature. PMID 29995859 DOI: 10.1038/S41586-018-0319-4 |
0.382 |
|
| 2018 |
Ippoliti FM, Barber JS, Tang Y, Garg NK. Synthesis of 8-Hydroxygeraniol. The Journal of Organic Chemistry. PMID 29969566 DOI: 10.1021/Acs.Joc.8B01544 |
0.307 |
|
| 2018 |
Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, ... ... Tang Y, et al. HEx: A heterologous expression platform for the discovery of fungal natural products. Science Advances. 4: eaar5459. PMID 29651464 DOI: 10.1126/Sciadv.Aar5459 |
0.532 |
|
| 2018 |
Hai Y, Tang Y. Biosynthesis of long-chain N-acyl amide by a truncated PKS-NRPS hybrid megasynthase in fungi. Journal of the American Chemical Society. PMID 29343058 DOI: 10.1021/Jacs.7B13350 |
0.393 |
|
| 2018 |
Wertz I, Kategaya L, Lello PD, Rouge L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton J, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, ... ... Tang Y, et al. Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Sy23-03 |
0.631 |
|
| 2017 |
Walsh CT, Tu BP, Tang Y. Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism. Chemical Reviews. PMID 29272116 DOI: 10.1021/Acs.Chemrev.7B00510 |
0.326 |
|
| 2017 |
Walsh CT, Tang Y. Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions. Biochemistry. PMID 29236467 DOI: 10.1021/Acs.Biochem.7B01161 |
0.494 |
|
| 2017 |
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Tang Y, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/Nature24006 |
0.626 |
|
| 2017 |
Billingsley JM, DeNicola AB, Barber JS, Tang MC, Horecka J, Chu A, Garg NK, Tang Y. Engineering the Biocatalytic Selectivity of Iridoid Production in Saccharomyces cerevisiae. Metabolic Engineering. PMID 28939278 DOI: 10.1016/J.Ymben.2017.09.006 |
0.406 |
|
| 2017 |
Tang MC, Cui X, He X, Ding Z, Zhu T, Tang Y, Li D. Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products. Organic Letters. PMID 28926261 DOI: 10.1021/acs.orglett.7b02653 |
0.348 |
|
| 2017 |
Ohashi M, Liu F, Hai Y, Chen M, Tang MC, Yang Z, Sato M, Watanabe K, Houk KN, Tang Y. SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. Nature. PMID 28902839 DOI: 10.1038/Nature23882 |
0.482 |
|
| 2017 |
Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng Z, Tang Y, Lin S. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. Journal of the American Chemical Society. PMID 28809552 DOI: 10.1021/Jacs.7B05517 |
0.426 |
|
| 2017 |
Hang L, Tang MC, Harvey CJB, Page CG, Li J, Hung YS, Liu N, Hillenmeyer ME, Tang Y. Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain. Angewandte Chemie (International Ed. in English). PMID 28679030 DOI: 10.1002/Anie.201705237 |
0.364 |
|
| 2017 |
Liu N, Hung YS, Gao SS, Hang L, Zou Y, Chooi YH, Tang Y. Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Organic Letters. PMID 28605916 DOI: 10.1021/acs.orglett.7b01534 |
0.4 |
|
| 2017 |
Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang Y. Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Nature Chemical Biology. PMID 28114276 DOI: 10.1038/Nchembio.2283 |
0.496 |
|
| 2016 |
Hang L, Liu N, Tang Y. Coordinated and Iterative Enzyme Catalysis in Fungal Polyketide Biosynthesis. Acs Catalysis. 6: 5935-5945. PMID 28529817 DOI: 10.1021/acscatal.6b01559 |
0.418 |
|
| 2016 |
Grandner JM, Cacho RA, Tang Y, Houk KN. Mechanism of the P450-Catalyzed Oxidative Cyclization in the Biosynthesis of Griseofulvin. Acs Catalysis. 6: 4506-4511. PMID 28503354 DOI: 10.1021/acscatal.6b01068 |
0.339 |
|
| 2016 |
Pfeifer BA, Tang Y. Editorial overview: Pharmaceutical biotechnology: New approaches for dynamic disease targets. Current Opinion in Biotechnology. PMID 27856096 DOI: 10.1016/J.Copbio.2016.11.002 |
0.551 |
|
| 2016 |
Oikawa H, Tang Y. Exploring the diversification mechanism of skeletal construction in representative natural product families. The Journal of Antibiotics. 69: 471-2. PMID 27460869 DOI: 10.1038/ja.2016.69 |
0.326 |
|
| 2016 |
Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K. Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 27072782 DOI: 10.1002/Anie.201600940 |
0.466 |
|
| 2016 |
Billingsley JM, DeNicola AB, Tang Y. Technology development for natural product biosynthesis in Saccharomyces cerevisiae. Current Opinion in Biotechnology. 42: 74-83. PMID 26994377 DOI: 10.1016/j.copbio.2016.02.033 |
0.373 |
|
| 2016 |
Lin HC, McMahon TC, Patel A, Corsello M, Simon A, Xu W, Zhao M, Houk KN, Garg NK, Tang Y. P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers. Journal of the American Chemical Society. PMID 26963294 DOI: 10.1021/Jacs.6B01413 |
0.375 |
|
| 2016 |
Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Y, Watanabe K. Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis. Organic Letters. PMID 26959241 DOI: 10.1021/Acs.Orglett.6B00380 |
0.502 |
|
| 2016 |
Bond C, Tang Y, Li L. Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genetics and Biology : Fg & B. PMID 26850128 DOI: 10.1016/j.fgb.2016.01.005 |
0.398 |
|
| 2016 |
Cacho RA, Tang Y. Reconstitution of Fungal Nonribosomal Peptide Synthetases in Yeast and In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1401: 103-19. PMID 26831704 DOI: 10.1007/978-1-4939-3375-4_7 |
0.365 |
|
| 2016 |
Cochrane RV, Sanichar R, Lambkin GR, Reiz B, Xu W, Tang Y, Vederas JC. Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent. Angewandte Chemie (International Ed. in English). 55: 664-8. PMID 26783060 DOI: 10.1002/Anie.201509345 |
0.389 |
|
| 2016 |
Meng Y, Cao J, Tang Y, Lu X, Liu L. Synthesis and Anti-tumor Activity of Derivatives of Ring A of Ursolic Acid Chinese Journal of Organic Chemistry. 36: 1080. DOI: 10.6023/cjoc201510034 |
0.309 |
|
| 2016 |
Xu W, Raetz LB, Wang P, Tang Y. An ATP-dependent ligase catalyzes the fourth ring cyclization in tetracycline biosynthesis Tetrahedron. 72: 3599-3604. DOI: 10.1016/j.tet.2015.09.029 |
0.327 |
|
| 2015 |
Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN. Origins of stereoselectivity in evolved ketoreductases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644568 DOI: 10.1073/Pnas.1507910112 |
0.385 |
|
| 2015 |
Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. Journal of the American Chemical Society. PMID 26630357 DOI: 10.1021/Jacs.5B11814 |
0.372 |
|
| 2015 |
Guo YY, Li H, Zhou ZX, Mao XM, Tang Y, Chen X, Jiang XH, Liu Y, Jiang H, Li YQ. Identification and Biosynthetic Characterization of Natural Aromatic Azoxy Products from Streptomyces chattanoogensis L10. Organic Letters. PMID 26623715 DOI: 10.1021/acs.orglett.5b03137 |
0.359 |
|
| 2015 |
Liu J, Peng Y, Wang X, Fan Y, Qin C, Shi L, Tang Y, Li H, Long J, Liu J. Mitochondrial dysfunction launches dexamethasone-induced skeletal muscle atrophy via AMPK/FOXO3 signaling. Molecular Pharmaceutics. PMID 26592738 DOI: 10.1021/acs.molpharmaceut.5b00516 |
0.325 |
|
| 2015 |
Wang Y, Chen CL, Pan QZ, Wu YY, Zhao JJ, Jiang SS, Chao J, Zhang XF, Zhang HX, Zhou ZQ, Tang Y, Huang XQ, Zhang JH, Xia JC. Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma. Oncotarget. PMID 26575170 DOI: 10.18632/oncotarget.6319 |
0.358 |
|
| 2015 |
Jiang SS, Tang Y, Zhang YJ, Weng DS, Zhou ZG, Pan K, Pan QZ, Wang QJ, Liu Q, He J, Zhao JJ, Li J, Chen MS, Chang AE, Li Q, et al. A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma. Oncotarget. PMID 26515587 DOI: 10.18632/oncotarget.5463 |
0.357 |
|
| 2015 |
Cochrane RV, Gao Z, Lambkin GR, Xu W, Winter JM, Marcus SL, Tang Y, Vederas JC. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem : a European Journal of Chemical Biology. PMID 26493380 DOI: 10.1002/Cbic.201500428 |
0.428 |
|
| 2015 |
Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L. Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent. Plos One. 10: e0139013. PMID 26488398 DOI: 10.1371/Journal.Pone.0139013 |
0.405 |
|
| 2015 |
Tang MC, Lin HC, Li D, Zou Y, Li J, Xu W, Cacho RA, Hillenmeyer ME, Garg NK, Tang Y. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. Journal of the American Chemical Society. PMID 26469304 DOI: 10.1021/Jacs.5B06108 |
0.407 |
|
| 2015 |
Liu N, Guo Y, Yang X, Lin H, Yang L, Shi Z, Zhong Z, Wang S, Tang Y, Gao Q. Microwave-Assisted Reactant-Protecting Strategy towards Efficient MoS2 Electrocatalysts in Hydrogen Evolution Reaction. Acs Applied Materials & Interfaces. PMID 26447801 DOI: 10.1021/acsami.5b08103 |
0.321 |
|
| 2015 |
Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/Cbic.201500386 |
0.461 |
|
| 2015 |
Mao XM, Xu W, Li D, Yin WB, Chooi YH, Li YQ, Tang Y, Hu Y. Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products. Angewandte Chemie (International Ed. in English). 54: 7592-6. PMID 26013262 DOI: 10.1002/Anie.201502452 |
0.393 |
|
| 2015 |
Zou Y, Zhan Z, Li D, Tang M, Cacho RA, Watanabe K, Tang Y. Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids. Journal of the American Chemical Society. 137: 4980-3. PMID 25859931 DOI: 10.1021/Jacs.5B03022 |
0.48 |
|
| 2015 |
Mao XM, Luo S, Zhou RC, Wang F, Yu P, Sun N, Chen XX, Tang Y, Li YQ. Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator, AtrA. The Journal of Biological Chemistry. 290: 7992-8001. PMID 25648897 DOI: 10.1074/jbc.M114.608273 |
0.34 |
|
| 2015 |
Soliman S, Tang Y. Natural and engineered production of taxadiene with taxadiene synthase. Biotechnology and Bioengineering. 112: 229-35. PMID 25257933 DOI: 10.1002/Bit.25468 |
0.399 |
|
| 2014 |
Cacho RA, Tang Y, Chooi YH. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Frontiers in Microbiology. 5: 774. PMID 25642215 DOI: 10.3389/Fmicb.2014.00774 |
0.327 |
|
| 2014 |
Zou Y, Xu W, Tsunematsu Y, Tang M, Watanabe K, Tang Y. Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis. Organic Letters. 16: 6390-3. PMID 25494235 DOI: 10.1021/Ol503179V |
0.477 |
|
| 2014 |
Zhao M, Liu Y, Hsieh RS, Wang N, Tai W, Joo KI, Wang P, Gu Z, Tang Y. Clickable protein nanocapsules for targeted delivery of recombinant p53 protein. Journal of the American Chemical Society. 136: 15319-25. PMID 25289975 DOI: 10.1021/Ja508083G |
0.324 |
|
| 2014 |
Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/J.Chembiol.2014.09.001 |
0.656 |
|
| 2014 |
Tsunematsu Y, Fukutomi M, Saruwatari T, Noguchi H, Hotta K, Tang Y, Watanabe K. Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity. Angewandte Chemie (International Ed. in English). 53: 8475-9. PMID 24939566 DOI: 10.1002/Anie.201404804 |
0.522 |
|
| 2014 |
Zabala AO, Chooi YH, Choi MS, Lin HC, Tang Y. Fungal polyketide synthase product chain-length control by partnering thiohydrolase. Acs Chemical Biology. 9: 1576-86. PMID 24845309 DOI: 10.1021/Cb500284T |
0.437 |
|
| 2014 |
Hu Y, Dietrich D, Xu W, Patel A, Thuss JA, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC, Tang Y. A carbonate-forming Baeyer-Villiger monooxygenase. Nature Chemical Biology. 10: 552-4. PMID 24838010 DOI: 10.1038/Nchembio.1527 |
0.314 |
|
| 2014 |
Jiménez-Osés G, Osuna S, Gao X, Sawaya MR, Gilson L, Collier SJ, Huisman GW, Yeates TO, Tang Y, Houk KN. The role of distant mutations and allosteric regulation on LovD active site dynamics. Nature Chemical Biology. 10: 431-6. PMID 24727900 DOI: 10.1038/Nchembio.1503 |
0.401 |
|
| 2014 |
Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Combinatorial Chemistry & High Throughput Screening. 17: 333-42. PMID 24661212 DOI: 10.2174/1386207317666140323133841 |
0.55 |
|
| 2014 |
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. Journal of the American Chemical Society. 136: 4426-36. PMID 24568283 DOI: 10.1021/Ja500881E |
0.494 |
|
| 2014 |
Mao XM, Ren NN, Sun N, Wang F, Zhou RC, Tang Y, Li YQ. Proteasome involvement in a complex cascade mediating SigT degradation during differentiation of Streptomyces coelicolor. Febs Letters. 588: 608-13. PMID 24440356 DOI: 10.1016/j.febslet.2013.12.029 |
0.359 |
|
| 2014 |
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, et al. Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem. 9: 73-7, 2. PMID 24259468 DOI: 10.1002/Cmdc.201300424 |
0.595 |
|
| 2014 |
Li L, Wang P, Tang Y. C-glycosylation of anhydrotetracycline scaffold with SsfS6 from the SF2575 biosynthetic pathway. The Journal of Antibiotics. 67: 65-70. PMID 24022606 DOI: 10.1038/ja.2013.88 |
0.402 |
|
| 2013 |
Chooi YH, Hong YJ, Cacho RA, Tantillo DJ, Tang Y. A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis. Journal of the American Chemical Society. 135: 16805-8. PMID 24161266 DOI: 10.1021/Ja408966T |
0.392 |
|
| 2013 |
Dhingra S, Lind AL, Lin HC, Tang Y, Rokas A, Calvo AM. The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. Plos One. 8: e77147. PMID 24116213 DOI: 10.1371/Journal.Pone.0077147 |
0.324 |
|
| 2013 |
Liu Y, Ding G, Li Y, Qu J, Ma S, Lv H, Liu Y, Wang W, Dai J, Tang Y, Yu S. Structures and absolute configurations of penicillactones A-C from an endophytic microorganism, Penicillium dangeardii Pitt. Organic Letters. 15: 5206-9. PMID 24093807 DOI: 10.1021/ol4023485 |
0.345 |
|
| 2013 |
Winter JM, Chiou G, Bothwell IR, Xu W, Garg NK, Luo M, Tang Y. Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Organic Letters. 15: 3774-7. PMID 23837609 DOI: 10.1021/Ol401723H |
0.381 |
|
| 2013 |
Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y. Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82. PMID 23659680 DOI: 10.1021/Cb4001684 |
0.345 |
|
| 2013 |
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y. LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angewandte Chemie (International Ed. in English). 52: 6472-5. PMID 23653178 DOI: 10.1002/Anie.201302406 |
0.326 |
|
| 2013 |
Chooi YH, Fang J, Liu H, Filler SG, Wang P, Tang Y. Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Organic Letters. 15: 780-3. PMID 23368997 DOI: 10.1021/Ol303435Y |
0.319 |
|
| 2013 |
Cacho RA, Tang Y. Bringing protein engineering and natural product biosynthesis together. Chemistry & Biology. 20: 3-5. PMID 23352133 DOI: 10.1016/j.chembiol.2013.01.005 |
0.41 |
|
| 2013 |
Haynes SW, Gao X, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. Acs Chemical Biology. 8: 741-8. PMID 23330675 DOI: 10.1021/Cb3006787 |
0.406 |
|
| 2013 |
Xu W, Qiao K, Tang Y. Structural analysis of protein-protein interactions in type I polyketide synthases. Critical Reviews in Biochemistry and Molecular Biology. 48: 98-122. PMID 23249187 DOI: 10.3109/10409238.2012.745476 |
0.406 |
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| 2013 |
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, et al. Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014) Chemmedchem. 9: 2-2. DOI: 10.1002/Cmdc.201390058 |
0.533 |
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| 2012 |
Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... Tang Y, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/Journal.Pone.0050864 |
0.771 |
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| 2012 |
Winter JM, Sato M, Sugimoto S, Chiou G, Garg NK, Tang Y, Watanabe K. Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. Journal of the American Chemical Society. 134: 17900-3. PMID 23072467 DOI: 10.1021/Ja3090498 |
0.453 |
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| 2012 |
Haynes SW, Gao X, Tang Y, Walsh CT. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Journal of the American Chemical Society. 134: 17444-7. PMID 23030663 DOI: 10.1021/Ja308371Z |
0.375 |
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| 2012 |
Wang P, Kim W, Pickens LB, Gao X, Tang Y. Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angewandte Chemie (International Ed. in English). 51: 11136-40. PMID 23024027 DOI: 10.1002/Anie.201205426 |
0.336 |
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| 2012 |
Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Journal of the American Chemical Society. 134: 16781-90. PMID 22998630 DOI: 10.1021/Ja307220Z |
0.357 |
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| 2012 |
Chooi YH, Tang Y. Navigating the fungal polyketide chemical space: from genes to molecules. The Journal of Organic Chemistry. 77: 9933-53. PMID 22938194 DOI: 10.1021/Jo301592K |
0.401 |
|
| 2012 |
Zabala AO, Xu W, Chooi YH, Tang Y. Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chemistry & Biology. 19: 1049-59. PMID 22921072 DOI: 10.1016/J.Chembiol.2012.07.004 |
0.357 |
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| 2012 |
Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30. PMID 22902615 DOI: 10.1038/Nchembio.1047 |
0.355 |
|
| 2012 |
Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/Pnas.1113029109 |
0.422 |
|
| 2012 |
Chooi YH, Wang P, Fang J, Li Y, Wu K, Wang P, Tang Y. Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. Journal of the American Chemical Society. 134: 9428-37. PMID 22590971 DOI: 10.1021/Ja3028636 |
0.391 |
|
| 2012 |
Wang P, Gao X, Tang Y. Complexity generation during natural product biosynthesis using redox enzymes. Current Opinion in Chemical Biology. 16: 362-9. PMID 22564679 DOI: 10.1016/J.Cbpa.2012.04.008 |
0.405 |
|
| 2012 |
Zhou H, Gao Z, Qiao K, Wang J, Vederas JC, Tang Y. A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology. 8: 331-3. PMID 22406519 DOI: 10.1038/Nchembio.912 |
0.38 |
|
| 2012 |
Liu Q, Yao F, Chooi YH, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D. Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation. Chemistry & Biology. 19: 243-53. PMID 22365607 DOI: 10.1016/J.Chembiol.2011.12.018 |
0.378 |
|
| 2012 |
Winter JM, Tang Y. Synthetic biological approaches to natural product biosynthesis Current Opinion in Biotechnology. 23: 736-743. PMID 22221832 DOI: 10.1016/j.copbio.2011.12.016 |
0.407 |
|
| 2012 |
Zabala AO, Cacho RA, Tang Y. Protein engineering towards natural product synthesis and diversification. Journal of Industrial Microbiology & Biotechnology. 39: 227-41. PMID 22006344 DOI: 10.1007/S10295-011-1044-2 |
0.421 |
|
| 2012 |
Smanski MJ, Qu XD, Liu W, Shen B, Tang Y, Yu Y, Deng ZX. Biosynthesis of Pharmaceutical Natural Products and Their Pathway Engineering Organic Chemistry - Breakthroughs and Perspectives. 125-180. DOI: 10.1002/9783527664801.ch4 |
0.343 |
|
| 2011 |
Pickens LB, Tang Y, Chooi YH. Metabolic engineering for the production of natural products. Annual Review of Chemical and Biomolecular Engineering. 2: 211-36. PMID 22432617 DOI: 10.1146/Annurev-Chembioeng-061010-114209 |
0.378 |
|
| 2011 |
Qiao K, Chooi YH, Tang Y. Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metabolic Engineering. 13: 723-32. PMID 21983160 DOI: 10.1016/J.Ymben.2011.09.008 |
0.349 |
|
| 2011 |
Pickens LB, Sawaya MR, Rasool H, Pashkov I, Yeates TO, Tang Y. Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway. The Journal of Biological Chemistry. 286: 41539-51. PMID 21965680 DOI: 10.1074/Jbc.M111.299859 |
0.41 |
|
| 2011 |
Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/Bi201302W |
0.393 |
|
| 2011 |
Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 50: 8392-406. PMID 21870821 DOI: 10.1021/Bi200593M |
0.383 |
|
| 2011 |
Li Y, Chooi YH, Sheng Y, Valentine JS, Tang Y. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. Journal of the American Chemical Society. 133: 15773-85. PMID 21866960 DOI: 10.1021/Ja206906D |
0.413 |
|
| 2011 |
Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/Jbc.M111.247627 |
0.681 |
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| 2011 |
Wang P, Gao X, Chooi YH, Deng Z, Tang Y. Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in Streptomyces rimosus. Microbiology (Reading, England). 157: 2401-9. PMID 21622525 DOI: 10.1099/Mic.0.048439-0 |
0.401 |
|
| 2011 |
Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79. PMID 21591693 DOI: 10.1021/Bi2004922 |
0.359 |
|
| 2011 |
Qiao K, Zhou H, Xu W, Zhang W, Garg N, Tang Y. A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. Organic Letters. 13: 1758-61. PMID 21384820 DOI: 10.1021/Ol200288W |
0.356 |
|
| 2011 |
Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/Ja1101085 |
0.409 |
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| 2011 |
Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein PC. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. Biochemistry. 50: 287-99. PMID 21069965 DOI: 10.1021/Bi1014776 |
0.366 |
|
| 2010 |
Zhou H, Qiao K, Gao Z, Vederas JC, Tang Y. Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. The Journal of Biological Chemistry. 285: 41412-21. PMID 20961859 DOI: 10.1074/Jbc.M110.183574 |
0.404 |
|
| 2010 |
Gao X, Wang P, Tang Y. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Applied Microbiology and Biotechnology. 88: 1233-42. PMID 20853106 DOI: 10.1007/S00253-010-2860-4 |
0.366 |
|
| 2010 |
Xu W, Cai X, Jung ME, Tang Y. Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. Journal of the American Chemical Society. 132: 13604-7. PMID 20828130 DOI: 10.1021/Ja107084D |
0.42 |
|
| 2010 |
Chooi YH, Tang Y. Adding the lipo to lipopeptides: do more with less. Chemistry & Biology. 17: 791-3. PMID 20797606 DOI: 10.1016/j.chembiol.2010.08.001 |
0.311 |
|
| 2010 |
Chooi YH, Cacho R, Tang Y. Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chemistry & Biology. 17: 483-94. PMID 20534346 DOI: 10.1016/J.Chembiol.2010.03.015 |
0.345 |
|
| 2010 |
Pickens LB, Tang Y. Oxytetracycline biosynthesis. The Journal of Biological Chemistry. 285: 27509-15. PMID 20522541 DOI: 10.1074/jbc.R110.130419 |
0.407 |
|
| 2010 |
Li Y, Image II, Xu W, Image I, Tang Y, Image I. Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. The Journal of Biological Chemistry. 285: 22764-73. PMID 20479000 DOI: 10.1074/Jbc.M110.128504 |
0.336 |
|
| 2010 |
Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society. 132: 4530-1. PMID 20222707 DOI: 10.1021/Ja100060K |
0.415 |
|
| 2010 |
Zhou H, Li Y, Tang Y. ChemInform Abstract: Cyclization of Aromatic Polyketides from Bacteria and Fungi Cheminform. 41: no-no. DOI: 10.1002/chin.201037270 |
0.312 |
|
| 2009 |
Pickens LB, Kim W, Wang P, Zhou H, Watanabe K, Gomi S, Tang Y. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. Journal of the American Chemical Society. 131: 17677-89. PMID 19908837 DOI: 10.1021/Ja907852C |
0.499 |
|
| 2009 |
Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y. Directed evolution and structural characterization of a simvastatin synthase. Chemistry & Biology. 16: 1064-74. PMID 19875080 DOI: 10.1016/J.Chembiol.2009.09.017 |
0.372 |
|
| 2009 |
Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA. Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase. Chembiochem : a European Journal of Chemical Biology. 10: 2188-90. PMID 19670197 DOI: 10.1002/Cbic.200900407 |
0.344 |
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| 2009 |
Wang M, Zhou H, Wirz M, Tang Y, Boddy CN. A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. Biochemistry. 48: 6288-90. PMID 19530704 DOI: 10.1021/Bi9009049 |
0.647 |
|
| 2009 |
Wang P, Zhang W, Zhan J, Tang Y. Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1544-50. PMID 19472250 DOI: 10.1002/Cbic.200900122 |
0.399 |
|
| 2009 |
Zhan J, Qiao K, Tang Y. Investigation of tailoring modifications in pradimicin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1447-52. PMID 19431159 DOI: 10.1002/Cbic.200900082 |
0.324 |
|
| 2009 |
Pickens LB, Tang Y. Decoding and engineering tetracycline biosynthesis. Metabolic Engineering. 11: 69-75. PMID 19007902 DOI: 10.1016/J.Ymben.2008.10.001 |
0.347 |
|
| 2009 |
Xie X, Pashkov I, Gao X, Guerrero JL, Yeates TO, Tang Y. Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity. Biotechnology and Bioengineering. 102: 20-8. PMID 18988191 DOI: 10.1002/Bit.22028 |
0.386 |
|
| 2009 |
Cheng Z, Tang Y, Chen Y, Kim S, Liu H, Li SS, Gu W, Zhao Y. Molecular characterization of propionyllysines in non-histone proteins. Molecular & Cellular Proteomics : McP. 8: 45-52. PMID 18753126 DOI: 10.1074/Mcp.M800224-Mcp200 |
0.361 |
|
| 2008 |
Zhang W, Li Y, Tang Y. Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 105: 20683-8. PMID 19075227 DOI: 10.1073/Pnas.0809084105 |
0.405 |
|
| 2008 |
Zhou H, Xie X, Tang Y. Engineering natural products using combinatorial biosynthesis and biocatalysis. Current Opinion in Biotechnology. 19: 590-6. PMID 18992814 DOI: 10.1016/J.Copbio.2008.10.012 |
0.418 |
|
| 2008 |
Zhan J, Watanabe K, Tang Y. Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1710-5. PMID 18604835 DOI: 10.1002/Cbic.200800178 |
0.414 |
|
| 2008 |
Zhou H, Zhan J, Watanabe K, Xie X, Tang Y. A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences of the United States of America. 105: 6249-54. PMID 18427109 DOI: 10.1073/Pnas.0800657105 |
0.506 |
|
| 2008 |
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. Journal of the American Chemical Society. 130: 6068-9. PMID 18422316 DOI: 10.1021/Ja800951E |
0.509 |
|
| 2008 |
Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/J.Bmcl.2008.01.073 |
0.535 |
|
| 2008 |
Zhang W, Tang Y. ChemInform Abstract: Combinatorial Biosynthesis of Natural Products Cheminform. 39. DOI: 10.1002/chin.200830264 |
0.329 |
|
| 2007 |
Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/J.Chembiol.2007.07.012 |
0.528 |
|
| 2007 |
Zhang W, Watanabe K, Wang CC, Tang Y. Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. The Journal of Biological Chemistry. 282: 25717-25. PMID 17631493 DOI: 10.1074/Jbc.M703437200 |
0.6 |
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| 2007 |
Xie X, Wong WW, Tang Y. Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metabolic Engineering. 9: 379-86. PMID 17625941 DOI: 10.1016/J.Ymben.2007.05.006 |
0.371 |
|
| 2007 |
Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y. A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society. 129: 9304-5. PMID 17625867 DOI: 10.1021/Ja0736919 |
0.696 |
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| 2007 |
Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/Annurev.Biochem.76.053105.093515 |
0.785 |
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| 2007 |
Xie X, Tang Y. Efficient synthesis of simvastatin by use of whole-cell biocatalysis. Applied and Environmental Microbiology. 73: 2054-60. PMID 17277201 DOI: 10.1128/AEM.02820-06 |
0.341 |
|
| 2007 |
Chen Y, Sprung R, Tang Y, Ball H, Sangras B, Kim SC, Falck JR, Peng J, Gu W, Zhao Y. Lysine propionylation and butyrylation are novel post-translational modifications in histones. Molecular & Cellular Proteomics : McP. 6: 812-9. PMID 17267393 DOI: 10.1074/Mcp.M700021-Mcp200 |
0.359 |
|
| 2006 |
Zhang W, Watanabe K, Wang CC, Tang Y. Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase. Journal of Natural Products. 69: 1633-6. PMID 17125237 DOI: 10.1021/Np060290I |
0.577 |
|
| 2006 |
Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/Bi061187V |
0.619 |
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| 2006 |
Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chemistry & Biology. 13: 1161-9. PMID 17113998 DOI: 10.1016/J.Chembiol.2006.09.008 |
0.597 |
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| 2006 |
Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/Pnas.0601924103 |
0.535 |
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| 2006 |
Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/J.Chembiol.2006.04.008 |
0.702 |
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| 2005 |
Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/Ja.2005.91 |
0.629 |
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| 2005 |
Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/Ja051429Z |
0.649 |
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| 2005 |
Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/Science.1111415 |
0.501 |
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| 2004 |
Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/Bi048418N |
0.773 |
|
| 2004 |
Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6 |
0.609 |
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| 2004 |
Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/Bi049157K |
0.555 |
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| 2004 |
Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/Journal.Pbio.0020031 |
0.656 |
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| 2004 |
Tang Y, Lee TS, Lee HY, Khosla C. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases Tetrahedron. 60: 7659-7671. DOI: 10.1016/J.Tet.2004.05.118 |
0.653 |
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| 2003 |
Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/Ja0378759 |
0.529 |
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| 2003 |
Cirino PC, Tang Y, Takahashi K, Tirrell DA, Arnold FH. Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering. 83: 729-34. PMID 12889037 DOI: 10.1002/Bit.10718 |
0.397 |
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| 2003 |
Wang P, Tang Y, Tirrell DA. Incorporation of trifluoroisoleucine into proteins in vivo. Journal of the American Chemical Society. 125: 6900-6. PMID 12783542 DOI: 10.1021/Ja0298287 |
0.362 |
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| 2003 |
Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/Bi0341962 |
0.665 |
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| 2002 |
Tang Y, Tirrell DA. Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivo. Biochemistry. 41: 10635-45. PMID 12186549 DOI: 10.1021/Bi026130X |
0.355 |
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| 1997 |
XU J, TANG Y, ZHANG H, GAO Z. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 27: 303-317. DOI: 10.1023/A:1007962502627 |
0.306 |
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