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Brent A. Appleton, Ph.D. - Publications

Affiliations: 
2004 Harvard University, Cambridge, MA, United States 
Area:
structural biology
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gomez L, Xu R, Sinko W, Selfridge B, Vernier WF, Ly K, Truong R, Metz M, Marrone T, Sebring K, Yan Y, Appleton B, Aertgeerts K, Massari E, Breitenbucher JG. Mathematical and Structural Characterization of Strong Non-additive SAR Caused by Protein Conformational Changes. Journal of Medicinal Chemistry. PMID 30070482 DOI: 10.1021/acs.jmedchem.8b00713  0.343
2014 Gazzard L, Appleton B, Chapman K, Chen H, Clark K, Drobnick J, Goodacre S, Halladay J, Lyssikatos J, Schmidt S, Sideris S, Wiesmann C, Williams K, Wu P, Yen I, et al. Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1. Bioorganic & Medicinal Chemistry Letters. 24: 5704-9. PMID 25453805 DOI: 10.1016/J.Bmcl.2014.10.063  0.356
2014 Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS. A structural portrait of the PDZ domain family. Journal of Molecular Biology. 426: 3509-19. PMID 25158098 DOI: 10.1016/J.Jmb.2014.08.012  0.535
2009 Bostrom J, Yu SF, Kan D, Appleton BA, Lee CV, Billeci K, Man W, Peale F, Ross S, Wiesmann C, Fuh G. Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science (New York, N.Y.). 323: 1610-4. PMID 19299620 DOI: 10.1126/Science.1165480  0.314
2009 Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS. Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chemical Biology. 5: 217-9. PMID 19252499 DOI: 10.1038/Nchembio.152  0.419
2008 Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, et al. A specificity map for the PDZ domain family. Plos Biology. 6: e239. PMID 18828675 DOI: 10.1371/Journal.Pbio.0060239  0.5
2008 Barthelemy PA, Raab H, Appleton BA, Bond CJ, Wu P, Wiesmann C, Sidhu SS. Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. The Journal of Biological Chemistry. 283: 3639-54. PMID 18045863 DOI: 10.1074/Jbc.M708536200  0.361
2007 Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, Mortara K, Bowman KK, Elliott JM, Desmarais W, Bazan JF, Bagri A, Tessier-Lavigne M, Koch AW, Wu Y, et al. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. The Embo Journal. 26: 4902-12. PMID 17989695 DOI: 10.1038/Sj.Emboj.7601906  0.426
2007 Runyon ST, Zhang Y, Appleton BA, Sazinsky SL, Wu P, Pan B, Wiesmann C, Skelton NJ, Sidhu SS. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. Protein Science : a Publication of the Protein Society. 16: 2454-71. PMID 17962403 DOI: 10.1110/Ps.073049407  0.532
2007 Zhang Y, Appleton BA, Wu P, Wiesmann C, Sidhu SS. Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain. Protein Science : a Publication of the Protein Society. 16: 1738-50. PMID 17656586 DOI: 10.1110/Ps.072833207  0.517
2006 Appleton BA, Zhang Y, Wu P, Yin JP, Hunziker W, Skelton NJ, Sidhu SS, Wiesmann C. Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. The Journal of Biological Chemistry. 281: 22312-20. PMID 16737969 DOI: 10.1074/Jbc.M602901200  0.508
2006 Zhang Y, Yeh S, Appleton BA, Held HA, Kausalya PJ, Phua DC, Wong WL, Lasky LA, Wiesmann C, Hunziker W, Sidhu SS. Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families. The Journal of Biological Chemistry. 281: 22299-311. PMID 16737968 DOI: 10.1074/Jbc.M602902200  0.528
2006 Appleton BA, Wu P, Wiesmann C. The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure (London, England : 1993). 14: 87-96. PMID 16407068 DOI: 10.1016/J.Str.2005.09.013  0.407
2006 Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. The Journal of Biological Chemistry. 281: 5224-32. PMID 16371349 DOI: 10.1074/Jbc.M506900200  0.645
2004 Loregian A, Appleton BA, Hogle JM, Coen DM. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. Journal of Virology. 78: 9084-92. PMID 15308704 DOI: 10.1128/Jvi.78.17.9084-9092.2004  0.647
2004 Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Molecular Cell. 15: 233-44. PMID 15260974 DOI: 10.1016/J.Molcel.2004.06.018  0.623
2004 Loregian A, Appleton BA, Hogle JM, Coen DM. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. Journal of Virology. 78: 158-67. PMID 14671097 DOI: 10.1128/Jvi.78.1.158-167.2004  0.649
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