| Year |
Citation |
Score |
| 2020 |
Dornbos P, Raffield L, Yin X, Flannick J. 241-OR: Causal Gene Candidates for Type 2 Diabetes Based on Protein-Coding Variants in 127,676 Individuals Diabetes. 69. DOI: 10.2337/Db20-241-Or |
0.36 |
|
| 2019 |
Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, ... ... Flannick J, et al. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nature Genetics. PMID 31676859 DOI: 10.1038/S41588-019-0513-9 |
0.326 |
|
| 2019 |
Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. PMID 31118516 DOI: 10.1038/s41586-019-1231-2 |
0.313 |
|
| 2019 |
Flannick J. The Contribution of Low-Frequency and Rare Coding Variation to Susceptibility to Type 2 Diabetes. Current Diabetes Reports. 19: 25. PMID 30957210 DOI: 10.1007/S11892-019-1142-5 |
0.387 |
|
| 2019 |
Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, et al. Discovering metabolic disease gene interactions by correlated effects on cellular morphology. Molecular Metabolism. PMID 30940487 DOI: 10.1016/J.Molmet.2019.03.001 |
0.332 |
|
| 2019 |
CHEN L, SRINIVASAN S, SANTORO N, TODD J, DIVERS J, SHAH AS, GIDDING S, BURKE BK, HAYMOND MW, LANGE L, MARCOVINA SM, CHAIT A, FLANNICK J, CAPRIO S, FLOREZ JC. 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium Diabetes. 68: 177-OR. DOI: 10.2337/Db19-177-Or |
0.363 |
|
| 2019 |
Udler M, Flannick J, Mercader J, Fuchsberger C, Mahajan A. OR05-1 Genetic Discovery and Translational Decision Support from Exome Sequencing of 45,231 Type 2 Diabetes Cases and Controls from Five Ancestries Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Or05-1 |
0.344 |
|
| 2018 |
Udler MS, Kim J, von Grotthuss M, Bonàs-Guarch S, Cole JB, Chiou J, Boehnke M, Laakso M, Atzmon G, Glaser B, Mercader JM, Gaulton K, Flannick J, Getz G, et al. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. Plos Medicine. 15: e1002654. PMID 30240442 DOI: 10.1371/Journal.Pmed.1002654 |
0.354 |
|
| 2018 |
Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, ... ... Flannick J, et al. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications. 9: 2252. PMID 29899519 DOI: 10.1038/S41467-018-04611-Z |
0.351 |
|
| 2018 |
Ganna A, Satterstrom FK, Zekavat SM, Das I, Kurki MI, Churchhouse C, Alfoldi J, Martin AR, Havulinna AS, Byrnes A, Thompson WK, Nielsen PR, Karczewski KJ, Saarentaus E, Rivas MA, ... ... Flannick J, et al. Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. American Journal of Human Genetics. PMID 29861106 DOI: 10.1016/J.Ajhg.2018.05.002 |
0.376 |
|
| 2018 |
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M, Cortes-Sánchez P, González S, Timshel P, Pers TH, Morgan CC, Moran I, Atla G, ... ... Flannick J, et al. Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nature Communications. 9: 2162. PMID 29849136 DOI: 10.1038/S41467-018-04170-3 |
0.302 |
|
| 2018 |
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, ... ... Flannick J, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics. 50: 559-571. PMID 29632382 DOI: 10.1038/S41588-018-0084-1 |
0.378 |
|
| 2018 |
Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, Wang TJ, Flannick J, Dupuis J, Levy D, Gerszten RE, Florez JC, Meigs JB. Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose. Diabetologia. PMID 29626220 DOI: 10.1007/S00125-018-4599-X |
0.31 |
|
| 2018 |
Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M, Myers CL, et al. Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. Cell. PMID 29526462 DOI: 10.1016/J.Cell.2018.02.026 |
0.329 |
|
| 2018 |
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M, Cortes-Sánchez P, González S, Timshel P, Pers TH, Morgan CC, Moran I, Atla G, ... ... Flannick J, et al. Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nature Communications. 9: 321. PMID 29358691 DOI: 10.1038/S41467-017-02380-9 |
0.411 |
|
| 2018 |
Crawford KM, Gallego-Fabrega C, Kourkoulis C, Miyares L, Marini S, Flannick J, Burtt NP, von Grotthuss M, Alexander B, Costanzo MC, Vaishnav NH, Malik R, Hall JL, Chong M, Rosand J, et al. Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke. Stroke. PMID 29335331 DOI: 10.1161/Strokeaha.117.018922 |
0.335 |
|
| 2018 |
TODD J, KLEINBERGER JW, SRINIVASAN S, TOLLEFSEN SE, LEVITSKY LL, KATZ LE, TRYGGESTAD JB, BACHA F, IMPERATORE G, LAWRENCE JM, PIHOKER C, DIVERS J, FLANNICK J, DABELEA D, FLOREZ JC, et al. Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration Diabetes. 67: 268-OR. DOI: 10.2337/Db18-268-Or |
0.344 |
|
| 2017 |
Noh HJ, Tang R, Flannick J, O'Dushlaine C, Swofford R, Howrigan D, Genereux DP, Johnson J, van Grootheest G, Grünblatt E, Andersson E, Djurfeldt DR, Patel PD, Koltookian M, M Hultman C, et al. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nature Communications. 8: 774. PMID 29042551 DOI: 10.1038/S41467-017-00831-X |
0.336 |
|
| 2017 |
Mercader JM, Liao RG, Davis A, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macías H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordoñez-Sánchez ML, ... ... Flannick J, et al. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes. Diabetes. PMID 28838971 DOI: 10.2337/Db17-0187 |
0.383 |
|
| 2017 |
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, ... Flannick J, et al. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. PMID 28341696 DOI: 10.2337/Db16-1329 |
0.387 |
|
| 2016 |
Najmi LA, Aukrust I, Flannick J, Molnes J, Burtt N, Molven A, Groop L, Altshuler D, Johansson S, Bjørkhaug L, Njølstad PR. Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population. Diabetes. PMID 27899486 DOI: 10.2337/Db16-0460 |
0.377 |
|
| 2016 |
Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, ... ... Flannick J, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 536: 285-291. PMID 27535533 DOI: 10.1038/Nature19057 |
0.387 |
|
| 2016 |
Flannick J, Florez JC. Type 2 diabetes: genetic data sharing to advance complex disease research. Nature Reviews. Genetics. PMID 27402621 DOI: 10.1038/Nrg.2016.56 |
0.408 |
|
| 2016 |
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, et al. The genetic architecture of type 2 diabetes. Nature. PMID 27398621 DOI: 10.1038/Nature18642 |
0.325 |
|
| 2016 |
Flannick J, Johansson S, Njølstad PR. Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nature Reviews. Endocrinology. PMID 27080136 DOI: 10.1038/Nrendo.2016.50 |
0.346 |
|
| 2016 |
Clapham KR, Chu AY, Wessel J, Natarajan P, Flannick J, Rivas MA, Sartori S, Mehran R, Baber U, Fuster V, Scott RA, Rader DJ, Boehnke M, McCarthy MI, Altshuler DM, et al. A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. Bmc Endocrine Disorders. 16: 7. PMID 26822414 DOI: 10.1186/S12902-016-0088-8 |
0.311 |
|
| 2016 |
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, ... ... Flannick J, et al. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications. 7: 10531. PMID 26818947 DOI: 10.1038/Ncomms10531 |
0.341 |
|
| 2015 |
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, ... ... Flannick J, et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics. PMID 26551672 DOI: 10.1038/Ng.3437 |
0.378 |
|
| 2015 |
Moutsianas L, Agarwala V, Fuchsberger C, Flannick J, Rivas MA, Gaulton KJ, Albers PK, McVean G, Boehnke M, Altshuler D, McCarthy MI. The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease. Plos Genetics. 11: e1005165. PMID 25906071 DOI: 10.1371/Journal.Pgen.1005165 |
0.362 |
|
| 2015 |
Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N, Im HK, Cingolani P, Flannick J, Fontanillas P, Fuchsberger C, Gaulton KJ, Teslovich TM, et al. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. Plos Genetics. 11: e1004876. PMID 25625282 DOI: 10.1371/Journal.Pgen.1004876 |
0.399 |
|
| 2015 |
Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, ... Flannick J, et al. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Science Translational Medicine. 7: 270ra6. PMID 25589632 DOI: 10.1126/Scitranslmed.3010134 |
0.335 |
|
| 2014 |
Lim ET, Liu YP, Chan Y, Tiinamaija T, Käräjämäki A, Madsen E, Altshuler DM, Raychaudhuri S, Groop L, Flannick J, Hirschhorn JN, Katsanis N, Daly MJ. A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity. American Journal of Human Genetics. 95: 509-20. PMID 25439097 DOI: 10.1016/J.Ajhg.2014.09.015 |
0.38 |
|
| 2014 |
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Rosen ED, Altshuler D. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 111: 13127-32. PMID 25157153 DOI: 10.1073/Pnas.1410428111 |
0.389 |
|
| 2014 |
Lim ET, Würtz P, Havulinna AS, Palta P, Tukiainen T, Rehnström K, Esko T, Mägi R, Inouye M, Lappalainen T, Chan Y, Salem RM, Lek M, Flannick J, Sim X, et al. Distribution and medical impact of loss-of-function variants in the Finnish founder population. Plos Genetics. 10: e1004494. PMID 25078778 DOI: 10.1371/Journal.Pgen.1004494 |
0.386 |
|
| 2014 |
Estrada K, Aukrust I, Bjørkhaug L, Burtt NP, Mercader JM, García-Ortiz H, Huerta-Chagoya A, Moreno-Macías H, Walford G, Flannick J, Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. Jama. 311: 2305-14. PMID 24915262 DOI: 10.1001/Jama.2014.6511 |
0.316 |
|
| 2014 |
Wang SR, Agarwala V, Flannick J, Chiang CW, Altshuler D, Hirschhorn JN. Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland. American Journal of Human Genetics. 94: 710-20. PMID 24768551 DOI: 10.1016/J.Ajhg.2014.03.019 |
0.377 |
|
| 2014 |
Flannick J, Thorleifsson G, Beer NL, Jacobs SB, Grarup N, Burtt NP, Mahajan A, Fuchsberger C, Atzmon G, Benediktsson R, Blangero J, Bowden DW, Brandslund I, Brosnan J, Burslem F, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nature Genetics. 46: 357-63. PMID 24584071 DOI: 10.1038/Ng.2915 |
0.386 |
|
| 2014 |
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, ... Flannick J, et al. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics. 94: 233-45. PMID 24507775 DOI: 10.1016/J.Ajhg.2014.01.010 |
0.356 |
|
| 2014 |
Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, et al. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circulation Research. 114: 845-50. PMID 24379297 DOI: 10.1161/Circresaha.114.302347 |
0.302 |
|
| 2014 |
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman P, Mar BG, Lindsley RC, Mermel C, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kinnunen L, Koistinen H, Ladenvall C, et al. Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes Blood. 124: 840-840. DOI: 10.1182/Blood.V124.21.840.840 |
0.347 |
|
| 2014 |
Gaulton K, Flannick J, Fuchsberger C. Whole genome and exome sequencing of type 2 diabetes Frontiers in Diabetes. 23: 29-41. DOI: 10.1159/000362465 |
0.314 |
|
| 2013 |
Agarwala V, Flannick J, Sunyaev S, Altshuler D. Evaluating empirical bounds on complex disease genetic architecture. Nature Genetics. 45: 1418-27. PMID 24141362 DOI: 10.1038/Ng.2804 |
0.389 |
|
| 2013 |
Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, et al. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nature Genetics. 45: 1380-5. PMID 24097065 DOI: 10.1038/Ng.2794 |
0.411 |
|
| 2013 |
Lim ET, Raychaudhuri S, Sanders SJ, Stevens C, Sabo A, MacArthur DG, Neale BM, Kirby A, Ruderfer DM, Fromer M, Lek M, Liu L, Flannick J, Ripke S, Nagaswamy U, et al. Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron. 77: 235-42. PMID 23352160 DOI: 10.1016/J.Neuron.2012.12.029 |
0.311 |
|
| 2013 |
Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. American Journal of Human Genetics. 92: 15-27. PMID 23261300 DOI: 10.1016/J.Ajhg.2012.11.012 |
0.323 |
|
| 2012 |
Bick AG, Flannick J, Ito K, Cheng S, Vasan RS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J, Taylor HA, et al. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. American Journal of Human Genetics. 91: 513-9. PMID 22958901 DOI: 10.1016/J.Ajhg.2012.07.017 |
0.355 |
|
| 2012 |
Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, ... ... Flannick J, et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature. 485: 242-5. PMID 22495311 DOI: 10.1038/Nature11011 |
0.347 |
|
| 2009 |
Flannick J, Novak A, Do CB, Srinivasan BS, Batzoglou S. Automatic parameter learning for multiple local network alignment. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 16: 1001-22. PMID 19645599 DOI: 10.1089/Cmb.2009.0099 |
0.603 |
|
| 2008 |
Boutte CC, Srinivasan BS, Flannick JA, Novak AF, Martens AT, Batzoglou S, Viollier PH, Crosson S. Genetic and computational identification of a conserved bacterial metabolic module. Plos Genetics. 4: e1000310. PMID 19096521 DOI: 10.1371/Journal.Pgen.1000310 |
0.566 |
|
| 2008 |
Flannick J, Novak A, Do CB, Srinivasan BS, Batzoglou S. Automatic parameter learning for multiple network alignment Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 4955: 214-231. DOI: 10.1007/978-3-540-78839-3_19 |
0.527 |
|
| 2007 |
Srinivasan BS, Shah NH, Flannick JA, Abeliuk E, Novak AF, Batzoglou S. Current progress in network research: toward reference networks for key model organisms. Briefings in Bioinformatics. 8: 318-32. PMID 17728341 DOI: 10.1093/Bib/Bbm038 |
0.567 |
|
| 2006 |
Flannick J, Novak A, Srinivasan BS, McAdams HH, Batzoglou S. Graemlin: general and robust alignment of multiple large interaction networks. Genome Research. 16: 1169-81. PMID 16899655 DOI: 10.1101/Gr.5235706 |
0.605 |
|
| 2006 |
Srinivasan BS, Novak AF, Flannick JA, Batzoglou S, McAdams HH. Integrated protein interaction networks for 11 microbes Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 3909: 1-14. |
0.546 |
|
| 2005 |
Flannick J, Batzoglou S. Using multiple alignments to improve seeded local alignment algorithms. Nucleic Acids Research. 33: 4563-77. PMID 16100379 DOI: 10.1093/Nar/Gki767 |
0.553 |
|
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