| Year |
Citation |
Score |
| 2023 |
Hagenah LM, Dhingra SK, Small-Saunders JL, Qahash T, Willems A, Schindler KA, Rangel GW, Gil-Iturbe E, Kim J, Akhundova E, Yeo T, Okombo J, Mancia F, Quick M, Roepe PD, et al. Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered physiology. Mbio. e0183223. PMID 38059639 DOI: 10.1128/mbio.01832-23 |
0.411 |
|
| 2022 |
Small-Saunders JL, Hagenah LM, Wicht KJ, Dhingra SK, Deni I, Kim J, Vendome J, Gil-Iturbe E, Roepe PD, Mehta M, Mancia F, Quick M, Eppstein MJ, Fidock DA. Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. Plos Pathogens. 18: e1010278. PMID 35130315 DOI: 10.1371/journal.ppat.1010278 |
0.427 |
|
| 2021 |
Hassett MR, Roepe PD. In vitro growth competition experiments that suggest consequences of the substandard artemisinin epidemic that may be accelerating drug resistance in P. falciparum malaria. Plos One. 16: e0248057. PMID 33690638 DOI: 10.1371/journal.pone.0248057 |
0.397 |
|
| 2021 |
Ribbiso KA, Heller LE, Taye A, Julian E, Willems AV, Roepe PD. Artemisinin - Based Drugs Target the heme-detoxification pathway. Antimicrobial Agents and Chemotherapy. PMID 33495226 DOI: 10.1128/AAC.02137-20 |
0.359 |
|
| 2020 |
Krishnan K, Ziniel P, Li H, Huang X, Hupalo D, Gombakomba N, Guerrero SM, Dotrang T, Lu X, Caridha D, Sternberg AR, Hughes E, Sun W, Bargieri DY, Roepe PD, et al. Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of Phosphatidylinositol 4-Kinase ( PI4KIIIβ). Acs Pharmacology & Translational Science. 3: 948-964. PMID 33073193 DOI: 10.1021/acsptsci.0c00078 |
0.349 |
|
| 2020 |
Riegel B, Roepe PD. Altered Drug Transport by Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance. Biochemistry. PMID 32589406 DOI: 10.1021/Acs.Biochem.0C00247 |
0.511 |
|
| 2019 |
Heller L, Roepe PD, de Dios AC. Artesunate Activation by Heme in an Aqueous Medium. Inorganica Chimica Acta. 496. PMID 32831389 DOI: 10.1016/J.Ica.2019.119029 |
0.415 |
|
| 2019 |
Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, et al. Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature. PMID 31776516 DOI: 10.1038/s41586-019-1795-x |
0.554 |
|
| 2019 |
Hassett MR, Roepe PD. Origin and Spread of Evolving Artemisinin-Resistant Malarial Parasites in Southeast Asia. The American Journal of Tropical Medicine and Hygiene. PMID 31642425 DOI: 10.4269/Ajtmh.19-0379 |
0.475 |
|
| 2019 |
Thornton LB, Teehan P, Floyd K, Cochrane C, Bergmann A, Riegel B, Stasic AJ, Di Cristina M, Moreno SNJ, Roepe PD, Dou Z. An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion. Plos Pathogens. 15: e1007775. PMID 31170269 DOI: 10.1371/Journal.Ppat.1007775 |
0.403 |
|
| 2019 |
Heller LE, Roepe PD. Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance. Tropical Medicine and Infectious Disease. 4. PMID 31167396 DOI: 10.3390/Tropicalmed4020089 |
0.461 |
|
| 2018 |
Heller LE, Roepe PD. Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive vs Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites. Biochemistry. PMID 30513202 DOI: 10.1021/Acs.Biochem.8B00959 |
0.365 |
|
| 2018 |
Heller LE, Goggins E, Roepe PD. Dihydroartemisinin - Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and Relationship to Emerging Artemisinin Resistance. Biochemistry. PMID 30512926 DOI: 10.1021/Acs.Biochem.8B00960 |
0.511 |
|
| 2018 |
Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA. Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Scientific Reports. 8: 13578. PMID 30206341 DOI: 10.1038/S41598-018-31715-9 |
0.526 |
|
| 2018 |
Hassett MR, Roepe PD. PIK-ing New Malaria Chemotherapy. Trends in Parasitology. PMID 29934102 DOI: 10.1016/J.Pt.2018.06.003 |
0.326 |
|
| 2017 |
Hassett MR, Riegel BE, Callaghan PS, Roepe PD. Analysis of Plasmodium vivax Chloroquine Resistance Transporter Mutant Isoforms. Biochemistry. PMID 28898049 DOI: 10.1021/Acs.Biochem.7B00749 |
0.502 |
|
| 2017 |
Hassett M, Sternberg A, Riegel B, Thomas CJ, Roepe PD. Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3'-Kinase. Biochemistry. PMID 28719180 DOI: 10.1021/Acs.Biochem.7B00416 |
0.395 |
|
| 2017 |
Hassett MR, Sternberg AR, Roepe PD. Inhibition of Human Class I vs Class III Phosphatidylinositol 3'-Kinases. Biochemistry. PMID 28719179 DOI: 10.1021/Acs.Biochem.7B00413 |
0.413 |
|
| 2016 |
Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA. Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. Plos Pathogens. 12: e1005976. PMID 27832198 DOI: 10.1371/Journal.Ppat.1005976 |
0.561 |
|
| 2016 |
Siriwardana A, Iyengar K, Roepe PD. Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype. Antimicrobial Agents and Chemotherapy. 60: 6952-6956. PMID 27600038 DOI: 10.1128/Aac.00857-16 |
0.52 |
|
| 2016 |
Callaghan PS, Siriwardana A, Hassett MR, Roepe PD. Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology. Malaria Journal. 15: 186. PMID 27036417 DOI: 10.1186/S12936-016-1238-1 |
0.479 |
|
| 2015 |
Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, ... ... Roepe PD, et al. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Scientific Reports. 5: 13891. PMID 26403635 DOI: 10.1038/Srep13891 |
0.457 |
|
| 2015 |
Callaghan PS, Hassett MR, Roepe PD. Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT). Biochemistry. 54: 5083-94. PMID 26208441 DOI: 10.1021/Acs.Biochem.5B00412 |
0.541 |
|
| 2014 |
Sherlach KS, Roepe PD. Determination of the cytostatic and cytocidal activities of antimalarial compounds and their combination interactions. Current Protocols in Chemical Biology. 6: 237-48. PMID 25445179 DOI: 10.1002/9780470559277.Ch140125 |
0.475 |
|
| 2014 |
Sherlach KS, Roepe PD. "Drug resistance associated membrane proteins". Frontiers in Physiology. 5: 108. PMID 24688472 DOI: 10.3389/Fphys.2014.00108 |
0.488 |
|
| 2014 |
Roepe PD. To kill or not to kill, that is the question: cytocidal antimalarial drug resistance. Trends in Parasitology. 30: 130-5. PMID 24530127 DOI: 10.1016/J.Pt.2014.01.004 |
0.514 |
|
| 2013 |
Gaviria D, Paguio MF, Turnbull LB, Tan A, Siriwardana A, Ghosh D, Ferdig MT, Sinai AP, Roepe PD. A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum. Plos One. 8: e79059. PMID 24278114 DOI: 10.1371/Journal.Pone.0079059 |
0.831 |
|
| 2013 |
Suberu JO, Gorka AP, Jacobs L, Roepe PD, Sullivan N, Barker GC, Lapkin AA. Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms. Plos One. 8: e80790. PMID 24244716 DOI: 10.1371/Journal.Pone.0080790 |
0.757 |
|
| 2013 |
Gorka AP, Jacobs LM, Roepe PD. Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis. Malaria Journal. 12: 332. PMID 24044530 DOI: 10.1186/1475-2875-12-332 |
0.784 |
|
| 2013 |
Brunner R, Ng CL, Aissaoui H, Akabas MH, Boss C, Brun R, Callaghan PS, Corminboeuf O, Fidock DA, Frame IJ, Heidmann B, Le Bihan A, Jenö P, Mattheis C, Moes S, ... ... Roepe PD, et al. UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. The Journal of Biological Chemistry. 288: 22576-83. PMID 23754276 DOI: 10.1074/Jbc.M113.453159 |
0.802 |
|
| 2013 |
Baro NK, Callaghan PS, Roepe PD. Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms. Biochemistry. 52: 4242-9. PMID 23688277 DOI: 10.1021/Bi400557X |
0.825 |
|
| 2013 |
Gorka AP, de Dios A, Roepe PD. Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities. Journal of Medicinal Chemistry. 56: 5231-46. PMID 23586757 DOI: 10.1021/Jm400282D |
0.78 |
|
| 2013 |
Harinantenaina L, Bowman JD, Brodie PJ, Slebodnick C, Callmander MW, Rakotobe E, Randrianaivo R, Rasamison VE, Gorka A, Roepe PD, Cassera MB, Kingston DG. Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1). Journal of Natural Products. 76: 388-93. PMID 23286240 DOI: 10.1021/Np300750Q |
0.718 |
|
| 2013 |
Gorka AP, Alumasa JN, Sherlach KS, Jacobs LM, Nickley KB, Brower JP, de Dios AC, Roepe PD. Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth. Antimicrobial Agents and Chemotherapy. 57: 356-64. PMID 23114783 DOI: 10.1128/Aac.01709-12 |
0.806 |
|
| 2013 |
Gorka AP, Sherlach KS, de Dios AC, Roepe PD. Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 57: 365-74. PMID 23114754 DOI: 10.1128/Aac.01234-12 |
0.783 |
|
| 2013 |
Suberu JO, Gorka AP, Jacobs L, Roepe PD, Sullivan N, Barker GC, Lapkin AA. Isobologram showing the plot of fractional inhibitory concentration (FIC) of 9-epi-artemisinin (EPI) and artemisitene (ATENE) against FIC of artemisinin (ART) and artesunate (ATSU). Plos One. DOI: 10.1371/Journal.Pone.0080790.G002 |
0.705 |
|
| 2012 |
Sinai AP, Roepe PD. Autophagy in Apicomplexa: a life sustaining death mechanism? Trends in Parasitology. 28: 358-64. PMID 22819059 DOI: 10.1016/J.Pt.2012.06.006 |
0.313 |
|
| 2012 |
Dinio T, Gorka AP, McGinniss A, Roepe PD, Morgan JB. Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 20: 3292-7. PMID 22512909 DOI: 10.1016/J.Bmc.2012.03.042 |
0.807 |
|
| 2012 |
Ghosh D, Walton JL, Roepe PD, Sinai AP. Autophagy is a cell death mechanism in Toxoplasma gondii. Cellular Microbiology. 14: 589-607. PMID 22212386 DOI: 10.1111/J.1462-5822.2011.01745.X |
0.328 |
|
| 2011 |
Pan E, Gorka AP, Alumasa JN, Slebodnick C, Harinantenaina L, Brodie PJ, Roepe PD, Randrianaivo R, Birkinshaw C, Kingston DG. Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest. Journal of Natural Products. 74: 2174-80. PMID 21995542 DOI: 10.1021/Np200499D |
0.778 |
|
| 2011 |
Sherlach KS, Gorka AP, Dantzler A, Roepe PD. Quantification of perchloroethylene residues in dry-cleaned fabrics. Environmental Toxicology and Chemistry / Setac. 30: 2481-7. PMID 21898565 DOI: 10.1002/Etc.665 |
0.689 |
|
| 2011 |
Baro NK, Pooput C, Roepe PD. Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in S. cerevisiae yeast. Biochemistry. 50: 6701-10. PMID 21744797 DOI: 10.1021/Bi200922G |
0.795 |
|
| 2011 |
Paguio MF, Bogle KL, Roepe PD. Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine. Molecular and Biochemical Parasitology. 178: 1-6. PMID 21470564 DOI: 10.1016/J.Molbiopara.2011.03.003 |
0.845 |
|
| 2011 |
Roepe PD. PfCRT-mediated drug transport in malarial parasites. Biochemistry. 50: 163-71. PMID 21142008 DOI: 10.1021/Bi101638N |
0.513 |
|
| 2011 |
Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD. The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex. Journal of Inorganic Biochemistry. 105: 467-75. PMID 20864177 DOI: 10.1016/J.Jinorgbio.2010.08.011 |
0.789 |
|
| 2010 |
Patel JJ, Thacker D, Tan JC, Pleeter P, Checkley L, Gonzales JM, Deng B, Roepe PD, Cooper RA, Ferdig MT. Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross. Molecular Microbiology. 78: 770-87. PMID 20807203 DOI: 10.1111/J.1365-2958.2010.07366.X |
0.438 |
|
| 2010 |
Pleeter P, Lekostaj JK, Roepe PD. Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue. Molecular and Biochemical Parasitology. 173: 158-61. PMID 20546803 DOI: 10.1016/J.Molbiopara.2010.05.012 |
0.833 |
|
| 2009 |
Roepe PD. Malarial parasite pathogenesis and drug targets. F1000 Biology Reports. 1: 18. PMID 20948668 DOI: 10.3410/B1-18 |
0.446 |
|
| 2009 |
Cabrera M, Paguio MF, Xie C, Roepe PD. Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity. Biochemistry. 48: 11152-4. PMID 19883122 DOI: 10.1021/Bi901765V |
0.807 |
|
| 2009 |
Cabrera M, Natarajan J, Paguio MF, Wolf C, Urbach JS, Roepe PD. Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe. Biochemistry. 48: 9471-81. PMID 19728740 DOI: 10.1021/Bi901034R |
0.829 |
|
| 2009 |
Paguio MF, Cabrera M, Roepe PD. Chloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe. Biochemistry. 48: 9482-91. PMID 19725576 DOI: 10.1021/Bi901035J |
0.814 |
|
| 2009 |
Iwaniuk DP, Whetmore ED, Rosa N, Ekoue-Kovi K, Alumasa J, de Dios AC, Roepe PD, Wolf C. Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain. Bioorganic & Medicinal Chemistry. 17: 6560-6. PMID 19703776 DOI: 10.1016/J.Bmc.2009.08.003 |
0.772 |
|
| 2009 |
Roepe PD, Ferdig MT. P. falciparum Na(+)/H(+) exchanger (PfNHE) function and quinine resistance (QNR) [Reply to: Spillman et al. "Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger" Mol. Biochem. Parasitol. 2008 162 (1) 96-99]. Molecular and Biochemical Parasitology. 166: 1-2; author reply 3. PMID 19428665 DOI: 10.1016/J.Molbiopara.2009.01.008 |
0.409 |
|
| 2009 |
Roepe PD. Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria. Future Microbiology. 4: 441-55. PMID 19416013 DOI: 10.2217/Fmb.09.15 |
0.521 |
|
| 2009 |
Hou Y, Cao S, Brodie PJ, Callmander MW, Ratovoson F, Rakotobe EA, Rasamison VE, Ratsimbason M, Alumasa JN, Roepe PD, Kingston DG. Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest. Bioorganic & Medicinal Chemistry. 17: 2871-6. PMID 19282186 DOI: 10.1016/J.Bmc.2009.02.022 |
0.742 |
|
| 2009 |
Casabianca LB, Kallgren JB, Natarajan JK, Alumasa JN, Roepe PD, Wolf C, de Dios AC. Antimalarial drugs and heme in detergent micelles: An NMR study. Journal of Inorganic Biochemistry. 103: 745-8. PMID 19223262 DOI: 10.1016/J.Jinorgbio.2009.01.013 |
0.762 |
|
| 2009 |
Ekoue-Kovi K, Yearick K, Iwaniuk DP, Natarajan JK, Alumasa J, de Dios AC, Roepe PD, Wolf C. Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas. Bioorganic & Medicinal Chemistry. 17: 270-83. PMID 19041248 DOI: 10.1016/J.Bmc.2008.11.009 |
0.793 |
|
| 2008 |
Lekostaj JK, Natarajan JK, Paguio MF, Wolf C, Roepe PD. Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine. Biochemistry. 47: 10394-406. PMID 18767816 DOI: 10.1021/Bi8010658 |
0.816 |
|
| 2008 |
Witola WH, El Bissati K, Pessi G, Xie C, Roepe PD, Mamoun CB. Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects. The Journal of Biological Chemistry. 283: 27636-43. PMID 18694927 DOI: 10.1074/Jbc.M804360200 |
0.336 |
|
| 2008 |
Casabianca LB, An D, Natarajan JK, Alumasa JN, Roepe PD, Wolf C, de Dios AC. Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Inorganic Chemistry. 47: 6077-81. PMID 18533646 DOI: 10.1021/Ic800440D |
0.72 |
|
| 2008 |
Natarajan JK, Alumasa JN, Yearick K, Ekoue-Kovi KA, Casabianca LB, de Dios AC, Wolf C, Roepe PD. 4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria. Journal of Medicinal Chemistry. 51: 3466-79. PMID 18512900 DOI: 10.1021/Jm701478A |
0.752 |
|
| 2008 |
Yearick K, Ekoue-Kovi K, Iwaniuk DP, Natarajan JK, Alumasa J, de Dios AC, Roepe PD, Wolf C. Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines. Journal of Medicinal Chemistry. 51: 1995-8. PMID 18345611 DOI: 10.1021/Jm800106U |
0.775 |
|
| 2008 |
Gligorijevic B, Purdy K, Elliott DA, Cooper RA, Roepe PD. Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy. Molecular and Biochemical Parasitology. 159: 7-23. PMID 18281110 DOI: 10.1016/J.Molbiopara.2007.12.014 |
0.733 |
|
| 2008 |
Lekostaj JK, Amoah LE, Roepe PD. A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform. Molecular and Biochemical Parasitology. 157: 107-11. PMID 18006157 DOI: 10.1016/J.Molbiopara.2007.09.008 |
0.812 |
|
| 2007 |
Amoah LE, Lekostaj JK, Roepe PD. Heterologous expression and ATPase activity of mutant versus wild type PfMDR1 protein. Biochemistry. 46: 6060-73. PMID 17469853 DOI: 10.1021/Bi7002026 |
0.848 |
|
| 2007 |
Bennett TN, Patel J, Ferdig MT, Roepe PD. Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance. Molecular and Biochemical Parasitology. 153: 48-58. PMID 17353059 DOI: 10.1016/J.Molbiopara.2007.01.018 |
0.843 |
|
| 2006 |
Gligorijevic B, Bennett T, McAllister R, Urbach JS, Roepe PD. Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria. Biochemistry. 45: 12411-23. PMID 17029397 DOI: 10.1021/Bi0610348 |
0.816 |
|
| 2006 |
Gligorijevic B, McAllister R, Urbach JS, Roepe PD. Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria. Biochemistry. 45: 12400-10. PMID 17029396 DOI: 10.1021/Bi061033F |
0.729 |
|
| 2006 |
Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Molecular and Biochemical Parasitology. 150: 288-99. PMID 17014918 DOI: 10.1016/J.Molbiopara.2006.09.001 |
0.495 |
|
| 2005 |
Bennett TN, Kosar AD, Roepe PD. Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells. Molecular and Biochemical Parasitology. 139: 261-5. PMID 15664660 DOI: 10.1016/J.Molbiopara.2004.11.006 |
0.771 |
|
| 2004 |
de Dios AC, Casabianca LB, Kosar A, Roepe PD. Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution. Inorganic Chemistry. 43: 8078-84. PMID 15578847 DOI: 10.1021/Ic0489948 |
0.381 |
|
| 2004 |
Zhang H, Paguio M, Roepe PD. The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine. Biochemistry. 43: 8290-6. PMID 15222741 DOI: 10.1021/Bi049137I |
0.842 |
|
| 2004 |
Bennett TN, Paguio M, Gligorijevic B, Seudieu C, Kosar AD, Davidson E, Roepe PD. Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy. Antimicrobial Agents and Chemotherapy. 48: 1807-10. PMID 15105139 DOI: 10.1128/Aac.48.5.1807-1810.2004 |
0.783 |
|
| 2004 |
Bennett TN, Kosar AD, Ursos LM, Dzekunov S, Singh Sidhu AB, Fidock DA, Roepe PD. Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH. Molecular and Biochemical Parasitology. 133: 99-114. PMID 14668017 DOI: 10.1016/J.Molbiopara.2003.09.008 |
0.806 |
|
| 2003 |
Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA. Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter. The Journal of Biological Chemistry. 278: 33593-601. PMID 12813054 DOI: 10.1074/Jbc.M302215200 |
0.803 |
|
| 2003 |
Howard EM, Roepe PD. Purified human MDR 1 modulates membrane potential in reconstituted proteoliposomes. Biochemistry. 42: 3544-55. PMID 12653559 DOI: 10.1021/Bi026706I |
0.683 |
|
| 2002 |
Howard EM, Zhang H, Roepe PD. A novel transporter, Pfcrt, confers antimalarial drug resistance. The Journal of Membrane Biology. 190: 1-8. PMID 12422267 DOI: 10.1007/S00232-002-1019-3 |
0.817 |
|
| 2002 |
Zhang H, Howard EM, Roepe PD. Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast. The Journal of Biological Chemistry. 277: 49767-75. PMID 12351620 DOI: 10.1074/Jbc.M204005200 |
0.771 |
|
| 2002 |
Ursos LM, Roepe PD. Chloroquine resistance in the malarial parasite, Plasmodium falciparum. Medicinal Research Reviews. 22: 465-91. PMID 12210555 DOI: 10.1002/Med.10016 |
0.817 |
|
| 2002 |
Leed A, DuBay K, Ursos LM, Sears D, De Dios AC, Roepe PD. Solution structures of antimalarial drug-heme complexes. Biochemistry. 41: 10245-55. PMID 12162739 DOI: 10.1021/Bi020195I |
0.795 |
|
| 2002 |
Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Molecular Pharmacology. 61: 35-42. PMID 11752204 DOI: 10.1124/Mol.61.1.35 |
0.784 |
|
| 2001 |
Roepe PD. pH and multidrug resistance Novartis Foundation Symposium. 240: 232-247. PMID 11727933 DOI: 10.1002/0470868716.Ch16 |
0.436 |
|
| 2001 |
Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proceedings of the National Academy of Sciences of the United States of America. 98: 12689-94. PMID 11675500 DOI: 10.1073/Pnas.221440898 |
0.78 |
|
| 2001 |
Ursos LM, DuBay KF, Roepe PD. Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena. Molecular and Biochemical Parasitology. 112: 11-7. PMID 11166382 DOI: 10.1016/S0166-6851(00)00342-X |
0.79 |
|
| 2000 |
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Molecular Cell. 6: 861-71. PMID 11090624 DOI: 10.1016/S1097-2765(05)00077-8 |
0.785 |
|
| 2000 |
Ursos LM, Dzekunov SM, Roepe PD. The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine. Molecular and Biochemical Parasitology. 110: 125-34. PMID 10989150 DOI: 10.1016/S0166-6851(00)00262-0 |
0.81 |
|
| 2000 |
Dzekunov SM, Ursos LM, Roepe PD. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine. Molecular and Biochemical Parasitology. 110: 107-24. PMID 10989149 DOI: 10.1016/S0166-6851(00)00261-9 |
0.807 |
|
| 2000 |
Roepe PD. What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance? Current Pharmaceutical Design. 6: 241-260. PMID 10637378 DOI: 10.2174/1381612003401163 |
0.476 |
|
| 1999 |
Martiney JA, Ferrer AS, Cerami A, Dzekunov S, Roepe P. Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for chloride-dependent ionic regulation. Novartis Foundation Symposium. 226: 265-77; discussion 2. PMID 10645551 DOI: 10.1002/9780470515730.Ch18 |
0.514 |
|
| 1999 |
Weisburg JH, Roepe PD, Dzekunov S, Scheinberg DA. Intracellular ph and multidrug resistance regulate complement-mediated cytotoxicity of nucleated human cells Journal of Biological Chemistry. 274: 10877-10888. PMID 10196165 DOI: 10.1074/Jbc.274.16.10877 |
0.336 |
|
| 1999 |
Santai CT, Fritz F, Roepe PD. Effects of ion gradients on H+ transport mediated by human MDR 1 protein. Biochemistry. 38: 4227-34. PMID 10194339 DOI: 10.1021/Bi981930M |
0.366 |
|
| 1999 |
Fritz F, Howard EM, Hoffman MM, Roepe PD. Evidence for altered ion transport in Saccharomyces cerevisiae overexpressing human MDR 1 protein. Biochemistry. 38: 4214-26. PMID 10194338 DOI: 10.1021/Bi981929N |
0.695 |
|
| 1999 |
Roepe PD, Martiney JA. Are ion-exchange processes central to understanding drug-resistance phenomena? Trends in Pharmacological Sciences. 20: 62-65. PMID 10101966 DOI: 10.1016/S0165-6147(98)01282-6 |
0.516 |
|
| 1998 |
Roepe PD, Sharom FJ. The P-glycoprotein efflux pump: How does it transport drugs? (multiple letters) Journal of Membrane Biology. 166: 71-73. PMID 9784587 DOI: 10.1007/S002329900448 |
0.415 |
|
| 1997 |
Robinson LJ, Roberts WK, Ling TT, Lamming D, Sternberg SS, Roepe PD. Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry. 36: 11169-78. PMID 9287159 DOI: 10.1021/Bi9627830 |
0.439 |
|
| 1997 |
Hoffman MM, Roepe PD. Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression Biochemistry. 36: 11153-11168. PMID 9287158 DOI: 10.1021/Bi970530G |
0.405 |
|
| 1997 |
Wei LY, Hoffman MM, Roepe PD. Altered pHi regulation in 3T3/CFTR clones and their chemotherapeutic drug-selected derivatives. The American Journal of Physiology. 272: C1642-53. PMID 9176156 |
0.307 |
|
| 1996 |
Roepe PD, Wei LY, Hoffman MM, Fritz F. Altered drug translocation mediated by the MDR protein: direct, indirect, or both? Journal of Bioenergetics and Biomembranes. 28: 541-55. PMID 8953386 |
0.378 |
|
| 1996 |
Hoffman MM, Wei LY, Roepe PD. Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance? The Journal of General Physiology. 108: 295-313. PMID 8894978 |
0.398 |
|
| 1996 |
Robinson LJ, Roepe PD. Effects of membrane potential versus pH(i) on the cellular retention of doxorubicin analyzed via a comparison between cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance (MDR) transfectants Biochemical Pharmacology. 52: 1081-1095. PMID 8831728 DOI: 10.1016/0006-2952(96)81736-9 |
0.401 |
|
| 1996 |
Weisburg JH, Curcio M, Caron PC, Raghu G, Mechetner EB, Roepe PD, Scheinberg DA. The multidrug resistance phenotype confers immunological resistance Journal of Experimental Medicine. 183: 2699-2704. PMID 8676093 DOI: 10.1084/Jem.183.6.2699 |
0.347 |
|
| 1995 |
Wei LY, Stutts MJ, Hoffman MM, Roepe PD. Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype. Biophysical Journal. 69: 883-95. PMID 8519988 DOI: 10.1016/S0006-3495(95)79962-3 |
0.378 |
|
| 1994 |
Luz JG, Wei LY, Basu S, Roepe PD. Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells. Biochemistry. 33: 7239-49. PMID 7911682 DOI: 10.1021/Bi00189A028 |
0.377 |
|
| 1994 |
Wei LY, Roepe PD. Low external pH and osmotic shock increase the expression of human MDR protein. Biochemistry. 33: 7229-38. PMID 7911681 DOI: 10.1021/Bi00189A027 |
0.396 |
|
| 1994 |
Roepe PD. Drug transport mediated by P-glycoprotein may be secondary to electrochemical perturbations of the plasma membrane Trends in Pharmacological Sciences. 15: 445-446. PMID 7886815 DOI: 10.1016/0165-6147(94)90056-6 |
0.372 |
|
| 1993 |
Roepe PD, Wei LY, Cruz J, Carlson D. Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein. Biochemistry. 32: 11042-56. PMID 8105888 |
0.342 |
|
| 1992 |
Roepe PD. Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein Biochemistry. 31: 12555-12564. PMID 1361758 |
0.324 |
|
| Show low-probability matches. |