Nathan W. Luedtke, Ph.D. - Publications

Affiliations: 
2003 University of California, San Diego, La Jolla, CA 
Area:
Biochemistry, Organic Chemistry, General Biophysics

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Copp W, Karimi A, Yang T, Guarné A, Luedtke NW. Fluorescent molecular rotors detect -methylguanine dynamics and repair in duplex DNA. Chemical Communications (Cambridge, England). PMID 38190113 DOI: 10.1039/d3cc04782b  0.716
2023 Basran K, Bujalska A, Karimi A, Luedtke NW. Formal [4 + 2] Cycloadditions of Maleimides on Duplex DNA. Bioconjugate Chemistry. PMID 37290129 DOI: 10.1021/acs.bioconjchem.3c00090  0.676
2023 Karimi A, Wang K, Basran K, Copp W, Luedtke NW. A Bright and Ionizable Cytosine Mimic for -Motif Structures. Bioconjugate Chemistry. PMID 37196003 DOI: 10.1021/acs.bioconjchem.3c00055  0.685
2020 Messikommer A, Seipel K, Byrne S, Valk PJM, Pabst T, Luedtke NW. RNA Targeting in Acute Myeloid Leukemia. Acs Pharmacology & Translational Science. 3: 1225-1232. PMID 33344899 DOI: 10.1021/acsptsci.0c00120  0.309
2020 Schreier VN, Loehr MO, Deng T, Lattmann E, Hajnal A, Neuhauss SCF, Luedtke NW. Fluorescent dATP for DNA Synthesis . Acs Chemical Biology. PMID 33108866 DOI: 10.1021/acschembio.0c00654  0.349
2020 Karimi A, Börner R, Mata G, Luedtke NW. A Highly Fluorescent Nucleobase Molecular Rotor. Journal of the American Chemical Society. 142: 14422-14426. PMID 32786749 DOI: 10.1021/jacs.0c05180  0.673
2019 Tera M, Luedtke NW. Three-Component Bioorthogonal Reactions on Cellular DNA and RNA. Bioconjugate Chemistry. PMID 31697067 DOI: 10.1021/Acs.Bioconjchem.9B00630  0.363
2019 Schmidt OP, Jurt S, Johannsen S, Karimi A, Sigel RKO, Luedtke NW. Concerted dynamics of metallo-base pairs in an A/B-form helical transition. Nature Communications. 10: 4818. PMID 31645548 DOI: 10.1038/S41467-019-12440-X  0.692
2019 Johnson A, Karimi A, Luedtke NW. Enzymatic Incorporation of a Coumarin-Guanine Base Pair. Angewandte Chemie (International Ed. in English). PMID 31486266 DOI: 10.1002/Anie.201910059  0.675
2018 Tera M, Harati Taji Z, Luedtke NW. Intercalation-enhanced "Click" Crosslinking of DNA. Angewandte Chemie (International Ed. in English). PMID 30240107 DOI: 10.1002/Anie.201808054  0.447
2018 Tera M, Glasauer SMK, Luedtke NW. In Vivo Incorporation of Azide Groups into DNA by Using Membrane-Permeable Nucleotide Triesters. Chembiochem : a European Journal of Chemical Biology. PMID 29953711 DOI: 10.1002/Cbic.201800351  0.396
2018 Schmidt OP, Benz AS, Mata G, Luedtke NW. HgII binds to C-T mismatches with high affinity. Nucleic Acids Research. PMID 29901748 DOI: 10.1093/Nar/Gky499  0.359
2018 Triemer T, Messikommer A, Glasauer SMK, Alzeer J, Paulisch MH, Luedtke NW. Superresolution imaging of individual replication forks reveals unexpected prodrug resistance mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378947 DOI: 10.1073/Pnas.1714790115  0.728
2017 Naik A, Alzeer J, Triemer T, Bujalska A, Luedtke NW. Chemoselective Modification of Vinyl DNA by Triazolinediones. Angewandte Chemie (International Ed. in English). PMID 28561928 DOI: 10.1002/Anie.201702554  0.755
2017 Marsoner T, Schmidt OP, Triemer T, Luedtke NW. DNA-Targeted Inhibition of MGMT. Chembiochem : a European Journal of Chemical Biology. PMID 28177192 DOI: 10.1002/Cbic.201600652  0.407
2016 Schmidt OP, Mata G, Luedtke NW. Fluorescent Base Analog Reveals T-Hg(II)-T Base Pairs Have High Kinetic Stabilities that Perturb DNA Metabolism. Journal of the American Chemical Society. PMID 27709934 DOI: 10.1021/Jacs.6B09044  0.385
2016 Mata G, Schmidt OP, Luedtke NW. A fluorescent surrogate of thymidine in duplex DNA. Chemical Communications (Cambridge, England). PMID 26954231 DOI: 10.1039/C5Cc09552B  0.419
2016 Seyfried MS, Alzeer J, Luedtke NW. Molecular Design and Synthesis of a Planar Telomestatin Analogue European Journal of Organic Chemistry. 2016: 367-372. DOI: 10.1002/Ejoc.201501103  0.689
2015 Oesch D, Luedtke NW. Fluorescent chemosensors of carbohydrate triols exhibiting TICT emissions. Chemical Communications (Cambridge, England). 51: 12641-4. PMID 26160311 DOI: 10.1039/C5Cc03857J  0.335
2015 Neef AB, Pernot L, Schreier VN, Scapozza L, Luedtke NW. A Bioorthogonal Chemical Reporter of Viral Infection. Angewandte Chemie (International Ed. in English). 54: 7911-4. PMID 25974835 DOI: 10.1002/Anie.201500250  0.336
2015 Mata G, Luedtke NW. Fluorescent probe for proton-coupled DNA folding revealing slow exchange of i-motif and duplex structures. Journal of the American Chemical Society. 137: 699-707. PMID 25423623 DOI: 10.1021/Ja508741U  0.45
2014 Rieder U, Luedtke NW. Alkene-tetrazine ligation for imaging cellular DNA. Angewandte Chemie (International Ed. in English). 53: 9168-72. PMID 24981416 DOI: 10.1002/Anie.201403580  0.411
2014 Neef AB, Luedtke NW. An azide-modified nucleoside for metabolic labeling of DNA. Chembiochem : a European Journal of Chemical Biology. 15: 789-93. PMID 24644275 DOI: 10.1002/Cbic.201400037  0.437
2014 Rieder U, Luedtke NW. Frontispiece: Alkene-Tetrazine Ligation for Imaging Cellular DNA Angewandte Chemie International Edition. 53: n/a-n/a. DOI: 10.1002/Anie.201483571  0.368
2013 Wang IH, Suomalainen M, Andriasyan V, Kilcher S, Mercer J, Neef A, Luedtke NW, Greber UF. Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe. 14: 468-80. PMID 24139403 DOI: 10.1016/J.Chom.2013.09.004  0.359
2013 Vummidi BR, Noreen F, Alzeer J, Moelling K, Luedtke NW. Photodynamic agents with anti-metastatic activities. Acs Chemical Biology. 8: 1737-46. PMID 23672401 DOI: 10.1021/Cb400008T  0.692
2013 Mata G, Luedtke NW. Synthesis and solvatochromic fluorescence of biaryl pyrimidine nucleosides. Organic Letters. 15: 2462-5. PMID 23656574 DOI: 10.1021/Ol400930S  0.334
2013 Vummidi BR, Alzeer J, Luedtke NW. Fluorescent probes for G-quadruplex structures. Chembiochem : a European Journal of Chemical Biology. 14: 540-58. PMID 23440895 DOI: 10.1002/Cbic.201200612  0.748
2012 Mata G, Luedtke NW. Stereoselective N-glycosylation of 2-deoxythioribosides for fluorescent nucleoside synthesis. The Journal of Organic Chemistry. 77: 9006-17. PMID 22974063 DOI: 10.1021/Jo3014929  0.391
2012 Neef AB, Samain F, Luedtke NW. Metabolic labeling of DNA by purine analogues in vivo. Chembiochem : a European Journal of Chemical Biology. 13: 1750-3. PMID 22815258 DOI: 10.1002/Cbic.201200253  0.416
2012 Ren J, Wang J, Wang J, Luedtke NW, Wang E. Enantioselective and label-free detection of oligopeptide via fluorescent indicator displacement. Biosensors & Bioelectronics. 35: 401-6. PMID 22483357 DOI: 10.1016/J.Bios.2012.03.028  0.393
2012 Hentschel S, Alzeer J, Angelov T, Schärer OD, Luedtke NW. Synthesis of DNA interstrand cross-links using a photocaged nucleobase. Angewandte Chemie (International Ed. in English). 51: 3466-9. PMID 22344895 DOI: 10.1002/Anie.201108018  0.743
2012 Dumas A, Luedtke NW. Site-specific control of N7-metal coordination in DNA by a fluorescent purine derivative. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 245-54. PMID 22143992 DOI: 10.1002/Chem.201102349  0.417
2012 Ren J, Wang J, Wang J, Luedtke NW, Wang E. Contribution of potassium ion and split modes of G-quadruplex to the sensitivity and selectivity of label-free sensor toward DNA detection using fluorescence. Biosensors & Bioelectronics. 31: 316-22. PMID 22104647 DOI: 10.1016/J.Bios.2011.10.038  0.391
2012 Hentschel S, Alzeer J, Angelov T, Schärer OD, Luedtke NW. Synthese von DNA-Interstrang-Crosslinks unter Verwendung einer photoaktivierbaren Nucleobase Angewandte Chemie. 124: 3523-3526. DOI: 10.1002/Ange.201108018  0.746
2011 Neef AB, Luedtke NW. Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. Proceedings of the National Academy of Sciences of the United States of America. 108: 20404-9. PMID 22143759 DOI: 10.1073/Pnas.1101126108  0.395
2011 Dumas A, Luedtke NW. Fluorescence properties of 8-(2-pyridyl)guanine "2PyG" as compared to 2-aminopurine in DNA. Chembiochem : a European Journal of Chemical Biology. 12: 2044-51. PMID 21786378 DOI: 10.1002/Cbic.201100214  0.405
2011 Dumas A, Luedtke NW. Highly fluorescent guanosine mimics for folding and energy transfer studies. Nucleic Acids Research. 39: 6825-34. PMID 21551219 DOI: 10.1093/Nar/Gkr281  0.448
2011 Ren J, Qin H, Wang J, Luedtke NW, Wang E, Wang J. Label-free detection of nucleic acids by turn-on and turn-off G-quadruplex-mediated fluorescence. Analytical and Bioanalytical Chemistry. 399: 2763-70. PMID 21267713 DOI: 10.1007/S00216-011-4669-0  0.44
2010 Dumas A, Luedtke NW. Cation-mediated energy transfer in G-quadruplexes revealed by an internal fluorescent probe. Journal of the American Chemical Society. 132: 18004-7. PMID 21125997 DOI: 10.1021/Ja1079578  0.355
2010 Qin H, Ren J, Wang J, Luedtke NW, Wang E. G-quadruplex-modulated fluorescence detection of potassium in the presence of a 3500-fold excess of sodium ions. Analytical Chemistry. 82: 8356-60. PMID 20804164 DOI: 10.1021/Ac101894B  0.333
2010 Alzeer J, Luedtke NW. pH-mediated fluorescence and G-quadruplex binding of amido phthalocyanines. Biochemistry. 49: 4339-48. PMID 20380429 DOI: 10.1021/Bi9020583  0.76
2010 Membrino A, Paramasivam M, Cogoi S, Alzeer J, Luedtke NW, Xodo LE. Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes. Chemical Communications (Cambridge, England). 46: 625-7. PMID 20062883 DOI: 10.1039/B918964E  0.734
2009 Alzeer J, Vummidi BR, Roth PJ, Luedtke NW. Guanidinium-modified phthalocyanines as high-affinity G-quadruplex fluorescent probes and transcriptional regulators. Angewandte Chemie (International Ed. in English). 48: 9362-5. PMID 19882707 DOI: 10.1002/Anie.200903685  0.75
2009 Alzeer J, Roth PJ, Luedtke NW. An efficient two-step synthesis of metal-free phthalocyanines using a Zn(ii) template. Chemical Communications (Cambridge, England). 1970-1. PMID 19333460 DOI: 10.1039/B822985F  0.694
2009 Luedtke NW. Targeting G-quadruplex DNA with small molecules Chimia. 63: 134-139. DOI: 10.2533/Chimia.2009.134  0.439
2005 Boer J, Blount KF, Luedtke NW, Elson-Schwab L, Tor Y. RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides. Angewandte Chemie (International Ed. in English). 44: 927-32. PMID 15630712 DOI: 10.1002/Anie.200461182  0.526
2005 Luedtke NW, Liu Q, Tor Y. On the electronic structure of ethidium. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 495-508. PMID 15549769 DOI: 10.1002/Chem.200400559  0.491
2004 Aldrich-Wright J, Brodie C, Glazer EC, Luedtke NW, Elson-Schwab L, Tor Y. Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+. Chemical Communications (Cambridge, England). 1018-9. PMID 15069523 DOI: 10.1039/B316917K  0.748
2004 Goodman M, Baker TJ, Smith N, Creighton CJ, Luedtke NW, Tor Y. New Reactions and Structures for Peptidomimetic Drug Design Cheminform. 35. DOI: 10.1002/chin.200416267  0.422
2004 Aldrich-Wright J, Brodie C, Glazer EC, Luedtke NW, Elson-Schwab L, Tor Y. Symmetrical dinuclear complexes with high DNA affinity based on Ru(dpq)2(phen)2+ Chemical Communications. 10: 1018-1019.  0.737
2003 Luedtke NW, Liu Q, Tor Y. Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium. Bioorganic & Medicinal Chemistry. 11: 5235-47. PMID 14604688 DOI: 10.1016/J.Bmc.2003.08.006  0.59
2003 Luedtke NW, Carmichael P, Tor Y. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine. Journal of the American Chemical Society. 125: 12374-5. PMID 14531657 DOI: 10.1021/Ja0360135  0.533
2003 Luedtke NW, Liu Q, Tor Y. RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Biochemistry. 42: 11391-403. PMID 14516190 DOI: 10.1021/Bi034766Y  0.622
2003 Luedtke NW, Hwang JS, Nava E, Gut D, Kol M, Tor Y. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide. Nucleic Acids Research. 31: 5732-40. PMID 14500837 DOI: 10.1093/Nar/Gkg758  0.62
2003 Luedtke NW, Tor Y. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors. Biopolymers. 70: 103-19. PMID 12925996 DOI: 10.1002/Bip.10428  0.577
2003 Fineberg K, Fineberg T, Graessmann A, Luedtke NW, Tor Y, Lixin R, Jans DA, Loyter A. Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules. Biochemistry. 42: 2625-33. PMID 12614157 DOI: 10.1021/Bi0206199  0.548
2003 Brodie CR, Aldrich-Wright JR, Glazer E, Luedtke N, Tor Y. Synthesis and DNA binding of bisintercalating complexes of the type [(dpq)2Ru(phen-n-SOS-n-phen)Ru(dpq)2]4+ Journal of Inorganic Biochemistry. 96: 105. DOI: 10.1016/S0162-0134(03)80572-X  0.738
2002 Luedtke NW, Hwang JS, Glazer EC, Gut D, Kol M, Tor Y. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA. Chembiochem : a European Journal of Chemical Biology. 3: 766-71. PMID 12203975 DOI: 10.1002/1439-7633(20020802)3:8<766::Aid-Cbic766>3.0.Co;2-X  0.727
2001 Kirk SR, Luedtke NW, Tor Y. 2-Aminopurine as a real-time probe of enzymatic cleavage and inhibition of hammerhead ribozymes. Bioorganic & Medicinal Chemistry. 9: 2295-301. PMID 11553468 DOI: 10.1016/S0968-0896(01)00123-7  0.715
2001 Liu Q, Luedtke NW, Tor Y. A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents Tetrahedron Letters. 42: 1445-1447. DOI: 10.1016/S0040-4039(00)02289-9  0.526
2001 Luedtke NW, Baker TJ, Goodman M, Tor Y. ChemInform Abstract: Guanidinoglycosides: A Novel Family of RNA Ligands. Cheminform. 32: no-no. DOI: 10.1002/chin.200116225  0.453
2000 Baker TJ, Luedtke NW, Tor Y, Goodman M. Synthesis and anti-HIV activity of guanidinoglycosides. The Journal of Organic Chemistry. 65: 9054-8. PMID 11149851 DOI: 10.1021/Jo001142E  0.512
2000 Luedtke NW, Tor Y. A Novel Solid-Phase Assembly for Identifying Potent and Selective RNA Ligands We thank Professors David Wilson and David Boykin for a generous gift of the aromatic amidine derivatives and Professor Kol for a generous gift of eilatin-containing complexes. We are grateful to Dr. Georg Schlechtingen and Professor Murray Goodman for assistance with peptide synthesis and to Ibis Therapeutics for partial support. N.W.L. is supported by a National Institute of Health Molecular Biophysics Training Grant (GM 08326). Angewandte Chemie (International Ed. in English). 39: 1788-1790. PMID 10934362 DOI: 10.1002/(Sici)1521-3773(20000515)39:10<1788::Aid-Anie1788>3.0.Co;2-6  0.535
2000 Friedler A, Friedler D, Luedtke NW, Tor Y, Loyter A, Gilon C. Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif. The Journal of Biological Chemistry. 275: 23783-9. PMID 10764789 DOI: 10.1074/Jbc.M002200200  0.54
2000 Kirk SR, Luedtke NW, Tor Y. Neomycin-acridine conjugate: A potent inhibitor of Rev-RRE binding [16] Journal of the American Chemical Society. 122: 980-981. DOI: 10.1021/Ja993387I  0.671
2000 Luedtke NW, Baker TJ, Goodman M, Tor Y. Guanidinoglycosides: A novel family of RNA ligands [21] Journal of the American Chemical Society. 122: 12035-12036. DOI: 10.1021/Ja002421M  0.538
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