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Michael A. Kalwat, Ph.D. - Publications

Affiliations: 
2007-2012 Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
 2012-2020 Pharmacology University of Texas Southwester Medical Center, Dallas, TX, United States 
 2020- Lilly Diabetes Center of Excellence Indiana Biosciences Research Institute 
Area:
Diabetes, Islet Biology, regulation of hormone secretion
Website:
www.linkedin.com/in/michael-kalwat
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Roy G, Syed R, Lazaro O, Robertson S, McCabe SD, Rodriguez D, Mawla AM, Johnson TS, Kalwat MA. Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning. Biorxiv : the Preprint Server For Biology. PMID 38328172 DOI: 10.1101/2024.01.18.576260  0.72
2024 Mukherjee N, Contreras CJ, Lin L, Colglazier KA, Mather EG, Kalwat MA, Esser N, Kahn SE, Templin AT. RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes. Molecular Metabolism. 101877. PMID 38218538 DOI: 10.1016/j.molmet.2024.101877  0.367
2023 Kalwat MA, Rodrigues-Dos-Santos K, Binns DD, Wei S, Zhou A, Evans MR, Posner BA, Roth MG, Cobb MH. Small molecule glucagon release inhibitors with activity in human islets. Frontiers in Endocrinology. 14: 1114799. PMID 37152965 DOI: 10.3389/fendo.2023.1114799  0.587
2022 Goode RA, Hum JM, Kalwat MA. Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement. Endocrinology. 164. PMID 36412119 DOI: 10.1210/endocr/bqac193  0.383
2022 Rodrigues-Dos-Santos K, Roy G, Binns DD, Grzemska MG, Barella LF, Armoo F, McCoy MK, Huynh AV, Yang JZ, Posner BA, Cobb MH, Kalwat MA. Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function. Endocrinology. PMID 35641126 DOI: 10.1210/endocr/bqac081  0.436
2021 Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH. The pancreatic β cell response to secretory demands and adaption to stress. Endocrinology. PMID 34407177 DOI: 10.1210/endocr/bqab173  0.69
2021 Kalwat MA. Correction to: High-Throughput Screening for Insulin Secretion Modulators. Methods in Molecular Biology (Clifton, N.J.). 2233: C1. PMID 33502748 DOI: 10.1007/978-1-0716-1044-2_22  0.407
2021 Kalwat MA. High-Throughput Screening for Insulin Secretion Modulators. Methods in Molecular Biology (Clifton, N.J.). 2233: 131-138. PMID 33222132 DOI: 10.1007/978-1-0716-1044-2_9  0.466
2020 Kalwat MA, Huang Z, Binns DD, McGlynn K, Cobb MH. α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology. 8: 576396. PMID 33178692 DOI: 10.3389/fcell.2020.576396  0.647
2019 Kalwat M, Cobb MH. Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate. Journal of Visualized Experiments : Jove. PMID 31305532 DOI: 10.3791/59926  0.605
2018 Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology. PMID 30352794 DOI: 10.1085/Jgp.201812177  0.783
2017 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways. Acs Sensors. 2: 316. PMID 28723136 DOI: 10.1021/acssensors.7b00012  0.658
2017 Kalwat MA, Cobb M. Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics. PMID 28527919 DOI: 10.1016/j.pharmthera.2017.05.003  0.663
2017 Guerra ML, Kalwat MA, McGlynn K, Cobb MH. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186. PMID 28174684 DOI: 10.1002/2211-5463.12172  0.782
2016 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212. PMID 27819058 DOI: 10.1021/Acssensors.6B00433  0.67
2016 Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH. Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology. PMID 26828310 DOI: 10.1021/acschembio.5b00993  0.57
2013 Kalwat MA, Thurmond DC. Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells. Experimental & Molecular Medicine. 45: e37. PMID 23969997 DOI: 10.1038/emm.2013.73  0.71
2013 Kalwat MA, Yoder SM, Wang Z, Thurmond DC. A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells. Biochemical Pharmacology. 85: 808-16. PMID 23246867 DOI: 10.1016/J.Bcp.2012.12.003  0.719
2012 Ramalingam L, Oh E, Yoder SM, Brozinick JT, Kalwat MA, Groffen AJ, Verhage M, Thurmond DC. Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity. Diabetes. 61: 2424-32. PMID 22698913 DOI: 10.2337/Db11-1525  0.774
2012 Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC. Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms. The Journal of Biological Chemistry. 287: 25821-33. PMID 22685295 DOI: 10.1074/Jbc.M112.361501  0.686
2012 Kalwat MA, Wiseman DA, Luo W, Wang Z, Thurmond DC. Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis. Molecular Endocrinology (Baltimore, Md.). 26: 128-41. PMID 22108804 DOI: 10.1210/Me.2011-1112  0.721
2011 Kepner EM, Yoder SM, Oh E, Kalwat MA, Wang Z, Quilliam LA, Thurmond DC. Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion. American Journal of Physiology. Endocrinology and Metabolism. 301: E1072-80. PMID 21828338 DOI: 10.1152/Ajpendo.00312.2011  0.755
2011 Jewell JL, Oh E, Ramalingam L, Kalwat MA, Tagliabracci VS, Tackett L, Elmendorf JS, Thurmond DC. Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis. The Journal of Cell Biology. 193: 185-99. PMID 21444687 DOI: 10.1083/Jcb.201007176  0.788
2011 Wiseman DA, Kalwat MA, Thurmond DC. Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis. The Journal of Biological Chemistry. 286: 16344-54. PMID 21393240 DOI: 10.1074/Jbc.M110.214031  0.733
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