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F Peter Guengerich - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Biochemistry
Website:
https://medschool.vanderbilt.edu/biochemistry/person/f-peter-guengerich/
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Year Citation  Score
2023 Guengerich FP, McCarty KD, Tateishi Y, Liu L. Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1). Methods in Enzymology. 689: 39-63. PMID 37802581 DOI: 10.1016/bs.mie.2023.04.001  0.303
2023 Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T. Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical Research in Toxicology. PMID 37783573 DOI: 10.1021/acs.chemrestox.3c00229  0.537
2023 Lee SG, Kim V, Lee GH, Kim C, Jeong E, Guengerich FP, Kim D. Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1). Journal of Inorganic Biochemistry. 240: 112085. PMID 36640554 DOI: 10.1016/j.jinorgbio.2022.112085  0.498
2022 Chakraborty S, Mallick D, Goswami M, Guengerich FP, Chakrabarty A, Chowdhury G. The Natural Products Withaferin A and Withanone from the Medicinal Herb Are Covalent Inhibitors of the SARS-CoV-2 Main Protease. Journal of Natural Products. PMID 36098617 DOI: 10.1021/acs.jnatprod.2c00521  0.541
2022 Ghodke PP, Matse JH, Dawson S, Guengerich FP. Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA. Chemical Research in Toxicology. PMID 35482010 DOI: 10.1021/acs.chemrestox.2c00068  0.771
2022 Shimada T, Nagayoshi H, Murayama N, Sawai A, Kim V, Kim D, Yamazaki H, Guengerich FP, Takenaka S. Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 52: 134-145. PMID 35387543 DOI: 10.1080/00498254.2022.2062486  0.518
2021 Ghodke PP, Guengerich FP. DNA polymerases η and κ bypass N-guanine-O-alkylguanine DNA alkyltransferase crosslinked DNA-peptides. The Journal of Biological Chemistry. 101124. PMID 34461101 DOI: 10.1016/j.jbc.2021.101124  0.764
2021 Kim D, Kim V, Tateishi Y, Guengerich FP. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 34330716 DOI: 10.1124/dmd.121.000475  0.525
2021 Nagayoshi H, Murayama N, Takenaka S, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-47. PMID 34224301 DOI: 10.1080/00498254.2021.1950866  0.53
2021 Guengerich FP, Ghodke PP. Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society. 43: 24. PMID 34130743 DOI: 10.1186/s41021-021-00199-x  0.776
2021 Ghodke PP, Mali JR, Patra A, Rizzo CJ, Guengerich FP, Egli M. Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N-ethenodeoxyguanosine by human DNA translesion polymerase η. The Journal of Biological Chemistry. 100642. PMID 33839151 DOI: 10.1016/j.jbc.2021.100642  0.761
2021 Kim D, Kim V, McCarty KD, Guengerich FP. Tight binding of cytochrome b to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. The Journal of Biological Chemistry. 100571. PMID 33753170 DOI: 10.1016/j.jbc.2021.100571  0.501
2021 Ghodke PP, Gonzalez-Vasquez G, Wang H, Johnson KM, Sedgeman CA, Guengerich FP. Enzymatic bypass of an N-deoxyadenosine DNA-ethylene dibromide-peptide crosslink by translesion DNA polymerases. The Journal of Biological Chemistry. 100444. PMID 33617883 DOI: 10.1016/j.jbc.2021.100444  0.761
2021 Rendic SP, Guengerich FP. Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology. 95: 395-472. PMID 33459808 DOI: 10.1007/s00204-020-02971-4  0.301
2020 Shimada T, Nagayoshi H, Murayama N, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP. Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-55. PMID 33047997 DOI: 10.1080/00498254.2020.1836433  0.505
2020 Child SA, Reddish MJ, Glass SM, Goldfarb MH, Barckhausen IR, Guengerich FP. Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes. Archives of Biochemistry and Biophysics. 694: 108596. PMID 32980349 DOI: 10.1016/j.abb.2020.108596  0.305
2020 Ahmed N, Chakrabarty A, Guengerich FP, Chowdhury G. Protective Role of Glutathione Against Peroxynitrite-Mediated DNA Damage During Acute Inflammation. Chemical Research in Toxicology. PMID 32894672 DOI: 10.1021/Acs.Chemrestox.0C00299  0.606
2020 Guengerich FP. A history of the roles of cytochrome P450 enzymes in the toxicity of drugs. Toxicological Research. 1-23. PMID 32837681 DOI: 10.1007/S43188-020-00056-Z  0.308
2020 Yeom M, Hong JK, Kim JK, Guengerich FP, Choi JY. Three Human Pol Variants with Impaired Polymerase Activity Fail to Rescue HO Sensitivity in -Deficient Cells. Chemical Research in Toxicology. PMID 32635723 DOI: 10.1021/Acs.Chemrestox.0C00127  0.354
2020 Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI. A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis. The Journal of Biological Chemistry. PMID 32493730 DOI: 10.1074/Jbc.Ra120.014064  0.341
2020 Nagayoshi H, Murayama N, Tsujino M, Takenaka S, Katahira J, Kim V, Kim D, Komori M, Yamazaki H, Guengerich FP, Shimada T. Preference for -demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-42. PMID 32312164 DOI: 10.1080/00498254.2020.1759157  0.571
2020 Child SA, Guengerich FP. Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. Journal of Medicinal Chemistry. 63: 6513-6522. PMID 32223238 DOI: 10.1021/Acs.Jmedchem.9B01849  0.389
2020 Ghodke PP, Guengerich FP. Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair. Journal of Biological Chemistry. 295: 6092-6107. PMID 32213600 DOI: 10.1074/Jbc.Ra120.012829  0.772
2020 Guengerich FP. Cytochrome P450 2E1 and its roles in disease. Chemico-Biological Interactions. 322: 109056. PMID 32198084 DOI: 10.1016/J.Cbi.2020.109056  0.396
2020 Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA. In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. Journal of Medicinal Chemistry. 63: 6477-6488. PMID 31617715 DOI: 10.1021/Acs.Jmedchem.9B01383  0.39
2020 Guengerich FP, Fekry MI. Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition Acs Catalysis. 10: 5008-5022. DOI: 10.1021/Acscatal.0C00677  0.317
2019 Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W. Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. The Journal of Biological Chemistry. PMID 31811088 DOI: 10.1074/Jbc.Rev119.008758  0.373
2019 Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI. Validation of human sterol 14α-demethylase (CYP51) druggability: structure-guided design, synthesis and evaluation of stoichiometric, functionally irreversible inhibitors. Journal of Medicinal Chemistry. PMID 31663733 DOI: 10.1021/Acs.Jmedchem.9B01485  0.328
2019 Fekry MI, Xiao Y, Berg JZ, Guengerich FP. A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31511258 DOI: 10.1124/Dmd.119.089086  0.417
2019 Reddish MJ, Guengerich FP. Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone. Journal of Biological Chemistry. 294: 12975-12991. PMID 31296661 DOI: 10.1074/Jbc.Ra119.009830  0.407
2019 Guengerich FP, Wilkey CJ, Phan TTN. Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. The Journal of Biological Chemistry. PMID 31147443 DOI: 10.1074/Jbc.Ra119.009305  0.399
2019 Chattopadhyay M, Roy Chowdhury A, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani N. Mitochondria-targeted cytochrome P450 CYP2D6 is involved in monomethylamine-induced neuronal damage in mouse models. The Journal of Biological Chemistry. PMID 31113867 DOI: 10.1074/Jbc.Ra119.008848  0.305
2019 Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ. Conformational selection dominates binding of steroids to human cytochrome P450 17A1. The Journal of Biological Chemistry. PMID 31072872 DOI: 10.1074/Jbc.Ra119.008860  0.402
2019 Nagayoshi H, Murayama N, Kakimoto K, Tsujino M, Takenaka S, Katahira J, Lim YR, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology. PMID 30964977 DOI: 10.1021/Acs.Chemrestox.9B00078  0.59
2019 Albertolle ME, Glass SM, Trefts E, Guengerich FP. Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells. The Journal of Biological Chemistry. PMID 30850396 DOI: 10.1074/Jbc.Ac118.007225  0.308
2019 Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP. Human DNA polymerase has reverse transcriptase activity in cellular environments. The Journal of Biological Chemistry. PMID 30842261 DOI: 10.1074/Jbc.Ra119.007925  0.776
2019 Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP. Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1. Chemical Research in Toxicology. PMID 30701961 DOI: 10.1021/Acs.Chemrestox.8B00353  0.421
2019 Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP. Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks. Current Protocols in Nucleic Acid Chemistry. e74. PMID 30657645 DOI: 10.1002/Cpnc.74  0.783
2019 Guengerich FP. Cytochrome P450 research and The Journal of Biological Chemistry. Journal of Biological Chemistry. 294: 1671-1680. PMID 29871932 DOI: 10.1074/Jbc.Tm118.004144  0.37
2019 Murayama N, Guengerich FP, Yamazaki H. Cytochrome P450 3A enzyme-dependent thalidomide toxicity and inducibility in cultured human placental cells Drug Metabolism and Pharmacokinetics. 34. DOI: 10.1016/J.Dmpk.2018.09.107  0.384
2018 Guengerich FP. Mechanisms of Cytochrome P450-Catalyzed Oxidations Acs Catalysis. 8: 10964-10976. PMID 31105987 DOI: 10.1021/Acscatal.8B03401  0.425
2018 Rendic SP, Guengerich FP. Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits. Drug Metabolism Reviews. 50: 256-342. PMID 30717606 DOI: 10.1080/03602532.2018.1483401  0.392
2018 Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Bastaki M, Davidsen JM, Harman CL, McGowen M, Taylor SV. FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30481573 DOI: 10.1016/J.Fct.2018.11.052  0.385
2018 Friggeri L, Hargrove TY, Rachakonda G, Blobaum AL, Fisher P, de Oliveira GM, da Silva CF, Soeiro MNC, Nes WD, Lindsley CW, Villalta F, Guengerich FP, Lepesheva GI. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. Journal of Medicinal Chemistry. PMID 30451500 DOI: 10.1021/Acs.Jmedchem.8B01671  0.309
2018 Guengerich FP, Avadhani NG. Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens. Advances in Experimental Medicine and Biology. 1032: 15-35. PMID 30362088 DOI: 10.1007/978-3-319-98788-0_2  0.382
2018 Hargrove TY, Wawrzak Z, Fisher PM, Child SA, Nes WD, Guengerich FP, Waterman MR, Lepesheva GI. Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. The Journal of Biological Chemistry. PMID 30327430 DOI: 10.1074/Jbc.Ra118.005850  0.37
2018 Smith RL, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Guengerich FP, Rietjens IMCM, Bastaki M, Harman CL, McGowen MM, Taylor SV. The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research. 7: 618-646. PMID 30090611 DOI: 10.1039/C7Tx00254H  0.429
2018 Nagayoshi H, Murayama N, Kakimoto K, Takenaka S, Katahira J, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-51. PMID 30048196 DOI: 10.1080/00498254.2018.1505064  0.558
2018 Sausville LN, Gangadhariah M, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. The cytochrome P450 slow metabolizers CYP2C9*2 and CYP2C9*3 directly regulate tumorigenesis via reduced epoxyeicosatrienoic acid production. Cancer Research. PMID 30012669 DOI: 10.1158/0008-5472.Can-17-3977  0.344
2018 Albertolle ME, Guengerich FP. The relationships between cytochromes P450 and H2O2: Production, reaction, and inhibition. Journal of Inorganic Biochemistry. 186: 228-234. PMID 29990746 DOI: 10.1016/J.Jinorgbio.2018.05.014  0.411
2018 Guengerich FP, Yoshimoto FK. Formation and Cleavage of C-C Bonds by Enzymatic Oxidation-Reduction Reactions. Chemical Reviews. 118: 6573-6655. PMID 29932643 DOI: 10.1021/Acs.Chemrev.8B00031  0.36
2018 Albertolle M, Phan TTN, Pozzi A, Guengerich FP. Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metabolizing Enzymes as a Response to Redox Alteration. Molecular & Cellular Proteomics : McP. PMID 29374135 DOI: 10.1074/Mcp.Ra117.000382  0.441
2018 Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Davidsen JM, Harman CL, Taylor SV. Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 29355624 DOI: 10.1016/J.Fct.2018.01.021  0.363
2018 Kakimoto K, Murayama N, Takenaka S, Nagayoshi H, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T. Cytochrome P450 2A6 and Other Human P450 Enzymes in the Oxidation of Flavone and Flavanone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-49. PMID 29310511 DOI: 10.1080/00498254.2018.1426133  0.603
2018 Yamazaki H, Murayama N, Shimizu M, Guengerich FP. Induction of human cytochrome P450 3A enzymes in hepatic and placental cells by thalidomide and relevance to bioactivation Drug Metabolism and Pharmacokinetics. 33. DOI: 10.1016/J.Dmpk.2017.11.114  0.399
2017 Gonzalez E, Johnson KM, Pallan PS, Phan TTN, Zhang W, Lei LI, Wawrzak Z, Yoshimoto FK, Egli M, Guengerich FP. Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes. The Journal of Biological Chemistry. PMID 29212707 DOI: 10.1074/Jbc.Ra117.000504  0.4
2017 Su Y, Egli M, Guengerich FP. Human DNA polymerase η accommodates RNA for strand extension. The Journal of Biological Chemistry. PMID 28972162 DOI: 10.1074/Jbc.M117.809723  0.339
2017 Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G. The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. Chemical Research in Toxicology. PMID 28745489 DOI: 10.1021/Acs.Chemrestox.7B00127  0.64
2017 Johnson KM, Phan TTN, Albertolle ME, Guengerich FP. Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol. The Journal of Biological Chemistry. PMID 28701464 DOI: 10.1074/Jbc.M116.773937  0.385
2017 Gonzalez E, Guengerich FP. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. The Journal of Biological Chemistry. PMID 28684414 DOI: 10.1074/Jbc.M117.794917  0.407
2017 Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M. Oxidation of 1-Chloropyrene by Human CYP1 Family and CYP2A Subfamily Cytochrome P450 Enzymes: Catalytic Roles of Two CYP1B1 and Five CYP2A13 Allelic Variants. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-42. PMID 28648140 DOI: 10.1080/00498254.2017.1347306  0.58
2017 Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA. In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. The Journal of Biological Chemistry. PMID 28642370 DOI: 10.1074/Jbc.M117.794909  0.338
2017 Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP. Functional Analysis of Human Cytochrome P450 21A2 Variants Involved in Congenital Adrenal Hyperplasia. The Journal of Biological Chemistry. PMID 28539365 DOI: 10.1074/Jbc.M117.792465  0.421
2017 Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas U, Johnson EF, Guengerich FP. Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. The Journal of Biological Chemistry. PMID 28533430 DOI: 10.1074/Jbc.M117.792200  0.585
2017 Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H. Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. The Journal of Toxicological Sciences. 42: 343-348. PMID 28496040 DOI: 10.2131/Jts.42.343  0.416
2017 Sedgeman CA, Su Y, Guengerich FP. Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases. Chemical Research in Toxicology. PMID 28395138 DOI: 10.1021/Acs.Chemrestox.7B00022  0.378
2017 Marsch GA, Carlson BT, Guengerich FP. 7,8-Benzoflavone Binding to Human Cytochrome P450 3A4 Reveals Complex Fluorescence Quenching, Suggesting Binding at Multiple Protein Sites. Journal of Biomolecular Structure & Dynamics. 1-74. PMID 28278026 DOI: 10.1080/07391102.2017.1301270  0.375
2016 Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV. Safety evaluation of substituted thiophenes used as flavoring ingredients. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27836750 DOI: 10.1016/J.Fct.2016.10.023  0.408
2016 Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Taylor SV. FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27773699 DOI: 10.1016/J.Fct.2016.10.020  0.466
2016 Patra A, Zhang Q, Guengerich FP, Egli M. Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η. The Journal of Biological Chemistry. 291: 24304-24313. PMID 27694439 DOI: 10.1074/Jbc.M116.755462  0.353
2016 Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M. Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27625140 DOI: 10.1124/Dmd.116.072991  0.59
2016 Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Scharer OD, Sham YY, Tretyakova N. Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases. The Journal of Biological Chemistry. PMID 27621316 DOI: 10.1074/Jbc.M116.745257  0.368
2016 Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY. Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. Chemical Research in Toxicology. PMID 27603496 DOI: 10.1021/Acs.Chemrestox.6B00244  0.356
2016 Yoshimoto FK, Jung IJ, Goyal S, Guengerich FP, Gonzalez E. Isotope-Labeling Studies Support an Electrophilic Compound I Iron Active Species (FeO3+) for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side Chain Cleavage Enzyme, Cytochrome P450 11A1 (P450SCC). Journal of the American Chemical Society. PMID 27571509 DOI: 10.1021/Jacs.6B04437  0.354
2016 Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong HL, Guengerich FP, Liebler DC. Specificity of protein covalent modification by the electrophilic proteasome inhibitor carfilzomib in human cells. Molecular & Cellular Proteomics : McP. PMID 27503896 DOI: 10.1074/Mcp.M116.059709  0.324
2016 Guengerich FP. Intersection of Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates. Relevance to Toxicity and Drug Interactions. Chemical Research in Toxicology. PMID 27472660 DOI: 10.1021/Acs.Chemrestox.6B00226  0.413
2016 Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP. Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-chromosome or Hepatocytes by Two-dimensional Electrophoresis/Accelerator Mass Spectrometry. Chemical Research in Toxicology. PMID 27464947 DOI: 10.1021/Acs.Chemrestox.6B00210  0.388
2016 Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP. Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1. 18O-Labeling and Oxygen Surrogate Evidence for a Role of a Perferryl Oxygen. The Journal of Biological Chemistry. PMID 27339894 DOI: 10.1074/Jbc.M116.732966  0.365
2016 Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP. Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, And Physiologically-Based Pharmacokinetic Modeling in Toxicology. Chemical Research in Toxicology. PMID 27337115 DOI: 10.1021/Acs.Chemrestox.6B00136  0.347
2016 Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D. Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. Scientific Reports. 6: 28462. PMID 27334049 DOI: 10.1038/Srep28462  0.323
2016 Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI. Human sterol 14α-demethylase (CYP51) as a target for anticancer chemotherapy: Towards structure-aided drug design. Journal of Lipid Research. PMID 27313059 DOI: 10.1194/Jlr.M069229  0.316
2016 Savas U, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. 20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor. The Journal of Biological Chemistry. PMID 27298316 DOI: 10.1074/Jbc.M116.732297  0.322
2016 Guengerich FP, Waterman MR, Egli M. Recent Structural Insights into Cytochrome P450 Function. Trends in Pharmacological Sciences. PMID 27267697 DOI: 10.1016/J.Tips.2016.05.006  0.363
2016 Liu B, Xue Q, Tang Y, Cao J, Guengerich FP, Zhang H. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Mutation Research. Reviews in Mutation Research. 768: 53-67. PMID 27234563 DOI: 10.1016/J.Mrrev.2016.03.006  0.348
2016 Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M. Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. The Journal of Biological Chemistry. PMID 27226627 DOI: 10.1074/Jbc.M116.732487  0.365
2016 Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and their Alkynyl Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. PMID 27137136 DOI: 10.1021/Acs.Chemrestox.6B00083  0.55
2016 Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chemical Research in Toxicology. PMID 26914252 DOI: 10.1021/Acs.Chemrestox.5B00513  0.351
2016 Su Y, Egli M, Guengerich FP. Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. The Journal of Biological Chemistry. PMID 26740629 DOI: 10.1074/Jbc.M115.706226  0.354
2015 Xue Q, Zhong M, Liu B, Tang Y, Wei Z, Guengerich FP, Zhang H. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. Biochimie. PMID 26700143 DOI: 10.1016/J.Biochi.2015.12.009  0.381
2015 O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ. Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. Biochemistry. 54: 7449-56. PMID 26624500 DOI: 10.1021/Acs.Biochem.5B01078  0.376
2015 Hargrove TY, Wawrzak Z, Lamb DC, Guengerich FP, Lepesheva GI. Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs. The Journal of Biological Chemistry. 290: 23916-34. PMID 26269599 DOI: 10.1074/Jbc.M115.677310  0.355
2015 Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-14. PMID 26247835 DOI: 10.3109/00498254.2015.1069419  0.591
2015 Pallan PS, Lei L, Wang C, Waterman MR, Guengerich FP, Egli M. Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia. Molecular Endocrinology (Baltimore, Md.). 29: 1375-84. PMID 26172259 DOI: 10.1210/Me.2015-1127  0.365
2015 Kramlinger VM, Alvarado Rojas M, Kanamori T, Guengerich FP. Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis. The Journal of Biological Chemistry. 290: 20200-10. PMID 26157146 DOI: 10.1074/Jbc.M115.665331  0.368
2015 Guengerich FP. Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases. The Journal of Biological Chemistry. 290: 20700-1. PMID 26152720 DOI: 10.1074/Jbc.R115.675652  0.336
2015 Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY. Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Chemical Research in Toxicology. 28: 1496-507. PMID 26098310 DOI: 10.1021/Acs.Chemrestox.5B00166  0.314
2015 Su Y, Patra A, Harp JM, Egli M, Guengerich FP. Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. The Journal of Biological Chemistry. 290: 15921-33. PMID 25947374 DOI: 10.1074/Jbc.M115.653691  0.349
2015 Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. The Journal of Biological Chemistry. 290: 13128-43. PMID 25855791 DOI: 10.1074/Jbc.M115.646307  0.417
2015 Boji? M, Sedgeman CA, Nagy LD, Guengerich FP. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 73: 49-56. PMID 25840124 DOI: 10.1016/J.Ejps.2015.03.015  0.385
2015 Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, et al. Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo. Nucleic Acids Research. 43: 5489-500. PMID 25837992 DOI: 10.1093/Nar/Gkv243  0.305
2015 Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B. Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Dna Repair. 30: 1-10. PMID 25797601 DOI: 10.1016/J.Dnarep.2015.02.021  0.387
2015 Chowdhury G, Guengerich FP. Characterization of thioether-linked protein adducts of DNA using a raney-ni-mediated desulfurization method and liquid chromatography-electrospray-tandem mass spectrometry. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 60: 10.15.1-10.15.14. PMID 25754888 DOI: 10.1002/0471142700.Nc1015S60  0.614
2015 Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP. Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. The Journal of Biological Chemistry. 290: 8028-38. PMID 25666608 DOI: 10.1074/Jbc.M115.637561  0.347
2015 Shimada T, Takenaka S, Murayama N, Yamazaki H, Kim JH, Kim D, Yoshimoto FK, Guengerich FP, Komori M. Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology. PMID 25642975 DOI: 10.1021/Tx500505Y  0.569
2015 Lajovic A, Nagy LD, Guengerich FP, Bren U. Carcinogenesis of urethane: simulation versus experiment. Chemical Research in Toxicology. 28: 691-701. PMID 25642734 DOI: 10.1021/Tx500459T  0.327
2015 Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. The Journal of Biological Chemistry. 290: 3248-68. PMID 25533464 DOI: 10.1074/Jbc.M114.627265  0.407
2015 Rendic S, Guengerich FP. Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. Chemical Research in Toxicology. 28: 38-42. PMID 25485457 DOI: 10.1021/Tx500444E  0.43
2015 Guengerich FP, Zhao L, Pence MG, Egli M. Structure and function of the translesion DNA polymerases and interactions with damaged DNA Perspectives in Science. 4: 24-31. DOI: 10.1016/J.Pisc.2014.12.005  0.363
2015 Guengerich FP. Human cytochrome P450 enzymes Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition. 523-785. DOI: 10.1007/978-3-319-12108-6_9  0.305
2014 O'Flaherty DK, Guengerich FP. Steady-state kinetic analysis of DNA polymerase single-nucleotide incorporation products. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 59: 7.21.1-7.21.13. PMID 25501593 DOI: 10.1002/0471142700.Nc0721S59  0.35
2014 Yoshimoto FK, Guengerich FP. Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Journal of the American Chemical Society. 136: 15016-25. PMID 25252141 DOI: 10.1021/Ja508185D  0.365
2014 Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 53: 6161-72. PMID 25203493 DOI: 10.1021/Bi500710E  0.581
2014 Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chemical Research in Toxicology. 27: 1837-52. PMID 25162224 DOI: 10.1021/Tx5002755  0.365
2014 Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. The Journal of Biological Chemistry. 289: 29614-30. PMID 25160618 DOI: 10.1074/Jbc.M114.583062  0.321
2014 Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. The Febs Journal. 281: 4394-410. PMID 25065501 DOI: 10.1111/Febs.12947  0.34
2014 Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. Journal of Lipid Research. 55: 1933-43. PMID 25017465 DOI: 10.1194/Jlr.M051508  0.406
2014 Bojić M, Barbero L, Dolgos H, Freisleben A, Gallemann D, Riva S, Guengerich FP. Time- and NADPH-dependent inhibition of cytochrome P450 3A4 by the cyclopentapeptide cilengitide: significance of the guanidine group and accompanying spectral changes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1438-46. PMID 24985702 DOI: 10.1124/Dmd.114.059295  0.413
2014 Song I, Kim EJ, Kim IH, Park EM, Lee KE, Shin JH, Guengerich FP, Choi JY. Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. Chemical Research in Toxicology. 27: 919-30. PMID 24725253 DOI: 10.1021/Tx500072M  0.369
2014 Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S, Guengerich FP. Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. The Journal of Biological Chemistry. 289: 10476-87. PMID 24563460 DOI: 10.1074/Jbc.M114.550004  0.396
2014 Murayama N, van Beuningen R, Suemizu H, Guguen-Guillouzo C, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H. Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chemical Research in Toxicology. 27: 304-8. PMID 24460184 DOI: 10.1021/Tx4004374  0.387
2014 Chowdhury G, Shibata N, Yamazaki H, Guengerich FP. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. Chemical Research in Toxicology. 27: 147-56. PMID 24350712 DOI: 10.1021/Tx4004215  0.672
2014 Guengerich FP. Cytochrome P450 Enzymes Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.01960-7  0.315
2013 Guengerich FP. Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions. Journal of Labelled Compounds & Radiopharmaceuticals. 56: 428-31. PMID 24285515 DOI: 10.1002/Jlcr.3031  0.402
2013 Cho SH, Guengerich FP. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. Chemical Research in Toxicology. 26: 1765-74. PMID 24191644 DOI: 10.1021/Tx4003534  0.358
2013 Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Biochemistry. 52: 8766-76. PMID 24171480 DOI: 10.1021/Bi401103K  0.379
2013 Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE. Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. Biochemistry. 52: 8276-85. PMID 24138531 DOI: 10.1021/Bi401208M  0.343
2013 Chowdhury G, Cho SH, Pegg AE, Guengerich FP. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Angewandte Chemie (International Ed. in English). 52: 12879-82. PMID 24130045 DOI: 10.1002/Anie.201307580  0.634
2013 Stornetta A, Angelov T, Guengerich FP, Sturla SJ. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Chembiochem : a European Journal of Chemical Biology. 14: 1634-9. PMID 23959784 DOI: 10.1002/Cbic.201300296  0.348
2013 Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochemical Pharmacology. 86: 548-60. PMID 23792120 DOI: 10.1016/J.Bcp.2013.06.006  0.35
2013 Cho SH, Guengerich FP. Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases. Chemical Research in Toxicology. 26: 1005-13. PMID 23701509 DOI: 10.1021/Tx400145E  0.378
2013 Wang K, Guengerich FP. Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1. Chemical Research in Toxicology. 26: 993-1004. PMID 23682735 DOI: 10.1021/Tx400139P  0.428
2013 Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. The Journal of Toxicological Sciences. 38: 349-54. PMID 23665933 DOI: 10.2131/Jts.38.349  0.342
2013 Guengerich FP, Munro AW. Unusual cytochrome p450 enzymes and reactions. The Journal of Biological Chemistry. 288: 17065-73. PMID 23632016 DOI: 10.1074/Jbc.R113.462275  0.402
2013 Guengerich FP. New trends in cytochrome p450 research at the half-century mark. The Journal of Biological Chemistry. 288: 17063-4. PMID 23632015 DOI: 10.1074/Jbc.R113.466821  0.387
2013 Akiyoshi T, Ito M, Murase S, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. Drug Metabolism and Pharmacokinetics. 28: 411-5. PMID 23514827 DOI: 10.2133/Dmpk.Dmpk-12-Rg-134  0.355
2013 Cheng Q, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Methods in Molecular Biology (Clifton, N.J.). 987: 157-62. PMID 23475676 DOI: 10.1007/978-1-62703-321-3_14  0.381
2013 Cheng Q, Guengerich FP. Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches. Methods in Molecular Biology (Clifton, N.J.). 987: 71-7. PMID 23475668 DOI: 10.1007/978-1-62703-321-3_6  0.352
2013 Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP. Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. 26: 529-37. PMID 23432465 DOI: 10.1021/Tx3004906  0.586
2013 Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Chemical Research in Toxicology. 26: 517-28. PMID 23432429 DOI: 10.1021/Tx300492J  0.568
2013 Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. Chemical Research in Toxicology. 26: 486-9. PMID 23419139 DOI: 10.1021/Tx400008G  0.378
2013 Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP. Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. Archives of Biochemistry and Biophysics. 530: 101-7. PMID 23357279 DOI: 10.1016/J.Abb.2013.01.001  0.404
2013 Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. The Journal of Biological Chemistry. 288: 4436-51. PMID 23258538 DOI: 10.1074/Jbc.M112.402123  0.596
2012 Chowdhury G, Calcutt MW, Nagy LD, Guengerich FP. Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Biochemistry. 51: 9995-10007. PMID 23186213 DOI: 10.1021/Bi301092C  0.659
2012 Kotapati S, Maddukuri L, Wickramaratne S, Seneviratne U, Goggin M, Pence MG, Villalta P, Guengerich FP, Marnett L, Tretyakova N. Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. The Journal of Biological Chemistry. 287: 38800-11. PMID 22977231 DOI: 10.1074/Jbc.M112.396788  0.346
2012 Zhao L, Pence MG, Christov PP, Wawrzak Z, Choi JY, Rizzo CJ, Egli M, Guengerich FP. Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases. The Journal of Biological Chemistry. 287: 35516-26. PMID 22910910 DOI: 10.1074/Jbc.M112.403253  0.334
2012 Lim S, Song I, Guengerich FP, Choi JY. Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). Chemical Research in Toxicology. 25: 1699-707. PMID 22793782 DOI: 10.1021/Tx300168P  0.34
2012 Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP. Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. The Journal of Biological Chemistry. 287: 29554-67. PMID 22773874 DOI: 10.1074/Jbc.M112.390047  0.747
2012 Wang K, Guengerich FP. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. Chemical Research in Toxicology. 25: 1740-51. PMID 22734839 DOI: 10.1021/Tx3001994  0.411
2012 Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chemical Research in Toxicology. 25: 1652-61. PMID 22721435 DOI: 10.1021/Tx300113E  0.341
2012 Cho SH, Guengerich FP. Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. Chemical Research in Toxicology. 25: 1522-30. PMID 22670845 DOI: 10.1021/Tx3002109  0.4
2012 Xiao Y, Guengerich FP. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. Journal of Lipid Research. 53: 1610-7. PMID 22591743 DOI: 10.1194/Jlr.M027185  0.413
2012 Rendic S, Guengerich FP. Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. Current Drug Metabolism. 13: 787-814. PMID 22571481 DOI: 10.2174/138920012800840356  0.347
2012 Rendic S, Guengerich FP. Contributions of human enzymes in carcinogen metabolism. Chemical Research in Toxicology. 25: 1316-83. PMID 22531028 DOI: 10.1021/Tx300132K  0.418
2012 Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP. Replication of N2,3-ethenoguanine by DNA polymerases. Angewandte Chemie (International Ed. in English). 51: 5466-9. PMID 22488769 DOI: 10.1002/Anie.201109004  0.368
2012 Guengerich FP. Introduction: use of radioactive compounds in drug discovery and development. Chemical Research in Toxicology. 25: 511-2. PMID 22324508 DOI: 10.1021/Tx3000522  0.321
2012 Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Chemical Research in Toxicology. 25: 274-6. PMID 22268628 DOI: 10.1021/Tx300009J  0.595
2012 Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR. Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. The Journal of Biological Chemistry. 287: 10613-22. PMID 22262854 DOI: 10.1074/Jbc.M111.323501  0.358
2012 Cho SH, Guengerich FP. Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. Chemical Research in Toxicology. 25: 706-12. PMID 22181695 DOI: 10.1021/Tx200471X  0.395
2012 Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 34: 66-74. PMID 21638641 DOI: 10.1002/bmb.2006.49403402066  0.718
2011 Chowdhury G, Guengerich FP. Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 7.16.1-11. PMID 22147421 DOI: 10.1002/0471142700.Nc0716S47  0.614
2011 Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. The Journal of Biological Chemistry. 286: 33021-8. PMID 21813643 DOI: 10.1074/Jbc.M111.282434  0.428
2011 Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. The Journal of Biological Chemistry. 286: 31180-93. PMID 21784862 DOI: 10.1074/Jbc.M111.258038  0.375
2011 Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA. Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. Chemical Research in Toxicology. 24: 1223-30. PMID 21766881 DOI: 10.1021/Tx200080B  0.464
2011 Guengerich FP, Cheng Q. Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology. Pharmacological Reviews. 63: 684-99. PMID 21737533 DOI: 10.1124/Pr.110.003525  0.408
2011 Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M. Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. Chemical Research in Toxicology. 24: 1327-37. PMID 21732699 DOI: 10.1021/Tx200218U  0.383
2011 Salamanca-Pinzón SG, Guengerich FP. A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli. Protein Expression and Purification. 79: 231-6. PMID 21621619 DOI: 10.1016/J.Pep.2011.05.008  0.389
2011 Shinkyo R, Guengerich FP. Inhibition of human cytochrome P450 3A4 by cholesterol. The Journal of Biological Chemistry. 286: 18426-33. PMID 21471209 DOI: 10.1074/Jbc.M111.240457  0.386
2011 Xiao Y, Shinkyo R, Guengerich FP. Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 944-6. PMID 21430234 DOI: 10.1124/Dmd.111.039321  0.395
2011 Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chemical Research in Toxicology. 24: 287-9. PMID 21299192 DOI: 10.1021/Tx200005G  0.588
2011 Akiyoshi T, Saito T, Murase S, Miyazaki M, Murayama N, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 724-8. PMID 21212239 DOI: 10.1124/Dmd.110.036780  0.302
2011 Shinkyo R, Guengerich FP. Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction. The Journal of Biological Chemistry. 286: 4632-43. PMID 21147774 DOI: 10.1074/Jbc.M110.193409  0.398
2011 Guengerich FP, Sohl CD, Chowdhury G. Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Archives of Biochemistry and Biophysics. 507: 126-34. PMID 20804723 DOI: 10.1016/J.Abb.2010.08.017  0.806
2011 Guengerich FP, Tang Z, Cheng Q, Salamanca-Pinzón SG. Approaches to deorphanization of human and microbial cytochrome P450 enzymes Biochimica Et Biophysica Acta. 1814: 139-145. PMID 20493973 DOI: 10.1016/J.Bbapap.2010.05.005  0.391
2011 Zhang H, Bren U, Kozekov ID, Rizzo CJ, Stec DF, Guengerich FP. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases F1000research. 2. DOI: 10.7490/F1000Research.864.1  0.331
2010 Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chemical Research in Toxicology. 23: 1921-35. PMID 21053930 DOI: 10.1021/Tx100286D  0.395
2010 Cheng Q, Lamb DC, Kelly SL, Lei L, Guengerich FP. Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction. Journal of the American Chemical Society. 132: 15173-5. PMID 20979426 DOI: 10.1021/Ja107801V  0.403
2010 Eoff RL, Choi JY, Guengerich FP. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Journal of Nucleic Acids. 2010. PMID 20936119 DOI: 10.4061/2010/830473  0.349
2010 Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. Journal of Molecular Biology. 404: 34-44. PMID 20888339 DOI: 10.1016/J.Jmb.2010.09.015  0.301
2010 Cho SH, Loecken EM, Guengerich FP. Mutagenicity of a glutathione conjugate of butadiene diepoxide. Chemical Research in Toxicology. 23: 1544-6. PMID 20879737 DOI: 10.1021/Tx100304F  0.768
2010 Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1013-8. PMID 20823515 DOI: 10.1107/S1744309110029374  0.337
2010 Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angewandte Chemie (International Ed. in English). 49: 7481-5. PMID 20814997 DOI: 10.1002/Anie.201003168  0.367
2010 Tang Z, Guengerich FP. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Analytical Chemistry. 82: 7706-12. PMID 20795636 DOI: 10.1021/Ac1015497  0.303
2010 Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 49: 8415-24. PMID 20726503 DOI: 10.1021/Bi1009024  0.325
2010 Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ. Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chemical Research in Toxicology. 23: 1330-41. PMID 20578729 DOI: 10.1021/Tx100082E  0.331
2010 Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, et al. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research. 20: 1020-36. PMID 20538623 DOI: 10.1101/Gr.103341.109  0.392
2010 Chowdhury G, Murayama N, Okada Y, Uno Y, Shimizu M, Shibata N, Guengerich FP, Yamazaki H. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. Chemical Research in Toxicology. 23: 1018-24. PMID 20443640 DOI: 10.1021/Tx900367P  0.655
2010 Sohl CD, Guengerich FP. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. The Journal of Biological Chemistry. 285: 17734-43. PMID 20385561 DOI: 10.1074/Jbc.M110.123711  0.738
2010 Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Chemical Research in Toxicology. 23: 1076-88. PMID 20377178 DOI: 10.1021/Tx100053N  0.651
2010 Robert C, Wilson CS, Guengerich FP, Arreto CD. Evolution of the scientific literature of cytochrome P450 from 1977 to 2008. Current Drug Metabolism. 11: 162-70. PMID 20359288 DOI: 10.2174/138920010791110845  0.313
2010 Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion. Biochemistry. 49: 2615-26. PMID 20201499 DOI: 10.1021/Bi901516D  0.312
2010 Chowdhury G, Calcutt MW, Guengerich FP. Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps. The Journal of Biological Chemistry. 285: 8031-44. PMID 20061389 DOI: 10.1074/Jbc.M109.088039  0.664
2010 Zhang H, Guengerich FP. Effect of N2-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W Journal of Molecular Biology. 395: 1007-1018. PMID 19969000 DOI: 10.1016/J.Jmb.2009.11.071  0.38
2010 Sangar MC, Anandatheerthavarada HK, Martin MV, Guengerich FP, Avadhani NG. Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting. Molecular Genetics and Metabolism. 99: 90-7. PMID 19781968 DOI: 10.1016/J.Ymgme.2009.08.009  0.32
2009 Guengerich FP. Cataloging the Repertoire of Nature's Blowtorch, P450 Chemistry and Biology. 16: 1215-1216. PMID 20064429 DOI: 10.1016/J.Chembiol.2009.12.002  0.349
2009 Tang Z, Salamanca-Pinzón SG, Wu ZL, Xiao Y, Guengerich FP. Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. Archives of Biochemistry and Biophysics. 494: 86-93. PMID 19932081 DOI: 10.1016/J.Abb.2009.11.017  0.385
2009 Nguyen LP, Hsu EL, Chowdhury G, Dostalek M, Guengerich FP, Bradfield CA. D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Chemical Research in Toxicology. 22: 1897-904. PMID 19860415 DOI: 10.1021/Tx900043S  0.602
2009 Chowdhury G, Dostalek M, Hsu EL, Nguyen LP, Stec DF, Bradfield CA, Guengerich FP. Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. Chemical Research in Toxicology. 22: 1905-12. PMID 19860413 DOI: 10.1021/Tx9000418  0.599
2009 Zhang H, Beckman JW, Guengerich FP. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation Journal of Biological Chemistry. 284: 35144-35153. PMID 19837980 DOI: 10.1074/Jbc.M109.067397  0.378
2009 Deweese JE, Guengerich FP, Burgin AB, Osheroff N. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry. 48: 8940-7. PMID 19697956 DOI: 10.1021/Bi900875C  0.304
2009 Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nature Protocols. 4: 1258-61. PMID 19661996 DOI: 10.1038/Nprot.2009.123  0.742
2009 Sohl CD, Cheng Q, Guengerich FP. Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Nature Protocols. 4: 1252-7. PMID 19661995 DOI: 10.1038/Nprot.2009.122  0.745
2009 Guengerich FP, Martin MV, Sohl CD, Cheng Q. Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Nature Protocols. 4: 1245-51. PMID 19661994 DOI: 10.1038/Nprot.2009.121  0.737
2009 Zhang H, Bren U, Kozekov ID, Rizzo CJ, Stec DF, Guengerich FP. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Journal of Molecular Biology. 392: 251-69. PMID 19607842 DOI: 10.1016/J.Jmb.2009.07.019  0.361
2009 Nagashima S, Shimizu M, Yano H, Murayama N, Kumai T, Kobayashi S, Guengerich FP, Yamazaki H. Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors Drug Metabolism and Pharmacokinetics. 24: 218-225. PMID 19571433 DOI: 10.2133/Dmpk.24.218  0.314
2009 Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chemical Research in Toxicology. 22: 1325-1333. PMID 19563207 DOI: 10.1021/Tx900127S  0.372
2009 Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP. Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis Journal of Biological Chemistry. 284: 24425-24431. PMID 19561069 DOI: 10.1074/Jbc.M109.011320  0.404
2009 Wu ZL, Qiao J, Zhang ZG, Guengerich FP, Liu Y, Pei XQ. Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression. Biotechnology Letters. 31: 1589-93. PMID 19557307 DOI: 10.1007/S10529-009-0059-5  0.364
2009 Irimia A, Eoff RL, Guengerich FP, Egli M. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. The Journal of Biological Chemistry. 284: 22467-80. PMID 19542228 DOI: 10.1074/Jbc.M109.003905  0.363
2009 Eoff RL, Sanchez-Ponce R, Guengerich FP. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 284: 21090-9. PMID 19515847 DOI: 10.1074/Jbc.M109.009506  0.309
2009 Chowdhury G, Guengerich FP. Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. Chemical Research in Toxicology. 22: 1310-9. PMID 19496605 DOI: 10.1021/Tx900115Z  0.622
2009 Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 48: 7079-88. PMID 19492857 DOI: 10.1021/Bi9003588  0.385
2009 Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek M, Guengerich FP, Avadhani NG. Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism. The Febs Journal. 276: 3440-53. PMID 19438707 DOI: 10.1111/J.1742-4658.2009.07067.X  0.331
2009 Christov PP, Angel KC, Guengerich FP, Rizzo CJ. Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Chemical Research in Toxicology. 22: 1086-95. PMID 19397282 DOI: 10.1021/Tx900047C  0.334
2009 Choi JY, Lim S, Eoff RL, Guengerich FP. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Journal of Molecular Biology. 389: 264-74. PMID 19376129 DOI: 10.1016/J.Jmb.2009.04.023  0.352
2009 Loecken EM, Dasari S, Hill S, Tabb DL, Guengerich FP. The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. Chemical Research in Toxicology. 22: 1069-76. PMID 19364102 DOI: 10.1021/Tx900037U  0.785
2009 Tang Z, Martin MV, Guengerich FP. Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. Analytical Chemistry. 81: 3071-8. PMID 19301915 DOI: 10.1021/Ac900021A  0.422
2009 Brown KL, Bren U, Stone MP, Guengerich FP. Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis. Chemical Research in Toxicology. 22: 913-7. PMID 19301826 DOI: 10.1021/Tx900002G  0.36
2009 Knutson CG, Rubinson EH, Akingbade D, Anderson CS, Stec DF, Petrova KV, Kozekov ID, Guengerich FP, Rizzo CJ, Marnett LJ. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Biochemistry. 48: 800-9. PMID 19132922 DOI: 10.1021/Bi801654J  0.366
2009 Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Biochemistry. 48: 471-80. PMID 19108641 DOI: 10.1021/Bi801591A  0.338
2009 Zhang Z, Liu Y, Guengerich FP, Matse JH, Chen J, Wu Z. Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries Journal of Biotechnology. 139: 12-18. PMID 18984015 DOI: 10.1016/J.Jbiotec.2008.09.010  0.394
2009 Okada Y, Murayama N, Yanagida C, Shimizu M, Guengerich FP, Yamazaki H. Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5. Drug Metabolism and Disposition. 37: 18-23. PMID 18948377 DOI: 10.1124/Dmd.108.024679  0.437
2008 Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Chemical Research in Toxicology. 21: 2313-23. PMID 19548353 DOI: 10.1021/Tx8002998  0.386
2008 Beckman JW, Wang Q, Guengerich FP. Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. The Journal of Biological Chemistry. 283: 36711-23. PMID 18984592 DOI: 10.1074/Jbc.M806785200  0.334
2008 Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 47: 10892-903. PMID 18803403 DOI: 10.1021/Bi8008664  0.64
2008 Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2. Chemical Research in Toxicology. 21: 1795-805. PMID 18693701 DOI: 10.1021/Tx8001466  0.326
2008 Miyazaki M, Nakamura K, Fujita Y, Guengerich FP, Horiuchi R, Yamamoto K. Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone Drug Metabolism and Disposition. 36: 2287-2291. PMID 18669585 DOI: 10.1124/Dmd.108.021816  0.376
2008 Isin EM, Guengerich FP. Substrate binding to cytochromes P450 Analytical and Bioanalytical Chemistry. 392: 1019-1030. PMID 18622598 DOI: 10.1007/S00216-008-2244-0  0.382
2008 Choi JY, Guengerich FP. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1 Journal of Biological Chemistry. 283: 23645-23655. PMID 18591245 DOI: 10.1074/Jbc.M801686200  0.373
2008 Stark K, Wu Z, Bartleson CJ, Guengerich FP. mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1 Drug Metabolism and Disposition. 36: 1930-1937. PMID 18541694 DOI: 10.1124/Dmd.108.022020  0.387
2008 Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. The Journal of Biological Chemistry. 283: 17147-57. PMID 18442974 DOI: 10.1074/Jbc.M802447200  0.366
2008 Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical Research in Toxicology. 21: 1134-42. PMID 18416522 DOI: 10.1021/Tx7004458  0.339
2008 Isin EM, Sohl CD, Eoff RL, Guengerich FP. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Archives of Biochemistry and Biophysics. 473: 69-75. PMID 18328798 DOI: 10.1016/J.Abb.2008.02.033  0.726
2008 Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. The Journal of Biological Chemistry. 283: 7293-308. PMID 18187423 DOI: 10.1074/Jbc.M709783200  0.748
2008 Loecken EM, Guengerich FP. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Chemical Research in Toxicology. 21: 453-8. PMID 18163542 DOI: 10.1021/Tx7003618  0.799
2008 Guengerich FP. Cytochrome P450 and chemical toxicology Chemical Research in Toxicology. 21: 70-83. PMID 18052394 DOI: 10.1021/Tx700079Z  0.387
2008 Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH. Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. Protein Expression and Purification. 57: 188-200. PMID 18032064 DOI: 10.1016/J.Pep.2007.10.010  0.529
2008 Chowdhury G, Guengerich FP. Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry Angewandte Chemie - International Edition. 47: 381-384. PMID 18022988 DOI: 10.1002/Anie.200703942  0.601
2008 Dimitri A, Goodenough AK, Guengerich FP, Broyde S, Scicchitano DA. Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. Journal of Molecular Biology. 375: 353-66. PMID 18022639 DOI: 10.1016/J.Jmb.2007.10.057  0.327
2007 Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 18: 504-12. PMID 18006294 DOI: 10.1016/J.Copbio.2007.09.010  0.304
2007 Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M. Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. The Journal of Biological Chemistry. 282: 36421-33. PMID 17951245 DOI: 10.1074/Jbc.M707267200  0.355
2007 Shanmugam G, Goodenough AK, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6. Chemical Research in Toxicology. 20: 1601-11. PMID 17941687 DOI: 10.1021/Tx7001788  0.324
2007 Guengerich FP. Mechanisms of cytochrome P450 substrate oxidation: MiniReview Journal of Biochemical and Molecular Toxicology. 21: 163-168. PMID 17936929 DOI: 10.1002/Jbt.20174  0.387
2007 Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Chemical Research in Toxicology. 20: 1594-600. PMID 17907789 DOI: 10.1021/Tx700125P  0.376
2007 Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Molecular Pharmacology. 72: 1419-24. PMID 17898314 DOI: 10.1124/Mol.107.040238  0.422
2007 Stark K, Guengerich FP. Characterization of orphan human cytochromes P450 Drug Metabolism Reviews. 39: 627-637. PMID 17786643 DOI: 10.1080/03602530701467708  0.409
2007 Amunom I, Stephens LJ, Tamasi V, Cai J, Pierce WM, Conklin DJ, Bhatnagar A, Srivastava S, Martin MV, Guengerich FP, Prough RA. Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Archives of Biochemistry and Biophysics. 464: 187-96. PMID 17599801 DOI: 10.1016/J.Abb.2007.05.019  0.398
2007 Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP. Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 282: 19831-43. PMID 17468100 DOI: 10.1074/Jbc.M702290200  0.306
2007 Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP. Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). The Journal of Biological Chemistry. 282: 17486-500. PMID 17446171 DOI: 10.1074/Jbc.M700863200  0.395
2007 Sanchez-Ponce R, Guengerich FP. Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes. Analytical Chemistry. 79: 3355-62. PMID 17408243 DOI: 10.1021/Ac0622781  0.317
2007 Eoff RL, Angel KC, Egli M, Guengerich FP. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. The Journal of Biological Chemistry. 282: 13573-84. PMID 17337730 DOI: 10.1074/Jbc.M700656200  0.337
2007 Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP. Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors. Chemical Research in Toxicology. 20: 489-496. PMID 17291012 DOI: 10.1021/Tx600299P  0.396
2007 Isin EM, Guengerich FP. Complex reactions catalyzed by cytochrome P450 enzymes Biochimica Et Biophysica Acta - General Subjects. 1770: 314-329. PMID 17239540 DOI: 10.1016/J.Bbagen.2006.07.003  0.394
2007 Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Chemical Research in Toxicology. 20: 155-63. PMID 17226938 DOI: 10.1021/Tx600257G  0.378
2007 Isin EM, Guengerich FP. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 Journal of Biological Chemistry. 282: 6863-6874. PMID 17200113 DOI: 10.1074/Jbc.M610346200  0.378
2007 Butler BF, Palamanda J, Nomeir AA, Guengerich FP, Furge LL. Inhibition of Human Cytochrome P450 2D6 by Schering 66712 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A670-A  0.716
2006 Stover JS, Chowdhury G, Zang H, Guengerich FP, Rizzo CJ. Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Chemical Research in Toxicology. 19: 1506-17. PMID 17112239 DOI: 10.1021/Tx0601455  0.624
2006 Oda Y, Totsuka Y, Wakabayashi K, Guengerich FP, Shimada T. Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. Mutagenesis. 21: 411-416. PMID 17067997 DOI: 10.1093/Mutage/Gel047  0.363
2006 Choi JY, Chowdhury G, Zang H, Angel KC, Vu CC, Peterson LA, Guengerich FP. Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. The Journal of Biological Chemistry. 281: 38244-56. PMID 17050527 DOI: 10.1074/Jbc.M608369200  0.61
2006 Guengerich FP. A malleable catalyst dominates the metabolism of drugs Proceedings of the National Academy of Sciences of the United States of America. 103: 13565-13566. PMID 16954196 DOI: 10.1073/Pnas.0606333103  0.353
2006 Watanabe K, Guengerich FP. Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Chemical Research in Toxicology. 19: 1091-1096. PMID 16918250 DOI: 10.1021/Tx060087N  0.338
2006 Lamb DC, Guengerich FP, Kelly SL, Waterman MR. Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery. Expert Opinion On Drug Metabolism & Toxicology. 2: 27-40. PMID 16863466 DOI: 10.1517/17425255.2.1.27  0.316
2006 Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP. Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. The Journal of Biological Chemistry. 281: 25297-306. PMID 16835218 DOI: 10.1074/Jbc.M605699200  0.619
2006 Choi JY, Zang H, Angel KC, Kozekov ID, Goodenough AK, Rizzo CJ, Guengerich FP. Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chemical Research in Toxicology. 19: 879-86. PMID 16780368 DOI: 10.1021/Tx060051V  0.34
2006 Zang H, Chowdhury G, Angel KC, Harris TM, Guengerich FP. Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. Chemical Research in Toxicology. 19: 859-67. PMID 16780366 DOI: 10.1021/Tx060056S  0.64
2006 Choi J, Angel KC, Guengerich FP. Translesion Synthesis across Bulky N2-Alkyl Guanine DNA Adducts by Human DNA Polymerase κ Journal of Biological Chemistry. 281: 21062-21072. PMID 16751196 DOI: 10.1074/Jbc.M602246200  0.39
2006 Bren U, Zupan M, Guengerich FP, Mavri J. Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine. Journal of Organic Chemistry. 71: 4078-4084. PMID 16709046 DOI: 10.1021/Jo060098L  0.304
2006 Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. The Febs Journal. 273: 2223-31. PMID 16649998 DOI: 10.1111/j.1742-4658.2006.05235.x  0.538
2006 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity Aaps Journal. 8. PMID 16584116 DOI: 10.1208/Aapsj080112  0.351
2006 Wu ZL, Sohl CD, Shimada T, Guengerich FP. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Molecular Pharmacology. 69: 2007-14. PMID 16551781 DOI: 10.1124/Mol.106.023648  0.751
2006 Choi J, Guengerich FP. Kinetic Evidence for Inefficient and Error-prone Bypass across Bulky N2-Guanine DNA Adducts by Human DNA Polymerase ι Journal of Biological Chemistry. 281: 12315-12324. PMID 16527824 DOI: 10.1074/Jbc.M600112200  0.305
2006 Shimada T, Guengerich FP. Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons Chemical Research in Toxicology. 19: 288-294. PMID 16485905 DOI: 10.1021/Tx050291V  0.387
2006 Isin EM, Guengerich FP. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 Journal of Biological Chemistry. 281: 9127-9136. PMID 16467307 DOI: 10.1074/Jbc.M511375200  0.366
2006 Guengerich FP. Interactions of carcinogen-bound DNA with individual DNA polymerases Chemical Reviews. 106: 420-452. PMID 16464013 DOI: 10.1021/Cr0404693  0.343
2006 Wu Z, Bartleson CJ, Ham AL, Guengerich FP. Heterologous expression, purification, and properties of human cytochrome P450 27C1. Archives of Biochemistry and Biophysics. 445: 138-146. PMID 16360114 DOI: 10.1016/J.Abb.2005.11.002  0.383
2006 Zang H, Irimia A, Choi JY, Angel KC, Loukachevitch LV, Egli M, Guengerich FP. Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 281: 2358-72. PMID 16306039 DOI: 10.1074/Jbc.M510889200  0.338
2006 Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction Biochemistry and Molecular Biology Education. 34: 66-74. DOI: 10.1002/Bmb.2006.49403402066  0.737
2005 Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Chemistry & Biodiversity. 2: 51-65. PMID 17191919 DOI: 10.1002/Cbdv.200490166  0.303
2005 Guengerich FP. Activation of alkyl halides by glutathione transferases Methods in Enzymology. 401: 342-353. PMID 16399396 DOI: 10.1016/S0076-6879(05)01021-9  0.372
2005 Josephy PD, Guengerich FP, Miners JO. "Phase I" and "Phase II" drug metabolism: Terminology that we should phase out? Drug Metabolism Reviews. 37: 575-580. PMID 16393885 DOI: 10.1080/03602530500251220  0.306
2005 Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ. Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. Chemical Research in Toxicology. 18: 1701-14. PMID 16300379 DOI: 10.1021/Tx050141K  0.382
2005 Zhao B, Guengerich FP, Voehler M, Waterman MR. Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. The Journal of Biological Chemistry. 280: 42188-97. PMID 16239228 DOI: 10.1074/Jbc.M509220200  0.344
2005 Wu ZL, Podust LM, Guengerich FP. Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis. The Journal of Biological Chemistry. 280: 41090-100. PMID 16215230 DOI: 10.1074/Jbc.M508182200  0.412
2005 Kim D, Wu ZL, Guengerich FP. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. The Journal of Biological Chemistry. 280: 40319-27. PMID 16207711 DOI: 10.1074/Jbc.M508171200  0.587
2005 Guengerich FP, Wu Z, Bartleson CJ. Function of human cytochrome P450s: characterization of the orphans. Biochemical and Biophysical Research Communications. 338: 465-469. PMID 16126164 DOI: 10.1016/J.Bbrc.2005.08.079  0.396
2005 Choi JY, Guengerich FP. Adduct size limits efficient and error-free bypass across bulky N 2-guanine DNA lesions by human DNA polymerase η Journal of Molecular Biology. 352: 72-90. PMID 16061253 DOI: 10.1016/J.Jmb.2005.06.079  0.321
2005 Guengerich FP. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase Archives of Biochemistry and Biophysics. 440: 204-211. PMID 16055078 DOI: 10.1016/J.Abb.2005.06.019  0.304
2005 Zang H, Fang Q, Pegg AE, Guengerich FP. Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 280: 30873-81. PMID 16000301 DOI: 10.1074/Jbc.M505283200  0.344
2005 Zang H, Goodenough AK, Choi JY, Irimia A, Loukachevitch LV, Kozekov ID, Angel KC, Rizzo CJ, Egli M, Guengerich FP. DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. The Journal of Biological Chemistry. 280: 29750-64. PMID 15965231 DOI: 10.1074/Jbc.M504756200  0.347
2005 Dueckershoff K, Unger M, Frank A, Gillam EMJ, Guengerich FP, Warzecha H. Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA. Febs Letters. 579: 2480-2484. PMID 15848192 DOI: 10.1016/J.Febslet.2005.02.082  0.34
2005 Kim D, Guengerich FP. Cytochrome P450 activation of arylamines and heterocyclic amines. Annual Review of Pharmacology and Toxicology. 45: 27-49. PMID 15822170 DOI: 10.1146/Annurev.Pharmtox.45.120403.100010  0.584
2005 VanderVeen LA, Druckova A, Riggins JN, Sorrells JL, Guengerich FP, Marnett LJ. Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct Biochemistry. 44: 5024-5033. PMID 15794640 DOI: 10.1021/Bi0472898  0.379
2005 Krauser JA, Guengerich FP. Cytochrome P450 3A4-catalyzed testosterone 6β-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps Journal of Biological Chemistry. 280: 19496-19506. PMID 15772082 DOI: 10.1074/Jbc.M501854200  0.352
2005 Vélez-Cruz R, Riggins JN, Daniels JS, Cai H, Guengerich FP, Marnett LJ, Osheroff N. Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells Biochemistry. 44: 3972-3981. PMID 15751973 DOI: 10.1021/Bi0478289  0.37
2005 Zang H, Harris TM, Guengerich FP. Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. Chemical Research in Toxicology. 18: 389-400. PMID 15720147 DOI: 10.1021/Tx049683C  0.361
2005 Shimada T, Mernaugh RL, Guengerich FP. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5 enzymes Archives of Biochemistry and Biophysics. 435: 207-216. PMID 15680923 DOI: 10.1016/J.Abb.2004.12.008  0.431
2005 Yun CH, Kim KH, Calcutt MW, Guengerich FP. Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. The Journal of Biological Chemistry. 280: 12279-91. PMID 15665333 DOI: 10.1074/Jbc.M411019200  0.434
2005 Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, et al. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. The Journal of Biological Chemistry. 280: 11599-607. PMID 15659395 DOI: 10.1074/Jbc.M410933200  0.387
2005 Guengerich FP. Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation Archives of Biochemistry and Biophysics. 433: 369-378. PMID 15581593 DOI: 10.1016/J.Abb.2004.07.035  0.387
2005 Zang H, Harris TM, Guengerich FP. Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 280: 1165-78. PMID 15533946 DOI: 10.1074/Jbc.M405996200  0.379
2004 Kim D, Guengerich FP. Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. Archives of Biochemistry and Biophysics. 432: 102-8. PMID 15519301 DOI: 10.1016/J.Abb.2004.09.001  0.587
2004 Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH. Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Toxicology Letters. 153: 239-46. PMID 15451555 DOI: 10.1016/J.Toxlet.2004.04.017  0.437
2004 Krauser JA, Voehler M, Tseng L, Schefer AB, Godejohann M, Guengerich FP. Testosterone 1β‐hydroxylation by human cytochrome P450 3A4 Febs Journal. 271: 3962-3969. PMID 15373842 DOI: 10.1111/J.1432-1033.2004.04339.X  0.349
2004 Guengerich FP, Krauser JA, Johnson WW. Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry. 43: 10775-10788. PMID 15311939 DOI: 10.1021/Bi0491393  0.408
2004 Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K. Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Chemical Research in Toxicology. 17: 1077-85. PMID 15310239 DOI: 10.1021/Tx049889D  0.333
2004 Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 17: 972-82. PMID 15257623 DOI: 10.1021/Tx049897U  0.368
2004 Guengerich FP. Cytochrome P450: What have we learned and what are the future issues? Drug Metabolism Reviews. 36: 159-197. PMID 15237850 DOI: 10.1081/Dmr-120033996  0.396
2004 Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L. Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry. 47: 3236-41. PMID 15163202 DOI: 10.1021/Jm030561B  0.361
2004 Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I. Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metabolism and Disposition. 32: 666-674. PMID 15155559 DOI: 10.1124/Dmd.32.6.666  0.385
2004 Kim D, Kadlubar FF, Teitel CH, Guengerich FP. Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines. Chemical Research in Toxicology. 17: 529-36. PMID 15089095 DOI: 10.1021/Tx034267Y  0.557
2004 Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A. Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes Molecular Pharmacology. 65: 934-943. PMID 15044623 DOI: 10.1124/Mol.65.4.934  0.366
2004 Choi JY, Guengerich FP. Analysis of the Effect of Bulk at N2-Alkylguanine DNA Adducts on Catalytic Efficiency and Fidelity of the Processive DNA Polymerases Bacteriophage T7 Exonuclease- and HIV-1 Reverse Transcriptase Journal of Biological Chemistry. 279: 19217-19229. PMID 14985330 DOI: 10.1074/Jbc.M313759200  0.328
2004 Kim D, Guengerich FP. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. Biochemistry. 43: 981-8. PMID 14744142 DOI: 10.1021/Bi035593F  0.582
2004 Marsch GA, Botta S, Martin MV, McCormick WA, Guengerich FP. Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes. Chemical Research in Toxicology. 17: 45-54. PMID 14727918 DOI: 10.1021/Tx034156Z  0.375
2004 Zhou H, Josephy PD, Kim D, Guengerich FP. Functional characterization of four allelic variants of human cytochrome P450 1A2. Archives of Biochemistry and Biophysics. 422: 23-30. PMID 14725854 DOI: 10.1016/J.Abb.2003.11.019  0.583
2004 Valadez JG, Guengerich FP. S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage Journal of Biological Chemistry. 279: 13435-13446. PMID 14715658 DOI: 10.1074/Jbc.M312358200  0.347
2004 Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 279: 4250-9. PMID 14645247 DOI: 10.1074/Jbc.M311105200  0.403
2003 Guengerich FP. Cytochromes P450, drugs, and diseases Mol Interv. 3: 194-204. PMID 14993447 DOI: 10.1124/Mi.3.4.194  0.309
2003 Guengerich FP, McCormick WA, Wheeler JB. Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Chemical Research in Toxicology. 16: 1493-9. PMID 14615977 DOI: 10.1021/Tx034157R  0.301
2003 Kiyotani K, Yamazaki H, Fujieda M, Iwano S, Matsumura K, Satarug S, Ujjin P, Shimada T, Guengerich FP, Parkinson A, Honda G, Nakagawa K, Ishizaki T, Kamataki T. Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). Pharmacogenetics. 13: 689-695. PMID 14583682 DOI: 10.1097/00008571-200311000-00005  0.317
2003 Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE. O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry. 42: 10965-70. PMID 12974631 DOI: 10.1021/Bi034937Z  0.381
2003 Guengerich FP, Hanna IH, Martin MV, Gillam EM. Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. Biochemistry. 42: 1245-53. PMID 12564927 DOI: 10.1021/Bi027085W  0.375
2003 Guengerich FP. Activation of dihaloalkanes by thiol-dependent mechanisms Journal of Biochemistry and Molecular Biology. 36: 20-27. PMID 12542971 DOI: 10.5483/Bmbrep.2003.36.1.020  0.348
2003 Yun CH, Lee HS, Lee HY, Yim SK, Kim KH, Kim E, Yea SS, Guengerich FP. Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin Toxicology Letters. 137: 143-150. PMID 12523956 DOI: 10.1016/S0378-4274(02)00397-1  0.412
2003 Guengerich FP. Cytochrome P450 oxidations in the generation of reactive electrophiles: Epoxidation and related reactions Archives of Biochemistry and Biophysics. 409: 59-71. PMID 12464245 DOI: 10.1016/S0003-9861(02)00415-0  0.378
2002 Bell-Parikh LC, Hosea NA, Martin MV, Guengerich FP. Purification of cytochrome P-450 enzymes. Current Protocols in Toxicology. Unit4.2. PMID 23045082 DOI: 10.1002/0471140856.tx0402s12  0.323
2002 Guengerich FP, Wheeler JB, Chun YJ, Kim D, Shimada T, Aryal P, Oda Y, Gillam EM. Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. Toxicology. 181: 261-4. PMID 12505322 DOI: 10.1016/S0300-483X(02)00293-7  0.578
2002 Kim D, Guengerich FP. Random mutagenesis by whole-plasmid PCR amplification. Methods in Molecular Biology (Clifton, N.J.). 192: 241-5. PMID 12494656 DOI: 10.1385/1-59259-177-9:241  0.474
2002 Guengerich FP. Rate-limiting steps in cytochorme P450 catalysis Biological Chemistry. 383: 1553-1564. PMID 12452431 DOI: 10.1515/BC.2002.175  0.313
2002 Turesky RJ, Guengerich FP, Guillouzo A, Langouët S. Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. Mutation Research. 506: 187-195. PMID 12351158 DOI: 10.1016/S0027-5107(02)00165-3  0.343
2002 Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Biochemistry. 41: 11025-34. PMID 12206675 DOI: 10.1021/Bi020341K  0.369
2002 Liu L, Pegg AE, Williams KM, Guengerich FP. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 277: 37920-8. PMID 12151404 DOI: 10.1074/Jbc.M205548200  0.405
2002 Guengerich FP. Cytochrome P450 enzymes in the generation of commercial products Nature Reviews Drug Discovery. 1: 359-366. PMID 12120411 DOI: 10.1038/Nrd792  0.37
2002 Guengerich FP, Miller GP, Hanna IH, Sato H, Martin MV. Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps. The Journal of Biological Chemistry. 277: 33711-9. PMID 12093814 DOI: 10.1074/Jbc.M205146200  0.357
2002 Guengerich FP, Voehler M, Williams KM, Deng Z, Harris TM. Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine. Chemical Research in Toxicology. 15: 793-8. PMID 12067246 DOI: 10.1021/Tx0200055  0.339
2002 Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM. Reaction of aflatoxin B(1) oxidation products with lysine. Chemical Research in Toxicology. 15: 780-92. PMID 12067245 DOI: 10.1021/Tx010156S  0.354
2002 Saparbaev M, Langouët S, Privezentzev CV, Guengerich FP, Cai H, Elder RH, Laval J. 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. The Journal of Biological Chemistry. 277: 26987-93. PMID 12016206 DOI: 10.1074/Jbc.M111100200  0.356
2002 Guengerich FP. Update information on human P450s Drug Metabolism Reviews. 34: 7-15. PMID 11996014 DOI: 10.1081/Dmr-120001386  0.317
2002 Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expression and Purification. 24: 329-337. PMID 11922748 DOI: 10.1006/Prep.2001.1578  0.379
2002 Gillam EMJ, Guengerich FP. Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology Iubmb Life. 52: 271-277. PMID 11895075 DOI: 10.1080/152165401317291110  0.398
2002 Ueng YF, Jan WC, Lin LC, Chen T, Guengerich FP, Chen CF. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metabolism and Disposition. 30: 349-353. PMID 11854157 DOI: 10.1124/Dmd.30.3.349  0.377
2002 Woodside AM, Guengerich FP. Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Biochemistry. 41: 1039-50. PMID 11790128 DOI: 10.1021/Bi011496F  0.794
2002 Woodside AM, Guengerich FP. Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Biochemistry. 41: 1027-38. PMID 11790127 DOI: 10.1021/Bi011495N  0.772
2002 Anzenbacher P, Anzenbacherová E, Zuber R, Soucek P, Guengerich FP, Myers MJ, Farkell DE, Howard KD, Kawalek JC. Pig and minipig cytochromes P450 (multiple letters) Drug Metabolism and Disposition. 30: 100-102. PMID 11776951 DOI: 10.1124/Dmd.30.1.100  0.397
2001 Langouët S, Welti DH, Kerriguy N, Fay LB, Guengerich FP, Guillouzo A, Turesky RJ. Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes. Advances in Experimental Medicine and Biology. 500: 459-462. PMID 11764981 DOI: 10.1007/978-1-4615-0667-6_69  0.353
2001 Soucek P, Zuber R, Anzenbacherová E, Anzenbacher P, Guengerich FP. Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs Bmc Pharmacology. 1: 11-11. PMID 11737866 DOI: 10.1186/1471-2210-1-11  0.401
2001 Chun YJ, Kim S, Kim D, Lee SK, Guengerich FP. A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Research. 61: 8164-70. PMID 11719446  0.519
2001 Nakamura K, Martin MV, Guengerich FP. Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. Archives of Biochemistry and Biophysics. 395: 25-31. PMID 11673862 DOI: 10.1006/Abbi.2001.2569  0.387
2001 Hanna IH, Kim M, Guengerich FP. Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Archives of Biochemistry and Biophysics. 393: 255-261. PMID 11556812 DOI: 10.1006/Abbi.2001.2510  0.399
2001 Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T. Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 497: 223-233. PMID 11525925 DOI: 10.1016/S1383-5718(01)00254-6  0.383
2001 Hanna IH, Krauser JA, Cai H, Kim MS, Guengerich FP. Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. The Journal of Biological Chemistry. 276: 39553-61. PMID 11509577 DOI: 10.1074/Jbc.M106841200  0.416
2001 Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1176-82. PMID 11502724  0.325
2001 Yamazaki H, Shimada T, Martin MV, Guengerich FP. Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. The Journal of Biological Chemistry. 276: 30885-91. PMID 11413149 DOI: 10.1074/Jbc.M105011200  0.359
2001 Guengerich FP. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Chemical Research in Toxicology. 14: 611-650. PMID 11409933 DOI: 10.1021/Tx0002583  0.381
2001 Guengerich FP. Forging the links between metabolism and carcinogenesis Mutation Research - Reviews in Mutation Research. 488: 195-209. PMID 11397649 DOI: 10.1016/S1383-5742(01)00059-X  0.381
2001 Oda Y, Aryal P, Terashita T, Gillam EM, Guengerich FP, Shimada T. Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutation Research. 492: 81-90. PMID 11377247 DOI: 10.1016/S1383-5718(01)00154-1  0.37
2001 Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis. 22: 943-50. PMID 11375903 DOI: 10.1093/Carcin/22.6.943  0.386
2001 Nakamura K, Hanna IH, Cai H, Nishimura Y, Williams KM, Guengerich FP. Coumarin substrates for cytochrome P450 2D6 fluorescence assays. Analytical Biochemistry. 292: 280-286. PMID 11355862 DOI: 10.1006/Abio.2001.5098  0.388
2001 Cai H, Guengerich FP. Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: Inactivation and sites of modification Chemical Research in Toxicology. 14: 451-458. PMID 11304134 DOI: 10.1021/tx0002280  0.31
2001 Yun CH, Miller GP, Guengerich FP. Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: Structure - Activity relationships and simulation of rate constants of individual steps in catalysis Biochemistry. 40: 4521-4530. PMID 11284709 DOI: 10.1021/bi002906n  0.309
2001 and HC, Guengerich FP. Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions. Chemical Research in Toxicology. 14: 54-61. PMID 11170508 DOI: 10.1021/Tx000185N  0.369
2001 Gautier J, Richoz J, Welti DH, Markovic J, Gremaud E, Guengerich FP, Turesky RJ. Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Chemical Research in Toxicology. 14: 34-45. PMID 11170506 DOI: 10.1021/tx000070j  0.366
2000 Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM. What makes P450s work? Searches for answers with known and new P450s. Drug Metabolism Reviews. 32: 267-81. PMID 11139129 DOI: 10.1081/Dmr-100102334  0.595
2000 Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T. Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 472: 129-138. PMID 11113705 DOI: 10.1016/S1383-5718(00)00138-8  0.391
2000 Einolf HJ, Guengerich FP. Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis. The Journal of Biological Chemistry. 276: 3764-71. PMID 11110788 DOI: 10.1074/Jbc.M006696200  0.323
2000 Gillam EM, Notley LM, Cai H, De Voss JJ, Guengerich FP. Oxidation of indole by cytochrome P450 enzymes. Biochemistry. 39: 13817-24. PMID 11076521 DOI: 10.1021/bi001229u  0.321
2000 Shimada T, Tsumura F, Gillam EMJ, Guengerich FP, Inoue K. Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Protein Expression and Purification. 20: 73-80. PMID 11035953 DOI: 10.1006/Prep.2000.1302  0.389
2000 Aryal P, Terashita T, Guengerich FP, Shimada T, Oda Y. Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. Environmental and Molecular Mutagenesis. 36: 121-6. PMID 11013410 DOI: 10.1002/1098-2280(2000)36:2<121::Aid-Em6>3.0.Co;2-P  0.348
2000 Yun CH, Miller GP, Guengerich FP. Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants Biochemistry. 39: 11319-11329. PMID 10985777 DOI: 10.1021/Bi000869U  0.424
2000 Hosea NA, Miller GP, Guengerich FP. Elucidation of distinct ligand binding sites for cytochrome P450 3A4 Biochemistry. 39: 5929-5939. PMID 10821664 DOI: 10.1021/Bi992765T  0.38
2000 Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chemical Research in Toxicology. 13: 245-52. PMID 10775323 DOI: 10.1021/TX990189W  0.725
2000 Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ. Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. The Journal of Biological Chemistry. 275: 11784-90. PMID 10766802 DOI: 10.1074/Jbc.275.16.11784  0.449
2000 Einolf HJ, Guengerich FP. Kinetic analysis of nucleotide incorporation by mammalian DNA polymerase delta. The Journal of Biological Chemistry. 275: 16316-22. PMID 10748013 DOI: 10.1074/Jbc.M001291200  0.353
2000 Hanna IH, Reed JR, Guengerich FP, Hollenberg PF. Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver. Archives of Biochemistry and Biophysics. 376: 206-16. PMID 10729207 DOI: 10.1006/Abbi.2000.1708  0.622
2000 Guengerich FP. Metabolism of chemical carcinogens Carcinogenesis. 21: 345-351. PMID 10688854 DOI: 10.1093/Carcin/21.3.345  0.347
2000 Shimada T, Tsumura F, Yamazaki H, Guengerich FP, Inoue K. Relationships Between Genetic Polymorphisms In Cyp2D6 And Cyp2E1 Genes And Liver Microsomal Drug Oxidation Activities Drug Metabolism and Pharmacokinetics. 15: 84-85. DOI: 10.2133/Dmpk.15.Supplement_84  0.357
2000 Upadhyaya P, Carmella SG, Guengerich F, Hecht SS. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues Carcinogenesis. 21: 1233-1238. DOI: 10.1093/Carcin/21.6.1233  0.329
2000 Sato H, Guengerich FP. Oxidation of 1,2,4,5-tetramethoxybenzene to a cation radical by cytochrome P450 [15] Journal of the American Chemical Society. 122: 8099-8100. DOI: 10.1021/Ja000838M  0.348
2000 Guengerich FP. Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics Drug Development Research. 49: 4-16. DOI: 10.1002/(Sici)1098-2299(200001)49:1<4::Aid-Ddr2>3.0.Co;2-R  0.302
1999 Lewis DFV, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP. Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Toxicology. 139: 53-79. PMID 10614688 DOI: 10.1016/S0300-483X(99)00098-0  0.377
1999 Gillam EM, Aguinaldo AM, Notley LM, Kim D, Mundkowski RG, Volkov AA, Arnold FH, Soucek P, DeVoss JJ, Guengerich FP. Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications. 265: 469-72. PMID 10558891 DOI: 10.1006/Bbrc.1999.1702  0.586
1999 Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 27: 1260-6. PMID 10534310  0.315
1999 Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP. Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. Mutation Research. 429: 199-208. PMID 10526205 DOI: 10.1016/S0027-5107(99)00120-7  0.358
1999 Guengerich FP, Parikh A, Turesky RJ, Josephy PD. Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. Mutation Research. 428: 115-24. PMID 10517985 DOI: 10.1016/S1383-5742(99)00039-3  0.439
1999 Turesky RJ, Constable A, Fay LB, Guengerich FP. Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2. Cancer Letters. 143: 109-12. PMID 10503887 DOI: 10.1016/S0304-3835(99)00137-8  0.448
1999 Chun YJ, Kim MY, Guengerich FP. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochemical and Biophysical Research Communications. 262: 20-4. PMID 10448061 DOI: 10.1006/Bbrc.1999.1152  0.405
1999 Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 20: 1607-13. PMID 10426814 DOI: 10.1093/Carcin/20.8.1607  0.4
1999 Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chemical Research in Toxicology. 12: 623-9. PMID 10409402 DOI: 10.1021/Tx990028S  0.356
1999 Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y. Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. Mutation Research. 442: 113-20. PMID 10393280 DOI: 10.1016/S1383-5718(99)00070-4  0.408
1999 Yun C, Ahn T, Guengerich FP, Yamazaki H, Shimada T. Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. Archives of Biochemistry and Biophysics. 367: 81-88. PMID 10375402 DOI: 10.1006/Abbi.1999.1254  0.407
1999 Parikh A, Josephy PD, Guengerich FP. Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry. 38: 5283-9. PMID 10220313 DOI: 10.1021/bi990142+  0.308
1999 Nedelcheva V, Gut I, Souček P, Tichavská B, Týnkova L, Mráz J, Guengerich FP, Ingelman-Sundberg M. Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. Archives of Toxicology. 73: 33-40. PMID 10207612 DOI: 10.1007/S002040050583  0.366
1999 Furge LL, Guengerich FP. Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. Biochemistry. 38: 4818-25. PMID 10200170 DOI: 10.1021/BI982163U  0.701
1999 Cai Y, Marcus C, Guengerich FP, Gelboin HV, Baird WM. Roles of cytochrome P450 1a1 and 1b1 in metabolic activation of dibenzo[a,l]pyrene by microsomes from the human mammary carcinoma cell line MCF-7 Polycyclic Aromatic Compounds. 16: 109-118. DOI: 10.1080/10406639908020578  0.396
1998 Guengerich FP, Hosea NA, Martin MV. Purification of cytochromes P450: products of bacterial recombinant expression systems. Methods in Molecular Biology (Clifton, N.J.). 107: 77-83. PMID 14577214 DOI: 10.1385/0-89603-519-0:77  0.4
1998 Guengerich FP, Martin MV. Purification of cytochromes P450. Rat and human hepatic forms Methods in Molecular Biology (Clifton, N.J.). 107: 35-53. PMID 14577211 DOI: 10.1385/0-89603-519-0:35  0.351
1998 Nunes MG, Desai D, Koehl W, Spratt TE, Guengerich FP, Amin S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study. Cancer Letters. 129: 131-8. PMID 9719453 DOI: 10.1016/S0304-3835(98)00049-4  0.373
1998 Turesky RJ, Constable A, Richoz J, Varga N, Markovic J, Martin MV, Guengerich FP. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chemical Research in Toxicology. 11: 925-36. PMID 9705755 DOI: 10.1021/tx980022n  0.307
1998 Yun C, Ahn T, Guengerich FP. Conformational Change and Activation of Cytochrome P450 2B1 Induced by Salt and Phospholipid Archives of Biochemistry and Biophysics. 356: 229-238. PMID 9705213 DOI: 10.1006/Abbi.1998.0759  0.372
1998 Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Biochemical Pharmacology. 56: 243-51. PMID 9698079 DOI: 10.1016/S0006-2952(98)00133-6  0.383
1998 Guengerich FP, Shimada T. Activation of procarcinogens by human cytochrome P450 enzymes Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 400: 201-213. PMID 9685642 DOI: 10.1016/S0027-5107(98)00037-2  0.424
1998 Guengerich FP, Johnson WW, Shimada T, Ueng Y, Yamazaki H, Langouët S. Activation and detoxication of aflatoxin B1 Mutation Research. 402: 121-128. PMID 9675258 DOI: 10.1016/S0027-5107(97)00289-3  0.486
1998 Shen J, Moy JA, Green MD, Guengerich FP, Baron J. Immunohistochemical demonstration of beta-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells. Hepatology (Baltimore, Md.). 27: 1483-91. PMID 9620317 DOI: 10.1002/Hep.510270604  0.327
1998 Hosea NA, Guengerich FP. Oxidation of nonionic detergents by cytochrome P450 enzymes. Archives of Biochemistry and Biophysics. 353: 365-73. PMID 9606971 DOI: 10.1006/abbi.1998.0659  0.32
1998 Furge LL, Guengerich FP. Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. Biochemistry. 37: 3567-74. PMID 9521678 DOI: 10.1021/bi9722094  0.682
1998 Josephy PD, Evans DH, Parikh A, Guengerich FP. Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli. Chemical Research in Toxicology. 11: 70-4. PMID 9477228 DOI: 10.1021/tx970171q  0.327
1998 Hosea NA, Guengerich FP. Oxidation of nonionic detergents by cytochrome P450 enzymes Faseb Journal. 12. DOI: 10.1006/Abbi.1998.0659  0.436
1998 Guengerich FP, Hosea NA. Cytochrome P450 3A4: Diversity of reactions, cooperativity, and component interactions Proceedings of the Western Pharmacology Society. 41: 267.  0.318
1997 Guengerich FP. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species Chemico-Biological Interactions. 106: 161-182. PMID 9413544 DOI: 10.1016/S0009-2797(97)00068-9  0.439
1997 Shaw PM, Hosea NA, Thompson DV, Lenius JM, Guengerich FP. Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5. Archives of Biochemistry and Biophysics. 348: 107-15. PMID 9390180 DOI: 10.1006/Abbi.1997.0378  0.455
1997 Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H. Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Cancer Research. 57: 4757-64. PMID 9354437  0.322
1997 Guengerich FP, Parikh A. Expression of drug-metabolizing enzymes Current Opinion in Biotechnology. 8: 623-628. PMID 9353222 DOI: 10.1016/S0958-1669(97)80039-0  0.337
1997 Parikh A, Gillam EM, Guengerich FP. Drug metabolism by Escherichia coli expressing human cytochromes P450. Nature Biotechnology. 15: 784-8. PMID 9255795 DOI: 10.1038/nbt0897-784  0.312
1997 Yamazaki H, Gillam EMJ, Dong M, Johnson WW, Guengerich FP, Shimada T. Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Archives of Biochemistry and Biophysics. 342: 329-337. PMID 9186495 DOI: 10.1006/Abbi.1997.0125  0.409
1997 Furge LL, Guengerich FP. Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Biochemistry. 36: 6475-87. PMID 9174365 DOI: 10.1021/bi9627267  0.683
1997 Kelly JD, Eaton DL, Guengerich FP, Coulombe RA. Aflatoxin B1 Activation in Human Lung Toxicology and Applied Pharmacology. 144: 88-95. PMID 9169073 DOI: 10.1006/Taap.1997.8117  0.339
1997 Anderson KE, Hammons GJ, Kadlubar FF, Potter JD, Kaderlik KR, Ilett KF, Minchin RF, Teitel CH, Chou HC, Martin MV, Guengerich FP, Barone GW, Lang NP, Peterson LA. Metabolic activation of aromatic amines by human pancreas. Carcinogenesis. 18: 1085-92. PMID 9163700 DOI: 10.1093/Carcin/18.5.1085  0.362
1997 Shimada T, Gillam EMJ, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1 Drug Metabolism and Disposition. 25: 617-622. PMID 9152602  0.354
1997 Parikh A, Guengerich FP. Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:Rat NADPH-cytochrome P450 reductase fusion protein Protein Expression and Purification. 9: 346-354. PMID 9126606 DOI: 10.1006/Prep.1997.0721  0.44
1997 Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 18: 851-4. PMID 9111224 DOI: 10.1093/Carcin/18.4.851  0.327
1997 Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP. Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes. Chemical Research in Toxicology. 10: 91-102. PMID 9074808 DOI: 10.1021/tx960064g  0.331
1997 Guengerich FP, Vaz AD, Raner GN, Pernecky SJ, Coon MJ. Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. Molecular Pharmacology. 51: 147-51. PMID 9016357 DOI: 10.1124/Mol.51.1.147  0.595
1997 Ueng YF, Kuwabara T, Chun YJ, Guengerich FP. Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry. 36: 370-81. PMID 9003190 DOI: 10.1021/Bi962359Z  0.406
1997 Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochemical Pharmacology. 53: 111-6. PMID 8960070 DOI: 10.1016/S0006-2952(96)00693-4  0.371
1997 Guengerich FP, Humphreys WG, Yun CH, Hammons GJ, Kadlubar FF, Seto Y, Okazaki O, Martin MV. Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues. Princess Takamatsu Symposia. 23: 78-84. PMID 8844798  0.351
1997 Shimada T, Inoue K, Shaw PM, Guengerich FP, Yamazaki H. Omeprazole Hydroxylation By Cyp2C19 And Cyp3A4: Prediction Towards Human Liver Activities Using The Data Of Recombinant P450 Enzymes Drug Metabolism and Pharmacokinetics. 12: 120-121. DOI: 10.2133/Dmpk.12.Supplement_120  0.389
1997 Guengerich FP, Johnson WW, Kim M, Müller M, Langouët S. O I.1 Chemistry of DNA-carcinogen adducts: Formation and biological effects Mutation Research. 379. DOI: 10.1016/S0027-5107(97)82613-9  0.339
1996 Mancy A, Dijol S, Poli S, Guengerich FP, Mansuy D. Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9 Biochemistry. 35: 16205-16212. PMID 8973193 DOI: 10.1021/Bi961950T  0.352
1996 Yamazaki H, Johnson WW, Ueng Y, Shimada T, Guengerich FP. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. Journal of Biological Chemistry. 271: 27438-27444. PMID 8910324 DOI: 10.1074/Jbc.271.44.27438  0.405
1996 Guengerich FP, Yun CH, Macdonald TL. Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates. The Journal of Biological Chemistry. 271: 27321-9. PMID 8910308 DOI: 10.1074/Jbc.271.44.27321  0.34
1996 Müller M, Belas F, Ueno H, Guengerich FP. Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-a]Purine in DNA Modified by 2-Chloro-Oxirane Advances in Experimental Medicine and Biology. 387: 31-36. PMID 8794191 DOI: 10.1007/978-1-4757-9480-9_5  0.383
1996 Guengerich FP, Martin MV, Guo Z, Chun Y. Purification Of Functional Recombinant P450S From Bacteria Methods in Enzymology. 272: 35-44. PMID 8791760 DOI: 10.1016/S0076-6879(96)72006-2  0.371
1996 Guengerich FP, Johnson WW, Ueng YF, Yamazaki H, Shimada T. Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Environmental Health Perspectives. 104: 557-562. PMID 8781383 DOI: 10.1289/Ehp.96104S3557  0.327
1996 Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesthesia and Analgesia. 82: 167-72. PMID 8712396 DOI: 10.1097/00000539-199601000-00031  0.301
1996 Yamazaki H, Nakano M, Gillam EM, Bell LC, Guengerich FP, Shimada T. Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical Pharmacology. 52: 301-9. PMID 8694855 DOI: 10.1016/0006-2952(96)00208-0  0.306
1996 Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, Sutter TR. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1 Cancer Research. 56: 2979-2984. PMID 8674051  0.308
1996 Nakhgevany R, Bonsu O, Barber J, Mabrouk PA, Ueng YF, Bell LC, Guengerich FP. Preparation, purification, and spectrophotometric characterization of cytochrome P450 1A2 conjugated with polyethylene glycol monomethyl ether. Biochemical and Biophysical Research Communications. 222: 406-9. PMID 8670218 DOI: 10.1006/Bbrc.1996.0757  0.41
1996 Chun Y, Shimada T, Guengerich FP. Construction of a Human Cytochrome P450 1A1:Rat NADPH–Cytochrome P450 Reductase Fusion Protein cDNA and Expression inEscherichia coli,Purification, and Catalytic Properties of the Enzyme in Bacterial Cells and after Purification Archives of Biochemistry and Biophysics. 330: 48-58. PMID 8651703 DOI: 10.1006/Abbi.1996.0224  0.414
1996 Smith TJ, Guo Z, Guengerich FP, Yang CS. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. Carcinogenesis. 17: 809-13. PMID 8625495 DOI: 10.1093/Carcin/17.4.809  0.402
1996 Ingelman-Sundberg M, Hagbjörk AL, Ueng YF, Yamazaki H, Guengerich FP. High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge. Biochemical and Biophysical Research Communications. 221: 318-22. PMID 8619853 DOI: 10.1006/Bbrc.1996.0593  0.322
1996 Tateishi T, Wood AJ, Guengerich FP, Wood M. Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. Biochemical Pharmacology. 50: 1921-4. PMID 8615873 DOI: 10.1016/0006-2952(95)02088-8  0.332
1996 Dong M, Yamazaki H, Guo Z, Guengerich FP. Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics. 327: 11-19. PMID 8615680 DOI: 10.1006/Abbi.1996.0086  0.339
1996 Yamazaki H, Inoue K, Mimura M, Oda Y, Guengerich FP, Shimada T. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. Biochemical Pharmacology. 51: 313-9. PMID 8573198 DOI: 10.1016/0006-2952(95)02178-7  0.33
1996 Yamazaki H, Nakano M, Imai Y, Ueng Y, Guengerich FP, Shimada T. Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes Archives of Biochemistry and Biophysics. 325: 174-182. PMID 8561495 DOI: 10.1006/Abbi.1996.0022  0.316
1996 Werner M, Guo Z, Birner G, Dekant W, Guengerich FP. The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes. Chemical Research in Toxicology. 8: 917-23. PMID 8555406 DOI: 10.1021/tx00049a004  0.319
1996 Koehl W, Amin S, Staretz ME, Ueng YF, Yamazaki H, Tateishi T, Guengerich FP, Hecht SS. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes. Cancer Research. 56: 316-24. PMID 8542586  0.302
1996 Miller MS, Juchau MR, Guengerich FP, Nebert DW, Raucy JL. Drug Metabolic Enzymes in Developmental Toxicology Toxicological Sciences. 34: 165-175. DOI: 10.1093/Toxsci/34.2.165  0.325
1996 Koehl W, Amin S, Yamazaki H, Ueng Y, Tateishi T, Guengerich FP, Hecht SS. Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes Polycyclic Aromatic Compounds. 10: 59-66. DOI: 10.1080/10406639608034680  0.382
1996 Johnson WW, Harris aTM, Guengerich FP. Kinetics And Mechanism Of Hydrolysis Of Aflatoxin B1 Exo-8,9-Epoxide And Rearrangement Of The Dihydrodiol Journal of the American Chemical Society. 118: 8213-8220. DOI: 10.1021/Ja960525K  0.378
1995 Pichard L, Curi-Pedrosa R, Bonfils C, Jacqz-Aigrain E, Domergue J, Joyeux H, Cosme J, Guengerich FP, Maurel P. Oxidative metabolism of lansoprazole by human liver cytochromes P450. Molecular Pharmacology. 47: 410-8. PMID 7870052  0.321
1995 Yun CH, Jeong HG, Jhoun JW, Guengerich FP. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis. 16: 1437-40. PMID 7788866 DOI: 10.1093/carcin/16.6.1437  0.316
1995 Ueng Y, Shimada T, Yamazaki H, Guengerich FP. Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology. 8: 218-225. PMID 7766804 DOI: 10.1021/Tx00044A006  0.321
1995 Bauer E, Guo Z, Ueng YF, Bell LC, Zeldin D, Guengerich FP. Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology. 8: 136-42. PMID 7703357  0.326
1995 Yamazaki H, Ueng Y, Shimada T, Guengerich FP. Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen Surrogates Biochemistry. 34: 8380-8389. PMID 7599128 DOI: 10.1021/Bi00026A020  0.305
1995 Guengerich FP, Thier R, Persmark M, Taylor JB, Pemble SE, Ketterer B. Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics. 5: S103-7. PMID 7581478 DOI: 10.1097/00008571-199512001-00010  0.33
1995 Thier R, Müller M, Taylor JB, Pemble SE, Ketterer B, Guengerich FP. Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. Chemical Research in Toxicology. 8: 465-72. PMID 7578934 DOI: 10.1021/Tx00045A019  0.336
1995 Shimada T, Yamazaki H, Guengerich FP. Metabolic Activation of Procarcinogens by Human Cytochrome P450 Enzymes in Microsomes of Adult and Fetal Livers and of Adult Lungs Drug Metabolism and Pharmacokinetics. 10: 126-129. DOI: 10.2133/Dmpk.10.Supplement_126  0.401
1994 Yamazaki H, Mimura M, Oda Y, Gonzalez FJ, el-Bayoumy K, Chae YH, Guengerich FP, Shimada T. Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. Carcinogenesis. 15: 465-70. PMID 8118930 DOI: 10.1093/Carcin/15.3.465  0.372
1994 Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. Archives of Biochemistry and Biophysics. 309: 168-77. PMID 8117105 DOI: 10.1006/Abbi.1994.1099  0.317
1994 Degawa M, Stern SJ, Martin MV, Guengerich FP, Fu PP, Ilett KF, Kaderlik RK, Kadlubar FF. Metabolic activation and carcinogen-DNA adduct detection in human larynx. Cancer Research. 54: 4915-9. PMID 8069857  0.341
1994 Guo Z, Gillam EM, Ohmori S, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. Archives of Biochemistry and Biophysics. 312: 436-46. PMID 8037457 DOI: 10.1006/Abbi.1994.1330  0.318
1994 Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. The Journal of Pharmacology and Experimental Therapeutics. 270: 414-23. PMID 8035341  0.307
1994 Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP. Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis. 15: 2523-9. PMID 7955101 DOI: 10.1093/Carcin/15.11.2523  0.306
1994 Kazakoff K, Iversen P, Lawson T, Baron J, Guengerich FP, Pour PM. Involvement of cytochrome P450 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa European Journal of Cancer. Part B: Oral Oncology. 30: 179-185. PMID 7920164 DOI: 10.1016/0964-1955(94)90088-4  0.391
1994 Mimura M, Baba T, Yamazaki H, Ohmori S, Inui Y, Gonzalez FJ, Guengerich FP, Shimada T. Characterization of cytochrome P-450 2B6 in human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 21: 1048-56. PMID 7905383  0.324
1994 Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 Journal of Human Genetics. 39: 337-343. PMID 7841444 DOI: 10.1007/Bf01874052  0.311
1994 Seto Y, Okazaki O, Guengerich FP. Mechanism Of N -Oxidation Reaction Catalyzed By Cytochrome P-450 Drug Metabolism and Pharmacokinetics. 9: 172-175. DOI: 10.2133/Dmpk.9.Supplement_172  0.369
1994 Iyer RS, Coles BF, Raney KD, Thier R, Guengerich FP, Harris TM. DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies Journal of the American Chemical Society. 116: 1603-1609. DOI: 10.1021/Ja00084A001  0.408
1993 Lopez Garcia MP, Dansette PM, Valadon P, Amar C, Beaune PH, Guengerich FP, Mansuy D. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. European Journal of Biochemistry. 213: 223-32. PMID 8477697 DOI: 10.1111/J.1432-1033.1993.Tb17752.X  0.41
1993 Stern SJ, Degawa M, Martin MV, Guengerich FP, Kaderlik RK, Ilett KF, Breau R, McGhee M, Montague D, Lyn-Cook B. Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue. Journal of Cellular Biochemistry. Supplement. 17: 129-37. PMID 8412184 DOI: 10.1002/Jcb.240531018  0.392
1993 Ohmori S, Horie T, Guengerich FP, Kiuchi M, Kitada M. Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys. Archives of Biochemistry and Biophysics. 305: 405-13. PMID 8373178 DOI: 10.1006/abbi.1993.1439  0.31
1993 Gillam EM, Baba T, Kim BR, Ohmori S, Guengerich FP. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. Archives of Biochemistry and Biophysics. 305: 123-31. PMID 8342945 DOI: 10.1006/abbi.1993.1401  0.336
1993 Yamazaki H, Mimura M, Oda Y, Inui Y, Shiraga T, Iwasaki K, Guengerich FP, Shimada T. Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. Carcinogenesis. 14: 1271-8. PMID 8330339 DOI: 10.1093/Carcin/14.7.1271  0.386
1993 Meyer DJ, Coles B, Harris J, Gilmore KS, Raney K, Harris TM, Guengerich FP, Kensler TW, Ketterer B. Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties. Basic Life Sciences. 61: 171-9. PMID 8304929 DOI: 10.1007/978-1-4615-2984-2_16  0.325
1993 Guengerich FP, Gillam EM, Ohmori S, Sandhu P, Brian WR, Sari MA, Iwasaki M. Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity. Toxicology. 82: 21-37. PMID 8236276 DOI: 10.1016/0300-483x(93)90057-y  0.307
1993 Yun CH, Okerholm RA, Guengerich FP. Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 21: 403-9. PMID 8100494  0.33
1993 Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Dna and Cell Biology. 12: 1-51. PMID 7678494 DOI: 10.1089/Dna.1993.12.1  0.559
1993 Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Ballet F, Feldmann G, Guengerich FP, Pessayre D. Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology. 104: 203-16. PMID 7678237 DOI: 10.1016/0016-5085(93)90853-5  0.334
1992 Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FP. Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. Chemical Research in Toxicology. 2: 114-2. PMID 2519710 DOI: 10.1021/Tx00008A008  0.391
1992 Knodell RG, Browne DG, Gwozdz GP, Brian WR, Guengerich FP. Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology. 101: 1680-91. PMID 1955133 DOI: 10.1016/0016-5085(91)90408-D  0.427
1992 Yun CH, Shimada T, Guengerich FP. Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). Carcinogenesis. 13: 217-22. PMID 1740010 DOI: 10.1093/carcin/13.2.217  0.336
1992 Raney KD, Shimada T, Kim DH, Groopman JD, Harris TM, Guengerich FP. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chemical Research in Toxicology. 5: 202-10. PMID 1643250 DOI: 10.1021/Tx00026A009  0.564
1992 Csanády GA, Guengerich FP, Bond JA. Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis. 13: 1143-53. PMID 1638680 DOI: 10.1093/Carcin/13.7.1143  0.358
1992 Guengerich FP, Raney KD, Kim DH, Shimada T, Meyer DJ, Ketterer B, Harris TM. Oxidation and conjugation of aflatoxins by humans and experimental animals. Progress in Clinical and Biological Research. 374: 157-65. PMID 1620701  0.403
1992 Yamazaki H, Oda Y, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada T. Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). Carcinogenesis. 13: 979-85. PMID 1600620 DOI: 10.1093/Carcin/13.6.979  0.421
1992 Fleming CM, Branch RA, Wilkinson GR, Guengerich FP. Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4. Molecular Pharmacology. 41: 975-80. PMID 1588928  0.349
1992 Guengerich FP. Human cytochrome P-450 enzymes. Life Sciences. 50: 1471-1478. PMID 1579042 DOI: 10.1016/0024-3205(92)90136-D  0.419
1992 Guengerich FP. Metabolic activation of carcinogens. Pharmacology & Therapeutics. 54: 17-61. PMID 1528954 DOI: 10.1016/0163-7258(92)90050-A  0.352
1992 Yun CH, Wood M, Wood AJ, Guengerich FP. Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Anesthesiology. 77: 467-74. PMID 1519785 DOI: 10.1097/00000542-199209000-00011  0.35
1992 Yamazaki H, Inui Y, Yun C, Guengerich FP, Shimada T. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes Carcinogenesis. 13: 1789-1794. PMID 1423839 DOI: 10.1093/Carcin/13.10.1789  0.446
1992 Shimada T, Yamazaki H, Mimura M, Guengerich FP. Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. Mutation Research. 284: 233-241. PMID 1281274 DOI: 10.1016/0027-5107(92)90007-O  0.401
1992 Guengerich FP, Raney VM. Formation of etheno adducts of adenosine and cytidine from 1-halooxiranes. Evidence for a mechanism involving initial reaction with the endocyclic nitrogen atoms Journal of the American Chemical Society. 114: 1074-1080. DOI: 10.1021/Ja00029A041  0.32
1992 Kadlubar FF, Guengerich FP. Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens Chemosphere. 25: 201-204. DOI: 10.1016/0045-6535(92)90513-Q  0.379
1991 Brian WR, Sari MA, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FP. Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry. 29: 11280-92. PMID 2271712 DOI: 10.1021/bi00503a018  0.332
1991 Guengerich FP, Shimada T, Bondon A, Macdonald TL. Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. Advances in Experimental Medicine and Biology. 283: 1-11. PMID 2068975 DOI: 10.1007/978-1-4684-5877-0_1  0.399
1991 Guengerich FP, Brian WR, Iwasaki M, Sari MA, Baeaernhielm C, Berntsson P. Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. Journal of Medicinal Chemistry. 34: 1838-1844. PMID 2061924 DOI: 10.1021/Jm00110A012  0.435
1991 Miranda CL, Reed RL, Guengerich FP, Buhler DR. Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver Carcinogenesis. 12: 515-519. PMID 2009596 DOI: 10.1093/Carcin/12.3.515  0.374
1991 Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. Dna and Cell Biology. 10: 1-14. PMID 1991046 DOI: 10.1089/Dna.1991.10.1  0.542
1991 Yamazaki H, Degawa M, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada T. Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes. Carcinogenesis. 12: 133-9. PMID 1988174 DOI: 10.1093/Carcin/12.1.133  0.393
1991 Guengerich FP. Molecular advances for the cytochrome P-450 superfamily Trends in Pharmacological Sciences. 12: 281-283. PMID 1949194 DOI: 10.1016/0165-6147(91)90574-C  0.346
1991 Yun CH, Shimada T, Guengerich FP. Purification and characterization of human liver microsomal cytochrome P-450 2A6. Molecular Pharmacology. 40: 679-85. PMID 1944238  0.331
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