| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2013 | Peterson EJ, Kireev D, Moon AF, Midon M, Janzen WP, Pingoud A, Pedersen LC, Singleton SF. Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay. Journal of Biomolecular Screening. 18: 247-57. PMID 23015019 DOI: 10.1177/1087057112461153 | 0.445 | |||
| 2012 | Carroll MJ, Mauldin RV, Gromova AV, Singleton SF, Collins EJ, Lee AL. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nature Chemical Biology. 8: 246-52. PMID 22246400 DOI: 10.1038/Nchembio.769 | 0.301 | |||
| 2012 | Peterson EJ, Janzen WP, Kireev D, Singleton SF. High-throughput screening for RecA inhibitors using a transcreener adenosine 5'-O-diphosphate assay. Assay and Drug Development Technologies. 10: 260-8. PMID 22192312 DOI: 10.1089/Adt.2011.0409 | 0.427 | |||
| 2011 | Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL. Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. Journal of the American Chemical Society. 133: 6422-8. PMID 21469679 DOI: 10.1021/Ja2005253 | 0.306 | |||
| 2010 | Sexton JZ, Wigle TJ, He Q, Hughes MA, Smith GR, Singleton SF, Williams AL, Yeh LA. Novel Inhibitors of E. coli RecA ATPase Activity. Current Chemical Genomics. 4: 34-42. PMID 20648224 DOI: 10.2174/1875397301004010034 | 0.334 | |||
| 2009 | Wigle TJ, Sexton JZ, Gromova AV, Hadimani MB, Hughes MA, Smith GR, Yeh LA, Singleton SF. Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coli. Journal of Biomolecular Screening. 14: 1092-101. PMID 19675313 DOI: 10.1177/1087057109342126 | 0.326 | |||
| 2007 | Singleton SF, Roca AI, Lee AM, Xiao J. Probing the structure of RecA-DNA filaments. Advantages of a fluorescent guanine analog. Tetrahedron. 63: 3553-3566. PMID 17955055 DOI: 10.1016/J.Tet.2006.10.092 | 0.596 | |||
| 2007 | Lee AM, Wigle TJ, Singleton SF. A complementary pair of rapid molecular screening assays for RecA activities. Analytical Biochemistry. 367: 247-58. PMID 17601483 DOI: 10.1016/J.Ab.2007.04.021 | 0.455 | |||
| 2007 | Cline DJ, Holt SL, Singleton SF. Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix. Organic & Biomolecular Chemistry. 5: 1525-8. PMID 17571180 DOI: 10.1039/B703159A | 0.385 | |||
| 2006 | Xiao J, Lee AM, Singleton SF. Direct evaluation of a kinetic model for RecA-mediated DNA-strand exchange: the importance of nucleic acid dynamics and entropy during homologous genetic recombination. Chembiochem : a European Journal of Chemical Biology. 7: 1265-78. PMID 16847846 DOI: 10.1002/Cbic.200600038 | 0.634 | |||
| 2006 | Lee AM, Xiao J, Singleton SF. Origins of sequence selectivity in homologous genetic recombination: insights from rapid kinetic probing of RecA-mediated DNA strand exchange. Journal of Molecular Biology. 360: 343-59. PMID 16756994 DOI: 10.1016/J.Jmb.2006.04.065 | 0.591 | |||
| 2006 | Lee AM, Singleton SF. Intersubunit electrostatic complementarity in the RecA nucleoprotein filament regulates nucleotide substrate specificity and conformational activation. Biochemistry. 45: 4514-29. PMID 16584187 DOI: 10.1021/Bi052296X | 0.481 | |||
| 2006 | Wigle TJ, Lee AM, Singleton SF. Conformationally selective binding of nucleotide analogues to Escherichia coli RecA: a ligand-based analysis of the RecA ATP binding site. Biochemistry. 45: 4502-13. PMID 16584186 DOI: 10.1021/Bi052298H | 0.441 | |||
| 2006 | Xiao J, Lee AM, Singleton SF. Construction and evaluation of a kinetic scheme for RecA-mediated DNA strand exchange. Biopolymers. 81: 473-96. PMID 16421856 DOI: 10.1002/Bip.20446 | 0.624 | |||
| 2006 | Xiao J, Lee AM, Singleton SF. Cover Picture: Direct Evaluation of a Kinetic Model for RecA-Mediated DNA-strand exchange: The Importance of Nucleic Acid Dynamics and Entropy During Homologous Genetic Recombination (ChemBioChem 8/2006) Chembiochem. 7: 1129-1129. DOI: 10.1002/Cbic.200690024 | 0.542 | |||
| 2005 | Lee AM, Ross CT, Zeng BB, Singleton SF. A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP. Journal of Medicinal Chemistry. 48: 5408-11. PMID 16107138 DOI: 10.1021/Jm050113Z | 0.359 | |||
| 2004 | Lee AM, Singleton SF. Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates. Journal of Inorganic Biochemistry. 98: 1981-6. PMID 15522426 DOI: 10.1016/J.Jinorgbio.2004.08.018 | 0.421 | |||
| 2003 | Roca AI, Singleton SF. Direct evaluation of a mechanism for activation of the RecA nucleoprotein filament. Journal of the American Chemical Society. 125: 15366-75. PMID 14664581 DOI: 10.1021/Ja0270165 | 0.551 | |||
| 2002 | Singleton SF, Simonette RA, Sharma NC, Roca AI. Intein-mediated affinity-fusion purification of the Escherichia coli RecA protein. Protein Expression and Purification. 26: 476-88. PMID 12460773 DOI: 10.1016/S1046-5928(02)00571-5 | 0.571 | |||
| 2002 | Xiao J, Singleton SF. Elucidating a key intermediate in homologous DNA strand exchange: structural characterization of the RecA-triple-stranded DNA complex using fluorescence resonance energy transfer. Journal of Molecular Biology. 320: 529-58. PMID 12096908 DOI: 10.1016/S0022-2836(02)00462-X | 0.615 | |||
| 2001 | Singleton SF, Xiao J. The stretched DNA geometry of recombination and repair nucleoprotein filaments. Biopolymers. 61: 145-58. PMID 11987178 DOI: 10.1002/Bip.10145 | 0.613 | |||
| 2001 | Singleton SF, Shan F, Kanan MW, McIntosh CM, Stearman CJ, Helm JS, Webb KJ. Facile synthesis of a fluorescent deoxycytidine analogue suitable for probing the RecA nucleoprotein filament. Organic Letters. 3: 3919-22. PMID 11720569 DOI: 10.1021/Ol0167863 | 0.407 | |||
| 2001 | Berger MD, Lee AM, Simonette RA, Jackson BE, Roca AI, Singleton SF. Design and evaluation of a tryptophanless RecA protein with wild type activity Biochemical and Biophysical Research Communications. 286: 1195-1203. PMID 11527427 DOI: 10.1006/Bbrc.2001.5525 | 0.478 | |||
| 1992 | Singleton SF, Dervan PB. Thermodynamics of oligodeoxyribonucleotide-directed triple helix formation: an analysis using quantitative affinity cleavage titration Journal of the American Chemical Society. 114: 6957-6965. DOI: 10.1021/Ja00044A002 | 0.414 | |||
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