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Tad Harbison Koch, Ph.D. - Publications

Affiliations: 
1968- Chemistry University of Colorado, Boulder, Boulder, CO, United States 
Area:
Biochemistry, Pharmaceutical Chemistry, nucleic acids
Website:
http://www.colorado.edu/chembio/tad-koch
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ganesh AN, Aman A, Logie J, Barthel BL, Cogan P, Al-Awar R, Koch TH, Shoichet BK, Shoichet MS. Colloidal drug aggregate stability in high serum conditions and pharmacokinetic consequence. Acs Chemical Biology. PMID 30840432 DOI: 10.1021/Acschembio.9B00032  0.659
2019 Tamura R, Balabanova A, Frakes SA, Bargmann A, Grimm J, Koch TH, Yin HH. Photoactivatable Prodrug of Doxazolidine Targeting Exosomes. Journal of Medicinal Chemistry. PMID 30703330 DOI: 10.1021/Acs.Jmedchem.8B01508  0.437
2017 Ganesh AN, Logie J, McLaughlin CK, Barthel BL, Koch TH, Shoichet BK, Shoichet MS. Leveraging colloidal aggregation for drug-rich nanoparticle formulations. Molecular Pharmaceutics. PMID 28502177 DOI: 10.1021/Acs.Molpharmaceut.6B01015  0.659
2016 Barthel BL, Mooz EL, Wiener LE, Koch GG, Koch TH. Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde. Journal of Medicinal Chemistry. 59: 2205-21. PMID 26881291 DOI: 10.1021/Acs.Jmedchem.5B01956  0.724
2013 Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B. Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs. Biochemical Pharmacology. 85: 439-47. PMID 23228697 DOI: 10.1016/J.Bcp.2012.11.026  0.71
2012 Barthel BL, Rudnicki DL, Kirby TP, Colvin SM, Burkhart DJ, Koch TH. Synthesis and biological characterization of protease-activated prodrugs of doxazolidine. Journal of Medicinal Chemistry. 55: 6595-607. PMID 22742660 DOI: 10.1021/Jm300714P  0.724
2011 Ugarenko M, Rephaeli A, Nudelman A, Koch TH, Phillips DR, Cutts SM. Abstract A29: Bcl-2 overexpression provides short-term resistance to doxorubicin-DNA adducts but does not protect against longer-term treatments in HL-60 cells. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A29  0.407
2009 Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH. Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine. Journal of Medicinal Chemistry. 52: 7678-88. PMID 19634903 DOI: 10.1021/Jm900694Z  0.777
2008 Koch TH, Barthel BL, Kalet BT, Rudnicki DL, Post GC, Burkhart DJ. Anthracycline-formaldehyde conjugates and their targeted prodrugs. Topics in Current Chemistry. 283: 141-70. PMID 23605631 DOI: 10.1007/128_2007_4  0.732
2008 Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH. Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug Journal of Medicinal Chemistry. 51: 298-304. PMID 18173233 DOI: 10.1021/Jm7011479  0.715
2008 Spencer DM, Bilardi RA, Koch TH, Post GC, Nafie JW, Kimura K, Cutts SM, Phillips DR. DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair. Mutation Research. 638: 110-21. PMID 17961607 DOI: 10.1016/J.Mrfmmm.2007.09.005  0.779
2007 Kalet BT, McBryde MB, Espinosa JM, Koch TH. Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism. Journal of Medicinal Chemistry. 50: 4493-500. PMID 17696516 DOI: 10.1021/Jm070569B  0.795
2006 Burkhart DJ, Barthel BL, Post GC, Kalet BT, Nafie JW, Shoemaker RK, Koch TH. Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases. Journal of Medicinal Chemistry. 49: 7002-12. PMID 17125253 DOI: 10.1021/Jm060597E  0.777
2005 Post GC, Barthel BL, Burkhart DJ, Hagadorn JR, Koch TH. Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA. Journal of Medicinal Chemistry. 48: 7648-57. PMID 16302805 DOI: 10.1021/Jm050678V  0.802
2004 Burkhart DJ, Kalet BT, Coleman MP, Post GC, Koch TH. Doxorubicin-formaldehyde conjugates targeting alphavbeta3 integrin. Molecular Cancer Therapeutics. 3: 1593-604. PMID 15634653  0.774
2004 Burke PJ, Kalet BT, Koch TH. Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. Journal of Medicinal Chemistry. 47: 6509-18. PMID 15588086 DOI: 10.1021/Jm049496B  0.788
2004 Cogan PS, Koch TH. Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera. Journal of Medicinal Chemistry. 47: 5690-9. PMID 15509168 DOI: 10.1021/Jm0495226  0.331
2004 Burke PJ, Koch TH. Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells. Journal of Medicinal Chemistry. 47: 1193-206. PMID 14971899 DOI: 10.1021/Jm030352R  0.624
2004 Cogan P, Fowler C, Post G, Koch T. Doxsaliform: A Novel N-Mannich Base Prodrug of a Doxorubicin Formaldehyde Conjugate Letters in Drug Design & Discovery. 1: 247-255. DOI: 10.2174/1570180043399000  0.757
2003 Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. Journal of Medicinal Chemistry. 46: 5258-70. PMID 14613328 DOI: 10.1021/Jm0303305  0.349
2003 Smith D, Collins BD, Heil J, Koch TH. Sensitivity and specificity of photoaptamer probes. Molecular & Cellular Proteomics : McP. 2: 11-18. PMID 12601078 DOI: 10.1074/Mcp.M200059-Mcp200  0.31
2002 Kato S, Post GC, Bierbaum VM, Koch TH. Chemical ionization mass spectrometric determination of acrolein in human breast cancer cells. Analytical Biochemistry. 305: 251-9. PMID 12054454 DOI: 10.1006/Abio.2002.5682  0.786
2001 Burke PJ, Koch TH. Doxorubicin-formaldehyde conjugate, doxoform: induction of apoptosis relative to doxorubicin. Anticancer Research. 21: 2753-60. PMID 11724351  0.589
2001 Kato S, Burke PJ, Koch TH, Bierbaum VM. Formaldehyde in human cancer cells: detection by preconcentration-chemical ionization mass spectrometry. Analytical Chemistry. 73: 2992-7. PMID 11467545 DOI: 10.1021/Ac001498Q  0.592
2000 Gaudiano G, Koch TH, Lo Bello M, Nuccetelli M, Ravagnan G, Serafino A, Sinibaldi-Vallebona P. Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Inhibition of glutathione S-transferase p1-1 by glutathione conjugates from anthracyclines. Biochemical Pharmacology. 60: 1915-23. PMID 11108808 DOI: 10.1016/S0006-2952(00)00521-9  0.422
2000 Kato S, Burke PJ, Fenick DJ, Taatjes DJ, Bierbaum VM, Koch TH. Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. Chemical Research in Toxicology. 13: 509-16. PMID 10858324 DOI: 10.1021/Tx000008M  0.601
1999 Podell ER, Harrington DJ, Taatjes DJ, Koch TH. Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells Acta Crystallographica Section D: Biological Crystallography. 55: 1516-1523. PMID 10489446 DOI: 10.1107/S0907444999008161  0.438
1999 Taatjes DJ, Fenick DJ, Koch TH. Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines Chemical Research in Toxicology. 12: 588-596. PMID 10409398 DOI: 10.1021/Tx990008Q  0.414
1998 Taatjes DJ, Fenick DJ, Koch TH. Epidoxoform: A hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells Journal of Medicinal Chemistry. 41: 1306-1314. PMID 9548820 DOI: 10.1021/Jm970739S  0.422
1997 Taatjes DJ, Gaudiano G, Koch TH. Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron Chemical Research in Toxicology. 10: 953-961. PMID 9305576 DOI: 10.1021/Tx970064W  0.367
1997 Fenick DJ, Taatjes DJ, Koch TH. Doxoform and daunoform: Anthracycline-formaldehyde conjugates toxic to resistant tumor cells Journal of Medicinal Chemistry. 40: 2452-2461. PMID 9258351 DOI: 10.1021/Jm970237E  0.41
1997 Taatjes DJ, Gaudiano G, Resing K, Koch TH. Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin Journal of Medicinal Chemistry. 40: 1276-1286. PMID 9111302 DOI: 10.1021/Jm960835D  0.383
1996 Taatjes DJ, Gaudiano G, Resing K, Koch TH. Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin Journal of Medicinal Chemistry. 39: 4135-4138. PMID 8863788 DOI: 10.1021/Jm960519Z  0.346
1996 Norris CL, Meisenheimer PL, Koch TH. Mechanistic studies of the 5-iodouracil chromophore relevant to its use in nucleoprotein photo-cross-linking Journal of the American Chemical Society. 118: 5796-5803. DOI: 10.1021/Ja9607852  0.304
1994 Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine Biochemistry. 33: 3364-3373. PMID 8136374 DOI: 10.1021/Bi00177A030  0.34
1994 Gaudiano G, Resing K, Koch TH. Reaction of Anthracycline Antitumor Drugs with Reduced Glutathione. Formation of Aglycon Conjugates Journal of the American Chemical Society. 116: 6537-6544. DOI: 10.1021/Ja00094A007  0.325
1993 Gaudiano G, Frank E, Wysor MS, Averbuch SD, Koch TH. Bi[5,5-bis(hydroxymethyl)-3-methyl-2-oxomorpholin-3-yl] (BHM-3 dimer). A low toxicity, water-soluble, one-electron reducing agent The Journal of Organic Chemistry. 58: 7355-7363. DOI: 10.1021/Jo00078A011  0.3
1991 Gaudiano G, Koch TH. Redox chemistry of anthracycline antitumor drugs and use of captodative radicals as tools for its elucidation and control. Chemical Research in Toxicology. 4: 2-16. PMID 1912296 DOI: 10.1021/Tx00019A001  0.354
1989 Dietz TM, Koch TH. Photochemical reduction of 5-bromouracil by cysteine derivatives and coupling of 5-bromouracil to cystine derivatives Photochemistry and Photobiology. 49: 121-129. PMID 2710822 DOI: 10.1111/J.1751-1097.1989.Tb04085.X  0.304
1989 Egholm M, Koch TH. Coupling of the anthracycline antitumor drug menogaril to 2'-deoxyguanosine through reductive activation Journal of the American Chemical Society. 111: 8291-8293. DOI: 10.1021/Ja00203A047  0.32
1989 Boldt M, Gaudiano G, Haddadin MJ, Koch TH. Formation and reaction of the quinone methide from reductive cleavage of the antitumor drug menogaril Journal of the American Chemical Society. 111: 2283-2292. DOI: 10.1021/Ja00188A050  0.313
1987 Boldt M, Gaudiano G, Koch TH. Substituent effects on the redox chemistry of anthracycline antitumor drugs Journal of Organic Chemistry. 52: 2146-2153. DOI: 10.1021/Jo00387A006  0.315
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