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James I. Fells, Ph.D. - Publications

Affiliations: 
2009 The University of Memphis, Memphis, TN, United States 
Area:
Pharmaceutical Chemistry
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19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Fells JI, Ai X, Weinglass A, Feng W, Lei Y, Finley M, Hoveyda HR, Fraser GL, Machacek M. Identification of Free Fatty Acid Receptor 2 Agonists Using Virtual Screening. Bioorganic & Medicinal Chemistry Letters. 127460. PMID 32755680 DOI: 10.1016/J.Bmcl.2020.127460  0.326
2014 Patil R, Fells JI, Szabó E, Lim KG, Norman DD, Balogh A, Patil S, Strobos J, Miller DD, Tigyi GJ. Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor. Journal of Medicinal Chemistry. 57: 7136-40. PMID 25100502 DOI: 10.1021/Jm5007116  0.529
2014 Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. The Journal of Biological Chemistry. 289: 24079-90. PMID 25035428 DOI: 10.1074/Jbc.M114.572503  0.483
2014 Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The Febs Journal. 281: 1017-28. PMID 24314137 DOI: 10.1111/Febs.12674  0.738
2014 Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. Journal of Biological Chemistry. 289: 33876-33876. DOI: 10.1074/Jbc.A114.572503  0.41
2013 Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology. 84: 415-24. PMID 23793291 DOI: 10.1124/Mol.113.087080  0.682
2013 Kiss GN, Lee SC, Fells JI, Liu J, Valentine WJ, Fujiwara Y, Thompson KE, Yates CR, Sümegi B, Tigyi G. Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochimica Et Biophysica Acta. 1831: 117-25. PMID 23127512 DOI: 10.1016/J.Bbalip.2012.08.020  0.44
2013 Fells J, Lee SC, Norman D, Fujiwara Y, Tsukahara R, Liu J, Kirby J, Nelson S, Tigyi G. Abstract 5680: Identification and characterization of a novel class of ATX inhibitors. Cancer Research. 73: 5680-5680. DOI: 10.1158/1538-7445.Am2013-5680  0.409
2012 Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Molecular Pharmacology. 82: 1162-73. PMID 22968304 DOI: 10.1124/Mol.112.079699  0.704
2012 Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ. Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Biochemical Society Transactions. 40: 31-6. PMID 22260662 DOI: 10.1042/Bst20110608  0.375
2011 Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. Chemmedchem. 6: 922-35. PMID 21465666 DOI: 10.1002/Cmdc.201000425  0.754
2010 Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. 2D binary QSAR modeling of LPA3 receptor antagonism. Journal of Molecular Graphics & Modelling. 28: 828-33. PMID 20356772 DOI: 10.1016/J.Jmgm.2010.03.002  0.683
2009 Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Structure-based drug design identifies novel LPA3 antagonists. Bioorganic & Medicinal Chemistry. 17: 7457-64. PMID 19800804 DOI: 10.1016/J.Bmc.2009.09.022  0.698
2009 Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Research. 69: 5441-9. PMID 19509223 DOI: 10.1158/0008-5472.Can-09-0302  0.712
2009 Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. The Journal of Biological Chemistry. 284: 17304-19. PMID 19366702 DOI: 10.1074/Jbc.M109.003194  0.759
2008 Fells JI, Tsukahara R, Fujiwara Y, Liu J, Perygin DH, Osborne DA, Tigyi G, Parrill AL. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorganic & Medicinal Chemistry. 16: 6207-17. PMID 18467108 DOI: 10.1016/J.Bmc.2008.04.035  0.689
2008 Valentine WJ, Fells JI, Perygin DH, Mujahid S, Yokoyama K, Fujiwara Y, Tsukahara R, Van Brocklyn JR, Parrill AL, Tigyi G. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. The Journal of Biological Chemistry. 283: 12175-87. PMID 18316373 DOI: 10.1074/Jbc.M708847200  0.729
2008 Pham TC, Fells JI, Osborne DA, North EJ, Naor MM, Parrill AL. Molecular recognition in the sphingosine 1-phosphate receptor family. Journal of Molecular Graphics & Modelling. 26: 1189-201. PMID 18165127 DOI: 10.1016/J.Jmgm.2007.11.001  0.76
2004 Holdsworth G, Osborne DA, Pham TT, Fells JI, Hutchinson G, Milligan G, Parrill AL. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. Bmc Biochemistry. 5: 12. PMID 15298705 DOI: 10.1186/1471-2091-5-12  0.79
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