| Year |
Citation |
Score |
| 2019 |
Wu H, Castenheira P, Faro C, Tang J. Cardosin A Endocytosis Mediated by Integrin Leads to Lysosome Leakage and Apoptosis of Epithelial Cells. Proteins. PMID 30785216 DOI: 10.1002/Prot.25672 |
0.308 |
|
| 2019 |
Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. Chemmedchem. PMID 30637955 DOI: 10.1002/Cmdc.201800725 |
0.311 |
|
| 2018 |
Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. PMID 29970308 DOI: 10.1016/J.Bmcl.2018.06.045 |
0.311 |
|
| 2017 |
Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28427814 DOI: 10.1016/J.Bmcl.2017.04.011 |
0.322 |
|
| 2016 |
Chai S, Qian Y, Tang J, Liang Z, Zhang M, Si J, Li X, Huang W, Xu R, Wang K. Corrigendum to 'Ca(2+)/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer' [Cancer Lett. 344 (1), 119-128; March 1, 2014]. Cancer Letters. PMID 27491000 DOI: 10.1016/j.canlet.2016.07.026 |
0.333 |
|
| 2016 |
Tang JQ, Ma QF, Shi JT, Yuan HF, Song CF, Xie JC, Li XY. [Rapid FTIR-ATR Method for the Quantification of Bitumen Property]. Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu. 36: 672-5. PMID 27400503 |
0.323 |
|
| 2016 |
Li XL, Wu J, Tang J, Le Guennic B, Shi W, Cheng P. A planar triangular Dy3 + Dy3 single-molecule magnet with a toroidal magnetic moment. Chemical Communications (Cambridge, England). PMID 27388113 DOI: 10.1039/c6cc05326b |
0.328 |
|
| 2016 |
Li X, Liang L, De Vivo I, Tang JY, Han J. Pathway analysis of expression-related SNPs on genome-wide association study of basal cell carcinoma. Oncotarget. PMID 27367190 DOI: 10.18632/Oncotarget.9212 |
0.334 |
|
| 2016 |
Zhang Y, Tang J, Yang N, Liu Q, Zhang Q, Zhang Y, Li N, Zhao Y, Li S, Liu S, Zhou H, Li X, Tian M, Deng J, Xie P, et al. FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN. Journal of Immunology (Baltimore, Md. : 1950). PMID 27354218 DOI: 10.4049/Jimmunol.1501563 |
0.334 |
|
| 2016 |
Tang J, Yang R, Lv L, Yao A, Pu L, Yin A, Li X, Yu Y, Nyberg SL, Wang X. TGF-β-expressing Mesenchymal Stem Cells Induce Local Tolerance in a Rat Liver Transplantation Model of Acute Rejection. Stem Cells (Dayton, Ohio). PMID 27333806 DOI: 10.1002/stem.2437 |
0.341 |
|
| 2016 |
Xiao Z, Tang F, Tang J, Yang H, Zhao Y, Chen B, Han S, Wang N, Li X, Cheng S, Han G, Zhao C, Yang X, Chen Y, Shi Q, et al. One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Science China. Life Sciences. PMID 27333785 DOI: 10.1007/s11427-016-5080-z |
0.322 |
|
| 2016 |
Hu D, Li C, Sun L, Zhou C, Li X, Ai Z, Tang J, Peng A. A modified nontransposed brachiobasilic arteriovenous fistula versus brachiocephalic arteriovenous fistula for maintenance hemodialysis access. Journal of Vascular Surgery. PMID 27296523 DOI: 10.1016/j.jvs.2016.03.450 |
0.31 |
|
| 2016 |
Feng W, Li J, Han S, Tang J, Yao J, Cui Y, Wang C, Chen Z, Li X, Zhi X. [CT Guided Radiofrequency Ablation Followed Intratumoral Chemotherapy
in the Treatment of Early Stage Non-small Cell Lung Cancer]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer. 19: 269-78. PMID 27215455 DOI: 10.3779/j.issn.1009-3419.2016.05.04 |
0.313 |
|
| 2016 |
Wu J, Zhao L, Zhang L, Li XL, Guo M, Tang J. Metallosupramolecular Coordination Complexes: The Design of Heterometallic 3d-4f Gridlike Structures. Inorganic Chemistry. PMID 27195580 DOI: 10.1021/acs.inorgchem.6b00529 |
0.343 |
|
| 2016 |
Li X, Yin Y, Deng J, Zhong H, Tang J, Chen Z, Yang L, Ma LJ. A solvent-dependent fluorescent detection method for Fe(3+) and Hg(2+) based on a rhodamine B derivative. Talanta. 154: 329-34. PMID 27154682 DOI: 10.1016/j.talanta.2016.03.090 |
0.324 |
|
| 2016 |
Li GH, Luo B, Lv YX, Zheng F, Wang L, Wei MX, Li XY, Zhang L, Wang JN, Chen SY, Tang JM, He X. Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia-reperfusion injury. Journal of Translational Medicine. 14: 116. PMID 27146579 DOI: 10.1186/s12967-016-0847-3 |
0.322 |
|
| 2016 |
Wang L, Li M, Tang J, Li X. Eremophilane Sesquiterpenes from a Deep Marine-Derived Fungus, Aspergillus sp. SCSIOW2, Cultivated in the Presence of Epigenetic Modifying Agents. Molecules (Basel, Switzerland). 21. PMID 27096861 DOI: 10.3390/molecules21040473 |
0.371 |
|
| 2016 |
Yan J, Gopaul R, Wen J, Li XS, Tang JF. The natural progression of VGAMs and the need for urgent medical attention: a systematic review and meta-analysis. Journal of Neurointerventional Surgery. PMID 27091749 DOI: 10.1136/neurintsurg-2015-012212 |
0.315 |
|
| 2016 |
Lin H, Lin D, Long E, Jiang H, Qu B, Tang J, Lin Y, Chen J, Wu X, Lin Z, Li X, Liu Z, Zhang B, Chen H, Tan X, et al. Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China. Bmj Open. 6: e011061. PMID 27084286 DOI: 10.1136/bmjopen-2016-011061 |
0.304 |
|
| 2016 |
Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Notte GT, Kalla R, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Smith-Maxwell C, Dhalla AK, Rajamani S, Stafford B, ... Tang J, et al. Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine. Bioorganic & Medicinal Chemistry Letters. PMID 27080178 DOI: 10.1016/J.Bmcl.2016.03.101 |
0.373 |
|
| 2016 |
Li X, Li J, Wen H, Ju X, Chen X, Xia L, Ke G, Tang J, Wu X. The Survival Rate and Surgical Morbidity of Abdominal Radical Trachelectomy Versus Abdominal Radical Hysterectomy for Stage IB1 Cervical Cancer. Annals of Surgical Oncology. PMID 27044448 DOI: 10.1245/s10434-016-5216-1 |
0.3 |
|
| 2016 |
Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Hirakawa R, Smith-Maxwell C, Wu L, Dhalla AK, Rajamani S, Mollova N, ... Tang J, et al. Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. Bioorganic & Medicinal Chemistry Letters. PMID 27038498 DOI: 10.1016/j.bmcl.2016.03.096 |
0.361 |
|
| 2016 |
Wang D, Yang L, Zhu W, Zhang Y, Zou S, Bo H, Gao R, Dong J, Huang W, Guo J, Li Z, Zhao X, Li X, Xin L, Zhou J, ... ... Tang J, et al. Two outbreak sources of influenza A (H7N9) viruses have been established in China. Journal of Virology. PMID 27030268 DOI: 10.1128/JVI.03173-15 |
0.318 |
|
| 2016 |
Liang Y, Cao C, Zhu C, Wang C, Zhang C, Dong F, Yang F, Deng H, Yu J, Tang J, Su L, Xin L, Hong L, Gao M, Tang M, et al. The effectiveness and safety of amisulpride in Chinese patients with schizophrenia: An 8-week, prospective, open-label, multicenter, single-arm study. Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists. PMID 27020720 DOI: 10.1111/appy.12238 |
0.308 |
|
| 2016 |
Li Z, Wei W, Chen B, Cai G, Li X, Wang P, Tang J, Dong W. The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat. Scientific Reports. 6: 23508. PMID 27006085 DOI: 10.1038/srep23508 |
0.336 |
|
| 2016 |
Tang J, Li X, Luo Y, Li G, Khan S. Spectroscopic characterization of dissolved organic matter derived from different biochars and their polycylic aromatic hydrocarbons (PAHs) binding affinity. Chemosphere. 152: 399-406. PMID 26994600 DOI: 10.1016/j.chemosphere.2016.03.016 |
0.339 |
|
| 2016 |
Deng SL, Chen SR, Wang ZP, Zhang Y, Tang JX, Li J, Wang XX, Cheng JM, Jin C, Li XY, Zhang BL, Yu K, Lian ZX, Liu GS, Liu YX. Melatonin promotes development of haploid germ cells from early developing spermatogenic cells of Suffolk sheep under in vitro condition. Journal of Pineal Research. PMID 26993286 DOI: 10.1111/Jpi.12327 |
0.341 |
|
| 2016 |
Tang J, Wang J, Fan L, Li X, Liu N, Luo W, Wang J, Wang Y, Wang Y. cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer. Oncotarget. PMID 26992227 DOI: 10.18632/oncotarget.8079 |
0.35 |
|
| 2016 |
Li X, Tang Y, Yang J, Wen X, Guo J, Tang J, Du X, Su N, Chen L. Deletion of Fibroblast Growth Factor Receptor 3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26990430 DOI: 10.1002/jbmr.2839 |
0.332 |
|
| 2016 |
Li XY, Feng XZ, Tang JZ, Dong K, Wang JF, Meng CC, Wang J, Mo YW, Sun ZW. MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a. Molecular Medicine Reports. PMID 26986232 DOI: 10.3892/mmr.2016.4995 |
0.331 |
|
| 2016 |
Li X, Ding C, Liao J, Du L, Sun Q, Yang J, Yang Y, Zhang D, Tang J, Liu N. Bioaccumulation characterization of uranium by a novel Streptomyces sporoverrucosus dwc-3. Journal of Environmental Sciences (China). 41: 162-71. PMID 26969062 DOI: 10.1016/j.jes.2015.06.007 |
0.352 |
|
| 2016 |
Zhang C, Tang J, Liu D, Li X, Cheng L, Tang X. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. International Journal of Pharmaceutics. PMID 26943975 DOI: 10.1016/j.ijpharm.2016.02.045 |
0.346 |
|
| 2016 |
Li X, Ma Y, Chen T, Tang J, Ma X. [Unfractionated heparin inhibits lipopolysaccharide-induced expression of chemokines in human endothelial cells through nuclear factor-ΚB signaling pathway]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 28: 117-21. PMID 26911942 DOI: 10.3760/cma.j.issn.2095-4352.2016.02.007 |
0.333 |
|
| 2016 |
Zhao M, Deng Z, Tang J, Zhou X, Chen Z, Li X, Yang L, Ma LJ. 2-(1-Pyrenyl) benzimidazole as a ratiometric and "turn-on" fluorescent probe for iron(iii) ions in aqueous solution. The Analyst. PMID 26899673 DOI: 10.1039/c5an02565f |
0.315 |
|
| 2016 |
Tian JF, Li PJ, Li XX, Sun PH, Gao H, Liu XZ, Huang P, Tang JS, Yao XS. New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae. Bioorganic & Medicinal Chemistry Letters. PMID 26848110 DOI: 10.1016/j.bmcl.2016.01.074 |
0.358 |
|
| 2016 |
Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Schizophrenia Research. PMID 26822593 DOI: 10.1016/j.schres.2016.01.011 |
0.33 |
|
| 2016 |
Zhou M, Zhang Y, Li X, Wang Z, Tang J, Mu Y, Fang C, Chen X, Dai J. Complete genome sequence of Kocuria flava strain HO-9041, a heavy metal removal bacterium from Xinjiang. Journal of Biotechnology. PMID 26795688 DOI: 10.1016/j.jbiotec.2016.01.004 |
0.32 |
|
| 2016 |
Chen XG, Lv YX, Zhao D, Zhang L, Zheng F, Yang JY, Li XL, Wang L, Guo LY, Pan YM, Yan YW, Chen SY, Wang JN, Tang JM, Wan Y. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and Cellular Biochemistry. PMID 26769665 DOI: 10.1007/s11010-015-2622-9 |
0.343 |
|
| 2016 |
Lu R, Li X, Guo S, Wang H, Zhu J, He C, Li Q, Kang L, Wang Y, Tang J, Mu D. Neonatal mortality in the urban and rural China between 1996 and 2013: A retrospective study. Pediatric Research. PMID 26761125 DOI: 10.1038/pr.2016.6 |
0.32 |
|
| 2016 |
Wu H, He Z, Tang J, Li X, Cao H, Wang Y, Zheng SJ. A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release. Archives of Virology. PMID 26744063 DOI: 10.1007/s00705-015-2731-5 |
0.385 |
|
| 2016 |
Li X, Ma Y, Tang J, Chen T, Ma X. A Hemophagocytic Lymphohistiocytosis Patient that Presented With Unilateral Panuveitis. Ocular Immunology and Inflammation. 1-3. PMID 26731243 DOI: 10.3109/09273948.2015.1107593 |
0.306 |
|
| 2016 |
Liu X, Ma G, Zhao Z, Mao F, Tang J, Li X, Zhu M. Novel mutation of SLC20A2 in a Chinese family with primary familial brain calcification. Journal of the Neurological Sciences. 360: 1-3. PMID 26723961 DOI: 10.1016/j.jns.2015.11.036 |
0.319 |
|
| 2015 |
Ma X, Wang Q, Li X, Tang J, Zhang Z. Determination of the solubility parameter of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate by inverse gas chromatography. SE Pu = Chinese Journal of Chromatography / Zhongguo Hua Xue Hui. 33: 1192-8. PMID 26939366 |
0.338 |
|
| 2015 |
Tang J, Li X, Jiang X, Xu W, Xu Z, Wang W, Liu B, Lv Q, Zhang W. The association between rs9642880 gene polymorphism and bladder cancer risk: a meta-analysis. International Journal of Clinical and Experimental Medicine. 8: 20236-44. PMID 26884936 |
0.318 |
|
| 2015 |
Tang J, Li XY, Wu H, Ren LJ, Zhang YQ, Yao HX, Hu MB, Wang W. Tube-graft-Sheet Nano-Objects Created by A Stepwise Self-Assembly of Polymer-Polyoxometalate Hybrids. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 26710830 DOI: 10.1021/acs.langmuir.5b04504 |
0.339 |
|
| 2015 |
Cheng G, Hu R, Ye L, Wang B, Gui Y, Gao S, Li X, Tang J. Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. Aaps Pharmscitech. PMID 26694058 DOI: 10.1208/s12249-015-0469-8 |
0.339 |
|
| 2015 |
Wang WG, Li A, Yan BC, Niu SB, Tang JW, Li XN, Du X, Challis GL, Che Y, Sun HD, Pu JX. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18. Journal of Natural Products. PMID 26677752 DOI: 10.1021/acs.jnatprod.5b00814 |
0.367 |
|
| 2015 |
Tang JJ, Meng QY, Cai ZX, Li XQ. Transplantation of VEGFl65-overexpressing vascular endothelial progenitor cells relieves endothelial injury after deep vein thrombectomy. Thrombosis Research. PMID 26632512 DOI: 10.1016/j.thromres.2015.11.025 |
0.313 |
|
| 2015 |
Zhou M, Li XR, Tang JW, Liu Y, Li XN, Wu B, Qin HB, Du X, Li LM, Wang WG, Pu JX, Sun HD. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2 + 2] Cycloaddition and C-H Functionalization. Organic Letters. PMID 26617269 DOI: 10.1021/Acs.Orglett.5B03079 |
0.364 |
|
| 2015 |
Zhang Y, Yu C, Zhou M, Tang J, Li X, Wang Z, Li Z, Yao J, Li P, Zheng G, Chen X, Dai J. Complete Genome Sequence of Rufibacter tibetensis Strain 1351, a Radiation-resistant Bacterium from Tibet plateau. Journal of Biotechnology. PMID 26598420 DOI: 10.1016/j.jbiotec.2015.10.015 |
0.317 |
|
| 2015 |
Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. 25: 668-72. PMID 25537272 DOI: 10.1016/J.Bmcl.2014.11.087 |
0.323 |
|
| 2013 |
Li X, Hong L, Coughlan K, Wang L, Cao L, Tang J. Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease. Acta Biochimica Et Biophysica Sinica. 45: 613-21. PMID 23676825 DOI: 10.1093/Abbs/Gmt050 |
0.53 |
|
| 2013 |
Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochimica Et Biophysica Acta. 1833: 1562-71. PMID 23517619 DOI: 10.1016/J.Bbamcr.2013.03.003 |
0.54 |
|
| 2013 |
Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2132-44. PMID 23430844 DOI: 10.1096/Fj.12-214353 |
0.315 |
|
| 2012 |
Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 55: 9195-207. PMID 22954357 DOI: 10.1021/Jm3008823 |
0.338 |
|
| 2012 |
Ghosh AK, Pandey S, Gangarajula S, Kulkarni S, Xu X, Rao KV, Huang X, Tang J. Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 5460-5. PMID 22863204 DOI: 10.1016/J.Bmcl.2012.07.043 |
0.324 |
|
| 2012 |
Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Applied Microbiology and Biotechnology. 94: 1041-9. PMID 22270239 DOI: 10.1007/S00253-012-3893-7 |
0.342 |
|
| 2011 |
Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochemical and Biophysical Research Communications. 407: 400-5. PMID 21396916 DOI: 10.1016/J.Bbrc.2011.03.033 |
0.34 |
|
| 2010 |
Li X, Bo H, Zhang XC, Hartsuck JA, Tang J. Predicting memapsin 2 (β-secretase) hydrolytic activity. Protein Science : a Publication of the Protein Society. 19: 2175-85. PMID 20853423 DOI: 10.1002/Pro.502 |
0.504 |
|
| 2009 |
Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry. 52: 7689-705. PMID 19746963 DOI: 10.1021/Jm900695W |
0.338 |
|
| 2009 |
Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/J.Brainres.2009.01.008 |
0.341 |
|
| 2009 |
Marinkovic DV, Marinkovic JN, Tang J. Thermal fragmentation of Escherichia coli beta-galactosidase. Isolation and characterization of an alpha-complementing and two non-complementing polypeptide fractions. International Journal of Peptide and Protein Research. 8: 533-542. DOI: 10.1111/J.1399-3011.1976.Tb02533.X |
0.311 |
|
| 2008 |
Ghosh AK, Gemma S, Tang J. beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 399-408. PMID 18625451 DOI: 10.1016/J.Nurt.2008.05.007 |
0.343 |
|
| 2008 |
Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Memapsin 2 (beta-secretase) inhibitors: drug development. Current Alzheimer Research. 5: 121-31. PMID 18393797 DOI: 10.2174/156720508783954730 |
0.346 |
|
| 2008 |
Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorganic & Medicinal Chemistry Letters. 18: 1031-6. PMID 18180160 DOI: 10.1016/J.Bmcl.2007.12.028 |
0.368 |
|
| 2007 |
Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Current Alzheimer Research. 4: 418-22. PMID 17908045 DOI: 10.2174/156720507781788864 |
0.321 |
|
| 2007 |
Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. Journal of Medicinal Chemistry. 50: 2399-407. PMID 17432843 DOI: 10.1021/Jm061338S |
0.363 |
|
| 2007 |
He X, Cooley K, Chung CH, Dashti N, Tang J. Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4052-60. PMID 17428983 DOI: 10.1523/Jneurosci.3993-06.2007 |
0.749 |
|
| 2006 |
Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. Journal of the American Chemical Society. 128: 5310-1. PMID 16620080 DOI: 10.1021/Ja058636J |
0.349 |
|
| 2005 |
Ghosh AK, Kumaragurubaran N, Tang J. Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease. Current Topics in Medicinal Chemistry. 5: 1609-22. PMID 16375745 DOI: 10.2174/156802605775009711 |
0.377 |
|
| 2005 |
Tang J, He X, Huang X, Hong L. Recent developments on the studies of human memapsin 2 (beta-secretase). Current Alzheimer Research. 2: 261-4. PMID 15974927 DOI: 10.2174/1567205053585800 |
0.365 |
|
| 2005 |
Turner RT, Hong L, Koelsch G, Ghosh AK, Tang J. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry. 44: 105-12. PMID 15628850 DOI: 10.1021/Bi048106K |
0.418 |
|
| 2005 |
He X, Li F, Chang WP, Tang J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). The Journal of Biological Chemistry. 280: 11696-703. PMID 15615712 DOI: 10.1074/Jbc.M411296200 |
0.363 |
|
| 2005 |
Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorganic & Medicinal Chemistry Letters. 15: 15-20. PMID 15582402 DOI: 10.1016/J.Bmcl.2004.10.084 |
0.351 |
|
| 2004 |
Hong L, He X, Huang X, Chang W, Tang J. Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications. Acta Biochimica Et Biophysica Sinica. 36: 787-92. PMID 15592644 DOI: 10.1093/Abbs/36.12.787 |
0.374 |
|
| 2004 |
Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. The Embo Journal. 23: 3909-17. PMID 15457209 DOI: 10.1038/Sj.Emboj.7600411 |
0.353 |
|
| 2004 |
Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. Journal of Leukocyte Biology. 76: 1151-61. PMID 15345724 DOI: 10.1189/Jlb.0504300 |
0.322 |
|
| 2004 |
Huang XP, Chang WP, Koelsch G, Turner RT, Lupu F, Tang J. Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. The Journal of Biological Chemistry. 279: 37886-94. PMID 15197182 DOI: 10.1074/Jbc.M402130200 |
0.351 |
|
| 2004 |
Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors. Journal of Neurochemistry. 89: 1409-16. PMID 15189343 DOI: 10.1111/J.1471-4159.2004.02452.X |
0.342 |
|
| 2004 |
Hong L, Tang J. Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis. Biochemistry. 43: 4689-95. PMID 15096037 DOI: 10.1021/Bi0498252 |
0.332 |
|
| 2004 |
Fadeeva JV, Walsh DM, Tang J, Luo Y, Citron M, Wasco W, Selkoe DJ. P1-218 Generation of the intracellular C-terminal domain of the APP family of proteins does not require β-secretase Neurobiology of Aging. 25: S158. DOI: 10.1016/S0197-4580(04)80531-1 |
0.306 |
|
| 2003 |
Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. Biochemistry. 42: 13901-8. PMID 14636058 DOI: 10.1021/Bi035392B |
0.328 |
|
| 2003 |
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 42: 12174-80. PMID 14567678 DOI: 10.1021/Bi035199H |
0.405 |
|
| 2003 |
Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT, Chang W. Study of memapsin 2 (beta-secretase) and strategy of inhibitor design. Journal of Molecular Neuroscience : Mn. 20: 299-304. PMID 14501012 DOI: 10.1385/Jmn:20:3:299 |
0.334 |
|
| 2003 |
Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. Crystal structure of the human GGA1 GAT domain. Biochemistry. 42: 6392-9. PMID 12767220 DOI: 10.1021/Bi034334N |
0.362 |
|
| 2003 |
Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. Febs Letters. 537: 171-6. PMID 12606052 DOI: 10.1016/S0014-5793(03)00095-4 |
0.315 |
|
| 2003 |
Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. Crystal Structure of Human GGA1 GAT Domain Biochemistry. 42: 6392-6399. DOI: 10.2210/Pdb1J2H/Pdb |
0.302 |
|
| 2002 |
Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC. Effects of deletion of streptokinase residues 48-59 on plasminogen activation. Protein Engineering. 15: 753-61. PMID 12456874 DOI: 10.1093/Protein/15.9.753 |
0.779 |
|
| 2002 |
Hong L, Turner RT, Koelsch G, Shin D, Ghosh AK, Tang J. Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. Biochemistry. 41: 10963-7. PMID 12206667 DOI: 10.1021/Bi026232N |
0.377 |
|
| 2002 |
He X, Chang WP, Koelsch G, Tang J. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. Febs Letters. 524: 183-7. PMID 12135764 DOI: 10.1016/S0014-5793(02)03052-1 |
0.383 |
|
| 2002 |
Turner RT, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity. Biochemistry. 41: 8742-6. PMID 12093293 DOI: 10.1021/Bi025926T |
0.784 |
|
| 2002 |
Ghosh AK, Hong L, Tang J. Beta-secretase as a therapeutic target for inhibitor drugs. Current Medicinal Chemistry. 9: 1135-44. PMID 12052177 DOI: 10.2174/0929867023370149 |
0.368 |
|
| 2001 |
Loy JA, Lin X, Schenone M, Castellino FJ, Zhang XC, Tang J. Domain interactions between streptokinase and human plasminogen. Biochemistry. 40: 14686-95. PMID 11724583 DOI: 10.1021/Bi011309D |
0.782 |
|
| 2001 |
Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J. Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). Journal of Medicinal Chemistry. 44: 2865-8. PMID 11520194 DOI: 10.1021/Jm0101803 |
0.785 |
|
| 2001 |
Turner RT, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh aAK, Tang J. Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design† Biochemistry. 40: 10001-10006. PMID 11513577 DOI: 10.1021/Bi015546S |
0.326 |
|
| 2000 |
Ermolieff J, Loy JA, Koelsch G, Tang J. Proteolytic activation of recombinant pro-memapsin 2 (Pro-beta-secretase) studied with new fluorogenic substrates Biochemistry. 39: 16263. PMID 11123957 DOI: 10.1021/Bi005122I |
0.796 |
|
| 2000 |
Hong L, Zhang XC, Hartsuck JA, Tang J. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Science. 9: 1898-1904. PMID 11106162 DOI: 10.1110/Ps.9.10.1898 |
0.347 |
|
| 2000 |
Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science (New York, N.Y.). 290: 150-3. PMID 11021803 DOI: 10.1126/Science.290.5489.150 |
0.435 |
|
| 2000 |
Ermolieff J, Loy JA, Koelsch G, Tang J. Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates. Biochemistry. 39: 12450-6. PMID 11015226 DOI: 10.1021/bi001494f |
0.789 |
|
| 2000 |
Koelsch G, Tang J, Loy JA, Monod M, Jackson K, Foundling SI, Lin X. Enzymic characteristics of secreted aspartic proteases of Candida albicans. Biochimica Et Biophysica Acta. 1480: 117-31. PMID 11004559 DOI: 10.1016/S0167-4838(00)00068-6 |
0.774 |
|
| 2000 |
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 1456-1460. PMID 10677483 DOI: 10.1073/Pnas.97.4.1456 |
0.398 |
|
| 2000 |
Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. Journal of Molecular Biology. 295: 903-14. PMID 10656799 DOI: 10.1006/Jmbi.1999.3397 |
0.781 |
|
| 1999 |
Wang X, Tang J, Hunter B, Zhang XC. Crystal structure of streptokinase β-domain Febs Letters. 459: 85-89. PMID 10508922 DOI: 10.1016/S0014-5793(99)01214-4 |
0.365 |
|
| 1999 |
Faro C, Ramalho-Santos M, Vieira M, Mendes A, Simões I, Andrade R, Verı́ssimo P, Lin X, Tang J, Pires E. Cloning and Characterization of cDNA Encoding Cardosin A, an RGD-containing Plant Aspartic Proteinase Journal of Biological Chemistry. 274: 28724-28729. PMID 10497243 DOI: 10.1074/Jbc.274.40.28724 |
0.319 |
|
| 1998 |
Wang X, Lin X, Loy JA, Tang J, Zhang XC. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. Science (New York, N.Y.). 281: 1662-5. PMID 9733510 DOI: 10.1126/Science.281.5383.1662 |
0.778 |
|
| 1998 |
Faro C, Ramalho-Santos M, Veríssimo P, Pissarra J, Frazão C, Costa J, Lin X, Tang J, Pires E. Structural and Functional Aspects of Cardosins Advances in Experimental Medicine and Biology. 436: 423-433. PMID 9580379 DOI: 10.1007/978-1-4615-5373-1_58 |
0.319 |
|
| 1998 |
Koelsch G, Loy J, Lin X, Tang J. Activation mechanism of pepsinogen as compared to the processing of HIV protease gag-pol precursor protein. Advances in Experimental Medicine and Biology. 436: 245-52. PMID 9561226 DOI: 10.1007/978-1-4615-5373-1_34 |
0.769 |
|
| 1998 |
Hong L, Hartsuck JA, Foundling S, Ermolieff J, Tang J. Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant. Protein Science. 7: 300-305. PMID 9521105 DOI: 10.1002/Pro.5560070209 |
0.321 |
|
| 1997 |
Hong L, Zhang X, Foundling S, Hartsuck JA, Tang J. Structure Of A G48H Mutant Of Hiv-1 Protease Explains How Glycine-48 Replacements Produce Mutants Resistant To Inhibitor Drugs Febs Letters. 420: 11-16. PMID 9450540 DOI: 10.1016/S0014-5793(97)01477-4 |
0.337 |
|
| 1997 |
Wang X, Wang C, Tang J, Dyda F, Zhang XC. The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism. Structure. 5: 1209-1218. PMID 9331420 DOI: 10.1016/S0969-2126(97)00271-2 |
0.367 |
|
| 1996 |
Hong L, Treharne A, Hartsuck JA, Foundling S, Tang J. Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. Biochemistry. 35: 10627-10633. PMID 8718851 DOI: 10.1021/Bi960481S |
0.351 |
|
| 1995 |
Lin X, Tang J. Rearranging pepsinogen and pepsin by protein engineering. Advances in Experimental Medicine and Biology. 362: 33-40. PMID 8540337 DOI: 10.1007/978-1-4615-1871-6_4 |
0.337 |
|
| 1995 |
Lin X, Koelsch G, Loy JA, Tang J. Rearranging the domains of pepsinogen. Protein Science : a Publication of the Protein Society. 4: 159-66. PMID 7757006 DOI: 10.1002/Pro.5560040203 |
0.789 |
|
| 1995 |
Wang CS, Dashti A, Jackson KW, Yeh JC, Cummings RD, Tang J. Isolation and characterization of human milk bile salt-activated lipase C-tail fragment. Biochemistry. 34: 10639-44. PMID 7654718 DOI: 10.1021/Bi00033A039 |
0.318 |
|
| 1994 |
Co E, Koelsch G, Lin Y, Ido E, Hartsuck JA, Tang J. Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1. Biochemistry. 33: 1248-1254. PMID 8110758 DOI: 10.1021/Bi00171A027 |
0.313 |
|
| 1994 |
Downs D, Xu Y, Tang J, Wang C. Proline-rich domain and glycosylation are not essential for the enzymic activity of bile salt-activated lipase. Kinetic studies of T-BAL, a truncated form of the enzyme, expressed in Escherichia coli. Biochemistry. 33: 7979-7985. PMID 8025103 DOI: 10.1021/Bi00192A001 |
0.312 |
|
| 1994 |
Lin X, Lin Y, Tang J. Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases. Methods in Enzymology. 241: 195-224. PMID 7854179 DOI: 10.1016/0076-6879(94)41066-6 |
0.35 |
|
| 1994 |
Tang J, Lin X. Engineering aspartic proteases to probe structure and function relationships. Current Opinion in Biotechnology. 5: 422-427. PMID 7765175 DOI: 10.1016/0958-1669(94)90052-3 |
0.343 |
|
| 1993 |
Lin X, Loy JA, Sussman F, Tang J. Conformational instability of the N- and C-terminal lobes of porcine pepsin in neutral and alkaline solutions. Protein Science : a Publication of the Protein Society. 2: 1383-90. PMID 8401224 DOI: 10.1002/Pro.5560020903 |
0.771 |
|
| 1993 |
Trieu T, Behnke D, Gerlach D, Tang J. Activation of human plasminogen by recombinant staphylokinase. Methods in Enzymology. 223: 156-167. PMID 8271950 DOI: 10.1016/0076-6879(93)23043-M |
0.342 |
|
| 1991 |
Baba T, Downs D, Jackson KW, Tang J, Wang CS. Structure of human milk bile salt activated lipase. Biochemistry. 30: 500-510. PMID 1988041 DOI: 10.1021/Bi00216A028 |
0.326 |
|
| 1991 |
Lowther WT, Chen Z, Lin XL, Tang J, Dunn BM. Substrate specificity study of recombinant Rhizopus chinensis aspartic proteinase. Advances in Experimental Medicine and Biology. 306: 275-9. PMID 1812717 DOI: 10.1007/978-1-4684-6012-4_33 |
0.314 |
|
| 1991 |
Lin XL, Fusek M, Chen Z, Koelsch G, Han HP, Hartsuck JA, Tang J. Studies on Pepsin Mutagenesis and Recombinant Rhizopuspepsinogen Advances in Experimental Medicine and Biology. 306: 1-8. PMID 1812694 DOI: 10.1007/978-1-4684-6012-4_1 |
0.333 |
|
| 1987 |
Tang J, Wong RNS. Evolution in the structure and function of aspartic proteases Journal of Cellular Biochemistry. 33: 53-63. PMID 3546346 DOI: 10.1002/Jcb.240330106 |
0.367 |
|
| 1986 |
Jackson KW, Malke H, Gerlach D, Ferretti JJ, Tang J. Active streptokinase from the cloned gene in Streptococcus sanguis is without the carboxyl-terminal 32 residues Biochemistry. 25: 108-114. PMID 3954985 DOI: 10.1021/Bi00349A016 |
0.344 |
|
| 1982 |
Jackson KW, Tang J. Complete amino acid sequence of streptokinase and its homology with serine proteases. Biochemistry. 21: 6620-6625. PMID 6760891 DOI: 10.1021/Bi00269A001 |
0.353 |
|
| 1981 |
Jackson KW, Esmon N, Tang J. [31] Streptokinase and staphylokinase Methods in Enzymology. 80: 387-394. PMID 7043195 DOI: 10.1016/S0076-6879(81)80033-X |
0.315 |
|
| 1979 |
Tang J. Evolution in the structure and function of carboxyl proteases Molecular and Cellular Biochemistry. 26: 93-109. PMID 388185 DOI: 10.1007/Bf00232887 |
0.373 |
|
| 1977 |
Marciniszyn J, Hartsuck JA, Tang J. Pepstatin inhibition mechanism. Advances in Experimental Medicine and Biology. 95: 199-210. PMID 339690 DOI: 10.1007/978-1-4757-0719-9_12 |
0.307 |
|
| 1977 |
Hartsuck JA, Marciniszyn J, Huang JS, Tang J. Intramolecular Activation of Pepsinogen Advances in Experimental Medicine and Biology. 95: 85-102. PMID 22999 DOI: 10.1007/978-1-4757-0719-9_6 |
0.324 |
|
| 1975 |
Sepulveda P, Jackson KW, Tang J. The amino terminal sequences of acid proteases - human pepsin and gastricsin and the protease of Rhizopus chinensis☆ Biochemical and Biophysical Research Communications. 63: 1106-1112. PMID 236753 DOI: 10.1016/0006-291X(75)90683-X |
0.309 |
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