| Year |
Citation |
Score |
| 2014 |
Dingler FA, Kemmerich K, Neuberger MS, Rada C. Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation. European Journal of Immunology. 44: 1925-35. PMID 24771041 DOI: 10.1002/Eji.201444482 |
0.337 |
|
| 2014 |
Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α. Febs Letters. 588: 21-7. PMID 24269683 DOI: 10.1016/J.Febslet.2013.11.013 |
0.317 |
|
| 2013 |
Taylor BJ, Nik-Zainal S, Wu YL, Stebbings LA, Raine K, Campbell PJ, Rada C, Stratton MR, Neuberger MS. DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. Elife. 2: e00534. PMID 23599896 DOI: 10.7554/Elife.00534 |
0.314 |
|
| 2013 |
Chandra A, van Maldegem F, Andrews S, Neuberger MS, Rada C. Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice. Cell Cycle (Georgetown, Tex.). 12: 732-42. PMID 23343763 DOI: 10.4161/Cc.23594 |
0.356 |
|
| 2013 |
Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M. High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region. Journal of Immunology (Baltimore, Md. : 1950). 190: 1481-90. PMID 23303672 DOI: 10.4049/Jimmunol.1203041 |
0.342 |
|
| 2013 |
Nik-Zainal S, Taylor B, Wu YL, Wedge D, Rada C, Stratton M, Neuberger M. Abstract 611: AID/APOBEC cytidine deaminases can mimic the phenomenon of localized hypermutation in cancer orkataegis. Cancer Research. 73: 611-611. DOI: 10.1158/1538-7445.Am2013-611 |
0.309 |
|
| 2011 |
Uchimura Y, Barton LF, Rada C, Neuberger MS. REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase. The Journal of Experimental Medicine. 208: 2385-91. PMID 22042974 DOI: 10.1084/Jem.20110856 |
0.379 |
|
| 2011 |
Pruzina S, Williams GT, Kaneva G, Davies SL, MartÃn-López A, Brüggemann M, Vieira SM, Jeffs SA, Sattentau QJ, Neuberger MS. Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci. Protein Engineering, Design & Selection : Peds. 24: 791-9. PMID 21810921 DOI: 10.1093/Protein/Gzr038 |
0.392 |
|
| 2011 |
Ganesh K, Neuberger MS. The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1123-32. PMID 21454370 DOI: 10.1096/Fj.11-0402Ufm |
0.437 |
|
| 2011 |
Ganesh K, Adam S, Taylor B, Simpson P, Rada C, Neuberger M. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. The Journal of Biological Chemistry. 286: 17091-102. PMID 21385873 DOI: 10.1074/Jbc.M110.208769 |
0.329 |
|
| 2011 |
Wang M, Rada C, Neuberger MS. A high-throughput assay for DNA deaminases. Methods in Molecular Biology (Clifton, N.J.). 718: 171-84. PMID 21370049 DOI: 10.1007/978-1-61779-018-8_11 |
0.352 |
|
| 2010 |
Wang M, Rada C, Neuberger MS. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID. The Journal of Experimental Medicine. 207: 141-53. PMID 20048284 DOI: 10.1084/jem.20092238 |
0.356 |
|
| 2009 |
Langlois MA, Kemmerich K, Rada C, Neuberger MS. The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3. Journal of Virology. 83: 11550-9. PMID 19726503 DOI: 10.1128/Jvi.01430-09 |
0.315 |
|
| 2009 |
Wang M, Yang Z, Rada C, Neuberger MS. AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nature Structural & Molecular Biology. 16: 769-76. PMID 19543289 DOI: 10.1038/Nsmb.1623 |
0.358 |
|
| 2009 |
Geisberger R, Rada C, Neuberger MS. The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proceedings of the National Academy of Sciences of the United States of America. 106: 6736-41. PMID 19351893 DOI: 10.1073/Pnas.0810808106 |
0.309 |
|
| 2008 |
Takeda E, Tsuji-Kawahara S, Sakamoto M, Langlois MA, Neuberger MS, Rada C, Miyazawa M. Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo. Journal of Virology. 82: 10998-1008. PMID 18786991 DOI: 10.1128/Jvi.01311-08 |
0.375 |
|
| 2008 |
Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Molecular Cell. 31: 474-84. PMID 18722174 DOI: 10.1016/J.Molcel.2008.07.009 |
0.716 |
|
| 2008 |
Langlois MA, Neuberger MS. Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1. Journal of Virology. 82: 4660-4. PMID 18272574 DOI: 10.1128/Jvi.02469-07 |
0.342 |
|
| 2007 |
Di Noia JM, Williams GT, Chan DT, Buerstedde JM, Baldwin GS, Neuberger MS. Dependence of antibody gene diversification on uracil excision. The Journal of Experimental Medicine. 204: 3209-19. PMID 18070939 DOI: 10.1084/Jem.20071768 |
0.433 |
|
| 2007 |
Conticello SG, Langlois MA, Yang Z, Neuberger MS. DNA deamination in immunity: AID in the context of its APOBEC relatives. Advances in Immunology. 94: 37-73. PMID 17560271 DOI: 10.1016/S0065-2776(06)94002-4 |
0.694 |
|
| 2007 |
Di Noia JM, Neuberger MS. Molecular mechanisms of antibody somatic hypermutation. Annual Review of Biochemistry. 76: 1-22. PMID 17328676 DOI: 10.1146/annurev.biochem.76.061705.090740 |
0.366 |
|
| 2007 |
Conticello SG, Langlois MA, Neuberger MS. Insights into DNA deaminases. Nature Structural & Molecular Biology. 14: 7-9. PMID 17203067 DOI: 10.1038/Nsmb0107-7 |
0.665 |
|
| 2007 |
Neuberger MS, Rada C. Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T. The Journal of Experimental Medicine. 204: 7-10. PMID 17190841 DOI: 10.1084/Jem.20062409 |
0.338 |
|
| 2006 |
Xue K, Rada C, Neuberger MS. The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice. The Journal of Experimental Medicine. 203: 2085-94. PMID 16894013 DOI: 10.1084/Jem.20061067 |
0.403 |
|
| 2006 |
Di Noia JM, Rada C, Neuberger MS. SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. The Embo Journal. 25: 585-95. PMID 16407970 DOI: 10.1038/Sj.Emboj.7600939 |
0.451 |
|
| 2006 |
MacDuff DA, Neuberger MS, Harris RS. MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. Molecular Immunology. 43: 1099-108. PMID 16122802 DOI: 10.1016/J.Molimm.2005.07.024 |
0.464 |
|
| 2005 |
Mikl MC, Watt IN, Lu M, Reik W, Davies SL, Neuberger MS, Rada C. Mice deficient in APOBEC2 and APOBEC3. Molecular and Cellular Biology. 25: 7270-7. PMID 16055735 DOI: 10.1128/MCB.25.16.7270-7277.2005 |
0.307 |
|
| 2005 |
Langlois MA, Beale RC, Conticello SG, Neuberger MS. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Nucleic Acids Research. 33: 1913-23. PMID 15809227 DOI: 10.1093/Nar/Gki343 |
0.689 |
|
| 2005 |
Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nature Reviews. Immunology. 5: 171-8. PMID 15688043 DOI: 10.1038/Nri1553 |
0.333 |
|
| 2005 |
Conticello SG, Thomas CJ, Petersen-Mahrt SK, Neuberger MS. Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Molecular Biology and Evolution. 22: 367-77. PMID 15496550 DOI: 10.1093/Molbev/Msi026 |
0.717 |
|
| 2004 |
Rada C, Di Noia JM, Neuberger MS. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Molecular Cell. 16: 163-71. PMID 15494304 DOI: 10.1016/J.Molcel.2004.10.011 |
0.362 |
|
| 2004 |
Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. Journal of Molecular Biology. 337: 585-96. PMID 15019779 DOI: 10.1016/J.Jmb.2004.01.046 |
0.304 |
|
| 2004 |
Di Noia JM, Neuberger MS. Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. European Journal of Immunology. 34: 504-8. PMID 14768055 DOI: 10.1002/Eji.200324631 |
0.435 |
|
| 2003 |
Conticello SG, Harris RS, Neuberger MS. The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Current Biology : Cb. 13: 2009-13. PMID 14614829 DOI: 10.1016/J.Cub.2003.10.034 |
0.672 |
|
| 2003 |
Bemark M, Neuberger MS. By-products of immunoglobulin somatic hypermutation. Genes, Chromosomes & Cancer. 38: 32-9. PMID 12874784 DOI: 10.1002/Gcc.10241 |
0.421 |
|
| 2003 |
Neuberger MS, Harris RS, Di Noia J, Petersen-Mahrt SK. Immunity through DNA deamination. Trends in Biochemical Sciences. 28: 305-12. PMID 12826402 DOI: 10.1016/S0968-0004(03)00111-7 |
0.447 |
|
| 2003 |
Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH. DNA deamination mediates innate immunity to retroviral infection. Cell. 113: 803-9. PMID 12809610 DOI: 10.1016/S0092-8674(03)00423-9 |
0.317 |
|
| 2003 |
Petersen-Mahrt SK, Neuberger MS. In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). The Journal of Biological Chemistry. 278: 19583-6. PMID 12697753 DOI: 10.1074/Jbc.C300114200 |
0.39 |
|
| 2002 |
Harris RS, Petersen-Mahrt SK, Neuberger MS. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Molecular Cell. 10: 1247-53. PMID 12453430 DOI: 10.1016/S1097-2765(02)00742-6 |
0.383 |
|
| 2002 |
Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Current Biology : Cb. 12: 1748-55. PMID 12401169 DOI: 10.1016/S0960-9822(02)01215-0 |
0.361 |
|
| 2002 |
Cumbers SJ, Williams GT, Davies SL, Grenfell RL, Takeda S, Batista FD, Sale JE, Neuberger MS. Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines. Nature Biotechnology. 20: 1129-34. PMID 12379869 DOI: 10.1038/Nbt752 |
0.652 |
|
| 2002 |
Di Noia J, Neuberger MS. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature. 419: 43-8. PMID 12214226 DOI: 10.1038/Nature00981 |
0.425 |
|
| 2002 |
Neuberger MS. Novartis Medal Lecture. Antibodies: a paradigm for the evolution of molecular recognition. Biochemical Society Transactions. 30: 341-50. PMID 12196093 DOI: 10.1042/Bst0300341 |
0.459 |
|
| 2002 |
Petersen-Mahrt SK, Harris RS, Neuberger MS. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418: 99-103. PMID 12097915 DOI: 10.1038/Nature00862 |
0.44 |
|
| 2002 |
Neuberger M. César Milstein (1927–2002) Current Biology. 12. PMID 12007427 DOI: 10.1016/S0960-9822(02)00823-0 |
0.42 |
|
| 2002 |
Harris RS, Sale JE, Petersen-Mahrt SK, Neuberger MS. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Current Biology : Cb. 12: 435-8. PMID 11882297 DOI: 10.1016/S0960-9822(02)00717-0 |
0.655 |
|
| 2002 |
Lanoue A, Batista FD, Stewart M, Neuberger MS. Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity? European Journal of Immunology. 32: 348-55. PMID 11807774 DOI: 10.1002/1521-4141(200202)32:2<348::Aid-Immu348>3.0.Co;2-5 |
0.33 |
|
| 2001 |
Ehrenstein MR, Rada C, Jones AM, Milstein C, Neuberger MS. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 98: 14553-8. PMID 11717399 DOI: 10.1073/Pnas.241525998 |
0.337 |
|
| 2001 |
Harris RS, Croom-Carter DS, Rickinson AB, Neuberger MS. Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells. Journal of Virology. 75: 10488-92. PMID 11581418 DOI: 10.1128/Jvi.75.21.10488-10492.2001 |
0.377 |
|
| 2001 |
Sale JE, Calandrini DM, Takata M, Takeda S, Neuberger MS. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature. 412: 921-6. PMID 11528482 DOI: 10.1038/35091100 |
0.624 |
|
| 2001 |
Batista FD, Iber D, Neuberger MS. B cells acquire antigen from target cells after synapse formation. Nature. 411: 489-94. PMID 11373683 DOI: 10.1038/35078099 |
0.38 |
|
| 2001 |
Sale JE, Bemark M, Williams GT, Jolly CJ, Ehrenstein MR, Rada C, Milstein C, Neuberger MS. In vivo and in vitro studies of immunoglobulin gene somatic hypermutation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 21-8. PMID 11205326 DOI: 10.1098/Rstb.2000.0744 |
0.662 |
|
| 2001 |
Neuberger M. Antibody gene diversification by somatic hypermutation Biochemical Society Transactions. 29. DOI: 10.1042/Bst029A016C |
0.406 |
|
| 2000 |
Bemark M, Sale JE, Kim HJ, Berek C, Cosgrove RA, Neuberger MS. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. The Journal of Experimental Medicine. 192: 1509-14. PMID 11085752 DOI: 10.1084/Jem.192.10.1509 |
0.686 |
|
| 2000 |
Bemark M, Khamlichi AA, Davies SL, Neuberger MS. Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Current Biology : Cb. 10: 1213-6. PMID 11050391 DOI: 10.1016/S0960-9822(00)00724-7 |
0.364 |
|
| 2000 |
Williams GT, Jolly CJ, Köhler J, Neuberger MS. The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age. Immunity. 13: 409-17. PMID 11021538 DOI: 10.1016/S1074-7613(00)00040-6 |
0.376 |
|
| 2000 |
Neuberger MS, Scott J. Immunology. RNA editing AIDs antibody diversification? Science (New York, N.Y.). 289: 1705-6. PMID 11001738 DOI: 10.1126/Science.289.5485.1705 |
0.409 |
|
| 2000 |
Mary C, Laporte C, Parzy D, Santiago ML, Stefani F, Lajaunias F, Parkhouse RM, O'Keefe TL, Neuberger MS, Izui S, Reininger L. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 2987-96. PMID 10975807 DOI: 10.4049/Jimmunol.165.6.2987 |
0.306 |
|
| 2000 |
Neuberger MS, Sale JE, Cumbers SJ, Jolly CJ, Bemark MP, Ehrenstein MR, Lanoue A, Brüggemann M, Batista FD, Davies SL, Williams GT. Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system. Applied Biochemistry and Biotechnology. 83: 53-60; discussion 60. PMID 10826948 DOI: 10.1385/Abab:83:1-3:53 |
0.613 |
|
| 2000 |
Neuberger MS, Ehrenstein MR, Rada C, Sale J, Batista FD, Williams G, Milstein C. Memory in the B-cell compartment: antibody affinity maturation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355: 357-60. PMID 10794054 DOI: 10.1098/Rstb.2000.0573 |
0.671 |
|
| 2000 |
Ehrenstein MR, Cook HT, Neuberger MS. Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. The Journal of Experimental Medicine. 191: 1253-8. PMID 10748243 DOI: 10.1084/Jem.191.7.1253 |
0.377 |
|
| 2000 |
Batista FD, Neuberger MS. B cells extract and present immobilized antigen: implications for affinity discrimination. The Embo Journal. 19: 513-20. PMID 10675320 DOI: 10.1093/Emboj/19.4.513 |
0.37 |
|
| 1999 |
Neuberger MS, Lanoue A, Ehrenstein MR, Batista FD, Sale JE, Williams GT. Antibody diversification and selection in the mature B-cell compartment. Cold Spring Harbor Symposia On Quantitative Biology. 64: 211-6. PMID 11232288 DOI: 10.1101/Sqb.1999.64.211 |
0.625 |
|
| 1999 |
Ehrenstein MR, Neuberger MS. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. The Embo Journal. 18: 3484-90. PMID 10369687 DOI: 10.1093/Emboj/18.12.3484 |
0.421 |
|
| 1999 |
O'Keefe TL, Williams GT, Batista FD, Neuberger MS. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. The Journal of Experimental Medicine. 189: 1307-13. PMID 10209047 DOI: 10.1084/Jem.189.8.1307 |
0.391 |
|
| 1998 |
Sale JE, Neuberger MS. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity. 9: 859-69. PMID 9881976 DOI: 10.1016/S1074-7613(00)80651-2 |
0.655 |
|
| 1998 |
Ehrenstein MR, O'Keefe TL, Davies SL, Neuberger MS. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proceedings of the National Academy of Sciences of the United States of America. 95: 10089-93. PMID 9707605 DOI: 10.1073/Pnas.95.17.10089 |
0.416 |
|
| 1998 |
Rada C, Ehrenstein MR, Neuberger MS, Milstein C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity. 9: 135-41. PMID 9697843 DOI: 10.1016/S1074-7613(00)80595-6 |
0.334 |
|
| 1998 |
Milstein C, Neuberger MS, Staden R. Both DNA strands of antibody genes are hypermutation targets. Proceedings of the National Academy of Sciences of the United States of America. 95: 8791-4. PMID 9671757 DOI: 10.1073/Pnas.95.15.8791 |
0.411 |
|
| 1998 |
Batista FD, Neuberger MS. Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity. 8: 751-9. PMID 9655489 DOI: 10.1016/S1074-7613(00)80580-4 |
0.386 |
|
| 1998 |
O'Keefe TL, Williams GT, Davies SL, Neuberger MS. Mice carrying a CD20 gene disruption. Immunogenetics. 48: 125-32. PMID 9634476 DOI: 10.1007/S002510050412 |
0.339 |
|
| 1998 |
Neuberger MS, Ehrenstein MR, Klix N, Jolly CJ, Yélamos J, Rada C, Milstein C. Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunological Reviews. 162: 107-16. PMID 9602357 DOI: 10.1111/J.1600-065X.1998.Tb01434.X |
0.415 |
|
| 1998 |
Klix N, Jolly CJ, Davies SL, Brüggemann M, Williams GT, Neuberger MS. Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain. European Journal of Immunology. 28: 317-26. PMID 9485211 DOI: 10.1002/(Sici)1521-4141(199801)28:01<317::Aid-Immu317>3.0.Co;2-S |
0.344 |
|
| 1997 |
Goyenechea B, Klix N, Yélamos J, Williams GT, Riddell A, Neuberger MS, Milstein C. Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. The Embo Journal. 16: 3987-94. PMID 9233808 DOI: 10.1093/Emboj/16.13.3987 |
0.366 |
|
| 1997 |
Aluvihare VR, Khamlichi AA, Williams GT, Adorini L, Neuberger MS. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction. The Embo Journal. 16: 3553-62. PMID 9218797 DOI: 10.1093/Emboj/16.12.3553 |
0.377 |
|
| 1997 |
Teh YM, Neuberger MS. The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. The Journal of Experimental Medicine. 185: 1753-8. PMID 9151700 DOI: 10.1084/Jem.185.10.1753 |
0.412 |
|
| 1997 |
Jolly CJ, Klix N, Neuberger MS. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Research. 25: 1913-9. PMID 9115357 DOI: 10.1093/Nar/25.10.1913 |
0.46 |
|
| 1997 |
Neuberger M, Brüggemann M. Monoclonal antibodies. Mice perform a human repertoire. Nature. 386: 25-6. PMID 9052775 DOI: 10.1038/386025A0 |
0.354 |
|
| 1996 |
Wagner SD, Neuberger MS. Somatic hypermutation of immunoglobulin genes. Annual Review of Immunology. 14: 441-57. PMID 8962691 DOI: 10.1146/Annurev.Immunol.14.1.441 |
0.394 |
|
| 1996 |
Milstein C, Neuberger MS. Maturation of the immune response. Advances in Protein Chemistry. 49: 451-85. PMID 8908303 DOI: 10.1016/S0065-3233(08)60494-5 |
0.451 |
|
| 1996 |
O'Keefe TL, Williams GT, Davies SL, Neuberger MS. Hyperresponsive B cells in CD22-deficient mice. Science (New York, N.Y.). 274: 798-801. PMID 8864124 DOI: 10.1126/Science.274.5288.798 |
0.356 |
|
| 1996 |
Wagner SD, Gross G, Cook GP, Davies SL, Neuberger MS. Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones. Genomics. 35: 405-14. PMID 8812473 DOI: 10.1006/Geno.1996.0379 |
0.401 |
|
| 1996 |
Brüggemann M, Neuberger MS. Strategies for expressing human antibody repertoires in transgenic mice. Immunology Today. 17: 391-7. PMID 8783501 DOI: 10.1016/0167-5699(96)10025-6 |
0.402 |
|
| 1996 |
Jolly CJ, Wagner SD, Rada C, Klix N, Milstein C, Neuberger MS. The targeting of somatic hypermutation. Seminars in Immunology. 8: 159-68. PMID 8738915 DOI: 10.1006/Smim.1996.0020 |
0.406 |
|
| 1996 |
Wagner SD, Elvin JG, Norris P, McGregor JM, Neuberger MS. Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D). International Immunology. 8: 701-5. PMID 8671657 DOI: 10.1093/Intimm/8.5.701 |
0.392 |
|
| 1995 |
Cook GP, Meyer KB, Neuberger MS, Pettersson S. Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage. International Immunology. 7: 89-95. PMID 7718518 DOI: 10.1093/Intimm/7.1.89 |
0.322 |
|
| 1995 |
Yélamos J, Klix N, Goyenechea B, Lozano F, Chui YL, González Fernández A, Pannell R, Neuberger MS, Milstein C. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature. 376: 225-9. PMID 7617031 DOI: 10.1038/376225A0 |
0.403 |
|
| 1995 |
Neuberger MS, Milstein C. Somatic hypermutation. Current Opinion in Immunology. 7: 248-54. PMID 7546385 DOI: 10.1016/0952-7915(95)80010-7 |
0.303 |
|
| 1994 |
Williams GT, Peaker CJ, Patel KJ, Neuberger MS. The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment. Proceedings of the National Academy of Sciences of the United States of America. 91: 474-8. PMID 8290550 DOI: 10.1073/Pnas.91.2.474 |
0.306 |
|
| 1994 |
Wagner SD, Williams GT, Larson T, Neuberger MS, Kitamura D, Rajewsky K, Xian J, Brüggemann M. Antibodies generated from human immunoglobulin miniloci in transgenic mice. Nucleic Acids Research. 22: 1389-93. PMID 8190629 DOI: 10.1093/Nar/22.8.1389 |
0.574 |
|
| 1994 |
Betz AG, Milstein C, González-Fernández A, Pannell R, Larson T, Neuberger MS. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell. 77: 239-48. PMID 8168132 DOI: 10.1016/0092-8674(94)90316-6 |
0.395 |
|
| 1994 |
Wagner SD, Popov AV, Davies SL, Xian J, Neuberger MS, Brüggemann M. The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci European Journal of Immunology. 24: 2672-2681. PMID 7957560 DOI: 10.1002/Eji.1830241116 |
0.461 |
|
| 1994 |
González-Fernández A, Gupta SK, Pannell R, Neuberger MS, Milstein C. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proceedings of the National Academy of Sciences of the United States of America. 91: 12614-8. PMID 7809087 DOI: 10.1073/Pnas.91.26.12614 |
0.37 |
|
| 1993 |
Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proceedings of the National Academy of Sciences of the United States of America. 90: 2385-8. PMID 8460148 DOI: 10.1073/Pnas.90.6.2385 |
0.434 |
|
| 1993 |
Betz AG, Neuberger MS, Milstein C. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunology Today. 14: 405-11. PMID 8397780 DOI: 10.1016/0167-5699(93)90144-A |
0.422 |
|
| 1993 |
Patel KJ, Neuberger MS. Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines. Cell. 74: 939-46. PMID 8374958 DOI: 10.1016/0092-8674(93)90473-4 |
0.359 |
|
| 1993 |
Neuberger MS, Patel KJ, Dariavach P, Nelms K, Peaker CJ, Williams GT. The mouse B-cell antigen receptor: definition and assembly of the core receptor of the five immunoglobulin isotypes. Immunological Reviews. 132: 147-61. PMID 8349294 DOI: 10.1111/J.1600-065X.1993.Tb00841.X |
0.302 |
|
| 1993 |
Davies NP, Rosewell IR, Richardson JC, Cook GP, Neuberger MS, Brownstein BH, Norris ML, Brüggemann M. Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus. Bio/Technology (Nature Publishing Company). 11: 911-4. PMID 7763914 DOI: 10.1038/Nbt0893-911 |
0.414 |
|
| 1993 |
Peaker CJ, Neuberger MS. Association of CD22 with the B cell antigen receptor. European Journal of Immunology. 23: 1358-63. PMID 7684686 DOI: 10.1002/Eji.1830230626 |
0.325 |
|
| 1991 |
Sharpe MJ, Milstein C, Jarvis JM, Neuberger MS. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. The Embo Journal. 10: 2139-45. PMID 1905999 DOI: 10.1002/J.1460-2075.1991.Tb07748.X |
0.459 |
|
| 1991 |
Dariavach P, Williams GT, Campbell K, Pettersson S, Neuberger MS. The mouse IgH 3'-enhancer. European Journal of Immunology. 21: 1499-504. PMID 1904361 DOI: 10.1002/Eji.1830210625 |
0.384 |
|
| 1991 |
Brüggemann M, Neuberger MS. Generation of antibody repertoires in transgenic mice Methods. 2: 159-165. DOI: 10.1016/S1046-2023(05)80216-6 |
0.45 |
|
| 1990 |
Meyer KB, Sharpe MJ, Surani MA, Neuberger MS. The importance of the 3'-enhancer region in immunoglobulin kappa gene expression. Nucleic Acids Research. 18: 5609-15. PMID 2120679 DOI: 10.1093/Nar/18.19.5609 |
0.384 |
|
| 1990 |
Sharpe MJ, Neuberger M, Pannell R, Surani MA, Milstein C. Lack of somatic mutation in a kappa light chain transgene. European Journal of Immunology. 20: 1379-85. PMID 2115000 DOI: 10.1002/Eji.1830200625 |
0.437 |
|
| 1990 |
Sitia R, Neuberger M, Alberini C, Bet P, Fra A, Valetti C, Williams G, Milstein C. Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell. 60: 781-90. PMID 2107027 DOI: 10.1016/0092-8674(90)90092-S |
0.375 |
|
| 1990 |
Pettersson S, Cook GP, Brüggemann M, Williams GT, Neuberger MS. A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus. Nature. 344: 165-8. PMID 2106628 DOI: 10.1038/344165A0 |
0.388 |
|
| 1990 |
Williams GT, Venkitaraman AR, Gilmore DJ, Neuberger MS. The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface. The Journal of Experimental Medicine. 171: 947-52. PMID 2106568 DOI: 10.1084/Jem.171.3.947 |
0.316 |
|
| 1990 |
Biocca S, Neuberger M, Cattaneo A. Expression and targeting of intracellular antibodies in mammalian cells. The Embo Journal. 9: 101-108. DOI: 10.1002/J.1460-2075.1990.Tb08085.X |
0.419 |
|
| 1989 |
Neuberger MS, Cook GP. The expression of immunoglobulin genes. Immunology Today. 9: 278-81. PMID 3076426 DOI: 10.1016/0167-5699(88)91311-4 |
0.41 |
|
| 1989 |
Brüggemann M, Neuberger MS. Novel antibodies by DNA manipulation. Progress in Allergy. 45: 91-105. PMID 3064098 DOI: 10.1159/000318802 |
0.392 |
|
| 1989 |
Brüggemann M, Winter G, Waldmann H, Neuberger MS. The immunogenicity of chimeric antibodies. The Journal of Experimental Medicine. 170: 2153-7. PMID 2584938 DOI: 10.1084/Jem.170.6.2153 |
0.643 |
|
| 1989 |
Brüggemann M, Caskey HM, Teale C, Waldmann H, Williams GT, Surani MA, Neuberger MS. A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 86: 6709-13. PMID 2505258 DOI: 10.1073/Pnas.86.17.6709 |
0.405 |
|
| 1989 |
Neuberger MS, Caskey HM, Pettersson S, Williams GT, Surani MA. Isotype exclusion and transgene down-regulation in immunoglobulin-lambda transgenic mice. Nature. 338: 350-2. PMID 2493585 DOI: 10.1038/338350A0 |
0.379 |
|
| 1989 |
Meyer KB, Neuberger MS. The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. The Embo Journal. 8: 1959-1964. DOI: 10.1002/J.1460-2075.1989.Tb03601.X |
0.407 |
|
| 1988 |
Mason JO, Williams GT, Neuberger MS. The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. Genes & Development. 2: 1003-11. PMID 3139489 DOI: 10.1101/Gad.2.8.1003 |
0.35 |
|
| 1987 |
Bruggemann M, Williams GT, Bindon CI, Clark MR, Walker MR, Jefferis R, Waldmann H, Neuberger MS. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies Journal of Experimental Medicine. 166: 1351-1361. PMID 3500259 DOI: 10.1084/Jem.166.5.1351 |
0.399 |
|
| 1987 |
Sitia R, Neuberger MS, Milstein C. Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. The Embo Journal. 6: 3969-77. PMID 3127200 DOI: 10.1002/J.1460-2075.1987.Tb02739.X |
0.32 |
|
| 1987 |
Reik W, Williams G, Barton S, Norris M, Neuberger M, Surani MA. Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid-specific expression in transgenic mice. European Journal of Immunology. 17: 465-469. PMID 3106064 DOI: 10.1002/Eji.1830170405 |
0.381 |
|
| 1987 |
Cook GP, Mason JO, Neuberger MS. Chapter 6 Immunoglobulin gene expression New Comprehensive Biochemistry. 17: 153-176. DOI: 10.1016/S0167-7306(08)60158-1 |
0.368 |
|
| 1987 |
Cattaneo A, Neuberger MS. Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. The Embo Journal. 6: 2753-2758. DOI: 10.1002/J.1460-2075.1987.Tb02569.X |
0.371 |
|
| 1986 |
Williams GT, Neuberger MS. Production of antibody-tagged enzymes by myeloma cells: application to DNA polymerase I Klenow fragment. Gene. 43: 319-24. PMID 3744051 DOI: 10.1016/0378-1119(86)90223-4 |
0.419 |
|
| 1986 |
Jones PT, Dear PH, Foote J, Neuberger MS, Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321: 522-5. PMID 3713831 DOI: 10.1038/321522A0 |
0.667 |
|
| 1986 |
Neuberger MS, Williams GT. Construction of novel antibodies by use of DNA transfection: design of plasmid vectors Philosophical Transactions - Royal Society. Mathematical, Physical and Engineering Sciences. 317: 425-432. DOI: 10.1098/Rsta.1986.0052 |
0.448 |
|
| 1985 |
Mason JO, Williams GT, Neuberger MS. Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence. Cell. 41: 479-87. PMID 3921262 DOI: 10.1016/S0092-8674(85)80021-0 |
0.403 |
|
| 1985 |
Neuberger MS, Williams GT, Mitchell EB, Jouhal SS, Flanagan JG, Rabbitts TH. A hapten-specific chimaeric IgE antibody with human physiological effector function Nature. 314: 268-270. PMID 2580239 DOI: 10.1038/314268A0 |
0.419 |
|
| 1985 |
Neuberger MS. Making novel antibodies by expressing transfected immunoglobulin genes Trends in Biochemical Sciences. 10: 347-349. DOI: 10.1016/0968-0004(85)90109-4 |
0.43 |
|
| 1984 |
Neuberger MS, Williams GT, Fox RO. Recombinant antibodies possessing novel effector functions. Nature. 312: 604-8. PMID 6095112 DOI: 10.1038/312604A0 |
0.46 |
|
| 1983 |
Neuberger MS, Calabi F. Reciprocal chromosome translocation between c-myc and immunoglobulin gamma 2b genes. Nature. 305: 240-3. PMID 6412145 DOI: 10.1038/305240A0 |
0.353 |
|
| 1981 |
Neuberger MS, Rajewsky K. Activation of mouse complement by monoclonal mouse antibodies. European Journal of Immunology. 11: 1012-6. PMID 7327198 DOI: 10.1002/Eji.1830111212 |
0.505 |
|
| 1981 |
Neuberger MS, Rajewsky K. Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line. Proceedings of the National Academy of Sciences of the United States of America. 78: 1138-42. PMID 6940132 DOI: 10.1073/Pnas.78.2.1138 |
0.543 |
|
| 1981 |
Loviny T, Neuberger MS, Hartley BS. Sequence of a secondary phage lambda attachment site located between the pentitol operons of Klebsiella aerogenes. The Biochemical Journal. 193: 631-7. PMID 6458274 DOI: 10.1042/Bj1930631 |
0.542 |
|
| 1981 |
Neuberger MS, Hartley BS. Structure of an experimentally evolved gene duplication encoding ribitol dehydrogenase in a mutant of Klebsiella aerogenes. Journal of General Microbiology. 122: 181-91. PMID 6275000 DOI: 10.1099/00221287-122-2-181 |
0.581 |
|
| 1981 |
Neuberger MS, Hartley BS, Walker JE. Purification and properties of D-ribulokinase and D-xylulokinase from Klebsiella aerogenes. The Biochemical Journal. 193: 513-24. PMID 6272710 DOI: 10.1042/bj1930513 |
0.514 |
|
| 1980 |
Neuberger MS, Hartley BS. Minicircular ColE1-related DNA in strains of Klebsiella aerogenes selected for fast growth on xylitol. Journal of General Microbiology. 118: 171-7. PMID 6999122 DOI: 10.1099/00221287-118-1-171 |
0.554 |
|
| 1979 |
Neuberger MS, Patterson RA, Hartley BS. Purification and properties of Klebsiella aerogenes D-arabitol dehydrogenase. The Biochemical Journal. 183: 31-42. PMID 393250 |
0.518 |
|
| 1979 |
Neuberger MS, Hartley BS. Investigations into the Klebsiella aerogenes pentitol operons using specialised transducing phages lambdaprbt and lambdaprbt dal. Journal of Molecular Biology. 132: 435-70. PMID 230352 DOI: 10.1016/0022-2836(79)90269-9 |
0.596 |
|
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