| Year |
Citation |
Score |
| 2023 |
Zangerl-Plessl EM, Wu W, Sanguinetti MC, Stary-Weinzinger A. Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate. Frontiers in Molecular Biosciences. 10: 1137368. PMID 36911523 DOI: 10.3389/fmolb.2023.1137368 |
0.608 |
|
| 2022 |
Sanguinetti MC, Seebohm G. Physiological Functions, Biophysical Properties, and Regulation of KCNQ1 (K7.1) Potassium Channels. Advances in Experimental Medicine and Biology. 1349: 335-353. PMID 35138621 DOI: 10.1007/978-981-16-4254-8_15 |
0.551 |
|
| 2020 |
Crotti L, Odening KE, Sanguinetti MC. Heritable arrhythmias associated with abnormal function of cardiac potassium channels. Cardiovascular Research. PMID 32227190 DOI: 10.1093/Cvr/Cvaa068 |
0.617 |
|
| 2019 |
Zangerl-Plessl EM, Berger M, Drescher M, Chen Y, Wu W, Maulide N, Sanguinetti M, Stary-Weinzinger A. Towards a structural view of hERG activation by the small molecule activator ICA-105574. Journal of Chemical Information and Modeling. PMID 31877041 DOI: 10.1021/Acs.Jcim.9B00737 |
0.602 |
|
| 2019 |
Attali B, Chandy KG, Giese MH, Grissmer S, Gutman GA, Jan LY, Lazdunski M, Mckinnon D, Nerbonne J, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Trimmer JS, et al. Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f81/2019.4 |
0.58 |
|
| 2018 |
Garg P, Garg V, Shrestha R, Sanguinetti MC, Kamp TJ, Wu JC. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Models for Cardiac Channelopathies: A Primer for Non-Electrophysiologists. Circulation Research. 123: 224-243. PMID 29976690 DOI: 10.1161/Circresaha.118.311209 |
0.645 |
|
| 2018 |
Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JC. Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant. Journal of the American College of Cardiology. 72: 62-75. PMID 29957233 DOI: 10.1016/J.Jacc.2018.04.041 |
0.503 |
|
| 2017 |
Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti M. Molecular basis of altered hERG1 channel gating induced by ginsenoside Rg3. Molecular Pharmacology. PMID 28705808 DOI: 10.1124/mol.117.108886 |
0.625 |
|
| 2016 |
Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. The Journal of Physiology. PMID 27861921 DOI: 10.1113/Jp272864 |
0.605 |
|
| 2016 |
Thomson SJ, Hansen A, Sanguinetti MC. Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels. The Journal of Biological Chemistry. 291: 21423. PMID 27825078 DOI: 10.1074/Jbc.A114.582437 |
0.54 |
|
| 2016 |
Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, et al. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology. PMID 27808412 DOI: 10.1113/Jp272883 |
0.515 |
|
| 2016 |
Giese MH, Gardner A, Hansen A, Sanguinetti MC. Molecular mechanisms of Slo2 K(+) channel closure. The Journal of Physiology. PMID 27682982 DOI: 10.1113/Jp273225 |
0.781 |
|
| 2016 |
Wu W, Gardner A, Sachse F, Sanguinetti M. Ginsenoside Rg3, a gating modifier of EAG family K+ channels. Molecular Pharmacology. PMID 27502018 DOI: 10.1124/Mol.116.104091 |
0.675 |
|
| 2016 |
Wu W, Sanguinetti MC. Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology. Cardiac Electrophysiology Clinics. 8: 275-84. PMID 27261821 DOI: 10.1016/J.Ccep.2016.01.002 |
0.675 |
|
| 2016 |
Wu W, Gardner A, Sanguinetti M. Ginsenoside Rg3 Activates Human EAG Family of K+ Channels via Allosteric Modification of Gating Biophysical Journal. 110: 278a. DOI: 10.1016/J.Bpj.2015.11.1508 |
0.671 |
|
| 2015 |
Suzuki T, Hansen A, Sanguinetti MC. Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels. Biochimica Et Biophysica Acta. PMID 26724206 DOI: 10.1016/J.Bbamem.2015.12.024 |
0.661 |
|
| 2015 |
Thomson SJ, Hansen A, Sanguinetti MC. Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels. The Journal of Biological Chemistry. 290: 14528-35. PMID 25903137 DOI: 10.1074/Jbc.M115.653089 |
0.65 |
|
| 2015 |
Gardner A, Sanguinetti MC. C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation. Molecular Pharmacology. 88: 19-28. PMID 25888115 DOI: 10.1124/Mol.115.098384 |
0.645 |
|
| 2015 |
Wu W, Gardner A, Sanguinetti MC. The Link between Inactivation and High-Affinity Block of hERG1 Channels. Molecular Pharmacology. 87: 1042-50. PMID 25855787 DOI: 10.1124/Mol.115.098111 |
0.642 |
|
| 2015 |
Wu W, Gardner A, Sanguinetti MC. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Molecular Pharmacology. 87: 401-9. PMID 25519838 DOI: 10.1124/Mol.114.096693 |
0.661 |
|
| 2015 |
Thomson SJ, Hansen A, Sanguinetti MC. Identification of the intracellular Na+ sensor in Slo2.1 potassium channels Journal of Biological Chemistry. 290: 14528-14535. DOI: 10.1074/jbc.M115.653089 |
0.412 |
|
| 2015 |
Wu W, Gardner A, Sachse F, Sanguinetti M. Stoichiometry of a hERG1 Agonist on Channel Gating Biophysical Journal. 108: 121a. DOI: 10.1016/J.Bpj.2014.11.679 |
0.628 |
|
| 2015 |
Thomson SJ, Sanguinetti MC. Mechanisms of Activation of Slo2.1 Channels by Intracellular Na+ Biophysical Journal. 108: 289a-290a. DOI: 10.1016/J.Bpj.2014.11.1580 |
0.669 |
|
| 2014 |
Garg P, Sanguinetti MC. Intracellular ATP does not inhibit Slo2.1 K+ channels. Physiological Reports. 2. PMID 25214519 DOI: 10.14814/Phy2.12118 |
0.759 |
|
| 2014 |
Wu W, Gardner A, Sanguinetti MC. Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels. The Journal of Physiology. 592: 4465-80. PMID 25063820 DOI: 10.1113/Jphysiol.2014.277483 |
0.634 |
|
| 2014 |
Thomson SJ, Hansen A, Sanguinetti MC. Concerted all-or-none subunit interactions mediate slow deactivation of human ether-Ã -go-go-related gene K+ channels. The Journal of Biological Chemistry. 289: 23428-36. PMID 25008322 DOI: 10.1074/Jbc.M114.582437 |
0.663 |
|
| 2014 |
Sanguinetti MC. HERG1 channel agonists and cardiac arrhythmia. Current Opinion in Pharmacology. 15: 22-7. PMID 24721650 DOI: 10.1016/J.Coph.2013.11.006 |
0.619 |
|
| 2014 |
Wu W, Sachse FB, Gardner A, Sanguinetti MC. Stoichiometry of altered hERG1 channel gating by small molecule activators. The Journal of General Physiology. 143: 499-512. PMID 24638994 DOI: 10.1085/Jgp.201311038 |
0.628 |
|
| 2014 |
Thomson SJ, Hansen A, Sanguinetti MC. N-Terminal Regulation of hERG1 K+ Channel Deactivation Biophysical Journal. 106: 15a. DOI: 10.1016/J.Bpj.2013.11.138 |
0.559 |
|
| 2013 |
Garg P, Gardner A, Garg V, Sanguinetti MC. Structural basis of ion permeation gating in Slo2.1 K+ channels. The Journal of General Physiology. 142: 523-42. PMID 24166878 DOI: 10.1085/Jgp.201311064 |
0.767 |
|
| 2013 |
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nature Chemical Biology. 9: 507-13. PMID 23728494 DOI: 10.1038/Nchembio.1271 |
0.577 |
|
| 2013 |
Garg V, Stary-Weinzinger A, Sanguinetti MC. ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Molecular Pharmacology. 83: 805-13. PMID 23319419 DOI: 10.1124/Mol.112.084384 |
0.653 |
|
| 2013 |
Garg V, Stary-Weinzinger A, Sanguinetti MC. Inactivation Properties, not Binding Site Differences, Govern Reciprocal Functional Response to ICA105574 in EAG and ERG Potassium Channels Biophysical Journal. 104: 266a. DOI: 10.1016/J.Bpj.2012.11.1494 |
0.618 |
|
| 2013 |
Sanguinetti MC, Tristani-Firouzi M, Sachse FB. Structural Determinants and Biophysical Properties of hERG1 Channel Gating Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition. 121-128. DOI: 10.1016/B978-1-4557-2856-5.00012-1 |
0.514 |
|
| 2012 |
Garg V, Sachse FB, Sanguinetti MC. Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule. The Journal of General Physiology. 140: 307-24. PMID 22930803 DOI: 10.1085/Jgp.201210826 |
0.693 |
|
| 2012 |
Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC. Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels. Chemical Research in Toxicology. 25: 1975-84. PMID 22856456 DOI: 10.1021/Tx300283T |
0.662 |
|
| 2012 |
Garg P, Sanguinetti MC. Structure-activity relationship of fenamates as Slo2.1 channel activators. Molecular Pharmacology. 82: 795-802. PMID 22851714 DOI: 10.1124/Mol.112.079194 |
0.694 |
|
| 2012 |
Garg P, Sanguinetti M. Pharmacology of Slo2.1 Channel Activation and Block Biophysical Journal. 102: 137a. DOI: 10.1016/J.Bpj.2011.11.757 |
0.755 |
|
| 2012 |
Garg V, Sanguinetti M. Modulation of EAG Channel Inactivation by ICA105574 Biophysical Journal. 102: 132a. DOI: 10.1016/J.Bpj.2011.11.732 |
0.634 |
|
| 2012 |
Garg V, Stary-Weinzinger A, Sanguinetti MC. ICA105574 Binds to a Similar Region of the Pore Domain to Induce Opposite Effects on the Gating of EAG and ERG Channels Biophysical Journal. 102: 132a. DOI: 10.1016/J.Bpj.2011.11.731 |
0.661 |
|
| 2011 |
Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC. Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide. Molecular Pharmacology. 80: 630-7. PMID 21743002 DOI: 10.1124/Mol.111.073809 |
0.65 |
|
| 2011 |
Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC. Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Molecular Pharmacology. 79: 1-9. PMID 20876384 DOI: 10.1124/Mol.110.067728 |
0.67 |
|
| 2011 |
Garg V, Sachse F, Sanguinetti M. Structural Basis of Action for a Novel hERG1 Channel Activator Biophysical Journal. 100: 102a-103a. DOI: 10.1016/J.Bpj.2010.12.767 |
0.658 |
|
| 2010 |
Abbruzzese J, Sachse FB, Tristani-Firouzi M, Sanguinetti MC. Modification of hERG1 channel gating by Cd2+. The Journal of General Physiology. 136: 203-24. PMID 20660661 DOI: 10.1085/Jgp.201010450 |
0.464 |
|
| 2010 |
Perry M, Sanguinetti M, Mitcheson J. Revealing the structural basis of action of hERG potassium channel activators and blockers. The Journal of Physiology. 588: 3157-67. PMID 20643767 DOI: 10.1113/Jphysiol.2010.194670 |
0.658 |
|
| 2010 |
Sanguinetti MC. HERG1 channelopathies. PflüGers Archiv : European Journal of Physiology. 460: 265-76. PMID 20544339 DOI: 10.1007/s00424-009-0758-8 |
0.501 |
|
| 2010 |
Du YM, Zhang XX, Tu DN, Zhao N, Liu YJ, Xiao H, Sanguinetti MC, Zou A, Liao YH. Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1. Journal of Molecular and Cellular Cardiology. 48: 1111-20. PMID 20184887 DOI: 10.1016/J.Yjmcc.2010.02.010 |
0.673 |
|
| 2010 |
Dai L, Garg V, Sanguinetti MC. Activation of Slo2.1 channels by niflumic acid. The Journal of General Physiology. 135: 275-95. PMID 20176855 DOI: 10.1085/Jgp.200910316 |
0.601 |
|
| 2009 |
Perry M, Sachse FB, Abbruzzese J, Sanguinetti MC. PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance. Proceedings of the National Academy of Sciences of the United States of America. 106: 20075-80. PMID 19892732 DOI: 10.1073/Pnas.0906597106 |
0.595 |
|
| 2009 |
Cheng L, Sanguinetti MC. Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains. Molecular Pharmacology. 75: 1210-21. PMID 19218366 DOI: 10.1124/Mol.108.054437 |
0.666 |
|
| 2009 |
Perry MD, Sanguinetti MC. Mechanism Of Action For The hERG Potassium Channel Activator, PD-118057 Biophysical Journal. 96: 188a. DOI: 10.1016/J.Bpj.2008.12.882 |
0.509 |
|
| 2009 |
Dai L, Sanguinetti M. Role of Charged Residues in the S1-S4 Domains of Slo2.1 K+ Channels Biophysical Journal. 96: 482a. DOI: 10.1016/J.Bpj.2008.12.2485 |
0.629 |
|
| 2008 |
Brown S, Sonntag DP, Sanguinetti MC. A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 22: 601-10. PMID 19088442 DOI: 10.1159/000185544 |
0.666 |
|
| 2008 |
Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, ... ... Sanguinetti MC, et al. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels. Circulation Research. 103: 1451-7. PMID 19008479 DOI: 10.1161/Circresaha.108.177360 |
0.606 |
|
| 2008 |
Decher N, Gonzalez T, Streit AK, Sachse FB, Renigunta V, Soom M, Heinemann SH, Daut J, Sanguinetti MC. Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. The Embo Journal. 27: 3164-74. PMID 18987637 DOI: 10.1038/Emboj.2008.231 |
0.624 |
|
| 2008 |
Kamiya K, Niwa R, Morishima M, Honjo H, Sanguinetti MC. Molecular determinants of hERG channel block by terfenadine and cisapride. Journal of Pharmacological Sciences. 108: 301-7. PMID 18987434 DOI: 10.1254/Jphs.08102Fp |
0.616 |
|
| 2008 |
Rosati B, Dong M, Cheng L, Liou SR, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang HS, McKinnon D. Evolution of ventricular myocyte electrophysiology. Physiological Genomics. 35: 262-72. PMID 18765860 DOI: 10.1016/J.Bpj.2008.12.3691 |
0.495 |
|
| 2008 |
Restier L, Cheng L, Sanguinetti MC. Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels. The Journal of Physiology. 586: 4179-91. PMID 18599533 DOI: 10.1113/Jphysiol.2008.157511 |
0.662 |
|
| 2008 |
Fernandez D, Sargent J, Sachse FB, Sanguinetti MC. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Molecular Pharmacology. 73: 1159-67. PMID 18218980 DOI: 10.1124/Mol.107.043505 |
0.675 |
|
| 2008 |
Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M. Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 21: 37-46. PMID 18209470 DOI: 10.1159/000113745 |
0.56 |
|
| 2008 |
Perry M, Sanguinetti MC. A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Molecular Pharmacology. 73: 1044-51. PMID 18162604 DOI: 10.1124/Mol.107.043018 |
0.655 |
|
| 2007 |
Perry M, Sachse FB, Sanguinetti MC. Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator. Proceedings of the National Academy of Sciences of the United States of America. 104: 13827-32. PMID 17693551 DOI: 10.1073/Pnas.0703934104 |
0.699 |
|
| 2007 |
Cheng L, Kinard K, Rajamani R, Sanguinetti MC. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. The Journal of Pharmacology and Experimental Therapeutics. 322: 931-9. PMID 17578902 DOI: 10.1124/Jpet.107.121467 |
0.688 |
|
| 2007 |
Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann SH, Timothy KW, Keating MT, Daut J, Sanguinetti MC, Splawski I. Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovascular Research. 75: 748-57. PMID 17568571 DOI: 10.1016/J.Cardiores.2007.05.010 |
0.54 |
|
| 2007 |
Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, ... Sanguinetti MC, et al. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circulation Research. 100: 686-92. PMID 17293474 DOI: 10.1161/01.Res.0000260250.83824.8F |
0.455 |
|
| 2007 |
Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y, Guerchicoff A, Pfeiffer R, Oliva A, Wollnik B, Gelber P, Bonaros EP, Burashnikov E, Wu Y, Sargent JD, et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation. 115: 442-9. PMID 17224476 DOI: 10.1161/Circulationaha.106.668392 |
0.386 |
|
| 2006 |
Decher N, Kumar P, Gonzalez T, Pirard B, Sanguinetti MC. Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation. Molecular Pharmacology. 70: 1204-11. PMID 16835355 DOI: 10.1124/Mol.106.026203 |
0.6 |
|
| 2006 |
Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature. 440: 463-9. PMID 16554806 DOI: 10.1038/Nature04710 |
0.64 |
|
| 2006 |
Kamiya K, Niwa R, Mitcheson JS, Sanguinetti MC. Molecular determinants of HERG channel block. Molecular Pharmacology. 69: 1709-16. PMID 16474003 DOI: 10.1124/Mol.105.020990 |
0.676 |
|
| 2006 |
Seebohm G, Strutz-Seebohm N, Ureche ON, Baltaev R, Lampert A, Kornichuk G, Kamiya K, Wuttke TV, Lerche H, Sanguinetti MC, Lang F. Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophysical Journal. 90: 2235-44. PMID 16326905 DOI: 10.1529/Biophysj.105.067165 |
0.663 |
|
| 2006 |
Casis O, Olesen SP, Sanguinetti MC. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Molecular Pharmacology. 69: 658-65. PMID 16284303 DOI: 10.1124/Mol.105.019943 |
0.684 |
|
| 2005 |
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacological Reviews. 57: 473-508. PMID 16382104 DOI: 10.1124/pr.57.4.10 |
0.526 |
|
| 2005 |
Hong K, Piper DR, Diaz-Valdecantos A, Brugada J, Oliva A, Burashnikov E, Santos-de-Soto J, Grueso-Montero J, Diaz-Enfante E, Brugada P, Sachse F, Sanguinetti MC, Brugada R. De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovascular Research. 68: 433-40. PMID 16109388 DOI: 10.1016/J.Cardiores.2005.06.023 |
0.431 |
|
| 2005 |
Sanguinetti MC, Chen J, Fernandez D, Kamiya K, Mitcheson J, Sanchez-Chapula JA. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs. Novartis Foundation Symposium. 266: 159-66; discussion 1. PMID 16050267 DOI: 10.1002/047002142X.Ch13 |
0.547 |
|
| 2005 |
Mitcheson J, Perry M, Stansfeld P, Sanguinetti MC, Witchel H, Hancox J. Structural determinants for high-affinity block of hERG potassium channels. Novartis Foundation Symposium. 266: 136-50; discussion 1. PMID 16050266 DOI: 10.1002/047002142X.Ch11 |
0.668 |
|
| 2005 |
Piper DR, Sanguinetti MC, Tristani-Firouzi M. Voltage sensor movement in the hERG K+ channel. Novartis Foundation Symposium. 266: 46-52; discussion 52. PMID 16050261 DOI: 10.1002/047002142X.Ch5 |
0.623 |
|
| 2005 |
Decher N, Kumar P, Gonzalez T, Renigunta V, Sanguinetti MC. Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels. Molecular Pharmacology. 68: 995-1005. PMID 16024663 DOI: 10.1124/Mol.105.011668 |
0.545 |
|
| 2005 |
Fernandez D, Ghanta A, Kinard KI, Sanguinetti MC. Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation. The Journal of Physiology. 567: 737-55. PMID 15975984 DOI: 10.1113/Jphysiol.2005.089094 |
0.509 |
|
| 2005 |
Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences of the United States of America. 102: 8089-96; discussion . PMID 15863612 DOI: 10.1073/Pnas.0502506102 |
0.445 |
|
| 2005 |
Sanguinetti MC, Mitcheson JS. Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends in Pharmacological Sciences. 26: 119-24. PMID 15749156 DOI: 10.1016/J.Tips.2005.01.003 |
0.622 |
|
| 2005 |
Seebohm G, Westenskow P, Lang F, Sanguinetti MC. Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels. The Journal of Physiology. 563: 359-68. PMID 15649981 DOI: 10.1113/Jphysiol.2004.080887 |
0.674 |
|
| 2005 |
Piper DR, Hinz WA, Tallurri CK, Sanguinetti MC, Tristani-Firouzi M. Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating. The Journal of Biological Chemistry. 280: 7206-17. PMID 15528201 DOI: 10.1074/Jbc.M411042200 |
0.541 |
|
| 2004 |
Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC. Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine. Naunyn-Schmiedeberg's Archives of Pharmacology. 370: 484-91. PMID 15558243 DOI: 10.1007/S00210-004-0995-5 |
0.671 |
|
| 2004 |
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell. 119: 19-31. PMID 15454078 DOI: 10.1016/J.Cell.2004.09.011 |
0.401 |
|
| 2004 |
Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC, Mitcheson J. Structural determinants of HERG channel block by clofilium and ibutilide. Molecular Pharmacology. 66: 240-9. PMID 15266014 DOI: 10.1124/Mol.104.000117 |
0.575 |
|
| 2004 |
Decher N, Barth AS, Gonzalez T, Steinmeyer K, Sanguinetti MC. Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents. The Journal of Physiology. 557: 761-72. PMID 15107477 DOI: 10.1113/Jphysiol.2004.066720 |
0.574 |
|
| 2004 |
Fenichel RR, Malik M, Antzelevitch C, Sanguinetti M, Roden DM, Priori SG, Ruskin JN, Lipicky RJ, Cantilena LR. Drug-induced torsades de pointes and implications for drug development. Journal of Cardiovascular Electrophysiology. 15: 475-95. PMID 15090000 DOI: 10.1046/J.1540-8167.2004.03534.X |
0.309 |
|
| 2004 |
Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC. Compound mutations: a common cause of severe long-QT syndrome. Circulation. 109: 1834-41. PMID 15051636 DOI: 10.1161/01.Cir.0000125524.34234.13 |
0.385 |
|
| 2004 |
Decher N, Chen J, Sanguinetti MC. Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers. The Journal of Biological Chemistry. 279: 13859-65. PMID 14726518 DOI: 10.1074/Jbc.M313704200 |
0.592 |
|
| 2004 |
Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC. Physicochemical features of the HERG channel drug binding site. The Journal of Biological Chemistry. 279: 10120-7. PMID 14699101 DOI: 10.1074/Jbc.M310683200 |
0.585 |
|
| 2004 |
Decher N, Pirard B, Bundis F, Peukert S, Baringhaus KH, Busch AE, Steinmeyer K, Sanguinetti MC. Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels. The Journal of Biological Chemistry. 279: 394-400. PMID 14578345 DOI: 10.1074/Jbc.M307411200 |
0.634 |
|
| 2004 |
Seebohm G, Sanguinetti MC, Pusch M. Erratum: Tight coupling of rubidium conductance and inactivation in human KCNQ1 postassium channels (The Journal of Physiology (2003) vol. 552 (369-378)) The Journal of Physiology. 556. DOI: 10.1113/Jphysiol.2004.556001 |
0.55 |
|
| 2004 |
Sanguinetti MC, Tristani-Firouzi M. Gating of Cardiac Delayed Rectifier K+ Channels Cardiac Electrophysiology: Fourth Edition. 88-95. DOI: 10.1016/B0-7216-0323-8/50013-0 |
0.525 |
|
| 2003 |
Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, ... ... Sanguinetti M, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9 |
0.621 |
|
| 2003 |
Seebohm G, Pusch M, Chen J, Sanguinetti MC. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circulation Research. 93: 941-7. PMID 14576198 DOI: 10.1161/01.Res.0000102866.67863.2B |
0.625 |
|
| 2003 |
Seebohm G, Sanguinetti MC, Pusch M. Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels. The Journal of Physiology. 552: 369-78. PMID 14561821 DOI: 10.1111/J.1469-7793.2003.00369.X |
0.685 |
|
| 2003 |
Singh NA, Westenskow P, Charlier C, Pappas C, Leslie J, Dillon J, Anderson VE, Sanguinetti MC, Leppert MF. KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain : a Journal of Neurology. 126: 2726-37. PMID 14534157 DOI: 10.1093/Brain/Awg286 |
0.425 |
|
| 2003 |
Sanguinetti MC, Bennett PB. Antiarrhythmic drug target choices and screening. Circulation Research. 93: 491-9. PMID 14500332 DOI: 10.1161/01.Res.0000091829.63501.A8 |
0.383 |
|
| 2003 |
Piper DR, Varghese A, Sanguinetti MC, Tristani-Firouzi M. Gating currents associated with intramembrane charge displacement in HERG potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 10534-9. PMID 12928493 DOI: 10.1073/Pnas.1832721100 |
0.667 |
|
| 2003 |
Seebohm G, Chen J, Strutz N, Culberson C, Lerche C, Sanguinetti MC. Molecular determinants of KCNQ1 channel block by a benzodiazepine. Molecular Pharmacology. 64: 70-7. PMID 12815162 DOI: 10.1124/Mol.64.1.70 |
0.62 |
|
| 2003 |
Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC. Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Molecular Pharmacology. 63: 1051-8. PMID 12695533 DOI: 10.1124/Mol.63.5.1051 |
0.636 |
|
| 2003 |
Tristani-Firouzi M, Sanguinetti MC. Structural determinants and biophysical properties of HERG and KCNQ1 channel gating. Journal of Molecular and Cellular Cardiology. 35: 27-35. PMID 12623297 DOI: 10.1016/S0022-2828(02)00286-9 |
0.635 |
|
| 2002 |
Chen J, Seebohm G, Sanguinetti MC. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 99: 12461-6. PMID 12209010 DOI: 10.1073/Pnas.192367299 |
0.651 |
|
| 2002 |
Aizenman E, Sanguinetti MC. Channels gone bad. Reflections from a Tapas bar. Neuron. 34: 679-83. PMID 12062016 DOI: 10.1016/S0896-6273(02)00728-6 |
0.409 |
|
| 2002 |
Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC. Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block. The Journal of Biological Chemistry. 277: 23587-95. PMID 11960982 DOI: 10.1074/Jbc.M200448200 |
0.681 |
|
| 2002 |
Sanguinetti MC. Reduced transient outward K+ current and cardiac hypertrophy: causal relationship or epiphenomenon? Circulation Research. 90: 497-9. PMID 11909810 DOI: 10.1161/01.Res.0000014284.39141.8C |
0.638 |
|
| 2002 |
Tristani-Firouzi M, Chen J, Sanguinetti MC. Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels. The Journal of Biological Chemistry. 277: 18994-9000. PMID 11864984 DOI: 10.1074/Jbc.M200410200 |
0.628 |
|
| 2002 |
Chen J, Piper DR, Sanguinetti MC. Voltage sensing and activation gating of HCN pacemaker channels. Trends in Cardiovascular Medicine. 12: 42-5. PMID 11796244 DOI: 10.1016/S1050-1738(01)00141-4 |
0.666 |
|
| 2002 |
Sanguinetti MC. When the KChIPs are down. Nature Medicine. 8: 18-9. PMID 11786897 DOI: 10.1038/Nm0102-18 |
0.443 |
|
| 2002 |
Niwa R, Shimizu A, Honjo H, Sanguinetti M, Kamiya K. Molecular basis of voltage-dependent herg channel block by class III drugs Journal of Molecular and Cellular Cardiology. 34. DOI: 10.1016/S0022-2828(02)90317-2 |
0.54 |
|
| 2001 |
Chen J, Mitcheson JS, Tristani-Firouzi M, Lin M, Sanguinetti MC. The S4-S5 linker couples voltage sensing and activation of pacemaker channels Proceedings of the National Academy of Sciences of the United States of America. 98: 11277-11282. PMID 11553787 DOI: 10.1073/Pnas.201250598 |
0.679 |
|
| 2001 |
Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation. 104: 1071-5. PMID 11524404 DOI: 10.1161/Hc3501.093815 |
0.549 |
|
| 2001 |
Kamiya K, Mitcheson JS, Yasui K, Kodama I, Sanguinetti MC. Open channel block of HERG K+ channels by vesnarinone Molecular Pharmacology. 60: 244-253. PMID 11455010 DOI: 10.1124/Mol.60.2.244 |
0.595 |
|
| 2001 |
Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I. Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K+ current Circulation. 103: 1317-1324. PMID 11238279 DOI: 10.1161/01.Cir.103.9.1317 |
0.396 |
|
| 2001 |
Tristani-Firouzi M, Chen J, Mitcheson JS, Sanguinetti MC. Molecular biology of K+ channels and their role in cardiac arrhythmias American Journal of Medicine. 110: 50-59. PMID 11152866 DOI: 10.1016/S0002-9343(00)00623-9 |
0.685 |
|
| 2000 |
Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome Proceedings of the National Academy of Sciences of the United States of America. 97: 12329-12333. PMID 11005845 DOI: 10.1073/Pnas.210244497 |
0.607 |
|
| 2000 |
Chen J, Mitcheson JS, Lin M, Sanguinetti MC. Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel Journal of Biological Chemistry. 275: 36465-36471. PMID 10962006 DOI: 10.1074/Jbc.M007034200 |
0.651 |
|
| 2000 |
Sanchez-Chapula JA, Sanguinetti MC. Altered gating of HERG potassium channels by cobalt and lanthanum Pflugers Archiv European Journal of Physiology. 440: 264-274. PMID 10898527 DOI: 10.1007/S004240000263 |
0.638 |
|
| 2000 |
Sanguinetti MC. Long QT syndrome: Ionic basis and arrhythmia mechanism long QT syndrome type 1 Journal of Cardiovascular Electrophysiology. 11: 710-712. PMID 10868746 DOI: 10.1111/J.1540-8167.2000.Tb00035.X |
0.561 |
|
| 2000 |
Sanguinetti MC. Maximal function of minimal K+ channel subunits Trends in Pharmacological Sciences. 21: 199-201. PMID 10838601 DOI: 10.1016/S0165-6147(00)01475-9 |
0.611 |
|
| 2000 |
Mitcheson JS, Chen J, Sanguinetti MC. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate Journal of General Physiology. 115: 229-239. PMID 10694252 DOI: 10.1085/Jgp.115.3.229 |
0.655 |
|
| 2000 |
Zhang J, Bendahhou S, Sanguinetti MC, Ptácek LJ. Functional consequences of chloride channel gene (CLCN1) mutations causing myotonia congenita. Neurology. 54: 937-42. PMID 10690989 DOI: 10.1212/Wnl.54.4.937 |
0.507 |
|
| 2000 |
Zhang J, Sanguinetti MC, Kwiecinski H, Ptácek LJ. Mechanism of inverted activation of ClC-1 channels caused by a novel myotonia congenita mutation. The Journal of Biological Chemistry. 275: 2999-3005. PMID 10644771 DOI: 10.1074/Jbc.275.4.2999 |
0.604 |
|
| 2000 |
Sanguinetti MC, Mitcheson JS. Structural basis of HERG potassium channel function Pharmaceutical News. 7: 21-26. |
0.497 |
|
| 1999 |
Mitcheson JS, Sanguinetti MC. Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels Cellular Physiology and Biochemistry. 9: 201-216. PMID 10575198 DOI: 10.1159/000016317 |
0.661 |
|
| 1999 |
Sanguinetti MC. Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia Annals of the New York Academy of Sciences. 868: 406-413. PMID 10414310 DOI: 10.1111/J.1749-6632.1999.Tb11302.X |
0.603 |
|
| 1999 |
Franqueza L, Lin M, Shen J, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. The Journal of Biological Chemistry. 274: 21063-70. PMID 10409658 DOI: 10.1074/Jbc.274.30.21063 |
0.636 |
|
| 1999 |
Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating MT, Sanguinetti MC. Functional effects of mutations in KvLQT1 that cause long QT syndrome. Journal of Cardiovascular Electrophysiology. 10: 817-26. PMID 10376919 DOI: 10.1111/J.1540-8167.1999.Tb00262.X |
0.5 |
|
| 1999 |
Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. The Journal of Biological Chemistry. 274: 10113-8. PMID 10187793 DOI: 10.1074/Jbc.274.15.10113 |
0.643 |
|
| 1999 |
Sanguinetti MC, Xu QP. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes Journal of Physiology. 514: 667-675. PMID 9882738 DOI: 10.1111/J.1469-7793.1999.667Ad.X |
0.671 |
|
| 1999 |
Garrett SA, Mueller AL, Sanguinetti MC. Peptide toxins isolated from spider venom that modulate gating of voltage-dependent K+ channels Perspectives in Drug Discovery and Design. 15: 71-81. DOI: 10.1023/A:1017091402116 |
0.637 |
|
| 1999 |
Sanguinetti MC, Tristani-Firouzi M. Chapter 6 Delayed Rectifier Potassium Channels in Normal and Abnormal Cardiac Repolarization Current Topics in Membranes and Transport. 46: 85-101. DOI: 10.1016/S0070-2161(08)60922-3 |
0.553 |
|
| 1998 |
Su Z, Zou A, Nonaka A, Zubair I, Sanguinetti MC, Barry WH. Influence of prior Na+ pump activity on pump and Na+/Ca2+ exchange currents in mouse ventricular myocytes. The American Journal of Physiology. 275: H1808-17. PMID 9815089 DOI: 10.1152/Ajpheart.1998.275.5.H1808 |
0.334 |
|
| 1998 |
Salata JJ, Jurkiewicz NK, Wang J, Evans BE, Orme HT, Sanguinetti MC. A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Molecular Pharmacology. 54: 220-30. PMID 9658209 DOI: 10.1124/Mol.54.1.220 |
0.473 |
|
| 1998 |
Tristani-Firouzi M, Sanguinetti MC. Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits Journal of Physiology. 510: 37-45. PMID 9625865 DOI: 10.1111/J.1469-7793.1998.037Bz.X |
0.631 |
|
| 1998 |
Zou A, Xu QP, Sanguinetti MC. A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation Journal of Physiology. 509: 129-137. PMID 9547387 DOI: 10.1111/J.1469-7793.1998.129Bo.X |
0.656 |
|
| 1997 |
Sanguinetti MC, Zou A. Molecular physiology of cardiac delayed rectifier K+ channels Heart and Vessels. 12: 170-172. PMID 9476573 |
0.594 |
|
| 1997 |
Selnick HG, Liverton NJ, Baldwin JJ, Butcher JW, Claremon DA, Elliott JM, Freidinger RM, King SA, Libby BE, McIntyre CJ, Pribush DA, Remy DC, Smith GR, Tebben AJ, Jurkiewicz NK, ... ... Sanguinetti MC, et al. Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. Journal of Medicinal Chemistry. 40: 3865-8. PMID 9397166 DOI: 10.1021/Jm970517U |
0.331 |
|
| 1997 |
Splawski I, Tristani-Firouzi M, Lehmann MH, Sanguinetti MC, Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nature Genetics. 17: 338-40. PMID 9354802 DOI: 10.1038/Ng1197-338 |
0.574 |
|
| 1997 |
Sanguinetti MC, Spector PS. Potassium channelopathies Neuropharmacology. 36: 755-762. PMID 9225302 DOI: 10.1016/S0028-3908(97)00029-4 |
0.558 |
|
| 1997 |
Zou A, Curran ME, Keating MT, Sanguinetti MC. Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. The American Journal of Physiology. 272: H1309-14. PMID 9087606 DOI: 10.1152/Ajpheart.1997.272.3.H1309 |
0.671 |
|
| 1997 |
Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, Mueller AL. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Molecular Pharmacology. 51: 491-8. PMID 9058605 |
0.469 |
|
| 1997 |
Sanguinetti MC, Keating MT. Role of delayed rectifier potassium channels in cardiac repolarization and arrhythmias News in Physiological Sciences. 12: 152-157. DOI: 10.1152/Physiologyonline.1997.12.4.152 |
0.535 |
|
| 1996 |
Jurkiewicz NK, Wang J, Fermini B, Sanguinetti MC, Salata JJ. Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant: Block of the rapidly activating delayed rectified K+ current, I(Kr) Circulation. 94: 2938-2946. PMID 8941124 DOI: 10.1161/01.Cir.94.11.2938 |
0.408 |
|
| 1996 |
Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature. 384: 80-3. PMID 8900283 DOI: 10.1038/384080a0 |
0.563 |
|
| 1996 |
Keating MT, Sanguinetti MC. Pathophysiology of ion channel mutations. Current Opinion in Genetics & Development. 6: 326-33. PMID 8791523 DOI: 10.1016/S0959-437X(96)80010-4 |
0.538 |
|
| 1996 |
Sudo GZ, Sanguinetti MC. Intracellular [Mg++] determines specificity of K+ channel block by a class III antiarrhythmic drug Journal of Pharmacology and Experimental Therapeutics. 276: 951-957. PMID 8786575 |
0.444 |
|
| 1996 |
Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC. Fast inactivation causes rectification of the IKr channel. The Journal of General Physiology. 107: 611-9. PMID 8740374 DOI: 10.1085/Jgp.107.5.611 |
0.57 |
|
| 1996 |
Sanguinetti MC, Curran ME, Spector PS, Keating MT. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 93: 2208-12. PMID 8700910 DOI: 10.1073/Pnas.93.5.2208 |
0.508 |
|
| 1996 |
Keating MT, Sanguinetti MC. Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272: 681-5. PMID 8614827 DOI: 10.1126/Science.272.5262.681 |
0.309 |
|
| 1996 |
Spector PS, Curran ME, Keating MT, Sanguinetti MC. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circulation Research. 78: 499-503. PMID 8593709 DOI: 10.1161/01.Res.78.3.499 |
0.652 |
|
| 1995 |
Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81: 299-307. PMID 7736582 DOI: 10.1016/0092-8674(95)90340-2 |
0.591 |
|
| 1995 |
Peeters GA, Sanguinetti MC, Eki Y, Konarzewska H, Renlund DG, Karwande SV, Barry WH. Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies. The American Journal of Physiology. 268: H1757-64. PMID 7733380 DOI: 10.1152/Ajpheart.1995.268.4.H1757 |
0.313 |
|
| 1995 |
Konarzewska H, Peeters GA, Sanguinetti MC. Repolarizing K+ currents in nonfailing human hearts: Similarities between right septal subendocardial and left subepicardial ventricular myocytes Circulation. 92: 1179-1187. PMID 7648663 DOI: 10.1161/01.Cir.92.5.1179 |
0.434 |
|
| 1994 |
Hice RE, Folander K, Salata JJ, Smith JS, Sanguinetti MC, Swanson R. Species variants of the IsK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes PflüGers Archiv European Journal of Physiology. 426: 139-145. PMID 8146016 DOI: 10.1007/Bf00374681 |
0.442 |
|
| 1994 |
Hammerland LG, Parihar AS, Nemeth EF, Sanguinetti MC. Voltage-activated potassium currents of rabbit osteoclasts: effects of extracellular calcium. The American Journal of Physiology. 267: C1103-11. PMID 7524343 DOI: 10.1152/Ajpcell.1994.267.4.C1103 |
0.374 |
|
| 1994 |
Sanguinetti M. K+ Channels in Cardiovascular Medicine: From Basic Science to Clinical Practice Cardiovascular Research. 28: 930-930. DOI: 10.1093/Cvr/28.6.930 |
0.49 |
|
| 1994 |
Sanguinetti MC. Potassium Channels of Cardiac Myocytes Methods in Neurosciences. 19: 205-219. DOI: 10.1016/B978-0-12-185287-0.50017-X |
0.544 |
|
| 1993 |
Jurkiewicz NK, Sanguinetti MC. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent: Specific block of rapidly activating delayed rectifier K+ current by dofetilide Circulation Research. 72: 75-83. PMID 8417848 DOI: 10.1161/01.Res.72.1.75 |
0.367 |
|
| 1993 |
Swanson R, Hice RE, Folander K, Sanguinetti MC. The IsK protein, a slowly activating voltage-dependent K+ channel Seminars in Neuroscience. 5: 117-124. DOI: 10.1016/S1044-5765(05)80006-5 |
0.622 |
|
| 1993 |
Roden DM, Keating M, Sanguinetti MC. Potassium channels as targets for drug action P and T. 18. |
0.435 |
|
| 1992 |
Sanguinetti MC, Jurkiewicz NK. Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents PflüGers Archiv European Journal of Physiology. 420: 180-186. PMID 1620577 DOI: 10.1007/Bf00374988 |
0.474 |
|
| 1992 |
Sanguinetti MC. Modulation of potassium channels by antiarrhythmic and antihypertensive drugs Hypertension. 19: 228-236. PMID 1548049 DOI: 10.1161/01.Hyp.19.3.228 |
0.587 |
|
| 1992 |
Lynch JJ, Sanguinetti MC, Kimura S, Bassett AL. Therapeutic potential of modulating potassium currents in the diseased myocardium Faseb Journal. 6: 2952-2960. PMID 1386585 DOI: 10.1096/Fasebj.6.11.1386585 |
0.573 |
|
| 1991 |
Sanguinetti MC, Kurkiewicz NK, Scott A, Siegl PKS. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action Circulation Research. 68: 77-84. PMID 1984874 DOI: 10.1161/01.Res.68.1.77 |
0.368 |
|
| 1991 |
Sanguinetti MC, Jurkiewicz NK. Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells American Journal of Physiology - Heart and Circulatory Physiology. 260. PMID 1899980 DOI: 10.1152/Ajpheart.1991.260.2.H393 |
0.386 |
|
| 1990 |
Sanguinetti MC, Jurkiewicz NK. Lanthanum blocks a specific component of I(K) and screens membrane surface charge in cardiac cells American Journal of Physiology - Heart and Circulatory Physiology. 259. PMID 2260712 DOI: 10.1152/Ajpheart.1990.259.6.H1881 |
0.388 |
|
| 1990 |
Sanguinetti MC, Jurkiewicz NK. Two components of cardiac delayed rectifier K+ current: Differential sensitivity to block by class III antiarrhythmic agents Journal of General Physiology. 96: 195-215. PMID 2170562 DOI: 10.1085/Jgp.96.1.195 |
0.434 |
|
| 1990 |
Sanguinetti MC. Na+1-activated and ATP-sensitive K+ channels in the heart Progress in Clinical and Biological Research. 334: 85-109. PMID 2137936 |
0.464 |
|
| 1989 |
Wolleben CD, Sanguinetti MC, Siegl PKS. Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts Journal of Molecular and Cellular Cardiology. 21: 783-788. PMID 2506353 DOI: 10.1016/0022-2828(89)90717-7 |
0.478 |
|
| 1989 |
Kamp TJ, Sanguinetti MC, Miller RJ. Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791 Circulation Research. 64: 338-351. PMID 2463885 DOI: 10.1161/01.Res.64.2.338 |
0.568 |
|
| 1989 |
Martin CL, Borowicz LE, Schniepp HC, Sanguinetti MC. Voltage‐ and rate‐dependent reduction of Vmax of cardiac action potentials by SC‐40230 Drug Development Research. 17: 51-61. DOI: 10.1002/Ddr.430170106 |
0.312 |
|
| 1988 |
Kamp TJ, Sanguinetti MC, Miller RJ. Voltage-dependent binding of dihydropyridine calcium channel blockers to guinea pig ventricular myocytes Journal of Pharmacology and Experimental Therapeutics. 247: 1240-1247. PMID 2849670 |
0.34 |
|
| 1988 |
Sanguinetti MC, Scott AL, Zingaro GJ, Siegl PKS. BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle Proceedings of the National Academy of Sciences of the United States of America. 85: 8360-8364. PMID 2460868 DOI: 10.1073/Pnas.85.21.8360 |
0.562 |
|
| 1988 |
Borowicz LE, Martin CL, Sanguinetti MC. Cellular electrophysiological properties of a new aminosteroid antiarrhythmic agent, SC-35135 Journal of Cardiovascular Pharmacology. 12: 218-226. PMID 2459553 DOI: 10.1097/00005344-198808000-00012 |
0.301 |
|
| 1987 |
Sanguinetti MC. Na** plus -ACTIVATED K** plus CHANNEL OF VENTRICULAR MYOCYTES HAS MULTIPLE SUBCONDUCTANCE STATES Ieee/Engineering in Medicine and Biology Society Annual Conference. 137-138. |
0.565 |
|
| 1986 |
Sanguinetti MC, Krafte DS, Kass RS. Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644. The Journal of General Physiology. 88: 369-92. PMID 2428922 DOI: 10.1085/Jgp.88.3.369 |
0.562 |
|
| 1985 |
Kamp TJ, Miller RJ, Sanguinetti MC. Stimulation rate modulates effects of the dihydropyridine CGP 28 392 on cardiac calcium‐dependent action potentials British Journal of Pharmacology. 85: 523-528. PMID 3839707 DOI: 10.1111/J.1476-5381.1985.Tb08889.X |
0.382 |
|
| 1985 |
Kongsamut S, Kamp TJ, Miller RJ, Sanguinetti MC. Calcium channel agonist and antagonist effects of the stereoisomers of the dihydropyridine 202-791 Biochemical and Biophysical Research Communications. 130: 141-148. PMID 2411259 DOI: 10.1016/0006-291X(85)90393-6 |
0.478 |
|
| 1984 |
Sanguinetti MC, Kass RS. Photoalteration of calcium channel blockade in the cardiac Purkinje fiber. Biophysical Journal. 45: 873-80. PMID 6329345 DOI: 10.1016/S0006-3495(84)84233-2 |
0.543 |
|
| 1984 |
Sanguinetti MC, Kass RS. Regulation of cardiac calcium channel current and contractile activity by the dihydropyridine Bay K 8644 is voltage-dependent. Journal of Molecular and Cellular Cardiology. 16: 667-70. PMID 6206231 DOI: 10.1016/S0022-2828(84)80631-8 |
0.6 |
|
| 1984 |
Kass RS, Sanguinetti MC. Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms. The Journal of General Physiology. 84: 705-26. PMID 6096480 DOI: 10.1085/Jgp.84.5.705 |
0.436 |
|
| 1984 |
Sanguinetti MC, Kass RS. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circulation Research. 55: 336-48. PMID 6088117 DOI: 10.1161/01.Res.55.3.336 |
0.574 |
|
| 1983 |
Sanguinetti MC, West TC. Frequency-dependent depression of Vmax of slow response action potentials by a high concentration of papaverine. Journal of Cardiovascular Pharmacology. 5: 125-30. PMID 6186848 DOI: 10.1097/00005344-198301000-00020 |
0.318 |
|
| 1982 |
Sanguinetti MC, West TC. Comparison of papaverine and verapamil on frequency-dependent changes in Vmax of K-depolarized ventricular tissue. Journal of Cardiovascular Pharmacology. 4: 791-802. PMID 6182411 DOI: 10.1097/00005344-198209000-00015 |
0.312 |
|
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