| Year |
Citation |
Score |
| 2023 |
Li X, Bullert AJ, Han W, Yang W, Zhang QY, Ding X, Lehmler HJ. Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) in Wildtype, -Null, and CYP2A6-Humanized Mice. Chemical Research in Toxicology. 36: 1386-1397. PMID 37467352 DOI: 10.1021/acs.chemrestox.3c00128 |
0.337 |
|
| 2022 |
Lehmler HJ, Uwimana E, Dean LE, Kovalchuk N, Zhang QY, Ding X. Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models. Chemical Research in Toxicology. 35: 2310-2323. PMID 36473170 DOI: 10.1021/acs.chemrestox.2c00276 |
0.326 |
|
| 2022 |
Hannon SL, Ding X. Assessing cytochrome P450 function using genetically engineered mouse models. Advances in Pharmacology (San Diego, Calif.). 95: 253-284. PMID 35953157 DOI: 10.1016/bs.apha.2022.05.008 |
0.303 |
|
| 2022 |
Kelty JS, Kovalchuk N, Uwimana E, Yin L, Ding X, Van Winkle LS. In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 35853015 DOI: 10.1152/ajplung.00349.2021 |
0.334 |
|
| 2021 |
He Y, Ma J, Fan X, Ding L, Ding X, Zhang QY, Lin G. The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity. Acta Pharmaceutica Sinica. B. 11: 3820-3835. PMID 35024309 DOI: 10.1016/j.apsb.2021.07.013 |
0.324 |
|
| 2020 |
He Y, Lian W, Ding L, Fan X, Ma J, Zhang QY, Ding X, Lin G. Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites. Archives of Toxicology. PMID 33033841 DOI: 10.1007/s00204-020-02921-0 |
0.363 |
|
| 2020 |
Kovalchuk N, Zhang QY, Van Winkle L, Ding X. Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32974682 DOI: 10.1093/Toxsci/Kfaa114 |
0.408 |
|
| 2020 |
Leonardi A, Kovalchuk N, Yin L, Endres L, Evke S, Nevins S, Martin S, Dedon PC, Melendez JA, Van Winkle L, Zhang QY, Ding X, Begley TJ. The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene. Epigenetics. 1-18. PMID 32303148 DOI: 10.1080/15592294.2020.1750213 |
0.423 |
|
| 2020 |
Fan X, Ding X, Zhang QY. Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model. Acta Pharmaceutica Sinica. B. 10: 123-135. PMID 31993311 DOI: 10.1016/J.Apsb.2019.12.002 |
0.464 |
|
| 2020 |
Han W, kovalchuk N, Ding L, Liu P, Yang W, Zhang Q, Winkle LV, Ding X. Role of myeloid cell CYP19A1 in lung airway tissue repair following naphthalene induced epithelial injury in a mouse model The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04147 |
0.336 |
|
| 2019 |
Ding L, Li L, Liu S, Bao X, Dickman KG, Sell SS, Mei C, Zhang QY, Gu J, Ding X. Proximal Tubular Vacuolization and Hypersensitivity to Drug-induced Nephrotoxicity in Male Mice with Decreased Expression of the NADPH-Cytochrome P450 Reductase. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31693140 DOI: 10.1093/Toxsci/Kfz225 |
0.404 |
|
| 2019 |
Kovalchuk N, Zhang QY, Kelty J, Van Winkle LS, Ding X. Toxicokinetic interaction between hepatic disposition and pulmonary bioactivation of inhaled naphthalene studied using Cyp2abfgs-null and CYP2A13/2F1-humanized mice with deficient hepatic cytochrome P450 activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31594800 DOI: 10.1124/Dmd.119.088930 |
0.478 |
|
| 2019 |
Hartog M, Zhang QY, Ding X. Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31388674 DOI: 10.1093/Toxsci/Kfz171 |
0.322 |
|
| 2019 |
Fan X, Li H, Ding X, Zhang QY. Contributions of Hepatic and Intestinal Metabolism to the Disposition of Niclosamide, A Repurposed Drug with Poor Bioavailability. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31040114 DOI: 10.1124/Dmd.119.086678 |
0.451 |
|
| 2019 |
Carratt SA, Kovalchuk N, Ding X, Van Winkle LS. Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of Postnatal Age and Sex. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31020322 DOI: 10.1093/Toxsci/Kfz100 |
0.388 |
|
| 2019 |
Carratt SA, Hartog M, Buchholz BA, Kuhn EA, Collette NM, Ding X, Van Winkle LS. Naphthalene Genotoxicity: DNA Adducts in Primate and Mouse Airway Explants. Toxicology Letters. PMID 30684585 DOI: 10.1016/J.Toxlet.2019.01.009 |
0.366 |
|
| 2019 |
Buchholz BA, Carratt SA, Kuhn EA, Collette NM, Ding X, Van Winkle LS. Naphthalene DNA Adduct Formation and Tolerance in the Lung. Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions With Materials and Atoms. 438: 119-123. PMID 30631217 DOI: 10.1016/J.Nimb.2018.07.004 |
0.354 |
|
| 2018 |
Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz F, Zhang QY, Ding X. CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30093418 DOI: 10.1124/Dmd.118.083303 |
0.353 |
|
| 2018 |
Li L, Zhang QY, Ding X. A CYP2B6-humanized mouse model and its potential applications. Drug Metabolism and Pharmacokinetics. PMID 29402634 DOI: 10.1016/J.Dmpk.2018.01.001 |
0.449 |
|
| 2018 |
Hartog M, Ding X. Role of P450 enzymes in cigarette smoke induced lung inflammation Drug Metabolism and Pharmacokinetics. 33: S35. DOI: 10.1016/J.Dmpk.2017.11.129 |
0.328 |
|
| 2017 |
Li L, Carratt S, Hartog M, Kovalchik N, Jia K, Wang Y, Zhang QY, Edwards P, Winkle LV, Ding X. Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice. Environmental Health Perspectives. 125: 067004. PMID 28599267 DOI: 10.1289/Ehp844 |
0.364 |
|
| 2017 |
Li L, Bao X, Zhang QY, Negishi M, Ding X. Role of CYP2B in Phenobarbital-induced Hepatocyte Proliferation in Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28546505 DOI: 10.1124/Dmd.117.076406 |
0.403 |
|
| 2017 |
Kovalchuk N, Kelty J, Li L, Hartog M, Zhang QY, Edwards P, Van Winkle L, Ding X. Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene. Toxicology and Applied Pharmacology. PMID 28527914 DOI: 10.1016/J.Taap.2017.05.015 |
0.404 |
|
| 2017 |
Fasullo M, Freedland J, St John N, Cera C, Egner P, Hartog M, Ding X. An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae. Environmental and Molecular Mutagenesis. PMID 28436563 DOI: 10.1002/Em.22093 |
0.452 |
|
| 2016 |
Xie F, Ding X, Zhang QY. An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharmaceutica Sinica. B. 6: 374-383. PMID 27709006 DOI: 10.1016/J.Apsb.2016.07.012 |
0.394 |
|
| 2016 |
Sheng J, Wang Y, Turesky RJ, Kluetzman K, Zhang QY, Ding XX. A Novel Transgenic Mouse Model for Studying Human Serum Albumin as A Biomarker of Carcinogenic Exposure. Chemical Research in Toxicology. PMID 27028147 DOI: 10.1021/Acs.Chemrestox.5B00529 |
0.384 |
|
| 2016 |
Su T, Li J, Meng M, Zhao S, Xu Y, Ding X, Jiang H, Ma X, Qian J, Han W, Sun L, Li X, Liu Z, Pan L, Xue X. Bone marrow stromal cells induced activation of nuclear factor κB signaling protects non-Hodgkin's B lymphoma cells from apoptosis. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 26873486 DOI: 10.1007/s13277-016-4860-1 |
0.361 |
|
| 2015 |
Turesky RJ, Konorev D, Fan X, Tang Y, Yao L, Ding X, Xie F, Zhu Y, Zhang QY. The Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-Pyrido[2,3-b]Indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice. Chemical Research in Toxicology. PMID 26583703 DOI: 10.1021/Acs.Chemrestox.5B00405 |
0.459 |
|
| 2015 |
Hough LB, Nalwalk JW, Ding X, Sheer N. Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26109562 DOI: 10.1124/Dmd.115.065490 |
0.377 |
|
| 2015 |
Hough LB, Nalwalk JW, Yang W, Ding X. Neuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms. Brain Research. 1616: 10-8. PMID 25935691 DOI: 10.1016/J.Brainres.2015.04.045 |
0.333 |
|
| 2015 |
Zhu Y, Xie F, Ding L, Fan X, Ding X, Zhang QY. Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis. The Journal of Pharmacology and Experimental Therapeutics. 354: 10-7. PMID 25926522 DOI: 10.1124/Jpet.115.223263 |
0.427 |
|
| 2015 |
Liu Z, Megaraj V, Li L, Sell S, Hu J, Ding X. Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 698-702. PMID 25710941 DOI: 10.1124/Dmd.115.063305 |
0.404 |
|
| 2015 |
Spink BC, Bloom MS, Wu S, Sell S, Schneider E, Ding X, Spink DC. Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer. Toxicology and Applied Pharmacology. 282: 30-41. PMID 25447411 DOI: 10.1016/J.Taap.2014.10.017 |
0.34 |
|
| 2015 |
Liu Z, Li L, Wu H, Hu J, Ma J, Zhang QY, Ding X. Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 208-16. PMID 25409894 DOI: 10.1124/Dmd.114.061812 |
0.472 |
|
| 2014 |
Xu S, Ren Z, Wang Y, Ding X, Jiang Y. Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells. Acta Pharmaceutica Sinica. B. 4: 464-469. PMID 26579418 DOI: 10.1016/J.Apsb.2014.10.003 |
0.333 |
|
| 2014 |
Li L, Megaraj V, Wei Y, Ding X. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse. Carcinogenesis. 35: 2584-91. PMID 25173884 DOI: 10.1093/Carcin/Bgu182 |
0.471 |
|
| 2014 |
Hough LB, Nalwalk JW, Yang W, Ding X. Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia. Brain Research. 1578: 30-7. PMID 25020125 DOI: 10.1016/J.Brainres.2014.07.007 |
0.302 |
|
| 2014 |
Ahlawat S, Xie F, Zhu Y, D'Hondt R, Ding X, Zhang QY, Mantis NJ. Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage. Scientific Reports. 4: 5551. PMID 24989705 DOI: 10.1038/Srep05551 |
0.448 |
|
| 2014 |
Jia K, Li L, Liu Z, Hartog M, Kluetzman K, Zhang QY, Ding X. Generation and characterization of a novel CYP2A13--transgenic mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1341-8. PMID 24907355 DOI: 10.1124/Dmd.114.059188 |
0.451 |
|
| 2014 |
Chen X, Cao Y, Zhang H, Zhu Z, Liu M, Liu H, Ding X, Hong Z, Li W, Lv D, Wang L, Zhuo X, Zhang J, Xie XQ, Chai Y. Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli. Analytical Chemistry. 86: 4748-57. PMID 24731167 DOI: 10.1021/ac500287e |
0.491 |
|
| 2014 |
Megaraj V, Ding X, Fang C, Kovalchuk N, Zhu Y, Zhang QY. Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice. Chemical Research in Toxicology. 27: 656-62. PMID 24552495 DOI: 10.1021/Tx4004769 |
0.462 |
|
| 2014 |
Shen S, Li L, Ding X, Zheng J. Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes. Chemical Research in Toxicology. 27: 27-33. PMID 24320693 DOI: 10.1021/Tx400305W |
0.448 |
|
| 2014 |
Zhu Y, Ding X, Fang C, Zhang QY. Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure. Molecular Pharmacology. 85: 139-47. PMID 24184963 DOI: 10.1124/Mol.113.088914 |
0.494 |
|
| 2014 |
Hu J, Sheng L, Li L, Zhou X, Xie F, D'Agostino J, Li Y, Ding X. Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 23-7. PMID 24104196 DOI: 10.1124/Dmd.113.054429 |
0.472 |
|
| 2014 |
Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. Carcinogenesis. 35: 131-7. PMID 23917075 DOI: 10.1093/Carcin/Bgt269 |
0.457 |
|
| 2014 |
Xu S, Ding X, Jiang Y, Wang Y, Ren Z. Expression of cytochrome P450 genes in human cord blood hematopoietic stem and progenitor cells (1139.7) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1139.7 |
0.396 |
|
| 2013 |
Li L, Jia K, Zhou X, McCallum SE, Hough LB, Ding X. Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse. The Journal of Pharmacology and Experimental Therapeutics. 347: 746-54. PMID 24045421 DOI: 10.1124/Jpet.113.208256 |
0.347 |
|
| 2013 |
Zhang Y, Dong F, Zhang N, Cheng H, Pang Y, Wang X, Xu J, Ding X, Cheng T, Gu J, Yuan W. Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice. Plos One. 8: e69913. PMID 23922855 DOI: 10.1371/Journal.Pone.0069913 |
0.377 |
|
| 2013 |
Xie F, Fang C, Schnittke N, Schwob JE, Ding X. Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6. Toxicology and Applied Pharmacology. 272: 598-607. PMID 23921153 DOI: 10.1016/J.Taap.2013.07.020 |
0.319 |
|
| 2013 |
Wu H, Liu Z, Ling G, Lawrence D, Ding X. Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 476-85. PMID 23884085 DOI: 10.1093/Toxsci/Kft165 |
0.627 |
|
| 2013 |
Lee C, Ding X, Riddick DS. Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1782-6. PMID 23846873 DOI: 10.1124/Dmd.113.052993 |
0.497 |
|
| 2013 |
Liu S, Yao Y, Lu S, Aldous K, Ding X, Mei C, Gu J. The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models. Toxicology and Applied Pharmacology. 272: 230-7. PMID 23732084 DOI: 10.1016/J.Taap.2013.05.022 |
0.439 |
|
| 2013 |
Yao Y, Liu S, Wang Y, Yuan W, Ding X, Cheng T, Shen Q, Gu J. Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice. Neuroscience Letters. 548: 84-9. PMID 23727388 DOI: 10.1016/J.Neulet.2013.05.043 |
0.431 |
|
| 2013 |
Xie F, D'Agostino J, Zhou X, Ding X. Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity. Chemical Research in Toxicology. 26: 388-98. PMID 23360412 DOI: 10.1021/Tx300479W |
0.427 |
|
| 2013 |
Lee C, Ding X, Riddick DS. The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 457-65. PMID 23169610 DOI: 10.1124/Dmd.112.048835 |
0.447 |
|
| 2013 |
Zhang P, Jia K, Fang C, Zhou X, Ding X, Zhang QY. Dietary regulation of mouse intestinal P450 expression and drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 529-35. PMID 23160819 DOI: 10.1124/Dmd.112.049403 |
0.471 |
|
| 2013 |
Riddick DS, Ding X, Wolf CR, Porter TD, Pandey AV, Zhang QY, Gu J, Finn RD, Ronseaux S, McLaughlin LA, Henderson CJ, Zou L, Flück CE. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 12-23. PMID 23086197 DOI: 10.1124/Dmd.112.048991 |
0.451 |
|
| 2013 |
Wei Y, Li L, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X. Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 132-40. PMID 23073733 DOI: 10.1124/Dmd.112.048736 |
0.51 |
|
| 2012 |
Fang C, Bolivar VJ, Gu J, Yang W, Zeitlin SO, Ding X. Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model Neuroscience. 218: 170-180. PMID 22626646 DOI: 10.1016/J.Neuroscience.2012.05.027 |
0.354 |
|
| 2012 |
Lin Y, Yao Y, Liu S, Wang L, Moorthy B, Xiong D, Cheng T, Ding X, Gu J. Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice Toxicology Letters. 212: 97-105. PMID 22595614 DOI: 10.1016/J.Toxlet.2012.05.005 |
0.483 |
|
| 2012 |
D'Agostino J, Ding X, Zhang P, Jia K, Fang C, Zhu Y, Spink DC, Zhang QY. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. The Journal of Biological Chemistry. 287: 17777-88. PMID 22453923 DOI: 10.1074/Jbc.M112.354274 |
0.45 |
|
| 2012 |
Wei Y, Wu H, Li L, Liu Z, Zhou X, Zhang QY, Weng Y, D'Agostino J, Ling G, Zhang X, Kluetzman K, Yao Y, Ding X. Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1144-50. PMID 22397853 DOI: 10.1124/Dmd.112.044826 |
0.75 |
|
| 2012 |
Zhou X, D'Agostino J, Xie F, Ding X. Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 233-41. PMID 22262919 DOI: 10.1124/Jpet.111.190173 |
0.452 |
|
| 2012 |
Zhou X, D'Agostino J, Li L, Moore CD, Yost GS, Ding X. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 642-7. PMID 22228748 DOI: 10.1124/Dmd.111.044081 |
0.413 |
|
| 2012 |
Megaraj V, Zhou X, Liu Z, Xie F, D'Agostino J, Yang W, Ding X. Abstract 5465: Role of CYP2A13 in NNK bioactivation and lung tumorigenesis:In vivostudies using a CYP2A13-humanized mouse model Cancer Research. 72: 5465-5465. DOI: 10.1158/1538-7445.Am2012-5465 |
0.46 |
|
| 2011 |
Li L, Wei Y, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. The Journal of Pharmacology and Experimental Therapeutics. 339: 62-71. PMID 21730012 DOI: 10.1124/Jpet.111.184671 |
0.486 |
|
| 2011 |
Hollander MC, Zhou X, Maier CR, Patterson AD, Ding X, Dennis PA. A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. Carcinogenesis. 32: 1279-84. PMID 21625009 DOI: 10.1093/Carcin/Bgr097 |
0.389 |
|
| 2011 |
Zhang X, Li L, Ding X, Kaminsky LS. Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1433-9. PMID 21562147 DOI: 10.1124/Dmd.111.038836 |
0.318 |
|
| 2011 |
Xie F, Zhou X, Genter MB, Behr M, Gu J, Ding X. The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5 Drug Metabolism and Disposition. 39: 947-951. PMID 21415250 DOI: 10.1124/Dmd.110.037895 |
0.514 |
|
| 2011 |
Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, ... Ding X, et al. Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain. 152: 878-87. PMID 21316152 DOI: 10.1016/J.Pain.2011.01.001 |
0.381 |
|
| 2011 |
Zhou X, Wei Y, Xie F, Laukaitis CM, Karn RC, Kluetzman K, Gu J, Zhang QY, Roberts DW, Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Molecular Pharmacology. 79: 710-23. PMID 21252290 DOI: 10.1124/Mol.110.070045 |
0.449 |
|
| 2011 |
Gonzalez M, Sealls W, Jesch ED, Brosnan MJ, Ladunga I, Ding X, Black PN, DiRusso CC. Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease. Physiological Genomics. 43: 121-35. PMID 21098682 DOI: 10.1152/Physiolgenomics.00209.2010 |
0.401 |
|
| 2011 |
Ding X, Zhou X. Abstract 3236: Role of mouse and human CYP2A enzymes in the bioactivation of the tobacco-specific lung procarcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Cancer Research. 71: 3236-3236. DOI: 10.1158/1538-7445.Am2011-3236 |
0.469 |
|
| 2010 |
Xie F, Zhou X, Behr M, Fang C, Horii Y, Gu J, Kannan K, Ding X. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation Toxicology and Applied Pharmacology. 249: 101-106. PMID 20840855 DOI: 10.1016/J.Taap.2010.09.003 |
0.517 |
|
| 2010 |
Weems JM, Lamb JG, D'Agostino J, Ding X, Yost GS. Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. Chemical Research in Toxicology. 23: 1682-90. PMID 20795680 DOI: 10.1021/Tx100147Z |
0.43 |
|
| 2010 |
Wei Y, Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. The Journal of Pharmacology and Experimental Therapeutics. 334: 69-77. PMID 20375200 DOI: 10.1124/Jpet.110.167411 |
0.47 |
|
| 2010 |
Weng Y, Xie F, Xu L, Zagorevski D, Spink DC, Ding X. Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry. Analytical Biochemistry. 402: 121-8. PMID 20361922 DOI: 10.1016/J.Ab.2010.03.034 |
0.557 |
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| 2010 |
Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, ... ... Ding X, et al. Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nature Neuroscience. 13: 284-6. PMID 20139973 DOI: 10.1038/Nn.2497 |
0.329 |
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| 2010 |
Zhou X, Zhuo X, Xie F, Kluetzman K, Shu YZ, Humphreys WG, Ding X. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. The Journal of Pharmacology and Experimental Therapeutics. 332: 578-87. PMID 19923441 DOI: 10.1124/Jpet.109.162610 |
0.679 |
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| 2009 |
Wu H, Zhang X, Ling G, D'Agostino J, Ding X. Mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple cis-regulatory single nucleotide polymorphisms. Pharmacogenetics and Genomics. 19: 852-63. PMID 20431511 DOI: 10.1097/Fpc.0B013E3283313Aa5 |
0.626 |
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| 2009 |
D'Agostino J, Zhuo X, Shadid M, Morgan DG, Zhang X, Humphreys WG, Shu YZ, Yost GS, Ding X. The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract Drug Metabolism and Disposition. 37: 2018-2027. PMID 19608696 DOI: 10.1124/Dmd.109.027300 |
0.611 |
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| 2009 |
Sim SC, Miller WL, Zhong XB, Arlt W, Ogata T, Ding X, Wolf CR, Flück CE, Pandey AV, Henderson CJ, Porter TD, Daly AK, Nebert DW, Ingelman-Sundberg M. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene. Pharmacogenetics and Genomics. 19: 565-6. PMID 19535965 DOI: 10.1097/Fpc.0B013E32832Af5B7 |
0.356 |
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| 2009 |
Zhou X, Zhang X, Weng Y, Fang C, Kaminsky L, Ding X. High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice. The Journal of Steroid Biochemistry and Molecular Biology. 117: 81-6. PMID 19524040 DOI: 10.1016/J.Jsbmb.2009.06.002 |
0.584 |
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| 2009 |
Zhang QY, Fang C, Zhang J, Dunbar D, Kaminsky L, Ding X. An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 651-7. PMID 19056912 DOI: 10.1124/Dmd.108.025429 |
0.495 |
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| 2008 |
D'Agostino J, Zhang X, Wu H, Ling G, Wang S, Zhang QY, Liu F, Ding X. Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2316-23. PMID 18669584 DOI: 10.1124/Dmd.108.022822 |
0.658 |
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| 2008 |
Fang C, Gu J, Xie F, Behr M, Yang W, Abel ED, Ding X. Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1722-8. PMID 18463197 DOI: 10.1124/Dmd.108.021881 |
0.443 |
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| 2008 |
Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. The Journal of Biological Chemistry. 283: 17147-57. PMID 18442974 DOI: 10.1074/Jbc.M802447200 |
0.37 |
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| 2008 |
Fang C, Behr M, Xie F, Lu S, Doret M, Luo H, Yang W, Aldous K, Ding X, Gu J. Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism. Toxicology and Applied Pharmacology. 227: 48-55. PMID 18031782 DOI: 10.1016/J.Taap.2007.10.014 |
0.413 |
|
| 2007 |
Weng Y, Fang C, Turesky RJ, Behr M, Kaminsky LS, Ding X. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Research. 67: 7825-32. PMID 17699788 DOI: 10.1158/0008-5472.Can-07-1006 |
0.627 |
|
| 2007 |
Zhang X, D'Agostino J, Wu H, Zhang QY, von Weymarn L, Murphy SE, Ding X. CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. The Journal of Pharmacology and Experimental Therapeutics. 323: 570-8. PMID 17671098 DOI: 10.1124/Jpet.107.127068 |
0.456 |
|
| 2007 |
Zhang QY, Kaminsky LS, Dunbar D, Zhang J, Ding X. Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1617-23. PMID 17567730 DOI: 10.1124/Dmd.107.016543 |
0.472 |
|
| 2007 |
Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. The Journal of Pharmacology and Experimental Therapeutics. 321: 9-17. PMID 17218484 DOI: 10.1124/Jpet.106.118240 |
0.476 |
|
| 2007 |
Ling G, Wei Y, Ding X. Transcriptional regulation of human CYP2A13 expression in the respiratory tract by CCAAT/enhancer binding protein and epigenetic modulation. Molecular Pharmacology. 71: 807-16. PMID 17148654 DOI: 10.1124/Mol.106.031104 |
0.656 |
|
| 2007 |
Zhou X, Gu J, Ding X. An exploration of the mechanisms for increased resistance of lateral nasal gland to acetaminophen toxicity in Cyp2g1‐null mice The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A416-C |
0.324 |
|
| 2007 |
D'Agostino J, Zhang X, Wu H, Ling G, Zhang Q, Ding X. Characterization of CYP2A13*2, a variant cytochrome P450 allele associated with decreased incidences of lung adenocarcinoma in smokers The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a415-b |
0.559 |
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| 2005 |
Zhang QY, Gu J, Su T, Cui H, Zhang X, D'Agostino J, Zhuo X, Yang W, Swiatek PJ, Ding X. Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochemical and Biophysical Research Communications. 338: 318-24. PMID 16126166 DOI: 10.1016/J.Bbrc.2005.08.086 |
0.742 |
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| 2005 |
Zhang X, Zhang QY, Liu D, Su T, Weng Y, Ling G, Chen Y, Gu J, Schilling B, Ding X. Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1423-8. PMID 16014766 DOI: 10.1124/Dmd.105.005769 |
0.763 |
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| 2005 |
Weng Y, DiRusso CC, Reilly AA, Black PN, Ding X. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. The Journal of Biological Chemistry. 280: 31686-98. PMID 16006652 DOI: 10.1074/Jbc.M504447200 |
0.648 |
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| 2005 |
Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes. Chemical Research in Toxicology. 18: 913-8. PMID 15962925 DOI: 10.1021/Tx0500777 |
0.349 |
|
| 2005 |
von Weymarn LB, Zhang QY, Ding X, Hollenberg PF. Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis. 26: 621-9. PMID 15579482 DOI: 10.1093/Carcin/Bgh348 |
0.368 |
|
| 2005 |
Gu J, Cui H, Behr M, Zhang L, Zhang QY, Yang W, Hinson JA, Ding X. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Molecular Pharmacology. 67: 623-30. PMID 15550675 DOI: 10.1124/Mol.104.007898 |
0.502 |
|
| 2005 |
Bao Z, He XY, Ding X, Prabhu S, Hong JY. Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 258-61. PMID 15528319 DOI: 10.1124/Dmd.104.002105 |
0.344 |
|
| 2005 |
Wu L, Gu J, Cui H, Zhang QY, Behr M, Fang C, Weng Y, Kluetzman K, Swiatek PJ, Yang W, Kaminsky L, Ding X. Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450. The Journal of Pharmacology and Experimental Therapeutics. 312: 35-43. PMID 15328377 DOI: 10.1124/Jpet.104.073353 |
0.681 |
|
| 2004 |
Su T, Ding X. Regulation of the cytochrome P450 2A genes. Toxicology and Applied Pharmacology. 199: 285-94. PMID 15364544 DOI: 10.1016/J.Taap.2003.11.029 |
0.602 |
|
| 2004 |
He XY, Shen J, Ding X, Lu AY, Hong JY. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1516-21. PMID 15333516 DOI: 10.1124/Dmd.104.001370 |
0.369 |
|
| 2004 |
He XY, Shen J, Hu WY, Ding X, Lu AY, Hong JY. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. Archives of Biochemistry and Biophysics. 427: 143-53. PMID 15196988 DOI: 10.1016/J.Abb.2004.03.016 |
0.361 |
|
| 2004 |
Zhang X, Caggana M, Cutler TL, Ding X. Development of a real-time polymerase chain reaction-based method for the measurement of relative allelic expression and identification of CYP2A13 alleles with decreased expression in human lung. The Journal of Pharmacology and Experimental Therapeutics. 311: 373-81. PMID 15175424 DOI: 10.1124/Jpet.104.069872 |
0.389 |
|
| 2004 |
Ling G, Gu J, Genter MB, Zhuo X, Ding X. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-Biological Interactions. 147: 247-58. PMID 15135081 DOI: 10.1016/J.Cbi.2004.02.003 |
0.731 |
|
| 2004 |
Ling G, Hauer CR, Gronostajski RM, Pentecost BT, Ding X. Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo. The Journal of Biological Chemistry. 279: 27888-95. PMID 15123731 DOI: 10.1074/Jbc.M403705200 |
0.616 |
|
| 2004 |
Zhuo X, Gu J, Behr MJ, Swiatek PJ, Cui H, Zhang QY, Xie Y, Collins DN, Ding X. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression. The Journal of Pharmacology and Experimental Therapeutics. 308: 719-28. PMID 14610229 DOI: 10.1124/Jpet.103.060301 |
0.7 |
|
| 2003 |
Chen Y, Liu YQ, Su T, Ren X, Shi L, Liu D, Gu J, Zhang QY, Ding X. Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Biochemical Pharmacology. 66: 1245-51. PMID 14505803 DOI: 10.1016/S0006-2952(03)00476-3 |
0.564 |
|
| 2003 |
Jalas JR, Ding X, Murphy SE. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1199-202. PMID 12975327 DOI: 10.1124/Dmd.31.10.1199 |
0.361 |
|
| 2003 |
Wu L, Gu J, Weng Y, Kluetzman K, Swiatek P, Behr M, Zhang QY, Zhuo X, Xie Q, Ding X. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis (New York, N.Y. : 2000). 36: 177-81. PMID 12929087 DOI: 10.1002/Gene.10214 |
0.75 |
|
| 2003 |
Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, Ding X. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. The Journal of Biological Chemistry. 278: 25895-901. PMID 12697746 DOI: 10.1074/Jbc.M303125200 |
0.654 |
|
| 2003 |
Ding X, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Review of Pharmacology and Toxicology. 43: 149-73. PMID 12171978 DOI: 10.1146/Annurev.Pharmtox.43.100901.140251 |
0.463 |
|
| 2002 |
Zhang X, Su T, Zhang QY, Gu J, Caggana M, Li H, Ding X. Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. The Journal of Pharmacology and Experimental Therapeutics. 302: 416-23. PMID 12130698 DOI: 10.1124/Jpet.302.2.416 |
0.521 |
|
| 2002 |
Su T, Zhang QY, Zhang J, Swiatek P, Ding X. Expression of the rat CYP2A3 gene in transgenic mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 548-52. PMID 11950786 DOI: 10.1124/Dmd.30.5.548 |
0.617 |
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| 2001 |
Xie Y, Madelian V, Zhang J, Ling G, Ding X. Activation of the NPTA element of the CYP2A3 gene by NFI-A2, a nasal mucosa-selective nuclear factor 1 isoform. Biochemical and Biophysical Research Communications. 289: 1225-8. PMID 11741324 DOI: 10.1006/bbrc.2001.6084 |
0.554 |
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| 2001 |
Zhuo X, Schwob JE, Swiatek PJ, Ding X. Mouse cyp2g1 gene: promoter structure and tissue-specific expression of a cyp2g1-lacz fusion gene in transgenic mice. Archives of Biochemistry and Biophysics. 391: 127-36. PMID 11414693 DOI: 10.1006/Abbi.2001.2410 |
0.603 |
|
| 2000 |
Spink DC, Spink BC, Zhuo X, Hussain MM, Gierthy JF, Ding X. NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. The Journal of Steroid Biochemistry and Molecular Biology. 74: 11-8. PMID 11074351 DOI: 10.1016/S0960-0760(00)00083-2 |
0.607 |
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| 2000 |
Xie Q, Zhang QY, Zhang Y, Su T, Gu J, Kaminsky LS, Ding X. Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1311-6. PMID 11038158 |
0.535 |
|
| 2000 |
Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Research. 60: 5074-9. PMID 11016631 |
0.579 |
|
| 2000 |
Gu J, Su T, Chen Y, Zhang QY, Ding X. Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Toxicology and Applied Pharmacology. 165: 158-62. PMID 10828211 DOI: 10.1006/Taap.2000.8923 |
0.616 |
|
| 2000 |
Meng Q, Su T, Olivero OA, Poirier MC, Shi X, Ding X, Walker VE. Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 54: 322-9. PMID 10774814 DOI: 10.1093/Toxsci/54.2.322 |
0.486 |
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| 2000 |
Zhang J, Zhang QY, Guo J, Zhou Y, Ding X. Identification and functional characterization of a conserved, nuclear factor 1-like element in the proximal promoter region of CYP1A2 gene specifically expressed in the liver and olfactory mucosa. Journal of Biological Chemistry. 275: 8895-8902. PMID 10722736 DOI: 10.1074/Jbc.275.12.8895 |
0.377 |
|
| 1999 |
Von Weymarn LB, Felicia ND, Ding X, Murphy SE. N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: Catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes Chemical Research in Toxicology. 12: 1254-1261. PMID 10604876 DOI: 10.1021/Tx990128Y |
0.35 |
|
| 1999 |
Gu J, Dudley C, Su T, Spink DC, Zhang QY, Moss RL, Ding X. Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa. Biochemical and Biophysical Research Communications. 266: 262-7. PMID 10581200 DOI: 10.1006/Bbrc.1999.1807 |
0.578 |
|
| 1999 |
Zhuo X, Gu J, Zhang QY, Spink DC, Kaminsky LS, Ding X. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 288: 463-71. PMID 9918546 |
0.63 |
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| 1998 |
Zhang J, Ding X. Identification and Characterization of a Novel Tissue-specific Transcriptional Activating Element in the 5′-Flanking Region of theCYP2A3 Gene Predominantly Expressed in Rat Olfactory Mucosa Journal of Biological Chemistry. 273: 23454-23462. PMID 9722582 DOI: 10.1074/Jbc.273.36.23454 |
0.419 |
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| 1998 |
Genter MB, Liang HC, Gu J, Ding X, Negishi M, McKinnon RA, Nebert DW. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse Biochemical Pharmacology. 55: 1819-1826. PMID 9714300 DOI: 10.1016/S0006-2952(98)00004-5 |
0.438 |
|
| 1998 |
Su T, He W, Gu J, Lipinskas TW, Ding X. Differential xenobiotic induction of CYP2A5 in mouse liver, kidney, lung, and olfactory mucosa. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 26: 822-4. PMID 9698299 |
0.548 |
|
| 1998 |
Zhang QY, Raner G, Ding X, Dunbar D, Coon MJ, Kaminsky LS. Characterization of the cytochrome P450 CYP2J4: expression in rat small intestine and role in retinoic acid biotransformation from retinal. Archives of Biochemistry and Biophysics. 353: 257-64. PMID 9606960 DOI: 10.1006/Abbi.1998.0654 |
0.385 |
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| 1997 |
Gu J, Walker VE, Lipinskas TW, Walker DM, Ding X. Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes p450 and cytotoxicity in the olfactory mucosa Toxicology and Applied Pharmacology. 146: 134-143. PMID 9299605 DOI: 10.1006/Taap.1997.8238 |
0.436 |
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| 1997 |
Zhang QY, Ding X, Kaminsky LS. CDNA cloning, heterologous expression, and characterization of rat intestinal CYP2J4. Archives of Biochemistry and Biophysics. 340: 270-8. PMID 9143331 DOI: 10.1006/Abbi.1997.9922 |
0.432 |
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| 1997 |
Hua Z, Zhang QY, Su T, Lipinskas TW, Ding X. cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase. Archives of Biochemistry and Biophysics. 340: 208-14. PMID 9143323 DOI: 10.1006/Abbi.1997.9899 |
0.568 |
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| 1997 |
Thornton-Manning JR, Nikula KJ, Hotchkiss JA, Avila KJ, Rohrbacher KD, Ding X, Dahl AR. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Toxicology and Applied Pharmacology. 142: 22-30. PMID 9007030 DOI: 10.1006/Taap.1996.7975 |
0.456 |
|
| 1996 |
Su T, Sheng JJ, Lipinskas TW, Ding X. Expression of CYP2A genes in rodent and human nasal mucosa. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 24: 884-90. PMID 8869824 |
0.579 |
|
| 1996 |
Liu C, Zhuo X, Gonzalez FJ, Ding X. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants. Molecular Pharmacology. 50: 781-8. PMID 8863822 |
0.652 |
|
| 1992 |
Hong JY, Ding X, Smith TJ, Coon MJ, Yang CS. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen, by rabbit nasal microsomes and cytochrome P450s NMa and NMb. Carcinogenesis. 13: 2141-4. PMID 1423886 DOI: 10.1093/Carcin/13.11.2141 |
0.344 |
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| 1991 |
Ding XX, Coon MJ. Purification and characterization of cytochromes P450 in rabbit nasal microsomes. Methods in Enzymology. 206: 603-12. PMID 1664483 DOI: 10.1016/0076-6879(91)06130-U |
0.415 |
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