Patrick W. Mantyh - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Neuroscience Biology, Pathology, Oncology

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 D'Arcy Y, Mantyh P, Yaksh T, Donevan S, Hall J, Sadrarhami M, Viktrup L. Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies. Postgraduate Medicine. 1-16. PMID 34252357 DOI: 10.1080/00325481.2021.1949199  0.307
2020 Barker PA, Mantyh P, Arendt-Nielsen L, Viktrup L, Tive L. Nerve Growth Factor Signaling and Its Contribution to Pain. Journal of Pain Research. 13: 1223-1241. PMID 32547184 DOI: 10.2147/Jpr.S247472  0.416
2019 Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve-growth-factor antibody for the treatment of osteoarthritis pain and chronic low back pain: mechanism of action in the context of efficacy and safety. Pain. PMID 31145219 DOI: 10.1097/J.Pain.0000000000001625  0.467
2018 Enomoto M, Mantyh PW, Murrell J, Innes JF, Lascelles BDX. Antinerve growth factor monoclonal antibodies for the control of pain in dogs and cats. The Veterinary Record. PMID 30368458 DOI: 10.1136/Vr.104590  0.438
2018 Mantyh PW. Mechanisms that drive bone pain across the lifespan. British Journal of Clinical Pharmacology. PMID 30357885 DOI: 10.1111/Bcp.13801  0.586
2018 Majuta LA, Mitchell SAT, Kuskowski MA, Mantyh PW. Anti-NGF Does not Change Physical Activity in Normal Young or Aging Mice but Does Increase Activity in Mice with Skeletal Pain. Pain. PMID 29994990 DOI: 10.1097/J.Pain.0000000000001330  0.46
2018 Mitchell SAT, Majuta LA, Mantyh PW. New Insights in Understanding and Treating Bone Fracture Pain. Current Osteoporosis Reports. PMID 29948820 DOI: 10.1007/S11914-018-0446-8  0.45
2018 Chartier SR, Mitchell SAT, Majuta LA, Mantyh PW. The changing sensory and sympathetic innervation of the young, adult and aging mouse femur. Neuroscience. PMID 29432884 DOI: 10.1016/J.Neuroscience.2018.01.047  0.379
2017 Majuta LA, Guedon JG, Mitchell SAT, Kuskowski MA, Mantyh PW. Mice with cancer-induced bone pain show a marked decline in day/night activity. Pain Reports. 2: e614. PMID 29392229 DOI: 10.1097/PR9.0000000000000614  0.521
2017 Majuta LA, Guedon JG, Mitchell SA, Ossipov MH, Mantyh PW. Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain. Pain. 158: 605-617. PMID 28301858 DOI: 10.1097/J.Pain.0000000000000799  0.433
2016 Majuta LA, Guedon JG, Mitchell SA, Ossipov MH, Mantyh PW. Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery induced pain. Pain. PMID 28009632 DOI: 10.1097/j.pain.0000000000000799  0.322
2016 Majuta LA, Guedon JG, Mitchell SA, Ossipov MH, Mantyh PW. Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery induced pain. Pain. PMID 27984493 DOI: 10.1097/j.pain.0000000000000799  0.322
2016 Paice JA, Mulvey M, Bennett M, Dougherty PM, Farrar JT, Mantyh PW, Miaskowski C, Schmidt B, Smith TJ. AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions. The Journal of Pain : Official Journal of the American Pain Society. PMID 27884691 DOI: 10.1016/J.Jpain.2016.10.020  0.538
2016 Thompson ML, Chartier SR, Mitchell SA, Mantyh PW. Preventing painful age-related bone fractures: Anti-sclerostin therapy builds cortical bone and increases the proliferation of osteogenic cells in the periosteum of the geriatric mouse femur. Molecular Pain. 12. PMID 27837171 DOI: 10.1177/1744806916677147  0.482
2016 Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW. The Cystine/Glutamate Antiporter System xc- Drives Breast Tumor Cell Glutamate Release and Cancer-Induced Bone Pain. Pain. PMID 27482630 DOI: 10.1097/J.Pain.0000000000000681  0.499
2016 Guedon JM, Longo G, Majuta LA, Thomspon ML, Fealk MN, Mantyh PW. Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain. Pain. 157: 1239-47. PMID 27186713 DOI: 10.1097/J.Pain.0000000000000514  0.559
2015 Thompson ML, Jimenez-Andrade JM, Mantyh PW. Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26701970 DOI: 10.1369/0022155415626499  0.333
2015 Thompson ML, Jimenez-Andrade JM, Chartier S, Tsai J, Burton EA, Habets G, Lin PS, West BL, Mantyh PW. Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer. Pain. 156: 1692-702. PMID 25993548 DOI: 10.1097/J.Pain.0000000000000228  0.57
2015 Kim JY, Tillu DV, Quinn TL, Mejia GL, Shy A, Asiedu MN, Murad E, Schumann AP, Totsch SK, Sorge RE, Mantyh PW, Dussor G, Price TJ. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6307-17. PMID 25904784 DOI: 10.1523/Jneurosci.3481-14.2015  0.446
2015 Majuta LA, Longo G, Fealk MN, McCaffrey G, Mantyh PW. Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor. Pain. 156: 157-65. PMID 25599311 DOI: 10.1016/J.Pain.0000000000000017  0.534
2015 Mantyh PW. Bone-related nociception Musculoskeletal Pain: Basic Mechanisms and Implications 0.318
2015 Jimenez-Andrade JM, Mantyh PW. Bone cancer pain: Translation of preclinical studies to human clinical trials Pain Models: Translational Relevance and Applications 0.434
2014 McCaffrey G, Thompson ML, Majuta L, Fealk MN, Chartier S, Longo G, Mantyh PW. NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use. Cancer Research. 74: 7014-23. PMID 25287160 DOI: 10.1158/0008-5472.Can-14-1220  0.547
2014 Chartier SR, Thompson ML, Longo G, Fealk MN, Majuta LA, Mantyh PW. Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain. Pain. 155: 2323-36. PMID 25196264 DOI: 10.1016/J.Pain.2014.08.026  0.507
2014 Mantyh PW. Bone cancer pain: from mechanism to therapy. Current Opinion in Supportive and Palliative Care. 8: 83-90. PMID 24792411 DOI: 10.1097/Spc.0000000000000048  0.555
2014 Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, ... Mantyh PW, et al. The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. The Journal of Pain : Official Journal of the American Pain Society. 15: 241-9. PMID 24581634 DOI: 10.1016/J.Jpain.2014.01.004  0.477
2014 Mantyh PW. The neurobiology of skeletal pain. The European Journal of Neuroscience. 39: 508-19. PMID 24494689 DOI: 10.1111/Ejn.12462  0.527
2014 Mantyh PW, Thompson ML, Chartier S, Fealk M. Bone cancer: Current opinion in palliative care Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. 579-589. DOI: 10.1016/B978-0-12-416721-6.00048-0  0.515
2013 Mantyh P. Bone cancer pain: causes, consequences, and therapeutic opportunities. Pain. S54-62. PMID 23916671 DOI: 10.1016/J.Pain.2013.07.044  0.604
2013 Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/Jbmr.1732  0.598
2012 Chapurlat RD, Gensburger D, Jimenez-Andrade JM, Ghilardi JR, Kelly M, Mantyh P. Pathophysiology and medical treatment of pain in fibrous dysplasia of bone. Orphanet Journal of Rare Diseases. S3. PMID 22640953 DOI: 10.1186/1750-1172-7-S1-S3  0.588
2012 Reilly RM, McDonald HA, Puttfarcken PS, Joshi SK, Lewis L, Pai M, Franklin PH, Segreti JA, Neelands TR, Han P, Chen J, Mantyh PW, Ghilardi JR, Turner TM, Voight EA, et al. Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature. The Journal of Pharmacology and Experimental Therapeutics. 342: 416-28. PMID 22570364 DOI: 10.1124/Jpet.111.190314  0.373
2012 Jimenez-Andrade JM, Mantyh PW. Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice. Arthritis Research & Therapy. 14: R101. PMID 22548760 DOI: 10.1186/Ar3826  0.432
2012 Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Coughlin KA, Kaczmarska MJ, Castaneda-Corral G, Bloom AP, Kuskowski MA, Mantyh PW. Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint. Arthritis and Rheumatism. 64: 2223-32. PMID 22246649 DOI: 10.1002/Art.34385  0.417
2012 Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Neurobiology of Aging. 33: 921-32. PMID 20947214 DOI: 10.1016/J.Neurobiolaging.2010.08.008  0.464
2011 Jimenez-Andrade JM, Ghilardi JR, Castañeda-Corral G, Kuskowski MA, Mantyh PW. Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. Pain. 152: 2564-74. PMID 21907491 DOI: 10.1016/J.Pain.2011.07.020  0.492
2011 Mantyh PW, Koltzenburg M, Mendell LM, Tive L, Shelton DL. Antagonism of nerve growth factor-TrkA signaling and the relief of pain. Anesthesiology. 115: 189-204. PMID 21602663 DOI: 10.1097/Aln.0B013E31821B1Ac5  0.432
2011 Bloom AP, Jimenez-Andrade JM, Taylor RN, Castañeda-Corral G, Kaczmarska MJ, Freeman KT, Coughlin KA, Ghilardi JR, Kuskowski MA, Mantyh PW. Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers. The Journal of Pain : Official Journal of the American Pain Society. 12: 698-711. PMID 21497141 DOI: 10.1016/J.Jpain.2010.12.016  0.55
2011 Castañeda-Corral G, Jimenez-Andrade JM, Bloom AP, Taylor RN, Mantyh WG, Kaczmarska MJ, Ghilardi JR, Mantyh PW. The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A. Neuroscience. 178: 196-207. PMID 21277945 DOI: 10.1016/J.Neuroscience.2011.01.039  0.494
2011 Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Bouhana KS, Trollinger D, Winkler J, Lee P, Andrews SW, Kuskowski MA, Mantyh PW. Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. Bone. 48: 389-98. PMID 20854944 DOI: 10.1016/J.Bone.2010.09.019  0.47
2011 Jimenez-Andrade JM, Bloom AP, Kaczmarska MJ, Burton EA, Zhang J, Lin PS, West BL, Mantyh PW. Abstract A246: Blockade of CSF-1R/CSF-1 signaling by PLX3397 attenuates prostate cancer cell growth in bone, prostate cancer-induced skeletal pain, and pathological bone remodeling. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A246  0.513
2011 Ondoua A, Hanlon K, Largent-Milnes T, Sukhtankar D, King T, Mantyh P, Vanderah T. CB2 receptor agonists act as a disease-modifying treatment by attenuating breast cancer-induced bone pain and improving bone health in a murine model of breast cancer metastases The Journal of Pain. 12: P51. DOI: 10.1016/J.Jpain.2011.02.207  0.492
2010 Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Kuskowski MA, Mantyh PW. Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Molecular Pain. 6: 87. PMID 21138586 DOI: 10.1186/1744-8069-6-87  0.6
2010 Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14649-56. PMID 21048122 DOI: 10.1523/Jneurosci.3300-10.2010  0.549
2010 Mantyh WG, Jimenez-Andrade JM, Stake JI, Bloom AP, Kaczmarska MJ, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW. Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience. 171: 588-98. PMID 20851743 DOI: 10.1016/J.Neuroscience.2010.08.056  0.543
2010 Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW. Bone cancer pain. Annals of the New York Academy of Sciences. 1198: 173-81. PMID 20536932 DOI: 10.1111/J.1749-6632.2009.05429.X  0.601
2010 Lozano-Ondoua AN, Wright C, Vardanyan A, King T, Largent-Milnes TM, Nelson M, Jimenez-Andrade JM, Mantyh PW, Vanderah TW. A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. Life Sciences. 86: 646-53. PMID 20176037 DOI: 10.1016/J.Lfs.2010.02.014  0.6
2010 Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW. A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone. 46: 306-13. PMID 19766746 DOI: 10.1016/J.Bone.2009.09.013  0.436
2010 Hanlon K, Lozano-Ondoua A, Chandramouli A, Largent-Milnes T, Umaretiya P, Stapleton D, Nelson M, Mantyh P, Vanderah T. Abstract P1-11-23: Cannabinoid Receptor 2 Compounds in the Attenuation of Breast Cancer Cell Proliferation: Mechanisms of Action Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P1-11-23  0.325
2010 Mantyh PW, Yaksh TL. An integrative approach to the control of cancer pain The Neurobiology of Pain: (Molecular and Cellular Neurobiology). DOI: 10.1093/acprof:oso/9780198515616.003.0015  0.367
2010 Yaksh TL, Mantyh PW. Spinal delivery of drugs in pain control The Neurobiology of Pain: (Molecular and Cellular Neurobiology). DOI: 10.1093/acprof:oso/9780198515616.003.0008  0.309
2010 Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW. Erratum to “A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain” [Bone 46 (2010) 306–313] Bone. 46: 1670-1671. DOI: 10.1016/J.Bone.2010.03.004  0.397
2010 Herrera M, Jimenez-Andrade JM, Vardanyan M, Mantyh PW. Malignant skeletal pain: Mechanisms and potential therapeutic opportunities Bone Cancer. 321-332. DOI: 10.1016/B978-0-12-374895-9.00027-X  0.517
2009 Jimenez-Andrade JM, Bloom AP, Mantyh WG, Koewler NJ, Freeman KT, Delong D, Ghilardi JR, Kuskowski MA, Mantyh PW. Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. Neuroscience. 162: 1244-54. PMID 19486928 DOI: 10.1016/J.Neuroscience.2009.05.065  0.471
2009 Bove SE, Flatters SJ, Inglis JJ, Mantyh PW. New advances in musculoskeletal pain. Brain Research Reviews. 60: 187-201. PMID 19166876 DOI: 10.1016/J.Brainresrev.2008.12.012  0.521
2009 Honore P, Chandran P, Hernandez G, Gauvin DM, Mikusa JP, Zhong C, Joshi SK, Ghilardi JR, Sevcik MA, Fryer RM, Segreti JA, Banfor PN, Marsh K, Neelands T, Bayburt E, ... ... Mantyh PW, et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain. 142: 27-35. PMID 19135797 DOI: 10.1016/J.Pain.2008.11.004  0.501
2008 Halvorson KG, Sevcik MA, Ghilardi JR, Sullivan LJ, Koewler NJ, Bauss F, Mantyh PW. Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer. Journal of Pain and Symptom Management. 36: 289-303. PMID 18411018 DOI: 10.1016/j.jpainsymman.2007.10.005  0.543
2008 Jimenez-Andrade JM, Herrera MB, Ghilardi JR, Vardanyan M, Melemedjian OK, Mantyh PW. Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Molecular Pain. 4: 10. PMID 18353190 DOI: 10.1186/1744-8069-4-10  0.301
2008 Freeman KT, Koewler NJ, Jimenez-Andrade JM, Buus RJ, Herrera MB, Martin CD, Ghilardi JR, Kuskowski MA, Mantyh PW. A fracture pain model in the rat: adaptation of a closed femur fracture model to study skeletal pain. Anesthesiology. 108: 473-83. PMID 18292685 DOI: 10.1097/Aln.0B013E3181649351  0.4
2007 Loprinzi CL, Maddocks-Christianson K, Wolf SL, Rao RD, Dyck PJ, Mantyh P, Dyck PJ. The Paclitaxel acute pain syndrome: sensitization of nociceptors as the putative mechanism. Cancer Journal (Sudbury, Mass.). 13: 399-403. PMID 18032978 DOI: 10.1097/Ppo.0B013E31815A999B  0.473
2007 Martin CD, Jimenez-Andrade JM, Ghilardi JR, Mantyh PW. Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. Neuroscience Letters. 427: 148-52. PMID 17950532 DOI: 10.1016/J.Neulet.2007.08.055  0.441
2007 Peters CM, Jimenez-Andrade JM, Kuskowski MA, Ghilardi JR, Mantyh PW. An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat. Brain Research. 1168: 46-59. PMID 17698044 DOI: 10.1016/J.Brainres.2007.06.066  0.372
2007 Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ, Halvorson KG, Barthold CM, Peters CM, Buus RJ, Ghilardi JR, Lewis JL, Kuskowski MA, Mantyh PW. Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Pain. 133: 183-96. PMID 17693023 DOI: 10.1016/J.Pain.2007.06.016  0.444
2007 Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron. 55: 377-91. PMID 17678852 DOI: 10.1016/J.Neuron.2007.07.012  0.495
2007 Koewler NJ, Freeman KT, Buus RJ, Herrera MB, Jimenez-Andrade JM, Ghilardi JR, Peters CM, Sullivan LJ, Kuskowski MA, Lewis JL, Mantyh PW. Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1732-42. PMID 17638576 DOI: 10.1359/Jbmr.070711  0.483
2007 Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW. Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Experimental Neurology. 203: 42-54. PMID 17005179 DOI: 10.1016/J.Expneurol.2006.07.022  0.359
2006 Mantyh PW. Cancer pain and its impact on diagnosis, survival and quality of life. Nature Reviews. Neuroscience. 7: 797-809. PMID 16988655 DOI: 10.1038/Nrn1914  0.469
2006 Sevcik MA, Jonas BM, Lindsay TH, Halvorson KG, Ghilardi JR, Kuskowski MA, Mukherjee P, Maggio JE, Mantyh PW. Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer. Gastroenterology. 131: 900-10. PMID 16952558 DOI: 10.1053/J.Gastro.2006.06.021  0.494
2006 Halvorson KG, Sevcik MA, Ghilardi JR, Rosol TJ, Mantyh PW. Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer. The Clinical Journal of Pain. 22: 587-600. PMID 16926574 DOI: 10.1097/01.Ajp.0000210902.67849.E6  0.604
2006 Jimenez-Andrade JM, Peters CM, Mejia NA, Ghilardi JR, Kuskowski MA, Mantyh PW. Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat. Neuroscience Letters. 405: 62-7. PMID 16854522 DOI: 10.1016/J.Neulet.2006.06.043  0.348
2006 Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 91: 286-98. PMID 16500924 DOI: 10.1093/Toxsci/Kfj143  0.358
2006 Lindsay TH, Halvorson KG, Peters CM, Ghilardi JR, Kuskowski MA, Wong GY, Mantyh PW. A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas. Neuroscience. 137: 1417-26. PMID 16388907 DOI: 10.1016/J.Neuroscience.2005.10.055  0.37
2006 Halvorson K, Ghilardi J, Mantyh P. 53 MECHANISMS OF OSTEOARTHRITIC AND SKELETAL PAIN European Journal of Pain. 10: S15-S15. DOI: 10.1016/S1090-3801(06)60056-6  0.494
2006 Mantyh P. The science behind metastatic bone pain European Journal of Cancer Supplements. 4: 4-8. DOI: 10.1016/J.Ejcsup.2006.07.003  0.615
2006 Mantyh P. Mechanisms of bone cancer pain relief with bisphosphonates Bone. 38: 56. DOI: 10.1016/J.Bone.2005.12.058  0.601
2006 Mantyh PW. Pain Due to Bone Metastases: New Research Issues and Their Clinical Implications Cancer Pain. 75-84. DOI: 10.1016/B978-0-7216-0261-5.50012-0  0.418
2005 Lindsay TH, Jonas BM, Sevcik MA, Kubota K, Halvorson KG, Ghilardi JR, Kuskowski MA, Stelow EB, Mukherjee P, Gendler SJ, Wong GY, Mantyh PW. Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression. Pain. 119: 233-46. PMID 16298491 DOI: 10.1016/J.Pain.2005.10.019  0.499
2005 Sevcik MA, Ghilardi JR, Halvorson KG, Lindsay TH, Kubota K, Mantyh PW. Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model. The Journal of Pain : Official Journal of the American Pain Society. 6: 771-5. PMID 16275602 DOI: 10.1016/J.Jpain.2005.06.010  0.61
2005 Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE, Ghilardi JR, Rosol TJ, Boustany L, Shelton DL, Mantyh PW. A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Research. 65: 9426-35. PMID 16230406 DOI: 10.1158/0008-5472.Can-05-0826  0.576
2005 Goblirsch M, Lynch C, Mathews W, Manivel JC, Mantyh PW, Clohisy DR. Radiation treatment decreases bone cancer pain through direct effect on tumor cells. Radiation Research. 164: 400-8. PMID 16187742 DOI: 10.1667/Rr3439.1  0.577
2005 Luger NM, Mach DB, Sevcik MA, Mantyh PW. Bone cancer pain: from model to mechanism to therapy. Journal of Pain and Symptom Management. 29: S32-46. PMID 15907645 DOI: 10.1016/J.Jpainsymman.2005.01.008  0.85
2005 Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG, Jonas BM, Kubota K, Kuskowski MA, Boustany L, Shelton DL, Mantyh PW. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain. 115: 128-41. PMID 15836976 DOI: 10.1016/J.Pain.2005.02.022  0.57
2005 Peters CM, Ghilardi JR, Keyser CP, Kubota K, Lindsay TH, Luger NM, Mach DB, Schwei MJ, Sevcik MA, Mantyh PW. Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain. Experimental Neurology. 193: 85-100. PMID 15817267 DOI: 10.1016/J.Expneurol.2004.11.028  0.847
2005 Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, ... Mantyh PW, et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3126-31. PMID 15788769 DOI: 10.1523/Jneurosci.3815-04.2005  0.623
2005 Sabino MA, Mantyh PW. Pathophysiology of bone cancer pain. The Journal of Supportive Oncology. 3: 15-24. PMID 15724942  0.839
2005 Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA. Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. Journal of Neurophysiology. 93: 998-1006. PMID 15456795 DOI: 10.1152/Jn.01160.2003  0.327
2004 Clohisy DR, Mantyh PW. Bone cancer pain and the role of RANKL/OPG Journal of Musculoskeletal Neuronal Interactions. 4: 293-300. PMID 15615497  0.517
2004 Mantyh PW. A mechanism-based understanding of bone cancer pain. Novartis Foundation Symposium. 261: 194-214; discussion . PMID 15469052  0.556
2004 Mantyh PW, Hunt SP. Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity. Trends in Neurosciences. 27: 582-4. PMID 15374667 DOI: 10.1016/J.Tins.2004.07.007  0.406
2004 Sevcik MA, Luger NM, Mach DB, Sabino MA, Peters CM, Ghilardi JR, Schwei MJ, Röhrich H, De Felipe C, Kuskowski MA, Mantyh PW. Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis. Pain. 111: 169-80. PMID 15327821 DOI: 10.1016/J.Pain.2004.06.015  0.827
2004 Mantyh PW, Hunt SP. Mechanisms that generate and maintain bone cancer pain. Novartis Foundation Symposium. 260: 221-38; discussion 2. PMID 15283453 DOI: 10.1002/0470867639.Ch15  0.62
2004 Peters CM, Lindsay TH, Pomonis JD, Luger NM, Ghilardi JR, Sevcik MA, Mantyh PW. Endothelin and the tumorigenic component of bone cancer pain. Neuroscience. 126: 1043-52. PMID 15207337 DOI: 10.1016/J.Neuroscience.2004.04.027  0.595
2004 Yezierski RP, Yu CG, Mantyh PW, Vierck CJ, Lappi DA. Spinal neurons involved in the generation of at-level pain following spinal injury in the rat. Neuroscience Letters. 361: 232-6. PMID 15135936 DOI: 10.1016/J.Neulet.2003.12.035  0.423
2004 Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2727-32. PMID 15028765 DOI: 10.1523/Jneurosci.5054-03.2004  0.327
2004 Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR. Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size Radiation Research. 161: 228-234. PMID 14731066 DOI: 10.1667/Rr3108  0.578
2004 Sabino M, Luger N, Keyser C, Schwei M, Mach D, Sevcik M, Peters C, Mantyh P. Tumor-induced injury of sensory nerve fibers in bone cancer pain Journal of Oral and Maxillofacial Surgery. 62: 21-22. DOI: 10.1016/J.Joms.2004.05.143  0.758
2004 Sabino MAC, Mantyh PW. Clinically related behavioral models: Bone cancer pain Drug Discovery Today: Disease Models. 1: 127-134. DOI: 10.1016/J.Ddmod.2004.09.007  0.611
2003 Clohisy DR, Mantyh PW. Bone cancer pain. Clinical Orthopaedics and Related Research. S279-88. PMID 14600620 DOI: 10.1097/01.Blo.0000093059.96273.56  0.59
2003 Sabino MA, Luger NM, Mach DB, Rogers SD, Schwei MJ, Mantyh PW. Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system. International Journal of Cancer. Journal International Du Cancer. 104: 550-8. PMID 12594809 DOI: 10.1002/Ijc.10999  0.834
2003 Clohisy DR, Mantyh PW. Bone cancer pain. Cancer. 97: 866-73. PMID 12548588 DOI: 10.1002/Cncr.11144  0.59
2003 Sabino MAC, Sevcik M, Luger N, Mantyh P. The bisphosphonate alendronate modulates pain, tumor growth, and skeletal remodeling in a bone cancer model Journal of Oral and Maxillofacial Surgery. 61: 36-37. DOI: 10.1016/S0278-2391(03)00526-3  0.571
2002 Sabino MC, Ghilardi JR, Feia KJ, Jongen JL, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, De Filipe C, Mantyh PW. The involvement of prostaglandins in tumorigenesis, tumor-induced osteolysis and bone cancer pain. Journal of Musculoskeletal & Neuronal Interactions. 2: 561-2. PMID 15758394  0.841
2002 Honoré P, Kamp EH, Rogers SD, Gebhart GF, Mantyh PW. Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 3: 3-11. PMID 14622848 DOI: 10.1054/Jpai.2002.27001  0.358
2002 Sabino MA, Ghilardi JR, Jongen JL, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, de Felipe C, Mantyh PW. Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. Cancer Research. 62: 7343-9. PMID 12499278  0.836
2002 Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 99: 397-406. PMID 12406514 DOI: 10.1016/S0304-3959(02)00102-1  0.831
2002 Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA. Spinal neurons that possess the substance P receptor are required for the development of central sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9086-98. PMID 12388616 DOI: 10.1523/Jneurosci.22-20-09086.2002  0.368
2002 Mach DB, Rogers SD, Sabino MC, Luger NM, Schwei MJ, Pomonis JD, Keyser CP, Clohisy DR, Adams DJ, O'Leary P, Mantyh PW. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience. 113: 155-66. PMID 12123694 DOI: 10.1016/S0306-4522(02)00165-3  0.823
2002 Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP. Molecular mechanisms of cancer pain. Nature Reviews. Cancer. 2: 201-9. PMID 11990856 DOI: 10.1038/Nrc747  0.519
2002 Mantyh PW. A mechanism based understanding of cancer pain. Pain. 96: 1-2. PMID 11932054 DOI: 10.1016/S0304-3959(01)00482-1  0.516
2002 Sabino MA, Honore P, Rogers SD, Mach DB, Luger NM, Mantyh PW. Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain. Pain. 95: 175-86. PMID 11790480 DOI: 10.1016/S0304-3959(01)00397-9  0.771
2002 Sabino MAC, Mantyh PW. Is tooth extraction a good model for dental pain? a critic to Sabino et al. (Pain 2002;95:175–86) Pain. 99: 606-608. DOI: 10.1016/S0304-3959(02)00309-3  0.433
2001 Mantyh PW, Yaksh TL. Sensory neurons are PARtial to pain. Nature Medicine. 7: 772-3. PMID 11433334 DOI: 10.1038/89880  0.412
2001 Luger NM, Honore P, Sabino MA, Schwei MJ, Rogers SD, Mach DB, Clohisy DR, Mantyh PW. Osteoprotegerin diminishes advanced bone cancer pain. Cancer Research. 61: 4038-47. PMID 11358823  0.837
2001 Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nature Reviews. Neuroscience. 2: 83-91. PMID 11252998 DOI: 10.1038/35053509  0.495
2001 Pomonis JD, Rogers SD, Peters CM, Ghilardi JR, Mantyh PW. Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 999-1006. PMID 11157085 DOI: 10.1523/Jneurosci.21-03-00999.2001  0.307
2000 Honoré P, Schwei J, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW. Cellular and neurochemical remodeling of the spinal cord in bone cancer pain. Progress in Brain Research. 129: 389-97. PMID 11098706 DOI: 10.1016/S0079-6123(00)29030-4  0.62
2000 Honoré P, Menning PM, Rogers SD, Nichols ML, Mantyh PW. Neurochemical plasticity in persistent inflammatory pain. Progress in Brain Research. 129: 357-63. PMID 11098703 DOI: 10.1016/S0079-6123(00)29027-4  0.48
2000 Honore P, Rogers SD, Schwei MJ, Salak-Johnson JL, Luger NM, Sabino MC, Clohisy DR, Mantyh PW. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience. 98: 585-98. PMID 10869852 DOI: 10.1016/S0306-4522(00)00110-X  0.523
2000 Honore P, Luger NM, Sabino MA, Schwei MJ, Rogers SD, Mach DB, O'keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nature Medicine. 6: 521-8. PMID 10802707 DOI: 10.1038/74999  0.838
2000 Honore P, Mantyh PW. Bone Cancer Pain: From Mechanism to Model to Therapy Pain Medicine. 1: 303-309. DOI: 10.1046/J.1526-4637.2000.00047.X  0.636
1999 Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10886-97. PMID 10594070 DOI: 10.1523/Jneurosci.19-24-10886.1999  0.609
1999 Nichols ML, Allen BJ, Rogers SD, Ghilardi JR, Honore P, Luger NM, Finke MP, Li J, Lappi DA, Simone DA, Mantyh PW. Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science (New York, N.Y.). 286: 1558-61. PMID 10567262 DOI: 10.1126/Science.286.5444.1558  0.484
1999 Trafton JA, Abbadie C, Marchand S, Mantyh PW, Basbaum AI. Spinal opioid analgesia: how critical is the regulation of substance P signaling? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9642-53. PMID 10531466 DOI: 10.1523/Jneurosci.19-21-09642.1999  0.302
1999 Honor P, Menning PM, Rogers SD, Nichols ML, Basbaum AI, Besson JM, Mantyh PW. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7670-8. PMID 10460273 DOI: 10.1523/Jneurosci.19-17-07670.1999  0.46
1999 Allen BJ, Li J, Menning PM, Rogers SD, Ghilardi J, Mantyh PW, Simone DA. Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury. Journal of Neurophysiology. 81: 1379-90. PMID 10085363 DOI: 10.1152/Jn.1999.81.3.1379  0.312
1998 Mantyh PW, Hunt SP. Hot peppers and pain. Neuron. 21: 644-5. PMID 9808445 DOI: 10.1016/S0896-6273(00)80575-9  0.492
1998 Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI. Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 392: 390-4. PMID 9537322 DOI: 10.1038/32897  0.498
1997 Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, Li J, Daughters RS, Lappi DA, Wiley RG, Simone DA. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (New York, N.Y.). 278: 275-9. PMID 9323204 DOI: 10.1126/Science.278.5336.275  0.352
1997 Abbadie C, Trafton J, Liu H, Mantyh PW, Basbaum AI. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8049-60. PMID 9315923 DOI: 10.1523/Jneurosci.17-20-08049.1997  0.323
1997 Allen BJ, Rogers SD, Ghilardi JR, Menning PM, Kuskowski MA, Basbaum AI, Simone DA, Mantyh PW. Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5921-7. PMID 9221788 DOI: 10.1523/Jneurosci.17-15-05921.1997  0.317
1997 Liu H, Mantyh PW, Basbaum AI. NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature. 386: 721-4. PMID 9109489 DOI: 10.1038/386721A0  0.446
1996 Abbadie C, Brown JL, Mantyh PW, Basbaum AI. Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience. 70: 201-9. PMID 8848125 DOI: 10.1016/0306-4522(95)00343-H  0.419
1995 Brown JL, Liu H, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI. Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis. The Journal of Comparative Neurology. 356: 327-44. PMID 7642798 DOI: 10.1002/Cne.903560302  0.323
1995 Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science (New York, N.Y.). 268: 1629-32. PMID 7539937 DOI: 10.1126/Science.7539937  0.319
1994 Mantyh PW, Allen CJ, Rogers S, DeMaster E, Ghilardi JR, Mosconi T, Kruger L, Mannon PJ, Taylor IL, Vigna SR. Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3958-68. PMID 8207499 DOI: 10.1523/Jneurosci.14-06-03958.1994  0.343
1994 Ghilardi JR, Allen CJ, Vigna SR, McVey DC, Mantyh PW. Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons. Brain Research. 633: 33-40. PMID 8137166 DOI: 10.1016/0006-8993(94)91519-9  0.305
1992 Ghilardi JR, Allen CJ, Vigna SR, McVey DC, Mantyh PW. Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate-CCK analgesic interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4854-66. PMID 1334505 DOI: 10.1523/Jneurosci.12-12-04854.1992  0.329
1992 Mantyh PW, Catton MD, Allen CJ, Labenski ME, Maggio JE, Vigna SR. Receptor binding sites for cholecystokinin, galanin, somatostatin, substance P and vasoactive intestinal polypeptide in sympathetic ganglia. Neuroscience. 46: 739-54. PMID 1312231 DOI: 10.1016/0306-4522(92)90160-4  0.307
1989 Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP, Maggio JE, Vigna SR. Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides. 10: 627-45. PMID 2550912 DOI: 10.1016/0196-9781(89)90154-X  0.304
1987 Mantyh PW, Abols IA, Mehler WR. A Compendium on Pain Contemporary Psychology: a Journal of Reviews. 32: 880-881. DOI: 10.1037/026434  0.395
1985 Mantyh PW, Hunt SP. The autoradiographic localization of substance P receptors in the rat and bovine spinal cord and the rat and cat spinal trigeminal nucleus pars caudalis and the effects of neonatal capsaicin. Brain Research. 332: 315-24. PMID 2986763 DOI: 10.1016/0006-8993(85)90600-6  0.307
1983 Mantyh PW. The ascending input to the midbrain periaqueductal gray of the primate. The Journal of Comparative Neurology. 211: 50-64. PMID 7174883 DOI: 10.1002/Cne.902110106  0.308
1983 Mantyh PW, Peschanski M. Spinal projections from the periaqueductal grey and dorsal raphe in the rat, cat and monkey. Neuroscience. 7: 2769-76. PMID 7155351 DOI: 10.1016/0306-4522(82)90099-9  0.31
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